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Drug Discovery from Nature

Drug Discovery from Nature Book
Author : S. Grabley,R. Thiericke
Publisher : Springer Science & Business Media
Release : 1998-11-26
ISBN : 9783540648444
Language : En, Es, Fr & De

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Book Description :

This book is unique in covering the present status and future potential of natural products in drug discovery. It provides readers with recent information regarding the impact on drug discovery, development and strategies, technical and automation aspects, and methods based on biochemistry as well as molecular biology, highlighting compounds from natural sources. Special emphasis is placed on the various strategies to gain access to natural compounds and combinatorial approaches by making use of both synthetic and biological methods.

Basic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development Book
Author : Benjamin Blass
Publisher : Elsevier
Release : 2015-04-24
ISBN : 012411525X
Language : En, Es, Fr & De

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Book Description :

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property." Provides a clear explanation of how the pharmaceutical industry works Explains the complete drug discovery process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual propertyIdeal for anyone interested in learning about the drug discovery process and those contemplating careers in the industry Explains the transition process from academia or other industries

The Science and Business of Drug Discovery

The Science and Business of Drug Discovery Book
Author : Edward D. Zanders
Publisher : Springer Nature
Release : 2020-12-11
ISBN : 3030578143
Language : En, Es, Fr & De

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Book Description :

The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the twenty chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: Different types of drugs: from small molecules to stem cells Background to chemistry of small and large molecules Historical background to drug discovery, pharmacology and biotechnology The drug discovery pipeline: from target discovery to marketed medicine Commercial aspects of drug discovery Challenges to the biopharmaceutical industry and its responses Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators

Drug Discovery

Drug Discovery Book
Author : Tamas Bartfai,Graham V. Lees
Publisher : Academic Press
Release : 2010-07-26
ISBN : 0080919235
Language : En, Es, Fr & De

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Book Description :

Everyone expects something from the drug industry. Physicians and patients, investors, regulators and administrators all have an active interest. Everyone wants to know what makes drugs ‘work’ medically and economically. Why are drugs so expensive? Is it the drug companies or investors who demand high profits? What governs the pharmacoeconomics? Why are so few diseases treatable? This book opens the windows and doors of the industry telling the story of drug development by using real stories from inside the process. * Co-written by Graham Lees and Tamas Bartfai who has been involved in the development of drugs taken by more that 20 million people every day * Opens the windows and doors of the most regulated industry in the world, the pharmaceutical industry * Tells the story of drug development by using real examples based on current research and events * Provides an objective, lucid account of the successes and failures, shortcomings and constraints of the pharmaceutical and biotech industries * Gives insights into the development of new drugs to combat multiple conditions including cancer and pain * Balanced, unbiased account of how better to translate basic science into drug discovery

Macrocycles in Drug Discovery

Macrocycles in Drug Discovery Book
Author : Jeremy I Levin
Publisher : Royal Society of Chemistry
Release : 2014-10-16
ISBN : 1849737010
Language : En, Es, Fr & De

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Book Description :

This book reviews macrocycles in drug discovery, both those of natural origin and semi-synthetic derivatives of natural products, and those designed and synthesized based on principles of medicinal chemistry. The medicinal chemistry of macrocyclic natural products is interesting in itself, but lessons learned from these compounds, in terms of the relationship between structure and desirable physicochemical properties, are now informing the design of fully synthetic macrocyclic drug candidates against a variety of targets including kinases, ATPases, proteases, GPCRs and others. Furthermore, as more non-classical drug targets, such as protein-protein interactions, are pursued in the pharmaceutical industry, macrocyclic molecules are generating increasing interest as they offer a way to provide drug-protein interactions that cover a larger surface area than traditional small molecules. A variety of macrocycles have become important drugs or have been identified as leads to marketed drugs. This text will discuss these compounds, their pharmacology and synthesis, in the context of their broad chemotype as compounds composed of large rings. Providing a wide reaching review of this important area in a single volume, this book will be of interest to biochemists, pharmaceutical scientists and medicinal chemists working in industry or academia.

Chronicles of Drug Discovery

Chronicles of Drug Discovery Book
Author : Jasjit S. Bindra,Daniel Lednicer
Publisher : American Chemical Society
Release : 1993
ISBN : 9780841225237
Language : En, Es, Fr & De

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Book Description :

Offers a unique insight into the drug discovery process through informal histories presented by the drugs' inventor. A compilation of accounts describing the events leading from the initial discovery to successful introduction on the market of fourteen important new drugs, including RU 486 (mifepristone) and taxol. Many chapters outline in detail the chemical/biological rationale which led to the discovery. Includes drugs with a wide selection of therapeutic indications. Presents a broad range of development strategies.

Drug Discovery

Drug Discovery Book
Author : Hany El-Shemy
Publisher : BoD – Books on Demand
Release : 2013-01-23
ISBN : 9535109065
Language : En, Es, Fr & De

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Book Description :

Natural products are a constant source of potentially active compounds for the treatment of various disorders. The Middle East and tropical regions are believed to have the richest supplies of natural products in the world. Plant derived secondary metabolites have been used by humans to treat acute infections, health disorders and chronic illness for tens of thousands of years. Only during the last 100 years have natural products been largely replaced by synthetic drugs. Estimates of 200 000 natural products in plant species have been revised upward as mass spectrometry techniques have developed. For developing countries the identification and use of endogenous medicinal plants as cures against cancers has become attractive. Books on drug discovery will play vital role in the new era of disease treatment using natural products.

Optimization in Drug Discovery

Optimization in Drug Discovery Book
Author : Zhengyin Yan,Gary Caldwell
Publisher : Springer Science & Business Media
Release : 2004
ISBN : 1592598005
Language : En, Es, Fr & De

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Book Description :

Recent reports of drug attrition rates have revealed that a significant number of drug candidates fail in the later stage of clinical development due to absorption, distribution, metabolism, elimination and toxicity issues. Lead optimization in drug discovery, a process of attempting to uncover and correct these defects, is highly beneficial in lowering the cost and time to develop therapeutic drugs by reducing drug candidate failures in development. This book provides the assays utilized in drug discovery to rapidly screen for compounds with favorable drug-like properties. A total of 25 chapters, contributed by many experts in the field, cover a wide spectrum of subjects including physicochemical properties, absorption, plasma binding, metabolism, drug interactions, and toxicity, making this an essential book for all pharmacologists and pharmaceutical scientists.

Drug Discovery and Development

Drug Discovery and Development Book
Author : Omboon Vallisuta,Suleiman Olimat
Publisher : BoD – Books on Demand
Release : 2015-06-03
ISBN : 9535121286
Language : En, Es, Fr & De

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Book Description :

It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.

Drug Discovery

Drug Discovery Book
Author : Jie Jack Li,E. J. Corey
Publisher : John Wiley & Sons
Release : 2013-04-03
ISBN : 111835446X
Language : En, Es, Fr & De

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Book Description :

Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as: Target identification and validation Drug metabolism and pharmacokinetics Central nervous system drugs In vitro and in vivo assays Cardiovascular drugs Cancer drugs Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field. Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.

Applied Biophysics for Drug Discovery

Applied Biophysics for Drug Discovery Book
Author : Donald Huddler,Edward R. Zartler
Publisher : John Wiley & Sons
Release : 2017-10-02
ISBN : 111909948X
Language : En, Es, Fr & De

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Book Description :

13.2.1 Protein Dynamics of SA WT and S1 Mutant DHFR in Apo and Bound States

Modern Methods of Drug Discovery

Modern Methods of Drug Discovery Book
Author : Alexander Hillisch,Rolf Hilgenfeld
Publisher : Springer Science & Business Media
Release : 2002-12-11
ISBN : 9783764360818
Language : En, Es, Fr & De

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Book Description :

Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.

Natural Product Chemistry for Drug Discovery

Natural Product Chemistry for Drug Discovery Book
Author : Antony D. Buss,Mark S. Butler,Royal Society of Chemistry (Great Britain)
Publisher : Royal Society of Chemistry
Release : 2010
ISBN : 0854041931
Language : En, Es, Fr & De

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Book Description :

This up-to-date summary of natural product chemistry in drug discovery will appeal to scientists, professionals, postgraduates and industrial chemists.

Drug Discovery and Development

Drug Discovery and Development Book
Author : H. P. Rang,Daniel Vasella
Publisher : Churchill Livingstone
Release : 2006
ISBN :
Language : En, Es, Fr & De

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Book Description :

'Drug Discovery and Development' describes the huge complexities involved in bringing a drug to market and how new molecular understanding and techniques can make the process more targeted and successful.

Drug Discovery and Clinical Research

Drug Discovery and Clinical Research Book
Author : SK Gupta
Publisher : JP Medical Ltd
Release : 2011-06-01
ISBN : 9350252724
Language : En, Es, Fr & De

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Book Description :

The Drug Discovery and Clinical Research bandwagon has been joined by scientists and researchers from all fields including basic sciences, medical sciences, biophysicists, biotechnologists, statisticians, regulatory officials and many more. The joint effort and contribution from all is translating into the fast development of this multi-faceted field. At the same time, it has become challenging for all stakeholders to keep abreast with the explosion in information. The race for the finish-line leaves very little time for the researchers to update themselves and keep tabs on the latest developments in the industry. To meet these challenges, this book entitled Drug Discovery and Clinical Research has been compiled. All chapters have been written by stalwarts of the field who have their finger on the pulse of the industry. The aim of the book is to provide succinctly within one cover, an update on all aspects of this wide area. Although each of the chapter dealt here starting from drug discovery and development, clinical development, bioethics, medical devices, pharmacovigilance, data management, safety monitoring, patient recruitment, etc. are topics for full-fledged book in themselves, an effort has been made via this book to provide a bird’s eye view to readers and help them to keep abreast with the latest development despite constraints of time. It is hoped that the book will contribute to the growth of readers, which should translate into drug discovery and clinical research industry’s growth.

Drug Discovery and Evaluation Methods in Clinical Pharmacology

Drug Discovery and Evaluation  Methods in Clinical Pharmacology Book
Author : H.Gerhard Vogel,Jochen Maas,Alexander Gebauer
Publisher : Springer Science & Business Media
Release : 2010-12-15
ISBN : 3540898905
Language : En, Es, Fr & De

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Book Description :

Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".

Translational Medicine

Translational Medicine Book
Author : Robert A. Meyers
Publisher : John Wiley & Sons
Release : 2018-07-16
ISBN : 3527336591
Language : En, Es, Fr & De

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Book Description :

This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of compounds interacting with these targets. The rest of book covers the whole downstream pipeline after the identification of lead compounds, such as bioavailability issues, identification of appropriate drug delivery venues, production and scaling issues and preclinical trials. As has been the case with other works in the encyclopedia, the book is made up of long, comprehensive and authoritative chapters, written by outstanding researchers in the field.

Computational Medicinal Chemistry for Drug Discovery

Computational Medicinal Chemistry for Drug Discovery Book
Author : Patrick Bultinck,Hans De Winter,Wilfried Langenaeker,Jan P. Tollenare
Publisher : CRC Press
Release : 2003-12-17
ISBN : 9780203913390
Language : En, Es, Fr & De

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Book Description :

Observing computational chemistry's proven value to the introduction of new medicines, this reference offers the techniques most frequently utilized by industry and academia for ligand design. Featuring contributions from more than fifty pre-eminent scientists, Computational Medicinal Chemistry for Drug Discovery surveys molecular structure computa

Natural Products

Natural Products Book
Author : Lixin Zhang,Arnold L. Demain
Publisher : Springer Science & Business Media
Release : 2007-11-17
ISBN : 1592599761
Language : En, Es, Fr & De

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Book Description :

A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.

Target Discovery and Validation

Target Discovery and Validation Book
Author : Alleyn T. Plowright
Publisher : John Wiley & Sons
Release : 2019-12-31
ISBN : 3527345299
Language : En, Es, Fr & De

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Book Description :

The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research. This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume. It also includes numerous practical examples.