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Endothelial Signalling In Vascular Dysfunction And Disease

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Endothelial Signaling in Vascular Dysfunction and Disease

Endothelial Signaling in Vascular Dysfunction and Disease Book
Author : Shampa Chatterjee
Publisher : Academic Press
Release : 2020-12-01
ISBN : 0128163828
Language : En, Es, Fr & De

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Book Description :

Endothelial Signaling in Vascular Dysfunction and Disease: From Bench to Bedside provides a detailed understanding of the endothelium, its activation and their link to some common clinical disorders. In addition, the book covers earlier discoveries, including those from the last and 19th centuries. It is split into five sections that cover the vascular tree as an integrative structure, the endothelium in inflammation, endothelial signaling, activation and toxicity with chemotherapy, radiation induced endothelial dysfunction and vascular disease, and therapies in combating vascular diseases. Each section is discussed with a translational approach in order to make the content truly applicable. This book is a valuable source for basic researchers, clinicians in the fields of Oncology, Cardiovascular Medicine and Radiology, and members of the biomedical field who are conducting studies related to the endothelium and vascular disease. Discusses the most relevant discoveries in endothelial biology and their link to manifestations of clinical disease Presents history and diagrams in each section to highlight the original biological discovery and its link of clinical manifestations of vascular disease Includes recent findings on the relationship between endothelial signaling, chemotherapy and radiation induced endothelial dysfunction

Endothelial Signalling in Vascular Dysfunction and Disease

Endothelial Signalling in Vascular Dysfunction and Disease Book
Author : Shampa Chatterjee
Publisher : Academic Press
Release : 2020-08
ISBN : 9780128161968
Language : En, Es, Fr & De

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Book Description :

Endothelial Signaling in Vascular Dysfunction and Disease: From Bench to Bedside provides a detailed understanding of the endothelium, its activation and their link to some common clinical disorders. In addition, the book covers earlier discoveries, including those from the last and 19th centuries. It is split into five sections that cover the vascular tree as an integrative structure, the endothelium in inflammation, endothelial signaling, activation and toxicity with chemotherapy, radiation induced endothelial dysfunction and vascular disease, and therapies in combating vascular diseases. Each section is discussed with a translational approach in order to make the content truly applicable. This book is a valuable source for basic researchers, clinicians in the fields of Oncology, Cardiovascular Medicine and Radiology, and members of the biomedical field who are conducting studies related to the endothelium and vascular disease. Discusses the most relevant discoveries in endothelial biology and their link to manifestations of clinical disease Presents history and diagrams in each section to highlight the original biological discovery and its link of clinical manifestations of vascular disease Includes recent findings on the relationship between endothelial signaling, chemotherapy and radiation induced endothelial dysfunction

Endothelial Signaling in Development and Disease

Endothelial Signaling in Development and Disease Book
Author : Mirko HH Schmidt,Stefan Liebner
Publisher : Springer
Release : 2015-10-08
ISBN : 1493929070
Language : En, Es, Fr & De

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Book Description :

This book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, lymphangiogenesis, junctional signaling, the extracellular matrix, vascular permeability, leukocyte extravasation, axon guidance factors, the angiopoietin system, and chronic obstructive lung disease. Following a preface from leading researcher Dr. Holger Gerhardt, the text is divided into three sections- the first examining the development of the vascular system in a variety of contexts, the second delving into its homeostatic characteristics, and the third discussing its pathophysiologies. The sixteen chapters, which represent international clinical and research perspectives, highlight the importance of molecular and signaling pathways for translational basic science and clinical medicine. Additionally, the text explores new and exciting fields in vascular biology research. Comprehensive in both content and approach, Vascular Signaling in Health and Disease is ideal for graduate students, researchers, and clinicians interested in vascular biology, pneumology, and molecular biology.

Endothelial Cells in Health and Disease

Endothelial Cells in Health and Disease Book
Author : William C. Aird
Publisher : CRC Press
Release : 2005-02-28
ISBN : 1135534608
Language : En, Es, Fr & De

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Book Description :

This reference serves as the first source to gather current data from endothelial cell biologists in various disciplines to summarize recent progress in the field-providing a complete understanding of the endothelium in health and disease and demonstrating its potential as a therapeutic target.

Microvascular Research Biology and Pathology Two Volume Set

Microvascular Research  Biology and Pathology  Two Volume Set Book
Author : David Shepro
Publisher : Elsevier
Release : 2005-11-17
ISBN : 0126395101
Language : En, Es, Fr & De

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Book Description :

The microvasculature refers to the smallest blood vessels, arterial and venous, that nurture the tissues of each organ. Apart from transport, they also contribute to the systematic regulation of the body. In everyday terminology, the microcirculation is "where the action is." Microcirculation is directly involved in such disease states as Alzheimers, inflammation, tumor growth, diabetic retinopathy, and wound healing- plus cardiovascular fitness is directly related to the formation of new capillaries in large muscles. Microvascular Research is the first book devoted exclusively to this vital systemic component of the cardiovascular system and provides up to date mini-reviews of normal functions and clinical states. The contributing authors are senior scientists with international reputation in their given disciplines. This two-volume set is a broad, interdisciplinary work that encompasses basic research and clinical applications equally. * Broad coverage of both basic and clinical aspects of microvasculature research * Contains 167 chapters from over 300 international authors * Each chapter includes key figures and annotated references

Textbook of Vascular Medicine

Textbook of Vascular Medicine Book
Author : Rhian M. Touyz,Christian Delles
Publisher : Springer
Release : 2019-08-02
ISBN : 3030164810
Language : En, Es, Fr & De

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Book Description :

This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.

Endothelium and Cardiovascular Diseases

Endothelium and Cardiovascular Diseases Book
Author : Protasio Lemos Da Luz,Peter Libby,Francisco Rafael Martins Laurindo,Antonio Carlos Palandri Chagas
Publisher : Academic Press
Release : 2018-02-03
ISBN : 0128125519
Language : En, Es, Fr & De

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Book Description :

Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes

Extracellular ATP and adenosine as regulators of endothelial cell function

Extracellular ATP and adenosine as regulators of endothelial cell function Book
Author : Evgenia Gerasimovskaya,Elzbieta Kaczmarek
Publisher : Springer Science & Business Media
Release : 2010-04-26
ISBN : 9789048134359
Language : En, Es, Fr & De

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Book Description :

Extracellular purines and pyrimidines (ATP, ADP, UTP and adenosine) are released into the extracellular milieu in response to a variety of stress conditions and act as important regulators of vascular homeostasis. This new book is uniquely focused on the signaling actions of extracellular purines in endothelial cells and the crucial role of extracellular purines in regulation of angiogenesis, vascular tone, cell permeability, wound healing, inflammation and cell-to-cell communication. This book examines the responses of endothelial cells, originating from various tissues (such as cornea, pancreas and uterus), to extracellular nucleotides and adenosine under physiological and pathological conditions, i.e. pregnancy, hypoxia, hypertension, inflammation and diabetes. In the book’s 12 chapters, the role of purinergic signaling in endothelium-dependent tissue perfusion, regulation of endothelial barrier function, and angiogenesis are discussed. The mechanisms of ATP release and its role in intercellular communication are also presented. In addition, the book provides the most up to date mechanisms of extracellular nucleotide metabolism by purine-converting ecto-enzymes and their contribution to purinergic signaling in endothelial cells originating from various vascular beds. This book is a valuable resource for biomedical research scientists, clinical scientists, graduate students and health science professionals interested in the mechanisms of extracellular purine function in endothelial cells under physiologic and pathologic conditions.

Arterial Aging and Age Associated Arterial Diseases

Arterial Aging and Age Associated Arterial Diseases Book
Author : Mingyi Wang,Jiguang Wang,Gianfranco Pintus,Cuntai Zhang
Publisher : Frontiers Media SA
Release : 2019-01-24
ISBN : 2889456927
Language : En, Es, Fr & De

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Book Description :

The underlying mechanisms behind aging has long been a great scientific mystery that the biomedical research community has long studied. In developed nations, as the population grows older, increases in life expectancy is increasingly limited by our relatively poor control of chronic aging-associated diseases such as arterial aging. Among age-related conditions that negatively influence longevity. Growing evidence demonstrates that arterial aging is fundamentally caused by a proinflammatory process that begins at birth and results in detrimental effects that affects every organ system. Vascular aging is the leading risk factor for quintessential cardiovascular diseases such as hypertension and atherosclerosis. With aging, vascular walls develop a pro-inflammatory and stressed microenvironment characterized by both an upregulation of pro-inflammatory chemokines and cytokines as well as a down-regulation anti-inflammatory counterparts. This chronic imbalance in inflammatory regulatory networks is the key driver of changes at the cellular and molecular level that result in hypertensive and atherosclerotic arterial. Thus, an intervention of proinflammation may be a viable therapeutic intervention to reduce morbidity and mortality from cardiovascular diseases. In this eBook, we aim to supply an updated overview of the physiological and biochemical mechanisms that affect inflammation and vascular aging. We believe that this eBook will contribute to the understanding of the pathogenesis of many chronic or age-related diseases, as well as to their treatment with both current and new therapeutic approaches.

Heart Failure A Companion to Braunwald s Heart Disease E book

Heart Failure  A Companion to Braunwald s Heart Disease E book Book
Author : Douglas L. Mann
Publisher : Elsevier Health Sciences
Release : 2010-11-11
ISBN : 1437703631
Language : En, Es, Fr & De

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Book Description :

Dr. Douglas L. Mann, one of the foremost experts in the field, presents the 2nd Edition of Heart Failure: A Companion to Braunwald’s Heart Disease. This completely reworked edition covers the scientific and clinical guidance you need to effectively manage your patients and captures the dramatic advances made in the field over the last five years. Now in full color, this edition features eleven new chapters, including advanced cardiac imaging techniques, use of biomarkers, cell-based therapies and tissue engineering, device therapies, and much more. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Use this Braunwald’s companion as the definitive source to prepare for the ABIM’s new Heart Failure board exam. Access the fully searchable contents of the book online at Expert Consult. This edition includes 67 new authors, who are experts in the field of heart failure Stay on the cutting edge with new chapters on: The latest practice guidelines for medical and device therapy Hemodynamic assessment of heart failure Contemporary medical therapy for heart failure patients with reduced and preserved ejection fraction Biomarkers in heart failure Pulmonary hypertension Management of co-morbidities in heart failure Mechanical cardiac support devices Get up to speed with the latest clinical trials, as well as how they have influenced current practice guidelines Explore what’s changing in key areas such as basic mechanisms of heart failure, genetic screening, cell and gene therapies, pulmonary hypertension, heart failure prevention, co-morbid conditions, telemedicine/remote monitoring, and palliative care

Endothelial Dysfunction During Inflammation and Alloimmunity

Endothelial Dysfunction During Inflammation and Alloimmunity Book
Author : Olaf Penack,Thomas Luft
Publisher : Frontiers Media SA
Release : 2019-04-09
ISBN : 2889458261
Language : En, Es, Fr & De

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Book Description :

Endothelial cells form the inner lining of blood and lymphatic vessels and they have frequent interactions with immune cells as well as foreign agents. Endothelial function is crucially involved in physiologic immunity at different stages including recruitment of leukocytes, angiogenesis and tissue repair. Endothelial dysfunction is a not well-defined term, it is widely used to describe the non-physiologic activity of endothelial cells. It has been suggested that endothelial dysfunction plays a role in a variety of human diseases, such as arteriosclerosis, cancer, autoimmunity and sepsis. More recently, a role of lymphatic endothelial cells as well as vascular endothelial cells in the pathophysiology of inflammation and allo-immune reactions has been suggested. Development of novel therapeutic approaches to normalize endothelial dysfunction is currently an unmet medical need. Until now, the cellular and molecular mechanisms of mutual influences between endothelial dysfunction and human diseases remain largely unexplored, constituting a frontier hindering the development of new therapies. This Research Topic aims to build a forum for a wide range of scientific studies in the fields of endothelial dysfunction during inflammatory diseases and transplantation.

Metabolic Syndrome and Cardiovascular Disease

Metabolic Syndrome and Cardiovascular Disease Book
Author : T. Barry Levine,Arlene Bradley Levine
Publisher : John Wiley & Sons
Release : 2012-07-05
ISBN : 1118480074
Language : En, Es, Fr & De

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Book Description :

Trends indicate that the metabolic syndrome will become theleading risk factor for heart disease. Now more than ever you needan all-in-one reference that provides the tools and practicaladvice you need to: Identify at-risk patients Explain individual contributing factors Aid in patient education and motivation Direct comprehensive care and Choose the most appropriate interventions Comprehensively revised to reflect leading-edge research and noworganized to facilitate easy access to essential information andclinically-relevant guidance, Metabolic Syndrome andCardiovascular Disease, 2e offers this and more. Not onlywill you receive a solid understanding of the pathophysiologyunderlying the metabolic syndrome and cardiovascular disease butalso the rationale for today’s most effectivetreatments. What’s new? Filled with timely new content, this updated edition covers: New discoveries that have changed our understanding of thepathogenesis and interrelationship of metabolic syndrome,cardiovascular disease (CHD), and type 2 diabetes mellitus(DM) The relevance of mitochondria and telomeres Sleep and its impact on cardiometabolic health The pivotal interplay between insulin and forkheadtranscriptionfactors Calorie restriction research Bariatric surgery experiences and outcomes In addition, each chapter includes essential information oncomorbidities, interventions, and pharmacotherapeutic options– an exclusive feature found only in the second edition!

Cellular and Molecular Pathobiology of Cardiovascular Disease

Cellular and Molecular Pathobiology of Cardiovascular Disease Book
Author : Monte Willis,Jonathon W. Homeister,James R. Stone
Publisher : Academic Press
Release : 2013-12-23
ISBN : 0124055257
Language : En, Es, Fr & De

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Book Description :

Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Sphingosine 1 Phosphate Signaling in Immunology and Infectious Diseases

Sphingosine 1 Phosphate Signaling in Immunology and Infectious Diseases Book
Author : Michael B. A. Oldstone,Hugh Rosen
Publisher : Springer Science & Business Media
Release : 2014-04-11
ISBN : 3319058797
Language : En, Es, Fr & De

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Book Description :

This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.

Endothelial Dysfunction and Inflammation

Endothelial Dysfunction and Inflammation Book
Author : Shauna Dauphinee,Aly Karsan
Publisher : Springer Science & Business Media
Release : 2010-09-24
ISBN : 3034601689
Language : En, Es, Fr & De

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Book Description :

Endothelial dysfunction is broadly defined as a disruption of the balance between vasoactive mediators and a propensity towards an inflammatory state. This volume provides an overview of the fields of endothelial dysfunction and inflammation through the discussion of topics ranging from the molecular biology of activated endothelial cells to the endothelium in inflammatory disease and therapeutic approaches targeting endothelial dysfunction. Topics include: Heterogeneity of the endothelium during inflammation, oxidative stress and endothelial dysfunction, biology and regulation of nitric oxide in inflammatory pathologies, endothelial dysfunction in inflammatory diseases, such as diabetes and atherosclerosis and Clinical methods used to assess endothelial function. This book brings together basic and clinical research to assist the reader in bridging connections from bench-to-bedside. Written by expert researchers in the fields of endothelial biology, inflammation research and clinical science, it serves as a useful reference for academic and industrial researchers, clinicians, and trainees in the medical profession.

Emerging Therapies Targeting the Pathophysiology of Sickle Cell Disease An Issue of Hematology Oncology Clinics

Emerging Therapies Targeting the Pathophysiology of Sickle Cell Disease  An Issue of Hematology Oncology Clinics  Book
Author : Elliot Vichinsky
Publisher : Elsevier Health Sciences
Release : 2014-05-23
ISBN : 0323290000
Language : En, Es, Fr & De

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Book Description :

This issue of Hematology/Oncology Clinics, guest edited by Dr. Elliott Vichinsky, is devoted to Sickle Cell Disease, and focuses on pathophysiology of hemoglobinopathies, therapeutic targets, and new approaches to correcting ineffective erythropoiesis and iron dysregulation. Articles in this issue include Polymerization and red cell membrane changes; Overview on reperfusion injury in the pathophysiology of SCD; Regulation of ineffective erythropoiesis in iron metabolism; Altering oxygen affinity; Cellular adhesion and the endothelium; Arginine therapy; Role of the hemostatic system on SCD pathophysiology and potential therapeutics; Adenosine signaling and novel therapies; New approaches to correcting ineffective erythropoiesis and iron dysregulation; New approaches to correcting ineffective erythropoiesis and iron dysregulation; Fetal hemoglobin induction; Gene therapy for hemoglobinopathies; and Oxidative injury and the role of antioxidant therapy.

Vascular Aging Facts and Factors

Vascular Aging  Facts and Factors Book
Author : Elisabet Vila,Francesc Jiménez-Altayó,Paula Dantas
Publisher : Frontiers E-books
Release :
ISBN : 2889190528
Language : En, Es, Fr & De

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Book Description :

The increasing mean age of the population in developed countries has turned out to be an economic and social problem. Cardiovascular disease has long been considered to be age related in terms of their onset and progression. As such, we can say that the increase in life expectancy goes in parallel with increased incidence of cardiovascular disease. With age, a number of changes occur in the vasculature altering the homeostasis of the irrigated organs promoting target organ damage. While different adaptive mechanisms to protect vessels against mild stress have been described, the aging process induces a progressive failure of protective mechanisms, leading to vascular changes and higher susceptibility to cardiovascular diseases. Indeed, vascular aging is exacerbated by coexisting cardiovascular risk factors, such as hypertension, metabolic syndrome and diabetes. Compelling evidence indicates that diminished endothelial relaxation and increase, decrease, or no change in contractile responses to several agonists is associated with aging. There is an increase of vasoconstrictor factors expression and a decrease of vasodilators. Morphologic changes include lumen diameter enlargement, wall thickening and alterations of matrix substances as increased collagen or decreased elastin deposition, ultimately leading to greater arterial stiffening (reduced compliance). Importantly, arterial stiffness is an independent predictor of cardiovascular morbidity and mortality. Cellular and molecular mechanisms have also been documented. Senescence at the cellular level involves alterations in Ca2+ signaling and down regulation of anti-aging proteins. Both endothelial and smooth muscle cells change their number, morphology, function and their regenerative ability. Aging is also associated with a gradual loss of antioxidant defense mechanisms, a proinflammatory shift in the cytokine expression profile and a production of reactive oxygen species such as superoxide (O2-) that promotes the breakdown of nitric oxide. Nitric oxide and O2- interact to form peroxynitrite known to nitrosylate proteins affecting their physiological function. However, vascular wall proteins may also suffer from other potentially deleterious modifications as glycation (Maillard reaction) and glyco-oxidative reactions with increasing age, which could be linked to the age-associated changes in vascular function. Various strategies have shown benefit in preventing, delaying or attenuating vascular aging. For instance, a healthy lifestyle including low fat diet and/or exercise have a favorable effect. Nevertheless, it yet remains to be fully demonstrated whether vascular aging can be pharmacologically prevented. This Research Topic is intended to bring together research efforts to understand the causes and consequences of vascular aging and propose new therapeutic strategies for the management of vascular senescence.

Endothelial Dysfunctions in Vascular Disease

Endothelial Dysfunctions in Vascular Disease Book
Author : Raffaele De Caterina,Peter Libby
Publisher : John Wiley & Sons
Release : 2008-04-15
ISBN : 0470994096
Language : En, Es, Fr & De

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Book Description :

Bridging the gap between the laboratory and the bedside, this timely volume illuminates the connection between endothelial dysfunction and vascular disease. This comprehensive survey of atherosclerotic disease begins with biology – incorporating the latest breakthroughs in the field – then elucidates risk factors and diagnostic tools and markers. A major section on endothelium-directed prevention and therapy shows you how to apply cutting-edge research to clinical care. Under the careful editorial guidance of Drs. De Caterina and Libby, the highly-regarded contributors address: endothelial activation and the initiation of atherosclerosis mechanisms of plaque progression and complications the role of LDL in the origin and progression of atherosclerosis advanced glycation endproducts and the accelerated atherosclerosis in diabetes oxidative stress and vascular disease soluble adhesion molecules as markers of vascular disease hormone-replacement therapy and cardiovascular risk anti-oxidants and endothelial protection and more. The first book dedicated to the central role of endothelial dysfunction in vascular disease, this concise volume gathers all the latest information on the subject into one convenient and cohesive text. Make sure your patients are benefiting from current knowledge by keeping a copy of Enothelial Dysfunctions in Vascular Disease close at hand for frequent consultation. Introduction Every book has a history, this one not excepted, having emerged from intersections in professional lives of the Editors. This book bears the fruits of a collaboration between the “pupil” (RDC) and the “mentor” (PL). During an extended sabbatical of the pupil in Boston in 1994, we probed together the concept that endothelial dysfunction served as a common denominator of vascular disease, with the balance between inflammation and its inhibition as a fulcrum of the regulation of the behavior of endothelial cells. As practicing cardiologists in our clinical lives, we sought to link to endothelial function the mechanisms of action of risk factors and of pharmacologic agents used to treat and prevent vascular disease. The pupil therefore authored a few reviews on the mechanism of action of risk factors and included them in a small book, published in Italian, for which the mentor wrote a preface. The book was greeted with favor from the Italian cardiological community, and provided the nidus for the present, more ambitious endeavor, which includes updated reviews on the pathogenesis of vascular disease and on the most novel aspects of vascular biology. This enterprise was enabled by the contributions of many of our former or present collaborators and colleagues, without whose enthusiasm and engagement this work could never have seen light. We largely underestimated the devotion necessary on our own side at the beginning, but it ultimately yielded a product that we feel achieves our original goals. We are aware that we confront a continuously evolving topic, where frequent updates would be desirable - if not necessary. Yet, we believe in the value of books - such as the current one - that attempt to organize in a snapshot of time, the vast amount of literature available in a coherent and comprehensive scheme. We are aware of existing gaps, of emerging material not paid its due, and of the rapid evolution of some of the concepts highlighted within. The links between the laboratory and the clinic have never afforded more opportunity for new understanding and advances in diagnosis and treatment than today We hope that our colleagues, vascular biologists cardiologists, internists, and other physicians alike will find this compendium a useful guide to this most exciting time in vascular biology and medicine —Raffaele De Caterina and Peter Libby