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Electrophysiology Measurements For Studying Neural Interfaces

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Electrophysiology Measurements for Studying Neural Interfaces

Electrophysiology Measurements for Studying Neural Interfaces Book
Author : Mohammad M. Aria
Publisher : Academic Press
Release : 2020-05-15
ISBN : 0128170719
Language : En, Es, Fr & De

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Book Description :

Electrophysiology Measurements for Studying Neural Interfaces helps readers to choose a proper cell line and set-up for studying different bio-electronic interfaces before delving into the electrophysiology techniques available. Therefore, this book details the materials and devices needed for different types of neural stimulation such as photoelectrical and photothermal stimulations. Also, modern techniques like optical electrophysiology and calcium imaging in this book provides readers with more available approaches to monitor neural activities in addition to whole-cell patch-clamp technology. Details steps of an electrophysiology project from start to finish for graduate students employing the technique in their research Includes sample electrophysiological studies with multiple cell lines (PC12, N2a, NG108, SHSY, and embryonic stem cell lines) to facilitate research Features data analysis of electrophysiology results from various relevant experiments and cell culture tips

Closing the Loop Around Neural Systems

Closing the Loop Around Neural Systems Book
Author : Steve M Potter,Eberhard E Fetz,Ahmed El Hady
Publisher : Frontiers Media SA
Release : 2014-12-03
ISBN : 288919356X
Language : En, Es, Fr & De

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Book Description :

Closed-loop neurophysiology has been accelerated by recent software and hardware developments and by the emergence of novel tools to control neuronal activity with spatial and temporal precision, in which stimuli are delivered in real time based on recordings or behavior. Real-time stimulation feedback enables a wide range of innovative studies of information processing and plasticity in neuronal networks. This Research Topic e-Book comprises 16 Original Research Articles, seven Methods Articles, and seven Reviews, Mini- Reviews, and Perspectives, all peer-reviewed and published in Frontiers in Neural Circuits. The contributions deal with closed loop neurophysiology experiments at a variety of levels of neural circuit complexity. Some include modeling and theoretical analyses. New enabling technologies and techniques are described. Novel work is presented from experiments in vitro, in vivo, and in humans, along with their clinical and technological implications for improving the human condition.

Neural Interface Engineering for Electrophysiology Application

Neural Interface Engineering for Electrophysiology Application Book
Author : Hyungsoo Kim
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The brain is a wondrous and complex organ, a biological machine forged by the evolutionary forces of nature. The human brain contains 100 billion neurons and each neuron is connected by synapses to several thousand other neurons. Connected neurons work together to produce perceptions and sensations, memories and emotions, physical movements and abstract constructs. The neurons communicate by means of electricity that passes along and across their cellular membrane. Much of what is known about brain physiology is through the measurement of this electrical activity, either with relatively large electrodes placed on the scalp or tiny microelectrodes inserted into the brain tissue itself. At the finer end of this scale, scientists have discovered much about the way individual neurons extract sensory information, adapt their behavior to form a memory, and convey signals to other regions of the brain. However, it has long been recognized that the brain operates on a global scale, through the collective behavior and interaction of its neural units1. Information is processed in several regions of the brain simultaneously, and the activity of neighboring neurons can be quite different from one another. By one analogy, the attempt to assess brain function by observing a single neuron is like looking at the output of one transistor to learn how a computer works. Thus, the recording of many neurons simultaneously is necessary to truly reveal the mechanisms of the brain2. In recent decades, a variety of recording techniques have been developed for a neural interface such as electroencephalography (EEG), magneto-encephalography (MEG), electrocorticography (ECOG), local field potential (LFP) recordings, micro-electrode array (MEA) and peripheral nerve interfaces (PNIs) to the micron-level precision required for multi-neuron recording. Their small size allows many recording channels to be placed onto one device. One of the goals of neural interface research is to create a seamless connection between the nervous system and the neuroprostheses either by stimulating or by recording from neural tissue to restore or substitute function for individuals with neurological deficits or disabilities. Hence, significant amount of scientific and technological efforts have been devoted to develop neural interfaces that link the nervous system with robotic prosthetic devices. The creation of a novel neural interface is essential for developing the full potential of advanced prosthesis technology required to replace lost limbs. Additionally, meticulous studies of a single neuron and between neurons utilizing the neural interface technology should be made to elucidate fundamental biological phenomena such as cellular processes and heterogeneities. Particularly, an electrophysiological study of neural networks can provide knowledge to unravel the functions of brain. When fundamental research about molecular and cellular mechanisms of a single neuron and electrophysiological studies using neural interfaces on both the central and peripheral nervous systems are done together, it has a synergistic effect on neural interface technology. The research and methodologies described in this dissertation stem from our research group's efforts to optimize the design and expand the applications of neural interfaces. The dissertation is organized into four chapters. Chapter 1 is a review of neural interface technology and study of neural signal detection. This chapter provides a foundation for Chapter 2 and 3. Chapter 2 is a study of a neural interface as cellular level research. We present an advanced single-neuronal cell culture and monitoring platform using a fully transparent microfluidic dielectrophoresis (DEP) device for unabated monitoring of neuronal cell development and function. The device is mounted inside a sealed incubation chamber to ensure improved homeostatic conditions and reduced contamination risk. Consequently, we successfully trap and culture single neurons on a desired location and monitor their growth process over a week. Chapter 3 deals with the specific application of PNIs to the sciatic nerve of a rat as a nervous system-level research. We developed novel devices, "cuff and sieve electrodes" (CASE), that integrate microfabricated cuff and sieve electrodes capable of broad (via cuff) and precise (via sieve) selectivity to increase the strengths and simultaneously decrease the weaknesses of traditional electrode designs. We performed terminal device implantations in a rat sciatic transection and repair model to test the capacity of the CASE interface. The sciatic nerve was stimulated by the sieve portion of the CASE electrode and somatosensory evoked potentials were recorded from the somatosensory cortex via micro-eletrocorticography. The ability to elicit cortical responses from sciatic nerve stimulation demonstrates the proof of concept for both the implantation and chronic monitoring of CASE interfaces for innovative prosthetic control. Lastly, in Chapter 4, I will identify areas in which further investigation is needed and propose future directions of both cellular and system-level neural interface.

Bridging the Gap in Neuroelectronic Interfaces

Bridging the Gap in Neuroelectronic Interfaces Book
Author : Jeffrey R. Capadona,Ulrich G. Hofmann
Publisher : Frontiers Media SA
Release : 2020-07-09
ISBN : 2889638502
Language : En, Es, Fr & De

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Book Description :

Download Bridging the Gap in Neuroelectronic Interfaces book written by Jeffrey R. Capadona,Ulrich G. Hofmann, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neural Engineering

Neural Engineering Book
Author : Bin He
Publisher : Springer Nature
Release : 2020-09-21
ISBN : 3030433951
Language : En, Es, Fr & De

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Book Description :

This third edition overviews the essential contemporary topics of neuroengineering, from basic principles to the state-of-the-art, and is written by leading scholars in the field. The book covers neural bioelectrical measurements and sensors, EEG signal processing, brain-computer interfaces, implantable and transcranial neuromodulation, peripheral neural interfacing, neuroimaging, neural modelling, neural circuits and system identification, retinal bioengineering and prosthetics, and neural tissue engineering. Each chapter is followed by homework questions intended for classroom use. This is an ideal textbook for students at the graduate and advanced undergraduate level as well as academics, biomedical engineers, neuroscientists, neurophysiologists, and industry professionals seeking to learn the latest developments in this emerging field. Advance Praise for Neural Engineering, 3rd Edition: “A comprehensive and timely contribution to the ever growing field of neural engineering. Bin He’s edited volume provides chapters that cover both the fundamentals and state-of-the-art developments by the world’s leading neural engineers." Dr. Paul Sajda, Department of Biomedical Engineering, Electrical Engineering and Radiology, Columbia University “Neural Engineering, edited by Prof. He, is an outstanding book for students entering into this fast evolving field as well as experienced researchers. Its didactic and comprehensive style, with each chapter authored by leading scientific authorities, provides the ultimate reference for the field.” Dr. Dario Farina, Department of Bioengineering, Imperial College London, London, UK "Neural Engineering has come of age. Major advances have made possible prosthesis for the blind, mind control for quadraplegics and direct intervention to control seizures in epilepsy patients. Neural Engineering brings together reviews by leading researchers in this flourishing field. Dr. Terrence Sejnowski, Salk Institute for Biolgical Studies and UC San Diego

Neural Interface Engineering

Neural Interface Engineering Book
Author : Liang Guo
Publisher : Springer Nature
Release : 2020-05-04
ISBN : 3030418545
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive reference to major neural interfacing technologies used to transmit signals between the physical world and the nervous system for repairing, restoring and even augmenting body functions. The authors discuss the classic approaches for neural interfacing, the major challenges encountered, and recent, emerging techniques to mitigate these challenges for better chronic performances. Readers will benefit from this book’s unprecedented scope and depth of coverage on the technology of neural interfaces, the most critical component in any type of neural prostheses. Provides comprehensive coverage of major neural interfacing technologies; Reviews and discusses both classic and latest, emerging topics; Includes classification of technologies to provide an easy grasp of research and trends in the field.

Handbook of Artificial Intelligence for Music

Handbook of Artificial Intelligence for Music Book
Author : Eduardo Reck Miranda
Publisher : Springer Nature
Release : 2021-07-02
ISBN : 3030721167
Language : En, Es, Fr & De

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Book Description :

This book presents comprehensive coverage of the latest advances in research into enabling machines to listen to and compose new music. It includes chapters introducing what we know about human musical intelligence and on how this knowledge can be simulated with AI. The development of interactive musical robots and emerging new approaches to AI-based musical creativity are also introduced, including brain–computer music interfaces, bio-processors and quantum computing. Artificial Intelligence (AI) technology permeates the music industry, from management systems for recording studios to recommendation systems for online commercialization of music through the Internet. Yet whereas AI for online music distribution is well advanced, this book focuses on a largely unexplored application: AI for creating the actual musical content.

The Routledge Research Companion to Electronic Music Reaching out with Technology

The Routledge Research Companion to Electronic Music  Reaching out with Technology Book
Author : Simon Emmerson
Publisher : Routledge
Release : 2018-05-16
ISBN : 131704360X
Language : En, Es, Fr & De

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Book Description :

The theme of this Research Companion is 'connectivity and the global reach of electroacoustic music and sonic arts made with technology'. The possible scope of such a companion in the field of electronic music has changed radically over the last 30 years. The definitions of the field itself are now broader - there is no clear boundary between 'electronic music' and 'sound art'. Also, what was previously an apparently simple divide between 'art' and 'popular' practices is now not easy or helpful to make, and there is a rich cluster of streams of practice with many histories, including world music traditions. This leads in turn to a steady undermining of a primarily Euro-American enterprise in the second half of the twentieth century. Telecommunications technology, most importantly the development of the internet in the final years of the century, has made materials, practices and experiences ubiquitous and apparently universally available - though some contributions to this volume reassert the influence and importance of local cultural practice. Research in this field is now increasingly multi-disciplinary. Technological developments are embedded in practices which may be musical, social, individual and collective. The contributors to this companion embrace technological, scientific, aesthetic, historical and social approaches and a host of hybrids – but, most importantly, they try to show how these join up. Thus the intention has been to allow a wide variety of new practices to have voice – unified through ideas of 'reaching out' and 'connecting together' – and in effect showing that there is emerging a different kind of 'global music'.

Brain Computer Interfaces for Perception Learning and Motor Control

Brain Computer Interfaces for Perception  Learning  and Motor Control Book
Author : Saugat Bhattacharyya,Amit Konar,Haider Raza,Anwesha Khasnobish
Publisher : Frontiers Media SA
Release : 2021-12-21
ISBN : 2889718514
Language : En, Es, Fr & De

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Book Description :

Download Brain Computer Interfaces for Perception Learning and Motor Control book written by Saugat Bhattacharyya,Amit Konar,Haider Raza,Anwesha Khasnobish, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Spatiotemporal Neural Interface Dynamics Elucidated with Multi Channel Electrochemistry

Spatiotemporal Neural Interface Dynamics Elucidated with Multi Channel Electrochemistry Book
Author : Matthew Douglas Johnson
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Spatiotemporal Neural Interface Dynamics Elucidated with Multi Channel Electrochemistry book written by Matthew Douglas Johnson, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Guide to Research Techniques in Neuroscience

Guide to Research Techniques in Neuroscience Book
Author : Matt Carter,Rachel Essner,Nitsan Goldstein,Manasi Iyer
Publisher : Academic Press
Release : 2022-04-08
ISBN : 0323915612
Language : En, Es, Fr & De

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Book Description :

Modern neuroscience research is inherently multidisciplinary, with a wide variety of cutting edge new techniques to explore multiple levels of investigation. This Third Edition of Guide to Research Techniques in Neuroscience provides a comprehensive overview of classical and cutting edge methods including their utility, limitations, and how data are presented in the literature. This book can be used as an introduction to neuroscience techniques for anyone new to the field or as a reference for any neuroscientist while reading papers or attending talks. • Nearly 200 updated full-color illustrations to clearly convey the theory and practice of neuroscience methods • Expands on techniques from previous editions and covers many new techniques including in vivo calcium imaging, fiber photometry, RNA-Seq, brain spheroids, CRISPR-Cas9 genome editing, and more • Clear, straightforward explanations of each technique for anyone new to the field • A broad scope of methods, from noninvasive brain imaging in human subjects, to electrophysiology in animal models, to recombinant DNA technology in test tubes, to transfection of neurons in cell culture • Detailed recommendations on where to find protocols and other resources for specific techniques • “Walk-through boxes that guide readers through experiments step-by-step

Nanotechnology and Neuroscience Nano electronic Photonic and Mechanical Neuronal Interfacing

Nanotechnology and Neuroscience  Nano electronic  Photonic and Mechanical Neuronal Interfacing Book
Author : Massimo De Vittorio,Luigi Martiradonna,John Assad
Publisher : Springer
Release : 2014-07-08
ISBN : 1489980385
Language : En, Es, Fr & De

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Book Description :

This book describes the use of modern micro- and nanofabrication technologies to develop improved tools for stimulating and recording electrical activity in neuronal networks. It provides an overview of the different ways in which the “nano-world” can be beneficial for neuroscientists, including improvement of mechanical adhesion of cells on electrodes, tight-sealed extracellular recordings or intracellular approaches with strongly reduced invasiveness and tools for localized electrical or optical stimulation in optogenetics experiments. Specific discussion of fabrication strategies is included, to provide a comprehensive guide to develop micro and nanostructured tools for biological applications. A perspective on integrating these devices with state-of-the-art technologies for large-scale in vitro and in vivo experiments completes the picture of neuronal interfacing with micro- and nanostructures.

Brain Computer Interfaces

Brain Computer Interfaces Book
Author : Jonathan Wolpaw,Elizabeth Winter Wolpaw
Publisher : OUP USA
Release : 2012-01-24
ISBN : 0195388852
Language : En, Es, Fr & De

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Book Description :

In the last 15 years, a recognizable surge in the field of Brain Computer Interface (BCI) research and development has emerged. This emergence has sprung from a variety of factors. For one, inexpensive computer hardware and software is now available and can support the complex high-speed analyses of brain activity that is essential is BCI. Another factor is the greater understanding of the central nervous system including the abundance of new information on the nature and functional correlates of brain signals and improved methods for recording these signals in both the short-term and long-term. And the third, and perhaps most significant factor, is the new recognition of the needs and abilities of people disabled by disorders such as cerebral palsy, spinal cord injury, stroke, amyotrophic lateral sclerosis (ALS), multiple sclerosis, and muscular dystrophies. The severely disabled are now able to live for many years and even those with severely limited voluntary muscle control can now be given the most basic means of communication and control because of the recent advances in the technology, research, and applications of BCI. This book is intended to provide an introduction to and summary of essentially all major aspects of BCI research and development. Its goal is to be a comprehensive, balanced, and coordinated presentation of the field's key principles, current practice, and future prospects.

Neural Prostheses for Locomotion

Neural Prostheses for Locomotion Book
Author : Daniel P. Ferris,Mikhail Lebedev,Yury Ivanenko,Kyuhwa Lee,Yoshio Sakurai,Irina N. Beloozerova
Publisher : Frontiers Media SA
Release : 2022-01-04
ISBN : 2889719391
Language : En, Es, Fr & De

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Book Description :

Download Neural Prostheses for Locomotion book written by Daniel P. Ferris,Mikhail Lebedev,Yury Ivanenko,Kyuhwa Lee,Yoshio Sakurai,Irina N. Beloozerova, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Research Awards Index

Research Awards Index Book
Author : Anonim
Publisher : Unknown
Release : 1985
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Research Awards Index book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Handbook of Neural Activity Measurement

Handbook of Neural Activity Measurement Book
Author : Romain Brette,Alain Destexhe
Publisher : Cambridge University Press
Release : 2012-09-06
ISBN : 0521516226
Language : En, Es, Fr & De

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Book Description :

Underlying principles of the various techniques are explained, enabling neuroscientists to extract meaningful information from their measurements.

Future Trends in Microelectronics

Future Trends in Microelectronics Book
Author : Serge Luryi,Jimmy Xu,Alexander Zaslavsky
Publisher : John Wiley & Sons
Release : 2013-06-13
ISBN : 1118678184
Language : En, Es, Fr & De

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Book Description :

Leaders in the field predict the future of themicroelectronics industry This seventh volume of Future Trends in Microelectronicssummarizes and synthesizes the latest high-level scientificdiscussions to emerge from the Future Trends in Microelectronicsinternational workshop, which has occurred every three years since1995. It covers the full scope of cutting-edge topics inmicroelectronics, from new physical principles (quantum computing,correlated electrons), to new materials (piezoelectricnanostructures, terahertz plasmas), to emerging device technologies(embedded magnetic memories, spin lasers, and biocompatiblemicroelectronics). An ideal book for microelectronics professionals and studentsalike, this volume of Future Trends in Microelectronics: Identifies the direction in which microelectronics is headed,enabling readers to move forward with research in an informed,efficient, and profitable manner Includes twenty-nine contributor chapters by internationalauthorities from leading universities, major semiconductorcompanies, and government laboratories Provides a unified, cohesive exploration of various trends inmicroelectronics, looking to future opportunities, rather than pastsuccesses

Development of Amorphous Silicon Carbide Ultramicroelectrode Arrays for Neural Stimulation and Recording

Development of Amorphous Silicon Carbide Ultramicroelectrode Arrays for Neural Stimulation and Recording Book
Author : Felix Deku
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Interest in restoring lost function using neuro-prosthetic devices and treating neurological disorders or neurodegenerative diseases through electrical stimulation of neural activity has increased in recent years. For example, implantable cortical neural interfaces allow investigation of sensorimotor learning, and control of both natural and prosthetic limbs through recording of volitional intent and stimulation of neural activity. However, these interfaces decline rapidly in performance over chronic timescales. Foreign body response is believed to limit their recording and stimulation reliability. The resulting glial scar isolates the indwelling microelectrodes from healthy neuronal cells. The consequence is recording from large populations of weak neural signals and the requirement for high current amplitudes to deliver the necessary charge for neural activation. Recently, carbon fiber microelectrodes with small cross-sectional dimensions (below 10 μm) have been shown to reduce insertion damage to neurons and microvasculature, minimize adverse tissue reaction, and provide stable neural recording over chronic timescales. Despite these achievements, the development of carbon fiber MEAs faces the issue of micro-assembly, micromanipulation, and the general lack of control of the geometric surface area (GSA) of the active sites. This dissertation addresses these issues by developing ultrathin cellular or sub-cellular scale microelectrode arrays (MEAs) based on amorphous silicon carbide. Amorphous silicon carbide (a-SiC) deposited by plasma enhanced chemical vapor deposition has similar mechanical properties to carbon fiber but is amenable to thin-film microfabrication methods, thus permitting a wide variety of designs, control of GSA, and batch fabrication of microelectrode arrays. Challenges associated with residual stress control in the a-SiC and those associated with metal patterning needs to be addressed to use the a-SiC in ultrathin MEA designs. Also, implantation strategies for ultrathin MEA shanks and the burden of using small contact sites for electrochemical measurement, electrical stimulation and electrophysiology need to be addressed. In this dissertation, microelectrode arrays based on a-SiC were fabricated, characterized for their electrochemical properties in a saline model of the interstitial fluid, and evaluated functionally in songbird and rat brain. We describe stress engineering in the multilayered structure to regulate the curvature of the a-SiC MEAs. Engineering challenges associated with process controls to produce penetrating probes of reduced cross-sectional shank dimensions are discussed. We have developed implantation strategies to insert ultrathin a-SiC MEAs into rat motor cortex. We show that a minimum a-SiC thickness of 6 μm is required to insert 2 mm long a-SiC MEAs shanks into rat cortex without the need for insertion guides or temporary support structures. Below this thickness, we demonstrate that a-SiC MEAs will require temporary support structures such as polyethylene glycol or in situ designs that increases the critical buckling load of the implanted shanks. With the reduced shank dimensions, the electrode sites on the a-SiC MEA are small with high electrode impedance and low charge injection properties. We investigated low impedance coatings such as titanium nitride, sputtered iridium oxide and electrodeposited iridium oxide films as a means of improving the electrochemical performance for neural stimulation and recording. We show that cathodal charge injection capacities greater than 17 mC/cm2 can be achieved with the coated ultramicroelectrode site with appropriate biasing.

Emerging Technologies and Systems for Biologically Plausible Implementations of Neural Functions

Emerging Technologies and Systems for Biologically Plausible Implementations of Neural Functions Book
Author : Erika Covi,Elisa Donati,Stefano Brivio,Hadi Heidari
Publisher : Frontiers Media SA
Release : 2022-04-26
ISBN : 2889760006
Language : En, Es, Fr & De

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Book Description :

Download Emerging Technologies and Systems for Biologically Plausible Implementations of Neural Functions book written by Erika Covi,Elisa Donati,Stefano Brivio,Hadi Heidari, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cognitive Phase Transitions in the Cerebral Cortex Enhancing the Neuron Doctrine by Modeling Neural Fields

Cognitive Phase Transitions in the Cerebral Cortex   Enhancing the Neuron Doctrine by Modeling Neural Fields Book
Author : Robert Kozma,Walter J. Freeman
Publisher : Springer
Release : 2015-10-30
ISBN : 331924406X
Language : En, Es, Fr & De

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Book Description :

This intriguing book was born out of the many discussions the authors had in the past 10 years about the role of scale-free structure and dynamics in producing intelligent behavior in brains. The microscopic dynamics of neural networks is well described by the prevailing paradigm based in a narrow interpretation of the neuron doctrine. This book broadens the doctrine by incorporating the dynamics of neural fields, as first revealed by modeling with differential equations (K-sets). The book broadens that approach by application of random graph theory (neuropercolation). The book concludes with diverse commentaries that exemplify the wide range of mathematical/conceptual approaches to neural fields. This book is intended for researchers, postdocs, and graduate students, who see the limitations of network theory and seek a beachhead from which to embark on mesoscopic and macroscopic neurodynamics.