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Drug Biomembrane Interaction Studies

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Drug Biomembrane Interaction Studies

Drug Biomembrane Interaction Studies Book
Author : Rosario Pignatello
Publisher : Elsevier
Release : 2013-10-31
ISBN : 1908818344
Language : En, Es, Fr & De

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Book Description :

The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC is an accurate and rapid thermo-analytical technique, widely used by the pharmaceutical industry and in drug research to investigate several physico-chemical phenomena, such as polymorphism, melting and crystallization, purity, and drug-excipient interaction; as well as characterizing biomolecules such as genetic material. Drug-biomembrane interaction studies is written by scientists renowned for their work in the field of DSC applications to drug development and delivery, and especially to drug-biomembrane interaction studies. The book combines insights from biochemistry and physiology with those from structural biology, nanotechnology and biothermodynamics, to obtain a complete depiction of cell membranes and their functions. Summarizes and updates the recent development in a unique handbook format Consists of a combination of scientific updates within the field Contains chapters written by some of the highest-level experts in the field of DSC

Drug biomembrane interaction studies

Drug   biomembrane interaction studies Book
Author : A. Fortunato
Publisher : Elsevier Inc. Chapters
Release : 2013-10-31
ISBN : 0128091800
Language : En, Es, Fr & De

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Book Description :

In DSC, the heat flow in and out of a sample and a reference material is measured as a function of temperature as the sample is heated, cooled, or held isothermally at constant temperature. The measurement signal is the energy absorbed or released by the sample in milliwatts. DSC can detect endothermic and exothermic effects, determine peak areas (transition and reaction enthalpies), determine temperatures that characterize a peak or other effects, and measure specific heat capacity. Since the end of the nineteenth century, DSC has been improved and optimized. With the numerous technological innovations, in both hardware and software, it can explore new and demanding applications. Different measurement principles, sensors, signal processing, accessories, and evaluation capabilities make differential scanning calorimetry one of the most common and versatile techniques in material characterization. Today DSC benefits from technological solutions used previously for other applications (MEMS technology, optical devices, and parameter estimation methods).

Drug biomembrane interaction studies

Drug   biomembrane interaction studies Book
Author : M.H. Chiu,N.S. Berezowski,E.J. Prenner
Publisher : Elsevier Inc. Chapters
Release : 2013-10-31
ISBN : 0128091827
Language : En, Es, Fr & De

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Book Description :

DSC is a straightforward, non-perturbing thermodynamic technique first developed in the early 1960s. The large number of parameters and the high sensitivity has made DSC one of the key calorimetric tools used for investigating thermodynamic properties of biopolymers, proteins, peptides and nucleic acids. There are numerous reviews covering the different macromolecular applications of DSC: this chapter will primarily focus on proteins and nucleic acids.

Drug biomembrane interaction studies

Drug   biomembrane interaction studies Book
Author : C. Carbone,R. Pignatello
Publisher : Elsevier Inc. Chapters
Release : 2013-10-31
ISBN : 0128091819
Language : En, Es, Fr & De

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Book Description :

Interest in using DSC to study the interaction between different compounds and biomembrane models has increased in the last 20years. This is confirmed by the number of published research studies concerning the feasibility of investigating the behavior of different molecules, such as local anesthetics, anticancer drugs, anti-inflammatory drugs, antioxidants, antibiotics, peptides, proteins, polymers, surfactants, genetic materials, macromolecules, and also drug delivery systems (DDSs). This chapter provides a general consideration of the current applications of DSC in evaluating the interaction of different biomolecules and biomembrane models, which will be presented more thoroughly in the succeeding chapters. In particular, a detailed description of the DSC technique for studying the interaction of surfactants, genetic materials, polymers, and DDSs with biomembrane models and biomolecule toxicity studies will be provided, taking into consideration the most recent literature.

Drug biomembrane interaction studies

Drug   biomembrane interaction studies Book
Author : R. Pignatello
Publisher : Elsevier Inc. Chapters
Release : 2013-10-31
ISBN : 0128091789
Language : En, Es, Fr & De

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Book Description :

DSC studies of the interaction between drugs or other biologically active compounds with biomembrane models has often been associated or integrated with other analytical methodologies. The information gained from various techniques can depict the different and complex elements that compose such interactions. This chapter will summarize some recent examples of successfully combining DSC with other physico-chemical methods, such as spectroscopy, chromatography, calorimetry, the Langmuir–Blodgett film technique and microscopy.

Drug biomembrane interaction studies

Drug   biomembrane interaction studies Book
Author : T. Musumeci,G. Puglisi
Publisher : Elsevier Inc. Chapters
Release : 2013-10-31
ISBN : 0128091851
Language : En, Es, Fr & De

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Book Description :

Antimicrobial agents are from different classes of molecules that suppress multiplication and growth of or kill microorganisms such as bacteria, fungi, or viruses. The precise mechanism of action of some antimicrobial agents is unknown but they must interact with or cross the cell membrane to have an effect. Identification of the damage induced by these compounds is difficult due to the complexity of cell membranes. Studying interactions using membrane models is a first step in obtaining elementary information about the effects of such drugs. We discuss interaction studies in the recent literature that use calorimetric techniques, regarding the mechanism of action or side effects of antimicrobial agents. For interaction studies with mimetic membrane models using DSC analysis, we will try to answer some key questions: (a) Does lipid composition affect the interaction? (b) Does the composition of bilayers influence the secondary structure of a peptide antimicrobial? (c) Does lipid polymorphism influence the activity and toxicity of the molecules? We underline the importance of phospholipids (neutral or anionic) chosen to produce biomembrane vesicles as models for the different studies.

Indian Science Abstracts

Indian Science Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Indian Science Abstracts book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Methods in Membrane Lipids

Methods in Membrane Lipids Book
Author : Alex Dopico
Publisher : Springer Science & Business Media
Release : 2007-08-30
ISBN : 1588296628
Language : En, Es, Fr & De

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Book Description :

This book presents a compendium of methodologies for the study of membrane lipids, varying from traditional lab bench experimentation to computer simulation and theoretical models. The volume provides a comprehensive set of techniques for studying membrane lipids with a strong biophysical emphasis. It compares the various available techniques including the pros and cons as seen by the experts.

Thermal Analysis in Research and Industry

Thermal Analysis in Research and Industry Book
Author : Indra K. Varma,A. C. Momin
Publisher : Unknown
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Thermal Analysis in Research and Industry book written by Indra K. Varma,A. C. Momin, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Progress and Trends in Applied Optical Spectroscopy

Progress and Trends in Applied Optical Spectroscopy Book
Author : Dieter Fassler
Publisher : B. G. Teubner Gmbh
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Progress and Trends in Applied Optical Spectroscopy book written by Dieter Fassler, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

QSAR and Molecular Modeling Studies in Heterocyclic Drugs I

QSAR and Molecular Modeling Studies in Heterocyclic Drugs I Book
Author : S.P. Gupta
Publisher : Springer Verlag
Release : 2006-06-22
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download QSAR and Molecular Modeling Studies in Heterocyclic Drugs I book written by S.P. Gupta, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

CA Reviews Index CARI

CA Reviews Index  CARI   Book
Author : Anonim
Publisher : Unknown
Release : 1982
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download CA Reviews Index CARI book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Membrane Mechanisms of Drugs of Abuse

Membrane Mechanisms of Drugs of Abuse Book
Author : Charles William Sharp,Leo G. Abood
Publisher : Unknown
Release : 1979
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Membrane Mechanisms of Drugs of Abuse book written by Charles William Sharp,Leo G. Abood, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Annual Guides to Graduate Study

The Annual Guides to Graduate Study Book
Author : Anonim
Publisher : Unknown
Release : 1974
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Annual Guides to Graduate Study book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Survey of Drug Research in Immunologic Disease

Survey of Drug Research in Immunologic Disease Book
Author : Vassil St Georgiev
Publisher : Unknown
Release : 1983
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Survey of Drug Research in Immunologic Disease book written by Vassil St Georgiev, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Unlisted Drugs

Unlisted Drugs Book
Author : Anonim
Publisher : Unknown
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Unlisted Drugs book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Infrared Spectroscopy of Biomolecules

Infrared Spectroscopy of Biomolecules Book
Author : Henry H. Mantsch,Dennis Chapman
Publisher : Wiley-Liss
Release : 1996-03
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Infrared Spectroscopy of Biomolecules Edited by Henry H. Mantsch and Dennis Chapman Dramatic new advances in the application of infrared spectroscopy to biomolecules and instrumentation are revolutionizing this branch of molecular spectroscopy. Infrared Spectroscopy of Biomolecules provides an up-to-date, detailed look at the different spectroscopic techniques now available and offers a framework for progression in the field, including the evolution of Fourier transform methods, the development of time-resolved techniques and difference spectroscopy, as well as new modulation methods. The book begins with a fundamental introduction to the theories behind both infrared spectroscopy and the Fourier transform method, which lays the groundwork for the instrumental and mathematical chapters that follow. Once the basics of the infrared methods are established, the proceeding chapters cover the application of infrared spectroscopy to proteins, lipids, enzymes, nucleic acids, carbohydrates, and biomembranes. Other chapters in this excellent reference include: Theoretical Analyses of the Amide I Infrared Bands of Globular Proteins Slow and Fast Infrared Kinetic Studies Fourier Transform Infrared Spectroscopy of Cell Surface Polysaccharides What Can Infrared Spectroscopy Tell Us About the Structure and Composition of Intact Bacterial Cells Biomedical Infrared Spectroscopy Editors Henry Mantsch and Dennis Chapman, leading experts in the field, conclude with an exciting look at much-anticipated future developments, including the use of caged compounds and studies of oxidation reduction systems within the IR spectrometer. A solid introduction to the basics with up-to-the-minute coverage of the latest developments in the field, Infrared Spectroscopy of Biomolecules is an indispensable reference tool for biochemists, biophysicists, and structural biologists alike.

Advances in Drug Delivery Systems 3

Advances in Drug Delivery Systems  3 Book
Author : James M. Anderson,Sung Wan Kim
Publisher : Elsevier Science Limited
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Advances in Drug Delivery Systems 3 book written by James M. Anderson,Sung Wan Kim, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Zeitschrift F r Naturforschung

Zeitschrift F  r Naturforschung Book
Author : Anonim
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Indian Journal of Pure Applied Physics

Indian Journal of Pure   Applied Physics Book
Author : Anonim
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Indian Journal of Pure Applied Physics book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.