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Emerging Concepts In Ribosome Structure Biogenesis And Function

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Emerging Concepts in Ribosome Structure Biogenesis and Function

Emerging Concepts in Ribosome Structure  Biogenesis  and Function Book
Author : Vijay Kumar
Publisher : Academic Press
Release : 2021-09-25
ISBN : 0128167343
Language : En, Es, Fr & De

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Book Description :

Ribosome biogenesis is the process of making ribosomes which are responsible for mRNA translation into proteins. It is a tightly regulated process closely linked to nearly all biochemical and cellular processes, including cell division, growth, and development. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides a synthesized overview of all the parts engaged in this process. The book begins by providing an introduction to the ribosome factory, its origin, and its evolution of translation. It then goes on to describe ribosome structure including subunits, RNA, and protein components. Ribosome biogenesis and its emergence as a frontier research area for translational potential in cancer and other diseases are also discussed. In addition, the book explores current developments in ribosome research like the emergence of ribosomopathies, how deregulation of ribosome biogenesis can impact disease mechanisms and aging, and the discovery of specialized ribosomes that have specific functions that may translate differentially with consequences on normal and pathological processes. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides fundamental coverage and emerging research on ribosomes, biogenesis, and their structure and function and is a resourceful introduction for new researchers and those engaged in interdisciplinary ribosomal research. Provides an overview of ribosome biogenesis and examines its involvement in cell transformation and cancerous growth. Covers disorders related to the ribosome (ribosomopathies) and explains the significance of ribosome dysfunction in human diseases. Includes commonly used methods to study ribosomes, such as polysome preparation, RNA profiling and proteomics, CryoEM, and Cell-free assays along with proper illustrations.

Mitochondrial OXPHOS System Emerging Concepts and Technologies and Role in Disease

Mitochondrial OXPHOS System  Emerging Concepts and Technologies and Role in Disease Book
Author : David Pacheu-Grau,Erika Fernandez-Vizarra,Gloria Garrabou,Sylvie Callegari
Publisher : Frontiers Media SA
Release : 2022-06-06
ISBN : 2889763307
Language : En, Es, Fr & De

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Book Description :

Download Mitochondrial OXPHOS System Emerging Concepts and Technologies and Role in Disease book written by David Pacheu-Grau,Erika Fernandez-Vizarra,Gloria Garrabou,Sylvie Callegari, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Nucleolus

The Nucleolus Book
Author : Mark O. J. Olson
Publisher : Springer Science & Business Media
Release : 2011-09-15
ISBN : 1461405149
Language : En, Es, Fr & De

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Book Description :

Within the past two decades, extraordinary new functions for the nucleolus have begun to appear, giving the field a new vitality and generating renewed excitement and interest. These new discoveries include both newly-discovered functions and aspects of its conventional role. The Nucleolus is divided into three parts: nucleolar structure and organization, the role of the nucleolus in ribosome biogenesis, and novel functions of the nucleolus.

Molecular Biology of the Cell

Molecular Biology of the Cell Book
Author : Bruce Alberts
Publisher : Unknown
Release : 2004
ISBN : 9780815332183
Language : En, Es, Fr & De

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Book Description :

Download Molecular Biology of the Cell book written by Bruce Alberts, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

New Concepts of Antiviral Therapy

New Concepts of Antiviral Therapy Book
Author : Elke Bogner,Andreas Holzenburg
Publisher : Springer Science & Business Media
Release : 2007-01-31
ISBN : 0387310479
Language : En, Es, Fr & De

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Book Description :

Antiviral drugs are vital - but imperfect - tools for treatment and prevention of viral infections. Undesirable effects, from drug resistant viruses to low oral bioavailability, toxicity and severe side effects limit clinical usefulness. These factors drive demand for improved antiviral strategies. This book offers an up-to-date review of new drugs and targets, novel modes of action, vector-based treatments and even the blocking of defined genes by inhibiting mRNA formation (siRNA). Includes contributions by acknowledged experts; the book will serve as a compendium for R&D and educational professionals, and be of value for students.

Proteins of the Nucleolus

Proteins of the Nucleolus Book
Author : Danton H O'Day,Andrew Catalano
Publisher : Springer Science & Business Media
Release : 2013-02-26
ISBN : 9400758189
Language : En, Es, Fr & De

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Book Description :

This book contains 14 original review chapters each yielding new, exciting and intriguing data about the emerging understanding of nucleolar structure and function in normal, stressed and diseased cells. The goal of this work is to provide special insight into the nucleolus of the past, present and future, as well its regulation, translocation, and biomedical function. A multitude of topics are introduced and discussed in detail, including nucleologenesis, nucleolar architecture, nucleolar targeting, retention, anchoring, translocation, and the relationship between the nucleolus and cancer. This book also brings together work from several different species, from human to Drosophila to Dictyostelium and other eukaryotic microbes. The final chapter summarizes some of the issues brought up in the various chapters with a view to future research. This book supports the continued emergence of the nucleolus as a dynamic intranuclear region that oversees a vast diversity of events.

International Review of Cell and Molecular Biology

International Review of Cell and Molecular Biology Book
Author : Kwang W. Jeon
Publisher : Academic Press
Release : 2010-11-19
ISBN : 9780123812537
Language : En, Es, Fr & De

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Book Description :

International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Impact factor for 2008: 4.935. Authored by some of the foremost scientists in the field Provides up-to-date information and directions for future research Valuable reference material for advanced undergraduates, graduate students and professional scientists

The Biogenesis of Cellular Organelles

The Biogenesis of Cellular Organelles Book
Author : Chris Mullins
Publisher : Springer Science & Business Media
Release : 2007-03-06
ISBN : 0387268677
Language : En, Es, Fr & De

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Book Description :

The Biogenesis of Cellular Organelles represents a comprehensive summary of recent advances in the study of the biogenesis and functional dynamics of the major organelles operating in the eukaryotic cell. This book begins by placing the study of organelle biogenesis in a historical perspective by describing past scientific strategies, theories, and findings and relating these foundations to current investigations. Reviews of protein and lipid mediators important for organelle biogenesis are then presented, and are followed by summaries focused on the endoplasmic reticulum, Golgi, lysosome, nucleus, mitochondria, and peroxisome.

Encyclopedia of Cell Biology

Encyclopedia of Cell Biology Book
Author : Anonim
Publisher : Academic Press
Release : 2015-08-07
ISBN : 0123947960
Language : En, Es, Fr & De

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Book Description :

The Encyclopedia of Cell Biology offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences. Fully annotated color images and videos for full comprehension of concepts, with layered content for readers from different levels of experience Includes information on cytokinesis, cell biology, cell mechanics, cytoskeleton dynamics, stem cells, prokaryotic cell biology, RNA biology, aging, cell growth, cell Injury, and more In-depth linking to Academic Press/Elsevier content and additional links to outside websites and resources for further reading A one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences

Research Awards Index

Research Awards Index Book
Author : Anonim
Publisher : Unknown
Release : 1981
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Research Awards Index book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

RNA Based Regulation in Human Health and Disease

RNA Based Regulation in Human Health and Disease Book
Author : Anonim
Publisher : Academic Press
Release : 2020-08-19
ISBN : 0128171944
Language : En, Es, Fr & De

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Book Description :

RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field

Regulation of Alternative Splicing

Regulation of Alternative Splicing Book
Author : Philippe Jeanteur
Publisher : Springer Science & Business Media
Release : 2013-03-14
ISBN : 3662097281
Language : En, Es, Fr & De

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Book Description :

The discovery in 1977 that genes are split into exons and introns has done away with the one gene - one protein dogma. Indeed, the removal of introns from the primary RNA transcript is not necessarily straightforward since there may be optional pathways leading to different messenger RNAs and consequently to different proteins. Examples of such an alternative splicing mechanism cover all fields of biology. Moreover, there are plenty of occurrences where deviant splicing can have pathological effects. Despite the high number of specific cases of alternative splicing, it was not until recently that the generality and extent of this phenomenon was fully appreciated. A superficial reading of the preliminary sequence of the human genome published in 2001 led to the surprising, and even deceiving to many scientists, low number of genes (around 32,000) which contrasted with the much higher figure around 150,000 which was previously envisioned. Attempts to make a global assessment of the use of alternative splicing are recent and rely essentially on the comparison of genomic mRNA and EST sequences as reviewed by Thanaraj and Stamm in the first chapter of this volume. Most recent estimates suggest that 40-60% of human genes might be alternatively spliced, as opposed to about 22% for C. elegans.

Ribosomes Structure Function and Dynamics

Ribosomes Structure  Function  and Dynamics Book
Author : Marina V. Rodnina,Wolfgang Wintermeyer,Rachel Green
Publisher : Springer Science & Business Media
Release : 2011-12-10
ISBN : 3709102154
Language : En, Es, Fr & De

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Book Description :

The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.

Current Catalog

Current Catalog Book
Author : National Library of Medicine (U.S.)
Publisher : Unknown
Release : 2022-10-07
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

First multi-year cumulation covers six years: 1965-70.

Law Enforcement in the United States

Law Enforcement in the United States Book
Author : James A. Conser,Gregory D. Russell,Terry E. Gingerich,Rebecca Paynich
Publisher : Jones & Bartlett Learning
Release : 2005
ISBN : 9780763783525
Language : En, Es, Fr & De

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Book Description :

Law Enforcement in the United States, Second Edition presents a unique balance of theory, history, and practice of American law enforcement. It provides readers with updated, important information ranging from the evolution and theory of social control to the training, function, and strategies involved in modern policing. The authors also examine the gray areas of law enforcement, ethics, forces in society that impact policing, and the laws governing police behavior.

BIOS Instant Notes in Molecular Biology

BIOS Instant Notes in Molecular Biology Book
Author : Alexander McLennan,Andy Bates,Phil Turner,Michael White
Publisher : Taylor & Francis
Release : 2012-11-27
ISBN : 1136160418
Language : En, Es, Fr & De

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Book Description :

Instant Notes in Molecular Biology, Fourth Edition is the perfect text for undergraduates looking for a concise introduction to the subject, or a study guide to use before examinations. Each topic begins with a summary of essential facts−an ideal revision checklist−followed by a description of the subject that focuses on core information, with clear, simple diagrams that are easy for students to understand and recall in essays and exams.

Control of Messenger RNA Stability

Control of Messenger RNA Stability Book
Author : Joel G. Belasco,George Brawerman
Publisher : Elsevier
Release : 2012-12-02
ISBN : 008091652X
Language : En, Es, Fr & De

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Book Description :

This is the first comprehensive review of mRNA stability and its implications for regulation of gene expression. Written by experts in the field, Control of Messenger RNA Stability serves both as a reference for specialists in regulation of mRNA stability and as a general introduction for a broader community of scientists. Provides perspectives from both prokaryotic and eukaryotic systems Offers a timely, comprehensive review of mRNA degradation, its regulation, and its significance in the control of gene expression Discusses the mechanisms, RNA structural determinants, and cellular factors that control mRNA degradation Evaluates experimental procedures for studying mRNA degradation

RNA Helicases

RNA Helicases Book
Author : Anonim
Publisher : Academic Press
Release : 2012-11-13
ISBN : 0123972299
Language : En, Es, Fr & De

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Book Description :

This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases. The contributions in this volume cover the broad scope of methods in the research on these enzymes. Several chapters describe quantitative biophysical and biochemical approaches to study molecular mechanisms and conformational changes of RNA helicases. Further chapters cover structural analysis, examination of co-factor effects on several representative examples, and the analysis of cellular functions of select enzymes. Two chapters outline approaches to the analysis of inhibitors that target RNA helicases. This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases The contributions in this volume cover the broad scope of methods in the research on these enzymes

Freeze Fracture Images of Cells and Tissues

Freeze Fracture Images of Cells and Tissues Book
Author : Richard L. Roberts,Richard G. Kessel,Hai-Nan Tung
Publisher : Oxford University Press, USA
Release : 1991
ISBN : 9780195052282
Language : En, Es, Fr & De

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Book Description :

Freeze Fracture Images of Cells and Tissues presents a complete and up-to-date account of the macromolecular organization of membranes and the many membrane specializations of cells as well as overall cellular organizations as reflected in tissues and organs. While the book emphasizes freeze fracture images and the useful scientific information contained in these images (most of the images illustrated were prepared specifically for this book), the authors have liberally included transmission electron micrographs of ultrathin sectioned cells, tissues and organs in order to aid in the interpretation of the freeze fracture image and increase the book's utility. Where three dimensional views are particularly useful, scanning electron micrographs are included. Freeze Fracture Images of Cells and Tissues provides a complete and correlative treatment of biological organization at the cellular and macromolecular levels.