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Domino Reactions in Organic Synthesis

Domino Reactions in Organic Synthesis Book
Author : Lutz F. Tietze,Gordon Brasche,Kersten Gericke
Publisher : John Wiley & Sons
Release : 2006-12-13
ISBN : 3527608680
Language : En, Es, Fr & De

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Book Description :

Domino reactions enable you to build complex structures in one-pot reactions without the need to isolate intermediates- a dream comes true. In this book, the well-respected expert, Professor Lutz Tietze, summarizes the possibilities of this reaction type - an approach for an efficiant, economically benificial and ecological benign synthesis. A definite must for every organic chemist.

Domino Reactions

Domino Reactions Book
Author : Lutz F. Tietze
Publisher : John Wiley & Sons
Release : 2013-12-23
ISBN : 3527671323
Language : En, Es, Fr & De

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Book Description :

The follow-up to the successful "Domino Reaction in Organic Synthesis", this ready reference brings up to date on the original concept. The chapters have been arranged according to the name of well-known transformations of the first step and in combination with the formed products. Each chapter is written by an internationally renowned expert, and the book is edited by L. F. Tietze, who established the concept of domino reactions. The one-stop source for all synthetic chemists to improve the synthetic efficiency and allow an ecologically and economically beneficial preparation of every chemical compound.

Domino Reactions in Organic Synthesis

Domino Reactions in Organic Synthesis Book
Author : Lutz F. Tietze,Gordon Brasche,Kersten Gericke
Publisher : Wiley-VCH
Release : 2006-09-11
ISBN : 9783527290604
Language : En, Es, Fr & De

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Book Description :

Domino reactions enable you to build complex structures in one-pot reactions without the need to isolate intermediates- a dream comes true. In this book, the well-respected expert, Professor Lutz Tietze, summarizes the possibilities of this reaction type - an approach for an efficiant, economically benificial and ecological benign synthesis. A definite must for every organic chemist.

Special Topic Domino Reactions Tandem Transformations in Organic Synthesis

Special Topic Domino Reactions  Tandem Transformations in Organic Synthesis Book
Author : Erick M. Carreira
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Special Topic Domino Reactions Tandem Transformations in Organic Synthesis book written by Erick M. Carreira, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Applications of Domino Transformations in Organic Synthesis Volume 1

Applications of Domino Transformations in Organic Synthesis  Volume 1 Book
Author : Scott A. Snyder
Publisher : Georg Thieme Verlag
Release : 2016-05-11
ISBN : 3132028517
Language : En, Es, Fr & De

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Book Description :

The rapid pace of evolution in domino, or cascade-based transformations has revolutionized the practice of chemical synthesis for the creation of natural products, designed molecules, and pharmaceuticals. "Science of Synthesis: Applications of Domino Transformations in Organic Synthesis" explores the topic thoroughly and systematically, serving as the basis for practical applications and future research. The 2-volume set presents the cutting-edge in terms of design, strategy, and experimental procedures, leading to multiple events being accomplished within a single reaction vessel. The content is organized by the core type of reaction used to initiate the event, be it a pericyclic reaction, a metal-mediated transformation, radical chemistry, or an acid-induced cascade among many others. Volume 1 covers polyene/cation-pi cyclizations, metathesis, radical, and metal-mediated reactions, and non-radical skeletal rearrangements.

Reactions and Syntheses

Reactions and Syntheses Book
Author : Lutz F. Tietze,Theophil Eicher,Ulf Diederichsen,Andreas Speicher,Nina Schützenmeister
Publisher : John Wiley & Sons
Release : 2015-06-22
ISBN : 3527338144
Language : En, Es, Fr & De

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Book Description :

"The second edition of this classic text book has been completely revised, updated, and extended to include chapters on biomimetic amination reactions, Wacker oxidation, and useful domino reactions. The first-class author team with long-standing experience in practical courses on organic chemistry covers a multitude of preparative procedures of reaction types and compound classes indispensable in modern organic synthesis. Throughout, the experiments are accompanied by the theoretical and mechanistic fundamentals, while the clearly structured sub-chapters provide concise background information, retrosynthetic analysis, information on isolation and purification, analytical data as well as current literature citations. Finally, in each case the synthesis is labeled with one of three levels of difficulty. An indispensable manual for students and lecturers in chemistry, organic chemists, as well as lab technicians and chemists in the pharmaceutical and agrochemical industries."--P. [4] of cover.

Advances in Induction and Microwave Heating of Mineral and Organic Materials

Advances in Induction and Microwave Heating of Mineral and Organic Materials Book
Author : Stanisław Grundas
Publisher : IntechOpen
Release : 2011-02-14
ISBN : 9789533075228
Language : En, Es, Fr & De

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Book Description :

The book offers comprehensive coverage of the broad range of scientific knowledge in the fields of advances in induction and microwave heating of mineral and organic materials. Beginning with industry application in many areas of practical application to mineral materials and ending with raw materials of agriculture origin the authors, specialists in different scientific area, present their results in the two sections: Section 1-Induction and Microwave Heating of Mineral Materials, and Section 2-Microwave Heating of Organic Materials.

Asymmetric Domino Reactions

Asymmetric Domino Reactions Book
Author : Hélène Pellissier
Publisher : Royal Society of Chemistry
Release : 2013-03-13
ISBN : 1849736510
Language : En, Es, Fr & De

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Book Description :

This book covers the latest developments in asymmetric domino reactions, focussing on those published in the last 6 years. These fascinating reactions have rapidly become one of the most current fields in organic chemistry, since they allow reaching easily high molecular complexity in an economically favourable way with advantages of savings in solvent, time, energy, and costs. Unsurprisingly, the high levels of efficiency and enantioselectivity generally reached in these reactions have been exploited for the production of a wide number of complex chiral molecules with dense stereochemistry and functionality, which are motifs present in biologically active compounds and natural products. The book is divided into three principal sections, dealing successively with asymmetric domino reactions based on the use of chiral auxiliaries, asymmetric domino reactions based on the use of chiral metal catalysts, and asymmetric domino reactions based on the use of chiral organocatalysts, covering the literature since the beginning of 2006try{F5_flush(document);}catch(e){}

Asymmetric Metal Catalysis in Enantioselective Domino Reactions

Asymmetric Metal Catalysis in Enantioselective Domino Reactions Book
Author : Helene Pellissier
Publisher : John Wiley & Sons
Release : 2019-10-07
ISBN : 3527346198
Language : En, Es, Fr & De

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Book Description :

Introduces an innovative and outstanding tool for the easy synthesis of complex chiral structures in a single step Covering all of the literature since the beginning of 2006, this must-have book for chemists collects the major progress in the field of enantioselective one-, two-, and multicomponent domino reactions promoted by chiral metal catalysts. It clearly illustrates how enantioselective metal-catalyzed processes constitute outstanding tools for the development of a wide variety of fascinating one-pot asymmetric domino reactions, thereby allowing many complex products to be easily generated from simple materials in one step. The book also strictly follows the definition of domino reactions by Tietze as single-, two-, as well as multicomponent transformations. Asymmetric Metal Catalysis in Enantioselective Domino Reactions is divided into twelve chapters, dealing with enantioselective copper-, palladium-, rhodium-, scandium-, silver-, nickel-, gold-, magnesium-, cobalt-, zinc-, yttrium and ytterbium-, and other metal-catalyzed domino reactions. Most of the chapters are divided into two parts dealing successively with one- and two-component domino reactions, and three-component processes. Each part is subdivided according to the nature of domino reactions. Each chapter of the book includes selected applications of synthetic methodologies to prepare natural and biologically active products. -Presents the novel combination of asymmetric metal catalysis with the concept of fascinating domino reactions, which allows high molecular complexity with a remarkable level of enantioselectivity -Showcases an incredible tool synthesizing complex and diverse chiral structures in a single reaction step -Includes applications in total synthesis of natural products and biologically active compounds -Written by a renowned international specialist in the field -Stimulates the design of novel asymmetric domino reactions and their use in the synthesis of natural products, pharmaceuticals, agrochemicals, and materials Asymmetric Metal Catalysis in Enantioselective Domino Reactions will be of high interest to synthetic, organic, medicinal, and catalytic chemists in academia and R&D departments.

Synthetic Endeavours in Nitrogen Heterocycles

Synthetic Endeavours in Nitrogen Heterocycles Book
Author : Charles Hamilton Heath
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This thesis describes our synthetic endeavours in nitrogen containing heterocyclic compounds. The work included several key themes including the pursuit of biologically active compounds, the development of elegant and environmentally benign procedures including domino reactions. The use of palladium mediated transformations in organic synthesis, the construction of new unknown ring systems and the structural elucidation of heterocyclic compounds including the structural elucidation of natural products by synthesis have also been explored. Chapter 2 describes our synthetic investigations of the 3-benzazepines I and azepino[4,5-b]indoles II. Through the use of the palladium catalysed Tsuji-Trost reaction followed by a Heck reaction we were able to devise a synthetic approach to access these N-heterocycles. We were able to synthesize simple derivatives of both I and II in addition to more complex compounds featuring additional fused rings by including the use of different cyclic and acyclic allylic substrates for the Tsuji-Trost reaction. After the development of the single step Tsuji-Trost/Heck synthetic protocols for these compounds we successfully combined these two reactions into a single pot domino reaction. In addition to Tsuji-Trost/Heck domino reactions we have also developed a Heck/carbopalladation domino reaction for the synthesis of an azepino[3,4,5-hi]benz[b]indolizine derivative. Chapter 3 describes our attempts to synthesize the natural product arboflorine. We initially began with attempts to elaborate the azepino[4,5-b]indoles synthesized in Chapter 2 to provide arboflorine, however this did not prove fruitful. In the course of this investigation we discovered a novel rearrangement of an azepino[4,5-b]indole to give the peroxide IV which became the topic of Chapter 4. We attempted to further elaborate other known azepino[4,5-b]indoles via a variety of methods including inter and intramolecular Heck reactions, radical chain reactions and functionalization via an iminium salt. These attempts were also unsuccessful. Finally we chose to modify the synthesis of a simpler, related tetracycle for the synthesis of arboflorine, developed by Bosch and Passarella. Following their general synthetic strategy we were able to synthesize a key nitrile intermediate to the synthesis of arboflorine. The cyclization of this nitrile was attempted but was not successful under a series of reaction conditions. Chapter 4 describes the structural elucidation of the peroxide IV. A possible mechanistic explanation for the formation of the peroxide is given and this is discussed in the context of relevant literature examples. The formation of the peroxide IV led to our increased interest in the general reactivity of the azepino[4,5-b]indoles and several simple reactions were carried out in the hope of discovering further novel rearrangements.

Applications of Domino Transformations in Organic Synthesis

Applications of Domino Transformations in Organic Synthesis Book
Author : Scott A. Snyder
Publisher : Georg Thieme Verlag
Release : 2016-05-11
ISBN : 3132211710
Language : En, Es, Fr & De

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Book Description :

The rapid pace of evolution in domino, or cascade-based transformations has revolutionized the practice of chemical synthesis for the creation of natural products, designed molecules, and pharmaceuticals. "Science of Synthesis: Applications of Domino Transformations in Organic Synthesis" explores the topic thoroughly and systematically, serving as the basis for practical applications and future research. The 2-volume set presents the cutting-edge in terms of design, strategy, and experimental procedures, leading to multiple events being accomplished within a single reaction vessel. The content is organized by the core type of reaction used to initiate the event, be it a pericyclic reaction, a metal-mediated transformation, radical chemistry, or an acid-induced cascade among many others. Volume 2 covers pericyclic reactions (Diels-Alder, sigmatropic shifts, ene reactions), dearomatizations, and additions to C-O/C-N multiple bonds.

Hydroformylation for Organic Synthesis

Hydroformylation for Organic Synthesis Book
Author : Maurizio Taddei,André Mann
Publisher : Springer
Release : 2014-07-08
ISBN : 3642450598
Language : En, Es, Fr & De

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Book Description :

The Role of Metals and Ligands in Organic Hydroformylation, by Luca Gonsalvi, Antonella Guerriero, Eric Monflier, Frédéric Hapiot, Maurizio Peruzzini. Hydroformylation in Aqueous Biphasic Media Assisted by Molecular Receptors, by Frédéric Hapiot, Hervé Bricout, Sébastien Tilloy, Eric Monflier. Asymmetric Hydroformylation, by Bernabé F. Perandones, Cyril Godard, Carmen Claver. Domino Reactions Triggered by Hydroformylation, by Elena Petricci, Elena Cini. Rhodium-Catalyzed Hydroformylation in Fused Azapolycycles Synthesis, by Roberta Settambolo. Hydroformylation in Natural Product Synthesis, by Roderick W. Bates, Sivarajan Kasinathan.

Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience

Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience Book
Author : Zbigniew J. Witczak,Roman Bielski
Publisher : John Wiley & Sons
Release : 2016-01-14
ISBN : 1119044391
Language : En, Es, Fr & De

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Book Description :

The book consists of a brief introduction, a foreward provided byprofessor Danishefsky of Columbia University, and about 14 –16 chapters, each written by one or two eminent scholars/authorsdescribing their recent research in the area of either dominoreactions or intramolecular rearrangements in carbohydratechemistry. Three or four chapters will be reviews. The domino (cascade, tandem)reactions are always intramolecular. They are usually very fast,clean and offer highly complex structures in a one pot process.Intramolecular rearrangements offer very similar advantages andoften lead to highly complex products as well. Although manyrecently isolated carbohydrates fulfill various sophisticatedfunctions, their structures are often very complex. The editorscover the broadest scope of novel methodologies possible. All thesynthetic and application aspects of domino/cascade reactions areexplored in this book. A second theme that will be covered isintramolecular rearrangement, which is also fast, stereoselective,and often constitutes one or more steps of domino /cascade process.Selected examples of intramolecular rearrangements are presented.Together, both processes offer an elegant and convenient approach to the synthesis of many complex molecules,which are normally difficult to synthesize via alternative routes.It appears that domino and intramolecular rearrangements areideally suited to synthesize certain specific modifiedmonosaccharides. What is particularly important is that bothprocesses are intermolecular and almost always yield products withvery well-defined stereochemistry. This high definition isabsolutely crucial when synthesizing advanced, modified mono andoligosaccharides. The choice of contributors reflects anemphasis on both therapeutic and pharmacological aspects of carbohydratechemistry.

Classics in Total Synthesis II

Classics in Total Synthesis II Book
Author : K. C. Nicolaou,S. A. Snyder
Publisher : Wiley-VCH
Release : 2003-10-17
ISBN : 9783527306848
Language : En, Es, Fr & De

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Book Description :

Classics in Total Synthesis II is the long awaited sequel to Classics in Total Synthesis, a book that has made its mark as a superb tool for educating students and practitioners alike in the art of organic synthesis since its introduction in 1996. In this highly welcomed new volume, K. C. Nicolaou and Scott A. Snyder discuss in detail the most impressive accomplishments in natural product total synthesis during the 1990s and the first years of the 21st century. While all of the features that made the first volume of Classics so popular and unique as a teaching tool have been maintained, in this new treatise the authors seek to present the latest techniques and advances in organic synthesis as they beautifully describe the works of some of the most renowned synthetic organic chemists of our time. · domino reactions, cascade sequences, biomimetic strategies, and asymmetric catalysis are systematically developed through the chosen synthesis · cutting edge synthetic technologies are discussed in terms of mechanism and scope · new reactions, such as olefin metathesis, are presented in mini-review style · abundant references are given for further reading Graduate students, educators, and researchers in the fields of synthetic and medicinal chemistry will wish to have a copy of this book in their collection as an indispensable companion that both augments and supplements the original Classics in Total Synthesis. From reviews of "Classics in Total Synthesis": "... a volume, (..) which any chemist with an interest in synthetic organic chemistry will wish to acquire." JACS "...this superb book (..) will be an essential purchase for many organic chemists." Nature

Organic Reactions Volume 101

Organic Reactions  Volume 101 Book
Author : Anonim
Publisher : John Wiley & Sons
Release : 2020-03-17
ISBN : 1119644771
Language : En, Es, Fr & De

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Book Description :

The 101st volume in this series for organic chemists in academia and industry presents critical discussions of widely used organic reactions or particular phases of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method.

Stereoselective Multiple Bond Forming Transformations in Organic Synthesis

Stereoselective Multiple Bond Forming Transformations in Organic Synthesis Book
Author : Jean Rodriguez,Damien Bonne
Publisher : John Wiley & Sons
Release : 2015-04-08
ISBN : 1119006422
Language : En, Es, Fr & De

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Book Description :

Combining the important research topic of multiple bond-forming transformations with green chemistry, this book helps chemists identify recent sustainable stereoselective synthetic sequences. • Combines the important research topic of multiple bond-forming transformations with green chemistry and sustainable development • Offers a valuable resource for preparing compounds with multiple stereogenic centers, an important field for synthetic chemists • Organizes chapters by molecular structure of final products, making for a handbook-style resource • Discusses applications of the synthesis of natural products and of drug intermediates • Brings together otherwise-scattered information about a number of key, efficient chemical reactions

Reactive Intermediates in Organic Chemistry

Reactive Intermediates in Organic Chemistry Book
Author : Maya Shankar Singh
Publisher : John Wiley & Sons
Release : 2014-01-22
ISBN : 3527678271
Language : En, Es, Fr & De

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Book Description :

Most reactions in organic chemistry do not proceed in a single step but rather take several steps to yield the desired product. In the course of these multi-step reaction sequences, short-lived intermediates can be generated that quickly convert into other intermediates, reactants, products or side products. As these intermediates are highly reactive, they cannot usually be isolated, but their existence and structure can be proved by theoretical and experimental methods. Using the information obtained, researchers can better understand the underlying reaction mechanism of a certain organic transformation and thus develop novel strategies for efficient organic synthesis. The chapters are clearly structured and are arranged according to the type of intermediate, providing information on the formation, characterization, stereochemistry, stability, and reactivity of the intermediates. Additionally, representative examples and a problem section with different levels of difficulty are included for self-testing the newly acquired knowledge. By providing a deeper understanding of the underlying concepts, this is a musthave reference for PhD and Master Students in organic chemistry, as well as a valuable source of information for chemists in academia and industry working in the field. It is also ideal as primary or supplementary reading for courses on organic chemistry, physical organic chemistry or analytical chemistry.

Science of Synthesis

Science of Synthesis Book
Author : S. A. Snyder
Publisher : Unknown
Release : 2015-11
ISBN : 9783132211414
Language : En, Es, Fr & De

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Book Description :

This reference work on domino chemistry covers the myriad ways that these sequences can be achieved with the full array of reactivity available, whether in the form of pericyclic reactions, radical transformations, anionic and cationic chemistry, metal-based cross couplings, and combinations thereof. The sections within this book have been organized principally by the type of reaction that initiates the sequence. Importantly, only key and representative examples have been provided to highlight the best practices and procedures that have broad applicability. The hope is that this structure will afford a clear sense of current capabilities as well as highlight areas for future development and research.

Hydroformylation for Organic Synthesis

Hydroformylation for Organic Synthesis Book
Author : Maurizio Taddei,André Mann
Publisher : Unknown
Release : 2014-02-28
ISBN : 9783642450600
Language : En, Es, Fr & De

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Book Description :

Download Hydroformylation for Organic Synthesis book written by Maurizio Taddei,André Mann, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Modern Tools for the Synthesis of Complex Bioactive Molecules

Modern Tools for the Synthesis of Complex Bioactive Molecules Book
Author : Stellios Arseniyadis
Publisher : John Wiley & Sons
Release : 2012-10-09
ISBN : 9780470616185
Language : En, Es, Fr & De

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Book Description :

"This book provides an overview of the new technologies that have revolutionized organic chemistry and allowed an easy access to very important complex bioactives. It is the only book of its kind assocating modern synthetic techniques and structurally complex bioactives, and includes some representative experimental procedures for particular methods. The synthesis of structurally complex molecules has become a real challenge among the synthetic community"--