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Discovery And Development Of Neuroprotective Agents From Natural Products

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Discovery and Development of Neuroprotective Agents from Natural Products

Discovery and Development of Neuroprotective Agents from Natural Products Book
Author : Goutam Brahmachari
Publisher : Elsevier
Release : 2017-05-18
ISBN : 0128097698
Language : En, Es, Fr & De

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Book Description :

Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer’s disease, Parkinson’s disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs. Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab

Discovery and Development of Anti Inflammatory Agents from Natural Products

Discovery and Development of Anti Inflammatory Agents from Natural Products Book
Author : Goutam Brahmachari
Publisher : Natural Product Drug Discovery
Release : 2019-09
ISBN : 9780128169926
Language : En, Es, Fr & De

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Book Description :

Discovery and Development of Anti-Inflammatory Agents from Natural Products, the latest volume in the Natural Product Drug Discovery series, presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations, with this volume focusing on molecules of natural origin and their synthetic analogues that have the potential to act against the pathogens responsible for inflammatory diseases. All aspects of each are covered, including isolations and structure elucidations, in vitro and in vivo biological activity, synthetic optimization, investigations of pharmacodynamics and kinetics, and the structure-activity relationships of anti-inflammatory natural products. Written by active researchers and leading experts, this book brings together an overview of current discoveries and trends in this field. It will be a valuable resource for researchers working to discover promising leads for the development of pharmaceuticals in the prevention and treatment of anti-inflammatory diseases. Features contributions from active researchers and leading experts working in medicinal natural products and herbal formulations Includes recent, cutting-edge advances on medicinal natural products, along with preventative therapies for different kinds of inflammation-directed diseases Offers an authoritative source of information on the industrial application of natural products for medicinal purposes

Discovery and Development of Anti inflammatory Agents from Natural Products

Discovery and Development of Anti inflammatory Agents from Natural Products Book
Author : Goutam Brahmachari
Publisher : Elsevier
Release : 2019-07-11
ISBN : 0128169931
Language : En, Es, Fr & De

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Book Description :

Discovery and Development of Anti-inflammatory Agents from Natural Products, the latest volume in the Natural Product Drug Discovery series, presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations, with this volume focusing on molecules of natural origin and their synthetic analogues that have the potential to act against the pathogens responsible for inflammatory diseases. All aspects of each are covered, including isolations and structure elucidations, in vitro and in vivo biological activity, synthetic optimization, investigations of pharmacodynamics and kinetics, and the structure-activity relationships of anti-inflammatory natural products. Written by active researchers and leading experts, this book brings together an overview of current discoveries and trends in this field. It will be a valuable resource for researchers working to discover promising leads for the development of pharmaceuticals in the prevention and treatment of anti-inflammatory diseases. Features contributions from active researchers and leading experts working in medicinal natural products and herbal formulations Includes recent, cutting-edge advances on medicinal natural products, along with preventative therapies for different kinds of inflammation-directed diseases Offers an authoritative source of information on the industrial application of natural products for medicinal purposes

Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases

Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases Book
Author : Christophe Wiart
Publisher : Unknown
Release : 2014
ISBN : 9780123983732
Language : En, Es, Fr & De

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Book Description :

Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases is the second volume in the series, Pharmaceutical Leads from Medicinal Plants. This book includes key pharmacological and chemical evidence to support the selection of promising pre-clinical candidates for the treatment of neurodegenerative diseases. This important addition to the natural product and drug discovery literature contains the history, synonyms, medicinal uses, phytopharmacology, pre-clinical potential, and rationale for each plant selected. By providing critical evaluation of pharmacological data, mechanisms of action, and structural requirements for the development of future neuroprotective agents, this comprehensive reference is a beneficial resource for industry and academic scientists whose research focuses on neurodegenerative drug discovery and development. Incorporates compelling biological activity data and preclinical structure-activity relationships to help you choose promising lead molecules for further research Includes primary source references to the most recent natural product discoveries in the field of neuroprotection in order to promote new drug discovery in this area Contains detailed discussions of important neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease Each plant section includes a critical evaluation of pharmacological, chemical, and toxicological evidence to support the use of the compound in drug discovery research in neurodegeneration

Functional Molecules from Natural Sources

Functional Molecules from Natural Sources Book
Author : Stephen Wrigley
Publisher : Royal Society of Chemistry
Release : 2011
ISBN : 1847552595
Language : En, Es, Fr & De

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Book Description :

This book is based on the proceedings of the conference, Functional Molecules from Natural Sources, held at Magdalen College, Oxford, in July 2009.

Design of Hybrid Molecules for Drug Development

Design of Hybrid Molecules for Drug Development Book
Author : Michael Decker
Publisher : Elsevier
Release : 2017-04-05
ISBN : 0081011180
Language : En, Es, Fr & De

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Book Description :

Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria. With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders. Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied Compares the advantages and disadvantages of these compounds Includes the very latest developments, such as photoactivatable and photo-responsive drugs

Burger s Medicinal Chemistry and Drug Discovery Therapeutic agents

Burger s Medicinal Chemistry and Drug Discovery  Therapeutic agents Book
Author : Alfred Burger
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Burger s Medicinal Chemistry and Drug Discovery Therapeutic agents book written by Alfred Burger, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Unlisted Drugs

Unlisted Drugs Book
Author : Anonim
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Unlisted Drugs book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Molecular Insight of Drug Design

Molecular Insight of Drug Design Book
Author : Arli Aditya Parikesit
Publisher : BoD – Books on Demand
Release : 2018-08-29
ISBN : 1789236320
Language : En, Es, Fr & De

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Book Description :

The approaches in drug design are mainly comprised of these three multidisciplinary sciences. First, Bioinformatics has successfully gather biological data in form of biomolecular sequences, in order to construct knowledge on drug and vaccine design. It is of considerable importance for drug designers to comprehend the utilization of bioinformatics tools for resolving their research questions. Second, Nanotechnology has made possible the design and delivery of the nano-based drug. Third, Pharmaceutical Chemistry made it possible to investigate the adsorption, distribution, metabolism, and toxicology of the drug candidates in a fine-grained resolution.

Mini Reviews in Medicinal Chemistry

Mini Reviews in Medicinal Chemistry Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Mini Reviews in Medicinal Chemistry book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Role of Natural Herbs in Stroke Prevention and Treatment

Role of Natural Herbs in Stroke Prevention and Treatment Book
Author : Manzoor A. Mir
Publisher : Unknown
Release : 2015-12-01
ISBN : 9781634835558
Language : En, Es, Fr & De

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Book Description :

The field of stroke research continues to evolve, and better outcomes are possible and even likely. Over the last two decades, basic science research in the field of stroke has elucidated multiple pathways of cellular injury and repair after cerebral ischemia, resulting in the identification of several promising targets for neuroprotection. Prevention and treatment of cerebrovascular diseases has been one of the primary goals of neuroscience research but unfortunately, to date, no such safe preventive agents are available. There is an urgent need for agents that are pharmacologically safe, cost-effective, and immediately available with minimal side effects. Although a considerable amount of research has been invested into the development of novel treatments capable of protecting the brain from damage following stroke, but with limited success. Currently, the only drug approved for the treatment of ischemic stroke is recombinant tissue plasminogen activator (rtPA, alteplase), which has a limited time window for administration and increases the risk for subsequent hemorrhage. This book assesses the immunobiology of stroke, natural herbs and human brain interaction, current evidence for the efficacy of a range of readily available plant-based extracts and chemicals that may improve brain function. They are discussed in terms of how an increased understanding of the relationship between their ecological roles and CNS effects might further the field of natural, phytochemical drug discovery. Numerous neuroprotective treatments have been identified that show great promise in animal models of stroke. In this book, we have also highlighted the promising targets of neuroprotection and the natural products from traditional medicinal herbs that exhibit protective effects on ischemic brain injury. Further the authors discuss the individual herbs, herbal cocktails and the components from herbs in neuroprotection. The book contains many diagrams and tables with highlighting the role of various herbs and their components in neuroprotection. A separate chapter has been included regarding polyphenols in neuroprotection.

Comprehensive Medicinal Chemistry II Volume 1

Comprehensive Medicinal Chemistry II  Volume 1 Book
Author : Peter Kennewell
Publisher : Elsevier Science
Release : 2006-11-15
ISBN : 9780080445144
Language : En, Es, Fr & De

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Book Description :

This volume provides and educative and authoriative discussions on the drug discovery and development process. It is divided into ten sections and starts with personal recollections on the history and evolution of the drug discovery process. To illustrate the end result of the drug discovery process, a large chapter reviews the major drug introductions over 1993-2003. Subsequent chapters examine the impact of genomic technologies, new sources of drugs and alternatives to animal testing. The next section reviews the roles of enterprise and pharamaceuticals companies, venture capitalists and academic-industrial relations in the drug discovery process. Social and ethical issues are reviewed in the context of assessing health demands in developed, developing countries and also in relation to smaller scale diseases (orphan drugs). Two chapters then review the bioethical and ethical issues facing the pharmaceutical industry. The volume concludes with reviews on funding and regulartion and how intellectual property rights and patents are protected. With such a wide variety of topics this volume will appeal to both scientists and non-scientists who need to understand how and why the pharmaceutical industry works. * valuable content available from May 2009 as an individual volume * provides a global overview of the drug discovery process

The Search for Biological Active Agent s From Actinobacteria 2nd Edition

The Search for Biological Active Agent s  From Actinobacteria  2nd Edition Book
Author : Learn-Han Lee,Kok-Gan Chan,Jem Stach,Elizabeth M. H. Wellington,Bey-Hing Goh
Publisher : Frontiers Media SA
Release : 2020-03-27
ISBN : 2889636399
Language : En, Es, Fr & De

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Book Description :

There is a large market demand for new drugs. The existing chronic or common ailments without cures, development of new diseases with unknown causes, and the widespread existence of antibiotic-resistant pathogens, have driven this field of research further by looking at all potential sources of natural products. To date, microbes have made a significant contribution to the health and well-being of people globally. The discoveries of useful metabolites produced by microbes have resulted in a significant proportion of pharmaceutical products in today’s market. Therefore, the investigation and identification of bioactive compound(s) producing microbes is always of great interest to researchers. Actinobacteria are one of the most important and efficient groups of natural metabolite producers. Among the numerous genera, Streptomyces have been recognized as prolific producers of useful natural compounds, as they provide more than half of the naturally-occurring antibiotics isolated to-date and continue to emerge as the primary source of new bioactive compounds. Certainly, these potentials have attracted ample research interest and a wide range of biological activities have been subsequently screened by researchers with the utilization of different In vitro and In vivo model of experiments. Literature evidence has shown that a significant number of interesting compounds produced by Actinobacteria were exhibiting either strong anticancer or neuroprotective activity. The further in depth studies have then established the modulation of apoptotic pathway was involved in those observed bioactivities. These findings indirectly prove the biopharmaceutical potential possessed by Actinobacteria and at the same time substantiate the importance of diverse pharmaceutical evaluations on Actinobacteria. In fact, many novel compounds discovered from Actinobacteria with strong potential in clinical applications have been developed into new drugs by pharmaceutical companies. Together with the advancement in science and technology, it is predicted that there would be an expedition in discoveries of new bioactive compounds producing Actinobacteria from various sources, including soil and marine sources. In light of these current needs, and great interest in the scope of this research, this book seeks to contribute on the investigation of different biological active compound(s) producing actinobacteria which are exhibiting antimicrobial, antioxidant, neuroprotective, anticancer activities and similar.

Herbs for Diabetes and Neurological Disease Management

Herbs for Diabetes and Neurological Disease Management Book
Author : Vikas Kumar,Addepalli Veeranjaneyulu
Publisher : CRC Press
Release : 2018-01-02
ISBN : 1351801082
Language : En, Es, Fr & De

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Book Description :

This new volume provides a plethora of new information about potential medicinal herbs and their usefulness in treating diabetes and neurological diseases. Most large multinational companies are interested and engaged in the commercialization of herb-based formulations, and consumers continue to seek natural-based therapies. Herbs for Diabetes and Neurological Disease Management provides insight into plant-based novel molecules targeted for diabetes and neurological disorders. It looks at a selection of herbs that have proven effective in the management of diabetes and neurological disorders, including migraine, epilepsy, memory disorders, depression, and more. Divided into ten chapters focusing on diabetes and its macro- and microvascular complications (migraine, epilepsy, memory disorders, depression and other neuropsychiatric disorders), this book is structured to provide a source of reliable information and enrich the knowledge of readers. Each chapter briefly explains the epidemiology and pathophysiology of the disease state and the possible role of herbal drugs in the prevention of the particular disease. The reported pharmacological activities and possible mechanism of action of herbal drugs are also discussed in detail, which makes this book informative and unique. This new volume will be a reliable reference complementing the substantial information on the use of herbal drugs in diabetes and neurological disorders that serve as the pillars of drug discovery and development.

Progress in Medicinal Chemistry

Progress in Medicinal Chemistry Book
Author : Anonim
Publisher : Elsevier
Release : 2019-06-17
ISBN : 0444642773
Language : En, Es, Fr & De

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Book Description :

Progress in Medicinal Chemistry, Volume 58 provides a review of eclectic developments in medicinal chemistry, with each chapter written by an international board of authors. Topics covered in this new release include Amyotrophic lateral sclerosis (ALS), Covalent-binding Drugs, Natural Product Drug Delivery - A Special Challenge?, and SMN2 gene splicing modifier, and more. Provides extended, timely reviews of topics in medicinal chemistry Contains targets and technologies relevant to the discovery of tomorrow's drugs Presents analyses of successful drug discovery programs

Progress in Medicinal Chemistry

Progress in Medicinal Chemistry Book
Author : Anonim
Publisher : Elsevier
Release : 2019-03-14
ISBN : 0444642781
Language : En, Es, Fr & De

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Book Description :

Progress in Medicinal Chemistry, Volume 58, provides a review of eclectic developments in medicinal chemistry, with each chapter written by an international board of authors. Topics covered in this new release include Amyotrophic lateral sclerosis (ALS), Covalent-binding Drugs, Natural Product Drug Delivery – A Special Challenge?, and SMN2 gene splicing modifier, and more. Provides extended, timely reviews of topics in medicinal chemistry Contains targets and technologies relevant to the discovery of tomorrow’s drugs Presents analyses of successful drug discovery programs

Standard Poor s Stock Reports

Standard   Poor s Stock Reports Book
Author : Anonim
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Standard Poor s Stock Reports book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Frontiers in Clinical Drug Research CNS and Neurological Disorders

Frontiers in Clinical Drug Research   CNS and Neurological Disorders Book
Author : Atta-ur- Rahman
Publisher : Bentham Science Publishers
Release : 2017-12-21
ISBN : 1681085852
Language : En, Es, Fr & De

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Book Description :

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. The fifth volume of this series features reviews that cover the following topics: -drug treatment for spinal cord injury -action tremors -natural products for Alzheimer’s disease treatment -non pharmacological approaches towards pain management -biosensors for detecting neurodegenerative diseases -NMDA receptor targeting -alkaloid antidepressants

Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards

Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Plunkett s Biotech Genetics Industry Almanac

Plunkett s Biotech   Genetics Industry Almanac Book
Author : Anonim
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The only complete guide to the technologies and companies in the biotech and genetics industry.