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Ecology And Evolution Of Cancer

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Ecology and Evolution of Cancer

Ecology and Evolution of Cancer Book
Author : Beata Ujvari,Benjamin Roche,Frederic Thomas
Publisher : Academic Press
Release : 2017-02-08
ISBN : 0128043806
Language : En, Es, Fr & De

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Book Description :

Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies

The Cheating Cell

The Cheating Cell Book
Author : Athena Aktipis
Publisher : Princeton University Press
Release : 2020-03-24
ISBN : 0691163847
Language : En, Es, Fr & De

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Book Description :

A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.

Cancer Evolution

Cancer Evolution Book
Author : Charles Swanton
Publisher : Perspectives Cshl
Release : 2017
ISBN : 9781621821434
Language : En, Es, Fr & De

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Book Description :

Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.

From Ecology to Cancer Biology and Back Again

From Ecology to Cancer Biology and Back Again Book
Author : Frederick R. Adler,Sarah R. Amend,Christopher J. Whelan,Etienne Baratchart
Publisher : Frontiers Media SA
Release : 2022-03-08
ISBN : 2889746151
Language : En, Es, Fr & De

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Download From Ecology to Cancer Biology and Back Again book written by Frederick R. Adler,Sarah R. Amend,Christopher J. Whelan,Etienne Baratchart, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Adaptive Oncogenesis

Adaptive Oncogenesis Book
Author : James DeGregori
Publisher : Harvard University Press
Release : 2018-03-09
ISBN : 0674545397
Language : En, Es, Fr & De

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Book Description :

Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancerÕs occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecosystem of the bodyÕs tissues. His theory ties cancerÕs progression, or lack thereof, to evolved strategies to maximize reproductive success. Through natural selection, humans evolved genetic programs to maintain bodily health for as long as necessary to increase the odds of passing on our genesÑbut not much longer. These mechanisms engender a tissue environment that favors normal stem cells over precancerous ones. Healthy tissues thwart cancer cellsÕ ability to outcompete their precancerous rivals. But as our tissues age or accumulate damage from exposures such as smoking, normal stem cells find themselves less optimized to their ecosystem. Cancer-causing mutations can now help cells adapt to these altered tissue environments, and thus outcompete normal cells. Just as changes in a speciesÕ habitat favor the evolution of new species, changes in tissue environments favor the growth of cancerous cells. DeGregoriÕs perspective goes far in explaining who gets cancer, when it appears, and why. While we cannot avoid mutations, it may be possible to sustain our tissuesÕ natural and effective system of defense, even in the face of aging or harmful exposures. For those interested in learning how cancers arise within the human body, the insights in Adaptive Oncogenesis offer a compelling perspective.

Cancer Ecosystems

Cancer Ecosystems Book
Author : Ubaldo E. Martinez-Outschoorn,Ramon Bartrons
Publisher : Frontiers Media SA
Release : 2019-11-27
ISBN : 2889631753
Language : En, Es, Fr & De

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Book Description :

Download Cancer Ecosystems book written by Ubaldo E. Martinez-Outschoorn,Ramon Bartrons, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

New Horizons in Evolution

New Horizons in Evolution Book
Author : Solomon P. Wasser,Milana Frenkel-Morgenstern
Publisher : Academic Press
Release : 2021-07-30
ISBN : 0323907539
Language : En, Es, Fr & De

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Book Description :

New Horizons in Evolution is a compendium of the latest research, analyses, and theories of evolutionary biology. Chapters are collected from the international symposium held by the Board of Governors of the University of Haifa to honor Dr. Eviatar Nevo, founder and director of the Institute of Evolution. This book includes material written by top global scientists. Such detailed summaries and recent advances include topics like genomics, epigenetics, evolutionary theory, and the evolution of cancer. This book analyzes evolutionary biology of animals, such as lizards and subterranean mammals. It also discusses agricultural evolution, specifically the vital wheat crop in various climates and locations. Each chapter contributes the most up-to-date knowledge of evolution’s role in speciation, adaptation, and regulation. New Horizons in Evolution is a valuable resource for researchers involved in evolution, evolutionary biology, and evolutionary theory. Advanced undergraduate and graduate students in evolutionary biology courses will also find this useful due to the high expertise level and latest knowledge available through this resource. Examines the evolution of species in extreme conditions Discusses the role of evolution in medicine and cancer research Features the latest data and advances in evolution theory

Explaining Cancer

Explaining Cancer Book
Author : Anya Plutynski
Publisher : Oxford University Press
Release : 2018-07-18
ISBN : 0190904585
Language : En, Es, Fr & De

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Book Description :

In Explaining Cancer, Anya Plutynski addresses a variety of philosophical questions that arise in the context of cancer science and medicine. She begins with the following concerns: · How do scientists classify cancer? Do these classifications reflect nature's "joints"? · How do cancer scientists identify and classify early stage cancers? · What does it mean to say that cancer is a "genetic" disease? What role do genes play in "mechanisms for" cancer? · What are the most important environmental causes of cancer, and how do epidemiologists investigate these causes? · How exactly has our evolutionary history made us vulnerable to cancer? Explaining Cancer uses these questions as an entrée into a family of philosophical debates. It uses case studies of scientific practice to reframe philosophical debates about natural classification in science and medicine, the problem of drawing the line between disease and health, mechanistic reasoning in science, pragmatics and evidence, the roles of models and modeling in science, and the nature of scientific explanation.

Oxford Textbook of Cancer Biology

Oxford Textbook of Cancer Biology Book
Author : Francesco Pezzella,Mahvash Tavassoli,David Kerr
Publisher : Oxford University Press
Release : 2019-05-02
ISBN : 0198779453
Language : En, Es, Fr & De

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Book Description :

The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside biologists, geneticists, and clinicians. The Oxford Textbook of Cancer Biology brings together the most up-to-date developments from different branches of research into one coherent volume, providing a comprehensive and current account of this rapidly evolving field. Structured in eight sections, the book starts with a review of the development and biology of multi-cellular organisms, how they maintain a healthy homeostasis in an individual, and a description of the molecular basis of cancer development. The book then illustrates, as once cells become neoplastic, their signalling network is altered and pathological behaviour follows. It explores the changes that cancer cells can induce in nearby normal tissue, the new relationship established between them and the stroma, and the interaction between the immune system and tumour growth. The authors illustrate the contribution provided by high throughput techniques to map cancer at different levels, from genomic sequencing to cellular metabolic functions, and how information technology, with its vast amounts of data, is integrated with traditional cell biology to provide a global view of the disease. The effect of the different types of treatments on the biology of the neoplastic cells are explored to understand on the one side, why some treatments succeed, and on the other, how they can affect the biology of resistant and recurrent disease. The book concludes by summarizing what we know to date about cancer, and in what direction our understanding of cancer is moving. Edited by leading authorities in the field with an international team of contributors, this book is an essential resource for scholars and professionals working in the wide variety of sub-disciplines that make up today's cancer research and treatment community. It is written not only for consultation, but also for easy cover-to-cover reading.

Polyploidization and Cancer

Polyploidization and Cancer Book
Author : Randy Y.C. Poon
Publisher : Springer Science & Business Media
Release : 2011-01-11
ISBN : 1441961992
Language : En, Es, Fr & De

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Book Description :

Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.

Rebel Cell

Rebel Cell Book
Author : Kat Arney
Publisher : BenBella Books
Release : 2020-10-20
ISBN : 1950665518
Language : En, Es, Fr & De

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Book Description :

Why do we get cancer? Is it our modern diets and unhealthy habits? Chemicals in the environment? An unwelcome genetic inheritance? Or is it just bad luck? The answer is all of these and none of them. We get cancer because we can't avoid it—it's a bug in the system of life itself. Cancer exists in nearly every animal and has afflicted humans as long as our species has walked the earth. In Rebel Cell: Cancer, Evolution, and the New Science of Life's Oldest Betrayal, Kat Arney reveals the secrets of our most formidable medical enemy, most notably the fact that it isn't so much a foreign invader as a double agent: cancer is hardwired into the fundamental processes of life. New evidence shows that this disease is the result of the same evolutionary changes that allowed us to thrive. Evolution helped us outsmart our environment, and it helps cancer outsmart its environment as well—alas, that environment is us. Explaining why "everything we know about cancer is wrong," Arney, a geneticist and award-winning science writer, guides readers with her trademark wit and clarity through the latest research into the cellular mavericks that rebel against the rigid biological "society" of the body and make a leap towards anarchy. We need to be a lot smarter to defeat such a wily foe—smarter even than Darwin himself. In this new world, where we know that every cancer is unique and can evolve its way out of trouble, the old models of treatment have reached their limits. But we are starting to decipher cancer's secret evolutionary playbook, mapping the landscapes in which these rogue cells survive, thrive, or die, and using this knowledge to predict and confound cancer's next move. Rebel Cell is a story about life and death, hope and hubris, nature and nurture. It's about a new way of thinking about what this disease really is and the role it plays in human life. Above all, it's a story about where cancer came from, where it's going, and how we can stop it.

The Cheating Cell

The Cheating Cell Book
Author : Athena Aktipis
Publisher : Princeton University Press
Release : 2021-09-07
ISBN : 0691212198
Language : En, Es, Fr & De

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Book Description :

A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.

Understanding Cancer from a Systems Biology Point of View

Understanding Cancer from a Systems Biology Point of View Book
Author : Irina Kareva
Publisher : Academic Press
Release : 2018-02-07
ISBN : 012813674X
Language : En, Es, Fr & De

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Book Description :

Understanding Cancer from a Systems Biology Point of View: From Observation to Theory and Back starts with a basic question, why do we sometimes observe accelerated metastatic growth after resection of primary tumors? Next, it helps readers understand the systemic nature of cancer and how it affects treatment approaches and decisions. The book puts together aspects of cancer that many readers have most likely never combined, using unfamiliar, novel methods. It is a valuable resource for cancer researchers, cancer biologists, mathematicians and members of the biomedical field who are interested in applying systems biology methodologies for understanding and treating cancer. Explains the systemic nature of cancer and how it affects decisions on treatment Brings a variety of methods together, showing, in detail, the logical approach to finding answers to complex questions Discusses the theoretical underpinnings of cancer as a systemic disease, providing the reader with valuable information on applicable cases

Cancer

Cancer Book
Author : Mel Greaves
Publisher : Oxford University Press on Demand
Release : 2001
ISBN : 9780192628343
Language : En, Es, Fr & De

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Book Description :

In this fascinating and highly readable new book, Mel Greaves shows how the origins of cancer are inextricably linked with our evolutionary heritage, and considers the implications of this theory for future research and treatment.

Molecular Portraits of Cancer Evolution and Ecology

Molecular Portraits of Cancer Evolution and Ecology Book
Author : Dhruva Biswas
Publisher : Unknown
Release : 2021
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Molecular Portraits of Cancer Evolution and Ecology book written by Dhruva Biswas, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Targeted Cancer Treatment in Silico

Targeted Cancer Treatment in Silico Book
Author : Natalia L. Komarova,Dominik Wodarz
Publisher : Springer Science & Business Media
Release : 2013-11-19
ISBN : 1461483018
Language : En, Es, Fr & De

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Book Description :

Countless medical researchers over the past century have been occupied by the search for a cure of cancer. So far, they have developed and implemented a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, small molecule inhibitors, and oncolytic viruses. However, patterns of these treatments' effectiveness remain largely unclear, and a better understanding of how cancer therapies work has become a key research goal. Cancer Treatment in Silico provides the first in-depth study of approaching this understanding by modeling cancer treatments, both mathematically and through computer simulations. The main goal of this book is to help expose students and researchers to in silico methods of studying cancer. It is intended for both the applied mathematics and experimental oncology communities, as mathematical models are playing an increasingly important role to supplement laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, the work will be a valuable resource for scientists and students alike.

Cancer Epidemiology and Prevention

Cancer Epidemiology and Prevention Book
Author : Michael Thun,Martha S. Linet,James R. Cerhan,Christopher A. Haiman,David Schottenfeld
Publisher : Oxford University Press
Release : 2017-11-14
ISBN : 0190238666
Language : En, Es, Fr & De

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Book Description :

Since its initial publication in 1982, CANCER EPIDEMIOLOGY AND PREVENTION has served as the premier reference work for students and professionals working to understand the causes and prevention of cancer in humans. Now revised for the first time in more than a decade, this fourth edition provides a comprehensive summary of the global patterns of cancer incidence and mortality, current understanding of the major causal determinants, and a rationale for preventive interventions. Special attention is paid tomolecular epidemiologic approaches that address the wider role of genetic predisposition and gene-environment interactions in cancer etiology and pathogenesis. New and timely chapters on environmental and social-epidemiologic factors include: * The role of social class disparities* The role of obesity and physical inactivity* The potential effects of electromagnetic fields and radiofrequency radiation* The principles of cancer chemopreventionFor both seasoned professionals and newer generations of students and researchers, this fourth edition of CANCER EPIDEMIOLOGY AND PREVENTION remains the authority in the field - a work of distinction that every lab, library, student, professional, or researcher should have close at hand.

The Emperor of All Maladies

The Emperor of All Maladies Book
Author : Siddhartha Mukherjee
Publisher : Simon and Schuster
Release : 2011-08-09
ISBN : 1439170916
Language : En, Es, Fr & De

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Book Description :

An assessment of cancer addresses both the courageous battles against the disease and the misperceptions and hubris that have compromised modern understandings, providing coverage of such topics as ancient-world surgeries and the development of present-day treatments. Reprint. Best-selling winner of the Pulitzer Prize. Includes reading-group guide.

Evolution in Health and Disease

Evolution in Health and Disease Book
Author : Stephen C. Stearns,Jacob C. Koella
Publisher : Oxford University Press
Release : 2008
ISBN : 9780199207459
Language : En, Es, Fr & De

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Book Description :

This work explores and analyses the ways in which our ancient genes contend with, and influence, modern human life. It offers coverage of the points of contact between evolutionary biology and medical science.

Oxford Textbook of Oncology

Oxford Textbook of Oncology Book
Author : David J. Kerr,Daniel G. Haller,Cornelis J. H. van de Velde,Michael Baumann
Publisher : Oxford University Press
Release : 2016-01-28
ISBN : 0191065110
Language : En, Es, Fr & De

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Book Description :

Now in paperback, the Oxford Textbook of Oncology reflects current best practice in the multidisciplinary management of cancer, written and edited by internationally recognised leaders in the field. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.