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Ecology And Evolution Of Cancer

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Ecology and Evolution of Cancer

Ecology and Evolution of Cancer Book
Author : Beata Ujvari,Benjamin Roche,Frederic Thomas
Publisher : Academic Press
Release : 2017-02-08
ISBN : 0128043806
Language : En, Es, Fr & De

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Book Description :

Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies

Ecology and Evolution of Cancer

Ecology and Evolution of Cancer Book
Author : Beata Ujvari,Frdric Thomas,Benjamin Roche
Publisher : Academic Press
Release : 2017-03-10
ISBN : 9780128043103
Language : En, Es, Fr & De

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Book Description :

The Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology and cancer, but also goes beyond by connecting the interface of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and development of this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research, The Ecology and Evolution of Cancer is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression and to prevent therapeutic failures. Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as lecturers in evolutionary medicine Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies

Understanding Cancer from a Systems Biology Point of View

Understanding Cancer from a Systems Biology Point of View Book
Author : Irina Kareva
Publisher : Academic Press
Release : 2018-02-07
ISBN : 012813674X
Language : En, Es, Fr & De

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Book Description :

Understanding Cancer from a Systems Biology Point of View: From Observation to Theory and Back starts with a basic question, why do we sometimes observe accelerated metastatic growth after resection of primary tumors? Next, it helps readers understand the systemic nature of cancer and how it affects treatment approaches and decisions. The book puts together aspects of cancer that many readers have most likely never combined, using unfamiliar, novel methods. It is a valuable resource for cancer researchers, cancer biologists, mathematicians and members of the biomedical field who are interested in applying systems biology methodologies for understanding and treating cancer. Explains the systemic nature of cancer and how it affects decisions on treatment Brings a variety of methods together, showing, in detail, the logical approach to finding answers to complex questions Discusses the theoretical underpinnings of cancer as a systemic disease, providing the reader with valuable information on applicable cases

The Cheating Cell

The Cheating Cell Book
Author : Athena Aktipis
Publisher : Princeton University Press
Release : 2021-09-07
ISBN : 0691212198
Language : En, Es, Fr & De

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Book Description :

A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.

Israel Journal of Ecology Evolution

Israel Journal of Ecology   Evolution Book
Author : Anonim
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Israel Journal of Ecology Evolution book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Debating Cancer

Debating Cancer Book
Author : Henry H Heng
Publisher : World Scientific
Release : 2015-10-08
ISBN : 9814520861
Language : En, Es, Fr & De

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Book Description :

Cancer research is at a crossroads. Traditionally, cancer has been thought of as a disease of gene mutation, where the stepwise accumulation of cancer gene mutations is the key, and the identification of common gene mutations has been considered to be essential for diagnosis and treatment. Despite extensive research efforts and accumulated knowledge on cancer genes and pathways, the clinical benefits of this traditional approach have been limited. Recently, cancer genome sequencing has revealed an extensive amount of genetic heterogeneity where the long-expected common mutation drivers have been difficult, if not impossible, to identify. These realities ultimately challenge the conceptual framework of current cancer biology. This book introduces a new concept of genome theory of cancer evolution, in an attempt to unify the field. Many important and representative, but often confusing, questions and paradoxes are critically analyzed. By comparing gene- and genome-based theories, the hidden flaws of many popular viewpoints are addressed. This discussion is intended to initiate a much-needed critical re-evaluation of current cancer research. Contents:Introduction: Why Debate Cancer, and Why Now?The Gene Mutation Theory of CancerAlternative Theories to Explain CancerThe Surprise Cancer Genome Landscape Revealed by Cancer Genome Sequencing ProjectsUnraveling the Mystery of Cancer: Understanding Genome Variation Mediated Cancer EvolutionSignificance of the Insignificant: Why "Noise" is Essential for Cancer EvolutionDo Different Cancers Represent Different Species?Facts vs. Myths Readership: This book will be appreciated by the research community at large. It will also serve as an excellent resource for a wide range of readers, including researchers, graduate students, physicians, science reporters, and even policy-makers. Key Features:Currently, there exists no such book. This title represents a much-needed effort to systematically re-examine many concepts in cancer research which have remained relatively the same for decadesThe topics discussed are well-known paradoxes to researchers (over 50 of them). Addressing these questions will not only provide answers to key puzzles in the field but also introduce a new conceptual framework, the genome-based cancer evolution theoryThis book will encourage new ideas/approaches that bridge basic research and clinical applications. The analysis of provocative questions will spur a long overdue debate on this subjectKeywords:Cancer Evolution;Genome Theory;Cancer Heterogeneity;Cancer Landscape;Cancer Theories;Drug Resistance;Cancer Diagnosis;Cancer Research

Dissecting the Heterogeneity of Breast Tumor Subtypes

Dissecting the Heterogeneity of Breast Tumor Subtypes Book
Author : Nima Pouladi,Dartmouth Medical School. Department of Genetics
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Breast cancer is the most common cancer in women. The discovery of breast tumor subtypes and the subsequent development of treatments aimed at them has allowed a reduction in the mortality of breast cancer. However, tumors with similar characteristics continue to respond differently to the same treatment. Thus, further dissection of breast cancer heterogeneity is necessary and several challenges remain unanswered or unaddressed. First, although tumors are heterogeneous it is not clear whether all tumor traits share similar degrees of heterogeneity. Conversely, we may be missing individual traits that are highly heterogeneous among a majority of homogenous traits in tumor classes we believe to understand. Second, it is not obvious how we can find sets of genes that are integral to the tumor biology i.e. traits that are not allowed be heterogeneous. The identification of traits that are constrained in tumor evolution could allow us to reign the tumor's biology more effectively. Third, to date tumor traits have been identified through a variety of measures, but whether traits can be defined solely on the basis of their heterogeneity remains unaddressed. When defined in this manner, it is unclear which tumor traits could be most variable within each subtype, thus contributing disproportionately to intra-subtype heterogeneity. In order to address these three challenges, we re-analyzed previously generated microarray gene expression data from hundreds of breast tumors. Our analytic approaches employ methods developed in the fields of network theory, ecology and evolutionary biology. We address the first challenge by showing that breast cancer heterogeneity is contained in gene modules. This modular heterogeneity increases monotonically across subtypes. We identify a core of two modules that are shared among all subtypes and a number of subtype-specific modules. The genes contained by the core are involved in nucleosome assembly and mammary morphogenesis. Furthermore, our analysis shows that a higher degree of global heterogeneity does not imply a high heterogeneity for all modules. Therefore, tumor traits show independence from each other in their degree of heterogeneity. We then address the second challenge by quantifying the relative degree of constraint for tumor traits. We do this in triple negative breast cancer (TNBC); the subtype which has the poorest prognosis. We also examine how strongly tumor traits are interconnected. In this manner, we show that the module for cellular immune responses has the highest degree of integration. This implies that its genes are tightly controlled and we therefore propose this module as a bridle through which to exert control over TNBC biology. Finally, we address the third challenge by identifying and functionally characterizing sets of genes based on their heterogeneity. We catalogue these variable tumor traits across all subtypes and show that their order of variability is subtype-specific. Through these three projects we lay a foundation for the rigorous dissection of tumor heterogeneity across the vast space of the transcriptome. In doing so we identify and rank sets of genes for their potential utility in further dissecting or more effectively treating specific breast cancer subtypes.

Frontiers in Ecology Evolution and Complexity

Frontiers in Ecology  Evolution and Complexity Book
Author : Mariana Benítez,Octavio Miramontes,Alfonso Valiente-Banuet
Publisher : CopIt ArXives
Release : 2014-07-08
ISBN : 1938128052
Language : En, Es, Fr & De

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Book Description :

Advances in molecular biology, remote sensing, systems biology, bioinformatics, non-linear science, the physics of complex systems and other fields have rendered a great amount of data that remain to be integrated into models and theories that are capable of accounting for the complexity of ecological systems and the evolutionary dynamics of life. It is thus necessary to provide a solid basis to discuss and reflect on these and other challenges both at the local and global scales. This volume aims to delineate an integrative and interdisciplinary view that suggests new avenues in research and teaching, critically discusses the scope of the diverse methods in the study of complex systems, and points at key open questions. Finally, this book will provide students and specialists with a collection of high quality open access essays that will contribute to integrate Ecology, Evolution and Complexity in the context of basic research and in the field of Sustainability Sciences.

A Biologist s Guide to Mathematical Modeling in Ecology and Evolution

A Biologist s Guide to Mathematical Modeling in Ecology and Evolution Book
Author : Sarah P. Otto,Troy Day
Publisher : Princeton University Press
Release : 2011-09-19
ISBN : 1400840910
Language : En, Es, Fr & De

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Book Description :

Thirty years ago, biologists could get by with a rudimentary grasp of mathematics and modeling. Not so today. In seeking to answer fundamental questions about how biological systems function and change over time, the modern biologist is as likely to rely on sophisticated mathematical and computer-based models as traditional fieldwork. In this book, Sarah Otto and Troy Day provide biology students with the tools necessary to both interpret models and to build their own. The book starts at an elementary level of mathematical modeling, assuming that the reader has had high school mathematics and first-year calculus. Otto and Day then gradually build in depth and complexity, from classic models in ecology and evolution to more intricate class-structured and probabilistic models. The authors provide primers with instructive exercises to introduce readers to the more advanced subjects of linear algebra and probability theory. Through examples, they describe how models have been used to understand such topics as the spread of HIV, chaos, the age structure of a country, speciation, and extinction. Ecologists and evolutionary biologists today need enough mathematical training to be able to assess the power and limits of biological models and to develop theories and models themselves. This innovative book will be an indispensable guide to the world of mathematical models for the next generation of biologists. A how-to guide for developing new mathematical models in biology Provides step-by-step recipes for constructing and analyzing models Interesting biological applications Explores classical models in ecology and evolution Questions at the end of every chapter Primers cover important mathematical topics Exercises with answers Appendixes summarize useful rules Labs and advanced material available

Cancer and Society

Cancer and Society Book
Author : Eric H. Bernicker
Publisher : Springer
Release : 2019-03-04
ISBN : 3030058557
Language : En, Es, Fr & De

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Book Description :

While a number of books have looked at the intersection between human health in general and other topics, such as climate change or diet, this book focuses specifically on cancer as it impacts and is impacted by social justice issues. The massive explosion of research knowledge of cancer immunology and genomics is holding out great promise of therapeutic advances, yet other human actions—climate change, pollution, business decisions, advertising – are fostering health inequalities as well as increasing risks. Those involved in cancer care and research are in a unique position to let their experiences and knowledge inform the public, yet very often have not taken strong public roles when it comes to discussing issues surrounding tobacco, climate change and health risks, financial toxicity of treatments, and diet choices. Written by a multidisciplinary team of authors and for medical oncologists, cancer researchers, occupational health workers, and related medical students, residents, and fellows, this book encourages oncologists to address public health care and the societal issues associated with cancer risk. This volume discusses the overarching theme of environmental justice and oncology, focuses on business and cancer (such as clinical trials, drug development and profits, and global disparities), as well as animals and cancer.

Body by Darwin

Body by Darwin Book
Author : Jeremy Taylor
Publisher : University of Chicago Press
Release : 2015-10-22
ISBN : 022605991X
Language : En, Es, Fr & De

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Book Description :

We think of medical science and doctors as focused on treating conditions—whether it’s a cough or an aching back. But the sicknesses and complaints that cause us to seek medical attention actually have deeper origins than the superficial germs and behaviors we regularly fault. In fact, as Jeremy Taylor shows in Body by Darwin, we can trace the roots of many medical conditions through our evolutionary history, revealing what has made us susceptible to certain illnesses and ailments over time and how we can use that knowledge to help us treat or prevent problems in the future. In Body by Darwin, Taylor examines the evolutionary origins of some of our most common and serious health issues. To begin, he looks at the hygiene hypothesis, which argues that our obsession with anti-bacterial cleanliness, particularly at a young age, may be making us more vulnerable to autoimmune and allergic diseases. He also discusses diseases of the eye, the medical consequences of bipedalism as they relate to all those aches and pains in our backs and knees, the rise of Alzheimer’s disease, and how cancers become so malignant that they kill us despite the toxic chemotherapy we throw at them. Taylor explains why it helps to think about heart disease in relation to the demands of an ever-growing, dense, muscular pump that requires increasing amounts of nutrients, and he discusses how walking upright and giving birth to ever larger babies led to a problematic compromise in the design of the female spine and pelvis. Throughout, he not only explores the impact of evolution on human form and function, but he integrates science with stories from actual patients and doctors, closely examining the implications for our health. As Taylor shows, evolutionary medicine allows us think about the human body and its adaptations in a completely new and productive way. By exploring how our body’s performance is shaped by its past, Body by Darwin draws powerful connections between our ancient human history and the future of potential medical advances that can harness this knowledge.

Population Genomics Wildlife

Population Genomics  Wildlife Book
Author : Paul A. Hohenlohe,Om P. Rajora
Publisher : Springer Nature
Release : 2020-12-09
ISBN : 3030634892
Language : En, Es, Fr & De

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Book Description :

Population genomics is revolutionizing wildlife biology, conservation, and management by providing key and novel insights into genetic, population and landscape-level processes in wildlife, with unprecedented power and accuracy. This pioneering book presents the advances and potential of population genomics in wildlife, outlining key population genomics concepts and questions in wildlife biology, population genomics approaches that are specifically applicable to wildlife, and application of population genomics in wildlife population and evolutionary biology, ecology, adaptation and conservation and management. It is important for students, researchers, and wildlife professionals to understand the growing set of population genomics tools that can address issues from delineation of wildlife populations to assessing their capacity to adapt to environmental change. This book brings together leading experts in wildlife population genomics to discuss the key areas of the field, as well as challenges, opportunities and future prospects of wildlife population genomics.

The Evolution of Size dependent Habitat Use in Cancer Crabs microform Evidence from Phylogenetics Natural Selection Analysis and Behavioural Ecology

The Evolution of Size dependent Habitat Use in Cancer Crabs  microform    Evidence from Phylogenetics  Natural Selection Analysis  and Behavioural Ecology Book
Author : Michelle Katherine Harrison
Publisher : National Library of Canada = Bibliothèque nationale du Canada
Release : 1997
ISBN : 9780612241503
Language : En, Es, Fr & De

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Book Description :

Download The Evolution of Size dependent Habitat Use in Cancer Crabs microform Evidence from Phylogenetics Natural Selection Analysis and Behavioural Ecology book written by Michelle Katherine Harrison, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Modeling Evolution of Heterogeneous Populations

Modeling Evolution of Heterogeneous Populations Book
Author : Irina Kareva,Georgy Karev
Publisher : Academic Press
Release : 2019-10-16
ISBN : 0128144327
Language : En, Es, Fr & De

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Book Description :

Modeling Evolution of Heterogeneous Populations: Theory and Applications describes, develops and provides applications of a method that allows incorporating population heterogeneity into systems of ordinary and discrete differential equations without significantly increasing system dimensionality. The method additionally allows making use of results of bifurcation analysis performed on simplified homogeneous systems, thereby building on the existing body of tools and knowledge and expanding applicability and predictive power of many mathematical models. Introduces Hidden Keystone Variable (HKV) method, which allows modeling evolution of heterogenous populations, while reducing multi-dimensional selection systems to low-dimensional systems of differential equations Demonstrates that replicator dynamics is governed by the principle of maximal relative entropy that can be derived from the dynamics of selection systems instead of being postulated Discusses mechanisms behind models of both Darwinian and non-Darwinian selection Provides examples of applications to various fields, including cancer growth, global demography, population extinction, tragedy of the commons and resource sustainability, among others Helps inform differences in underlying mechanisms of population growth from experimental observations, taking one from experiment to theory and back

Systems Biology of Tumor Microenvironment

Systems Biology of Tumor Microenvironment Book
Author : Katarzyna A. Rejniak
Publisher : Springer
Release : 2016-10-13
ISBN : 3319420232
Language : En, Es, Fr & De

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Book Description :

This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be of interest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology.

North Pacific Workshop on Stock Assessment and Management of Invertebrates

North Pacific Workshop on Stock Assessment and Management of Invertebrates Book
Author : Canada. Department of Fisheries and Oceans. Pacific Region,International Development Research Centre (Canada)
Publisher : Department of Fisheries and Oceans, Information and Publications Branch
Release : 1986
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Various papers are presented on the topics of invertebrate management ingeneral; the sampling of adults, juveniles and larval forms;population dynamics and models; exploration and multispecies interactions;and management strategies. An overall workshop summary is included.

Frontiers in Cancer Research

Frontiers in Cancer Research Book
Author : Carlo C. Maley,Mel Greaves
Publisher : Springer
Release : 2016-11-21
ISBN : 1493964607
Language : En, Es, Fr & De

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Book Description :

This is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diversity within tumors (intra-tumor heterogeneity), understanding how mutant clones expand in tissues, the role of cancer stem cells in the dynamics of tumors, the evolution of metastasis, and how to improve cancer therapy by addressing the evolution of cancers in response to our interventions. There are also chapters on the patterns of cancer susceptibility in humans due to a mismatch between our modern environment and the environment in which our ancestors evolved, as well as a chapter on the evolution of cancer suppression mechanisms that have evolved in different species, particularly the large long-lived animals like elephants and whales that are better at suppressing cancers than humans. This book serves as a primer on the evolutionary and ecological theory of cancer- the framework upon which all the details of cancer may be hung. It is ideal for oncologists and cancer researchers interested in evolutionary theory, and evolutionary biologists and ecologists interested in gaining insights into cancer development and prevention.

Evolutionary Dynamics of Cancer

Evolutionary Dynamics of Cancer Book
Author : Ali Mahdipour Shirayeh
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Despite significant advances in the study of cancer and associated combination therapeutic treatments, cancer still remains one of the most common and complex often-terminal diseases. Acquisition of high-throughput experimental data from diverse cellular perspectives has thrown light on some of the regulatory mechanisms underlying the development of cancer. However, in general there is a lack of a general pattern and coherent model which can explain the development and evolution of the disease. To this end, evolutionary dynamics has been used, as a mathematical tool, in numerous studies to model various aspects of cancer over time periods. Our main focus in this thesis is on the use of stochastic and statistic methods to study cellular interactions within cancer tissues in order to understand the role of spatial structure, heterogeneity, and the microenvironment in cancer development. By constructing multi-cellular structures and using both analytic calculations and stochastic simulations, we have investigated the phenotypic hierarchy of stem cells within a heterogeneous system and in the presence of environmentally induced plasticity. Moreover, the effect of a random environment on the development of cancer has been explored in a general framework. As an important application of the multi-stage hierarchical model, the structure of the colonic/intestinal crypt has been taken into account to show the crucial role of these stem cells in the initiation and progression of colorectal/intestinal cancer. From an alternative viewpoint, we have envisaged the hierarchy of mutations as an evolutionary mechanism in the context of acute myeloid leukemia and carried out a statistical analysis of genetic data. Our findings in this thesis are general and most likely have many implications across a wide array of fields including different blood and solid cancers, bacterial growth, drug resistance and social networks. Moreover, the introduced methods and analyses should have important applications in diverse branches of evolution, ecology, and population genetics.

Unsolved Problems in Ecology

Unsolved Problems in Ecology Book
Author : Andrew Dobson,David Tilman,Robert D. Holt
Publisher : Princeton University Press
Release : 2020-06-02
ISBN : 0691195323
Language : En, Es, Fr & De

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Book Description :

Leading ecologists discuss some of the most compelling open questions in the field today Unsolved Problems in Ecology brings together many of the world's leading ecologists to discuss the most fundamental research questions confronting the field today. This diverse and thought-provoking collection of essays spans virtually all of the key subfields of the discipline, from behavioral and evolutionary ecology to population biology, community ecology, ecosystem ecology, disease ecology, and conservation biology. These essays are intended to stoke curiosity, challenge prevailing wisdom, and provoke new ways of thinking about ecology in light of new technologies and unprecedented environmental challenges brought on by climate and land-use change. Authoritative and accessible, Unsolved Problems in Ecology is ideal for graduate students in the early stages of their scientific careers and an essential resource for seasoned ecologists looking for exciting new directions to take their research. Sheds light on modern ecology's most important and compelling open questions Features thought-provoking contributions from more than two dozen world-class ecologists Covers behavior, evolution, communities, ecosystems, resource management, and more Discusses ways to raise the financial and intellectual profile of the discipline An invaluable resource for graduate students as well as seasoned ecologists

Novel Approaches to Colorectal Cancer

Novel Approaches to Colorectal Cancer Book
Author : Anonim
Publisher : Academic Press
Release : 2021-06-18
ISBN : 0128240792
Language : En, Es, Fr & De

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Book Description :

Novel Approaches to Colorectal Cancer, Volume 151 in the Advances in Cancer Research series, is composed of 11 reviews covering state-of-the-art research relating to the etiology, diagnosis, prevention and treatment of colorectal cancer. The book's chapters were written by recognized experts in the field, and include sections on molecular biomarkers in diagnosis and therapy, the interplay of diet, lifestyle, and the microbiome, early-age onset disease, mutational signature analysis, challenges in early detection, immunotherapy, organoid technology, the role of epigenetic alterations, disparities in minority populations, field carcinogenesis, and cancer as an evolutionary process. Each of these topics provides novel insights and concepts on various aspects of the nature of colorectal cancer, offering new opportunities for the management of a major source of cancer incidence and mortality. Provides information on the timely nature of the included topics, which represent the most current concepts and approaches in cancer research Offers outstanding and original reviews on colorectal cancer research Provides the authority and expertise of the authors, all of whom are highly recognized and conducting state-of-the-art investigations in cancer, with this release focusing on colorectal cancer