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Discovery And Development Of Therapeutics From Natural Products Against Neglected Tropical Diseases

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Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases

Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases Book
Author : Goutam Brahmachari
Publisher : Elsevier
Release : 2019-04-15
ISBN : 0128157240
Language : En, Es, Fr & De

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Book Description :

Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more. In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases. Includes chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Draws together cutting-edge research advances in natural product chemistry that are targeted at neglected tropical diseases Highlights the future potential of natural products as sources of novel medicinal compounds against neglected tropical diseases

Neglected Tropical Diseases

Neglected Tropical Diseases Book
Author : David C. Swinney,Michael P. Pollastri
Publisher : John Wiley & Sons
Release : 2019-07-25
ISBN : 3527808647
Language : En, Es, Fr & De

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Book Description :

A drug discovery reference to the crippling tropical diseases that affect more than 1 billion people. Neglected Tropical Diseases is the first book of its kind to offer a guide that follows the World Health Organization?s list of neglected tropical diseases. The authors?all are experts on the topic?address the development of effective treatments for 12 crippling infectious diseases that affect almost 20% of the world?s popluation. The book includes information on the common approaches and the most important factors that lead to the development of new drugs for treating tropical diseases. Individual chapters review 12 neglected tropical diseases that are grouped by infectious agent, from viruses to bacteria to eukaryotic parasites. For each of these diseases, the book explains the unmet medical need and explores the current and potential drug discovery strategies. The book also includes information on potential drug compounds derived from natural products. This important book: -Ties together information from different sources for developing novel treatsments forneglected tropical diseases -Is aligned with WHO?s initiative to eradicate tropical diseases -Outlines current and potential drugs for treating tropical diseases -Provides a standard reference for the entire field Written for medicinal chemists, pharmaceutical chemists, pharmaceutical industry, virologists, parasitologists, and specialists on tropics medicine, Neglected Tropical Diseases offers an essential guide and a systematic reference for the development of successful treatments for 12 crippling infectious diseases.

Discovery and Development of Anti Breast Cancer Agents from Natural Products

Discovery and Development of Anti Breast Cancer Agents from Natural Products Book
Author : Goutam Brahmachari
Publisher : Elsevier
Release : 2021-06-24
ISBN : 0128212780
Language : En, Es, Fr & De

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Book Description :

Discovery and Development of Anti-Breast Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations. This volume in the Natural Products Drug Discovery series focuses on molecules of natural origin and their synthetic analogs that show promising potential to act as anti-breast cancer and chemotherapeutic agents. Combining foundational background information on cancer mechanisms with details of medicinal structures from natural products, this volume compiles the latest developments from across interdisciplinary fields. Discovery and Development of Anti-Breast Cancer Agents from Natural Products will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for breast cancer, highlighting a number of key structures from natural products and exploring possible future developments in the area. Highlights active agents from natural sources for development as novel anti-cancer agents Features contributions from active researchers and leading experts working in the field Includes foundational background information on both breast cancer mechanisms and natural product structures to support researchers from different disciplines

Marine Natural Products

Marine Natural Products Book
Author : Hiromasa Kiyota
Publisher : Springer Nature
Release : 2021-09-02
ISBN : 9811646376
Language : En, Es, Fr & De

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Book Description :

This book is a compilation of the latest achievements of leading researchers in marine natural products with extremely diverse structures and biological activities. It presents discussions of isolation, structure elucidation, biosynthesis, total synthesis, and biochemical properties of the compounds with characteristic structures such as macrolides, cyclic depsipeptides, alkaloids, and water-soluble heterocyclic low-molecular-weight compounds, from sponges, bacteria, cyanobacteria, flagellates, and other such organisms. The book especially focuses on heterocyclic natural products as a title in the book series, Topics in Heterocyclic Chemistry.

Ethnomedicine A Boon of Nature

Ethnomedicine  A Boon of Nature Book
Author : Dr. Keshamma E.,Narender Kumar
Publisher : Priya Lokare
Release : 2022-03-23
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Ethnic medicine is the evaluation or combination of medicines common in the face of biologically active mixtures of plants and organisms. It is practiced by different ethnic groups, especially those who readily accept Western orders, such as B. Indigenous groups. These customs often collaborate with insects in Africa, America, or worldwide. The term folk medicine is sometimes used interchangeably with traditional medicine. Ethnomedical research is interdisciplinary; in its investigation of conventional prescriptions, it applies ethnobotany and clinical human studies strategies. Frequently, the medication customs it studies are saved simply by oral practice. Regularly these practices establish critical connections with bugs also. Logical ethnomedical studies show either anthropological examination or medication disclosure research. Anthropological investigations look at the social insight and set of conventional medication. Ethnomedicine has been utilized as a beginning stage in drug disclosure, explicitly those using reverse pharmacological methods. Ethnic medicine is a term that refers to a wide range of medical care frameworks, plans, practices, beliefs, and treatment practices that result from the local social transformation of events. Ethnomedicine is also interpreted as examining these frameworks and procedures, rather than understanding them in an anthropological setting, rather than evaluating their adequacy using rational strategies. In any case, such medical care frameworks don't follow the design of present-day or Western medication. All things being equal, these medical care rehearses depend on the one-of-a-kind culture that has emerged from local and native gatherings of individuals. Ethnomedicine isn't restricted to the conspicuous things, such as utilizing native plants and fixings to treat the wiped out.

Wound Healing Research

Wound Healing Research Book
Author : Prasun Kumar,Vijay Kothari
Publisher : Springer Nature
Release : 2021-07-20
ISBN : 9811626774
Language : En, Es, Fr & De

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Book Description :

This book presents the latest knowledge on both the physiological and the microbiological aspects of wound healing. Fresh insights into the process of cutaneous wound healing are described, which involves tissue regeneration and repair processes consisting of a sequence of molecular and cellular events. The management of infected wounds is then discussed in detail, covering the roles of traditional medicine practices, novel anti-infective formulations, non-antibiotic approaches, and probiotic bacteria. A section devoted to the interdisciplinary approach to wound care addresses topics including in vitro and in vivo research models, the development of advanced wound dressings, tissue engineering, and the potential applications of bioscaffolds. The authors are all leading researchers in the field. This book is an attempt to showcase current research status and future directions in the area of wound-healing research, which must be of interest to a large group of readers and researchers interested in this field.

WIPO Re Search Advancing science for neglected tropical diseases malaria and tuberculosis

WIPO Re Search  Advancing science for neglected tropical diseases  malaria and tuberculosis Book
Author : World Intellectual Property Organization
Publisher : WIPO
Release : 2019-06-04
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This edition of the Global Challenges In Focus series takes an in-depth look at some of WIPO Re:Search’s most promising scientific collaborations and their potential impacts – as described by the researchers and organizations involved.

Discovery and Development of Drugs for Neglected Diseases Chagas Disease Human African Trypanosomiasis and Leishmaniasis

Discovery and Development of Drugs for Neglected Diseases  Chagas Disease  Human African Trypanosomiasis  and Leishmaniasis Book
Author : Gildardo Rivera,Navin B. Patel,Debasish Bandyopadhyay
Publisher : Frontiers Media SA
Release : 2021-12-20
ISBN : 2889717925
Language : En, Es, Fr & De

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Book Description :

Download Discovery and Development of Drugs for Neglected Diseases Chagas Disease Human African Trypanosomiasis and Leishmaniasis book written by Gildardo Rivera,Navin B. Patel,Debasish Bandyopadhyay, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug Discovery in Africa

Drug Discovery in Africa Book
Author : Kelly Chibale,Mike Davies-Coleman,Collen Masimirembwa
Publisher : Springer Science & Business Media
Release : 2012-08-09
ISBN : 3642281753
Language : En, Es, Fr & De

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Book Description :

Drug discovery originating in Africa has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threat to the health of people living in Africa. Compiled by leading African and international experts, this book presents the science and strategies of modern drug discovery. It explores how the use of natural products and traditional medicines can benefit from conventional drug discovery approaches, and proposes solutions to current technological, infrastructural, human resources, and economic challenges, which are presented when attempting to engage in full-scale drug discovery. Topics addressed are varied; from African medicinal plants to marine bioprospecting, pharmacogenetics and the use of nanotechnology. This book brings together for the first time a collection of strategies and techniques that need to be considered when developing drugs in an African setting. It is an unprecedented and truly international effort, highlighting the remarkable effort made so far in the area of drug discovery research by African scientists, and scientists from other parts of the world working on African health problems.

Advances in Medicinal Chemistry Research

Advances in Medicinal Chemistry Research Book
Author : Edeildo Ferreira Da Silva, Jr.
Publisher : Unknown
Release : 2019-10-15
ISBN : 9781536163681
Language : En, Es, Fr & De

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Book Description :

Advances in Medicinal Chemistry Research is a book addressed to undergraduate and postgraduate students, where recent advances in the discovery and development of effective agents against the most remarkable wide-reaching diseases are presented, divided into seven chapters. This first edition of Advances in Medicinal Chemistry Research offers insights into medicinal chemistry that arguably have the most significant impact on our lives than any other. It draws together research on therapeutic agents from natural, synthetic, and virtual screening sources as starting points for the design of drugs against obesity, multidrug-resistant bacteria, neglected tropical diseases, Alzheimer, and cancer. From the prediction of promising hits and identification of active compounds to the extraction of more complex molecules, this book explores a range of essential topics to support the development of novel, economical, and efficacious therapeutics for these diseases, which currently affect a billion people worldwide. Beginning with an overview of obesity, showing the current research landscape, the books shows the importance of natural and synthetic products as promising anti-obesity agents. Subsequently, the medicinal chemistry of modulation of bacterial resistance is presented, focusing on the MFS, RND, ABC, and MATE superfamilies. The book goes on to discuss such topics as antituberculosis, antileishmanial, and anti-hepatitis thiophene-containing compounds, under the medicinal chemistry point of view. Also, potent human glutaminyl cyclase inhibitors are deeply discussed and displayed as hopeful anti-Alzheimer's agents. The last three chapters are focused on the development of researches involving new anticancer agents, initializing with LBDD, SBDD, QSAR, and QM/MM methods applied to the identification of novel promising anticancer compounds. Moreover, IDO1 inhibitors are exhaustively explored and analyzed as a new promise for the immunotherapy of cancer. Finally, a great update on Eg5 kinesin inhibitors is provided, exploring different chemical classes of synthetic and natural compounds, including miscellanea as a new approach for Eg5 inhibition. Combining the expertise of researchers from around the world, this volume aims to support and encourage researches for the development of novel, safe, and active agents against lipase enzyme, bacteria, neglected tropical diseases, Alzheimer, and cancer. The clear narrative truly engages the reader, holding their attention right from the opening of a chapter, and maintaining interest and understanding as a chapter leads into more complex material. Advances in Medicinal Chemistry Research is a book that reviews ongoing developments and recent cutting-edge advances in medicinal chemistry of the most relevant diseases found nowadays, underlining how medicinal chemistry research continues to make significant contributions to the discovery and development of new therapeutic entities. Key Features â¢Chapters written by active specialists and leading experts deeply engaged in the research field of most deadly and limiting diseases for drug discovery. â¢Draws together cutting-edge research advances in medicinal chemistry focused at the obesity, multidrug-resistant microorganisms, Alzheimer, and cancer in a single volume. â¢Highlights the future potential of researches for the medicinal chemistry of most impactful diseases today. â¢Contents addressed to medicinal chemistry, biochemistry, biology, and pharmacy students, professors, and researchers.

Dermatophytes and Dermatophytoses

Dermatophytes and Dermatophytoses Book
Author : Jean-Philippe Bouchara,Pietro Nenoff,Aditya K. Gupta,Vishnu Chaturvedi
Publisher : Springer Nature
Release : 2021-06-08
ISBN : 3030674215
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive overview on the most recent knowledge in dermatophytic infection biology. Topics covered range from taxonomy, biology and genetics of most common skin disease causing fungi over immunology of dermatophytosis to diagnosis and treatment approaches. Furthermore epidemiology of skin diseases caused by pathogenic fungi is discussed. The book is aimed at researchers and advanced students in infection biology, microbiology and dermatology.

Characterization of New Marine Secondary Metabolites for the Treatment of Cancer and Neglected Tropical Diseases

Characterization of New Marine Secondary Metabolites for the Treatment of Cancer and Neglected Tropical Diseases Book
Author : Thomas Luke Simmons
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Small molecules from natural sources are vital to drug discovery by providing molecular diversity and novel chemical scaffolds for further pharmacological development. The emergence of multiple drug resistant pathogens and problems associated with natural product dereplication emphasize the continuing need for the discovery of new and relevant bioactive molecules for the treatment of human disease. This thesis describes the biological activity guided chemical investigation of several marine taxa with emphasis on the isolation and structure elucidation of new secondary metabolites with therapeutic efficacy against cancer and infectious disease. Chapter I introduces the context, rationale and background which form the foundation of the thesis research. Chapter II describes the bioactivity guided discovery of a new cancer compound from a Panamanian marine cyanobacterium Symploca sp. The linear tetrapeptide contains unusual and modified amino residues and exhibits sub-micromolar cancer toxicity with a classic antimitotic mechanism of action. Chapter III describes the discovery of DMMC a new cyclic depsipeptide isolated from a Fijian strain of Lyngbya majuscula. The antitumor effects displayed by this compound were very potent and selective for solid tumor cell lines. A linear analog of DMMC was generated during structure determination, this analog proved to maintain the exquisite and selective activity of the parent molecule. Chapter IV describes the discovery of the viridamides A and B from the cyanobacterium Oscillatoria nigro-viridis. Structure elucidation of these linear lipodepsipeptides revealed the presence of the novel 5-methoxydec-9-ynonic acid residue and subsequent biological evaluation indicated low micromolar efficacy against two species of disease causing protozoan pathogens. Chapter V describes the bioassay guided isolation and structure elucidation of kaviol A, a halogenated phenolic inhibitor of histone deacetylase (HDAC) from a Papua New Guinean strain of the green alga Boodlea sp. This unique C6-C4-C6 structure contains multiple sites of halogenations and inhibits six isoforms of class II HDAC enzymes with very low micromolar IC50 values. Chapter VI provides a conclusion of this thesis research.

Medicinal Plants

Medicinal Plants Book
Author : Mallappa Kumara Swamy,Jayanta Kumar Patra,Gudepalya Renukaiah Rudramurthy
Publisher : CRC Press
Release : 2019-05-10
ISBN : 0429522134
Language : En, Es, Fr & De

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Book Description :

This book details several important medicinal plants, their occurrence, plant compounds and their chemical structures, and pharmacological properties against various human diseases. It also gives information on isolation and structural elucidation of phytocompounds, bio-assays, metabolomic studies, and therapeutical applications of plant compounds.

Applications of Nanobiotechnology for Neglected Tropical Diseases

Applications of Nanobiotechnology for Neglected Tropical Diseases Book
Author : Fabio Rocha Formiga,Dr Inamuddin,Patricia Severino
Publisher : Academic Press
Release : 2021-02-20
ISBN : 0128211016
Language : En, Es, Fr & De

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Book Description :

Applications of Nanobiotechnology for Neglected Tropical Diseases describes recent advances in nanobiotechnology that can be applied to reducing the global disease burden of neglected tropical diseases (NTDs). The book explores the application of nanotechnology on the development of safe, effective, and reliable tools to prevent, diagnose, and treat NTDs. Furthermore, Applications of Nanobiotechnology for Neglected Tropical Diseases includes multidisciplinary content, combining knowledge from biochemistry, medicinal chemistry, material sciences, pharmacology, and pharmaceutics. The book is divided into three main parts, each outlining one major type of approach: (1) nano-based approaches for prevention, (2) nano-diagnostics and detection, and (3) nanotherapeutics. Each part contains chapters that delve into the different applications of the type of approach being presented in that part. A discussion of other approaches against NTD follows these three parts. This book is remarkable in its ability to encompass and thoroughly explain the latest techniques in nanobiotechnology, from basic research to patient-oriented investigation. Offers a broad overview of nanobiotechnology applied to the prevention, diagnostics, and treatment of NTDs Presents cutting-edge recent advances in nanobiotechnology, focusing on diseases reported by the World Health Organization’s NTDs Roadmap (e.g., leishmaniasis, malaria, schistosomiasis, filariasis, etc.) Provides a deep discussion about ground-breaking approaches designed to meet the medical needs of patients suffering from NTDs Gives examples of multidisciplinary investigations into NTDs, from research labs to clinics

Frontiers in Natural Product Chemistry Volume 4

Frontiers in Natural Product Chemistry  Volume 4 Book
Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
Release : 2018-10-08
ISBN : 1681087251
Language : En, Es, Fr & De

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Book Description :

Frontiers in Natural Product Chemistry is a book series devoted to publishing monographs that highlight important advances in natural product chemistry. The series covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substances derived from plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are also included in the series. The fourth volume of the series brings seven reviews covering these topics: -natural antiamoebic medicines, analgesics and antimalarials -essential oils and cognitive performance -cannabis and drug development -lectins in biosensors -brassinosteroids

Nanotechnology in Medicine

Nanotechnology in Medicine Book
Author : Mahendra Rai,Mrunali Patel,Rashmin Patel
Publisher : John Wiley & Sons
Release : 2021-12-20
ISBN : 1119769868
Language : En, Es, Fr & De

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Book Description :

Discover thorough insights into the toxicology of nanomaterials used in medicine In Nanotechnology in Medicine: Toxicity and Safety, an expert team of nanotechnologists delivers a robust and up-to-date review of current and future applications of nanotechnology in medicine with a special focus on neurodegenerative diseases, cancer, diagnostics, nano-nutraceuticals, dermatology, and gene therapy. The editors offer resources that address nanomaterial safety, which tends to be the greatest hurdle to obtaining the benefits of nanomedicine in healthcare. The book is a one-stop resource for recent and comprehensive information on the toxicological and safety aspects of nanotechnology used in human health and medicine. It provides readers with cutting-edge techniques for delivering therapeutic agents into targeted cellular compartments, cells, tissues, and organs by using nanoparticulate carriers. The book also offers methodological considerations for toxicity, safety, and risk assessment. Nanotechnology in Medicine: Toxicity and Safety also provides readers with: A thorough introduction to the nanotoxicological aspects of nanomedicine, including translational nanomedicine and nanomedicine personalization Comprehensive introductions to nanoparticle toxicity and safety, including selenium nanoparticles and metallic nanoparticles Practical discussions of nanotoxicology and drug delivery, including gene delivery using nanocarriers and the use of nanomaterials for ocular delivery applications In-depth examinations of nanotechnology ethics and the regulatory framework of nanotechnology and medicine Perfect for researchers, post-doctoral candidates, and specialists in the fields of nanotechnology, nanomaterials, and nanocarriers, Nanotechnology in Medicine: Toxicity and Safety will also prove to be an indispensable part of the libraries of nanoengineering, nanomedicine, and biopharmaceutical professionals and nanobiotechnologists.

National Institute of Allergy and Infectious Diseases NIH

National Institute of Allergy and Infectious Diseases  NIH Book
Author : Vassil St. Georgiev
Publisher : Springer Science & Business Media
Release : 2009-07-06
ISBN : 1603272976
Language : En, Es, Fr & De

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Book Description :

National Institute of Allergy and Infectious Diseases, NIH: Volume 2: Impact on Global Health covers the scientific aspects of the entire portfolio of NIAID, including microbiology and infectious disease, HIV/AIDS, and immunology and vaccines. All major diseases and the relevant immunology and vaccine development are described in detail. In addition, all major NIAID programs, initiatives, and clinical trials are discussed and illustrate the global involvement of NIAID in biomedical research and its impact on public health worldwide. By providing this information, the global scientific community will be able to access and benefit from these programs and initiatives.

Frontiers in Clinical Drug Research Anti Cancer Agents Volume 6

Frontiers in Clinical Drug Research   Anti Cancer Agents  Volume 6 Book
Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
Release : 2021-03-04
ISBN : 9811478414
Language : En, Es, Fr & De

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Book Description :

Frontiers in Clinical Drug Research - Anti-Cancer Agents is a book series intended for pharmaceutical scientists, postgraduate students and researchers seeking updated and critical information for developing clinical trials and devising research plans in anti-cancer research. Reviews in each volume are written by experts in medical oncology and clinical trials research and compile the latest information available on special topics of interest to oncology and pharmaceutical chemistry researchers. The sixth volume of the book features reviews on these topics: · Immunomodulating Agents in The Treatment of Acute Myeloid Leukemia · Potential Natural Products for Prostate Cancer Management · Inhibition of Key Protein-Protein Interactions by Small Molecules for Cancer Drug Design · Efficacy of Hepatic Arterial Infusion Chemotherapy (HAIC) For Advanced Hepatocellular Carcinoma · Targeting Cancer Stem Cells: Implications in Health and Disease

Africa and the Sustainable Development Goals

Africa and the Sustainable Development Goals Book
Author : Maano Ramutsindela,David Mickler
Publisher : Springer
Release : 2019-06-13
ISBN : 3030148572
Language : En, Es, Fr & De

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Book Description :

The book draws upon the expertise and international research collaborations forged by the Worldwide Universities Network Global Africa Group to critically engage with the intersection, in theory and practice, of the Sustainable Development Goals (SDGs) and Africa’s development agendas and needs. Further, it argues that – and demonstrates how – the SDGs should be understood as an aspirational blueprint for development with multiple meanings that are situated in dynamic and contested terrains. As the SDGs have substantial implications for development policy and resourcing at both the macro and micro levels, their relevance is not only context-specific but should also be assessed in terms of the aspirations and needs of ordinary citizens across the continent. Drawing on analyses and evidence from both the natural and social sciences, the book demonstrates that progress towards the SDGs must meet demands for improving human well-being under diverse and challenging socio-economic, political and environmental conditions. Examples include those from the mining industry, public health, employment and the media. In closing, it highlights how international collaboration in the form of research networks can enhance the production of critical knowledge on and engagement with the SDGs in Africa.