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Environmental Factors In Neurodevelopmental And Neurodegenerative Disorders

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Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders

Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders Book
Author : Michael Aschner,Lucio G. Costa
Publisher : Academic Press
Release : 2015-06-18
ISBN : 012800407X
Language : En, Es, Fr & De

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Book Description :

Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders presents a state-of-the-art review of the effects of environmental contaminants on the development and degeneration of the human nervous system, brought together by world-leading experts in the field. Part One describes the adverse effects that the environment can have on neurological development, and how these effects may exhibit. Specific contaminants and their possible consequences of exposure are addressed (lead, methylmercury, alcohol), as well as specific disorders and the environmental factors associated with them, such as the effect of diet on attention deficit and hyperactivity disorders. Part Two tackles neurodegenerative disorders, specifically addressing their potential neurotoxic origins, and discussing the increasing interest in the effects that early exposure may have in later life. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders is an invaluable reference for those professionals working in the fields of toxicology, environmental health and neuroscience. Provides, for the first time, the cutting-edge theory of environmental impacts on both neurodegenerative and neurodevelopmental disorders Written by an international selection of the world’s foremost experts in the field of neurotoxicology Full-colour throughout, providing accurate and illustrative examples of neurotoxic effects in action An invaluable reference for those professionals working in the fields of toxicology, environmental health, and neuroscience

Environmental Neuroscience

Environmental Neuroscience Book
Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Health and Medicine Division,Board on Environmental Studies and Toxicology,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Release : 2021-01-22
ISBN : 0309683092
Language : En, Es, Fr & De

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Book Description :

Humans are potentially exposed to more than 80,000 toxic chemicals in the environment, yet their impacts on brain health and disease are not well understood. The sheer number of these chemicals has overwhelmed the ability to determine their individual toxicity, much less potential interactive effects. Early life exposures to chemicals can have permanent consequences for neurodevelopment and for neurodegeneration in later life. Toxic effects resulting from chemical exposure can interact with other risk factors such as prenatal stress, and persistence of some chemicals in the brain over time may result in cumulative toxicity. Because neurodevelopmental and neurodegenerative disorders - such as attention-deficit hyperactivity disorder and Parkinson's disease - cannot be fully explained by genetic risk factors alone, understanding the role of individual environmental chemical exposures is critical. On June 25, 2020, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders hosted a workshop to lay the foundation for future advances in environmental neuroscience. The workshop was designed to explore new opportunities to bridge the gap between what is known about the genetic contribution to brain disorders and what is known, and not known, about the contribution of environmental influences, as well as to discuss what is known about how genetic and environmental factors interact. This publication summarizes the presentation and discussion of the workshop.

Environmental Neuroscience

Environmental Neuroscience Book
Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Health and Medicine Division,Board on Environmental Studies and Toxicology,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Release : 2020-12-22
ISBN : 0309683122
Language : En, Es, Fr & De

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Book Description :

Humans are potentially exposed to more than 80,000 toxic chemicals in the environment, yet their impacts on brain health and disease are not well understood. The sheer number of these chemicals has overwhelmed the ability to determine their individual toxicity, much less potential interactive effects. Early life exposures to chemicals can have permanent consequences for neurodevelopment and for neurodegeneration in later life. Toxic effects resulting from chemical exposure can interact with other risk factors such as prenatal stress, and persistence of some chemicals in the brain over time may result in cumulative toxicity. Because neurodevelopmental and neurodegenerative disorders - such as attention-deficit hyperactivity disorder and Parkinson's disease - cannot be fully explained by genetic risk factors alone, understanding the role of individual environmental chemical exposures is critical. On June 25, 2020, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders hosted a workshop to lay the foundation for future advances in environmental neuroscience. The workshop was designed to explore new opportunities to bridge the gap between what is known about the genetic contribution to brain disorders and what is known, and not known, about the contribution of environmental influences, as well as to discuss what is known about how genetic and environmental factors interact. This publication summarizes the presentation and discussion of the workshop.

Obesogenic Environmental Conditions Affect Neurodevelopment and Neurodegeneration

Obesogenic Environmental Conditions Affect Neurodevelopment and Neurodegeneration Book
Author : Gustavo Pacheco-Lopez,Marcel Pérez-Morales,Kioko Rubi Guzman-Ramos,Johnny Davis Figueroa,Ute Krügel,Javier A. Bravo
Publisher : Frontiers Media SA
Release : 2021-09-23
ISBN : 2889713482
Language : En, Es, Fr & De

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Book Description :

Download Obesogenic Environmental Conditions Affect Neurodevelopment and Neurodegeneration book written by Gustavo Pacheco-Lopez,Marcel Pérez-Morales,Kioko Rubi Guzman-Ramos,Johnny Davis Figueroa,Ute Krügel,Javier A. Bravo, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Linking Environmental Exposure to Neurodevelopmental Disorders

Linking Environmental Exposure to Neurodevelopmental Disorders Book
Author : Anonim
Publisher : Academic Press
Release : 2018-05-24
ISBN : 0128155523
Language : En, Es, Fr & De

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Book Description :

Advances in Neurotoxicology, Volume Two, addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson’s disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike. Includes, in one single publication, a selection of comprehensive reviews devoted to neurotoxicology Edited by high-profile, leading academics in the field, ensuring a quality publication for subscribers Aims to widen the scope for participation by international contributors, researchers and editorial board members outside North America Serves a broad audience of university faculty, researchers and students, as well as the industry, drug development companies and the government

Environmental Factors in Neurodegenerative Diseases

Environmental Factors in Neurodegenerative Diseases Book
Author : Anonim
Publisher : Academic Press
Release : 2017-09-19
ISBN : 0128127651
Language : En, Es, Fr & De

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Book Description :

Environmental Factors in Neurodegenerative Diseases, Volume One addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson’s disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike. Includes, in one single publication, a selection of comprehensive reviews devoted to neurotoxicology Edited by high-profile, leading academics in the field, ensuring a quality publication for subscribers Aims to widen the scope for participation by international contributors, researchers and editorial board members outside North America Serves a broad audience of university faculty, researchers and students, as well as the industry, drug development companies and the government

Environmental Factors and Their Role in Developmental Disorders

Environmental Factors and Their Role in Developmental Disorders Book
Author : Claire Marie Koenig
Publisher : Unknown
Release : 2012
ISBN : 9781267657633
Language : En, Es, Fr & De

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Book Description :

From conception to death exposure to environmental agents with potential toxicity is unavoidable. Advancement of the chemical industry in the 20th century has led to an estimated 70,000 to 100,000 chemicals registered for commercial use, the majority of which have had little to no toxicological testing. Further 90% of approved pharmacological drug treatments in the U.S. have no evaluation of teratogenicity or neurodevelopmental toxicity in humans. This gap in our knowledge of exposure to these chemicals and their toxicological potential is significant reason for concern. In the present study, two potential neurodevelopmental toxicants, brominated diphenyl ether-47 (BDE-47), an environmental pollutant, and misoprostol, a pharmacological agent, were evaluated for effects on brain development and behavior in mice after early developmental exposure. BDE-47 is one of 209 congeners in a class of widely used flame retardant chemicals known as polybrominated diphenyl ethers (PBDEs). BDE-47 makes up almost 50% of the congener profile in human tissues including breast milk, placenta and umbilical cord serum. To evaluate the neurotoxic potential of BDE-47, mice were chronically exposed low levels of BDE-47 (i.e., 0.03, 0.1 or 1.0 mg/kg/day) that were selected to be within the range of reported human exposure. Our research found that exposure of pregnant C567BL/6 dams to BDE-47 resulted in significant accumulation of the chemical in offspring tissue both during gestation and lactation, and levels in dam tissues were similar to those reported for humans. Behavioral testing showed that spatial learning and memory were altered in mouse pups following perinatal exposure. These results highlight the potential health risk that presented by perinatal exposure to BDE-47 and potentially other similar flame retardants. Misoprostol is commonly used in gynecological and obstetric practices at the time of birth to induce labor. However, high doses of misoprostol given early in pregnancy to induce abortion can result in Möbius Syndrome in surviving offspring as well as behaviors that show similarities with autism spectrum disorders. This raised the possibility that misoprostol treatment might show neurodevelopmental toxicity when given at the time of birth. Therefore mouse pups were exposed to one of three doses of misoprostol (0.4, 4or 40 mg/kg) at the approximate time in development equivalent to human birth. The results showed that when misoprostol is given at this developmental age it did not appear to significantly affect neurological development in mice. This failure to find evidence of neurodevelopmental toxicity from neonatal exposure to misoprostol is important because it can help future research to focus on those environmental agents that may be more likely to be involved in the etiology of neurodevelopmental disorders such as autism.

Role of Inflammation in Environmental Neurotoxicity

Role of Inflammation in Environmental Neurotoxicity Book
Author : Anonim
Publisher : Academic Press
Release : 2019-02-01
ISBN : 0128157186
Language : En, Es, Fr & De

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Book Description :

Role of Inflammation in Environmental Neurotoxicity, Volume Three, in this comprehensive serial, addresses contemporary advances in neurotoxicology by providing authoritative review articles on key issues in the field. Edited by leading subject experts, topics of note in this new release include Neuroinflammation (Introduction), Organophosphates, Lead, Manganese, Drugs of abuse, Peripheral vs central inflammation, Air pollution, Developmental neurotoxicity, Ethanol, and the Blood brain barrier, amongst other topics. Provides a unique, first of its kind resource Contributed to by world leaders in neurotoxicology Contains a diversity of topics (from molecular to epidemiology) in neurotoxicology

The SAGE Encyclopedia of Intellectual and Developmental Disorders

The SAGE Encyclopedia of Intellectual and Developmental Disorders Book
Author : Ellen Braaten
Publisher : SAGE Publications
Release : 2018-01-29
ISBN : 1506353304
Language : En, Es, Fr & De

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Book Description :

According to the CDC "about one in six, or about 15%, of children aged 3 through 17 years have one or more developmental disabilities," such as ADHD, autism spectrum disorders, cerebral palsy, intellectual disability, and learning disability. Intellectual disorders are characterized by significant limitations in both intellectual functioning and in adaptive behavior, which covers many everyday social and practical skills, impacting learning, reasoning, problem solving, and other cognitive processes. These disabilities originate before the age of 18 and continue across the life span. Developmental disorders are chronic disabilities that can be cognitive or physical or both. The disabilities appear before the age of 22 and are likely to progress across the lifespan. Some developmental disorders are largely physical issues, such as cerebral palsy or epilepsy. Some individuals may have a disorder that includes a physical and intellectual disability; for example, Down syndrome or fetal alcohol syndrome. Intellectual and developmental disorders are significant and growing issues that are studied across a number of disciplines. The SAGE Encyclopedia of Intellectual and Developmental Disorders is aimed at students interested in psychology, counseling, education, social work, psychiatry, health sciences, and more. This encyclopedia will provide an in-depth look at a wide range of disorders, alongside interventions, the latest research translated for an undergraduate audience, historical context, and assessment tools for higher-level students. We will take a truly interdisciplinary approach by also covering sociocultural viewpoints, policy implications, educational applications, ethical issues, and more.

Pathophysiology E Book

Pathophysiology   E Book Book
Author : Kathryn L. McCance,Sue E. Huether
Publisher : Elsevier Health Sciences
Release : 2018-01-10
ISBN : 032341320X
Language : En, Es, Fr & De

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Book Description :

Learn the what, how, and why of pathophysiology! With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, Pathophysiology: The Biologic Basis for Disease in Adults and Children, 8th Edition helps you understand the most important and most complex pathophysiology concepts. This updated text includes more than 1,300 full-color illustrations and photographs to make it easier to identify normal anatomy and physiology, as well as alterations of function. This edition includes a NEW chapter on obesity and nutritional disorders, along with expanded coverage of rare diseases and epigenetics. It’s the most comprehensive and authoritative pathophysiology text available! The most comprehensive and authoritative pathophysiology text on the market provides unparalleled coverage of Pathophysiology content. Over 1,300 full-color illustrations and photographs depict the clinical manifestations of disease and disease processes — more than in any other pathophysiology text. Consistent presentation of diseases includes pathophysiology, clinical manifestations, and evaluation and treatment. Lifespan content includes ten separate pediatric chapters and special sections with aging and pediatrics content. Outstanding authors Kathryn McCance and Sue Huether have extensive backgrounds as researchers and instructors, and utilize expert contributors, consultants, and reviewers in developing this edition. Algorithms and flowcharts of diseases and disorders make it easy for you to follow the sequential progression of disease processes. Additional What’s New boxes highlight the most current research and clinical development. Nutrition and Disease boxes explain the link between concepts of health promotion and disease. Chapter summary reviews provide concise synopses of the main points of each chapter. NEW! Chapter on obesity and nutritional disorders thoroughly covers these growing global concerns. NEW! Added coverage of rare diseases and epigenetics further explore genetic disease traits. NEW! Over 50 new or heavily revised illustrations visually highlight pathophysiology concepts. NEW! More than 30 new 3D animations on Evolve bring difficult concepts to life for a new perspective on disease processes.

Clinical Handbook of Air Pollution Related Diseases

Clinical Handbook of Air Pollution Related Diseases Book
Author : Fabio Capello,Antonio Vittorino Gaddi
Publisher : Springer
Release : 2018-02-21
ISBN : 3319627317
Language : En, Es, Fr & De

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Book Description :

This book examines in detail the clinical implications of those diseases that either are primarily triggered by air pollution or represent direct consequences of air pollutants. The aim is to provide medical practitioners with practical solutions to issues in diagnosis and treatment while simultaneously furnishing other interested parties with crucial information on the field. The book introduces the concept that air pollution-related diseases constitute a new class of pathologies. A wide range of conditions mainly attributable to air pollution are discussed, covering different body systems and pollution impacts in subsets of the population. In addition to presenting state of the art overviews of clinical aspects, the book carefully examines the implications of current knowledge for social and public health strategies aimed at disease prevention and prophylaxis. The Clinical Handbook of Air Pollution-Related Diseases will greatly assist doctors and healthcare workers when dealing with the consequences of air pollution in their everyday practice and will provide researchers, industry, and policymakers with valuable facts and insights.

Environmental Epigenomics in Health and Disease

Environmental Epigenomics in Health and Disease Book
Author : Randy L Jirtle,Frederick L. Tyson
Publisher : Springer Science & Business Media
Release : 2013-05-16
ISBN : 3642233805
Language : En, Es, Fr & De

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Book Description :

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.

Green Sustainable Process for Chemical and Environmental Engineering and Science

Green Sustainable Process for Chemical and Environmental Engineering and Science Book
Author : Dr. Inamuddin,Rajender Boddula,Abdullah M. Asiri
Publisher : Elsevier
Release : 2020-12-01
ISBN : 0128218983
Language : En, Es, Fr & De

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Book Description :

Green Solvents for Environmental Remediation provides an in-depth overview of environmental remediation by using eutectic solvents, ionic liquids, biosolvents, and switchable solvents, of ionic-liquids, biosolvents, Gas-expanded solvents Liquid polymers, supercritical fluids, Polymer-based green solvents, Switchable solvents, etc. This book offers all-types of green solvents for the removal of contaminations from the soil, air, and water. It summarizes in-depth literature on the application of various green solvents in the areas such as municipal water, extraction, bioremediation, phytoremediation, soil and sediment remediation, toxic gases removal, and various industrial effluents. A brief introduction, limitations, and advantages to the practical use of green solvents are also discussed. This book is authored by experts in a broad range of fields. It is an invaluable reference guide for the sustainable and environmentally friendly development of synthetic methodologies for environmental, analytical, engineering, and industrial technology. Provides an up-to-date research record on green solvents for environmental protection Includes latest advances in environmental remediation Outlines eco-friendly green solvents for toxic contaminants degradation and purification Covers all-types of green solvent-driven environmental remediation technologies Key references to obtain great results in environmental remediation using green solvents

Child Neuropsychology

Child Neuropsychology Book
Author : Margaret Semrud-Clikeman,Phyllis Anne Teeter Ellison
Publisher : Springer Science & Business Media
Release : 2009-06-15
ISBN : 9780387889634
Language : En, Es, Fr & De

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Book Description :

During the past decade, significant advances have been made in the field of neurodevelopmental disorders, resulting in a considerable impact on conceptualization, diagnostics, and practice. The second edition of Child Neuropsychology: Assessment and Interventions for Neurodevelopmental Disorders brings readers up to speed clearly and authoritatively, offering the latest information on neuroimaging technologies, individual disorders, and effective treatment of children and adolescents. Starting with the basics of clinical child neuropsychology and functional anatomy, the authors present a transactional framework for assessment, diagnosis, and intervention. The book carefully links structure and function—and behavioral and biological science—for a more nuanced understanding of brain development and of pathologies as varied as pervasive developmental disorders, learning disabilities, neuromotor dysfunction, seizure disorders, and childhood cancers. This volume features a range of salient features valuable to students as well as novice and seasoned practitioners alike, including: Overview chapters that discuss the effects of biogenic and environmental factors on neurological functioning. New emphasis on multicultural/cross-cultural aspects of neuropsychology and assessment. Brand new chapters on interpretation, neuropsychological assessment process, and report writing. An integrative model of neurological, neuroradiological, and psychological assessment and diagnosis. Balanced coverage of behavioral, pharmacological, and educational approaches to treatment. Case studies illustrating typical and distinctive presentations and successful diagnosis, treatment planning, and intervention. Important practice updates, including the new HIPAA regulations. Child Neuropsychology, 2nd Edition, is vital reading for school, clinical child, and counseling psychologists as well as neuropsychologists. The book also provides rich background and practical material for graduate students entering these fields.

Neurodegenerative Diseases

Neurodegenerative Diseases Book
Author : Daniela Galimberti,Elio Scarpini
Publisher : Springer Science & Business
Release : 2014-04-23
ISBN : 144716380X
Language : En, Es, Fr & De

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Book Description :

This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases. Different aspects of each disease are reviewed, including clinical issues, treatments, basic discoveries (genetics and molecular biology), and translation of basic research into biomarkers for early diagnosis. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.

The Two Way Link between Eating Behavior and Brain Metabolism

The Two Way Link between Eating Behavior and Brain Metabolism Book
Author : Tanya Zilberter
Publisher : Frontiers Media SA
Release : 2016-01-13
ISBN : 2889197050
Language : En, Es, Fr & De

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Book Description :

This research topic collected and connected information concerning both the underlying metabolic mechanisms and consequences of eating behaviors. These two aspects are tremendously important for a better understanding of eating behavior abnormalities as well as for improving education on eating disorders and behaviors.

Neurodegenerative Diseases

Neurodegenerative Diseases Book
Author : Shamim I. Ahmad
Publisher : Springer Science & Business Media
Release : 2012-03-12
ISBN : 1461406536
Language : En, Es, Fr & De

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Book Description :

The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.

Neurotoxicity of Metals

Neurotoxicity of Metals Book
Author : Michael Aschner,Lucio G. Costa
Publisher : Springer
Release : 2017-09-09
ISBN : 331960189X
Language : En, Es, Fr & De

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Book Description :

Assembles international authorities to address contemporary research in metal neurotoxicity. Essential and non-essential metals play an important role in neurodevelopmental and neurodegenerative diseases. Recent developments in understanding the role of metals in the etiology of these disorders have led to rapid growth in clarifying the pathology of some of the most devastating diseases we face and in identifying potential new therapies. Few books or periodicals have been wholly dedicated to the topic of metals, and this collection is intended to serve as a resource for all researchers interested in metals and their role in health and disease.

Brain Insulin Resistance in Neurodevelopmental and Neurodegenerative Disorders Mind the Gap

Brain Insulin Resistance in Neurodevelopmental and Neurodegenerative Disorders  Mind the Gap  Book
Author : Eugenio Barone,Mara Dierssen
Publisher : Frontiers Media SA
Release : 2021-10-04
ISBN : 2889634574
Language : En, Es, Fr & De

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Book Description :

The failure of insulin signaling – a condition known as insulin resistance – is a key pathological feature of both type 2 diabetes (T2DM, systemic insulin resistance) and Alzheimer’s disease and related dementias (ADRDs, brain insulin resistance) and greatly contribute to their development. Considerable overlap has been identified in the risk factors, comorbidities and putative pathophysiological mechanisms of ADRDs and T2DM, thus proposing AD as type 3 diabetes.