Skip to main content

Drug Discovery

In Order to Read Online or Download Drug Discovery Full eBooks in PDF, EPUB, Tuebl and Mobi you need to create a Free account. Get any books you like and read everywhere you want. Fast Download Speed ~ Commercial & Ad Free. We cannot guarantee that every book is in the library!

Drug Discovery Handbook

Drug Discovery Handbook Book
Author : Shayne C. Gad
Publisher : Wiley-Interscience
Release : 2005-07-11
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

THE FIRST COMPREHENSIVE GUIDE TO THE METHODS AND TECHNIQUES OF DRUG DISCOVERY The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs. This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systems biology Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more Specific approaches to drug discovery, including problems that are encountered, solutions to these problems, and limitations of various methods and techniques The thorough coverage and practical, scientifically valid problem-solving approach of Drug Discovery Handbook will serve as an invaluable aid in the complex task of developing new drugs.

Drug Discovery and Development for Alzheimer s Disease 2000

Drug Discovery and Development for Alzheimer s Disease  2000 Book
Author : Howard M. Fillit, MD,Alan W. O'Connell, PhD
Publisher : Springer Publishing Company
Release : 2002-01-03
ISBN : 9780826115348
Language : En, Es, Fr & De

GET BOOK

Book Description :

This prestigious volume presents the findings of an international group of academic and biotechnological researchers. Topics range from early detection programs focusing on genetic factors, novel probes for detecting B-amyloid in the living brain, and the use of telephonic screening and MRI's to the diversity of therapeutic areas such as antioxidants, estrogen agonists and various anti-B-amyloid and anti-tangle approaches. The volume is still an indispensable resource for the psychogeriatrician, psychiatrist, clinical investigator, and neurobiologist, and a must for medical libraries.

Membrane Transporters in Drug Discovery and Development

Membrane Transporters in Drug Discovery and Development Book
Author : Qing Yan
Publisher : Humana
Release : 2010-04-26
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

This text provides practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development.

Natural Product Chemistry for Drug Discovery

Natural Product Chemistry for Drug Discovery Book
Author : Antony D. Buss,Mark S. Butler,Royal Society of Chemistry (Great Britain)
Publisher : Royal Society of Chemistry
Release : 2010
ISBN : 0854041931
Language : En, Es, Fr & De

GET BOOK

Book Description :

This up-to-date summary of natural product chemistry in drug discovery will appeal to scientists, professionals, postgraduates and industrial chemists.

Drug Discovery and Evaluation

Drug Discovery and Evaluation Book
Author : H. Gerhard Vogel,Jochen Maas,Franz Jakob Hock,Dieter Mayer
Publisher : Springer Science & Business Media
Release : 2006
ISBN : 3540256385
Language : En, Es, Fr & De

GET BOOK

Book Description :

This book is a landmark in the continuously changing world of drugs. It is essential reading for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.

Target Validation in Drug Discovery

Target Validation in Drug Discovery Book
Author : Brian W. Metcalf,Susan Dillon
Publisher : Elsevier
Release : 2011-04-28
ISBN : 9780080465975
Language : En, Es, Fr & De

GET BOOK

Book Description :

This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

Drug Discovery for Leishmaniasis

Drug Discovery for Leishmaniasis Book
Author : Carmen Gil
Publisher : Royal Society of Chemistry
Release : 2017-11-02
ISBN : 1782628894
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Drug Discovery for Leishmaniasis book written by Carmen Gil, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Synthetic Methods in Drug Discovery

Synthetic Methods in Drug Discovery Book
Author : David C Blakemore,Paul M Doyle,Yvette M Fobian
Publisher : Royal Society of Chemistry
Release : 2016-07-15
ISBN : 178262791X
Language : En, Es, Fr & De

GET BOOK

Book Description :

Building on key reactions presented in Volume 1, Synthetic Methods in Drug Discovery Volume 2 covers a range of important reaction types including organometallic chemistry, fluorination approaches and asymmetric methods as well as new and exciting areas such as Csp2-Csp3 couplings, catalytic amide bond forming reactions, hydrogen borrowing chemistry and methods to access novel motifs and monomers. This book provides both academic and industrial perspectives on key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Moreover, key opportunities in expanding chemical space are presented, including the increasingly important syntheses that introduce three-dimensional molecular shape. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.

Real World Drug Discovery

Real World Drug Discovery Book
Author : Robert M. Rydzewski
Publisher : Elsevier
Release : 2010-07-07
ISBN : 9780080914886
Language : En, Es, Fr & De

GET BOOK

Book Description :

Drug discovery increasingly requires a common understanding by researchers of the many and diverse factors that go into the making of new medicines. The scientist entering the field will immediately face important issues for which his education may not have prepared him: project teams, patent law, consultants, target product profiles, industry trends, Gantt charts, target validation, pharmacokinetics, proteomics, phenotype assays, biomarkers, and many other unfamiliar topics for which a basic understanding must somehow be obtained. Even the more experienced scientist can find it frustratingly difficult to get an overview of the many factors involved in modern drug discovery and often only after years of exploring does a whole and integrated picture emerge in the mind of the researcher. Real World Drug Discovery: A Chemist’s Guide to Biotech and Pharmaceutical Research presents this kind of map of the landscape of drug discovery. In a single, readable volume it outlines processes and explains essential concepts and terms for the recent science graduate wondering what to expect in pharma or biotech, the medicinal chemist seeking a broader and more timely understanding of the industry, or the contractor or collaborator whose understanding of the commercial drug discovery process could increase the value of his contribution to it. Interviews with well-known experts in many of the fields involved, giving insightful comments from authorities on many of the sub-disciplines important to cutting edge drug discovery. Helpful suggestions gleaned from years of experience in biotech and pharma, which represents a repository drug discovery "lore" not previously available in any book. "Periodic Table of Drugs" listing current top-selling drugs arranged by target and laid out so that structural similarities and differences are plain and clear. Extensive use of diagrams to illustrate concepts like biotech startup models, preteomic profiling for target identification, Gantt charts for project planning, etc.

Fragment Based Drug Discovery

Fragment Based Drug Discovery Book
Author : Edward R. Zartler,Michael Shapiro
Publisher : John Wiley & Sons
Release : 2008-11-20
ISBN : 0470721561
Language : En, Es, Fr & De

GET BOOK

Book Description :

Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery. Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical tips, and contributions from industry. Topics covered include: an introduction to fragment based drug discovery, why using fragments is a more efficient process than predominant models, and what it means to have a successful FBDD effort. setting up an FBDD project library building and production NMR in fragment screening and follow up application of protein-ligand NOE matching to the rapid evaluation of fragment binding poses target immobilized NMR screening: validation and extension to membrane proteins in situ fragment-based medicinal chemistry: screening by mass spectrometry computational approaches to fragment and substructure discovery and evaluation virtual fragment scanning: current trends, applications and web based tools fragment-based lead discovery using covalent capture methods case study from industry: the identification of high affinity beta-secretase inhibitors using fragment-based lead generation With contributions from industry experts who have successfully set up an industrial fragment-based research program, Fragment-Based Drug Discovery: A Practical Approach offers essential advice to anyone embarking on drug discovery using fragments and those looking for a new approach to screening for drugs.

Botanical Leads for Drug Discovery

Botanical Leads for Drug Discovery Book
Author : Bikarma Singh
Publisher : Springer Nature
Release : 2020-10-05
ISBN : 9811559171
Language : En, Es, Fr & De

GET BOOK

Book Description :

Active botanical ingredients are a prime requirement for herbal formulations and discovering a drug is all about integration of science disciplines. In recent decades there has been a growing interest in treating wounds and diseases using traditional remedies based on local herbs, combined with chemical advances. Although this has led to the development of new bioactive ingredients from plants, there has been little success in terms of clinical trials and post-marketing studies to comply with FDA guidelines. Plants have been used as a source of medicine throughout history and continue to serve as the basis for many pharmaceuticals used today. However, despite the modern pharmaceutical industry being founded on botanical medicine, synthetic approaches to drug discovery have now become standard. Science-driven translational discovery and botanical development has created a new reality, leading to enormous changes in strategies, technologies and the disciplines involved, which have been embraced by the pharmaceutical and biotech industries. This book gathers scientific expertise and traditional knowledge to promote the discovery and development of new formulations and drugs based on active ingredients and to provide guidance on taking these to clinical trials. It discusses major topics, such as how the phytochemical composition of many plants has changed over time due to factors like cultivation, which can have both positive and negative effects on the levels of bioactive compounds. It also explores the importance of plants as a valuable source of therapeutic compounds as a result of their vast biosynthetic capacity, and classifies them according to their intended use, safety and regulatory status. Further, the book offers insights into the regulatory aspects of botanical products, which is an important issue when considering standardization and quality assessment, and also examines the commercial aspects of plant-derived medications and their proven role in the treatment of chronic diseases such as heart disease, high blood pressure, pain, asthma, and other associated conditions. Given its scope, this book is a valuable tool for botanists, natural product chemists, pharmacologists and microbiologists involved in the study of phytochemicals for drug discovery.

Epigenetic Drug Discovery

Epigenetic Drug Discovery Book
Author : Wolfgang Sippl,Manfred Jung
Publisher : John Wiley & Sons
Release : 2018-12-10
ISBN : 3527809287
Language : En, Es, Fr & De

GET BOOK

Book Description :

This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease. Epigenetic Drug Discovery is an important resource for medicinal chemists, pharmaceutical researchers, biochemists, molecular biologists, and molecular geneticists.

Computational and Structural Approaches to Drug Discovery

Computational and Structural Approaches to Drug Discovery Book
Author : Robert Stroud,Janet Finer-Moore
Publisher : Royal Society of Chemistry
Release : 2007-10-31
ISBN : 1847557961
Language : En, Es, Fr & De

GET BOOK

Book Description :

Computational methods impact all aspects of modern drug discovery and most notably these methods move rapidly from academic exercises to becoming drugs in clinical trials... This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the factors that determine adsorption, distribution, metabolism, excretion and toxicology are explored, as they remain the critical issues in this area of research. This indispensable resource provides the reader with: * A rich understanding of modern approaches to docking * A comparison and critical evaluation of state-of-the-art methods * Details on harnessing computational methods for both analysis and prediction * An insight into prediction potencies and protocols for unbiased evaluations of docking and scoring algorithms * Critical reviews of current fragment based methods with perceptive applications to kinases Addressing a wide range of uses of protein structures for drug discovery the Editors have created and essential reference for professionals in the pharmaceutical industry and moreover an indispensable core text for all graduate level courses covering molecular interactions and drug discovery.

The Science and Business of Drug Discovery

The Science and Business of Drug Discovery Book
Author : Edward D. Zanders
Publisher : Springer Nature
Release : 2020-11-09
ISBN : 3030578143
Language : En, Es, Fr & De

GET BOOK

Book Description :

The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the twenty chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: Different types of drugs: from small molecules to stem cells Background to chemistry of small and large molecules Historical background to drug discovery, pharmacology and biotechnology The drug discovery pipeline: from target discovery to marketed medicine Commercial aspects of drug discovery Challenges to the biopharmaceutical industry and its responses Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators

Blood Brain Barrier in Drug Discovery

Blood Brain Barrier in Drug Discovery Book
Author : Li Di,Edward H. Kerns
Publisher : John Wiley & Sons
Release : 2014-12-29
ISBN : 1118788540
Language : En, Es, Fr & De

GET BOOK

Book Description :

Focused on central nervous system (CNS) drug discovery efforts,this book educates drug researchers about the blood-brain barrier(BBB) so they can affect important improvements in one of the mostsignificant – and most challenging – areas of drugdiscovery. • Written by world experts to provide practicalsolutions to increase brain penetration or minimize CNSside-effects • Reviews state-of-the-art in silico, in vitro, and invivo tools to assess brain penetration and advanced CNS drugdelivery strategies • Covers BBB physiology, medicinal chemistry designprinciples, free drug hypothesis for the BBB, and transportmechanisms including passive diffusion, uptake/efflux transporters,and receptor-mediated processes • Highlights the advances in modelling BBBpharmacokinetics and dynamics relationships (PK/PD) andphysiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNSdrugs, lessons learned and paths to the market

Applied Biophysics for Drug Discovery

Applied Biophysics for Drug Discovery Book
Author : Donald Huddler,Edward R. Zartler
Publisher : John Wiley & Sons
Release : 2017-07-14
ISBN : 1119099498
Language : En, Es, Fr & De

GET BOOK

Book Description :

Applied Biophysics for Drug Discovery is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns. This text emphasizes practical considerations for selecting and deploying core biophysical method, including but not limited to ITC, SPR, and both ligand-detected and protein-detected NMR. Topics covered include: • Design considerations in biophysical-based lead screening • Thermodynamic characterization of protein-compound interactions • Characterizing targets and screening reagents with HDX-MS • Microscale thermophoresis methods (MST) • Screening with Weak Affinity Chromatography • Methods to assess compound residence time • 1D-NMR methods for hit identification • Protein-based NMR methods for SAR development • Industry case studies integrating multiple biophysical methods This text is ideal for academic investigators and industry scientists planning hit characterization campaigns or designing and optimizing screening strategies.

Anti Inflammatory Drug Discovery

Anti Inflammatory Drug Discovery Book
Author : Jeremy I. Levin,Stefan Laufer
Publisher : Royal Society of Chemistry
Release : 2012
ISBN : 1849734135
Language : En, Es, Fr & De

GET BOOK

Book Description :

A comprehensive review of recent medicinal chemistry approaches to a variety of important therapeutic targets and a key reference for those interested in the prosecution of modern drug discovery programs directed at anti-inflammatory mechanisms of action.

Protein Allostery in Drug Discovery

Protein Allostery in Drug Discovery Book
Author : Jian Zhang,Ruth Nussinov
Publisher : Springer Nature
Release : 2019-11-09
ISBN : 9811387192
Language : En, Es, Fr & De

GET BOOK

Book Description :

The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.

Successful Drug Discovery Volume 5

Successful Drug Discovery  Volume 5 Book
Author : Janos Fischer,Christian Klein,Wayne E. Childers
Publisher : John Wiley & Sons
Release : 2021-02-03
ISBN : 3527826858
Language : En, Es, Fr & De

GET BOOK

Book Description :

Filled with unique insights into current drugs that have made it to the marketplace In the fifth volume of Successful Drug Discovery, the inventors and primary developers of drugs that made it to the market tell the story of the drug's discovery and development. Case studies of drugs from different therapeutic fields reveal the all-too-often unpredictable path from the first drug candidate molecule to the successfully marketed drug. In addition, this new volume addresses overarching topics for drug discovery, such as drug discovery in academia, and discusses currently important classes of small molecule as well as biological drugs. Comprehensive in scope, the book's nine chapters provide a representative cross-section of the present-day drug development effort. The authoritative fifth volume is filled with relevant data and chemical information, as well as the insight and experience of the best contemporary drug creators. This important volume: - Puts the focus on recently introduced drugs that have not yet made it into standard textbooks or general references - Contains information and insight that is new and often not even available from the primary literature - Reveals what it takes to successfully develop a drug molecule that has made it all the way to the market - Is endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC) Written for medicinal chemists, pharmaceutical chemists, organic chemists, Successful Drug Discovery, Volume Five reveals the most recent techniques used by drug innovators in the drug development process.