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Innovation in the Pharmaceutical Industry

Innovation in the Pharmaceutical Industry Book
Author : Takuji Hara
Publisher : Edward Elgar Publishing
Release : 2003-01-01
ISBN : 1843765667
Language : En, Es, Fr & De

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Book Description :

"Addressing a number of practical implications for the promotion of the pharmaceutical industry, this book will be of enormous interest to students, researchers and academics specializing in science and technology studies, and the management of technology and innovation. Practitioners, managers, and policy planners within the pharmaceutical industry will also deem this book invaluable."--BOOK JACKET.

Drug Discovery from Nature

Drug Discovery from Nature Book
Author : S. Grabley,R. Thiericke
Publisher : Springer Science & Business Media
Release : 1998-11-26
ISBN : 9783540648444
Language : En, Es, Fr & De

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Book Description :

This book is unique in covering the present status and future potential of natural products in drug discovery. It provides readers with recent information regarding the impact on drug discovery, development and strategies, technical and automation aspects, and methods based on biochemistry as well as molecular biology, highlighting compounds from natural sources. Special emphasis is placed on the various strategies to gain access to natural compounds and combinatorial approaches by making use of both synthetic and biological methods.

Comprehensive Analysis of Parasite Biology

Comprehensive Analysis of Parasite Biology Book
Author : Sylke M?ller,Rachel Cerdan,Ovidiu Radulescu,Paul M. Selzer
Publisher : John Wiley & Sons
Release : 2016-10-17
ISBN : 3527339043
Language : En, Es, Fr & De

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Book Description :

Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art "omics" technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.

Natural Product Chemistry for Drug Discovery

Natural Product Chemistry for Drug Discovery Book
Author : Antony D. Buss,Mark S. Butler,Royal Society of Chemistry (Great Britain)
Publisher : Royal Society of Chemistry
Release : 2010
ISBN : 0854041931
Language : En, Es, Fr & De

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Book Description :

This up-to-date summary of natural product chemistry in drug discovery will appeal to scientists, professionals, postgraduates and industrial chemists.

Neglected Tropical Diseases

Neglected Tropical Diseases Book
Author : David C. Swinney,Michael P. Pollastri
Publisher : John Wiley & Sons
Release : 2019-09-30
ISBN : 3527343040
Language : En, Es, Fr & De

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Book Description :

A drug discovery reference to the crippling tropical diseases that affect more than 1 billion people. Neglected Tropical Diseases is the first book of its kind to offer a guide that follows the World Health Organization?s list of neglected tropical diseases. The authors?all are experts on the topic?address the development of effective treatments for 12 crippling infectious diseases that affect almost 20% of the world?s popluation. The book includes information on the common approaches and the most important factors that lead to the development of new drugs for treating tropical diseases. Individual chapters review 12 neglected tropical diseases that are grouped by infectious agent, from viruses to bacteria to eukaryotic parasites. For each of these diseases, the book explains the unmet medical need and explores the current and potential drug discovery strategies. The book also includes information on potential drug compounds derived from natural products. This important book: -Ties together information from different sources for developing novel treatsments forneglected tropical diseases -Is aligned with WHO?s initiative to eradicate tropical diseases -Outlines current and potential drugs for treating tropical diseases -Provides a standard reference for the entire field Written for medicinal chemists, pharmaceutical chemists, pharmaceutical industry, virologists, parasitologists, and specialists on tropics medicine, Neglected Tropical Diseases offers an essential guide and a systematic reference for the development of successful treatments for 12 crippling infectious diseases.

Epigenetic Drug Discovery

Epigenetic Drug Discovery Book
Author : Wolfgang Sippl,Manfred Jung
Publisher : John Wiley & Sons
Release : 2019-03-25
ISBN : 3527343148
Language : En, Es, Fr & De

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Book Description :

This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease. Epigenetic Drug Discovery is an important resource for medicinal chemists, pharmaceutical researchers, biochemists, molecular biologists, and molecular geneticists.

Drug Discovery and Development

Drug Discovery and Development Book
Author : Ramarao Poduri
Publisher : Springer Nature
Release : 2021-05-13
ISBN : 9811555346
Language : En, Es, Fr & De

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Book Description :

Download Drug Discovery and Development book written by Ramarao Poduri, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug Discovery and Development Present and Future

Drug Discovery and Development   Present and Future Book
Author : Anonim
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Drug Discovery and Development Present and Future book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug Discovery Handbook

Drug Discovery Handbook Book
Author : Shayne Cox Gad
Publisher : John Wiley & Sons
Release : 2005-07-08
ISBN : 0471728772
Language : En, Es, Fr & De

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Book Description :

The Drug Discovery Handbook gives professionals a tool tofacilitate drug discovery by bringing together, for the first timein one resource, a compendium of methods and techniques that needto be considered when developing new drugs. This comprehensive, practical guide presents an explanation of thelatest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systemsbiology Summaries of how these techniques and methods are used todiscover new central nervous system agents, antiviral agents,respiratory drugs, oncology drugs, and more Specific approaches to drug discovery, including problems thatare encountered, solutions to these problems, and limitations ofvarious methods and techniques The thorough coverage and practical, scientifically validproblem-solving approach of Drug Discovery Handbook will serve asan invaluable aid in the complex task of developing new drugs.

Drug Discovery

Drug Discovery Book
Author : Hany El-Shemy
Publisher : BoD – Books on Demand
Release : 2013-01-23
ISBN : 9535109065
Language : En, Es, Fr & De

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Book Description :

Natural products are a constant source of potentially active compounds for the treatment of various disorders. The Middle East and tropical regions are believed to have the richest supplies of natural products in the world. Plant derived secondary metabolites have been used by humans to treat acute infections, health disorders and chronic illness for tens of thousands of years. Only during the last 100 years have natural products been largely replaced by synthetic drugs. Estimates of 200 000 natural products in plant species have been revised upward as mass spectrometry techniques have developed. For developing countries the identification and use of endogenous medicinal plants as cures against cancers has become attractive. Books on drug discovery will play vital role in the new era of disease treatment using natural products.

Structure based Drug Discovery

Structure based Drug Discovery Book
Author : R. E. Hubbard
Publisher : Royal Society of Chemistry
Release : 2006-01-01
ISBN : 0854043519
Language : En, Es, Fr & De

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Book Description :

A collection of methods to determine and analyse the 3-D structure of biomolecules. These methods have been enhanced to improve the speed and quality of drug discovery.

Comparative Genomics and Proteomics in Drug Discovery

Comparative Genomics and Proteomics in Drug Discovery Book
Author : John Parrington,Kevin Coward
Publisher : Taylor & Francis
Release : 2018-11-01
ISBN : 1134155158
Language : En, Es, Fr & De

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Book Description :

Comparative Genomics and Proteomics in Drug Discovery gives an overview of how emerging genomic and proteomic technologies are making significant contributions to global drug discovery programs, and in particular the key role that comparative genomics and proteomics play within this strategy. Each chapter is written by respected authorities, with hands-on experience, from both academic and pharmaceutical backgrounds.

Ectoparasites

Ectoparasites Book
Author : Charles Q. Meng,Ann E. Sluder
Publisher : John Wiley & Sons
Release : 2018-10-22
ISBN : 3527341684
Language : En, Es, Fr & De

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Book Description :

This first book specifically dedicated to ectoparasite drug discovery is unique in providing insights from the veterinary as well as the medical perspective, covering research from both industry and academia while paving the way for new synergies between the two research communities. Edited by a team combining 80 years of experience in academic research and industrial antiparasitic drug discovery, this volume of Drug Discovery in Infectious Diseases summarizes current knowledge in this rapidly expanding field. Comprehensive yet concise, this ready reference blends solid background information on ectoparasite biology with the very latest methods in ectoparasite drug discovery. Three major parts cover current ectoparasite control strategies and the threat of drug resistance, screening and drug evaluation, and the new isoxazoline class of ectoparasiticides. The future potential of mechanism-based approaches for repellents and parasiticides is thoroughly discussed, as are strategies for vaccines against ectoparasites, making the book ideal for parasitologists in academia as well as researchers working in the pharmaceutical industry.

Predictive Approaches in Drug Discovery and Development

Predictive Approaches in Drug Discovery and Development Book
Author : J. Andrew Williams,Richard Lalonde,Jeffrey R. Koup,David D. Christ
Publisher : John Wiley & Sons
Release : 2012-04-10
ISBN : 0470170832
Language : En, Es, Fr & De

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Book Description :

Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers. Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.

Computational Medicinal Chemistry for Drug Discovery

Computational Medicinal Chemistry for Drug Discovery Book
Author : Patrick Bultinck,Hans De Winter,Wilfried Langenaeker,Jan P. Tollenare
Publisher : CRC Press
Release : 2003-12-17
ISBN : 9780203913390
Language : En, Es, Fr & De

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Book Description :

Observing computational chemistry's proven value to the introduction of new medicines, this reference offers the techniques most frequently utilized by industry and academia for ligand design. Featuring contributions from more than fifty pre-eminent scientists, Computational Medicinal Chemistry for Drug Discovery surveys molecular structure computa

Botanical Leads for Drug Discovery

Botanical Leads for Drug Discovery Book
Author : Bikarma Singh
Publisher : Springer Nature
Release : 2020-10-05
ISBN : 9811559171
Language : En, Es, Fr & De

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Book Description :

Active botanical ingredients are a prime requirement for herbal formulations and discovering a drug is all about integration of science disciplines. In recent decades there has been a growing interest in treating wounds and diseases using traditional remedies based on local herbs, combined with chemical advances. Although this has led to the development of new bioactive ingredients from plants, there has been little success in terms of clinical trials and post-marketing studies to comply with FDA guidelines. Plants have been used as a source of medicine throughout history and continue to serve as the basis for many pharmaceuticals used today. However, despite the modern pharmaceutical industry being founded on botanical medicine, synthetic approaches to drug discovery have now become standard. Science-driven translational discovery and botanical development has created a new reality, leading to enormous changes in strategies, technologies and the disciplines involved, which have been embraced by the pharmaceutical and biotech industries. This book gathers scientific expertise and traditional knowledge to promote the discovery and development of new formulations and drugs based on active ingredients and to provide guidance on taking these to clinical trials. It discusses major topics, such as how the phytochemical composition of many plants has changed over time due to factors like cultivation, which can have both positive and negative effects on the levels of bioactive compounds. It also explores the importance of plants as a valuable source of therapeutic compounds as a result of their vast biosynthetic capacity, and classifies them according to their intended use, safety and regulatory status. Further, the book offers insights into the regulatory aspects of botanical products, which is an important issue when considering standardization and quality assessment, and also examines the commercial aspects of plant-derived medications and their proven role in the treatment of chronic diseases such as heart disease, high blood pressure, pain, asthma, and other associated conditions. Given its scope, this book is a valuable tool for botanists, natural product chemists, pharmacologists and microbiologists involved in the study of phytochemicals for drug discovery.

Applied Biophysics for Drug Discovery

Applied Biophysics for Drug Discovery Book
Author : Donald Huddler,Edward R. Zartler
Publisher : John Wiley & Sons
Release : 2017-10-02
ISBN : 111909948X
Language : En, Es, Fr & De

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Book Description :

13.2.1 Protein Dynamics of SA WT and S1 Mutant DHFR in Apo and Bound States

Drug Discovery and Evaluation Safety and Pharmacokinetic Assays

Drug Discovery and Evaluation  Safety and Pharmacokinetic Assays Book
Author : H. Gerhard Vogel,Jochen Maas,Franz J. Hock,Dieter Mayer
Publisher : Springer
Release : 2013-02-27
ISBN : 9783642252396
Language : En, Es, Fr & De

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Book Description :

-A landmark in the continuously changing world of drugs -Essential reading for scientists and managers in the pharmaceutical industry involved in drug finding, drug development and decision making in the development process -Of use for government institutions and committees working on official guidelines for drug evaluation worldwide

3D Cell Based Biosensors in Drug Discovery Programs

3D Cell Based Biosensors in Drug Discovery Programs Book
Author : William S. Kisaalita
Publisher : CRC Press
Release : 2010-06-22
ISBN : 1420073508
Language : En, Es, Fr & De

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Book Description :

Advances in genomics and combinatorial chemistry during the past two decades inspired innovative technologies and changes in the discovery and pre-clinical development paradigm with the goal of accelerating the process of bringing therapeutic drugs to market. Written by William Kisaalita, one of the foremost experts in this field, 3D Cell-Based Bio

Drug Discovery

Drug Discovery Book
Author : Jie Jack Li,E. J. Corey
Publisher : John Wiley & Sons
Release : 2013-04-03
ISBN : 111835446X
Language : En, Es, Fr & De

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Book Description :

Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as: Target identification and validation Drug metabolism and pharmacokinetics Central nervous system drugs In vitro and in vivo assays Cardiovascular drugs Cancer drugs Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field. Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.