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Domino Reactions In Drug Discovery

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Domino Reactions in Drug Discovery

Domino Reactions in Drug Discovery Book
Author : Shanta Bhar
Publisher : Elsevier
Release : 2020-10
ISBN : 9780128193747
Language : En, Es, Fr & De

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Book Description :

Domino Reactions in Drug Discovery presents a concise selection of domino reactions employed in routes for the synthesis of pharmaceuticals, agrochemicals and the design of new drug candidates. These versatile reactions play an important and integral part in both the aesthetic appeal and functional aspects of strategic drug discovery, lending enhanced efficiency and synthetic versatility to pharmaceutical drug design. Due to their atom economy, these reactions are increasingly popular in the development of complex scaffolds and multifunctional derivatives aimed at the synthesis of new chemical entities and approved APIs across diverse therapeutic classes, including antidiabetics [DPP4 inhibitors], anticancer therapies and HIV integrase inhibitors. Features illustrated schemes with mechanisms, procedures and results Includes a compendium of Domino Name Reactions for drugs Provides a concise, comprehensive coverage of domino reactions in drug discovery, with a focus on sustainable practices

Domino Reactions

Domino Reactions Book
Author : Lutz F. Tietze
Publisher : John Wiley & Sons
Release : 2013-12-23
ISBN : 3527671323
Language : En, Es, Fr & De

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Book Description :

The follow-up to the successful "Domino Reaction in Organic Synthesis", this ready reference brings up to date on the original concept. The chapters have been arranged according to the name of well-known transformations of the first step and in combination with the formed products. Each chapter is written by an internationally renowned expert, and the book is edited by L. F. Tietze, who established the concept of domino reactions. The one-stop source for all synthetic chemists to improve the synthetic efficiency and allow an ecologically and economically beneficial preparation of every chemical compound.

Domino Reactions in Organic Synthesis

Domino Reactions in Organic Synthesis Book
Author : Lutz F. Tietze,Gordon Brasche,Kersten Gericke
Publisher : John Wiley & Sons
Release : 2006-12-13
ISBN : 3527608680
Language : En, Es, Fr & De

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Book Description :

Domino reactions enable you to build complex structures in one-pot reactions without the need to isolate intermediates- a dream comes true. In this book, the well-respected expert, Professor Lutz Tietze, summarizes the possibilities of this reaction type - an approach for an efficiant, economically benificial and ecological benign synthesis. A definite must for every organic chemist.

Asymmetric Domino Reactions

Asymmetric Domino Reactions Book
Author : Helene Pellissier
Publisher : Royal Society of Chemistry
Release : 2013-03-13
ISBN : 184973710X
Language : En, Es, Fr & De

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Book Description :

This book covers the latest developments in asymmetric domino reactions, focussing on those published in the last 6 years. These fascinating reactions have rapidly become one of the most current fields in organic chemistry, since they allow reaching easily high molecular complexity in an economically favourable way with advantages of savings in solvent, time, energy, and costs. Unsurprisingly, the high levels of efficiency and enantioselectivity generally reached in these reactions have been exploited for the production of a wide number of complex chiral molecules with dense stereochemistry and functionality, which are motifs present in biologically active compounds and natural products. The book is divided into three principal sections, dealing successively with asymmetric domino reactions based on the use of chiral auxiliaries, asymmetric domino reactions based on the use of chiral metal catalysts, and asymmetric domino reactions based on the use of chiral organocatalysts, covering the literature since the beginning of 2006.

Privileged Structures in Drug Discovery

Privileged Structures in Drug Discovery Book
Author : Larry Yet
Publisher : John Wiley & Sons
Release : 2018-03-07
ISBN : 1118686357
Language : En, Es, Fr & De

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Book Description :

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book describes the up-to-date and state-of-the-art methods of organic synthesis that describe the use of privileged structures that are of most interest. Chapters included information on benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines, 2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen as privileged scaffolds in medicinal chemistry. Numerous, illustrative case studies document the current use of the privileged structures in the discovery of drugs. This important volume: Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them Offers the experience from an author who has worked in many therapeutic areas of medicinal chemistry Details many of the recent developments in organic chemistry that prepare target molecules Includes a wealth of medicinal chemistry case studies that clearly illustrate the use of privileged structures Designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty, Privileged Structures in Drug Discovery offers a current guide to organic synthesis methods to access the privileged structures of interest, and contains medicinal chemistry case studies that document their application.

Diversity Oriented Synthesis

Diversity Oriented Synthesis Book
Author : Andrea Trabocchi
Publisher : John Wiley & Sons
Release : 2013-06-17
ISBN : 1118618149
Language : En, Es, Fr & De

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Book Description :

Discover an enhanced synthetic approach to developing andscreening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developinglarge collections of structurally diverse small molecules as probesto investigate biological pathways. This book presents the mosteffective methods in diversity-oriented synthesis for creatingsmall molecule collections. It offers tested and proven strategiesfor developing diversity-oriented synthetic libraries and screeningmethods for identifying ligands. Lastly, it explores some promisingnew applications based on diversity-oriented synthesis that havethe potential to dramatically advance studies in drug discovery andchemical biology. Diversity-Oriented Synthesis begins with an introductorychapter that explores the basics, including a discussion of therelationship between diversity-oriented synthesis and classiccombinatorial chemistry. Divided into four parts, the book: Offers key chemical methods for the generation of smallmolecules using diversity-oriented principles, includingpeptidomimetics and macrocycles Expands on the concept of diversity-oriented synthesis bydescribing chemical libraries Provides modern approaches to screening diversity-orientedsynthetic libraries, including high-throughput and high-contentscreening, small molecule microarrays, and smart screeningassays Presents the applications of diversity-oriented syntheticlibraries and small molecules in drug discovery and chemicalbiology, reporting the results of key studies and forecasting therole of diversity-oriented synthesis in future biomedicalresearch This book has been written and edited by leading internationalexperts in organic synthesis and its applications. Theircontributions are based on a thorough review of the currentliterature as well as their own firsthand experience developingsynthetic methods and applications. Clearly written and extensively referenced,Diversity-Oriented Synthesis introduces novices to thishighly promising field of research and serves as a springboard forexperts to advance their own research studies and develop newapplications.

Multicomponent Reactions

Multicomponent Reactions Book
Author : Jieping Zhu,Hugues Bienaymé
Publisher : John Wiley & Sons
Release : 2006-03-06
ISBN : 3527604243
Language : En, Es, Fr & De

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Book Description :

In the very first book on this hot topic, the expert editors andauthors present a comprehensive overview of these elegantreactions. From the contents: Organoboron compounds Free-radical mediated multicomponent coupling reactions Applications in drug discovery Metal catalyzed reactions Total synthesis of natural products Asymmetric isocyanide-based reactions The Biginelli reaction Asymmetric isocyanide-based reactions The Domino-Knoevenagel-Hetero-Diels-Alder Reaction and relatedtransformations Catalytic asymmetric reactions Algorithm based methods for discovering novel reactions Post-condensation modifications of the Passerini and Ugireactions An essential reference for organic and catalytic chemists, andthose working in organometallics both in academia and industry.

Catalytic Cascade Reactions

Catalytic Cascade Reactions Book
Author : Peng-Fei Xu,Wei Wang
Publisher : John Wiley & Sons
Release : 2013-10-02
ISBN : 1118356632
Language : En, Es, Fr & De

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Book Description :

Demonstrates the advantages of catalytic cascade reactionsfor synthesizing natural products and pharmaceuticals Riding the wave of green chemistry, catalytic cascade reactionshave become one of the most active research areas in organicsynthesis. During a cascade reaction, just one reaction solvent,one workup procedure, and one purification step are needed, thussignificantly increasing synthetic efficiency. Featuring contributions from an international team of pioneersin the field, Catalytic Cascade Reactions demonstrates theversatility and application of these reactions for synthesizingvaluable compounds. The book examines both organocatalysis andtransition-metal catalysis reactions, bringing readers up to datewith the latest discoveries and activities in all major areas ofcatalytic cascade reaction research. Catalytic Cascade Reactions begins with three chaptersdedicated to organocatalytic cascade reactions, exploring amines,Brønsted acids, and the application of organocatalytic cascadereactions in natural product synthesis and drug discovery. Next,the book covers: Gold-catalyzed cascade reactions Cascade reactions catalyzed by ruthenium, iron, iridium,rhodium, and copper Palladium-catalyzed cascade reactions of alkenes, alkynes, andallenes Application of transition-metal catalyzed cascade reactions innatural product synthesis and drug discovery Engineering mono- and multifunctional nanocatalysts for cascadereactions Multiple-catalyst-promoted cascade reactions All chapters are thoroughly referenced, providing quick accessto important original research findings and reviews so that readerscan explore individual topics in greater depth. Drawing together and analyzing published findings scatteredacross the literature, this book provides a single source thatencapsulates our current understanding of catalytic cascadeprocesses. Moreover, it sets the stage for the development of newcatalytic cascade reactions and their applications.

Concepts and Case Studies in Chemical Biology

Concepts and Case Studies in Chemical Biology Book
Author : Herbert Waldmann,Petra Janning
Publisher : John Wiley & Sons
Release : 2014-06-30
ISBN : 3527676007
Language : En, Es, Fr & De

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Book Description :

Retaining the proven didactic concept of the successful "Chemical Biology - Learning through Case Studies", this sequel features 27 new case studies, reflecting the rapid growth in this interdisciplinary topic over the past few years. Edited by two of the world's leading researchers in the field, this textbook introduces students and researchers to the modern approaches in chemical biology, as well as important results, and the techniques and methods applied. Each chapter presents a different biological problem taken from everyday lab work, elucidated by an international team of renowned scientists. With its broad coverage, this is a valuable source of information for students, graduate students, and researchers working on the borderline between chemistry, biology, and biochemistry.

Medicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs Book
Author : Carmen Avendano,J. Carlos Menendez
Publisher : Elsevier
Release : 2008-06-04
ISBN : 9780080559629
Language : En, Es, Fr & De

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Book Description :

Antitumor chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumor drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, aiming at the rationalization of the action of this type of drug, which would allow the design of new active structures. * Explains the biological basis of cancer treatment and the role of chemists in improving anticancer drugs * Provides the historical background and serves as a comprehensive and practical guide on cancer research and anticancer drug development * Includes coverage of different approaches to treating cancer, drug resistance, and a chapter on cancer prevention

Trends in Drug Research II

Trends in Drug Research II Book
Author : H. van der Goot
Publisher : Elsevier
Release : 1998-01-16
ISBN : 9780080543246
Language : En, Es, Fr & De

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Book Description :

This volume of Pharmacochemistry Library comprises the text of invited lectures presented at the 11th Noordwijkerhout-Camerino Symposium Trends in Drug Research, held in Noordwijkerhout, The Netherlands, from 11-15 May 1997. In the programme attention has been given to the generation of new biological target systems and the generation of new lead molecules, with presentations on e.g. combinatorial chemistry, compound libraries, database search, high throughput screening and molecular biology. Other topics discussed were the perspectives for new medicines for the gastro-intestinal tract, the major developments in the search for effective anti-HIV drugs and new aspects in synthetic approaches. In a special session three topics which currently draw much attention were discussed: How to deal with the major problem of resistance against antimirobial agents? Can the apoptosis mechanism be used as a drug target? Is the newly observed phenomenon of inverse agonism a general principle and has it consequences for drug development (and use?)

The Way of Synthesis

The Way of Synthesis Book
Author : Tomas Hudlicky,Josephine W. Reed
Publisher : Wiley-VCH
Release : 2007-09-04
ISBN :
Language : En, Es, Fr & De

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Book Description :

This two-colored textbook presents not only synthetic ways to design organic compounds, it also contains a compilation of the most important total synthesis of the last 50 years with a comparative view of multiple designs for the same targets. It explains different tactics and strategies, making it easy to apply to many problems, regardless of the synthetic question in hand. Following a historical view of the evolution of synthesis, the book goes on to look at principles and issues impacting synthesis and design as well as principles and issues of methods. The sections on comparative design cover classics in terpenes and alkaloid synthesis, while a further section covers such miscellaneous syntheses as Maytansine, Palytoxin, Brevetoxin B and Indinavir. The whole is rounded off with a look at future perspectives and, what makes this textbook extraordinairy, with personal recollections of the chemists, who synthesized these fascinating compounds. With its attractive layout highlighting key parts and tactics using a second color, this is a useful tool for organic chemists, lecturers and students in chemistry, as well as those working in the chemical industry. "I think, as will many organic chemists, that the Hudlicky book will be the Bible of synthetic organic chemistry, the past, the present and the future. A hallmark publication." (Victor Snieckus)

Synthesis of Heterocycles Via Multicomponent Reactions II

Synthesis of Heterocycles Via Multicomponent Reactions II Book
Author : Romano V. A. Orru,Eelco Ruijter
Publisher : Springer Science & Business Media
Release : 2010-09-05
ISBN : 3642154549
Language : En, Es, Fr & De

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Book Description :

Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery

Reactions and Syntheses

Reactions and Syntheses Book
Author : Lutz F. Tietze,Theophil Eicher,Ulf Diederichsen,Andreas Speicher,Nina Schützenmeister
Publisher : John Wiley & Sons
Release : 2015-06-22
ISBN : 3527338144
Language : En, Es, Fr & De

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Book Description :

"The second edition of this classic text book has been completely revised, updated, and extended to include chapters on biomimetic amination reactions, Wacker oxidation, and useful domino reactions. The first-class author team with long-standing experience in practical courses on organic chemistry covers a multitude of preparative procedures of reaction types and compound classes indispensable in modern organic synthesis. Throughout, the experiments are accompanied by the theoretical and mechanistic fundamentals, while the clearly structured sub-chapters provide concise background information, retrosynthetic analysis, information on isolation and purification, analytical data as well as current literature citations. Finally, in each case the synthesis is labeled with one of three levels of difficulty. An indispensable manual for students and lecturers in chemistry, organic chemists, as well as lab technicians and chemists in the pharmaceutical and agrochemical industries."--P. [4] of cover.

Directory of Graduate Research

Directory of Graduate Research Book
Author : American Chemical Society. Committee on Professional Training
Publisher :
Release : 2005
ISBN :
Language : En, Es, Fr & De

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Book Description :

Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.

Reactive Intermediates in Organic Chemistry

Reactive Intermediates in Organic Chemistry Book
Author : Maya Shankar Singh
Publisher : John Wiley & Sons
Release : 2014-01-22
ISBN : 3527678271
Language : En, Es, Fr & De

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Book Description :

Most reactions in organic chemistry do not proceed in a single step but rather take several steps to yield the desired product. In the course of these multi-step reaction sequences, short-lived intermediates can be generated that quickly convert into other intermediates, reactants, products or side products. As these intermediates are highly reactive, they cannot usually be isolated, but their existence and structure can be proved by theoretical and experimental methods. Using the information obtained, researchers can better understand the underlying reaction mechanism of a certain organic transformation and thus develop novel strategies for efficient organic synthesis. The chapters are clearly structured and are arranged according to the type of intermediate, providing information on the formation, characterization, stereochemistry, stability, and reactivity of the intermediates. Additionally, representative examples and a problem section with different levels of difficulty are included for self-testing the newly acquired knowledge. By providing a deeper understanding of the underlying concepts, this is a musthave reference for PhD and Master Students in organic chemistry, as well as a valuable source of information for chemists in academia and industry working in the field. It is also ideal as primary or supplementary reading for courses on organic chemistry, physical organic chemistry or analytical chemistry.