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Developmental And Fetal Origins Of Differences In Monozygotic Twins

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Developmental and Fetal Origins of Differences in Monozygotic Twins

Developmental and Fetal Origins of Differences in Monozygotic Twins Book
Author : Alexandra Matias,Isaac Blickstein
Publisher : Academic Press
Release : 2020-05-15
ISBN : 0128203072
Language : En, Es, Fr & De

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Book Description :

Developmental and Fetal Origins of Differences in Monozygotic Twins: From Genetics to Environmental Factors examines the major causes of discordance in monozygotic twins, from genetic, to environmental influences, including discussions on the genetic, epigenetic, fetal and environmental factors. Twin differences discussed include malformations, deformations and disruptions secondary to inequitable division of the early embryo, chromosome and single gene mosaicism, Nonrandom X chromosome inactivation, mitochondrial heteroplasmy, epigenetic variation, and variable and inequitable blood supply, among other influences. Differences in hemoglobin levels, placentation and amniotic fluid are also examined, while full color images illustrate discordant anomalies and twin differences throughout. Examines the major causes of discordance in monozygotic twins and their relevance for future studies and clinical management Discusses NIPT in MZ twins, twin imaging during fetal development, blood tests and forensic analysis Features contributions from international experts in twin genetics and developmental biology

Perinatology

Perinatology Book
Author : Renato Augusto Moreira de Sá
Publisher : Springer Nature
Release : 2022-07-05
ISBN : 3030834344
Language : En, Es, Fr & De

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Book Description :

Download Perinatology book written by Renato Augusto Moreira de Sá, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Multifaceted Genes in Amyotrophic Lateral Sclerosis Frontotemporal Dementia

Multifaceted Genes in Amyotrophic Lateral Sclerosis Frontotemporal Dementia Book
Author : Henry Houlden,Alan Edward Renton,Francesca Luisa Conforti
Publisher : Frontiers Media SA
Release : 2021-06-28
ISBN : 2889669041
Language : En, Es, Fr & De

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Book Description :

Download Multifaceted Genes in Amyotrophic Lateral Sclerosis Frontotemporal Dementia book written by Henry Houlden,Alan Edward Renton,Francesca Luisa Conforti, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Exploring the Biological Contributions to Human Health

Exploring the Biological Contributions to Human Health Book
Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Understanding the Biology of Sex and Gender Differences
Publisher : National Academies Press
Release : 2001-07-02
ISBN : 9780309132978
Language : En, Es, Fr & De

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Book Description :

It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.

Medical Epigenetics

Medical Epigenetics Book
Author : Anonim
Publisher : Academic Press
Release : 2021-08-27
ISBN : 0128243260
Language : En, Es, Fr & De

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Book Description :

Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a broad spectrum of disease categories and specialties, and with a focus on human systems, epigenetic diseases that affect these systems, and evolving modes of epigenetic-based treatment. Here, more than 40 leading researchers examine how each human system is affected by epigenetic maladies, offering an all-in-one resource on medical epigenetics not only for those directly involved with health care, but investigators in life sciences, biotech companies, graduate students, and others who are interested in applied aspects of epigenetics. Incorporating both diagnostic and prognostic epigenetic approaches, this volume also fully supports the application of epigenetics in precision medicine. This second edition of Medical Epigenetics, a volume in the Translational Epigenetics series, has been fully revised to address recent advances in disease epigenetics and role of epigenetics in precision medicine, with all-new chapters on skin cancer epigenetics, network analysis in medical epigenetics, machine learning in epigenetic diseases, and clinical trials of epigenetics drugs. Features chapters from leading researchers and clinicians dedicated to the burgeoning role of epigenetics in medical practice Covers emerging topics, including twin epigenetics, as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Organized from system disorders to multi-system disorders that involve epigenetic aberrations Examines the role of epigenetics in precision medicine

Old and New Perspectives on Mortality Forecasting

Old and New Perspectives on Mortality Forecasting Book
Author : Tommy Bengtsson,Nico Keilman
Publisher : Springer
Release : 2019-03-28
ISBN : 3030050750
Language : En, Es, Fr & De

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Book Description :

This open access book describes methods of mortality forecasting and discusses possible improvements. It contains a selection of previously unpublished and published papers, which together provide a state-of-the-art overview of statistical approaches as well as behavioural and biological perspectives. The different parts of the book provide discussions of current practice, probabilistic forecasting, the linearity in the increase of life expectancy, causes of death, and the role of cohort factors. The key question in the book is whether it is possible to project future mortality accurately, and if so, what is the best approach. This makes the book a valuable read to demographers, pension planners, actuaries, and all those interested and/or working in modelling and forecasting mortality.

Placental Fetal Growth Restriction

Placental Fetal Growth Restriction Book
Author : Christoph Lees,Gerard H. A. Visser,Kurt Hecher
Publisher : Cambridge University Press
Release : 2018-08-02
ISBN : 1107101395
Language : En, Es, Fr & De

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Book Description :

Master the effective evaluation of placental-fetal growth restriction (PFGR), whilst reducing the risk of perinatal mortality and morbidity in patients worldwide.

Gamete and Embryo fetal Origins of Adult Diseases

Gamete and Embryo fetal Origins of Adult Diseases Book
Author : He-Feng Huang,Jian-Zhong Sheng
Publisher : Springer Science & Business Media
Release : 2013-11-19
ISBN : 9400777728
Language : En, Es, Fr & De

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Book Description :

The book Gamete and Embryo-fetal Origins of Adult Diseases introduces various diseases resulting from the abnormal gametogenesis and embryo development, which manifests as growth retardation, birth defects, or increased susceptibility to chronic metabolic diseases such as diabetes, cardiovascular disease and cancer in childhood and adult life, even fertility disorders and the risk of transgenerational transmission. Six common kinds of these diseases are discussed in separate chapters. The authors explore the connections between these diseases and epigenetic reprogramming, rapid cell differentiation and organ formation and environmental influences, including assisted reproductive technology and adverse intrauterine environments. With a summary of findings on the causes and progression of adult diseases at the phase of gametogenesis and embryo development, this book provides insights into the pathogenesis of disease and aids in the treatment and prevention of disease, meeting the requirement for improving the quality of the newborn population, and effectively preventing and curing major diseases at an early stage. This book offers new perspectives and will be an enlightening resource for obstetricians, paediatricians, epidemiologists, endocrinologists and sanitarians. Editor He-Feng Huang, M.D., is Professor and President of Women’s Hospital, School of Medicine, Zhejiang University, China. Editor Jian-Zhong Sheng, Ph.D., is Professor at the Department of Pathology & Pathophysiology, School of Medicine, Zhejiang University, China.

Deliberately Divided

Deliberately Divided Book
Author : Nancy L Segal
Publisher : Rowman & Littlefield
Release : 2021-10-15
ISBN : 1538132869
Language : En, Es, Fr & De

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Book Description :

In Deliberately Divided, Nancy Segal revisits a controversial study that tracked the development of separated twins and triplets. None of the adoptive parents were told that they were raising a multiple birth baby. The truth was shocking for these parents and twins, many of whom have shared their unimaginable stories for the first time.

RUNX Proteins in Development and Cancer

RUNX Proteins in Development and Cancer Book
Author : Yoram Groner,Yoshiaki Ito,Paul Liu,James C. Neil,Nancy A. Speck,Andre van Wijnen
Publisher : Springer
Release : 2017-03-15
ISBN : 9811032335
Language : En, Es, Fr & De

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Book Description :

This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy. The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both ‘gatekeepers’ that modulate p53 responses and ‘caretakers’ that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV. At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy. This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists.

Family matters

Family matters Book
Author : Deborah A. Lawlor,Gita D. Mishra
Publisher : OUP Oxford
Release : 2009-04-02
ISBN : 0191575224
Language : En, Es, Fr & De

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Book Description :

Family-based studies, including intergenerational, sibling, and twin studies, are increasingly being used to explore life course epidemiology. However, there are issues relating to study design and the statistical analysis of family-based studies that are still not well understood, and comprehending the underlying assumptions of these studies and drawing the inferences from them can be complex. This book provides the knowledge and skills required to design, analyse, and correctly interpret family-based studies. It explains what these studies can tell us about life course epidemiology; provides practical guidance on how to set-up and maintain birth cohorts for completing family-based studies in life course epidemiology; describes how to undertake appropriate statistical analyses of family-based studies and correctly interpret results from these analyses; and provides examples that illustrate the ways in which family-based studies can enhance our understanding of life course epidemiology. In addition, there is discussion of difficulties specific to setting up such studies in low- and middle-income countries, and issues relating to proxy informants, where parents provide information on children and vice versa, or siblings provide information about each other. Examples of how family-based studies have been used in understanding the life course epidemiology of cardiovascular disease, mental health, and reproductive health illustrate the applicability of the research to these areas, but also more generally to the wider field of life course epidemiology.

Transforming the Workforce for Children Birth Through Age 8

Transforming the Workforce for Children Birth Through Age 8 Book
Author : National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on the Science of Children Birth to Age 8: Deepening and Broadening the Foundation for Success
Publisher : National Academies Press
Release : 2015-07-23
ISBN : 0309324882
Language : En, Es, Fr & De

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Book Description :

Children are already learning at birth, and they develop and learn at a rapid pace in their early years. This provides a critical foundation for lifelong progress, and the adults who provide for the care and the education of young children bear a great responsibility for their health, development, and learning. Despite the fact that they share the same objective - to nurture young children and secure their future success - the various practitioners who contribute to the care and the education of children from birth through age 8 are not acknowledged as a workforce unified by the common knowledge and competencies needed to do their jobs well. Transforming the Workforce for Children Birth Through Age 8 explores the science of child development, particularly looking at implications for the professionals who work with children. This report examines the current capacities and practices of the workforce, the settings in which they work, the policies and infrastructure that set qualifications and provide professional learning, and the government agencies and other funders who support and oversee these systems. This book then makes recommendations to improve the quality of professional practice and the practice environment for care and education professionals. These detailed recommendations create a blueprint for action that builds on a unifying foundation of child development and early learning, shared knowledge and competencies for care and education professionals, and principles for effective professional learning. Young children thrive and learn best when they have secure, positive relationships with adults who are knowledgeable about how to support their development and learning and are responsive to their individual progress. Transforming the Workforce for Children Birth Through Age 8 offers guidance on system changes to improve the quality of professional practice, specific actions to improve professional learning systems and workforce development, and research to continue to build the knowledge base in ways that will directly advance and inform future actions. The recommendations of this book provide an opportunity to improve the quality of the care and the education that children receive, and ultimately improve outcomes for children.

Scientific and Medical Aspects of Human Reproductive Cloning

Scientific and Medical Aspects of Human Reproductive Cloning Book
Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Policy and Global Affairs,Committee on Science, Engineering, and Public Policy
Publisher : National Academies Press
Release : 2002-06-17
ISBN : 0309076374
Language : En, Es, Fr & De

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Book Description :

Human reproductive cloning is an assisted reproductive technology that would be carried out with the goal of creating a newborn genetically identical to another human being. It is currently the subject of much debate around the world, involving a variety of ethical, religious, societal, scientific, and medical issues. Scientific and Medical Aspects of Human Reproductive Cloning considers the scientific and medical sides of this issue, plus ethical issues that pertain to human-subjects research. Based on experience with reproductive cloning in animals, the report concludes that human reproductive cloning would be dangerous for the woman, fetus, and newborn, and is likely to fail. The study panel did not address the issue of whether human reproductive cloning, even if it were found to be medically safe, would beâ€"or would not beâ€"acceptable to individuals or society.

Epigenetic Epidemiology

Epigenetic Epidemiology Book
Author : Karin B. Michels
Publisher : Springer Science & Business Media
Release : 2012-01-02
ISBN : 9400724950
Language : En, Es, Fr & De

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Book Description :

The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!

Twin Studies

Twin Studies  Book
Author : Grant C Townsend,Sandra K Pinkerton,James R Rogers,Michelle R Bockmann,Toby E Hughes
Publisher : University of Adelaide Press
Release : 2015-10-08
ISBN : 1925261158
Language : En, Es, Fr & De

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Book Description :

This volume is about an ongoing long-term research initiative led by researchers from the School of Dentistry at the University of Adelaide. The aim of this book is to provide an overview of the studies of the teeth and faces of Australian twins and their families that have extended over more than thirty years.

Fanaroff and Martin s Neonatal Perinatal Medicine

Fanaroff and Martin s Neonatal Perinatal Medicine Book
Author : Richard J. Martin,Avroy A. Fanaroff,Michele C. Walsh
Publisher : Elsevier Health Sciences
Release : 2019-04-11
ISBN : 0323567096
Language : En, Es, Fr & De

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Book Description :

Trusted by physicians and advanced practice providers through ten standard-setting editions, Fanaroff and Martin's Neonatal-Perinatal Medicine, 11th Edition, remains the reference of choice for expert, multidisciplinary guidance on the management and evidence-based treatment of problems in the mother, fetus, and neonate. An expanded team of international authors, led by Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh of Rainbow Babies and Children's Hospital, brings you up to date with advances in the control of nosocomial infections in preterm infants, genetic disorders and birth defects, the fetal origins of adult disease, the late preterm infants, and much more – all designed to help you improve the quality of life and long-term outcomes of your patients. Helps you make informed clinical choices for each patient – from diagnosis and treatment selection through post-treatment strategies and management of complications – with a dual focus on neonatology and perinatology. Includes a new chapter on Social and Economic Contributors to Neonatal Outcome. Features extensive updates and reorganization throughout, with new Key Points at the end of each chapter Provides up-to-date, evidence-based content, with more information on precision medicine and genetics. Uses detailed, full-color illustrations that depict disorders in the clinical setting and explain complex information. Remains the most comprehensive, multidisciplinary text in the field – an excellent source of information for every stage of your practice.

Born Together Reared Apart

Born Together   Reared Apart Book
Author : Nancy L. Segal
Publisher : Harvard University Press
Release : 2012-06-18
ISBN : 0674065158
Language : En, Es, Fr & De

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Book Description :

The Minnesota Study of Twins Reared Apart startled scientists by demonstrating that twins reared apart are as alike, across a number of personality traits and other measures, as those raised together, suggesting that genetic influence is pervasive. Segal offers an overview of the study’s scientific contributions and effect on public consciousness.

Twins From Fetus to Child

Twins   From Fetus to Child Book
Author : Alessandra Piontelli
Publisher : Routledge
Release : 2012-09-10
ISBN : 1134504942
Language : En, Es, Fr & De

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Book Description :

Though much has been written about twins, very little research has been done into their everyday lives, both postnatal and prenatal. In this fascinating new study Alessandra Piontelli follows the development and behaviour of thirty pairs of twins from their early life in the womb through to their third year of childhood. Drawing on detailed ultrasound observations and work with mothers and families in clinical and natural settings, the text traces the subtle ways in which various types of twins live, behave and interact with their unequally shared and unique pre- and postnatal environments. Piontelli shows how from early on distinctive and personal traits can be seen in the behaviour of each member of a twin couple and how these traits continue and strengthen well beyond birth. The book describes not only the behaviour of the twins, but the impact they have on the lives of their family and carers - what family members say, how they react and how the family changes. Scientifically based, but warmly human in content, this unique longitudinal study offers new insight for professionals working with mothers and families of twins and for researchers in human development across a range of disciplines.

Handbook of Behavior Genetics

Handbook of Behavior Genetics Book
Author : Yong-Kyu Kim
Publisher : Springer Science & Business Media
Release : 2009-03-25
ISBN : 0387767274
Language : En, Es, Fr & De

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Book Description :

This handbook provides research guidelines to study roles of the genes and other factors involved in a variety of complex behaviors. Utilizing methodologies and theories commonly used in behavior genetics, each chapter features an overview of the selected topic, current issues, as well as current and future research.

Fanaroff and Martin s Neonatal Perinatal Medicine E Book

Fanaroff and Martin s Neonatal Perinatal Medicine E Book Book
Author : Richard J. Martin,Avroy A. Fanaroff,Michele C. Walsh
Publisher : Elsevier Health Sciences
Release : 2014-08-20
ISBN : 0323295371
Language : En, Es, Fr & De

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Book Description :

Tackle your toughest challenges and improve the quality of life and long-term outcomes of your patients with authoritative guidance from Fanaroff and Martin s Neonatal-Perinatal Medicine. Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh and a contributing team of leading experts in the field deliver a multi-disciplinary approach to the management and evidence-based treatment of problems in the mother, fetus and neonate. New chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors keep you current on the late preterm infant, the fetal origins of adult disease, neonatal anemia, genetic disorders, and more. "...a valuable reference book and a pleasure to read." Reviewed by BACCH Newsletter, Mar 2015 Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Be certain with expert, dependable, accurate answers for every stage of your career from the most comprehensive, multi-disciplinary text in the field! See nuance and detail in full-color illustrations that depict disorders in the clinical setting and explain complex information. Obtain more global perspectives and best practices with contributions from international leaders in the field of neonatal-perinatal medicine. Get comprehensive guidance on treating patients through a dual focus on neonatology and perinatology. Spot genetic problems early and advise parents of concerns, with a completely new section on this topic. Make informed clinical choices for each patient, from diagnosis and treatment selection through post-treatment strategies and management of complications, with new evidence-based criteria throughout. Stay at the forefront of your field thanks to new and completely revised chapters covering topics such as: Principles and Practice l Immune and Non-immune Hydrops Fetalis l Amniotic Fluid Volume l Enhancing Safe Prescribing in the Neonatal Intensive Care Unit l Role of Imaging in Neurodevelopmental Outcomes of High-Risk Neonates l Patent Ductus Arteriosus l Gastroesophageal Reflux and Gastroesophageal Reflux Diseases in the Neonate. Find and grasp the information you need easily and rapidly with indexing that provides quick access to specific guidance.