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Direct Nose To Brain Drug Delivery

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Direct Nose to Brain Drug Delivery

Direct Nose to Brain Drug Delivery Book
Author : Chandrakantsing Pardeshi,Eliana B. Souto
Publisher : Academic Press
Release : 2021-06-15
ISBN : 9780128225226
Language : En, Es, Fr & De

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Book Description :

Direct Nose to Brain Drug Delivery: Mechanism, Technological Advances, Applications and Regulatory Updates provides the reader with precise knowledge about the strategies and approaches for enhanced nose to brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration, includes an overview on the toxicity aspects of the various materials used to develop the direct nose to brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. Direct Nose to Brain Drug Delivery: Mechanism, Technological Advances, Applications and Regulatory Updates is a crucial source that will assist the veteran scientists, industrial technologists, and clinical research professionals to develop new drug delivery systems, and novel drug administration devices for the treatment of neuro-ailments. Explains the targeting approaches for enhanced brain targeting following intranasal drug administration Explores the various nanocarriers developed to date for neurotherapeutic delivery via nose to brain Discusses pharmaceutical and biomedical applications after nose to brain delivery of therapeutic pharmaceuticals and biologicals

The Development and Application of Biological Models for Evaluation of Direct Nose to brain Drug Delivery Systems

The Development and Application of Biological Models for Evaluation of Direct Nose to brain Drug Delivery Systems Book
Author : Alpesh Mistry
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The olfactory neuroepithelium is the only part of the central nervous system that is exposed directly to the external environment. Therefore, it is the only non-invasive drug delivery route to the brain. Surface modification of PS nanoparticles with chitosan (C-PS), polysorbate 80 (P80-PS) and polysorbate 80+FCS (P80-FCS-PS) changed the toxicity and distribution of these nanoparticles in olfactory mucosae. In addition, a reduction in nanoparticle diameter from 200nm to 20nm increased nanoparticle mucosal penetration and possibly also their cellular toxicity. In vitro vertical Franz diffusion chamber and in vivo mouse models were adapted to investigate the transport of nanoparticles via the olfactory system. For the in vitro model, preliminary studies found that olfactory epithelium lined the caudal portion of the dorsal nasal turbinate in the porcine nasal cavity. To ensure the scientific validity of the diffusion chamber studies, it was necessary to prove that the experimental procedures themselves (without the addition of nanoparticles) had no effect on the mounted tissue. Therefore, viability and cellular morphology of the dissected olfactory epithelia were assessed prior to application of nanoparticles to tissues. Alamar BlueTM viability and histological findings showed that the diffusion chamber experiment did not affect the olfactory tissue when compared to samples that were not mounted on the apparatus. Citrate buffer (pH6.0) had significantly reduced the viability (PD, Isc and Alamar BlueTM) of the porcine olfactory epithelium compared to SNS buffer (pH7.4) but it did not kill it. Citrate buffer may have depleted the mucosal pH gradient in the epithelium. Overall both SNS buffered and citrate buffered porcine olfactory epithelia were suitable for nanoparticle transport studies in the vertical Franz diffusion cell. The in vitro and in vivo biological models showed surface modification had changed the distribution of nanoparticles within the epithelia. There was good agreement between particle losses from donor chamber, fluorescence microscopy images and stereology results that C-PS particles adhered to extracellular mucus to a greater extent compared to PS and P80-FCS-PS. P80-PS nanoparticles were taken into the nasal epithelial cells to a greater extent than C-PS. Nanoparticles were not transported to the receiver chamber in vitro or the olfactory bulbs in vivo. The size of the nanoparticles was also important. Fluorescence microscopy and stereology showed that greater numbers of 100nm PS and 100nm P80-FCS-PS were taken up into mouse olfactory epithelial cells compared to 200nm diameter equivalents. Larger particles may not have penetrated mucus as effectively as smaller ones. Bright field microscopy images of olfactory epithelia dismounted from the diffusion chamber apparatus after transport study with C-PS nanoparticles showed that these particles caused the greatest amount of cellular damage compared to PS, P80-PS and P80-FCS-PS systems. Greater damage was observed for progressively smaller particles. For example, 20nm C-PS may have accessed subcellular organelles such as mitochondria to cause cell death by oxidative stress. However, similar findings in the mouse model were not observed. It was hypothesised that, unlike the in vitro model, the mouse model may have been able to maintain a pH gradient across the mucous layer by neutralising the acidity from the citrate buffer using blood borne HCO3− ions. This would protect the epithelial cells by causing C-PS to aggregate in the mucus thereby preventing them from accessing the epithelial cells.

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents Book
Author : Manju Rawat Singh,Deependra Singh,Nagendra Singh Chauhan,Jagat Kanwar
Publisher : Academic Press
Release : 2020-03
ISBN : 0128196661
Language : En, Es, Fr & De

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Book Description :

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents provides sound data on the utility of biological and plant-based drugs and describes challenges faced in all aspects offering indispensable strategies to use in the development of bioactive medicines. Bioactive based medications are commonly used throughout the world and have been recognized by physicians and patients for their therapeutic efficacy. Bioactive formulations, including their subordinates and analogs, address 50% of all medicines in clinical practice. Novel bioactive medicine transporters can cure many disorders by both spatial and transitory approaches and have various justifications in medicinal potential. This book presents information on the utility of natural, plant, animal and bioengineered bioactive materials. It is a fundamental source of information and data for pharmacognosists, pharmaceutical analysts, drug transport scientists and pharmacologists working in bioactive medications.

Brain Targeted Drug Delivery Systems

Brain Targeted Drug Delivery Systems Book
Author : Huile Gao,Xiaoling Gao
Publisher : Academic Press
Release : 2018-09-20
ISBN : 012814002X
Language : En, Es, Fr & De

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Book Description :

Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life, this book highlights advances and new research in drug delivery methods to the brain. Provides an overview of brain targeting drug delivery that is useful to both academic and industry-based researchers Discusses key points in developing brain targeting drug delivery systems Summarizes and presents currently available strategies for brain targeting drug delivery Covers not only current studies and their strengths, but also gives insight into the pitfalls of current research

Drug Delivery Systems

Drug Delivery Systems Book
Author : Anonim
Publisher : Academic Press
Release : 2019-10-23
ISBN : 0128145080
Language : En, Es, Fr & De

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Book Description :

Drug Delivery Systems examines the current state of the field within pharmaceutical science and concisely explains the history of drug delivery systems, including key developments. The book translates the physicochemical properties of drugs into drug delivery systems administered via various routes, such as oral, parenteral, transdermal and inhalational. Regulatory and product development topics are also explored. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of drug delivery systems within the pharmaceutical sciences industry and research, as well as in chemical engineering. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists. This book provides a comprehensive examination that is suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnologies, and related industries. Provides up-to-date information on how to translate the physicochemical properties of drugs into drug delivery systems Explores how drugs are administered via various routes, such as oral, parenteral, transdermal and inhalational Contains extensive references and further reading for course and self-study

Drug Delivery Devices and Therapeutic Systems

Drug Delivery Devices and Therapeutic Systems Book
Author : Eric Chappel
Publisher : Academic Press
Release : 2020-11-07
ISBN : 0128198397
Language : En, Es, Fr & De

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Book Description :

Drug Delivery Devices and Therapeutic Systems examines the current technology and innovations moving drug delivery systems (DDS) forward. The book provides an overview on the therapeutic use of drug delivery devices, including design, applications, and a description of the design of each device. While other books focus on the therapy, the primary emphasis in this book is on current technologies for DDS applications, including microfluidics, nanotechnology, biodegradable hydrogel and microneedles, with a special emphasis on wearable DDS. As part of the Developments in Biomedical Engineering and Bioelectronics series, this book is written by experts in the field and informed with information directly from manufacturers. Pharmaceutical scientists, medical researchers, biomedical engineers and clinical professionals will find this an essential reference. Provides essential information on the most recent drug delivery systems available Explains current technology and its applications to drug delivery Contains contributions from biomedical engineers, pharmaceutical scientists and manufacturers

Gibaldi s Drug Delivery Systems in Pharmaceutical Care

Gibaldi s Drug Delivery Systems in Pharmaceutical Care Book
Author : Mary Lee,Archana Desai
Publisher : ASHP
Release : 2007
ISBN : 1585281360
Language : En, Es, Fr & De

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Book Description :

It is important to make therapeutics a critical component of teaching about dosage forms and to make dosage forms and drug delivery systems an integral part of therapeutics. This book will be the first to focus on the therapeutic impact of drug dosage forms.Tying together concepts of traditional pharmaceutics with therapeutics, Drug Delivery Systemsin Pharmaceutical Care demonstrates how the modern clinical pharmacist can integrate knowledge in pharmaceutical sciences and therapeutics with appreciation of patient needs and nuances to advise on preferable and optimal product choices.Each chapter represents a collaboration of a clinical pharmacist practitioner and a pharmaceutical scientist. This unique perspective takes the science of dosage form design and helps translate the theory into the pragmatic.Special Features: Case studies and problems to help students get a better understanding of concepts Well-organized chapters with outlines and objectives Summary tables and helpful figures, along with reasonable compilations of original references Final sections with 'Learning Points' that reinforce essential material. Foreword by William J. Jusko, PhD, Professor and Chair, University of Buffalo, Department of Pharmaceutical Sciences

Blood Brain Barrier

Blood Brain Barrier Book
Author : David Kobiler,Shlomo Lustig,Shlomo Shapira
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461505798
Language : En, Es, Fr & De

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Book Description :

The vasculature of the central nervous system (eNS) is characterized by the existence of the blood-brain barrier (BBB), which can be regarded as both an anatomical and physiological phenomenon. The BBB is formed by a complex cellular system of endothelial cells, astroglia, pericytes, perivascular macrophages and a basal membrane, although the anatomic substrate of the BBB is the interendothelial tight junctions that form a continuous sealing. The BBB serves as an exquisitely controlled, functional gate to the eNS. It not only protects the brain from agents in the blood that could impair neurological function, but also controls the influx and efflux of numerous substances to maintain proper homeostasis and provide the brain with necessary nutrients. The structural and functional integrity of the BBB was shown to be dramatically altered during various diseases of the eNS, including neoplasia, ischemia, trauma, hypertension, inflammation and epilepsy. Recent years research has partially elucidated the mechanisms underlying the development of some of these brain disorders as well as the pathways used by different pathogens, like bacteria and viruses, to initiate eNS infections. The development of in vitro models of the BBB had instrumental role in the understanding of the involvement of the BBB in the pathogenesis of several eNS diseases. The intimate, functional association between the function of the brain and the activity of the BBB makes the later a target for pharmacological modulation that will expand the therapeutic possibilities for a range of neurological diseases.

Drug Tranport ers and the Diseased Brain

Drug Tranport ers  and the Diseased Brain Book
Author : Fundación Dr. Antonio Esteve. Symposium,Albertus G. De Boer
Publisher : Elsevier Science Health Science Division
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

There are many potent drugs available for many diseases of the brain (e.g. Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, Stroke, Brain tumors) The effectiviness however is not optimal since barriers in the brain prevent the drugs from reaching the brain in sufficient therapeutic concentrations (e.g. the blood-brain barrier and the blood-cerebrospinal fluid barrier). Drug Transport(ers) and the Diseased Brain contains the papers of a timely symposium held in Spain between 6 and 9 October 2004, which sets out not only the point of view of the academic researcher and the clinician, but also from the pharmaceutical industrial on how to overcome these barriers and how to treat brain diseases effectively. Blood-brain barrier and blood-cerebrospinal fluid-barrier drug transport; Drug targeting to the brain; Drug transporters at barriers in the brain

Journal of Nanoscience and Nanotechnology

Journal of Nanoscience and Nanotechnology Book
Author : Anonim
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Journal of Nanoscience and Nanotechnology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Applied and Environmental Microbiology

Applied and Environmental Microbiology Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Applied and Environmental Microbiology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Numerical Simulation and Experimental Testing to Improve Olfactory Drug Delivery with Electric Field Guidance of Charged Particles

Numerical Simulation and Experimental Testing to Improve Olfactory Drug Delivery with Electric Field Guidance of Charged Particles Book
Author : Jinxiang Xi
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Even though the direct nose-to-brain drug delivery has many clinical benefits, there are limited successes in delivering medication aerosols to the olfactory mucosa with standard inhalation devices. In this study, different delivery techniques were assessed in terms of their capacities to deliver drug aerosols to the olfactory epithelium. Specifically, the feasibility of electric field guidance of charged aerosols to the olfactory mucosa was evaluated in an image-based nose model both numerically and experimentally. Multi-sectional nasal cast replicas were fabricated using a 3-D printer to measure the olfactory deposition rates and visualize the deposition distributions. An intranasal deposition test platform was developed that comprised an electric field guidance system, a dry powder charging device, and a point-release nozzle. Numerical simulations were conducted using both ANSYS Fluent and COMSOL. We demonstrated that it is feasible to control charged particles inside the human nose use an external electric field. Both the point-release technique and electric field guidance of drug particles are essential in attaining optimal olfactory doses. Consistent deposition patterns were achieved between in vitro experiments and computational simulations. Future investigations are warrnated for further improvements of olfactory delivery through refining the particle generation, charging, and releasing, and navigation systems.

Acta P3 diatrica

Acta P3  diatrica Book
Author : Anonim
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Dissertation Abstracts International

Dissertation Abstracts International Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Dissertation Abstracts International book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Journal of Pharmacy and Pharmacology

Journal of Pharmacy and Pharmacology Book
Author : Anonim
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Enforcing Non proliferation

Enforcing Non proliferation Book
Author : Jean Pascal Zanders,Kathryn Nixdorff
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Focuses on international efforts to prevent biological agents and toxins being developed and used as weapons. The analysis is framed around the BTWC (Biological and Toxin Weapons Convention) and its associated Review Conferences."--Page 7.

Indian Science Abstracts

Indian Science Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 1991-10
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Indian Science Abstracts book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Encyclopedia of Physical Science and Technology

Encyclopedia of Physical Science and Technology Book
Author : Robert Allen Meyers
Publisher : Unknown
Release : 2002
ISBN : 9780122274213
Language : En, Es, Fr & De

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Book Description :

Following in the footsteps of the earlier editions, hundreds of the most respected scientists and engineers participated in the creation of this new edition, including many Nobel Laureates. The articles are in-depth, yet accessible, and address all of the key areas of physical science--including aeronautics, astronomy, chemistry, communications, computers, earth sciences, electronics, engineering, materials science, mathematics, nuclear technology, physics, power systems, propulsion, and space technology. (Midwest).

Pediatric Neurosurgery

Pediatric Neurosurgery Book
Author : William R. Cheek
Publisher : W B Saunders Company
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

-- The finest and most comprehensive coverage to be found anywhere. -- Totally reorganized into more logical sections. -- 40 new authors and 20 new chapters provide an up-to-date approach. -- A two-color design which highlights illustrations and important aspects of the text. -- Also provides references for additional information.