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Developing Costimulatory Molecules For Immunotherapy Of Diseases

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Developing Costimulatory Molecules for Immunotherapy of Diseases

Developing Costimulatory Molecules for Immunotherapy of Diseases Book
Author : Manzoor Ahmad Mir
Publisher : Academic Press
Release : 2015-05-25
ISBN : 0128026758
Language : En, Es, Fr & De

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Book Description :

Developing Costimulatory Molecules for Immunotherapy of Diseases highlights the novel concept of reverse costimulation and how it can be effectively exploited to develop immunotherapy using either humanized antibodies against CD80, CD86, and other costimulatory molecules or CD28 fusinogenic proteins in the treatment of diseases, including allergies, asthma, rheumatoid arthritis, multiple sclerosis, lupus nephritis, severe psoriasis, vulgaris tuberculosis, thopoid, transplantation therapeutic, cancer, and inflammation. The text aims to provide the latest information on the complex roles and interactions within the CD28 and B7 costimulatory families, with the hope that targeting these families will yield new therapies for the treatment of inflammation, autoimmunity, transplantation, cancer, and other infectious diseases. Highlights the novel concept of reverse costimulation and how it can be effectively exploited to develop immunotherapy Provides the latest information on the complex roles and interactions within the CD28 and B7 costimulatory families Targets new therapies for the treatment of inflammation, autoimmunity, transplantation, cancer, and other infectious diseases

Nanoformulation Strategies for Cancer Treatment

Nanoformulation Strategies for Cancer Treatment Book
Author : Sarwar Beg,Mahfoozur Rahman,Hani Choudhry,Eliana B. Souto,Farhan J. Ahmad
Publisher : Elsevier
Release : 2020-11-20
ISBN : 0128210966
Language : En, Es, Fr & De

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Book Description :

Nanoformulation Strategies for Cancer Treatment provides an up-to-date review on current developments and regulatory and clinical challenges in the field of nanopharmaceuticals and the effective treatment of diverse varieties of cancer. This important reference source is ideal for biomaterials scientists and pharmaceutical scientists working in the area of cancer diagnosis and therapy. Due to the high cost of traditional cancer treatment types, researchers have increasingly looked for new ways to augment the therapeutic performance of existing drug candidates. The use of nanotechnology-based approaches have gained significant momentum, thus leading to the launch of a series of new drug products. As nanopharmaceuticals improve the therapeutic performance of cancer therapy drugs, but also provide opportunities for site-specific drug targeting in tumors, this work is a welcomed resource on the topics discussed. Highlights the application of nanoformulations, including liposomes, nanoparticles and nanobiomaterials for targeted drug delivery to cancer cells Explores recent advances made using novel nanoformulations containing herbal drugs and biotechnology based therapeutic strategies for cancer treatment Assesses the regulatory hurdles that are necessary for the successful clinical translation of nanomedicines from the laboratory into the market

Oncology

Oncology Book
Author : Anonim
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Oncology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Journal of Immunology

The Journal of Immunology Book
Author : Anonim
Publisher : Unknown
Release : 2008-12
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Immunotherapy in Translational Cancer Research

Immunotherapy in Translational Cancer Research Book
Author : Laurence J. N. Cooper,Elizabeth A. Mittendorf,Judy Moyes,Sabitha Prabhakaran
Publisher : John Wiley & Sons
Release : 2018-02-08
ISBN : 1118684508
Language : En, Es, Fr & De

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Book Description :

A guide to state-of-the-art cancer immunotherapy in translational cancer research A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues. Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world’s foremost cancer research and care center and: Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care Filled with the concepts, examples, and approaches for developing individualized therapy Explores the breath of treatments that reflect the complexity of the immune system itself Includes contributions from a panel international experts in the field of immunotherapy Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.

Development of Polymeric Nanoparticle Vaccines for Immunostimulation

Development of Polymeric Nanoparticle Vaccines for Immunostimulation Book
Author : Pamela Antonia Basto,Harvard--MIT Program in Health Sciences and Technology
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Vaccines have revolutionized medicine by increasing the life expectancy of children and substantially decreasing the morbidity of multiple infectious diseases worldwide. Over several decades, we have acquired significant gains in the understanding of the underlying mechanisms involved in developing protective immunity, yet vaccine development has progressed comparatively slowly. This thesis serves to explore two polymeric nanoparticle platforms to demonstrate the therapeutic potential of synthetic nanocarriers as vaccines with the aim of 1) providing greater spatiotemporal release of small molecule adjuvant to secondary lymphoid sites and 2) providing a tunable surface for loading B cell antigen epitopes in a specific conformation to drive epitope-specific antibody response. In recent decades, TLR mechanisms have been elucidated and novel agonists have been developed, yet our generation still has not seen paramount progress in the clinical translation of these agonists due to risks of systemic toxicity and off target effects. In the first section, we synthesized 223±18 nm poly(lactic-co-glycolic acid)- poly(ethylene glycol)/ poly(lactic acid)-R848 (PLGA-PEG/PLA-R848) nanoparticle vaccine that is designed to deliver a combination of antigen and control release of a small molecule adjuvant R848 (tl/2= 42 hours) to drive a potent antigen-specific immune response. Using ovalbumin as a model protein, this vaccine is able to enhance antigen presentation and co-stimulatory molecules on dendritic cells and subsequently enhanced proliferation of antigen-specific naive CD8+ cells in vitro. Upon vaccination, our delivery system is able to increase cell-mediated and humoral response in comparison to its soluble form, thereby illustrating the potential to bring novel small molecule adjuvants to the clinics. In the second section, we developed a nanoparticle vaccine platform that allows selective orientation of peptide epitopes to enhance B cell response in an application that has therapeutic potential for treatment for cardiovascular disease (CVD). Utilizing epitopes discovered through in silico modeling for human PCSK9, a plasma protein that plays an important role in LDL cholesterol (LDL-c) levels in the blood, our nanoparticle allows selective orientation through biotin-streptavidin conjugation. Upon vaccination with CPG, selected synthetic epitopes conjugated to polymeric nanoparticles trended to reduce serum LDL-c and serum PCSK9 in murine models. Additionally, antibodies in the serum showed promise to increase LDL-receptor levels in HepG2 cells transfected in with WT-hPCSK9 and GOF-hPCSK9 separately suggesting that this vaccine has the potential to reduce risks of CVD. These studies demonstrate that designing polymeric nanoparticles for applications to stimulate the immune system can help define new, cost-effective treatment options in applications for prophylaxis against infectious diseases that are unresponsive to traditional routes of vaccination or for immunotherapy against cardiovascular disease and cancer.

Clinical Immunology

Clinical Immunology Book
Author : Reginald M. Gorczynski,Jacqueline Stanley
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This is a concise text in immunology for medical students. It covers cellular, humoral and clinical immunology. Each chapter begins with a definition of objectives followed by clearly illustrated descriptions of immunologic mechanisms. The clinical implications of the information in each chapter are addressed.

Asthma a Link Between Environment Immunology and the Airways

Asthma  a Link Between Environment  Immunology  and the Airways Book
Author : Hugo E. Neffen
Publisher : Seattle ; Toronto : Hogrefe & Huber
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This volume, released at the Congress, contains the most important papers delivered during the XVIth World Congress of Asthma. Includes current research and details the state of the art in research and clinical aspects of asthma and related diseases. Includes extensive references and halftone illustrations.

Impact Assessment of the Biomedical and Health Research Programme BIOMED 2

Impact Assessment of the Biomedical and Health Research Programme BIOMED 2 Book
Author : European Commission. Directorate General for Research
Publisher : Office for Official Publications of the European Communities
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The Biomedical and Health Research Programme 'BIOMED2' was in operation for four years between 1994-98 with a budget of 360 million ECU. The purpose of the programme was to support the competitiveness of the European scientific research base by participating in cost-sharing research in four key areas: pharmaceuticals, biomedical technology, brain research and human genome research. The overall objective was to promote general health improvements and the transfer of medical research results into medical practice. This publication seeks to assess the impact of BIOMED2 and to identify lessons to be learned for future programmes.

Human Immunology

Human Immunology Book
Author : Ralph M. Steinman
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The recipients of grants from the Dana Human Immunology and Dana Irvington Fellowship Programs are brought together in this volume. In their contributions, the participating scientists summarize their patient-based research in the areas of cancer, infectious disease, allergy, and autoimmunity. Also included are contributions from two guest speakers on B-cell leukemia and autoimmune diabetes.

Hematology

Hematology Book
Author : American Society of Hematology. Education Program
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Hematology book written by American Society of Hematology. Education Program, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cancer Forum

Cancer Forum Book
Author : Anonim
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Advances in Cancer Research

Advances in Cancer Research Book
Author : George F. Vande Woude,George Klein
Publisher : Elsevier
Release : 2011-07-29
ISBN : 9780080464480
Language : En, Es, Fr & De

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Book Description :

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including NY-ESO-1: review of an immunogenic tumor antigen; Order, disorder, death: lessons from a superorganism; Control of differentiation in progression of epithelial tumors; Cancer vaccines: preclinical studies and novel strategies; Clinical results of vaccine therapy for cancer: learning from history for improving the future; Immunodominance and immunodomination: critical factors in developing effective CD8+ T-cell based cancer vaccines; NK cell receptors as tools in cancer immunotherapy; Innate immune recognition and suppression of tumors; Inhibitors of the HSP90 molecular chaperone: current status.

Arzneimittel Forschung

Arzneimittel Forschung Book
Author : Anonim
Publisher : Unknown
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Arzneimittel Forschung book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cancer Research

Cancer Research Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cancer Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Research Report

Research Report Book
Author : Anonim
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Research Report book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cancer Immunotherapy

Cancer Immunotherapy Book
Author : Tyler J. Curiel
Publisher : Springer Science & Business Media
Release : 2012-11-07
ISBN : 1461447321
Language : En, Es, Fr & De

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Book Description :

This work will provide a historical perspective on tumor immunotherapy, discuss fundamental mechanisms of failed tumor rejection, look at passive strategies to boost anti-tumor immunity, as well as have an in-depth look at active strategies to boost anti-tumor immunity.

A Trends Guide to Infectious Diseases

A Trends Guide to Infectious Diseases Book
Author : Paul Hagan
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download A Trends Guide to Infectious Diseases book written by Paul Hagan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Annual report

Annual report Book
Author : National Cancer Institute (U.S.). Division of Cancer Biology, Diagnosis, and Centers
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Annual report book written by National Cancer Institute (U.S.). Division of Cancer Biology, Diagnosis, and Centers, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Indian Journal of Experimental Biology

Indian Journal of Experimental Biology Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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