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Electrophysiology Measurements For Studying Neural Interfaces

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Electrophysiology Measurements for Studying Neural Interfaces

Electrophysiology Measurements for Studying Neural Interfaces Book
Author : Mohammad M. Aria
Publisher : Academic Press
Release : 2020-05-15
ISBN : 0128170719
Language : En, Es, Fr & De

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Book Description :

Electrophysiology Measurements for Studying Neural Interfaces helps readers to choose a proper cell line and set-up for studying different bio-electronic interfaces before delving into the electrophysiology techniques available. Therefore, this book details the materials and devices needed for different types of neural stimulation such as photoelectrical and photothermal stimulations. Also, modern techniques like optical electrophysiology and calcium imaging in this book provides readers with more available approaches to monitor neural activities in addition to whole-cell patch-clamp technology. Details steps of an electrophysiology project from start to finish for graduate students employing the technique in their research Includes sample electrophysiological studies with multiple cell lines (PC12, N2a, NG108, SHSY, and embryonic stem cell lines) to facilitate research Features data analysis of electrophysiology results from various relevant experiments and cell culture tips

Neural Interface Engineering for Electrophysiology Application

Neural Interface Engineering for Electrophysiology Application Book
Author : Hyungsoo Kim
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The brain is a wondrous and complex organ, a biological machine forged by the evolutionary forces of nature. The human brain contains 100 billion neurons and each neuron is connected by synapses to several thousand other neurons. Connected neurons work together to produce perceptions and sensations, memories and emotions, physical movements and abstract constructs. The neurons communicate by means of electricity that passes along and across their cellular membrane. Much of what is known about brain physiology is through the measurement of this electrical activity, either with relatively large electrodes placed on the scalp or tiny microelectrodes inserted into the brain tissue itself. At the finer end of this scale, scientists have discovered much about the way individual neurons extract sensory information, adapt their behavior to form a memory, and convey signals to other regions of the brain. However, it has long been recognized that the brain operates on a global scale, through the collective behavior and interaction of its neural units1. Information is processed in several regions of the brain simultaneously, and the activity of neighboring neurons can be quite different from one another. By one analogy, the attempt to assess brain function by observing a single neuron is like looking at the output of one transistor to learn how a computer works. Thus, the recording of many neurons simultaneously is necessary to truly reveal the mechanisms of the brain2. In recent decades, a variety of recording techniques have been developed for a neural interface such as electroencephalography (EEG), magneto-encephalography (MEG), electrocorticography (ECOG), local field potential (LFP) recordings, micro-electrode array (MEA) and peripheral nerve interfaces (PNIs) to the micron-level precision required for multi-neuron recording. Their small size allows many recording channels to be placed onto one device. One of the goals of neural interface research is to create a seamless connection between the nervous system and the neuroprostheses either by stimulating or by recording from neural tissue to restore or substitute function for individuals with neurological deficits or disabilities. Hence, significant amount of scientific and technological efforts have been devoted to develop neural interfaces that link the nervous system with robotic prosthetic devices. The creation of a novel neural interface is essential for developing the full potential of advanced prosthesis technology required to replace lost limbs. Additionally, meticulous studies of a single neuron and between neurons utilizing the neural interface technology should be made to elucidate fundamental biological phenomena such as cellular processes and heterogeneities. Particularly, an electrophysiological study of neural networks can provide knowledge to unravel the functions of brain. When fundamental research about molecular and cellular mechanisms of a single neuron and electrophysiological studies using neural interfaces on both the central and peripheral nervous systems are done together, it has a synergistic effect on neural interface technology. The research and methodologies described in this dissertation stem from our research group's efforts to optimize the design and expand the applications of neural interfaces. The dissertation is organized into four chapters. Chapter 1 is a review of neural interface technology and study of neural signal detection. This chapter provides a foundation for Chapter 2 and 3. Chapter 2 is a study of a neural interface as cellular level research. We present an advanced single-neuronal cell culture and monitoring platform using a fully transparent microfluidic dielectrophoresis (DEP) device for unabated monitoring of neuronal cell development and function. The device is mounted inside a sealed incubation chamber to ensure improved homeostatic conditions and reduced contamination risk. Consequently, we successfully trap and culture single neurons on a desired location and monitor their growth process over a week. Chapter 3 deals with the specific application of PNIs to the sciatic nerve of a rat as a nervous system-level research. We developed novel devices, "cuff and sieve electrodes" (CASE), that integrate microfabricated cuff and sieve electrodes capable of broad (via cuff) and precise (via sieve) selectivity to increase the strengths and simultaneously decrease the weaknesses of traditional electrode designs. We performed terminal device implantations in a rat sciatic transection and repair model to test the capacity of the CASE interface. The sciatic nerve was stimulated by the sieve portion of the CASE electrode and somatosensory evoked potentials were recorded from the somatosensory cortex via micro-eletrocorticography. The ability to elicit cortical responses from sciatic nerve stimulation demonstrates the proof of concept for both the implantation and chronic monitoring of CASE interfaces for innovative prosthetic control. Lastly, in Chapter 4, I will identify areas in which further investigation is needed and propose future directions of both cellular and system-level neural interface.

Issues in Biomedical Engineering Research and Application 2011 Edition

Issues in Biomedical Engineering Research and Application  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464964556
Language : En, Es, Fr & De

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Book Description :

Issues in Biomedical Engineering Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biomedical Engineering Research and Application. The editors have built Issues in Biomedical Engineering Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biomedical Engineering Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biomedical Engineering Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

A Report for the Year on the Research and Other Activities of the Division of Biology

A Report for the Year     on the Research and Other Activities of the Division of Biology Book
Author : California Institute of Technology. Division of Biology
Publisher : Unknown
Release : 1991
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download A Report for the Year on the Research and Other Activities of the Division of Biology book written by California Institute of Technology. Division of Biology, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Engineering the Interface Between Lipid Bilayers and Inorganic Materials

Engineering the Interface Between Lipid Bilayers and Inorganic Materials Book
Author : Anonim
Publisher : Stanford University
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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process, a unique methodology to compute the energetics of processes involving the interaction of nanostructured materials with soft matter structures was developed. In addition to these simulations, a physical model of cell deformation was developed to understand the mechanics of cell-device interaction. This was built on principles of continuum mechanics under a few simplifying assumptions. In addition to bringing down the parameter space for device design, this model explained a previously observed non-linear to linear transition in thin shell deformation experiments. Nanoscale `stealth' probed based on biomimetic design principles were fabricated using sophisticated microfabrication techniques. The electrical properties of the device were determined by performing cyclic voltammetry in a buffer solution with electrochemically active species. The formation of a well controlled junction between the post electrode and cell membrane was demonstrated by testing the device with red blood cells. A giga-ohm seal was observed to form spontaneously as the cell was brought close to the post, confirming intracellular access. The formation of giga-ohm seal is critical for patchclamping, a technique used extensively in the pharmaceutical industry. Together, MD simulations and cell deformation model provide a powerful approach to modify the device design depending upon the specific application. When coupled with the sophisticated yet flexible fabrication scheme developed for the device, the next generation of massively parallel and highly efficient interface between cells and electronics can be developed.

Acta oto rhino laryngologica Belgica

Acta oto rhino laryngologica Belgica Book
Author : Anonim
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Philosophical Transactions of the Royal Society of London

Philosophical Transactions of the Royal Society of London Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Practical Electrophysiological Methods

Practical Electrophysiological Methods Book
Author : Helmut Kettenmann,Rosemarie Grantyn
Publisher : Wiley-Liss
Release : 1992-11-11
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Designed to enable newcomers to electrophysiology to choose appropriate preparations and techniques for in vitro studies in vertebrate neurobiology. Emphasizes techniques involving the glass micropipette and other recently developed methods, supplementing easy-to-follow instructions with illustrative schemes, examples of original records, photomicrographs, key word listings, comprehensive reference tables and a list of suppliers and key equipment and reagents.

Spatiotemporal Neural Interface Dynamics Elucidated with Multi Channel Electrochemistry

Spatiotemporal Neural Interface Dynamics Elucidated with Multi Channel Electrochemistry Book
Author : Matthew Douglas Johnson
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Spatiotemporal Neural Interface Dynamics Elucidated with Multi Channel Electrochemistry book written by Matthew Douglas Johnson, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Dissertation Abstracts International

Dissertation Abstracts International Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Government Reports Annual Index

Government Reports Annual Index Book
Author : Anonim
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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EMBC 2004

EMBC 2004 Book
Author : IEEE Engineering in Medicine and Biology Society. Conference,IEEE Engineering in Medicine and Biology Society
Publisher : IEEE Computer Society Press
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"IEEE Catalog Number: 04CH37558"--T.p. verso.

Bioelectronics Directory

Bioelectronics Directory Book
Author : Saul B. Sells
Publisher : Unknown
Release : 1963
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Aerospace Medicine and Biology

Aerospace Medicine and Biology Book
Author : Anonim
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A selection of annotated references to unclassified reports and journal articles that were introduced into the NASA scientific and technical information system and announced in Scientific and technical aerospace reports (STAR) and International aerospace abstracts (IAA).

CSA Neurosciences Abstracts

CSA Neurosciences Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Linguistics and Language Behavior Abstracts

Linguistics and Language Behavior Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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The Dynamic Brain

The Dynamic Brain Book
Author : Timothy Roger Mullen
Publisher : Unknown
Release : 2014
ISBN : 9781321234619
Language : En, Es, Fr & De

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Book Description :

"The mind is the music that neural networks play." This quote from computational neurobiologist T.J. Sejnowski underscores a growing scientific consensus that studying the structure and function of vast networks of connections between brain regions is essential to understanding cognitive and affective state maintenance, sensorimotor information processing and control, etiologies and remedies for numerous neuropathologies, as well as a host of other facets of our conscious (and non-conscious) experience. Towards this goal, an ongoing challenge lies in identifying - in vivo in humans - spatiotemporal cortical network dynamics, at the level of individuals and groups, across experimental task conditions, and at the level of single trials. In the opening chapter of this dissertation, I introduce the Source Information Flow Toolbox (SIFT), a novel open-source software package for identification of neuronal dynamics and causal interactions in electrophysiological source and sensor data. The software integrates with the widely used EEGLAB analysis suite, addressing a need for robust tools for identifying single- and multi-trial multivariate brain network dynamics across time, frequency, anatomical source location, and subjects. I then introduce and assess two new methods (Measure Projection Analysis and Multi-view Hierarchical Bayesian Learning) for statistical analysis of source-level dynamics (including connectivity) across groups of subjects in the presence of missing data. The remaining chapters focus on applications of dynamical modeling approaches in SIFT to open problems within the fields of cognitive neuroscience, clinical neuroscience and neuroengineering. I first present three studies examining single-trial time-varying spatiotemporal network dynamics underlying generation and maintenance of epileptic seizures. Next I present a case study examining the effect of visual feedback on an occipito-parietal-motor network in freezing-of-gait in patients with Parkinson's disease. The final chapters focus on new directions in neuroengineering and brain-computer interfaces (BCI) leveraging neural dynamical system identification. We first review the history and state of the BCI field and summarize important new directions in BCI design. I then present a novel system for real-time mobile brain imaging, artifact rejection, neuronal system identification, and cognitive state prediction, and demonstrate its application in predicting response error commission from cortical network dynamics using a new high-density mobile dry EEG system.

Encyclopedia of Medical Devices and Instrumentation

Encyclopedia of Medical Devices and Instrumentation Book
Author : John G. Webster
Publisher : Wiley-Interscience
Release : 2006-04-07
ISBN : 9780470040683
Language : En, Es, Fr & De

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Book Description :

The articles in The Encyclopedia of Medical Devices and Instrumentation focus on what is currently useful or is likely to be useful in future medicine. They answer the question, What are the branches of medicine and how does technology assist each of them? Articles focus on the practice of medicine that is assisted by devices, rather than including, for example, the use of drugs to treat disease. The title is the only resource on the market dealing with the subject in encyclopedic detail. * Accessible to practitioners with a broad range of backgrounds from students to researchers and physicians * Articles cover the latest developments such as nanotechnology, fiber optics, and signal processing

Journal of the Royal Society Interface

Journal of the Royal Society  Interface Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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