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Dynemicin A Uncialamycin And Analogues

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Dynemicin A Uncialamycin and Analogues

Dynemicin A  Uncialamycin and Analogues Book
Author : Daniel Best,Mickael Jean,Pierre Van De Weghe
Publisher : Elsevier
Release : 2016-06-14
ISBN : 0081010869
Language : En, Es, Fr & De

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Book Description :

Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis. Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs. Presents two natural ènediynes with similar structures whose total syntheses have been accomplished Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity Describes the total syntheses of dynemicin A, the uncialamycine, as well as analogs by emphasizing the synthesis strategies adopted Features studies of the biological activities and data to bring out the structural elements of these essential compounds

Asymmetric Phase Transfer Catalysis

Asymmetric Phase Transfer Catalysis Book
Author : Keiji Maruoka
Publisher : John Wiley & Sons
Release : 2008-03-31
ISBN : 9783527318421
Language : En, Es, Fr & De

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Book Description :

Edited by the leading expert on the topic, this is the first book to present the latest developments in this exciting field. Alongside the theoretical aspects, the top contributors provide practical protocols to give readers additional important information otherwise unavailable. A must for every synthetic chemist in academia and industry.

Anticancer Agents from Natural Products Second Edition

Anticancer Agents from Natural Products  Second Edition Book
Author : Gordon M. Cragg,David G. I. Kingston,David J. Newman
Publisher : CRC Press
Release : 2011-10-10
ISBN : 1439813833
Language : En, Es, Fr & De

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Book Description :

The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry Book
Author : Atta-ur-Rahman
Publisher : Elsevier
Release : 2018-08-08
ISBN : 0444640592
Language : En, Es, Fr & De

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Book Description :

Studies in Natural Products Chemistry, Volume 58, covers the synthesis, testing and recording of the medicinal properties of natural products, providing cutting edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to rapidly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development in the pharmaceutical industry. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores

Cytotoxic Payloads for AntibodyDrug Conjugates

Cytotoxic Payloads for AntibodyDrug Conjugates Book
Author : David E Thurston,Paul J M Jackson
Publisher : Royal Society of Chemistry
Release : 2019-07-11
ISBN : 1788018451
Language : En, Es, Fr & De

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Book Description :

Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (KadcylaTM), brentuximab vedotin (AdcetrisTM), inotuzumab ozogamicin (BesponsaTM), gemtuzumab ozogamicin (MylotargTM) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages including the ability to select patients as likely responders based on the presence of antigen on the surface of their cancer cells and a wider therapeutic index, given that ADC targeting enables a more efficient delivery of cytotoxic agents to cancer cells than can be achieved by conventional chemotherapy, thus minimising systemic toxicity. Although there are many examples of antibodies that have been developed for this purpose, along with numerous linker technologies used to attach the cytotoxic agent to the antibody, there is presently a relatively small number of payload molecules in clinical use. The purpose of this book is to describe the variety of payloads used to date, along with a discussion of their advantages and disadvantages and to provide information on novel payloads at the research stage that may be used clinically in the future.

Biphasic Chemistry and The Solvent Case

Biphasic Chemistry and The Solvent Case Book
Author : Jean-Philippe Goddard,Max Malacria,Cyril Ollivier
Publisher : John Wiley & Sons
Release : 2020-02-05
ISBN : 1786305097
Language : En, Es, Fr & De

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Book Description :

Biphasic Chemistry and The Solvent Case examines recent improvements in reaction conditions, in order to affirm the role of chemistry in the sustainable field. This book shows that those who work within the chemistry industry support limits for the use of toxic or flammable solvents, since it reduces the purifications to simple filtrations. Thanks to commercial scavengers, solid phase syntheses are now available to all. Fluorine biphasic catalysis enables extremely efficient catalyst recycling and has a high applicability potential at the industrial level. This book also reviews the many studies that have shown that water is a solvent of choice for most synthetic reactions. Particular traits can be obtained and the effects on thermodynamics make it possible to operate at lower temperatures, thereby achieving energy savings. Finally the great diversity of application of the reactions without solvents is illustrated.

Microbes in Microbial Communities

Microbes in Microbial Communities Book
Author : Raghvendra Pratap Singh,Geetanjali Manchanda,Kaushik Bhattacharjee,Hovik Panosyan
Publisher : Springer
Release : 2021-12-16
ISBN : 9789811656163
Language : En, Es, Fr & De

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Book Description :

The book overviews the complex interactions amongst the microbes and their possible applications. Emphasis has been made to include a wide spectrum of experimental and theoretical contributions from eminent researchers in the field. Microbial communities are the assemblages of microorganisms of various species which live together in the same environment and continuously interact with each other. The microbial cells in communities display unique phenotypes that affect the survival and reproduction of other cells present around them. These phenotypes constitute the social adaptations that drive the interactions between microbial cells. The interactions, further determine the productivity, stability and the ability of community to resist the environmental perturbations. These microbial communities live with extremely competitive niche and fight for their survival and genetic persistence. But they frequently appear in niche with multifaceted and interactive webs rather than the planktonic nature. This can be within the same species or with different species, or even with diverse genera and families. It either a competitive winner community whereas the “weaker” strain goes extinct or a competitor that coexist with their metabolic secretory potentials or a separator that assigned their own community territorial niches. Sometimes, it can be neutral or tritagonist. These microbial associations within the microbiome provides the foundation for diverse forms of microbial ecology and determined the applied perspectives for agriculture, clinical and industrial sectors. This book will be useful to postgraduate students, researchers from academic as well as industry working in the field of microbial exploration with keen interest in survival factors and mechanism of their survival by various ecological and functional strategies.

Chemical Biology of Natural Products

Chemical Biology of Natural Products Book
Author : David J. Newman,Gordon M. Cragg,Paul Grothaus
Publisher : CRC Press
Release : 2017-09-22
ISBN : 1351643282
Language : En, Es, Fr & De

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Book Description :

Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing authors presenting current examples from their own work in order to exemplify key themes. Topics covered in the text include genome mining, heterologous expression, natural product synthesis, biosynthesis, glycosylation, chemical ecology, and therapeutic applications of natural products, both current and potential.

Building a Practical Information Security Program

Building a Practical Information Security Program Book
Author : Jason Andress,Mark Leary
Publisher : Syngress
Release : 2016-11-01
ISBN : 0128020881
Language : En, Es, Fr & De

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Book Description :

Building a Practical Information Security Program provides users with a strategic view on how to build an information security program that aligns with business objectives. The information provided enables both executive management and IT managers not only to validate existing security programs, but also to build new business-driven security programs. In addition, the subject matter supports aspiring security engineers to forge a career path to successfully manage a security program, thereby adding value and reducing risk to the business. Readers learn how to translate technical challenges into business requirements, understand when to "go big or go home," explore in-depth defense strategies, and review tactics on when to absorb risks. This book explains how to properly plan and implement an infosec program based on business strategy and results. Provides a roadmap on how to build a security program that will protect companies from intrusion Shows how to focus the security program on its essential mission and move past FUD (fear, uncertainty, and doubt) to provide business value Teaches how to build consensus with an effective business-focused program

Comprehensive Natural Products III

Comprehensive Natural Products III Book
Author : Anonim
Publisher : Elsevier
Release : 2020-07-22
ISBN : 0081026919
Language : En, Es, Fr & De

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Book Description :

Comprehensive Natural Products III, Third Edition, updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience

Catalytic Cascade Reactions

Catalytic Cascade Reactions Book
Author : Peng-Fei Xu,Wei Wang
Publisher : John Wiley & Sons
Release : 2013-11-11
ISBN : 1118016025
Language : En, Es, Fr & De

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Book Description :

Demonstrates the advantages of catalytic cascade reactions for synthesizing natural products and pharmaceuticals Riding the wave of green chemistry, catalytic cascade reactions have become one of the most active research areas in organic synthesis. During a cascade reaction, just one reaction solvent, one workup procedure, and one purification step are needed, thus significantly increasing synthetic efficiency. Featuring contributions from an international team of pioneers in the field, Catalytic Cascade Reactions demonstrates the versatility and application of these reactions for synthesizing valuable compounds. The book examines both organocatalysis and transition-metal catalysis reactions, bringing readers up to date with the latest discoveries and activities in all major areas of catalytic cascade reaction research. Catalytic Cascade Reactions begins with three chapters dedicated to organocatalytic cascade reactions, exploring amines, Brønsted acids, and the application of organocatalytic cascade reactions in natural product synthesis and drug discovery. Next, the book covers: Gold-catalyzed cascade reactions Cascade reactions catalyzed by ruthenium, iron, iridium, rhodium, and copper Palladium-catalyzed cascade reactions of alkenes, alkynes, and allenes Application of transition-metal catalyzed cascade reactions in natural product synthesis and drug discovery Engineering mono- and multifunctional nanocatalysts for cascade reactions Multiple-catalyst-promoted cascade reactions All chapters are thoroughly referenced, providing quick access to important original research findings and reviews so that readers can explore individual topics in greater depth. Drawing together and analyzing published findings scattered across the literature, this book provides a single source that encapsulates our current understanding of catalytic cascade processes. Moreover, it sets the stage for the development of new catalytic cascade reactions and their applications.

Classics in Total Synthesis

Classics in Total Synthesis Book
Author : K. C. Nicolaou,E. J. Sorensen
Publisher : John Wiley & Sons
Release : 1996-04-11
ISBN : 3527292314
Language : En, Es, Fr & De

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Book Description :

K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.

Molecules That Changed the World

Molecules That Changed the World Book
Author : K. C. Nicolaou,Tamsyn Montagnon
Publisher : Wiley-VCH
Release : 2008-03-17
ISBN : 9783527309832
Language : En, Es, Fr & De

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Book Description :

K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry Here, the best-selling author and renowned researcher, K. C. Nicolaou, presents around 40 natural products that all have an enormous impact on our everyday life. Printed in full color throughout with a host of pictures, this book is written in the author's very enjoyable and distinct style, such that each chapter is full of interesting and entertaining information on the facts, stories and people behind the scenes. Molecules covered span the healthy and useful, as well as the much-needed and extremely toxic, including Aspirin, urea, camphor, morphine, strychnine, penicillin, vitamin B12, Taxol, Brevetoxin and quinine. A veritable pleasure to read.

Computational Organic Chemistry

Computational Organic Chemistry Book
Author : Steven M. Bachrach
Publisher : John Wiley & Sons
Release : 2014-03-03
ISBN : 1118671228
Language : En, Es, Fr & De

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Book Description :

The Second Edition demonstrates how computational chemistry continues to shed new light on organic chemistry The Second Edition of author Steven Bachrach’s highly acclaimed Computational Organic Chemistry reflects the tremendous advances in computational methods since the publication of the First Edition, explaining how these advances have shaped our current understanding of organic chemistry. Readers familiar with the First Edition will discover new and revised material in all chapters, including new case studies and examples. There’s also a new chapter dedicated to computational enzymology that demonstrates how principles of quantum mechanics applied to organic reactions can be extended to biological systems. Computational Organic Chemistry covers a broad range of problems and challenges in organic chemistry where computational chemistry has played a significant role in developing new theories or where it has provided additional evidence to support experimentally derived insights. Readers do not have to be experts in quantum mechanics. The first chapter of the book introduces all of the major theoretical concepts and definitions of quantum mechanics followed by a chapter dedicated to computed spectral properties and structure identification. Next, the book covers: Fundamentals of organic chemistry Pericyclic reactions Diradicals and carbenes Organic reactions of anions Solution-phase organic chemistry Organic reaction dynamics The final chapter offers new computational approaches to understand enzymes. The book features interviews with preeminent computational chemists, underscoring the role of collaboration in developing new science. Three of these interviews are new to this edition. Readers interested in exploring individual topics in greater depth should turn to the book’s ancillary website www.comporgchem.com, which offers updates and supporting information. Plus, every cited article that is available in electronic form is listed with a link to the article.

Phenolic Compounds in Food

Phenolic Compounds in Food Book
Author : Leo M.L. Nollet,Janet Alejandra Gutierrez-Uribe
Publisher : CRC Press
Release : 2018-01-29
ISBN : 1351646478
Language : En, Es, Fr & De

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Book Description :

Phenolic compounds, one of the most widely distributed groups of secondary metabolites in plants, have received a lot of attention in the last few years since the consumption of vegetables and beverages with a high level of such compounds may reduce risks of the development of several diseases. This is partially due to their antioxidant power since other interactions with cell functions have been discovered. What’s more, phenolic compounds are involved in many functions in plants, such as sensorial properties, structure, pollination, resistance to pests and predators, germination, processes of seed, development, and reproduction. Phenolic compounds can be classified in different ways, ranging from simple molecules to highly polymerized compounds. Phenolic Compounds in Food: Characterization and Analysis deals with all aspects of phenolic compounds in food. In five sections, the 21 chapters of this book address the classification and occurrence of phenolic compounds in nature and foodstuffs; discuss all major aspects of analysis of phenolic compounds in foods, such as extraction, clean-up, separation, and detection; detail specific analysis methods of a number of classes of phenolic compounds, from simple molecules to complex compounds; describe the antioxidant power of phenolic compounds; and discuss specific analysis methods in different foodstuffs.

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Nucleic Acids as Gene Anticancer Drug Delivery Therapy Book
Author : Loutfy H. Madkour
Publisher : Academic Press
Release : 2019-08-27
ISBN : 0128197781
Language : En, Es, Fr & De

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Book Description :

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy

Natural and Synthetic Biomedical Polymers

Natural and Synthetic Biomedical Polymers Book
Author : Sangamesh Kumbar,Cato Laurencin,Meng Deng
Publisher : Newnes
Release : 2014-01-21
ISBN : 0123972906
Language : En, Es, Fr & De

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Book Description :

Polymers are important and attractive biomaterials for researchers and clinical applications due to the ease of tailoring their chemical, physical and biological properties for target devices. Due to this versatility they are rapidly replacing other classes of biomaterials such as ceramics or metals. As a result, the demand for biomedical polymers has grown exponentially and supports a diverse and highly monetized research community. Currently worth $1.2bn in 2009 (up from $650m in 2000), biomedical polymers are expected to achieve a CAGR of 9.8% until 2015, supporting a current research community of approximately 28,000+. Summarizing the main advances in biopolymer development of the last decades, this work systematically covers both the physical science and biomedical engineering of the multidisciplinary field. Coverage extends across synthesis, characterization, design consideration and biomedical applications. The work supports scientists researching the formulation of novel polymers with desirable physical, chemical, biological, biomechanical and degradation properties for specific targeted biomedical applications. Combines chemistry, biology and engineering for expert and appropriate integration of design and engineering of polymeric biomaterials Physical, chemical, biological, biomechanical and degradation properties alongside currently deployed clinical applications of specific biomaterials aids use as single source reference on field. 15+ case studies provides in-depth analysis of currently used polymeric biomaterials, aiding design considerations for the future

Lichen Biology

Lichen Biology Book
Author : Thomas H. Nash
Publisher : Cambridge University Press
Release : 2008-06-24
ISBN : 9780521692168
Language : En, Es, Fr & De

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Book Description :

Lichens are symbiotic organisms in which fungi and algae and/or cyanobacteria form an intimate biological union. This diverse group is found in almost all terrestrial habitats from the tropics to polar regions. In this second edition, four completely new chapters cover recent developments in the study of these fascinating organisms, including lichen genetics and sexual reproduction, stress physiology and symbiosis, and the carbon economy and environmental role of lichens. The whole text has been fully updated, with chapters covering anatomical, morphological and developmental aspects; the contribution of the unique secondary metabolites produced by lichens to medicine and the pharmaceutical industry; patterns of lichen photosynthesis and respiration in relation to different environmental conditions; the role of lichens in nitrogen fixation and mineral cycling; and the use of lichens as indicators of air pollution. This is a valuable reference for both students and researchers interested in lichenology.

Biosynthesis of Heterocycles

Biosynthesis of Heterocycles Book
Author : Patrizia Diana,Girolamo Cirrincione
Publisher : John Wiley & Sons
Release : 2015-02-09
ISBN : 1118028678
Language : En, Es, Fr & De

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Book Description :

This book describes biosynthetic methods to synthesize heterocyclic compounds, offering a guide for the development of new drugs based on natural products. The authors explain the role of natural products in chemistry and their formation along with important analytical methods and techniques for working with heterocycles. • Covers methods and techniques: isotopic labelling, enzymes and mutants, and pathway identification • Provides a thorough resource of information specifically on heterocyclic natural products and their practical biosynthetic relevance • Explains the role of natural products in chemistry and their formation • Discusses gene cluster identification and the use of biogenetic engineering in pharmaceutical application

Microbial Linear Plasmids

Microbial Linear Plasmids Book
Author : Friedhelm Meinhardt,Roland Klassen
Publisher : Springer Science & Business Media
Release : 2007-07-31
ISBN : 3540720251
Language : En, Es, Fr & De

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Book Description :

A book that constitutes the first attempt to comprehensively assemble current knowledge of different types of such elements, highlight recent developments in the field, and challenge the distinction between viruses and linear plasmids. Linear plasmids of microbes represent a heterogenous group of extrachromosomal genetic elements initially assumed to be rare and peculiar. However, we now know that they are fairly frequently occurring plasmids in bacterial and eukaryotic species. Viral strategies to avoid shortening of the linear molecules during replication imply a common ancestry.