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Energy Metabolism In Heart Failure

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Cardiac Energy Metabolism in Health and Disease

Cardiac Energy Metabolism in Health and Disease Book
Author : Gary D. Lopaschuk,Naranjan S. Dhalla
Publisher : Springer
Release : 2014-08-22
ISBN : 1493912275
Language : En, Es, Fr & De

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Book Description :

The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.

Heart Failure A Companion to Braunwald s Heart Disease E book

Heart Failure  A Companion to Braunwald s Heart Disease E book Book
Author : Douglas L. Mann
Publisher : Elsevier Health Sciences
Release : 2010-11-11
ISBN : 1437703631
Language : En, Es, Fr & De

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Book Description :

Dr. Douglas L. Mann, one of the foremost experts in the field, presents the 2nd Edition of Heart Failure: A Companion to Braunwald’s Heart Disease. This completely reworked edition covers the scientific and clinical guidance you need to effectively manage your patients and captures the dramatic advances made in the field over the last five years. Now in full color, this edition features eleven new chapters, including advanced cardiac imaging techniques, use of biomarkers, cell-based therapies and tissue engineering, device therapies, and much more. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Use this Braunwald’s companion as the definitive source to prepare for the ABIM’s new Heart Failure board exam. Access the fully searchable contents of the book online at Expert Consult. This edition includes 67 new authors, who are experts in the field of heart failure Stay on the cutting edge with new chapters on: The latest practice guidelines for medical and device therapy Hemodynamic assessment of heart failure Contemporary medical therapy for heart failure patients with reduced and preserved ejection fraction Biomarkers in heart failure Pulmonary hypertension Management of co-morbidities in heart failure Mechanical cardiac support devices Get up to speed with the latest clinical trials, as well as how they have influenced current practice guidelines Explore what’s changing in key areas such as basic mechanisms of heart failure, genetic screening, cell and gene therapies, pulmonary hypertension, heart failure prevention, co-morbid conditions, telemedicine/remote monitoring, and palliative care

The Sinatra Solution

The Sinatra Solution Book
Author : Stephen T. Sinatra, M.D.
Publisher : ReadHowYouWant.com
Release : 2009-04-24
ISBN : 1442975016
Language : En, Es, Fr & De

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Book Description :

Board-certified cardiologist Dr. Stephen T. Sinatra discusses the importance of energy metabolism on cardiovascular health and the positive impact these three energy-supplying nutrients have on the cardiovascular system. He guides you through the basics of energy metabolism and cardiac bioenergetics, and clearly explains the role of coenzyme Q10, L-carnitine, and D-ribose in the body and specifically how they affect your heart health. He also provides concise and informative examples of case histories and scientific studies that are testament to the important contribution the supplemental use of these energy-supplying nutrients make in the lives of people with heart disease every day.

Metabolism and Nutrition for the Surgical Patient Part II An Issue of Surgical Clinics E Book

Metabolism and Nutrition for the Surgical Patient  Part II  An Issue of Surgical Clinics   E Book Book
Author : Stanley Dudrick
Publisher : Elsevier Health Sciences
Release : 2011-08-28
ISBN : 145570928X
Language : En, Es, Fr & De

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Book Description :

This Surgical Clinics issue is Part 2 of a special two part issue on nutrition and metabolism of the surgical patient, co-guest edited by Dr. Stanley Dudrick, a pioneer in total parenteral nutrition. Part 2, guest edited by Dr. Dudrick and Dr. Juan Sanchez present topics on nutrition and metabolism for the chronically ill patient. Topics will include: nutrition management of acute and chronic pancreatitis, surgical treatment of patients with diabetes mellitus, nutrition management of geriatric surgical patients, nutrients, routes of delivery and immunocompetence, immunologic functions and aspects of the alimentary tract related to feeding, overview of enteral and parenteral feeding access techniques, dietary, metabolic and surgical management of obese patients, historical highlights of the development of total parenteral nutrition, nutrition support of patients with cardiovascular disease, genomic and epigenomic aspects of nutrition and metabolism in surgical patients, nutrition support of patients with inflammatory bowel disorders of the small intestine, colon and rectum, nutrition support of patients with cancer, home parenteral nutrition for intestinal failure, and more.

Heart Failure

Heart Failure Book
Author : José Marín-García
Publisher : Springer Science & Business Media
Release : 2010-06-23
ISBN : 1607611473
Language : En, Es, Fr & De

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Book Description :

Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease. An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and future therapies. Heart Failure: Bench to Bedside includes a primer on gene profiling and bioenergetics of the normal heart and a discussion of the molecular, genetic, biochemical and cellular techniques critical to understanding HF. Further chapters discuss cardiac remodeling, oxidative stress, and alterations in other organs and systems that are often associated with HF. This book thoughtfully evaluates current and forthcoming diagnostic techniques and therapies, pharmaceutical and pharmacogenomic-based individualized medicine, gene and cell-based therapies, and the search for new frontiers. Heart Failure: Bench to Bedside presents a clear view of up-to-date approaches to clinical diagnosis and treatment, as well as offering insightful critiques of original and creative scientific thoughts on post-genomic HF research.

Heart Failure

Heart Failure Book
Author : Douglas L. Mann
Publisher : W B Saunders Company
Release : 2004
ISBN :
Language : En, Es, Fr & De

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Book Description :

Provides readers with a comprehensive bench-to-bench overview of the field of heart failure. Every attempt has been made to include novel chapters that have not heretofore been covered in traditional textbooks on heart failure. For example, one chapter addresses the new and emerging area of sleep-disordered breathing and heart. There are also unique chapters on the science and art of developing heart failure guidelines, as well as a chapter on clinical trial design in heart failure.

Glucolipotoxicity and the Heart An Issue of Heart Failure Clinics E Book

Glucolipotoxicity and the Heart  An Issue of Heart Failure Clinics   E Book Book
Author : Peter P. Toth,Vasudevan A. Raghavan
Publisher : Elsevier Health Sciences
Release : 2012-10-14
ISBN : 1455747114
Language : En, Es, Fr & De

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Book Description :

Chronic overconsumption of sugar and fat elevates plasma levels of insulin and free fatty acids, a process referred to as glucolipotoxicity. This phenomenon may lead to heart failure. This issue explores in depth the relationship between glucolipotoxicity and heart failure.

Exercise and Rehabilitation in Heart Failure An Issue of Heart Failure Clinics

Exercise and Rehabilitation in Heart Failure  An Issue of Heart Failure Clinics  Book
Author : Ross Arena
Publisher : Elsevier Health Sciences
Release : 2014-12-26
ISBN : 0323341934
Language : En, Es, Fr & De

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Book Description :

This multidisciplinary issue of Heart Failure Clinics examines a critical element in the management and treatment of heart failure (HF)—exercise and rehabilitation. Topics include the reversal of HF-associated pathophysiology with exercise; quantifying function; prognosis; rehabilitation practice patterns in the United States, Canada, South America, Asia, and Europe; special considerations such as obesity, high-intensity interval training, inspiratory muscle training, and technology to promote and increase physical activity.

Cardiovascular Magnetic Resonance

Cardiovascular Magnetic Resonance Book
Author : Warren J. Manning,Dudley J. Pennell
Publisher : Elsevier Health Sciences
Release : 2018-04-26
ISBN : 0323497373
Language : En, Es, Fr & De

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Book Description :

Provides state-of-the-art coverage of CMR technologies and guidelines, including basic principles, imaging techniques, ischemic heart disease, right ventricular and congenital heart disease, vascular and pericardium conditions, and functional cardiovascular disease. Includes new chapters on non-cardiac pathology, pacemaker safety, economics of CMR, and guidelines as well as new coverage of myocarditis and its diagnosis and assessment of prognosis by cardiovascular magnetic resonance, and the use of PET/CMR imaging of the heart, especially in sarcoidosis. Features more than 1,100 high-quality images representing today’s CMR imaging. Covers T1, T2 and ECV mapping, as well as T2* imaging in iron overload, which has been shown to save lives in patients with thalassaemia major Discusses the cost-effectiveness of CMR.

Oxford Textbook of Heart Failure

Oxford Textbook of Heart Failure Book
Author : Theresa A. McDonagh,Roy S. Gardner,Andrew L. Clark,Henry Dargie
Publisher : Oxford University Press
Release : 2011-07-14
ISBN : 0199577722
Language : En, Es, Fr & De

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Book Description :

The Oxford Textbook of Heart Failure takes the reader from an understanding of the basic mechanisms of heart failure, through to an appreciation of the complexities of heart failure management and the improvements possible with good treatment. Written by internationally renowned leaders in the field, this definitive textbook comprehensively covers all aspects necessary to manage a patient with heart failure, and is essential reading for consultant cardiologists, those in training, general physicians and those caring of the elderly, cardiothoracic surgeons, primary care doctors, pharmacists, and specialist nurses. The online version of the Oxford Textbook of Heart Failure contains the full text of the print edition (which can be browsed by the contents list or searched), links from references in the text to external sources (via PubMed, ISI, and CrossRef), and over 300 figures and illustrations from the print edition, downloadable into PowerPoint.

Cardiology

Cardiology Book
Author : Kanu Chatterjee
Publisher : JP Medical Ltd
Release : 2012-08-31
ISBN : 9350252759
Language : En, Es, Fr & De

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Book Description :

This two volume set presents recent advances in the knowledge and technology related to the field of cardiology. Beginning with a basic introduction, the text continues with a step by step approach through the subject, covering topics such as cardiovascular pharmacology, electrophysiology, coronary heart diseases, myocardial and pericardial disease and more. With contributions from leading international experts and over 1500 colour photographs, each chapter contains additional comments and guidelines from reputed international bodies. The book is accompanied by a DVD ROM containing high quality video footage of echocardiography.

Myocardial Ischemia Mechanisms Reperfusion Protection

Myocardial Ischemia  Mechanisms  Reperfusion  Protection Book
Author : Morris Karmazyn
Publisher : Springer Science & Business Media
Release : 1996-08-28
ISBN : 9783764352691
Language : En, Es, Fr & De

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Book Description :

Myocardial ischemia and subsequent reperfusion of the ischemic myocardium represent complex phenomena encompassing numerous physiological processes. This book aims at enhancing our understanding of these processes and stresses recent important developments in this very active area of research. The concise, state-of-the-art reviews cover recent advances in many fields important to the area of myocardial ischemia and reperfusion including physiology, pathology, pharmacology, biochemistry and molecular biology with reference to clinical relevance and applicability of these findings. Major areas which are highlighted include vascular mechanisms resulting in myocardial ischemia, cellular events in the ischemic, postinfarcted and reperfused myocardium as well as new exciting developments in cardiac protection that involve both novel pharmacological approaches as well as endogenous cardioprotective mechanisms such as preconditioning. Aimed at both the basic and clinical cardiovascular investigator, the book comprehensively reviews the rapid progress made in recent years in understanding the etiology of myocardial ischemia and reperfusion. It will further serve as an authoritative reference for all those interested in learning about the important developments in the treatment of myocardial ischemic and reperfusion disorders.

Inflammation in Heart Failure

Inflammation in Heart Failure Book
Author : Matthijs Blankesteijn,Raffaele Altara
Publisher : Academic Press
Release : 2014-12-05
ISBN : 0128004851
Language : En, Es, Fr & De

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Book Description :

Inflammation in Heart Failure, edited by W. Matthijs Blankesteijn and Raffaele Altara, is the first book in a decade to provide an in-depth assessment on the causes, symptoms, progression and treatments of cardiac inflammation and related conditions. This reference uses two decades of research to introduce new methods for identifying inflammatory benchmarks from early onset to chronic heart failure and specifically emphasizes the importance of classifying at-risk subgroups within large populations while determining the patterns of cytokines in such classifications. Further, the book details clinical applications of the pathophysiological mechanisms of heart failure, diagnosis and therapeutic strategies. Inflammation in Heart Failure’s breadth of subject matter, easy-to-follow structure, portability, and high-quality illustrations create an accessible benefit for researchers, clinicians and students. Presents updated information and research on the relevant inflammatory mediators of heart failure to aid in targeting future translational research as well as the improvement of early diagnosis and treatment Provides research into better understanding the different inflammatory mediators that signal the underlying diseases that potentially lead to heart failure Contains 20 years of research, offering a brief overview of the topic leading to current opinions on, and treatment of, heart failure Provides a structured, systematic and balanced overview of the role of inflammation in heart failure making it a useful resource for researchers and clinicians, as well as those studying cardiovascular diseases

Textbook of Veterinary Internal Medicine eBook

Textbook of Veterinary Internal Medicine   eBook Book
Author : Stephen J. Ettinger,Edward C. Feldman
Publisher : Elsevier Health Sciences
Release : 2009-12-24
ISBN : 1437702821
Language : En, Es, Fr & De

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Book Description :

Now in its 7th edition, this popular, must-have text remains the only encyclopedic resource for veterinary internal medical problems. The internationally acclaimed "gold standard" offers unparalleled coverage of pathophysiology, diagnosis, and treatment of diseases affecting dogs and cats, as well as the latest information on the genome, clinical genomics, euthanasia, innocent heart murmurs, hyperbaric medicine, home prepared and raw diets, obesity, botulism, artificial pacing of the heart, cancer vaccines, and more. The 7th edition combines the convenience of a two-volume printed textbook with the enhanced functionality of an Expert Consult website that enables you to electronically search your entire book and study more efficiently. With instant access to the most reliable information available, you’ll always be at the forefront of veterinary care! Fully searchable online text provides fast, easy access to the most reliable information in the field. More than 150 clinical algorithms throughout the text aid in disease-identification and decision-making. Expanded online chapter content enhances your understanding through additional text, illustrations, tables, and boxes. Hyperlinked client information sheets streamline reference of specific conditions and enhance communication with clients. Extensive online reference list directs you to full-text PubMed abstracts for additional research. Thoroughly updated and expanded content, including 90 new chapters, addresses the latest developments across the full spectrum of small animal care. Companion Expert Consult website enhances your learning experience with the ability to search the entire electronic text instantly for easy reference. Expert Consult also gives you instant access to: More than 150 procedural videos that guide you step-by-step through essential procedures. Audio files that help you identify heart abnormalities by their sound.

Annual Update in Intensive Care and Emergency Medicine 2011

Annual Update in Intensive Care and Emergency Medicine 2011 Book
Author : Jean-Louis Vincent
Publisher : Springer Science & Business Media
Release : 2011-04-02
ISBN : 9783642180811
Language : En, Es, Fr & De

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Book Description :

The Annual Update compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

Translational Cardiology

Translational Cardiology Book
Author : Cam Patterson,Monte S. Willis
Publisher : Springer Science & Business Media
Release : 2012-07-04
ISBN : 1617798916
Language : En, Es, Fr & De

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Book Description :

Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques provides an up-to-date introduction to the role circadian rhythms, cardiac plasticity, and mechanotransduction play in the heart, while at the same time introducing new developments in cellular, viral, and non-biologic therapies that are in the process of being developed. Importantly, the focus of this book is on topics that, due to their novelty, are largely not covered in the other major textbooks. A special emphasis is placed on the molecular basis of cardiac metabolism, new concepts in cardiac remodeling, and translational therapies and imaging techniques currently under development for clinical use. The chapters are written by experts from diverse clinical and biomedical research backgrounds. Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques simplifies the complexity of the molecular basis of disease by focusing on patient-oriented disease mechanisms and therapies and is of great value to a broad audience including physicians (e.g. cardiologists, cardiovascular surgeons, pathologists) as well as translational biomedical researchers in a wide range of disciplines.

Inherited Metabolic Epilepsies

Inherited Metabolic Epilepsies Book
Author : Phillip L. Pearl, MD
Publisher : Demos Medical Publishing
Release : 2012-10-04
ISBN : 1617050563
Language : En, Es, Fr & De

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Book Description :

The explosion of information in neurogenetics and metabolism mandates increasing awareness of appropriate diagnostic and therapeutic strategies in the setting of certain epilepsies, especially those of very early onset. There are over 200 inherited disorders that are associated with seizures and prompt identification and intervention is crucial for a positive outcome. This text brings together leading authorities presenting state-of-the-art clinical reviews covering the science, recognition, and treatment of the inherited metabolic epilepsies and related disorders. Inherited Metabolic Epilepsies opens with a section on general principles for diagnosis and targeted intervention including screening protocols, laboratory testing, neuroimaging, seizure patterns and EEG findings, new technologies, and the ketogenic diet in metabolic epilepsies. The next two sections are devoted to the cohort of specific small molecule disorders (aminoacidopathies, organic acidopathies, mitochondrial disorders, urea cycle disorders, neurotransmitter disorders, and glucose-related disorders) and large molecule disorders (lysomal storage disorders, peroxisomal diseases, glycosylation defects, and leukodystrophies) that are treatable yet can be so vexing to clinicians and investigators. The book concludes with a clinical algorithm designed to be a resource for the physician in search of direction when considering an inherited metabolic disorder as the explanation for a patient with epilepsy. Inherited Metabolic Epilepsies Key Features: Presents the latest scientific thinking and clinical wisdom for a poorly understood group of disorders that have devastating consequences if unrecognized or not promptly treated Expert authorship from both the genetic-metabolic and epilepsy communities provides state-of-the-art guidance for understanding and managing these disorders A readable text for clinicians highlighting the relation between metabolic errors and epilepsy Concludes with a practical algorithm for evaluating a patient with a possible metabolic epilepsy