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Diagnostic And Therapeutic Applications Of Exosomes In Cancer

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Diagnostic and Therapeutic Applications of Exosomes in Cancer

Diagnostic and Therapeutic Applications of Exosomes in Cancer Book
Author : Mansoor M. Amiji,Rajagopal Ramesh
Publisher : Academic Press
Release : 2018-05-09
ISBN : 0128128046
Language : En, Es, Fr & De

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Book Description :

Diagnostic and Therapeutic Applications of Exosomes in Cancer evaluates the potential of exosome content manipulation in the development of novel therapeutics. In recent years, exosomes, the small vesicles produced by all cell types, have been identified as contributors to cancer growth and metastasis. However, due to their unique biophysical properties, they are also being tested for use in therapeutic design and delivery, as well as in diagnostics. This book presents a comprehensive analysis on exosomes, with a main emphasis on their biogenesis and signaling, use as biomarkers, and as tools for imaging, drug delivery and the treatment of cancer. Covers emerging pharmaceutical and diagnostic applications, including exosomes being tested as carriers of anticancer drugs, ongoing clinical trials, and exosomes as imaging agents for cancer diagnosis and treatment Brings together a team of highly regarded international authors who provide a full-rounded analysis Presents comprehensive coverage of the unique biophysical properties of exosomes Explores current and future possibilities

Nanotechnology in Cancer Management

Nanotechnology in Cancer Management Book
Author : Kamil Reza Khondakar,Ajeet Kumar Kaushik
Publisher : Elsevier
Release : 2021-05-18
ISBN : 0128181559
Language : En, Es, Fr & De

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Book Description :

Nanotechnology in Cancer Management: Precise Diagnostics toward Personalized Health Care provides a well-focused and comprehensive overview of technologies involved in early stage cancer diagnostics via the detection of various cancer biomarkers, both in-vitro and in-vivo. The book briefly describes the advancement in cancer biomarker research relating to cancer diagnostics, covering fundamental aspects of various techniques, especially transduction methodologies, such as electrochemical, optical, magnetic, etc. In addition, it describes approaches on how to make options cost-effective, scalable for clinical application, and user-friendly. Advancements in technology related to device miniaturization, performance improvement and point-of-care applications round out discussions. Final sections cover future challenges, the prospects of various techniques, and how the introduction of nanotechnology in cancer management in a personalized manner is useful. Includes smart sensing materials such as smart electro-active nanomaterials, sensitive transducers development, nano-enabled advanced imaging, miniaturized analytical system, and device integration and interfacing for point-of-care applications Describes each component involved in the development of an efficient cancer diagnostics system Focuses on fundamental and applied concepts of the technologies, along with the related mechanisms proposed for diagnostics of cancer Enhances fundamental understandings of the concepts and development of nanotechnology based analytical tools and novel techniques for early stage cancer diagnostics and management

Advances in Clinical Chemistry

Advances in Clinical Chemistry Book
Author : Gregory S. Makowski
Publisher : Academic Press
Release : 2021-03-09
ISBN : 012824416X
Language : En, Es, Fr & De

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Book Description :

Advances in Clinical Chemistry, Volume 101, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this new release including chapters on Exosomes in cancer, Parathyroid hormone, Clinical relevance of biochemical and metabolic changes in osteoarthritis, Early diagnosis with ultrasensitive ELISA, Cytokines and the immune response in obesity-related disorders, Metabolic profiling of organic and fatty acids in chronic and autoimmune diseases, and more. Provides updates on the most current technologies in clinical chemistry and clinical laboratory science Authored by world renowned clinical laboratory scientists, physicians and research scientists Presents the international benchmark for novel analytical approaches in the clinical laboratory

Cancer Immunology and Immunotherapy

Cancer Immunology and Immunotherapy Book
Author : Mansoor M. Amiji,Lara Scheherazade Milane
Publisher : Academic Press
Release : 2021-08-18
ISBN : 012823637X
Language : En, Es, Fr & De

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Book Description :

Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO

Epidemiology of Brain and Spinal Tumors

Epidemiology of Brain and Spinal Tumors Book
Author : Jahangir Moini,Nicholas Avgeropoulos,Mohtashem Samsam
Publisher : Academic Press
Release : 2021-04-16
ISBN : 0128217553
Language : En, Es, Fr & De

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Book Description :

Epidemiology of Brain and Spinal Tumors provides a single volume resource on imaging methods and neuroepidemiology of both brain and spinal tumors. The book covers a variety of imaging techniques, including computed tomography (CT), MRI, positron emission tomography (PET), and other laboratory tests used in diagnosis and treatment. Detailed epidemiology, various imaging methods, and clinical considerations of tumors of the CNS make this an ideal reference for users who will also find diverse information about structures and functions, cytology, epidemiology (including molecular epidemiology), diagnosis and treatment. This book is appropriate for neuroscience researchers, medical professionals and anyone interested in a complete guide to visualizing and understanding CNS tumors. Provides the most up-to-date information surrounding the epidemiology, biology and imaging techniques for brain and spinal tumors, including CT, MRI, PET, and others Includes full color figures, photos, tables, graphs and radioimaging Contains information that will be valuable to anyone interested in the field of neurooncology and the treatment of patients with brain and spinal tumors Serves as a source of background information for basic scientists and pharmaceutical researchers who have an interest in imaging and treatment

Systemic Drug Delivery Strategies

Systemic Drug Delivery Strategies Book
Author : Mansoor M. Amiji,Lara Scheherazade Milane
Publisher : Academic Press
Release : 2021-08-21
ISBN : 0323909256
Language : En, Es, Fr & De

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Book Description :

Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 examines the challenges of delivering immuno-oncology therapies, focusing specifically on the multiple technologies of affective drug delivery strategies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses methods of targeting tumors, CRISPR technology, and vaccine delivery among many other delivery strategies. Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO

Engineering Technologies and Clinical Translation

Engineering Technologies and Clinical Translation Book
Author : Mansoor M. Amiji,Lara Scheherazade Milane
Publisher : Academic Press
Release : 2021-08-25
ISBN : 0323909507
Language : En, Es, Fr & De

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Book Description :

Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies, focusing specifically on the development of solutions for drug delivery and its clinical outcomes. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses biomaterial, microfluidic, and biodegradable devices, engineered microbes, personalized medicine, clinical approval process, and many other IO technologies. Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Explores engineering technologies and their clinical translation in a comprehensive way Presents forecasting on the future of nanotechnology and drug delivery for IO Engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side

Organelle and Molecular Targeting

Organelle and Molecular Targeting Book
Author : Lara Scheherazade Milane,Mansoor M. Amiji
Publisher : CRC Press
Release : 2021-12-29
ISBN : 1000505936
Language : En, Es, Fr & De

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Book Description :

We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines, such as the mRNA vaccines encoding the viral spike protein, demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed, the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community, allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile, degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA, DNA, and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear, and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example, using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines, reducing the required dose and therefore the biomanufacturing demand. Likewise, improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets, but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example, mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies, cancer, neurodegeneration, progerias, diabetes, and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status, demand, and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students, scientists, and clinicians contributing to modern medicine.

Mesenchymal Stem Cell Derived Exosomes

Mesenchymal Stem Cell Derived Exosomes Book
Author : Yaoliang Tang,Buddhadeb Dawn
Publisher : Academic Press
Release : 2015-09-02
ISBN : 0128004975
Language : En, Es, Fr & De

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Book Description :

Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

MicroRNA in Regenerative Medicine

MicroRNA in Regenerative Medicine Book
Author : Chandan K. Sen
Publisher : Elsevier
Release : 2014-11-26
ISBN : 0124058582
Language : En, Es, Fr & De

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Book Description :

This work encapsulates the uses of miRNA across stem cells, developmental biology, tissue injury and tissue regeneration. In particular contributors provide focused coverage of methodologies, intervention and tissue engineering. Regulating virtually all biological processes, the genome’s 1048 encoded microRNAs appear to hold considerable promise for the potential repair and regeneration of tissues and organs in future therapies. In this work, 50 experts address key topics of this fast-emerging field. Concisely summarizing and evaluating key findings emerging from fundamental research into translational application, they point to the current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA across repair and regeneration, and special coverage of methodologies and interventions as they point towards organ and tissue engineering Multi-colour text layout with 150 colour figures to illustrate important findings Take home messages encapsulate key lessons throughout text Short chapters offer focused discussion and clear ‘voice’

Advances in Cell and Molecular Diagnostics

Advances in Cell and Molecular Diagnostics Book
Author : Pongali Raghavendra,Thammineni Pullaiah
Publisher : Academic Press
Release : 2018-01-10
ISBN : 0128136804
Language : En, Es, Fr & De

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Book Description :

Advances in Cell and Molecular Diagnostics brings the scientific advances in the translation and validation of cellular and molecular discoveries in medicine into the clinical diagnostic setting. It enumerates the description and application of technological advances in the field of cellular and molecular diagnostic medicine, providing an overview of specialized fields, such as biomarker, genetic marker, screening, DNA-profiling, NGS, cytogenetics, transcriptome, cancer biomarkers, prostate specific antigen, and biomarker toxicologies. In addition, it presents novel discoveries and clinical pathologic correlations, including studies in oncology, infectious diseases, inherited diseases, predisposition to disease, and the description or polymorphisms linked to disease states. This book is a valuable resource for oncologists, practitioners and several members of the biomedical field who are interested in understanding how to apply cutting-edge technologies into diagnostics and healthcare. Encompasses the current scientific advances in the translation and validation of cellular and molecular discoveries into the clinical diagnostic setting Explains the application of cellular and molecular diagnostics methodologies in clinical trials Focuses on translating preclinical tests to the bedside in order to help readers apply the most recent technologies to healthcare

Nanomedicines

Nanomedicines Book
Author : Anonim
Publisher : BoD – Books on Demand
Release : 2019-02-13
ISBN : 1789852838
Language : En, Es, Fr & De

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Book Description :

Nanomedicine is the application of nanotechnology in medicines at an atomic, molecular, and supramolecular level. Nanomedicine covers a wide range of topics from the development of nanomaterials for use in medicines to the synthesis of nanomedicines with their multiple applications. The major focus of the book is on developments in nanomedicines and their effectiveness compared to conventional drugs. Some drugs are administered twice daily for days and weeks. However, the frequency of administration and dosage of drugs can be reduced to increase patient compliance when prepared at the nanoscale level with polymers, etc. This book contains five chapters from leading scientists working in the area of nanomedicines. Particular topics that are highlighted are exosomes, nanoantimicrobial solutions, transethosomes, nanoethosomes, nanoparticles, multifunctional drugs, and natural dietary products.

Head Neck Cancer and Esophageal Cancer From Biosignatures to Therapeutics

Head   Neck Cancer and Esophageal Cancer  From Biosignatures to Therapeutics Book
Author : Victor C. Kok,Cheng-Chia Yu,Jorge A. R. Salvador
Publisher : Frontiers Media SA
Release : 2021-05-11
ISBN : 2889667596
Language : En, Es, Fr & De

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Book Description :

Download Head Neck Cancer and Esophageal Cancer From Biosignatures to Therapeutics book written by Victor C. Kok,Cheng-Chia Yu,Jorge A. R. Salvador, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Impact of Tumor Extracellular Matrix Cross Talk on Cancer Hallmarks

The Impact of Tumor Extracellular Matrix Cross Talk on Cancer Hallmarks Book
Author : Hamid Morjani,Fawzi Aoudjit,Nils Cordes,Monique Dontenwill,Rafael Fridman,Erik Maquoi,Frederic Saltel,Sophie Tartare-Deckert
Publisher : Frontiers Media SA
Release : 2021-04-05
ISBN : 288966659X
Language : En, Es, Fr & De

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Book Description :

Download The Impact of Tumor Extracellular Matrix Cross Talk on Cancer Hallmarks book written by Hamid Morjani,Fawzi Aoudjit,Nils Cordes,Monique Dontenwill,Rafael Fridman,Erik Maquoi,Frederic Saltel,Sophie Tartare-Deckert, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Novel clinical applications of extracellular vesicles

Novel clinical applications of extracellular vesicles Book
Author : Matías Sáenz-Cuesta, David Otaegui,Maria Mittelbrunn
Publisher : Unknown
Release : 2015-08-14
ISBN : 2889196453
Language : En, Es, Fr & De

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Book Description :

During the last years, the research on extracellular vesicles (EVs) has raised giving new insights into pathophysiology of several diseases. EVs are membrane-bound particles secreted by almost all cell types. Depending on their biogenesis and size they include exosomes, microparticles / microvesicles and apoptotic bodies. Characteristically, EVs carry markers from the source cell membrane and contain genetic material, lipids and proteins inside. They are known to play a role in cell-to-cell communication and to produce genotypic and phenotypic modifications in the target cell including: antigen presentation, apoptosis induction, cellular activation, inhibition or differentiation. In particular, increasing concentrations of EVs have been found in many diseases such as cancer, autoimmune and cardiovascular diseases, among others. Most of the studies in EVs are focused on the characterization of EVs compounds, identifying mechanism of action, their potential use as biomarkers, and few of them investigate a therapeutic usage. However, there are some issues to be achieved on the path to their clinical application. This research topic offers a common place to discuss current and novel clinical applications of EVs pointing on future directions. We encouraged the submission of original articles, reviews, hypothesis, controversies, future perspectives and personal viewpoints on the following topics of interest, but not limited to: • Contribution of EVs to better understand the pathology of immunological diseases. • Standardization of isolation and quantification protocols in the daily clinical practice. • Possible applications of EVs as clinical biomarkers (diagnostic, prognostic and evolution marker). • Therapeutic role of EVs being vehicles of specific cargo: current clinical trials? • Novel immunological functions of EVs.

Colon Cancer Diagnosis and Therapy

Colon Cancer Diagnosis and Therapy Book
Author : Naveen Kumar Vishvakarma
Publisher : Springer Nature
Release : 2022-01-20
ISBN : 3030646688
Language : En, Es, Fr & De

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Book Description :

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the second of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

Silica Nanostructure Platform for Affinity Capture of Tumorderived Exosomes and Other Biomedical Applications of Nanomaterials

Silica Nanostructure Platform for Affinity Capture of Tumorderived Exosomes and Other Biomedical Applications of Nanomaterials Book
Author : Parissa Ziaei
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The integration of nanotechnology with medicine has revolutionized the twentieth century and can be developed into categories of diagnostic devices, contrast agents, sensors, physical therapy applications, and drug delivery vehicles. My research has focused mostly on the development of a diagnostic technique to monitor the progression of prostate cancer and early diagnosis of cancer. Biofunctionalized silica nanospring mats were prepared to selectivity capture tumor-derived exosomes through the interaction of the ligand with prostate-specific membrane antigen on the exosomes. The result obtained from biocinchonic acid assay shows high capture efficiency for the ligand-activated silica nanostructures. The silica nanostructures provide a high surface area support for immobilization of biomolecules and the open structure of the mats improves the accessibility of the flowing solvent. Tumor-derived exosomes are secreted by cancerous known as a new resource for the biomarker to facilitate early diagnosis via a non-invasive procedure. This proposed work is expected to accelerate the discovery of diagnostic or prognostic biomarkers. Another application of nanotechnology has been investigated in chapter 4 and 5. The potential of a nanoparticle delivery system has been evaluated to improve methods of delivery of candidate peptide-based vaccines for paratuberculosis. Poly (lactic-co-glycolic acid) nanoparticles vector containing the peptide elicit the development of cytotoxic T cells with the ability to kill intracellular mycobacterium avium ssp. Paratuberculosis which is the causative agent of Johne's disease. The pathogen has a broad host range that includes ruminants and non-ruminant species, including humans. Because Johne's disease is so difficult to diagnose before it progresses to clinical disease, vaccination is the only viable approach for safeguarding cattle and humans from the dangerous effects of paratuberculosis.

Perspectives in Primary Prevention Research for Breast Cancer A Focus on Gene Environment Interactions

Perspectives in Primary Prevention Research for Breast Cancer  A Focus on Gene   Environment Interactions Book
Author : Sophie A. Lelièvre,Rabih Shakib Talhouk,Victoria Seewaldt,Mary Beth Terry,Martine Marie Bellanger
Publisher : Frontiers Media SA
Release : 2021-04-16
ISBN : 2889666980
Language : En, Es, Fr & De

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Book Description :

Download Perspectives in Primary Prevention Research for Breast Cancer A Focus on Gene Environment Interactions book written by Sophie A. Lelièvre,Rabih Shakib Talhouk,Victoria Seewaldt,Mary Beth Terry,Martine Marie Bellanger, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Early Detection and Treatment of Head Neck Cancers

Early Detection and Treatment of Head   Neck Cancers Book
Author : Rami El Assal,Dyani Gaudilliere,Stephen Thaddeus Connelly
Publisher : Springer Nature
Release : 2021-05-07
ISBN : 3030698599
Language : En, Es, Fr & De

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Book Description :

Head and neck cancer (HNC) is a heterogeneous group of cancers that, if combined, represent one of the most common cancer types. Patients with HNC suffer significant morbidity and mortality due to the importance of the structures involved. Over two-thirds of these patients are diagnosed at a late stage, leading to a poor prognosis. Therefore, advancements in early detection and treatment of HNC are crucial. Volume I begins with a general overview, including the industry landscape, of HNC detection, diagnosis, and treatment. Next, it covers the applications of innovative technologies such as microfluidics, nanotechnology, and deep learning to early detect as well as study HNC. For example, studying the cellular features at a single-cell level became possible with the advancement of technologies such as mass cytometry or specifically, Cytometry by Time Of Flight Mass Spectrometry (CyTOF), which has revolutionized the way we can study complex human diseases such as HNC. Finally, the last few chapters are dedicated to describing the standard of care of HNC. The first volume of Early Detection and Treatment of Head & Neck Cancers is highly pertinent to the next generation of interdisciplinary clinicians, scientists, residents, and students who are particularly interested in HNC and in the translation of early detection methods, technologies, and research to clinical practice.

Tumor Microenvironment

Tumor Microenvironment Book
Author : Alexander Birbrair
Publisher : Springer Nature
Release : 2020-10-29
ISBN : 3030502244
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including MicroRNAs, estrogen, Caveolin-1, Nitric Oxide, RANK/RANKL signaling, , COX-2 Signaling, Renin–angiotensin system, and more. Taken alongside its companion volumes, Tumor Microenvironment: Molecular Players – Part B updates us on what we know about the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.