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Drug Delivery Nanosystems For Biomedical Applications

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Drug Delivery Nanosystems for Biomedical Applications

Drug Delivery Nanosystems for Biomedical Applications Book
Author : Chandra P Sharma
Publisher : Elsevier
Release : 2018-08-22
ISBN : 0323509231
Language : En, Es, Fr & De

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Book Description :

Drug Delivery Nanosystems for Biomedical Application reviews some of the most challenging nanosystems with different routes of delivery that are useful for specific drugs, from both efficacy and bioavailability points-of-view. The chapters explore how this area is developing, the present state of the field, and future developments, in particular, inorganic, metallic, polymeric, composite and lipid nanosystems and their possible evolution to clinical applications. The book is a valuable research reference for both researchers and industrial partners who are not only interested in learning about this area, but also want to gain insights on how to move towards translational research. Focuses on applications, including tissue engineering and regenerative technologies, showing how nanosystems are used in practice Explores how nanosystems are used to deliver a variety of drugs, including peptides, hormone growth factors and genes Assesses the safety and nanotoxicity aspects of drug delivery nanosystems

Nanomaterials and Nanosystems for Biomedical Applications

Nanomaterials and Nanosystems for Biomedical Applications Book
Author : M. Reza Mozafari
Publisher : Springer Science & Business Media
Release : 2007-09-19
ISBN : 1402062893
Language : En, Es, Fr & De

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Book Description :

Under a single cover, this book brings together various aspects of functional bioengineered materials and nanostructured biomaterials including commonly used implants and sustained release nanodevices. The book includes expert reviews on the advances and current problems associated with the implants and nanodevices. Containing recent citations and bibliographies, this book will be an indispensable source of information for new researchers and scientists.

Eine Sammlung von Rissen in Kupfer gestochen zum Vestungs Bau dienlich

Eine Sammlung von Rissen in Kupfer gestochen zum Vestungs Bau dienlich Book
Author : Anonim
Publisher : Unknown
Release : 2022-01-17
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Eine Sammlung von Rissen in Kupfer gestochen zum Vestungs Bau dienlich book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug Delivery Nanosystems

Drug Delivery Nanosystems Book
Author : Natassa Pippa,Costas Demetzos,Stergios Pispas
Publisher : CRC Press
Release : 2019-01-15
ISBN : 0429955227
Language : En, Es, Fr & De

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Book Description :

Nanotechnology seeks to exploit distinct technological advances controlling the structure of nanoscale biomaterials at a nanodimensional scale approaching individual molecules and their aggregates or supramolecular structures. The term "nanomedicine" is used to describe those technologies under the umbrella of nanotechnology that have therapeutic applications in human health. This book presents recent trends and research achievements in the field of pharmaceutical nanotechnology and advanced drug delivery nanosystems, especially for theranostic purposes. The applications of drug delivery nanosystems considered carriers of active pharmaceutical ingredients (APIs) (e.g., proteins, peptides, and nucleic acids) are analyzed on the basis of technology, preparation protocols, and biomedical applications. The book also extensively reports on the principles, design protocols, and applications of nanosystems in drug delivery, imaging, and targeting of active molecules of pharmaceutical interest.

Design Synthesis Multifunctionalization and Biomedical Applications of Multifunctional Mesoporous Silica Based Drug Delivery Nanosystems

Design  Synthesis  Multifunctionalization and Biomedical Applications of Multifunctional Mesoporous Silica Based Drug Delivery Nanosystems Book
Author : Yu Chen
Publisher : Springer
Release : 2015-10-14
ISBN : 3662486229
Language : En, Es, Fr & De

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Book Description :

This thesis reports on essential advances in the design, synthesis and biomedical applications of multifunctional Mesoporous Silica Nanoparticles (MSNs). It provides several examples of multifunctional MSN-based drug delivery nanosystems and demonstrates successful synergistic cancer therapies combining MSNs and high-intensity focused ultrasound. The book will especially be of interest to researchers and graduate students in the fields of biomaterials, biology, chemistry, medicine and the life sciences who are working to develop new methods and technologies to combat cancer.

Biomedical Applications of Nanotechnology

Biomedical Applications of Nanotechnology Book
Author : Vinod Labhasetwar,Diandra L. Leslie-Pelecky
Publisher : John Wiley & Sons
Release : 2007-09-28
ISBN : 9780470152911
Language : En, Es, Fr & De

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Book Description :

An overview of nanotechnology and its potential The field of nanotechnology is undergoing rapid developments on many fronts. This reference provides a comprehensive review of various nanotechnologies with a view to their biomedical applications. With chapters contributed by distinguished scientists from diverse disciplines, Biomedical Applications of Nanotechnology : Reviews recent advances in the designing of various nanotechnologies based on nucleic acids, polymers, biomaterials, and metals Discusses biomedical nanotechnology in areas such as drug and gene delivery Covers advanced aspects of imaging and diagnostics Includes a chapter on the issue of nanotoxicology Complete with figures and tables, this is a practical, hands-on reference book for researchers in pharmaceutical and biotech industries, biomedical engineers, pharmaceutical scientists, pharmacologists, and materials scientists as well as for the policymakers who need to understand the potential of nanotechnology. It is also an excellent resource book for graduate-level students in pharmaceutical sciences, biomedical engineering, and other fields in which nanotechnology is playing an increasingly important role.

Lignin based Materials for Biomedical Applications

Lignin based Materials for Biomedical Applications Book
Author : Patrícia Figueiredo,Hélder A. Santos
Publisher : Elsevier
Release : 2021-07-30
ISBN : 0128203048
Language : En, Es, Fr & De

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Book Description :

Lignin-based Materials for Biomedical Applications: Preparation, Characterization, and Implementation explores the emerging area of lignin-based materials as a platform for advanced biomedical applications, guiding the reader from source through to implementation. The first part of the book introduces the basics of lignin, including extraction methods, chemical modifications, structure and composition, and properties that make lignin suitable for biomedical applications. In addition, structural characterization techniques are described in detail. The next chapters focus on the preparation of lignin-based materials for biomedical applications, presenting methodologies for lignin-based nanoparticles, hydrogels, aerogels, and nanofibers, and providing in-depth coverage of lignin-based materials with specific properties—including antioxidant properties, UV absorbing capability, antimicrobial properties, and colloidal particles with tailored properties—and applications, such as drug and gene delivery, and tissue engineering. Finally, future perspectives and possible new applications are considered. This is an essential reference for all those with an interest in lignin-based materials and their biomedical applications, including researchers and advanced students across bio-based polymers, polymer science, polymer chemistry, biomaterials, nanotechnology, materials science and engineering, drug delivery, and biomedical engineering, as well as industrial R&D and scientists involved with bio-based polymers, specifically for biomedical applications. Unlocks the potential of lignin-based materials with advanced properties for cutting-edge applications in areas such as drug delivery, gene delivery and tissue engineering Presents state-of-the-art methodologies used in the development of lignin-based nanoparticles, hydrogels, aerogels and nanofibers Explains the fundamentals of lignin, including structure and composition, extraction and isolation methods, types and properties, chemical modifications, and characterization techniques

Handbook of Nanobiomedical Research

Handbook of Nanobiomedical Research Book
Author : Vladimir Torchilin
Publisher : World Scientific
Release : 2014
ISBN : 9814520659
Language : En, Es, Fr & De

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Book Description :

This book consists of 4 volumes containing about 70 chapters covering all the major aspects of the growing area of nanomedicine. Leading scientists from 15 countries cover all major areas of nanobiomedical research materials for nanomedicine, application of nanomedicine in therapy of various diseases, use of nanomedicines for diagnostic purposes, technology of nanomedicines, and new trends in nanobiomedical research. This is the first detailed handbook specifically addressing various aspects of nanobiomedicine. Readers are treated to cutting-edge research and the newest data from leading researchers in this area.Contents: "Materials for Nanomedicine: "Liposomal Nanomedicines "(Amr S Abu Lila, Tatsuhiro Ishida and Theresa M Allen)"Solid Lipid Nanoparticles for Biomedical Applications "(Karsten Mader)"Micellar Nanopreparations for Medicine "(Rupa Sawant and Aditi Jhaveri)"Nanoemulsions in Medicine "(William B Tucker and Sandro Mecozzi)"Drug Nanocrystals and Nanosuspensions in Medicine "(Leena Peltonen, Jouni Hirvonen and Timo Laaksonen)"Polymeric Nanosystems for Integrated Image-Guided Cancer Therapy "(Amit Singh, Arun K Iyer and Mansoor M Amiji)"Polysaccharide-Based Nanocarriers for Drug Delivery "(Carmen Teijeiro, Adam McGlone, Noemi Csaba, Marcos Garcia-Fuentes and Maria J Alonso)"Dendrimers for Biomedical Applications "(Lisa M Kaminskas, Victoria M McLeod, Seth A Jones, Ben J Boyd and Christopher J H Porter)"Layer-by-Layer Nanopreparations for Medicine Smart Polyelectrolyte Multilayer Capsules and Coatings "(Rawil F Fakhrullin, Gleb B Sukhorukov and Yuri M Lvov)"Inorganic Nanopreparations for Nanomedicine "(James Ramos and Kaushal Rege)"Silica-Based Nanoparticles for Biomedical Imaging and Drug Delivery Applications "(Stephanie A Kramer and Wenbin Lin)"Carbon Nanotubes in Biomedical Applications "(Krunal K Mehta, Elena E Paskaleva, Jonathan S Dordick and Ravi S Kane)"Core-Shell Nanoparticles for Biomedical Applications "(Mahmoud Elsabahy and Karen L Wooley)"Structure Activity Relationships for Tumor-Targeting Gold Nanoparticles "(Erik C Dreaden, Ivan H El-Sayed and Mostafa A El-Sayed)"Silver Nanoparticles as Novel Antibacterial and Antiviral Agents "(Stefania Galdiero, Annarita Falanga, Marco Cantisani, Avinash Ingle, Massimiliano Galdiero and Mahendra Rai)"Magnetic Nanoparticles for Drug Delivery "(Rainer Tietze, Harald Unterweger and Christoph Alexiou)"Quantum Dots as a Platform Nanomaterial for Biomedical Applications "(Eleonora Petryayeva, Roza Bidshahri, Kate Liu, Charles A Haynes, Igor L Medintz, and W Russ Algar)""Applications in Therapy: "The Application of Nanomedicine to Cardiovascular Diseases "(Kevin M Bardon, Olivier Kister and Jason R McCarthy)"Nanomedicines for Restenosis Therapy "(J E Tengood, I Fishbein, R J Levy and M Chorny)"Nanopreparations for Cancer Treatment and Diagnostics "(Jayant Khandare, Shashwat Banerjee and Tamara Minko)"Nanoparticles in the Gastrointestinal Tract "(Abraham Rubinstein)"Nanopreparations for Oral Administration "(D Hubbard, D J Brayden and H Ghandehari)"Nanopreparations for Central Nervous System Diseases "(Leyuan Xu and Hu Yang)"Nanoparticles for Dermal and Transdermal Delivery: Permeation Pathways and Applications "(Marianna Foldvari, Marjan Gharagozloo and Christine Li)"Lysosomes and Nanotherapeutics: Diseases, Treatments, and Side Effects "(Rachel L Manthe and Silvia Muro)"Nanostructured Biomaterials for Inhibiting Cancer Cell Functions "(Lijuan Zhang and Thomas J Webster)"Nanomedicine in Otorhinolaryngology"

Thermodynamics and Biophysics of Biomedical Nanosystems

Thermodynamics and Biophysics of Biomedical Nanosystems Book
Author : Costas Demetzos,Natassa Pippa
Publisher : Springer
Release : 2019-03-04
ISBN : 9811309892
Language : En, Es, Fr & De

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Book Description :

This book highlights the recent advances of thermodynamics and biophysics in drug delivery nanosystems and in biomedical nanodevices. The up-to-date book provides an in-depth knowledge of bio-inspired nanotechnological systems for pharmaceutical applications. Biophysics and thermodynamics, supported by mathematics, are the locomotive by which the drug transportation and the targeting processes will be achieved under the light of the modern pharmacotherapy. They are considered as scientific tools that promote the understanding of physicochemical and thermotropic functionality and behavior of artificial cell membranes and structures like nanoparticulate systems. Therefore, this book focusses on new aspects of biophysics and thermodynamics as important elements for evaluating biomedical nanosystems, and it correlates their physicochemical, biophysical and thermodynamical behaviour with those of a living organism. In 2018, Prof. Demetzos was honored with an award by the Order of Sciences of the Academy of Athens for his scientific contribution in Pharmaceutical Nanotechnology.

Silica coated Magnetic Nanoparticles

Silica coated Magnetic Nanoparticles Book
Author : Mariela A. Agotegaray,Verónica L. Lassalle
Publisher : Springer
Release : 2017-01-04
ISBN : 3319501585
Language : En, Es, Fr & De

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Book Description :

This brief offers a comprehensive discussion of magnetic targeted drug delivery of silica-coated nanodevices. Focusing on the latest trend in pharmaceutical applications of these nanodevices, a multidisciplinary overview is displayed, from synthesis and design to pharmacokenetics, biodistribution and toxicology. Chapters include design of silica-coated magnetic nanodevices; techniques for drug loading with features applicable to biological systems; synthesis, characterization and the assessment of biomedical issues with both in vitro and in vivo experiments. Applications in the treatment of different localized diseases are also addressed in order to present the potential use of these nanosystems as global, commercially available therapeutics.

Biomedical Composites

Biomedical Composites Book
Author : Amit Kumar Nayak,Md Saquib Hasnain
Publisher : Springer Nature
Release : 2021
ISBN : 9813347538
Language : En, Es, Fr & De

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Book Description :

This book provides an overview of biocomposite chemistry, chemical modifications, characterization and applications in biomedicine, with emphasis on recent advances in the field. Authored by experts, the chapters discuss the design, development and selection of biomedical composites for a particular therapeutic application, as well as providing insight into the regulatory and clinical aspects of biomedical composite use. While this book is primarily intended for scientists from the fields of medical, pharmaceutical, biotechnological and biomedical engineering, it is also useful as an advanced text for students and research scholars.

Drug Delivery Nanosystems

Drug Delivery Nanosystems Book
Author : Natassa Pippa,Costas Demetzos,Stergios Pispas
Publisher : CRC Press
Release : 2019-01-11
ISBN : 0429955219
Language : En, Es, Fr & De

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Book Description :

Nanotechnology seeks to exploit distinct technological advances controlling the structure of nanoscale biomaterials at a nanodimensional scale approaching individual molecules and their aggregates or supramolecular structures. The term "nanomedicine" is used to describe those technologies under the umbrella of nanotechnology that have therapeutic applications in human health. This book presents recent trends and research achievements in the field of pharmaceutical nanotechnology and advanced drug delivery nanosystems, especially for theranostic purposes. The applications of drug delivery nanosystems considered carriers of active pharmaceutical ingredients (APIs) (e.g., proteins, peptides, and nucleic acids) are analyzed on the basis of technology, preparation protocols, and biomedical applications. The book also extensively reports on the principles, design protocols, and applications of nanosystems in drug delivery, imaging, and targeting of active molecules of pharmaceutical interest.

Intracellular Delivery

Intracellular Delivery Book
Author : Aleš Prokop
Publisher : Springer Science & Business Media
Release : 2011-05-26
ISBN : 9400712480
Language : En, Es, Fr & De

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Book Description :

This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly upon existing conservative practices. This volume is a collection of authoritative reviews. In the introductory section we define the field (intracellular delivery). Then, the fundamental routes of nanodelivery devices, cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; at the academic and applied levels, are covered. The following section is dedicated to enhancing delivery via special targeting motifs followed by the introduction of different types of intracellular nanodelivery devices (e.g. a brief description of their chemistry) and ways of producing these different devices. Finally, we put special emphasis on particular disease states and on other biomedical applications, whilst diagnostic and sensing issues are also included. Intracellular delivery / therapy is a highly topical which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is great potential for targeted delivery with improved localized delivery and efficacy.

Nanocarriers for Drug Delivery

Nanocarriers for Drug Delivery Book
Author : Shyam Mohapatra,Shivendu Ranjan,Nandita Dasgupta,Raghvendra Kumar Mishra,Sabu Thomas
Publisher : Elsevier
Release : 2018-10-05
ISBN : 0128140348
Language : En, Es, Fr & De

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Book Description :

Nano-carriers for Drug Delivery: Nanoscience and Nanotechnology in Drug Delivery presents recent discoveries in research on the pharmaceutical applications of the various types of nanosystem-based drug delivery systems. As many nanosystems have reached the market over the past decade, this book proves their benefits to patients. It explores these new carriers and the advances in drug delivery they have facilitated. Reflecting the interdisciplinary nature of the subject matter, the book includes experts from different fields, and with various backgrounds and expertise. It will appeal to researchers and students from different disciplines, such as materials science, technology and various biomedical fields. Coverage includes industrial applications that bridge the gap between lab-based research and practical industrial use. The resulting work is a reference and practical source of guidance for researchers, students and scientists working in the fields of nanotechnology, materials science and technology and biomedical science. Enables readers from different fields to access recent research and protocols across traditional boundaries Focuses on protocols and techniques, as well as the knowledge base of the field, thus enabling those in R&D to learn about, and successfully deploy, cutting-edge techniques Includes sections on nanocarrier systems

Hybrid Nanomaterials

Hybrid Nanomaterials Book
Author : Weibo Cai,Feng Chen
Publisher : CRC Press
Release : 2017-05-25
ISBN : 1315353784
Language : En, Es, Fr & De

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Book Description :

Over the last decade, an unprecedented expansion in the field of nanomedicine has resulted in the development of new nanomaterials for diagnosis and therapy of various diseases such as cancer. This book covers the design, synthesis and applications of various functionally-hybridized nanomaterials for biomedical applications. It includes strategies for design and synthesis of hybrid nanomaterials, surface engineering of various nanoparticle-based hybrid nanosystems for cancer imaging and therapy, toxicity aspects of nanomaterials and the challenges in translation research of hybrid nanomaterials.

Fundamentals of Pharmaceutical Nanoscience

Fundamentals of Pharmaceutical Nanoscience Book
Author : Ijeoma F. Uchegbu,Andreas G. Schätzlein,Woei Ping Cheng,Aikaterini Lalatsa
Publisher : Springer Science & Business Media
Release : 2013-11-23
ISBN : 1461491649
Language : En, Es, Fr & De

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Book Description :

Nanoscience or the science of the very small offers the pharmaceutical scientist a wealth of opportunities. By fabricating at the nanoscale, it is possible to exert unprecedented control on drug activity. This textbook will showcase a variety of nanosystems working from their design and construction to their application in the field of drug delivery. The book is intended for graduate students in drug delivery, physical and polymer chemistry, and applied pharmaceutical sciences courses that involve fundamental nanoscience. The purpose of the text is to present physicochemical and biomedical properties of synthetic polymers with an emphasis on their application in polymer therapeutics i.e., pharmaceutical nanosystems, drug delivery and biological performance. There are two main objectives of this text. The first is to provide advanced graduate students with knowledge of the principles of nanosystems and polymer science including synthesis, structure, and characterization of solution and solid state properties. The second is to describe the fundamentals of therapeutic applications of polymers in drug delivery, targeting, response modifiers as well as regulatory issues. The courses, often listed as Advanced Drug Delivery and Applied Pharmaceutics; Polymer Therapeutics; or Nanomedicine, are designed as an overview of the field specifically for graduate students in the Department of Pharmaceutical Sciences Graduate Programs. However, the course content may also be of interest for graduate students in related biomedical research programs. These courses generally include a discussion of the major principles of polymer science and fundamental concepts of application of polymers as modern therapeutics. All courses are moving away from the above mentioned course names and going by ‘pharmaceutical nanoscience or nanosystems’. This area of research and technology development has attracted tremendous attention during the last two decades and it is expected that it will continue to grow in importance. However, the area is just emerging and courses are limited but they are offered.

Dendrimers in Biomedical Applications

Dendrimers in Biomedical Applications Book
Author : Barbara Klajnert,Ling Peng,Valentin Cena
Publisher : Royal Society of Chemistry
Release : 2013
ISBN : 1849736111
Language : En, Es, Fr & De

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Book Description :

Dendrimers are important molecules that are currently undergoing investigation for use in a variety of different biomedical applications. This book explores the use of dendrimers for a variety of potential functions, including antiamyloidogenic agents, drug delivery systems, nucleic acid and RNA delivery vectors and to produce hybrid fibre platforms for nantechnology. Following the work of COST action TD0802, the main objective of which is to improve existing therapies and find new drugs based on dendrimers, the book will provide comprehensive coverage of dendrimer applications. Coverage includes modelling and molecular dynamic studies of dendrimers and dendrons, anionic dendrimer polymers, cationic carbosilane dendrimers and self-assembled multivalent dendrimers. Providing clear indications for future research and applications, this text will appeal to chemists, biologists and materials scientists, working in both academia and industry.

Drug Delivery Approaches and Nanosystems Two Volume Set

Drug Delivery Approaches and Nanosystems  Two Volume Set Book
Author : Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani
Publisher : CRC Press
Release : 2020-02-10
ISBN : 1351839357
Language : En, Es, Fr & De

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Book Description :

This new two-volume set, Drug Delivery Approaches and Nanosystems, Volume 1: Novel Drug Carriers and Volume 2: Drug Targeting Aspects of Nanotechnology presents a comprehensive look at the state-of-the-art research and developments in drug delivery systems using nanotechnology and its applications. Many methods of drug delivery systems have been used, but very few of them have been validated for medical use. A major reason for the above situation, the editors believe, is due to the gap between academia and research, and the gap between academic research and real-time clinical applications and needs. These volumes address that gap. Volume 1 addresses the ubiquitous applications of nanotechnology or nano-sized materials in the medical field and the real-world challenges and complexities of current drug delivery methodologies and techniques, while Volume 2 focuses on drug targeting aspects of nanotechnology. Together they provide a thorough review of the applications of nanotechnology or nano-sized materials in the medical field and the real-world challenges and complexities of current drug delivery methodologies and techniques. These two volumes will provide a plethora of real-world information for the application of drug delivery approaches via nanotechnology that will be valuable to scientists and researchers as well as faculty and students. The volumes are available separately or together as a set.

Nanomedicine

Nanomedicine Book
Author : Vijay K. Varadan,LinFeng Chen,Jining Xie
Publisher : John Wiley & Sons
Release : 2008-11-20
ISBN : 9780470715628
Language : En, Es, Fr & De

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Book Description :

Recent advances in nanomedicine offer ground-breaking methods for the prevention, diagnosis and treatment of some fatal diseases. Amongst the most promising nanomaterials being developed are magnetic nanomaterials, including magnetic nanoparticles and magnetic nanosensors. Some nanomagnetic medical applications are already commercially available with more set to be released over the coming years. Nanomedicine, Design and Applications of Magnetic Nanomaterials, Nanosensors and Nanosystems presents a comprehensive overview of the biomedical applications of various types of functional magnetic materials. The book provides an introduction to magnetic nanomaterials before systematically discussing the individual materials, their physical and chemical principles, fabrication techniques and biomedical applications. This methodical approach allows this book to be used both as a textbook for beginners to the subject and as a convenient reference for professionals in the field. Discusses magnetic nanoparticles including nanowires, nanotubes, zero-dimensional nanosperes and naturally existing magnetosomes. Examines intrinsically smart magnetic materials and describes their part in the development of biomedical sensors and biochips, which are often used in biomedical tests. Integrates the research efforts of different disciplines – from materials sciences to biology and electrical engineering to medicine – in order to provide a unified and authoritative guide to a richly interdisciplinary field. This volume is of great appeal to students and researchers in the fields of electrical and electronic engineering, biomedical engineering, nanotechnology, materials science, physics, medicine and biology. It is also of interest to practising engineers, materials scientists, chemists and research medical doctors involved in the development of magnetic materials and structures for biomedical applications.

Intracellular Delivery

Intracellular Delivery Book
Author : Ales Prokop
Publisher : Springer
Release : 2011-08-27
ISBN : 9789400712492
Language : En, Es, Fr & De

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Book Description :

This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly upon existing conservative practices. This volume is a collection of authoritative reviews. In the introductory section we define the field (intracellular delivery). Then, the fundamental routes of nanodelivery devices, cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; at the academic and applied levels, are covered. The following section is dedicated to enhancing delivery via special targeting motifs followed by the introduction of different types of intracellular nanodelivery devices (e.g. a brief description of their chemistry) and ways of producing these different devices. Finally, we put special emphasis on particular disease states and on other biomedical applications, whilst diagnostic and sensing issues are also included. Intracellular delivery / therapy is a highly topical which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is great potential for targeted delivery with improved localized delivery and efficacy.