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Drug Biomembrane Interaction Studies

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Drug Biomembrane Interaction Studies

Drug Biomembrane Interaction Studies Book
Author : Rosario Pignatello
Publisher : Elsevier
Release : 2013-10-31
ISBN : 1908818344
Language : En, Es, Fr & De

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Book Description :

The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC is an accurate and rapid thermo-analytical technique, widely used by the pharmaceutical industry and in drug research to investigate several physico-chemical phenomena, such as polymorphism, melting and crystallization, purity, and drug-excipient interaction; as well as characterizing biomolecules such as genetic material. Drug-biomembrane interaction studies is written by scientists renowned for their work in the field of DSC applications to drug development and delivery, and especially to drug-biomembrane interaction studies. The book combines insights from biochemistry and physiology with those from structural biology, nanotechnology and biothermodynamics, to obtain a complete depiction of cell membranes and their functions. Summarizes and updates the recent development in a unique handbook format Consists of a combination of scientific updates within the field Contains chapters written by some of the highest-level experts in the field of DSC

Drug biomembrane interaction studies

Drug   biomembrane interaction studies Book
Author : S. Giatrellis,G. Nounesis
Publisher : Elsevier Inc. Chapters
Release : 2013-10-31
ISBN : 0128091835
Language : En, Es, Fr & De

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Book Description :

DSC is a non-invasive experimental technique, which, besides other numerous applications, has been extensively applied in investigating the thermodynamic properties of synthetic and biological membranes. The calorimetric profiles of phase transitions of self-organized lipid membranes can provide valuable information about membrane interactions with biomolecules, pharmaceutical agents, other membranes, etc. The scope of this chapter is to review specific applications of DSC in studying membrane– nucleic acid interactions, which have attracted scientific attention for their biological relevance, as well as for their potential for biotechnological and pharmaceutical advances.

Drug biomembrane interaction studies

Drug   biomembrane interaction studies Book
Author : C. Carbone,R. Pignatello
Publisher : Elsevier Inc. Chapters
Release : 2013-10-31
ISBN : 0128091819
Language : En, Es, Fr & De

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Book Description :

Interest in using DSC to study the interaction between different compounds and biomembrane models has increased in the last 20years. This is confirmed by the number of published research studies concerning the feasibility of investigating the behavior of different molecules, such as local anesthetics, anticancer drugs, anti-inflammatory drugs, antioxidants, antibiotics, peptides, proteins, polymers, surfactants, genetic materials, macromolecules, and also drug delivery systems (DDSs). This chapter provides a general consideration of the current applications of DSC in evaluating the interaction of different biomolecules and biomembrane models, which will be presented more thoroughly in the succeeding chapters. In particular, a detailed description of the DSC technique for studying the interaction of surfactants, genetic materials, polymers, and DDSs with biomembrane models and biomolecule toxicity studies will be provided, taking into consideration the most recent literature.

Drug biomembrane interaction studies

Drug   biomembrane interaction studies Book
Author : R. Pignatello
Publisher : Elsevier Inc. Chapters
Release : 2013-10-31
ISBN : 0128091789
Language : En, Es, Fr & De

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Book Description :

DSC studies of the interaction between drugs or other biologically active compounds with biomembrane models has often been associated or integrated with other analytical methodologies. The information gained from various techniques can depict the different and complex elements that compose such interactions. This chapter will summarize some recent examples of successfully combining DSC with other physico-chemical methods, such as spectroscopy, chromatography, calorimetry, the Langmuir–Blodgett film technique and microscopy.

Drug biomembrane interaction studies

Drug   biomembrane interaction studies Book
Author : R. Pignatello
Publisher : Elsevier Inc. Chapters
Release : 2013-10-31
ISBN : 0128091762
Language : En, Es, Fr & De

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Book Description :

This chapter will summarize recent information on cell membranes. Their structure, functions and the role of the various components are discussed, considering both their physiological tasks, such as mechanisms of drug internalization into cells, as well as membrane changes associated with or caused by particular disease states. Later chapters will discuss the possibility of testing biomembrane models to study their interaction with drugs and biological compounds.

Drug biomembrane interaction studies

Drug   biomembrane interaction studies Book
Author : A. Fortunato
Publisher : Elsevier Inc. Chapters
Release : 2013-10-31
ISBN : 0128091800
Language : En, Es, Fr & De

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Book Description :

In DSC, the heat flow in and out of a sample and a reference material is measured as a function of temperature as the sample is heated, cooled, or held isothermally at constant temperature. The measurement signal is the energy absorbed or released by the sample in milliwatts. DSC can detect endothermic and exothermic effects, determine peak areas (transition and reaction enthalpies), determine temperatures that characterize a peak or other effects, and measure specific heat capacity. Since the end of the nineteenth century, DSC has been improved and optimized. With the numerous technological innovations, in both hardware and software, it can explore new and demanding applications. Different measurement principles, sensors, signal processing, accessories, and evaluation capabilities make differential scanning calorimetry one of the most common and versatile techniques in material characterization. Today DSC benefits from technological solutions used previously for other applications (MEMS technology, optical devices, and parameter estimation methods).

Drug biomembrane interaction studies

Drug   biomembrane interaction studies Book
Author : A. Wiśniewska-Becker,W.I. Gruszecki
Publisher : Elsevier Inc. Chapters
Release : 2013-10-31
ISBN : 0128091770
Language : En, Es, Fr & De

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Book Description :

Biological membranes consisting of two main components, lipids and proteins, have many important functions in cells. Membrane structure, physical and chemical properties of lipids and proteins, and interactions between them determine membrane functions such as the barrier separating a cell from its environment, selective transport, cell recognition, signalling and compartmentalization of cellular processes. To investigate membrane structure and dynamics, and the interactions between membrane components on a molecular level, simplified artificial models of biological membranes have been developed. Various biophysical techniques are used with these models to study membrane properties and their changes under different environmental factors. This chapter describes common membrane models and some of their applications. There are two groups of models: vesicular models (micelles, bicelles and liposomes) and planar ones (lipid monolayers, supported lipid bilayers, black lipid membranes). The advantages and disadvantages of both types are discussed as well as their usefulness for particular biophysical techniques.

Drug biomembrane interaction studies

Drug   biomembrane interaction studies Book
Author : T. Musumeci,G. Puglisi
Publisher : Elsevier Inc. Chapters
Release : 2013-10-31
ISBN : 0128091851
Language : En, Es, Fr & De

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Book Description :

Antimicrobial agents are from different classes of molecules that suppress multiplication and growth of or kill microorganisms such as bacteria, fungi, or viruses. The precise mechanism of action of some antimicrobial agents is unknown but they must interact with or cross the cell membrane to have an effect. Identification of the damage induced by these compounds is difficult due to the complexity of cell membranes. Studying interactions using membrane models is a first step in obtaining elementary information about the effects of such drugs. We discuss interaction studies in the recent literature that use calorimetric techniques, regarding the mechanism of action or side effects of antimicrobial agents. For interaction studies with mimetic membrane models using DSC analysis, we will try to answer some key questions: (a) Does lipid composition affect the interaction? (b) Does the composition of bilayers influence the secondary structure of a peptide antimicrobial? (c) Does lipid polymorphism influence the activity and toxicity of the molecules? We underline the importance of phospholipids (neutral or anionic) chosen to produce biomembrane vesicles as models for the different studies.

Drug biomembrane interaction studies

Drug   biomembrane interaction studies Book
Author : C. Carbone,T. Musumeci,R. Pignatello
Publisher : Elsevier Inc. Chapters
Release : 2013-10-31
ISBN : 0128091843
Language : En, Es, Fr & De

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Book Description :

Several DSC studies have given a better understanding of the molecular mechanisms of interaction of many non-steroidal anti-inflammatory agents (NSAIDs), such as indomethacin, ibuprofen, naproxen, nimesulide, ketoprofen and oxicam drugs with cell membranes or with simplified phospholipid-based biomembrane models. The consequent changes in the organization, fluidity and permeability of these membranes can, in some instances, be related to the pharmacological profile and toxicology of this drug class. The literature also attests the usefulness of DSC methods in studying the interaction of NSAID-loaded delivery systems (polymeric micro- and nanoparticles, micelles, lipid nanoparticles and prodrugs) with biomembrane models. DSC is also a valid tool for following the release of an anti-inflammatory drug from its carrier.

Drug biomembrane interaction studies

Drug   biomembrane interaction studies Book
Author : M.H. Chiu,N.S. Berezowski,E.J. Prenner
Publisher : Elsevier Inc. Chapters
Release : 2013-10-31
ISBN : 0128091827
Language : En, Es, Fr & De

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Book Description :

DSC is a straightforward, non-perturbing thermodynamic technique first developed in the early 1960s. The large number of parameters and the high sensitivity has made DSC one of the key calorimetric tools used for investigating thermodynamic properties of biopolymers, proteins, peptides and nucleic acids. There are numerous reviews covering the different macromolecular applications of DSC: this chapter will primarily focus on proteins and nucleic acids.

Drug biomembrane interaction studies

Drug   biomembrane interaction studies Book
Author : M. Grazia Sarpietro,F. Castelli
Publisher : Elsevier Inc. Chapters
Release : 2013-10-31
ISBN : 012809186X
Language : En, Es, Fr & De

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Book Description :

This chapter describes a method for evaluating the release of a drug by different delivery systems to biomembrane models made of multilamellar and unilamellar vesicles, using DSC techniques. First, different delivery systems as well as biomembrane models are described followed by a detailed description of the experimental protocols that are the basis of the technique. A drug-loaded delivery system is incubated with the biomembrane model and drug release is evaluated by considering the effect of the drug on the biomembrane’s thermotropic behaviour, and comparing the experimental data with those of the free drug. Finally, examples of the application of this technique are given.

Drug biomembrane interaction studies

Drug   biomembrane interaction studies Book
Author : A. Raudino,M.G. Sarpietro,M. Pannuzzo
Publisher : Elsevier Inc. Chapters
Release : 2013-10-31
ISBN : 0128091797
Language : En, Es, Fr & De

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Book Description :

In this chapter we briefly introduce the main physical principles of DSC as well as related techniques. After a quick survey of the more common experimental techniques, we describe the thermodynamics and kinetics of events accompanying a heating/cooling process. We focus on lipid membranes of one or more components. Both the thermotropic and the barotropic behaviours are investigated, as well as the water/lipid ratio. The effect of foreign impurities (hydrophobic molecules, proteins) dissolved in the lipid matrix on DSC thermotropic behaviour is also investigated, either in the ideal mixing model or for non-ideal miscibility. In the poor miscibility limit, lipids and hydrophobic impurities may undergo phase separation. The mechanisms of phase separation are discussed and related to experimental DSC features. Out-of-equilibrium phenomena, such as the different thermotropic behaviour between heating and cooling modes or the kinetics of lipid/water partitioning, are explained using simple models for phase transitions.

Drug membrane Interactions

Drug membrane Interactions Book
Author : Joachim K. Seydel,Michael Wiese
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Drug membrane Interactions book written by Joachim K. Seydel,Michael Wiese, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug Membrane Interactions

Drug Membrane Interactions Book
Author : Joachim K. Seydel,Michael Wiese
Publisher : John Wiley & Sons
Release : 2009-07-10
ISBN : 3527616497
Language : En, Es, Fr & De

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Book Description :

Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.

Electrochemical Studies on Drug Membrane Interaction

Electrochemical Studies on Drug Membrane Interaction Book
Author : Subramaniam Rameshkumar,Muthunan Thevar Vijayan
Publisher : Unknown
Release : 2018-04-17
ISBN : 9783659977725
Language : En, Es, Fr & De

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Book Description :

Download Electrochemical Studies on Drug Membrane Interaction book written by Subramaniam Rameshkumar,Muthunan Thevar Vijayan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomimetic Lipid Membranes Fundamentals Applications and Commercialization

Biomimetic Lipid Membranes  Fundamentals  Applications  and Commercialization Book
Author : Fatma N. Kök,Ahu Arslan Yildiz,Fatih Inci
Publisher : Springer
Release : 2019-04-16
ISBN : 3030115968
Language : En, Es, Fr & De

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Book Description :

This book compiles the fundamentals, applications and viable product strategies of biomimetic lipid membranes into a single, comprehensive source. It broadens its perspective to interdisciplinary realms incorporating medicine, biology, physics, chemistry, materials science, as well as engineering and pharmacy at large. The book guides readers from membrane structure and models to biophysical chemistry and functionalization of membrane surfaces. It then takes the reader through a myriad of surface-sensitive techniques before delving into cutting-edge applications that could help inspire new research directions. With more than half the world's drugs and various toxins targeting these crucial structures, the book addresses a topic of major importance in the field of medicine, particularly biosensor design, diagnostic tool development, vaccine formulation, micro/nano-array systems, and drug screening/development. Provides fundamental knowledge on biomimetic lipid membranes; Addresses some of biomimetic membrane types, preparation methods, properties and characterization techniques; Explains state-of-art technological developments that incorporate microfluidic systems, array technologies, lab-on-a-chip-tools, biosensing, and bioprinting techniques; Describes the integration of biomimetic membranes with current top-notch tools and platforms; Examines applications in medicine, pharmaceutical industry, and environmental monitoring.

Molecular Biology of the Cell

Molecular Biology of the Cell Book
Author : Bruce Alberts
Publisher : Unknown
Release : 2004
ISBN : 9780815332183
Language : En, Es, Fr & De

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Book Description :

Download Molecular Biology of the Cell book written by Bruce Alberts, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Soft Matter Systems for Biomedical Applications

Soft Matter Systems for Biomedical Applications Book
Author : Leonid Bulavin,Nikolai Lebovka
Publisher : Springer Nature
Release : 2021-09-27
ISBN : 3030809242
Language : En, Es, Fr & De

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Book Description :

This book addresses new challenges in soft matter and colloids. It presents timely reports on colloidal self-assembly, soft matters from liquid crystals, nanoparticles in liquid crystals, hydrocolloids, hybrid nanosystems, nanosuspensions, and dispersion of nanoparticles in different media, soft matter processing and modern experiments related with soft matters.

Advances in Biomembranes and Lipid Self Assembly

Advances in Biomembranes and Lipid Self Assembly Book
Author : Ales Iglic,Michael Rappolt,Patricia Losada Perez
Publisher : Academic Press
Release : 2022-06-15
ISBN : 0323988466
Language : En, Es, Fr & De

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Book Description :

Advances in Biomembranes and Lipid Self-Assembly, Volume 35, formerly titled Advances in Planar Lipid Bilayers and Liposomes, provides a global platform for the study of cell membranes, lipid model membranes and lipid self-assemblies, from the micro- to the nanoscale. As planar lipid bilayers are widely studied due to their ubiquity in nature, this book presents research on their application in the formulation of biomimetic model membranes, and in the design of artificial dispersion of liposomes. Chapters cover Physical properties of SOPC lipid membranes containing cholesterol by molecular dynamics simulation, Exciting membrane fluctuations - more than thermal stimulation, Fluctuations shaping bio-membrane adhesion, and more. Surveys recent theoretical and experimental results on lipid micro- and nanostructures Presents potential use applications, such as clinically relevant diagnostic and therapeutic procedures, biotechnology, pharmaceutical engineering and food products Includes both original research and comprehensive reviews written by world-leading experts and young researchers Provides a global platform for a broad community of experimental and theoretical researchers studying cell membranes, lipid model membranes, and lipid self-assemblies, from the micro- to the nanoscale

An Introduction to Biological Membranes

An Introduction to Biological Membranes Book
Author : William Stillwell
Publisher : Newnes
Release : 2013-04-20
ISBN : 0080931286
Language : En, Es, Fr & De

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Book Description :

An Introduction to Biological Membranes: From Bilayers to Rafts covers many aspects of membrane structure/function that bridges membrane biophysics and cell biology. Offering cohesive, foundational information, this publication is valuable for advanced undergraduate students, graduate students and membranologists who seek a broad overview of membrane science. Brings together different facets of membrane research in a universally understandable manner Emphasis on the historical development of the field Topics include membrane sugars, membrane models, membrane isolation methods, and membrane transport.