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Endothelium And Cardiovascular Diseases

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The Endothelium in Cardiovascular Disease

The Endothelium in Cardiovascular Disease Book
Author : Thomas Luescher
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642798039
Language : En, Es, Fr & De

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Book Description :

Since the endothelium plays such an important role in the pathophysiology of the circulatory system, the readers attention is directed here towards the possible involvement of these polypeptides in the aetiology of ischaemic heart disease, cerebrovascular accidents, hypertension, atherosclerosis and renal failure.

Endothelium and Cardiovascular Diseases

Endothelium and Cardiovascular Diseases Book
Author : Protasio Lemos Da Luz,Peter Libby,Francisco Rafael Martins Laurindo,Antonio Carlos Palandri Chagas
Publisher : Academic Press
Release : 2018-02-03
ISBN : 0128125519
Language : En, Es, Fr & De

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Book Description :

Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes

Inflammation in Cardiovascular Diseases Role of the Endothelium Emerging Therapeutics

Inflammation in Cardiovascular Diseases  Role of the Endothelium   Emerging Therapeutics Book
Author : Chen Huei Leo,Cheng Xue Helena Qin,Owen Llewellyn Woodman
Publisher : Frontiers Media SA
Release : 2021-01-05
ISBN : 2889663426
Language : En, Es, Fr & De

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Book Description :

Download Inflammation in Cardiovascular Diseases Role of the Endothelium Emerging Therapeutics book written by Chen Huei Leo,Cheng Xue Helena Qin,Owen Llewellyn Woodman, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Endothelium and Cardiovascular Diseases

Endothelium and Cardiovascular Diseases Book
Author : Anonim
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Endothelium and Cardiovascular Diseases book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Endothelium and Cardiovascular Diseases

Endothelium and Cardiovascular Diseases Book
Author : Protasio Lemos Da Luz,Peter Libby,Francisco Rafael Martins Laurindo,Antonio Carlos Palandri Chagas
Publisher : Academic Press
Release : 2018-01-19
ISBN : 9780128123485
Language : En, Es, Fr & De

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Book Description :

Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes

Vascular Endothelium in Human Physiology and Pathophysiology

Vascular Endothelium in Human Physiology and Pathophysiology Book
Author : Patrick J Vallance,David J. Webb
Publisher : CRC Press
Release : 2003-09-02
ISBN : 0203304950
Language : En, Es, Fr & De

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Book Description :

Endothelial dysfunction is now regarded as an early marker of vascular disease and therefore an important target for therapeutic intervention and discovery of novel treatments. Ideal for both basic and clinical scientists, whether in industry or academia, and physicians, Vascular Endothelium in Human Physiology and Pathophysiology provides an up-to-date review of the vascular functions of the endothelium and its role in key areas of cardiovascular disease. It focuses on evidence from studies in humans.

Endothelial Dysfunction

Endothelial Dysfunction Book
Author : Helena Lenasi
Publisher : BoD – Books on Demand
Release : 2018-10-24
ISBN : 1789842530
Language : En, Es, Fr & De

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Book Description :

The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.

Endothelial Dysfunctions in Vascular Disease

Endothelial Dysfunctions in Vascular Disease Book
Author : Raffaele De Caterina,Peter Libby
Publisher : John Wiley & Sons
Release : 2008-04-15
ISBN : 0470994096
Language : En, Es, Fr & De

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Book Description :

Bridging the gap between the laboratory and the bedside, this timely volume illuminates the connection between endothelial dysfunction and vascular disease. This comprehensive survey of atherosclerotic disease begins with biology – incorporating the latest breakthroughs in the field – then elucidates risk factors and diagnostic tools and markers. A major section on endothelium-directed prevention and therapy shows you how to apply cutting-edge research to clinical care. Under the careful editorial guidance of Drs. De Caterina and Libby, the highly-regarded contributors address: endothelial activation and the initiation of atherosclerosis mechanisms of plaque progression and complications the role of LDL in the origin and progression of atherosclerosis advanced glycation endproducts and the accelerated atherosclerosis in diabetes oxidative stress and vascular disease soluble adhesion molecules as markers of vascular disease hormone-replacement therapy and cardiovascular risk anti-oxidants and endothelial protection and more. The first book dedicated to the central role of endothelial dysfunction in vascular disease, this concise volume gathers all the latest information on the subject into one convenient and cohesive text. Make sure your patients are benefiting from current knowledge by keeping a copy of Enothelial Dysfunctions in Vascular Disease close at hand for frequent consultation. Introduction Every book has a history, this one not excepted, having emerged from intersections in professional lives of the Editors. This book bears the fruits of a collaboration between the “pupil” (RDC) and the “mentor” (PL). During an extended sabbatical of the pupil in Boston in 1994, we probed together the concept that endothelial dysfunction served as a common denominator of vascular disease, with the balance between inflammation and its inhibition as a fulcrum of the regulation of the behavior of endothelial cells. As practicing cardiologists in our clinical lives, we sought to link to endothelial function the mechanisms of action of risk factors and of pharmacologic agents used to treat and prevent vascular disease. The pupil therefore authored a few reviews on the mechanism of action of risk factors and included them in a small book, published in Italian, for which the mentor wrote a preface. The book was greeted with favor from the Italian cardiological community, and provided the nidus for the present, more ambitious endeavor, which includes updated reviews on the pathogenesis of vascular disease and on the most novel aspects of vascular biology. This enterprise was enabled by the contributions of many of our former or present collaborators and colleagues, without whose enthusiasm and engagement this work could never have seen light. We largely underestimated the devotion necessary on our own side at the beginning, but it ultimately yielded a product that we feel achieves our original goals. We are aware that we confront a continuously evolving topic, where frequent updates would be desirable - if not necessary. Yet, we believe in the value of books - such as the current one - that attempt to organize in a snapshot of time, the vast amount of literature available in a coherent and comprehensive scheme. We are aware of existing gaps, of emerging material not paid its due, and of the rapid evolution of some of the concepts highlighted within. The links between the laboratory and the clinic have never afforded more opportunity for new understanding and advances in diagnosis and treatment than today We hope that our colleagues, vascular biologists cardiologists, internists, and other physicians alike will find this compendium a useful guide to this most exciting time in vascular biology and medicine —Raffaele De Caterina and Peter Libby

Diabetes and Cardiovascular Disease

Diabetes and Cardiovascular Disease Book
Author : Michael T. Johnstone,Aristidis Veves
Publisher : Springer Science & Business Media
Release : 2007-10-28
ISBN : 1592599087
Language : En, Es, Fr & De

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Book Description :

The cause of diabetes mellitus is metabolic in origin. However, its major clinical manifestations, which result in most of the morbidity and mortality, are a result of its vascular pathology. In fact, the American Heart Association has recently stated that, “from the point of view of cardiovascular medicine, it may be appropriate to say, diabetes is a cardiovascular disease” (1). But diabetic vascular disease is not limited to just the macrovasculature. Diabetes mellitus also affects the microcirculation with devastating results, including nephropathy, neuropathy, and retinopathy. Diabetic nephropathy is the leading cause of end-stage renal disease in the United States, while diabetic retinopathy is the leading cause of new-onset blindness in working-age Americans. The importance of this text on Diabetes and Cardiovascular Disease is evident by the magnitude of the population affected by diabetes mellitus. Over 10 million Americans have been diagnosed with diabetes mellitus, while another 5 million remain undiagnosed. The impact from a public health perspective is huge and increasing. As the population of the United States grows older, more sedentary, and obese, the risk of developing diabetes and its complications will increase. Epidemiological studies have identified diabetes mellitus as a major independent risk factor for cardiovascular disease. Over 65% of patients with diabetes mellitus die from a cardiovascular cause. The prognosis of patients with diabetes mellitus who develop overt clinical cardiovascular disease is much worse than those cardiovascular patients free of diabetes mellitus.

The Endothelium in Cardiovascular Disease

The Endothelium in Cardiovascular Disease Book
Author : Thomas F. Luscher
Publisher : Unknown
Release : 1995-08-01
ISBN : 9780387593524
Language : En, Es, Fr & De

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Book Description :

Download The Endothelium in Cardiovascular Disease book written by Thomas F. Luscher, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Endothelial Dysfunction

Endothelial Dysfunction Book
Author : Trent H. Keaton
Publisher : Nova Science Pub Incorporated
Release : 2014-01-01
ISBN : 9781633212039
Language : En, Es, Fr & De

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Book Description :

The endothelium is a thin mono-cellular layer which covers the inner surface of the blood vessels, separating the circulating blood from the tissues and also has the responsibility for uninterrupted maintenance of circulation to all the vital tissues. Endothelium is a very active organ, it works as a receptor-effector organ and responds to each physical or chemical stimulus with the release of the appropriate substance with which it may maintain vasomotor balance and vascular-tissue homeostasis. It has the property of producing, independently, both agonistic and antagonistic substances that help to keep homeostasis and its function is not only autocrine, but also paracrine and endocrine. In this way it modulates the vascular smooth muscle cells producing relaxation or contraction, and therefore vasodilatation or vasoconstriction. The vascular endothelium is vulnerable to maximum wear and tear due to its positioning and requires prompt regeneration of the cells. Whenever the imbalance between substances with vasodilating, antimitogenic, and antithrombogenic properties and substances with vasoconstricting, prothrombotic and proliferative characteristics takes place, it causes a pathological condition known as endothelial dysfunction. These substances intervenes in cell proliferation and migration, in leukocyte adhesion and activation and in immunological and inflammatory processes, further which is responsible for apoptosis of vascular endothelial cells resulting in overall endothelial dysfunction and vasculopathy. This book discusses, in further detail, the risk factors, and the role of endothelial dysfunction in cardiovascular diseases and therapeutic approaches to dealing with endothelial dysfunction.

Vascular Aging Facts and Factors

Vascular Aging  Facts and Factors Book
Author : Elisabet Vila,Francesc Jiménez-Altayó,Paula Dantas
Publisher : Frontiers E-books
Release : 2021-12-03
ISBN : 2889190528
Language : En, Es, Fr & De

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Book Description :

The increasing mean age of the population in developed countries has turned out to be an economic and social problem. Cardiovascular disease has long been considered to be age related in terms of their onset and progression. As such, we can say that the increase in life expectancy goes in parallel with increased incidence of cardiovascular disease. With age, a number of changes occur in the vasculature altering the homeostasis of the irrigated organs promoting target organ damage. While different adaptive mechanisms to protect vessels against mild stress have been described, the aging process induces a progressive failure of protective mechanisms, leading to vascular changes and higher susceptibility to cardiovascular diseases. Indeed, vascular aging is exacerbated by coexisting cardiovascular risk factors, such as hypertension, metabolic syndrome and diabetes. Compelling evidence indicates that diminished endothelial relaxation and increase, decrease, or no change in contractile responses to several agonists is associated with aging. There is an increase of vasoconstrictor factors expression and a decrease of vasodilators. Morphologic changes include lumen diameter enlargement, wall thickening and alterations of matrix substances as increased collagen or decreased elastin deposition, ultimately leading to greater arterial stiffening (reduced compliance). Importantly, arterial stiffness is an independent predictor of cardiovascular morbidity and mortality. Cellular and molecular mechanisms have also been documented. Senescence at the cellular level involves alterations in Ca2+ signaling and down regulation of anti-aging proteins. Both endothelial and smooth muscle cells change their number, morphology, function and their regenerative ability. Aging is also associated with a gradual loss of antioxidant defense mechanisms, a proinflammatory shift in the cytokine expression profile and a production of reactive oxygen species such as superoxide (O2-) that promotes the breakdown of nitric oxide. Nitric oxide and O2- interact to form peroxynitrite known to nitrosylate proteins affecting their physiological function. However, vascular wall proteins may also suffer from other potentially deleterious modifications as glycation (Maillard reaction) and glyco-oxidative reactions with increasing age, which could be linked to the age-associated changes in vascular function. Various strategies have shown benefit in preventing, delaying or attenuating vascular aging. For instance, a healthy lifestyle including low fat diet and/or exercise have a favorable effect. Nevertheless, it yet remains to be fully demonstrated whether vascular aging can be pharmacologically prevented. This Research Topic is intended to bring together research efforts to understand the causes and consequences of vascular aging and propose new therapeutic strategies for the management of vascular senescence.

Antioxidants and Cardiovascular Disease

Antioxidants and Cardiovascular Disease Book
Author : Jean-Claude Tardif,Martial G. Bourassa
Publisher : Springer Science & Business Media
Release : 2000
ISBN : 9780792365648
Language : En, Es, Fr & De

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Book Description :

This work addresses a complex problem in cardiovascular medicine. It is written by experts in the fields of atherosclerosis, heart failure, and antioxidants. It should be of interest not only to academicians but also to practising physicians, including postdoctoral fellows, internists, cardiologists, and general practitioners. The first three chapters review the antioxidant hypothesis and its close relationship to lipid mechanisms of action and classify the different and heterogeneous pharmacological compounds with known antioxidant properties, and describe the role of dietary nutrients and supplements as well as the potential therapeutic benefit of antioxidants in coronary artery disease prevention and risk reduction, prevention of endothelial dysfunction, and prevention of chronic heart failure. Finally, current knowledge of the use of these compounds in cardiovascular medicine is summarized.

Endothelial Vasoactive Substances and Cardiovascular Disease

Endothelial Vasoactive Substances and Cardiovascular Disease Book
Author : Thomas Felix Lüscher
Publisher : S Karger Ag
Release : 1988
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Endothelial Vasoactive Substances and Cardiovascular Disease book written by Thomas Felix Lüscher, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Endothelium Nitric Oxide and Atherosclerosis

Endothelium  Nitric Oxide and Atherosclerosis Book
Author : Julio Panza,Richard Cannon
Publisher : Blackwell Publishing
Release : 1999-06-18
ISBN : 9780879934361
Language : En, Es, Fr & De

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Book Description :

The opening chapter of this book, by scientist Dr. Robert Furchgott, details the discovery of endothelium’s role in the vasodilator effect of acetycholine in 1978. Its subsequent identification as nitric oxide has been critical to cardiovascular medicine in understanding the regulation of vascular homeostasis. This simple observation won Dr. Furchgott a Nobel Prize in 1998. Spanning from these initial observations to recent clinical investigations, this work offers an invaluable historical reference and clinical explanation about the intracellular mechanisms that regulate and stimulate endothelial nitric oxide synthase (eNOS). The basic mechanisms leading to endothelial dysfunction in cardiovascular disease complement information about the biological role and regulation of endothelial nitric oxide. Clinical studies of impaired endothelial function in patients with different cardiovascular conditions also reveal important and effective therapeutic strategies. Written for both established physicians and scientists investigating the basic mechanisms and treatment of cardiovascular disease, as well as medical students who want to initiate themselves in the study of endothelial regulation of vascular physiology, many will find this comprehensive review a stimulus for new research.

Endothelial Function and Cardiovascular Disease

Endothelial Function and Cardiovascular Disease Book
Author : Arduino Mangoni
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Endothelial Function and Cardiovascular Disease book written by Arduino Mangoni, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Endothelial Function in Cardiovascular Disease

Endothelial Function in Cardiovascular Disease Book
Author : Haralambos Gavras,Irene Gavras
Publisher : Unknown
Release : 1996
ISBN : 9781858731384
Language : En, Es, Fr & De

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Book Description :

Download Endothelial Function in Cardiovascular Disease book written by Haralambos Gavras,Irene Gavras, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cardiovascular Disease and Endothelium

Cardiovascular Disease and Endothelium Book
Author : Anonim
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cardiovascular Disease and Endothelium book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Association of Adiponectin with Cardiovascular Disease and Endothelial Progenitor Cell

The Association of Adiponectin with Cardiovascular Disease and Endothelial Progenitor Cell Book
Author : Mingfang Li
Publisher : Open Dissertation Press
Release : 2017-01-27
ISBN : 9781374706163
Language : En, Es, Fr & De

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Book Description :

This dissertation, "The Association of Adiponectin With Cardiovascular Disease and Endothelial Progenitor Cell" by Mingfang, Li, 酈明芳, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b4357236 Subjects: Adipose tissues Vascular endothelium Cardiovascular system - Diseases

Neurohumoral Regulation of Coronary Flow

Neurohumoral Regulation of Coronary Flow Book
Author : W. H. (Wiek) van Gilst,K.J. Lie
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 9401119007
Language : En, Es, Fr & De

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Book Description :

During the last decade we have witnessed a rapid expansion of our knowledge of the role of the endothelium in the control of vascular tone and hemostasis. In paricular, developments in molecular biology have enabled us to understand its physiology in greater detail. Furthermore, it is now clear that dysfunction of the endothelium contributes to various cardiovascular diseases. This is especially true for the coronary vascular bed. Development of atherosclerosis, disturbed vasomotor tone in stable ischemic syndromes, and the interaction of thrombocytes with the endothelium in acute ischemic syndrome are all consequences of endothelium dysfunction. Also, secondary changes in endothelial function have been described, for instance in chronic heart failure. This monograph reviews the present knowledge of the role of the endothelium in the control of coronary flow. The authors lead the reader through this topic starting at the basic physiology of endothelial function and the principles of coronary flow regulation. Next, the use of modern clinical techniques to evaluate endothelial function such as positron emission tomography and angioscopy are discussed. Subsequently, several pathophysiological processes and the role of endothelium are addressed. Finally, the interaction of various presently used cardiovascular drugs with the endothelium is indicated. It is the combination of basic sciences with clinical observations in this book which may be appreciated by a large number of scientists and physicians active in the field of cardiovascular disease. It is also this combination of different disciplines which will determine future developments and new avenues in pharmacotherapy involving the endothelium.