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Discovery And Development Of Anti Breast Cancer Agents From Natural Products

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Discovery and Development of Anti Breast Cancer Agents from Natural Products

Discovery and Development of Anti Breast Cancer Agents from Natural Products Book
Author : Goutam Brahmachari
Publisher : Elsevier
Release : 2021-06-24
ISBN : 0128212780
Language : En, Es, Fr & De

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Book Description :

Discovery and Development of Anti-Breast Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations. This volume in the Natural Products Drug Discovery series focuses on molecules of natural origin and their synthetic analogs that show promising potential to act as anti-breast cancer and chemotherapeutic agents. Combining foundational background information on cancer mechanisms with details of medicinal structures from natural products, this volume compiles the latest developments from across interdisciplinary fields. Discovery and Development of Anti-Breast Cancer Agents from Natural Products will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for breast cancer, highlighting a number of key structures from natural products and exploring possible future developments in the area. Highlights active agents from natural sources for development as novel anti-cancer agents Features contributions from active researchers and leading experts working in the field Includes foundational background information on both breast cancer mechanisms and natural product structures to support researchers from different disciplines

Anticancer Agents from Natural Products

Anticancer Agents from Natural Products Book
Author : Gordon M. Cragg,David G. I. Kingston,David J. Newman
Publisher : CRC Press
Release : 2005-06-13
ISBN : 1420039652
Language : En, Es, Fr & De

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Book Description :

Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen

Discovery and Development of Antidiabetic Agents from Natural Products

Discovery and Development of Antidiabetic Agents from Natural Products Book
Author : Goutam Brahmachari
Publisher : Elsevier
Release : 2016-10-11
ISBN : 0128096926
Language : En, Es, Fr & De

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Book Description :

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

New Approaches to Natural Anticancer Drugs

New Approaches to Natural Anticancer Drugs Book
Author : Soodabeh Saeidnia
Publisher : Springer
Release : 2015-02-05
ISBN : 3319140272
Language : En, Es, Fr & De

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Book Description :

This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also includes discussion of new areas such as biotechnology and nanoparticles. Chapters explain the challenges and developments in anti-cancer drug discovery approaches, traditional remedies for prevention and treatment of cancer, marine-derived anti-cancer compounds, and antibiotics used as anti-cancer agents, as well as different classes of terpenoids and carbohydrates, which have been the subject of discussion in this field as efficient anti-cancer candidates. This book will be a concise guide for researchers in the field of pharmaceutical sciences, students and residents in pharmacy and medicine as well as those researching phytochemistry and natural products.

Anticancer Drug Development

Anticancer Drug Development Book
Author : Bruce C. Baguley,David J. Kerr
Publisher : Elsevier
Release : 2001-11-17
ISBN : 0080490441
Language : En, Es, Fr & De

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Book Description :

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects of anticancer drug development Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques Hundreds of references that allow the reader to access relevant scientific and medical literature Clear illustrations, some in color, that provide both understanding of the field and material for teaching

Using Old Solutions to New Problems

Using Old Solutions to New Problems Book
Author : Marianna Kulka
Publisher : BoD – Books on Demand
Release : 2013-06-19
ISBN : 9535111582
Language : En, Es, Fr & De

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Book Description :

The medicinal use of plants, animals and microorganisms has been a part of human evolution and likely began before recorded history. Is it possible that this knowledge can be used to create powerful new drugs and solve some of the human health problems facing us today? This book is a collection of an expert team of agronomists, chemists, biologists and policy makers who discuss some of the processes involved in developing a naturally-sourced bioactive compound into a drug therapy. These experts define a natural compound and elucidate the processes required to find, extract and define a naturally-derived bioactive molecule. Finally, they describe the necessity for understanding the fundamental mechanisms of disease before applying bioactive molecules in bioassay-guided drug discovery platforms.

Bioactive Natural Products for the Management of Cancer from Bench to Bedside

Bioactive Natural Products for the Management of Cancer  from Bench to Bedside Book
Author : Anil K. Sharma
Publisher : Springer
Release : 2019-07-17
ISBN : 9811376077
Language : En, Es, Fr & De

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Book Description :

This book illustrates the importance of the Natural Biometabolites, which offer a rich reservoir of candidate compounds for drug discovery in the battle against cancer. Recent research and development efforts concerning anti-cancer drugs derived from natural products have led to the identification of numerous candidate molecules that inhibit cancer cell proliferation and metastasis using a variety of mechanisms. Given its scope, the book offers a valuable resource for cancer biologists and general oncologists alike, while also benefitting research professionals in Science, Nursing, Medicine, Biochemistry, Genetics and Bioscience who wish to understand the fundamentals of prognosis and prediction in tumorigenesis. Moreover, the book provides an essential platform for understanding drug resistance mechanisms and combatting the growing menace of multidrug resistance.

Drug Discovery and Development

Drug Discovery and Development Book
Author : Ramarao Poduri
Publisher : Springer Nature
Release : 2021-02-15
ISBN : 9811555346
Language : En, Es, Fr & De

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Book Description :

This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.

Anti Angiogenesis Drug Discovery and Development

Anti Angiogenesis Drug Discovery and Development Book
Author : M. Iqbal Choudhary
Publisher : Bentham Science Publishers
Release : 2014-10-29
ISBN : 1608058662
Language : En, Es, Fr & De

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Book Description :

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Anti-angiogenesis Drug Discovery and Development provides is an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two recent decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians. The second volume of this ebook series covers topics including: -Clear Cell Renal Cell Carcinoma as a Model of Pathological Angiogenesis -Discovery and Development of Antiangiogenetic Drugs in Ovarian Cancer -Anti-Angiogenic Therapy and Cardiovascular Diseases … and more.

Natural Products for Cancer Prevention and Therapy

Natural Products for Cancer Prevention and Therapy Book
Author : Anupam Bishayee,Mukerrem Betul Yerer-Aycan
Publisher : MDPI
Release : 2018-11-07
ISBN : 3038973106
Language : En, Es, Fr & De

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Book Description :

This book is a printed edition of the Special Issue "Natural Products for Cancer Prevention and Therapy" that was published in Nutrients

Life Saving Drugs

Life Saving Drugs Book
Author : John Mann
Publisher : Royal Society of Chemistry
Release : 2007-10-31
ISBN : 184755122X
Language : En, Es, Fr & De

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Book Description :

In 1900 only a handful of drugs (morphine, quinine, aspirin, etc) had genuine efficacy but had little value for bacterial or viral infections or cancer. These conditions were usually untreatable. Now there are literally thousands of drugs which offer cures or greatly extended life-spans for those with life-threatening conditions. Life Saving Drugs: the Elusive Magic Bullet describes the discovery and development of antibacterial, anti-viral and anti-cancer drugs. The book highlights the colourful characters behind the inventions and the huge improvements in quality of life and life-expectancy that these drugs have produced. Emphasis is given to the new drugs that have emerged as a result of knowledge of the human genome, and the ways in which the newer drugs are being designed to tackle disease, particularly cancer, at the genetic level. Chemical structures are provided for all of the key drugs and the book is well illustrated. Life Saving Drugs: the Elusive Magic Bullet can be read as a history of drug development during the past 100 years by those with only a passing knowledge of chemistry. For anyone entering the medical profession, pharmacy, or nursing, it will provide a superb basic knowledge of all drugs they are ever likely to meet, including their modes of action. For the chemist or medicinal chemist, it will provide the fundamental knowledge of life-saving drugs that they all should know. And for the non-scientist who wants to know about 'super-bugs', SARS, Ebola, and all of the wonderful advances in treating cancer, it is illuminating and easy to read.

Drug Discovery and Development

Drug Discovery and Development Book
Author : Omboon Vallisuta,Suleiman Olimat
Publisher : BoD – Books on Demand
Release : 2015-06-03
ISBN : 9535121286
Language : En, Es, Fr & De

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Book Description :

It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.

Drug Discovery from Natural Products

Drug Discovery from Natural Products Book
Author : Olga Genilloud,Francisca Vicente,David E. Thurston,Ana Martinez,David Rotella,Salvatore Guccione,Robin Ganellin
Publisher : Royal Society of Chemistry
Release : 2012
ISBN : 1849733619
Language : En, Es, Fr & De

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Book Description :

An integrated review of the most recent trends in natural products drug discovery and key lead candidates that are outstanding for their chemistry and biology in novel drug development.

Unique Aspects of Anti cancer Drug Development

Unique Aspects of Anti cancer Drug Development Book
Author : Jolanta Natalia Latosińska,Magdalena Latosińska
Publisher : BoD – Books on Demand
Release : 2017-07-12
ISBN : 9535133470
Language : En, Es, Fr & De

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Book Description :

The evidence of cancer in humans, animals and plant species suggests that it is as old as multicellular life on Earth. Why is it so difficult to understand and fight? Because cancer begins from the organism's own mutated single cell focused on its own survival. It would be naive to expect that cancer could be ever entirely eliminated, but there is still hope for finding effective treatments. The book is to give a view of selected aspects of cancer like its spread in nature, novel anticancer drugs based on Chinese herbs or birch bark, novel promising targets of annexins and kinases and progress in immunotherapy. It is our hope that you will find in this book interesting, inspiring and stimulating information concerning cancer research.

Medicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs Book
Author : Carmen Avendano,J. Carlos Menendez
Publisher : Elsevier
Release : 2015-06-11
ISBN : 0444626670
Language : En, Es, Fr & De

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Book Description :

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Drug Development for Cancer and Diabetes

Drug Development for Cancer and Diabetes Book
Author : K. Saravanan,Chukwuebuka Egbuna,Horne Iona Averal,S. Kannan,S. Elavarasi,Bir Bahadur
Publisher : CRC Press
Release : 2020-08-30
ISBN : 1000639983
Language : En, Es, Fr & De

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Book Description :

Key features include: Details the role of plants for the treatment and management of cancer and diabetes Discusses the role of phytocompounds as ligands for cancer and diabetic targets Reviews plants and the potential of phytochemicals as antidiabetic and anticancer drugs Explores the green biosynthesis of nanoparticles and their treatment efficiency

The Role of Natural Products in Drug Discovery

The Role of Natural Products in Drug Discovery Book
Author : J. Mulzer,R. Bohlmann
Publisher : Springer Science & Business Media
Release : 2013-04-17
ISBN : 3662040425
Language : En, Es, Fr & De

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Book Description :

Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.

Anticancer Agents

Anticancer Agents Book
Author : Qiao-Hong Chen
Publisher : MDPI
Release : 2021-03-02
ISBN : 3036501401
Language : En, Es, Fr & De

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Book Description :

This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.

Phenotypic Drug Discovery

Phenotypic Drug Discovery Book
Author : Angelique Augustin,Beverley Isherwood
Publisher : Royal Society of Chemistry
Release : 2020-12-10
ISBN : 1788018761
Language : En, Es, Fr & De

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Book Description :

Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and academia, this publication will equip researchers with a thought-provoking guide to the application and future development of contemporary phenotypic drug discovery for clinical success.

Naturally Occurring Small Molecules For Disease And Cancer Treatment Therapeutic Benefits In Combination Therapy

Naturally Occurring Small Molecules For Disease And Cancer Treatment  Therapeutic Benefits In Combination Therapy Book
Author : Ho John Wing Shing
Publisher : World Scientific
Release : 2019-04-23
ISBN : 9814525642
Language : En, Es, Fr & De

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Book Description :

Western drugs and target medicines for disease treatment come with undesirable side effects that have limited their use in patients for an extended period of time. It is warranted to develop a treatment strategy with alternative medicines to reduce toxicity relating to drugs, in particular, cancer drugs. Thus, a combination therapy with herbal medicines provides a more effective treatment method for hard-to-treat diseases. The recent breakthroughs in naturally occurring small molecules from herbal medicines have provided experimental evidence and are clinically significant in treatment strategies.This unique volume presents the recent developments in the field of herbal medicines for the treatment of diseases and cancer. Recent progress on small molecules isolated from herbal medicines that exhibit therapeutic benefits in humans is highlighted. The book provides an overview of the significant discoveries and pioneering contributions of herbal medicines in combination with other drugs; the author's evaluation of the combination therapy in cancer treatment; and a recent discovery of crocodile tissue extract with pharmacological properties.