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Discovery And Development Of Antidiabetic Agents From Natural Products

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Discovery and Development of Antidiabetic Agents from Natural Products

Discovery and Development of Antidiabetic Agents from Natural Products Book
Author : Goutam Brahmachari
Publisher : Elsevier
Release : 2016-10-11
ISBN : 0128096926
Language : En, Es, Fr & De

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Book Description :

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

Discovery and Development of Anti Inflammatory Agents from Natural Products

Discovery and Development of Anti Inflammatory Agents from Natural Products Book
Author : Goutam Brahmachari
Publisher : Natural Product Drug Discovery
Release : 2019-09
ISBN : 9780128169926
Language : En, Es, Fr & De

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Book Description :

Discovery and Development of Anti-Inflammatory Agents from Natural Products, the latest volume in the Natural Product Drug Discovery series, presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations, with this volume focusing on molecules of natural origin and their synthetic analogues that have the potential to act against the pathogens responsible for inflammatory diseases. All aspects of each are covered, including isolations and structure elucidations, in vitro and in vivo biological activity, synthetic optimization, investigations of pharmacodynamics and kinetics, and the structure-activity relationships of anti-inflammatory natural products. Written by active researchers and leading experts, this book brings together an overview of current discoveries and trends in this field. It will be a valuable resource for researchers working to discover promising leads for the development of pharmaceuticals in the prevention and treatment of anti-inflammatory diseases. Features contributions from active researchers and leading experts working in medicinal natural products and herbal formulations Includes recent, cutting-edge advances on medicinal natural products, along with preventative therapies for different kinds of inflammation-directed diseases Offers an authoritative source of information on the industrial application of natural products for medicinal purposes

Discovery and Development of Neuroprotective Agents from Natural Products

Discovery and Development of Neuroprotective Agents from Natural Products Book
Author : Goutam Brahmachari
Publisher : Elsevier
Release : 2017-05-18
ISBN : 0128097698
Language : En, Es, Fr & De

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Book Description :

Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer’s disease, Parkinson’s disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs. Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab

Medicinal Plants of South Asia

Medicinal Plants of South Asia Book
Author : Muhammad Asif Hanif,Haq Nawaz,Muhammad Mumtaz Khan,Hugh J. Byrne
Publisher : Unknown
Release : 2019-09-17
ISBN : 9780081026595
Language : En, Es, Fr & De

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Book Description :

Medicinal Plants of South Asia: Novel Sources for Drug Discovery provides a comprehensive review of medicinal plants of this region, highlighting chemical components of high potential and applying the latest technology to reveal the underlying chemistry and active components of traditionally used medicinal plants. Drawing on the vast experience of its expert editors and authors, the book provides a contemporary guide source on these novel chemical structures, thus making it a useful resource for medicinal chemists, phytochemists, pharmaceutical scientists and everyone involved in the use, sales, discovery and development of drugs from natural sources. Provides comprehensive reviews of 50 medicinal plants and their key properties Examines the background and botany of each source before going on to discuss underlying phytochemistry and chemical compositions Links phytochemical properties with pharmacological activities Supports data with extensive laboratory studies of traditional medicines

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry Book
Author : Suresh R. Naik,Ganesh R. Kokil
Publisher : Elsevier Inc. Chapters
Release : 2013-03-15
ISBN : 0128084928
Language : En, Es, Fr & De

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Book Description :

Bioactive natural products are an excellent source of novel therapeutics. The search for bioactive molecules from nature continues to play a major role in developing new generation natural products of therapeutic importance. The present critical review includes research work carried out by active researchers in natural products’ chemistry, pharmacology and therapeutics, and their implications in antidiabetic medications. This compiled scientific information will be a useful resource for future research especially in indentifying promising leads and direction for the development of novel drugs including useful adjuvants for the treatment of diabetic patient. The present therapeutic approaches in the treatment of diabetes are mainly focused to lower the elevated blood glucose by reducing its absorption in gastrointestinal tract, enhancing the sensitivity of insulin, controlling or modulating hepatic glucose output, and increased utilization of the glucose by the peripheral tissues. Involvement of oxidative stress and its impact on the cellular damage in diabetes mellitus has been established and could be a useful paradigm for the development of novel antihyperglycemics along with other therapeutic strategies. The present review also highlights the effects of various herbs, phytoconstituents, phytochemicals, microbial metabolites, and products of marine origins on hyperglycemic/diabetic conditions. Furthermore, efforts were made to discuss novel molecular targets such as insulin-signaling pathways, peroxisome proliferative activating receptor-γ, and G-protein-coupled receptors that are participating in enhancing/influencing insulin secretion, critical carbohydrate metabolism pathways, endoplasmic reticulum stress-related pathways, intracellular events associated intracellular inflammation, and chromatin-modification pathways involvement in antidiabetic activity and their significance.

Natural Products in Medicinal Chemistry

Natural Products in Medicinal Chemistry Book
Author : Stephen Hanessian
Publisher : John Wiley & Sons
Release : 2013-12-18
ISBN : 3527676562
Language : En, Es, Fr & De

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Book Description :

The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer

Chemistry and Bioactivity of Boswellic Acids and Other Terpenoids of the Genus Boswellia

Chemistry and Bioactivity of Boswellic Acids and Other Terpenoids of the Genus Boswellia Book
Author : Ahmed Al-Harrasi,Hidayat Hussain,René Csuk,Husain Yar Khan
Publisher : Elsevier
Release : 2018-09-15
ISBN : 9780081024416
Language : En, Es, Fr & De

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Book Description :

Exhibiting a wealth of interesting activities and novel structures, Boswellic acid and the other terpenoids of the genus Boswellia (from which frankincense is derived) are a growing source of interest for the natural product drug discovery community. Chemistry and Bioactivity of Boswellic Acids and Other Terpenoids of the Genus Boswellia presents, in a single volume for the first time, key research into their structures, synthesis and potential as starting points for the development of medicinal agents. Drawing on the authors' expert knowledge, this volume is an interesting insight into the identification of novel compounds from endemic plant sources, and is a useful tool for all researchers involved in the discovery and development of bioactive structures from natural products. Collates key information on the underlying chemistry and activities of bioactive agents from the Boswellia species Highlights techniques applicable to the study of natural products across the globe Provides insights into the assessment of medicinal natural products with high economic potential

Medicinal Foods As Potential Therapies for Type 2 Diabetes and Associated Diseases

Medicinal Foods As Potential Therapies for Type 2 Diabetes and Associated Diseases Book
Author : Solomon Habtemariam
Publisher : Academic Press
Release : 2019-06-25
ISBN : 9780081029220
Language : En, Es, Fr & De

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Book Description :

Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases: The Chemical and Pharmacological Basis of their Action focuses on active pharmacological principles that modulate diabetes, associated risk factors, complications and the mechanism of action of widely used anti-diabetic herbal plants-rather than just the nutritional composition of certain foods. The book provides up-to-date information on acclaimed antidiabetic super fruits, spices and other food ingredients. Sections cover diabetes and obesity at the global level, the physiological control of carbohydrate and lipid metabolism, the pathophysiology of type-2 diabetes, the chemistry and pharmacology of a variety of spices, and much more. This book will be invaluable for research scientists and students in the medical and pharmaceutical sciences, medicinal chemistry, herbal medicine, drug discovery/development, nutrition science, and for herbal practitioners and those from the nutraceutical and pharm industries. Provides background knowledge on type-2 diabetes and its pathophysiology and therapeutic targets down to the molecular level Explores, in detail, the chemistry or secondary metabolites of the indicated foods that potentially modify diabetes and/or associated diseases Examines the pharmacological findings on medicinal foods, including available clinical trials

Search

Search Book
Author : Anonim
Publisher : Unknown
Release : 1974
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Search book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug Discovery Handbook

Drug Discovery Handbook Book
Author : Shayne C. Gad
Publisher : Wiley-Interscience
Release : 2005-07-11
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

THE FIRST COMPREHENSIVE GUIDE TO THE METHODS AND TECHNIQUES OF DRUG DISCOVERY The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs. This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systems biology Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more Specific approaches to drug discovery, including problems that are encountered, solutions to these problems, and limitations of various methods and techniques The thorough coverage and practical, scientifically valid problem-solving approach of Drug Discovery Handbook will serve as an invaluable aid in the complex task of developing new drugs.

The Journal of Environment Development

The Journal of Environment   Development Book
Author : Anonim
Publisher : Unknown
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Journal of Environment Development book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Diabetes Mellitus Epidemic Combat the Challenge

Diabetes Mellitus Epidemic  Combat the Challenge Book
Author : Asian Network of Research on Antidiabetic Plants. International Seminar,Biswapati Mukherjee,Pratip Kumar Debnath,Tuhin Kanti Biswas,Asian Network of Research on Antidiabetic Plants,Shrabana Chakrabarti,Shivaji Banerjee
Publisher : TATA McGraw-Hill Publishing Company
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Contributed articles presented at the fourth International Seminar of Asian Network of Research on Antidiabetic Plants.

Classic Botanical Reprints 227 238

Classic Botanical Reprints   227 238 Book
Author : Anonim
Publisher : Unknown
Release : 199?
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Classic Botanical Reprints 227 238 book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Index of Conference Proceedings Received

Index of Conference Proceedings Received Book
Author : British Library. Document Supply Centre
Publisher : Unknown
Release : 1986
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Index of Conference Proceedings Received book written by British Library. Document Supply Centre, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Journal of the Chemical Society of Pakistan

Journal of the Chemical Society of Pakistan Book
Author : Chemical Society of Pakistan
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Journal of the Chemical Society of Pakistan book written by Chemical Society of Pakistan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Natural Products

Natural Products Book
Author : Nancy Mulford,Carol Sussman
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Natural Products book written by Nancy Mulford,Carol Sussman, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Two Centuries of American Medicine 1776 1976

Two Centuries of American Medicine  1776 1976 Book
Author : James Bordley,Abner McGehee Harvey
Publisher : W B Saunders Company
Release : 1976
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Chronicles advances in medical education and the prevention and treatment of disease in the two hundred years since America's independence

Chemistry of the Amazon

Chemistry of the Amazon Book
Author : Peter Rudolf Seidl,Otto Richard Gottlieb
Publisher : Amer Chemical Society
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Agroforest strategies for alleviating soil chemical constraints to food and fiber production in the Brazilian Amazon.

The African and Arabian Moringa Species

The African and Arabian Moringa Species Book
Author : Solomon Habtemariam
Publisher : Elsevier
Release : 2017-06-09
ISBN : 0081022948
Language : En, Es, Fr & De

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Book Description :

The African and Arabian Moringa Species: Chemistry, Bioactivity and Therapeutic Applications reviews the botany, socioeconomic significance and underlying chemistry of these interesting plants. The book begins by addressing the botanical and socioeconomic aspect of M. stenopetala, one of the most widely cultivated species within the genus. Next, it reviews the chemistry of the plant, with a systematic presentation covering the seed oil, various secondary metabolites, and issues relating to quality control. Final sections address the chemistry behind the reported use of the plant for the management of various diseases, highlighting potential antioxidant, antimicrobial, antidiabetic, anticancer properties and more. Other African and Arabian Moringa species, from their botany, to their chemical and pharmacological profiles are also included. Drawing on the author’s latest research and the most current literature in the field, this book is an invaluable guide for researchers in medicinal chemistry, herbal medicine, drug discovery/development, and plant derived natural products within both industry and academic environments. Outlines the botanical description, traditional uses and socioeconomic significance of the African and Arabian Moringa plants Exhaustively discusses the chemistry of these plants to highlight secondary metabolites and methodologies for their isolation, identification and quality control Discusses the future potential of the plants and their chemical components for various disease conditions

Pharmacology

Pharmacology Book
Author : Ruth R. Levine
Publisher : Unknown
Release : 1978
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Pharmacology book written by Ruth R. Levine, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.