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Drug Metabolism In Diseases

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Drug Metabolism in Diseases

Drug Metabolism in Diseases Book
Author : Wen Xie
Publisher : Academic Press
Release : 2016-09-12
ISBN : 0128029633
Language : En, Es, Fr & De

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Book Description :

Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. Written and edited by leaders in drug metabolism from academia and industry Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic

The Effect of Disease States on Drug Pharmacokinetics

The Effect of Disease States on Drug Pharmacokinetics Book
Author : American Pharmaceutical Association
Publisher : Unknown
Release : 1976
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Effect of Disease States on Drug Pharmacokinetics book written by American Pharmaceutical Association, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cytochrome P450 2E1 Its Role in Disease and Drug Metabolism

Cytochrome P450 2E1  Its Role in Disease and Drug Metabolism Book
Author : Aparajita Dey
Publisher : Springer Science & Business Media
Release : 2013-02-12
ISBN : 9400758812
Language : En, Es, Fr & De

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Book Description :

The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.

Nuclear Receptors in Drug Metabolism

Nuclear Receptors in Drug Metabolism Book
Author : Wen Xie
Publisher : John Wiley & Sons
Release : 2008-11-03
ISBN : 0470409053
Language : En, Es, Fr & De

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Book Description :

This book gives you an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development and equips you with the interdisciplinary understanding of these receptors and how they can be regulated. Pharmaceutical researchers will find this extremely useful in developing drugs for cancer, heart disease, and diabetes treatment. This comprehensive resource collects scattered materials into one handy, informative volume.

Introduction to Drug Metabolism

Introduction to Drug Metabolism Book
Author : G. Gordon Gibson,Paul Skett
Publisher : Springer
Release : 1986-01-01
ISBN : 9780412263903
Language : En, Es, Fr & De

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Book Description :

Although the scientific literature on drug metabolism is extensive, it suffers from the disadvantage that the material is diffuse and consists largely of specialist monographs dealing with particular aspects of the subject. In addi tion, although there are a few excellent texts on drug metabolism in print, these tend to be earlier publications and hence do not take into account the many recent advances in this area. Our motivations for writing this book therefore arose from the clear need for a recent and cohesive introductory text on this subject, specifically designed to cater for the needs of undergraduate and postgraduate students. Much of the subject matter in this text is derived from various courses on drug metabolism given at the University of Surrey and the University of Glasgow to basic science students in pharmacology, biochemistry, nutrition and nursing studies, to pre-clinical medical students and to under graduate and post-graduate students in toxicology. Therefore, it is our inten tion that this text will serve as a primer in drug metabolism to a variety of students in the life sciences taking courses in this subject. The term 'drug metabolism' in its broadest sense may be considered as the absorption, distribution, biotransformation and excretion of drugs. To cover all these facets of drug metabolism in a single text is a voluminous task and therefore we have focused primarily on the biotransformation aspects of the subject.

Drug Interactions in Infectious Diseases

Drug Interactions in Infectious Diseases Book
Author : Stephen C. Piscitelli,Keith A. Rodvold,Manjunath P. Pai
Publisher : Springer Science & Business Media
Release : 2011-09-08
ISBN : 9781617792137
Language : En, Es, Fr & De

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Book Description :

The revised and up-to-date third edition of Drug Interactions in Infectious Diseases delivers a text that will enhance your clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation. The third edition features five new chapters that cover material not addressed in previous editions. These new chapters describe interactions with a number of drug classes such as non-HIV antiviral, antimalarial, antiparasitic, antihelmintic, macrolide, azalide and ketolide agents. A novel chapter on probe cocktail studies has been included to highlight an important research tool for drug development. These chapters address material that cannot be retrieved easily in the medical literature. The highly acclaimed food-drug interactions as well as the study design and analysis chapters remain definitive references. The newly written drug-cytokine interaction highlights the need for our improved understanding of the complex interrelationship of acute infection, inflammation, and the risk of drug interactions. Informative tables on specific drug-drug interactions are provided throughout the chapters as a quick clinical resource. The Third Edition of Drug Interactions in Infectious Diseases is a distillation of relevant drug interactions associated with antimicrobials, infection, and inflammation. This concise review of the mechanisms and strategies to manage drug interactions should be valuable to all health care practitioners. Features • Definitive reference source of up-to-date information on antimicrobial drug interactions • Informative tables on the degree of interaction for specific antimicrobial agents • In-depth discussion of mechanisms and potential mechanistic pathways of interaction • New chapters on non-HIV antiviral, antimalarial, antiparasitic, and macrolide, azalide and ketolide agents • New chapter on probe-cocktail studies as a research tool to study drug-drug interactions • Inclusion of new antimicrobial agents and their associated drug interactions • First rate chapters on study design and analysis, and drug-food interactions • A fresh perspective on drug-cytokine interactions • Authoritative chapter on regulatory considerations of drug interactions during drug development

Xenosensor Regulation of Enzymes and Transporters in Drug Exposure and Disease

Xenosensor Regulation of Enzymes and Transporters in Drug Exposure and Disease Book
Author : Matthew David Merrell
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A large and varied array of xenobiotics (foreign chemicals) enters into our bodies every day. In order to prevent toxicity resulting from xenobiotic accumulation, the body has developed a complex and integrated network of enzymes and transporters to promote and control the metabolism and excretion of drugs and other compounds. Drug metabolizing enzymes are classified as oxidative (Phase I) or conjugative (Phase II), and generally result in increased hydrophilicity of their substrates. Drug transporters actively route xenobiotics into (Phase 0) or out of (Phase III) the cells. The expression of the proteins involved in drug metabolism and transport are coordinately regulated by xenosensing transcription factors, including the constitutive androstane receptor, the pregnane X receptor, the aryl hydrocarbon receptor, and Nrf2. Through the activation of these xenosensors, chemical exposure itself induces the processes which help to remove the xenobiotics from the body. The liver is the major organ of drug metabolism in the body. Chronic hepatic diseases impact the activity of xenosensors and the expression of their enzyme and transporter gene targets. Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease in the United States, affecting 20-30% of the populations. This profoundly underdiagnosed disease has significant effects on hepatic gene expression and may increase the risk of adverse drug reactions and xenobiotic toxicity in affected patients. This manuscript presents original research which contributes to our understanding of xenosensor function in the contexts of chemical exposure and liver disease. Manuscripts in this dissertation investigate 1) the induction profile and mechanisms of the experimental therapeutic agent oltipraz, 2) the xenosensor-regulated mechanisms of induction of the drug transporter ABCC3, 3) the impact of NAFLD on the expression of major drug metabolizing enzymes, and 4) the utility of altered drug disposition as a biomarker for NAFLD progression. The findings of these studies highlight the clinical importance of xenosensor activation and the potential pharmacological and toxicological consequences of hepatic disease.

New Applications of NMR in Drug Discovery and Development

New Applications of NMR in Drug Discovery and Development Book
Author : Leoncio Garrido,Nicolau Beckmann
Publisher : Royal Society of Chemistry
Release : 2013-07-18
ISBN : 1849737665
Language : En, Es, Fr & De

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Book Description :

This book presents a review of recent developments in NMR applications in pharmaceutical research. Consideration is given to consolidated and emerging techniques and methods in NMR, many of which are not widely applied but are likely to provide new opportunities for drug design. The first part of the book is dedicated to the description of NMR as a tool for the analysis of chemicals and interaction with targets. Particular emphasis is put on applications with unexploited potential for drug discovery and development. The next seven chapters describe NMR approaches to investigate in vivo models of interest in drug discovery and development, with the attention focused on anatomy, function, metabolism and molecular-cellular aspects. Finally, consideration is given to the application of in vivo NMR to the identification and characterization of biomarkers with the aim of monitoring the outcome of therapeutic intervention in selected human diseases, including the study of drug metabolism and toxicity. Aimed at NMR spectroscopists and pharmaceutical scientists, this title will be invaluable at putting NMR within context in its role in drug discovery and development. This resource will be essential reading for those both new and already active in these areas.

Proceedings of 3rd World Congress and Exhibition on Antibiotics and Antibiotic Resistance 2017

Proceedings of 3rd World Congress and Exhibition on Antibiotics and Antibiotic Resistance 2017 Book
Author : ConferenceSeries
Publisher : ConferenceSeries
Release : 2021-08-01
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

July 31-August 01, 2017 Milan, Italy Key Topics : Antibiotics, The Emergence of Antimicrobial Resistance, Antibiotic Resistance: Opportunities and Challenges, Different Types of Antibiotics and their Applications, Modern Antibiotics for Various Diseases and Infections, Antibiotic Prophylaxis, Antibiotics in Different Industries, Drug Discovery and Novel Delivery Technologies, Antibiotics for Emerging and Re-emerging Diseases, Micro Organisms in Recent Drug Discovery, Clinical Trials of Antibiotics, Antibiotics and Mechanism of Action, Antibiotic Regulatory Affairs, Advances in Antibiotic Treatment, Antibiotics for Cancer, Antibiotics: In Pregnancy and Lactation, Antibiotics for Diabetes, Antibiotics: Market Analysis & Business Opportunities, Entrepreneurs Investment Meet

Pharmacology of the Skin II

Pharmacology of the Skin II Book
Author : Anonim
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642740545
Language : En, Es, Fr & De

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Book Description :

The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin as in animal models, where they may be more relevant to human physiology and disease. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of aetiology and mechanism. For example, whilst the argument continued un resolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis retinoic acid, was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on aetiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as for the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.

Textbook of Therapeutics

Textbook of Therapeutics Book
Author : Richard A. Helms,David J. Quan
Publisher : Lippincott Williams & Wilkins
Release : 2006
ISBN : 0781757347
Language : En, Es, Fr & De

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Book Description :

The contributors to this volume deliver information on latest drug treatments and therapeutic approaches for a wide range of diseases and conditions. Coverage includes discussion of racial, ethnic, and gender differences in response to drugs and to biotechnical, pediatric and neonatal therapies.

Drug induced Diseases

Drug induced Diseases Book
Author : James E. Tisdale,Douglas A. Miller
Publisher : ASHP
Release : 2010
ISBN : 1585282057
Language : En, Es, Fr & De

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Book Description :

According to the authors, a drug-induced disease as an unintended effect of a drug, which results in mortality or morbidity with symptoms sufficient to prompt a patient to seek medical attention and/or require hospitalization. Since the first edition of this book was published in 2005, numerous drugs have been withdrawn from the market in the United States as a result of morbidity and/or mortality associated with drug-induced diseases. Despite best efforts to assure that all drugs are safe and effective, millions of patients each year develop drug-induced diseases. Every time a patient presents with a new disease or an exacerbation of an existing condition, someone needs to ask, "Could this be drug-related? Now in its second edition, this popular and essential comprehensive resource provides a detailed analysis of how to identify, prevent, and manage drug-induced diseases. Edited by James E. Tisdale and Douglas A. Miller, with contributions from experts distinguished in their respective specialties, Drug-Induced Diseases is organized logically and is easy to use for pharmacists, physicians, nurses, and pharmacy students alike. Inside you'll find: Chapters dedicated to each disease state. In-depth tables throughout each chapter. A new section on Drug-Induced dermatologic diseases. New drugs implicated as the cause of specific disease(s). The inclusion of the Levels of Evidence classification scheme for identifying drug-induced diseases. And much more.

Drug Metabolism Reviews

Drug Metabolism Reviews Book
Author : Anonim
Publisher : Unknown
Release : 1984
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Drug Metabolism Reviews book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cytochromes P450

Cytochromes P450 Book
Author : Patrick M Dansette
Publisher : Unknown
Release : 2021-06-30
ISBN : 9783036502564
Language : En, Es, Fr & De

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Book Description :

This book, "Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity", presents five papers on human cytochrome P450 (CYP) and P450 reductase, three reviews on the role of CYPs in humans and their use as biomarkers, six papers on CYPs in microorganisms, and one study on CYP in insects. The first paper reports the in silico modeling of human CYP3A4 access channels. The second uses structural methods to explain the mechanism-based inactivation of CYP3A4 by mibefradil, 6,7-dihydroxy-bergamottin, and azamulin. The third article compares electron transfer in CYP2C9 and CYP2C19 using structural and biochemical methods, and the fourth uses kinetic methods to study electron transfer to CYP2C8 allelic mutants. The fifth article characterizes electron transfer between the reductase and CYP using in silico and in vitro methods, focusing on the conformations of the reductase. Then, two reviews describe clinical implications in cardiology and oncology and the role of fatty acid metabolism in cardiology and skin diseases. The second review is on the potential use of circulating extracellular vesicles as biomarkers. Five papers analyze the CYPomes of diverse microorganisms: the Bacillus genus, Mycobacteria, the fungi Tremellomycetes, Cyanobacteria, and Streptomyces. The sixth focuses on a specific Mycobacterium CYP, CYP128, and its importance in M. tuberculosis. The subject of the last paper is CYP in Sogatella furcifera, a plant pest, and its resistance to the insecticide sulfoxaflor

Handbook of Drug Nutrient Interactions

Handbook of Drug Nutrient Interactions Book
Author : Joseph I. Boullata,Vincent T. Armenti
Publisher : Springer Science & Business Media
Release : 2004-04-17
ISBN : 1592597815
Language : En, Es, Fr & De

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Book Description :

Although there is agreat deal ofliterature regarding drug-nutrientinteractions (DNis ), there are limited sources of up-to-date comprehensive information. The Handbook of Drug-Nutrient Interactions admirably fills this gap. The editors, Dr. Joseph 1. Boullata and Dr. Vincent T. Armenti, ha ve a wealth of experience in this therapeutic ar ea and ha ve assembled a fine cadre of chapter authors who have individually contributed their high level of expertise. As treatment for many diseases becomes increasingly complex with multiple drug therapies scheduled at varying times, the need to identify clinically significant DNis is an essential part of medication management. This is a shared responsibility between health care professionals to interpret available data and individualize an approach to therapy that is compatible with the patient' s disease state, life stage, and dietary intake. Awareness ofthe significance of drug-food interactions is generally lacking. Although many texts contain lengthy lists of possible interactions, few data are provided for the clinician to gain an understanding of the mechanism of action of the interaction and subsequently apply the information to a particular patient or group of patients. For example, in the management of patients with HN -AIDS who are taking complex prescribed drug regimens, herbal products, and nutritional supplements, many of which are affected by dietary intake, careful attention to D Nls is a critic al component of therapy. Clinicians need to take account of not only the well-documented interactions between drugs and nutrients, but also the less obvious effects on drug-nutrient disposition and metabolism.

Drug Metabolism

Drug Metabolism Book
Author : Corina Ionescu,Mino R. Caira
Publisher : Springer Science & Business Media
Release : 2006-02-28
ISBN : 9781402041419
Language : En, Es, Fr & De

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Book Description :

Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.

Lipases and Phospholipases in Drug Development

Lipases and Phospholipases in Drug Development Book
Author : Günter Müller,Stefan Petry
Publisher : John Wiley & Sons
Release : 2006-03-06
ISBN : 3527605703
Language : En, Es, Fr & De

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Book Description :

Lipases and Phospholipases are key control elements in mammalian metabolism. They share many common features that set them apart from other metabolic enzyme classes, most importantly their association with biological membranes. Their potential as drug targets for the treatment of metabolic diseases is widely recognized, and the first lipase inhibitor drugs have been successfully introduced. Providing drug developers with a firm foundation for lipase-centered drug design, the editors of this volume have assembled experts from different scientific disciplines to create a comprehensive handbook for all pharmaceutical chemists, biochemists and physiologists working with lipases. The authors examine fundamental aspects of lipase function in vitro and in vivo, explaining how this knowledge may be used to develop lipase assays. They also treat the physiological roles of lipases in normal and disordered metabolism, as well as strategies to target lipases for the treatment of diabetes, obesity and related disorders. Additional topics include the application of phospholipases for liposome-based drug delivery and their use as diagnostic tools.

Biopharmaceutics and Clinical Pharmacokinetics

Biopharmaceutics and Clinical Pharmacokinetics Book
Author : Milo Gibaldi
Publisher : Unknown
Release : 1984
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biopharmaceutics and Clinical Pharmacokinetics book written by Milo Gibaldi, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug Interactions in Infectious Diseases

Drug Interactions in Infectious Diseases Book
Author : Stephen C. Piscitelli,Keith Rodvold
Publisher : Springer Science & Business Media
Release : 2007-10-28
ISBN : 1592599249
Language : En, Es, Fr & De

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Book Description :

Over the past 25 years, the world’s population has witnessed an explosion in kno- edge about infectious diseases. The global population is coming to the realization that diseases long recognized to cause substantial suffering, such as malaria, tuberculosis, schistosomiasis, and hepatitis, can be diagnosed and treated, and that transmission can be prevented using tools that are available, and which may be becoming increasingly affordable. The global population is recognizing that few infections are local: the travel of humans, other animals, insects, and food transport pathogens around the world, often with astonishing rapidity. New pathogens are appearing, either newly recognized or newly developing, such as severe acute respiratory syndrome (SARS), avian inf- enza, metapneumovirus, or hepatitis C, which are causing human morbidity and m- tality. Finally, there is growing fear that dangerous pathogens may be intentionally introduced into human populations by deranged individuals or terrorist organizations. The potential to use drugs or biologic agents to treat and prevent infectious diseases has increased dramatically over the past quarter century as we have learned more about the biology of many of these agents, and as we have developed techniques to discover new agents by high throughput screening programs and by sophisticated drug design and synthesis.