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Dna Repair In Cancer Therapy

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DNA Repair in Cancer Therapy

DNA Repair in Cancer Therapy Book
Author : Mark R. Kelley,Melissa L. Fishel
Publisher : Academic Press
Release : 2016-06-07
ISBN : 0128035994
Language : En, Es, Fr & De

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Book Description :

DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs. Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors. Provides a comprehensive overview of the basic and translational research in DNA repair as a cancer therapeutic target Includes timely updates from the earlier edition, including Fanconi Anemia cross-link repair, translesion DNA polymerases, chemotherapy induced peripheral neuropathy, and many other new areas within DNA repair and cancer therapy Saves academic, medical, and pharma researchers time by allowing them to quickly access the very latest details on DNA repair and cancer therapy Assists researchers and research clinicians in understanding the importance of the breakthroughs that are contributing to advances in disease-specific research

DNA Repair and Cancer

DNA Repair and Cancer Book
Author : Srinivasan Madhusudan,David M. Wilson III
Publisher : CRC Press
Release : 2013-01-22
ISBN : 1466577444
Language : En, Es, Fr & De

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Book Description :

DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topics include carcinogenesis as a predictive and/or prognostic biomarker for cancer therapy, nucleotide excision repair, and tumor genetics and personalized medicine. The contributions provide essential information to scientists, pharmaceutical investigators, and clinicians interested in cancer therapy.

DNA Repair Genetic Instability and Cancer

DNA Repair  Genetic Instability  and Cancer Book
Author : Anonim
Publisher : Unknown
Release : 2022-12-06
ISBN : 9814477117
Language : En, Es, Fr & De

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Book Description :

Download DNA Repair Genetic Instability and Cancer book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Targeting the DNA Damage Response for Anti Cancer Therapy

Targeting the DNA Damage Response for Anti Cancer Therapy Book
Author : John Pollard,Nicola Curtin
Publisher : Springer
Release : 2018-05-26
ISBN : 3319758365
Language : En, Es, Fr & De

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Book Description :

Over the past decade a complex role for DNA damage response (DDR) in tumorigenesis has emerged. A proficient DDR has been shown to be a primary cause for cellular resistance to the very many DNA damaging drugs, and IR, that are widely used as standard-of-care across multiple cancer types. It has also been shown that defects in this network, predominantly within the ATM mediated signaling pathway, are commonly observed in cancers and may be a primary event during tumorigenesis. Such defects may promote a genomically unstable environment, facilitating the persistence of mutations, any of which may provide a growth or survival advantage to the developing tumor. In addition, these somatic defects provide opportunities to exploit a reliance on remaining repair pathways for survival, a process which has been termed synthetic lethality. As a result of all these observations there has been a great interest in targeting the DDR to provide anti-cancer agents that may have benefit as monotherapy in cancers with high background DNA damage levels or as a means to increase the efficacy of DNA damaging drugs and IR. In this book we will review a series of important topics that are of great interest to a broad range of academic, industrial and clinical researchers, including the basic science of the DDR, its role in tumorigenesis and in dictating response to DNA damaging drugs and IR. Additionally, we will focus on the several proteins that have been targeted in attempts to provide drug candidates, each of which appear to have quite distinct profiles and could represent very different opportunities to provide patient benefit.

New Research Directions in DNA Repair

New Research Directions in DNA Repair Book
Author : Clark Chen
Publisher : BoD – Books on Demand
Release : 2013-05-22
ISBN : 9535111140
Language : En, Es, Fr & De

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Book Description :

This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.

PARP Inhibitors for Cancer Therapy

PARP Inhibitors for Cancer Therapy Book
Author : Nicola J. Curtin,Ricky A. Sharma
Publisher : Humana Press
Release : 2015-06-13
ISBN : 3319141511
Language : En, Es, Fr & De

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Book Description :

PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors. PARP inhibitors are a group of pharmacological inhibitors that are a particularly good target for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited by PARPi. The “synthetic lethality” of PARPi is an exciting concept for cancer therapy and has led to a heightened activity in this area.

DNA Damage DNA Repair and Disease

DNA Damage  DNA Repair and Disease Book
Author : Miral Dizdaroglu,R Stephen Lloyd
Publisher : Royal Society of Chemistry
Release : 2020-11-19
ISBN : 1839162562
Language : En, Es, Fr & De

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Book Description :

The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.

DNA Repair in Cancer Therapy

DNA Repair in Cancer Therapy Book
Author : Mark R. Kelley
Publisher : Academic Press
Release : 2011-09-12
ISBN : 0123849993
Language : En, Es, Fr & De

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Book Description :

Mark R. Kelley

DNA Repair and Cancer

DNA Repair and Cancer Book
Author : Srinivasan Madhusudan,David M. Wilson III
Publisher : CRC Press
Release : 2013-01-22
ISBN : 1466577436
Language : En, Es, Fr & De

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Book Description :

DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topics include carcinogenesis as a predictive and/or prognostic biomarker for cancer therapy, nucleotide excision repair, and tumor genetics and personalized medicine. The contributions provide essential information to scientists, pharmaceutical investigators, and clinicians interested in cancer therapy.

The Role of DNA Repair Pathways in Resistance to Chemotherapy and Radiotherapy in Cancer

The Role of DNA Repair Pathways in Resistance to Chemotherapy and Radiotherapy in Cancer Book
Author : José Díaz-Chávez,Rosa Maria Bermudez-Cruz,David Y. Lee
Publisher : Frontiers Media SA
Release : 2022-04-29
ISBN : 2889760480
Language : En, Es, Fr & De

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Book Description :

Download The Role of DNA Repair Pathways in Resistance to Chemotherapy and Radiotherapy in Cancer book written by José Díaz-Chávez,Rosa Maria Bermudez-Cruz,David Y. Lee, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Advances in DNA Repair in Cancer Therapy

Advances in DNA Repair in Cancer Therapy Book
Author : Lawrence Panasci,Raquel Aloyz,Moulay Alaoui-Jamali
Publisher : Springer
Release : 2015-01-28
ISBN : 9781489993083
Language : En, Es, Fr & De

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Book Description :

​A comprehensive review of the recent developments in DNA repair research that have potential for translational applications. The book explains in detail the various biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK. The book captures-for both cancer researchers and oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.​

Nanodelivery of Novel Inhibitors of DNA Repair for Enhanced Cancer Therapy

Nanodelivery of Novel Inhibitors of DNA Repair for Enhanced Cancer Therapy Book
Author : Sams Mohammad Anowar Sadat
Publisher : Unknown
Release : 2021
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Targeting DNA repair enzymes has attracted much attention in recent years to overcome the therapeutic resistance in cancer therapy. Inhibition of DNA repair enzymes can be used to make cancer cells sensitive to the DNA damaging effect of ionizing radiation or chemotherapy. In addition, the downregulation or mutation of specific DNA repair enzymes and/or tumor suppressor proteins in cancer cells can make them particularly more sensitive to the inhibition of DNA repair, a process known as "synthetic lethality". Human polynucleotide kinase/phosphatase (PNKP) is a bifunctional DNA repair enzyme which phosphorylates DNA 5′-termini and dephosphorylates DNA 3′-termini that processes the ligation of damaged DNA termini. The inhibition of PNKP can make cancer cells more sensitive to DNA damage by ionizing radiation or Topoisomerase I inhibitors. Through siRNA library screening, a synthetic lethal partnership between loss of PNKP and tumor suppressor Phosphatase and TENsin homolog deleted on chromosome 10 (PTEN). This inspired development of several small molecule inhibitors of PNKP. These newly synthesized PNKP inhibitors are not water-soluble, therefore not injectable. My research aim was to develop delivery systems at nanometer size range that can target a small molecule inhibitor of PNKP, known as A83B4C63 to the tumor while reducing their access to normal tissues. The nanocarriers were fabricated from self-associating block copolymers based on poly(ethylene oxide) (PEO) and poly(caprolactone) (PEO-PCL) or a-benzyl carboxylate substituted poly(caprolactone), abbreviated as PEO-PBCL. The developed nanocarriers were used for the encapsulation of A83B4C63 alone or with the active metabolite of irinotecan, i.e., SN-38. The developed formulations were characterized for their average diameter, polydispersity, morphology, loading properties, release profiles as well as sensitization of cancer cells to SN38 and/or ionizing radiation both in vitro and in vivo. To identify the binding affinity between intracellular PNKP and A83B4C63, a novel biophysical assay known as Cellular Thermal Shift Assay (CETSA) was developed and used. Maximum tolerated dose of A83B4C63 formulated with the aid of Cremophor EL:Ethanol (CE) and nanocarrier formulations was investigated in healthy CD-1 mice. The performed biochemical toxicity and immune histochemical experiments demonstrated that the intravenous (IV) administration of A83B4C63 in nanocarriers or CE form was not toxic up to the maximum examined dose of 50 mg/kg dose, although the nanocarrier injection was tolerated better by mice. The in vivo anticancer activity of the above formulations was also determined in colorectal cancer xenografts in mice either in PTEN negative model as monotherapy or in wild type model in combination with radiation therapy using the Small Animal Radiation Research Platform (SARRP). The results provided evidence for the anticancer activity of nanocarrier formulation of A83B4C63 as monotherapy in PTEN deficient HCT116 xenografts in mice. Inhibition of tumor growth was also observed as a result of combination of A83B4C63 nanocarriers with radiation therapy in wild type PTEN+ HCT116 xenografts in mice. This contrasted with the CE formulation of the PNKP inhibitor that did not show any activity, in vivo. The superior activity of the nano-formulation of A83B4C63 over CE formulation was attributed to the enhanced distribution of the drug to tumor site by its nanocarrier. A synergistic effect was also observed when nanocarriers of A83B4C63 were combined with SN-38 or its nano-formulation in CRC models, in vitro. The outcomes of this thesis have demonstrated the great feasibility of nano-delivery of a novel inhibitor of DNA repair for CRC therapy either as a single drug in PTEN deficient form or in combination with DNA damaging therapeutics.

DNA Repair in Cancer Therapy

DNA Repair in Cancer Therapy Book
Author : Lawrence C. Panasci,Moulay A. Alaoui-Jamali
Publisher : Springer Science & Business Media
Release : 2004-03-19
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This volume is concerned with the hallmark “relapse” or “drug resistance” phenomena that face the practicing oncologist on a daily basis. It covers the increasing evidence that impaired expression/activity of at least some of the DNA repair proteins account for tumor cell resistance to particular therapeutic agents. DNA Repair Therapeutics summarizes timely in-depth reviews covering the latest developments that have potential for translational and clinical applications and represents the first volume dedicated to the translational aspect of DNA repair in the clinic.

Ubiquitination Governing DNA Repair

Ubiquitination Governing DNA Repair Book
Author : Effrossyni Boutou,Horst-Werner Stürzbecher
Publisher : BoD – Books on Demand
Release : 2018-08-01
ISBN : 1789235847
Language : En, Es, Fr & De

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Book Description :

DNA damage response (DDR) and lesion repair are vital processes ensuring genome integrity through various pathways depending mainly on the nature of DNA injury and cell cycle stage. DDR is finely regulated at many levels in co-ordination with other ongoing processes as is genome replication and cell cycle progression. Posttranslational modifications (PTMs), affecting both protein-protein and protein-DNA interactions, play a crucial role in finely tuning all processes involved in the restoration of genome lesions. Regarding damaged chromatin, PTMs serve in many cases as recruitment platforms for DNA repair mechanisms by facilitating binding sites or regulating interactions between involved proteins. Ubiquitination, the addition of ubiquitin moieties on a target protein, apart from controlling protein availability through degradation, is also involved, together with partner small ubiquitin-like modifier (SUMO), in controlling many pathways involved in DDR by modifying the structure-function relationship and thus interacting with partner molecules. The aim of this book is to cover a broad spectrum of current topics in ubiquitination and to a lesser extent SUMOylation involvement in regulation of DDR and repair in health and disease. This book is intended for pre- and postgraduate students and young scientists in this field. Members of both academic and research institutions, actively involved in the field, have described their current understanding of major mechanisms involved, highlighted key events, described ongoing applications in both developmental diseases and cancer and provided hints for future potential applications.

Cancer Therapeutics Targeting DNA Repair Pathways

Cancer Therapeutics  Targeting DNA Repair Pathways Book
Author : Amila Suraweera,James A. L. Brown,Martin Francis Lavin,Yi Chieh Lim
Publisher : Frontiers Media SA
Release : 2022-03-10
ISBN : 288974650X
Language : En, Es, Fr & De

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Book Description :

Download Cancer Therapeutics Targeting DNA Repair Pathways book written by Amila Suraweera,James A. L. Brown,Martin Francis Lavin,Yi Chieh Lim, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetic Cancer Therapy

Epigenetic Cancer Therapy Book
Author : Steven Gray
Publisher : Academic Press
Release : 2015-07-01
ISBN : 0128002247
Language : En, Es, Fr & De

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Book Description :

Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver). The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies, including the cancer epigenome atlas Discusses targeted isoform specific versus pan-specific inhibitors, a rational drug design approach to epigenetics relevant to pharmacoepigenetic clinical applications Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs

The Genetics of Cancer

The Genetics of Cancer Book
Author : B.A. Ponder,M.J. Waring
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 9401106770
Language : En, Es, Fr & De

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Book Description :

It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.

The Biology and Treatment of Cancer

The Biology and Treatment of Cancer Book
Author : Arthur B. Pardee,Gary S. Stein
Publisher : John Wiley & Sons
Release : 2011-09-20
ISBN : 1118208455
Language : En, Es, Fr & De

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Book Description :

Offers a broad audience a concise presentation of the most up-to-date knowledge about the biology and treatment of cancer Full coverage of cancer prevention and control Clear, thorough discussion of current and possible future therapies Edited by two of the most eminent and widely recognized scholars of cancer research and therapeutics in the world, with contributions from top researchers and clinicians from across North America

DNA Damage and Repair

DNA Damage and Repair Book
Author : A. Castellani
Publisher : Springer Science & Business Media
Release : 2013-03-09
ISBN : 1475750161
Language : En, Es, Fr & De

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Book Description :

The First International Congress on DNA Damage and Repair was held in Rome, Italy, July 12-17, 1987. It was organized by the Italian Com mission for Nuclear Alternative Energy Sources. The subject of DNA damage and repair involves almost all the fields ofbidogical sciences. Some of the more prominent ones include carcino genesis, photobiology, radiation biology, aging, enzymology, genetics, and molecular biology. These individual fields have their own interna tional meetings and although the meetings often have sessions devoted to DNA repair, they do not bring together a wide diversity of international workers in the field to exchange ideas. The purpose of the Congress was to facilitate such an exchange among scientists representing many fields of endeavor and many countries. The 37 manuscripts in this volume, presented by the invited spea kers during the four and half days of the Congress, encompass the field of DNA damage and repair. They cover biological systems ranging from mo lecules to humans and deal with damages and repair after treatment of cells with various types of radiations, chemicals, and exogenous and en dogenous oxidative damages. The Congress and its Proceedings are dedicated to two international leaders in the field of DNA damage and repair, Alexander Hollaender of the United States and Adriano Buzzati Traverso of Italy. Hollaender, who died in December 1986, was one of the first investigators to recognize the damage to DNA was important in cell killing and mutagenesis. His early work indicated that cells could recover from radiation injury.

Understanding Radiation Biology

Understanding Radiation Biology Book
Author : Kenneth Chadwick
Publisher : CRC Press
Release : 2019-11-15
ISBN : 1000733548
Language : En, Es, Fr & De

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Book Description :

This book provides a qualitative and quantitative exploration of the action of radiation on living matter which leads to a complete and coherent interpretation of radiation biology. It takes readers from radiation-induced molecular damage in the nucleus of the cell and links this damage to cellular effects such as cell killing, chromosome aberrations and mutations before exploring organ damage, organism lethality and cancer induction. It also deals with radiological protection concepts and the difficulties of predicting the dose–effect relationship for low-dose and dose rate radiation risk. The book ends with separate chapters dealing with the effects of UV light exposure and risk classification of chemical mutagens, both of which are derived by logical extensions of the radiation model. This book will provide the basic foundations of radiation biology for undergraduate and graduate students in medical physics, biomedical engineering, radiological protection, medicine, radiology and radiography. Features Presents a comprehensive insight into radiation action on living matter Contains important implications for radiological protection and regulations Provides analytical methods for applications in radiotherapy