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Early Detection In Alzheimers Disease

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Finding the Path in Alzheimer s Disease

Finding the Path in Alzheimer   s Disease Book
Author : Sharon Cohen, MD, FRCPC,R. Scott Turner, MD, PhD
Publisher : Integritas Communications
Release : 2020-11-19
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

AD is a common neurodegenerative condition that results in a range of profoundly disabling cognitive, affective, and behavioral symptoms. It affects approximately 5.8 million Americans. Barring significant clinical efforts and medical breakthroughs that prevent or slow disease development, current estimates suggest that by 2050, AD will afflict 14 million patients in the United States. PCPs are on the front lines of early diagnosis of AD, yet many say they feel unprepared and their community lacks adequate specialists in this area. Signs and symptoms of mild cognitive impairment (MCI) and even early AD are often conflated with normal aging, leading to late or missed diagnosis. This is compounded by the lack of a sense of urgency for early, accurate diagnosis because there are no disease-modifying therapies to treat MCI or AD. This eHealth Source activity reviews the pathophysiology of AD, early signs and symptoms, diagnosis first steps, referral patterns, more-complex diagnostic procedures, and existing nonpharmacologic and pharmacologic management strategies. Drs Cohen and Turner provide expert insight into how PCPs can tailor their practice to better care for these patients.

Early Diagnosis and Intervention in Predementia Alzheimer s Disease An Issue of Medical Clinics

Early Diagnosis and Intervention in Predementia Alzheimer s Disease  An Issue of Medical Clinics  Book
Author : Jose L. Molinuevo,Jeffrey I. Cummings,Bruno Dubois,Philip Scheltens
Publisher : Elsevier Health Sciences
Release : 2013-05-11
ISBN : 1455772038
Language : En, Es, Fr & De

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Book Description :

This issue of Medical Clinics covers the important advances surrounding the early intervention of Alzheimer's Disease. Guest edited by world-renowned experts from around the world, the topics covered will include evaluation of new diagnostic criteria, CSF biomarkers, diagnostic imaging, neurocognitive approaches, breaking clinical trials and more.

Alzheimer s Turning Point

Alzheimer   s Turning Point Book
Author : Jack C. de la Torre
Publisher : Springer
Release : 2016-06-25
ISBN : 3319340573
Language : En, Es, Fr & De

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Book Description :

This compelling text provides an overview of the available technology for early detection and therapeutic management of vascular risk factors to Alzheimer’s before severe cognitive impairment symptoms appear. Chapters bring the reader from the trackless clinical research that has characterized Alzheimer’s progress for the last 20 years, to a nexus of new ideas and concepts that can change our outlook of this dementia. In-depth examinations of various hypotheses, preventive measures, current and prospective treatments are openly and clearly explored. The author discusses in depth his proposal of the vascular hypothesis of Alzheimer's disease which has become a mother-lode for basic and clinical studies and a key approach to the prevention of this dementia.Alzheimer’s Turning Point offers professionals, students and those looking to learn more about this disorder a fresh clinical perspective of this devastating disease.

Preclinical Evaluation of Potential Monoamine Oxidase B MAO B Inhibitors for PET Application

Preclinical Evaluation of Potential Monoamine Oxidase B  MAO B  Inhibitors for PET Application Book
Author : Marko Grahovac
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Alzheimers is a progressive yet incurable disease that inflicts millions of people throughout the world leading to a decline in the simplest activities of daily living and quality of life. Early detection prolongs a patients quality of life and therefore, Positron emission tomography (PET) tracers for diagnosing Alzheimers disease in the early stages are in demand. It is important to note that elevated level of Monoamine oxidase B (MAO-B) has been detected in Alzheimers patients, and consequently MAO-B could be a target of interest. Newly developed potential MAO-B inhibitors will be tested for pharmacokinetic properties (lipophilicity and permeability) using High performance liquid chromatography (HPLC). Moreover,the inhibitors with the greatest properties (candidates) will be tested for metabolic stability by different enzyme assays. The aim is to investigate the most potent candidates, which could then be used for radiolabeling needed for the development of PET tracers for the diagnosis of Alzheimers disease.*****Alzheimers is a progressive yet incurable disease that inflicts millions of people throughout the world leading to a decline in the simplest activities of daily living and quality of life. Early detection prolongs a patients quality of life and therefore, Positron emission tomography (PET) tracers for diagnosing Alzheimers disease in the early stages are in demand. It is important to note that elevated level of Monoamine oxidase B (MAO-B) has been detected in Alzheimers patients, and consequently MAO-B could be a target of interest. Newly developed potential MAO-B inhibitors will be tested for pharmacokinetic properties (lipophilicity and permeability) using High performance liquid chromatography (HPLC). Moreover,the inhibitors with the greatest properties (candidates) will be tested for metabolic stability by different enzyme assays. The aim is to investigate the most potent candidates, which could then be used for radiolabeling needed for the development of PET tracers for the diagnosis of Alzheimers disease.

Alzheimers Test and Prevention

Alzheimers Test and Prevention Book
Author : Brian Jeff
Publisher : Createspace Independent Publishing Platform
Release : 2016-10-13
ISBN : 9781539500377
Language : En, Es, Fr & De

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Book Description :

There is no doubt that Alzheimer's disease is a complex and complicated illness, and the reason for this is that most of its symptoms are frequently indicative of other disorders as well! Well, as a result, the diagnostic process for the disease can be really messy and complicated if you know what I mean. And as a matter of fact, at this time, the only definitive way to diagnose Alzheimer's disease is to examine brain tissue for plaques and tangles. But, let me quickly say that this is rather unfortunate! And you should know why... yes, because so far, this can only be done in an autopsy! So you might be wondering... "How then is Alzheimer's disease diagnosed?" Well, doctors must do what they have to do to get the right diagnosis... so they have to conduct a thorough examination so that they can rule out other possible causes of the symptoms you are experiencing. Therefore, to a larger extent, I want to say that a diagnosis can be considered "reasonable" if all other causes cannot be excluded. But same can be considered "probable" if all other causes have been ruled out. Fortunately, today we have specialists with extensive experience of working with Alzheimer's disease patients that can diagnose Alzheimer's disease with 80-90% certainty. Early Diagnosis - Don't Waste Time before Seeing a Doctor. Yes, according to Dharma Singh Khalsa, M.D., President and Medical Director of the Alzheimer's Disease Research and Prevention Foundation, it is important that you go for a diagnostic examination as soon as symptoms appear. In any case, Dr. Khalsa has found that many of the treatments currently available work best when an early Alzheimer's disease diagnosis is made. Besides that, there are many other advantages to having Alzheimer's disease diagnosed as early as possible. First, early diagnosis help patients and families plan for the future. It gives them time to discuss care options while the patient can still be part of the decision-making process. That will be okay for now... just get your copy of the book today by clicking the buy button above and avail yourself the full details of how to test, prevent and as the case may be, start to manage the condition with ease. Yes, Including Tips To Avoid The Early Onset Alzheimer's And Chronic Alzheimer's Disease Stages Today!

Atlas of Biomarkers for Alzheimer s Disease

Atlas of Biomarkers for Alzheimer s Disease Book
Author : Manuel Menéndez González
Publisher : Springer
Release : 2014-07-07
ISBN : 3319079891
Language : En, Es, Fr & De

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Book Description :

A lot of research on biomarkers for Alzheimer is being done in the last few decades. The aim of these studies is to find some method to ease the diagnosis of Alzheimers as early as possible. Such methods are a range of blood or CSF tests on one hand and several types of neuroimaging scans on the other. Many of the images coming both from laboratory and neuroimaging are very visual and illustrative. These images, accompanied by a short description, can perfectly explain the main results and usefulness of every biomarker. The objective of this book would be to summarize the most important studies made in this field. Few publications have systematically compiled results on this topic and only one as an atlas. Readers would be interested in this publication because it allows reviewing the current status of research by handily visualizing the results.

Alzheimers Test and Prevention

Alzheimers Test and Prevention Book
Author : Brian Jeff
Publisher : Createspace Independent Publishing Platform
Release : 2016-10-21
ISBN : 9781539650539
Language : En, Es, Fr & De

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Book Description :

There is no doubt that Alzheimer's disease is a complex and complicated illness, and the reason for this is that most of its symptoms are frequently indicative of other disorders as well! Well, as a result, the diagnostic process for the disease can be really messy and complicated if you know what I mean. And as a matter of fact, at this time, the only definitive way to diagnose Alzheimer's disease is to examine brain tissue for plaques and tangles. But, let me quickly say that this is rather unfortunate! And you should know why... yes, because so far, this can only be done in an autopsy! So you might be wondering... "How then is Alzheimer's disease diagnosed?" Well, doctors must do what they have to do to get the right diagnosis... so they have to conduct a thorough examination so that they can rule out other possible causes of the symptoms you are experiencing. Therefore, to a larger extent, I want to say that a diagnosis can be considered "reasonable" if all other causes cannot be excluded. But same can be considered "probable" if all other causes have been ruled out. Fortunately, today we have specialists with extensive experience of working with Alzheimer's disease patients that can diagnose Alzheimer's disease with 80-90% certainty. Early Diagnosis - Don't Waste Time before Seeing a Doctor. Yes, according to Dharma Singh Khalsa, M.D., President and Medical Director of the Alzheimer's Disease Research and Prevention Foundation, it is important that you go for a diagnostic examination as soon as symptoms appear. In any case, Dr. Khalsa has found that many of the treatments currently available work best when an early Alzheimer's disease diagnosis is made. Besides that, there are many other advantages to having Alzheimer's disease diagnosed as early as possible. First, early diagnosis help patients and families plan for the future. It gives them time to discuss care options while the patient can still be part of the decision-making process. That will be okay for now... just get your copy of the book today by clicking the buy button above and avail yourself the full details of how to test, prevent and as the case may be, start to manage the condition with ease. Yes, Including Tips To Avoid The Early Onset Alzheimer's And Chronic Alzheimer's Disease Stages Today!

Alzheimer s Disease Modernizing Concept Biological Diagnosis and Therapy

Alzheimer s Disease   Modernizing Concept  Biological Diagnosis and Therapy Book
Author : M.C. Carrillo,H. Hampel
Publisher : Karger Medical and Scientific Publishers
Release : 2012-04-23
ISBN : 3805598033
Language : En, Es, Fr & De

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Book Description :

Expanding knowledge on genetic and epigenetic risk factors is rapidly enhancing our understanding of the complex molecular interactions and systems involved in the pathogenesis of Alzheimer’s disease. In this publication, leading experts discuss emerging novel conceptual models of the disease along with advances in the development of surrogate markers that will not only improve the accuracy of diagnostic technologies but also improve the prospects of developing disease-modifying interventions. The novel framework of the disease presented here highlights research on biological markers as well as efforts to validate technologies for early and accurate detection. It also introduces notion of a complex systems dysfunction that extends beyond prevailing ideas derived from the ‘amyloid’ or ‘tau’ hypotheses.This outstanding publication provides researchers, clinicians, students and other professionals interested in neurodegenerative disorders with a comprehensive update on current trends and future directions in therapy development, with special focus on advances in clinical trial designs.

Alzheimers Disease

Alzheimers Disease Book
Author : Margaret Strock
Publisher : DIANE Publishing
Release : 1996-03
ISBN : 0788127837
Language : En, Es, Fr & De

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Book Description :

Covers: what is Alzheimer's; the diagnosis of Alzheimer's Disease; the search for the cause of Alzheimer's Disease; the treatment of Alzheimer's Disease; and hope for the future through research. Glossary, references, and sources of help. Illustrated. Also includes a 28-page guide, "Early Identification of Alzheimer's Disease and Related Dementias."

Alzheimer s Disease

Alzheimer   s Disease Book
Author : Ralph W. Richter,Brigitte Zoeller Richter
Publisher : Humana Press
Release : 2013-03-24
ISBN : 9781475744859
Language : En, Es, Fr & De

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Book Description :

Alzheimer’s disease (AD) is a devastating and dehumanizing illness affecting increasingly large numbers of elderly and even middle-aged persons in a worldwide epidemic. Alzheimer’s Disease: A Physician’s Guide to Practical Management was written by selected clinicians and scientists who represent some of the world’s leading centers of excellence in AD research. The editors are proud and grateful for their profound contributions. This book is particularly designed to assist physicians and other health-care professionals in the evaluation, assessment, and treatment of individuals with AD. At the same time, by illuminating the basic scientific background, we hope to provide state-of-the art information about the disease and possible future therapeutic strategies. The recent psychiatric treatment aspects of AD are also clearly presented. Because the early diagnosis of the dementia process is now considered of increasing importance, we focus particularly in several chapters on early changes and preclinical conditions, such as mild cognitive impairment and predementia AD.

Atlas of Biomarkers for Alzheimer s Disease

Atlas of Biomarkers for Alzheimer s Disease Book
Author : Manuel Menéndez
Publisher : Springer
Release : 2014-07-24
ISBN : 9783319079882
Language : En, Es, Fr & De

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Book Description :

A lot of research on biomarkers for Alzheimer is being done in the last few decades. The aim of these studies is to find some method to ease the diagnosis of Alzheimers as early as possible. Such methods are a range of blood or CSF tests on one hand and several types of neuroimaging scans on the other. Many of the images coming both from laboratory and neuroimaging are very visual and illustrative. These images, accompanied by a short description, can perfectly explain the main results and usefulness of every biomarker. The objective of this book would be to summarize the most important studies made in this field. Few publications have systematically compiled results on this topic and only one as an atlas. Readers would be interested in this publication because it allows reviewing the current status of research by handily visualizing the results.

Clinical use of biomarkers for neurodegenerative disorders

Clinical use of biomarkers for neurodegenerative disorders Book
Author : Manuel Menéndez-González
Publisher : Frontiers Media SA
Release : 2014-12-03
ISBN : 2889194000
Language : En, Es, Fr & De

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Book Description :

The prevalence of neurodegenerative disorders is increasing dramatically and one of the major challenges today is the need of early and accurate diagnosis, the other is the need of more effective therapies -in turn the development of such therapies also requires early and accurate diagnosis-. The main hope for an earlier and more accurate diagnosis comes from the use of biomarkers. Much research is being done trying to solve the many interrogates related to the role of biomarkers in clinical practice, including the early diagnosis, differential diagnosis and follow-up of neurodegenerative disorders. This is a field where translational research is intense enough to make this topic interesting for basic researchers and clinicians. Indeed, the amount and quality of articles received in response to the call for contributions was very good. This eBook contains a good amount of high quality articles devoted to diverse techniques across several neurodegenerative disorders from different perspectives, including original reports, reviews, methods reports and opinion letters on biochemical biomarkers in biological fluids, neuroimaging techniques and multidimensional approaches linking clinical findings with biomarkers. The disorders covered are also diverse: Alzheimer’s disease, Frontotemporal Dementia, Dementia with Lewy Bodies, Huntington’s disease, Parkinson’s disease among others. As we can learn from articles in this Research Topic, biomarkers are allowing us to expand the knowledge on the biological and anatomical basis of neurodegenerative diseases and to implement diagnostic techniques in clinical practice and clinical trials.

Neurodegenerative Diseases

Neurodegenerative Diseases Book
Author : Daniela Galimberti,Elio Scarpini
Publisher : Springer
Release : 2018-03-15
ISBN : 3319729381
Language : En, Es, Fr & De

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Book Description :

This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson’s disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.

Biomarkers of Alzheimer s Disease The Present and the Future

Biomarkers of Alzheimer s Disease  The Present and the Future Book
Author : Sylvain Lehmann,Charlotte Elisabeth Teunissen
Publisher : Frontiers Media SA
Release : 2016-11-10
ISBN : 2889450414
Language : En, Es, Fr & De

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Book Description :

Alzheimer disease (AD) is a neurodegenerative disorder characterized by significant cognitive deficits, behavioral changes, sleep disorders and loss of functional autonomy. AD represents the main cause of dementia and has become a major public health issue. In addition, the number of patients suffering from AD is growing rapidly as the population ages worldwide. Memory impairment is usually the earliest clinical and core symptom of this disease. The diagnosis at a late clinical stage is relatively easy. However, a delay in the diagnosis is damageable for the handling of patients in terms of optimal medical and social care. The actual interest of the scientific head-ways is to optimize the diagnosis in prodromal stage of the disease and to propose personalized therapeutic solutions to individual patients. New revised AD diagnostic criteria include early alteration of cerebrospinal fluid (CSF) biomarkers: decrease of amyloïd peptides (Aβ42), and increase in tau and phosphorylated-tau (p-tau) protein concentration. This recognition of CSF biological biomarkers for the diagnosis of AD is a major step towards the “molecular” diagnosis and follow-up of the disease. Many issues are however still subject of debate. This e-book provides a comprehensive overview of the state of the art of fluid biomarkers for AD, e.g. which novel biomarkers should be implemented in clinical practice for diagnosis or for monitoring treatment or side effects, which ones are new for AD or related dementias or what is the potential of peripheral blood markers. Moreover, the e-Book provides practical guidelines how to optimally and efficiently develop and validate novel biomarker assays, and to document and control pre-analytical variation.

Alzheimer Disease The Changing View

Alzheimer Disease  The Changing View Book
Author : Robert Katzman,Katherine Bick
Publisher : Elsevier
Release : 2000-05-22
ISBN : 9780080527086
Language : En, Es, Fr & De

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Book Description :

This book details how "Alzheimer Disease" went from being an obscure neurologic diagnosis to a household word. The words of those responsible for this revolution are the heart of this book. Dr. Robert Katzman and Dr. Katherine Bick, leaders in Alzheimer research and policy making, interview the people responsible for this awakening of public consciousness about Alzheimer Disease from 1960 to 1980. They speak with the scientists, public health officials, government regulators, and concerned relatives and activists responsible for taking this neurodegenerative disease out of the "back wards" through the halls of Congress, and on to the front page. The reader will learn how the explosive increase in research funding and public awareness came about, how physicians and psychiatrists established diagnostic criteria, how drugs were developed that offer hope for sufferers, and how the Alzheimer's Association was born. * Written in the words of those responsible for the widespread recognition of this neurodegenerative disease * The authors are recognised as leaders in Alzheimer research and policy making

Global Clinical Trials for Alzheimer s Disease

Global Clinical Trials for Alzheimer   s Disease Book
Author : Michel Grothe,Jens Kurth,Harald Hampel,Bernd J. Krause,Stefan Teipel
Publisher : Elsevier Inc. Chapters
Release : 2013-08-28
ISBN : 0128070447
Language : En, Es, Fr & De

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Book Description :

In-vivo imaging markers of neuronal changes related to Alzheimer’s disease (AD) are ideally suited to be employed as diagnostic markers for early and differential diagnosis of AD as well as for the assessment of neurobiological effects of medical treatments in clinical trials. Novel molecular imaging techniques enable in-vivo detection of cerebral amyloid pathology, whereas magnetic resonance imaging (MRI)-based techniques, such as volumetric MRI and diffusion tensor imaging (DTI), provide structural lesion markers that allow tracking disease progression from preclinical through predementia to clinically manifest stages of AD. However, a widespread clinical use of these imaging biomarkers is hampered by considerable multi-centric variability related to differences in scanner hardware and acquisition protocols, but also by the lack of internationally agreed upon standards for analytic design and employed quantitative metrics. Several strategies for reducing multicenter variability in imaging measures have been proposed, including homogenization of the acquisition settings across scanner platforms, stringent quality assurance procedures, and artifact removal by means of post-acquisition image processing techniques. In addition, selection of appropriate statistical models to account for remaining multicenter variability in the data can further improve the accuracy and reproducibility of study results. The first projects for international standardization of image analysis methods and derived quantitative metrics have emerged recently for volumetric MRI measures. In contrast, the standardization and establishment of DTI-derived measures within a multicenter context are less well developed. Although molecular imaging techniques are already widely used in multicenter settings, sources of variability across sites and appropriate methods to reduce multicenter effects are still not explored in detail. Comparability of neuroimaging measures as AD biomarkers in worldwide clinical settings will finally depend on the establishment of internationally agreed upon standards for image acquisition, quality assurance, and employed quantitative metrics.

A Tattoo on my Brain

A Tattoo on my Brain Book
Author : Daniel Gibbs,Teresa H. Barker
Publisher : Cambridge University Press
Release : 2021-05-06
ISBN : 1108981062
Language : En, Es, Fr & De

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Book Description :

Dr Daniel Gibbs is one of 50 million people worldwide with an Alzheimer's disease diagnosis. Unlike most patients with Alzheimer's, however, Dr Gibbs worked as a neurologist for twenty-five years, caring for patients with the very disease now affecting him. Also unusual is that Dr Gibbs had begun to suspect he had Alzheimer's several years before any official diagnosis could be made. Forewarned by genetic testing showing he carried alleles that increased the risk of developing the disease, he noticed symptoms of mild cognitive impairment long before any tests would have alerted him. In this highly personal account, Dr Gibbs documents the effect his diagnosis has had on his life and explains his advocacy for improving early recognition of Alzheimer's. Weaving clinical knowledge from decades caring for dementia patients with his personal experience of the disease, this is an optimistic tale of one man's journey with early-stage Alzheimer's disease.

Alzheimer s Disease Theranostics

Alzheimer   s Disease Theranostics Book
Author : Magisetty Obulesu
Publisher : Academic Press
Release : 2019-01-20
ISBN : 0128167394
Language : En, Es, Fr & De

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Book Description :

Alzheimer’s Disease Theranostics discusses the latest information on recent theranostic avenues for both the diagnosis and treatment of Alzheimer’s patients. It presents the pros and cons of the probable mechanistic role of nanoparticles in crossing the blood-brain barrier and improving disease symptoms. Finally, it highlights the merits of existing maneuvers and suggests perspectives to aid in future developments. Despite the difficulty of drug delivery to the brain, there are some nanoparticulate platforms demonstrating promise in treating neurodegenerative disorders such as Alzheimer’s disease. Manifold theranostic maneuvers include antioxidants, natural bioactive compounds, gene therapy, and nanotechnological approaches, all of which are discussed in this important work. Examines various theranostic applications for the diagnosis and treatment of Alzheimer’s disease Features a comprehensive overview of nanoparticle therapeutics in the area and use of antioxidants Assesses the common challenges and lessons learned from blood-brain barrier challenges, viral vector approaches and mitochondria-targeted therapeutics

Emerging Technologies for Diagnosing Alzheimer s Disease

Emerging Technologies for Diagnosing Alzheimer s Disease Book
Author : Marianne Boenink,Harro van Lente,Ellen Moors
Publisher : Springer
Release : 2016-09-13
ISBN : 1137540974
Language : En, Es, Fr & De

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Book Description :

This book explores international biomedical research and development on the early diagnosis of Alzheimer's disease. It offers timely, multidisciplinary reflections on the social and ethical issues raised by promises of early diagnostics and asks under which conditions emerging diagnostic technologies can be considered a responsible innovation. The initial chapters in this edited volume provide an overview and a critical discussion of recent developments in biomedical research on Alzheimer's disease. Subsequent contributions explore the values at stake in current practices of dealing with Alzheimer's disease and dementia, both within and outside the biomedical domain. Novel diagnostic technologies for Alzheimer's disease emerge in a complex and shifting field, full of controversies. Innovating with care requires a precise mapping of how concepts, values and responsibilities are filled in through the confrontation of practices. In doing so, the volume offers a practice-based approach of responsible innovation that is also applicable to other fields of innovation.