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Domino Reactions In Drug Discovery

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Domino Reactions in Drug Discovery

Domino Reactions in Drug Discovery Book
Author : Shanta Bhar
Publisher : Elsevier
Release : 2020-10
ISBN : 9780128193747
Language : En, Es, Fr & De

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Book Description :

Domino Reactions in Drug Discovery presents a concise selection of domino reactions employed in routes for the synthesis of pharmaceuticals, agrochemicals and the design of new drug candidates. These versatile reactions play an important and integral part in both the aesthetic appeal and functional aspects of strategic drug discovery, lending enhanced efficiency and synthetic versatility to pharmaceutical drug design. Due to their atom economy, these reactions are increasingly popular in the development of complex scaffolds and multifunctional derivatives aimed at the synthesis of new chemical entities and approved APIs across diverse therapeutic classes, including antidiabetics [DPP4 inhibitors], anticancer therapies and HIV integrase inhibitors. Features illustrated schemes with mechanisms, procedures and results Includes a compendium of Domino Name Reactions for drugs Provides a concise, comprehensive coverage of domino reactions in drug discovery, with a focus on sustainable practices

Synthesis of Aromatic Heterocycles by Palladium 0 catalyzed Domino Reactions and Cyclization of Hydrazone Dianions

Synthesis of Aromatic Heterocycles by Palladium 0  catalyzed Domino Reactions and Cyclization of Hydrazone Dianions Book
Author : Thang Ngoc Ngo
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Synthesis of Aromatic Heterocycles by Palladium 0 catalyzed Domino Reactions and Cyclization of Hydrazone Dianions book written by Thang Ngoc Ngo, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Multicomponent Reactions

Multicomponent Reactions Book
Author : Jieping Zhu,Hugues Bienaymé
Publisher : John Wiley & Sons
Release : 2006-03-06
ISBN : 3527604243
Language : En, Es, Fr & De

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Book Description :

In the very first book on this hot topic, the expert editors andauthors present a comprehensive overview of these elegantreactions. From the contents: Organoboron compounds Free-radical mediated multicomponent coupling reactions Applications in drug discovery Metal catalyzed reactions Total synthesis of natural products Asymmetric isocyanide-based reactions The Biginelli reaction Asymmetric isocyanide-based reactions The Domino-Knoevenagel-Hetero-Diels-Alder Reaction and relatedtransformations Catalytic asymmetric reactions Algorithm based methods for discovering novel reactions Post-condensation modifications of the Passerini and Ugireactions An essential reference for organic and catalytic chemists, andthose working in organometallics both in academia and industry.

Domino Reactions in Organic Synthesis

Domino Reactions in Organic Synthesis Book
Author : Lutz F. Tietze,Gordon Brasche,Kersten Gericke
Publisher : John Wiley & Sons
Release : 2006-12-13
ISBN : 3527608680
Language : En, Es, Fr & De

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Book Description :

Domino reactions enable you to build complex structures in one-pot reactions without the need to isolate intermediates- a dream comes true. In this book, the well-respected expert, Professor Lutz Tietze, summarizes the possibilities of this reaction type - an approach for an efficiant, economically benificial and ecological benign synthesis. A definite must for every organic chemist.

Privileged Structures in Drug Discovery

Privileged Structures in Drug Discovery Book
Author : Larry Yet
Publisher : John Wiley & Sons
Release : 2018-03-07
ISBN : 1118686357
Language : En, Es, Fr & De

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Book Description :

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book describes the up-to-date and state-of-the-art methods of organic synthesis that describe the use of privileged structures that are of most interest. Chapters included information on benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines, 2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen as privileged scaffolds in medicinal chemistry. Numerous, illustrative case studies document the current use of the privileged structures in the discovery of drugs. This important volume: Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them Offers the experience from an author who has worked in many therapeutic areas of medicinal chemistry Details many of the recent developments in organic chemistry that prepare target molecules Includes a wealth of medicinal chemistry case studies that clearly illustrate the use of privileged structures Designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty, Privileged Structures in Drug Discovery offers a current guide to organic synthesis methods to access the privileged structures of interest, and contains medicinal chemistry case studies that document their application.

Asymmetric Domino Reactions

Asymmetric Domino Reactions Book
Author : Helene Pellissier
Publisher : Royal Society of Chemistry
Release : 2013-03-13
ISBN : 184973710X
Language : En, Es, Fr & De

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Book Description :

This book covers the latest developments in asymmetric domino reactions, focussing on those published in the last 6 years. These fascinating reactions have rapidly become one of the most current fields in organic chemistry, since they allow reaching easily high molecular complexity in an economically favourable way with advantages of savings in solvent, time, energy, and costs. Unsurprisingly, the high levels of efficiency and enantioselectivity generally reached in these reactions have been exploited for the production of a wide number of complex chiral molecules with dense stereochemistry and functionality, which are motifs present in biologically active compounds and natural products. The book is divided into three principal sections, dealing successively with asymmetric domino reactions based on the use of chiral auxiliaries, asymmetric domino reactions based on the use of chiral metal catalysts, and asymmetric domino reactions based on the use of chiral organocatalysts, covering the literature since the beginning of 2006.

Medicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs Book
Author : Carmen Avendano,J. Carlos Menendez
Publisher : Elsevier
Release : 2015-06-11
ISBN : 0444626670
Language : En, Es, Fr & De

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Book Description :

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Small Molecule Drug Discovery

Small Molecule Drug Discovery Book
Author : Andrea Trabocchi,Elena Lenci
Publisher : Elsevier
Release : 2019-11-23
ISBN : 0128183500
Language : En, Es, Fr & De

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Book Description :

Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases. The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology. Outlines modern concepts and synthetic strategies underlying the building of small molecules and their chemical libraries useful for drug discovery Provides modern biophysical methods to screening small molecule libraries, including high-throughput screening, small molecule microarrays, phenotypic screening and chemical genetics Presents the most advanced chemoinformatics tools to characterize the structural features of small molecule libraries in terms of chemical diversity and complexity, also including the application of virtual screening approaches Gives an overview of structural features and classification of natural product-derived small molecules, including carbohydrate derivatives, peptides and peptidomimetics, and alkaloid-inspired small molecules

Diversity Oriented Synthesis

Diversity Oriented Synthesis Book
Author : Andrea Trabocchi
Publisher : John Wiley & Sons
Release : 2013-06-17
ISBN : 1118618149
Language : En, Es, Fr & De

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Book Description :

Discover an enhanced synthetic approach to developing andscreening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developinglarge collections of structurally diverse small molecules as probesto investigate biological pathways. This book presents the mosteffective methods in diversity-oriented synthesis for creatingsmall molecule collections. It offers tested and proven strategiesfor developing diversity-oriented synthetic libraries and screeningmethods for identifying ligands. Lastly, it explores some promisingnew applications based on diversity-oriented synthesis that havethe potential to dramatically advance studies in drug discovery andchemical biology. Diversity-Oriented Synthesis begins with an introductorychapter that explores the basics, including a discussion of therelationship between diversity-oriented synthesis and classiccombinatorial chemistry. Divided into four parts, the book: Offers key chemical methods for the generation of smallmolecules using diversity-oriented principles, includingpeptidomimetics and macrocycles Expands on the concept of diversity-oriented synthesis bydescribing chemical libraries Provides modern approaches to screening diversity-orientedsynthetic libraries, including high-throughput and high-contentscreening, small molecule microarrays, and smart screeningassays Presents the applications of diversity-oriented syntheticlibraries and small molecules in drug discovery and chemicalbiology, reporting the results of key studies and forecasting therole of diversity-oriented synthesis in future biomedicalresearch This book has been written and edited by leading internationalexperts in organic synthesis and its applications. Theircontributions are based on a thorough review of the currentliterature as well as their own firsthand experience developingsynthetic methods and applications. Clearly written and extensively referenced,Diversity-Oriented Synthesis introduces novices to thishighly promising field of research and serves as a springboard forexperts to advance their own research studies and develop newapplications.

Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience

Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience Book
Author : Zbigniew J. Witczak,Roman Bielski
Publisher : John Wiley & Sons
Release : 2016-01-14
ISBN : 1119044391
Language : En, Es, Fr & De

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Book Description :

The book consists of a brief introduction, a foreward provided byprofessor Danishefsky of Columbia University, and about 14 –16 chapters, each written by one or two eminent scholars/authorsdescribing their recent research in the area of either dominoreactions or intramolecular rearrangements in carbohydratechemistry. Three or four chapters will be reviews. The domino (cascade, tandem)reactions are always intramolecular. They are usually very fast,clean and offer highly complex structures in a one pot process.Intramolecular rearrangements offer very similar advantages andoften lead to highly complex products as well. Although manyrecently isolated carbohydrates fulfill various sophisticatedfunctions, their structures are often very complex. The editorscover the broadest scope of novel methodologies possible. All thesynthetic and application aspects of domino/cascade reactions areexplored in this book. A second theme that will be covered isintramolecular rearrangement, which is also fast, stereoselective,and often constitutes one or more steps of domino /cascade process.Selected examples of intramolecular rearrangements are presented.Together, both processes offer an elegant and convenient approach to the synthesis of many complex molecules,which are normally difficult to synthesize via alternative routes.It appears that domino and intramolecular rearrangements areideally suited to synthesize certain specific modifiedmonosaccharides. What is particularly important is that bothprocesses are intermolecular and almost always yield products withvery well-defined stereochemistry. This high definition isabsolutely crucial when synthesizing advanced, modified mono andoligosaccharides. The choice of contributors reflects anemphasis on both therapeutic and pharmacological aspects of carbohydratechemistry.

Synthesis of Heterocycles via Multicomponent Reactions II

Synthesis of Heterocycles via Multicomponent Reactions II Book
Author : Romano V. A. Orru,Eelco Ruijter
Publisher : Springer
Release : 2010-07-26
ISBN : 3642154557
Language : En, Es, Fr & De

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Book Description :

Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery

Drug Discovery and Development

Drug Discovery and Development Book
Author : Ramarao Poduri
Publisher : Springer Nature
Release : 2021-09-20
ISBN : 9811555346
Language : En, Es, Fr & De

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Book Description :

Download Drug Discovery and Development book written by Ramarao Poduri, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Aromatic Polycyclic Hydrocarbons Advances in Research and Application 2013 Edition

Aromatic Polycyclic Hydrocarbons   Advances in Research and Application  2013 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2013-06-21
ISBN : 1481685260
Language : En, Es, Fr & De

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Book Description :

Aromatic Polycyclic Hydrocarbons—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Naphthalenes. The editors have built Aromatic Polycyclic Hydrocarbons—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Naphthalenes in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Aromatic Polycyclic Hydrocarbons—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Innovations in Green Chemistry and Green Engineering

Innovations in Green Chemistry and Green Engineering Book
Author : Paul T. Anastas,Julie B. Zimmerman
Publisher : Springer Science & Business Media
Release : 2012-12-13
ISBN : 146145817X
Language : En, Es, Fr & De

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Book Description :

Processes that meet the objectives of green chemistry and chemical engineering minimize waste and energy use, and eliminate toxic by-products. Given the ubiquitous nature of products from chemical processes in our lives, green chemistry and chemical engineering are vital components of any sustainable future. Gathering together ten peer-reviewed articles from the Encyclopedia of Sustainability Science and Technology, Innovations in Green Chemistry and Green Engineering provides a comprehensive introduction to the state-of-the-art in this key area of sustainability research. Worldwide experts present the latest developments on topics ranging from organic batteries and green catalytic transformations to green nanoscience and nanotoxicology. An essential, one-stop reference for professionals in research and industry, this book also fills the need for an authoritative course text in environmental and green chemistry and chemical engineering at the upper-division undergraduate and graduate levels.

Solid Supported Combinatorial and Parallel Synthesis of Small Molecular Weight Compound Libraries

Solid Supported Combinatorial and Parallel Synthesis of Small Molecular Weight Compound Libraries Book
Author : D. Obrecht,J.M. Villalgordo
Publisher : Elsevier
Release : 1998-10-02
ISBN : 0080517366
Language : En, Es, Fr & De

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Book Description :

The words "Combinatorial Chemistry" have different meanings to different people, ranging from split and mix strategies to parallel synthesis using robots, and embracing the whole range of preparative chemistry from organic molecules, to catalyst ligands, and even inorganic solids. All of these activities have in common an attempt to expand the diversity of structure available to the chemist as well as the access to this diversity, permitting the discovery of new and valuable biological acid material properties. In this outstanding survey of combinatorial organic chemistry, the authors, Obrecht who has established a new combinatorial chemistry company called Polyphor, and Villalgardo have brought together the literature, including that from 1998, and have concisely analysed the applications and achievements of this new field. This work will be of value to all chemists engaged in preparative work, both in industry and academe.

Rhodium Catalysis

Rhodium Catalysis Book
Author : Carmen Claver
Publisher : Springer
Release : 2017-12-15
ISBN : 3319666657
Language : En, Es, Fr & De

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Book Description :

The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics of pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors. All chapters from Topics in Organometallic Chemistry are published OnlineFirst with an individual DOI. In references, Topics in Organometallic Chemistry is abbrev iated as Top Organomet Chem and cited as a journal.

New Approaches to Drug Discovery

New Approaches to Drug Discovery Book
Author : Ulrich Nielsch,Ulrike Fuhrmann,Stefan Jaroch
Publisher : Springer
Release : 2016-03-30
ISBN : 3319289144
Language : En, Es, Fr & De

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Book Description :

This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technologies to identify new small molecules as lead compounds for further optimization; in a second section the technologies to identify biologics as leads are addressed. The final part focuses on the pharmacological models and technologies to characterize new compounds and the impact of biomarkers to facilitate the transfer of drug candidates into the development phase.

Asymmetric Metal Catalysis in Enantioselective Domino Reactions

Asymmetric Metal Catalysis in Enantioselective Domino Reactions Book
Author : Helene Pellissier
Publisher : John Wiley & Sons
Release : 2019-08-02
ISBN : 3527822518
Language : En, Es, Fr & De

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Book Description :

Introduces an innovative and outstanding tool for the easy synthesis of complex chiral structures in a single step Covering all of the literature since the beginning of 2006, this must-have book for chemists collects the major progress in the field of enantioselective one-, two-, and multicomponent domino reactions promoted by chiral metal catalysts. It clearly illustrates how enantioselective metal-catalyzed processes constitute outstanding tools for the development of a wide variety of fascinating one-pot asymmetric domino reactions, thereby allowing many complex products to be easily generated from simple materials in one step. The book also strictly follows the definition of domino reactions by Tietze as single-, two-, as well as multicomponent transformations. Asymmetric Metal Catalysis in Enantioselective Domino Reactions is divided into twelve chapters, dealing with enantioselective copper-, palladium-, rhodium-, scandium-, silver-, nickel-, gold-, magnesium-, cobalt-, zinc-, yttrium and ytterbium-, and other metal-catalyzed domino reactions. Most of the chapters are divided into two parts dealing successively with one- and two-component domino reactions, and three-component processes. Each part is subdivided according to the nature of domino reactions. Each chapter of the book includes selected applications of synthetic methodologies to prepare natural and biologically active products. -Presents the novel combination of asymmetric metal catalysis with the concept of fascinating domino reactions, which allows high molecular complexity with a remarkable level of enantioselectivity -Showcases an incredible tool synthesizing complex and diverse chiral structures in a single reaction step -Includes applications in total synthesis of natural products and biologically active compounds -Written by a renowned international specialist in the field -Stimulates the design of novel asymmetric domino reactions and their use in the synthesis of natural products, pharmaceuticals, agrochemicals, and materials Asymmetric Metal Catalysis in Enantioselective Domino Reactions will be of high interest to synthetic, organic, medicinal, and catalytic chemists in academia and R&D departments.

Multicomponent Reactions

Multicomponent Reactions Book
Author : Raquel P. Herrera,Eugenia Marqués-López
Publisher : John Wiley & Sons
Release : 2015-03-30
ISBN : 111886400X
Language : En, Es, Fr & De

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Book Description :

Addressing a dynamic aspect of organic chemistry, this bookdescribes synthetic strategies and applications for multicomponentreactions – including key routes for synthesizing complexmolecules. • Illustrates the crucial role and theimportant utility of multicomponent reactions (MCRs) to organicsyntheses • Compiles novel and efficient syntheticmulticomponent procedures to give readers a complete picture ofthis class of organic reactions • Helps readers to design efficient andpractical transformations using multicomponent reactionstrategies • Describes reaction background,applications to synthesize complex molecules and drugs, andreaction mechanisms

Recent Advances in Applications of Name Reactions in Multicomponent Reactions

Recent Advances in Applications of Name Reactions in Multicomponent Reactions Book
Author : Majid M. Heravi,Vahideh Zadsirjan
Publisher : Elsevier
Release : 2020-05-29
ISBN : 0128196955
Language : En, Es, Fr & De

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Book Description :

Recent Advances in Applications of Name Reactions in Multicomponent Reactions is an ideal reference for researchers and postgraduate students studying organic chemistry, as well as synthetic organic chemists working on the development of novel methodologies for the synthesis of various heterocyclic systems, especially drug design and discovery, in both academia and industry. The book reviews recent applications of name reactions in multicomponents for the synthesis of heterocycles and examines recent advances in applications of significant name reactions, such as Ugi and Passirini, Click, Knoevenagel, Michael, Diels-Alder, Aldol, Mannich, Heck, Huisgen, and Suzuki in MCRs. These reactions can be used in the synthesis of a wide variety of novel heterocycles with different sizes and heteroatoms, as well as in the total synthesis of natural products in order to decrease the number of synthetic steps. Since chiral inductions are necessary for most of these sequential name reactions, their asymmetric catalyzed reactions are also described. Includes the synthesis of many heterocycles, which is ideal for synthetic organic chemists engaged in the synthesis of heterocyclic systems Covers the recent advances of asymmetric synthesis of a wide range of heterocycles in satisfactory enantioselectivities (ees) or distereoselectivities (des) Reviews the synthesis of a wide variety of interesting heterocycles by using a combination of different and versatile name reactions via MCRs