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Detection Of Drugs And Their Metabolites In Oral Fluid

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Detection of Drugs and Their Metabolites in Oral Fluid

Detection of Drugs and Their Metabolites in Oral Fluid Book
Author : Robert M. White,Christine M. Moore
Publisher : Emerging Issues in Analytical Chemistry
Release : 2018-02
ISBN : 9780128145951
Language : En, Es, Fr & De

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Book Description :

Detection of Drugs and Their Metabolites in Oral Fluid presents the analytical chemistry methods used for the detection and quantification of drugs and their metabolites in human oral fluid. The authors summarize the state of the science, including its strengths, weaknesses, unmet methodological needs, and cutting-edge trends. This volume covers the salient aspects of oral fluid drug testing, including specimen collection and handling, initial testing, point of collection testing (POCT), specimen validity testing (SVT), and confirmatory and proficiency testing. Analytes discussed include amphetamines, cannabinoids, cocaine, opiates, phencyclidine, cannabimimetics, and miscellaneous drugs. This practical guide helps users turn knowledge into practice, moving logically from an outline of the problem, to the evaluation of the appropriateness of oral fluid as a test medium, and finally to a consideration of detection methods and their validation and employment. Compares different collection and testing systems to assist readers involved in clinical or forensic practice in selecting oral fluid as the matrix of choice Provides a sound basis for the detection of drugs and their metabolites in oral fluid and the interpretation of both positive and negative Places the need, or lack thereof, for specimen validity testing and confirmation testing in context with the purposes of oral fluid testing Describes drugs and drug classes that can be tested, along with useful information on a patient/donor's drug status

Detection of Drugs and Their Metabolites in Oral Fluid

Detection of Drugs and Their Metabolites in Oral Fluid Book
Author : Robert M. White,Christine M. Moore
Publisher : Elsevier
Release : 2018-02-23
ISBN : 012814596X
Language : En, Es, Fr & De

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Book Description :

Detection of Drugs and Their Metabolites in Oral Fluid presents the analytical chemistry methods used for the detection and quantification of drugs and their metabolites in human oral fluid. The authors summarize the state of the science, including its strengths, weaknesses, unmet methodological needs, and cutting-edge trends. This volume covers the salient aspects of oral fluid drug testing, including specimen collection and handling, initial testing, point of collection testing (POCT), specimen validity testing (SVT), and confirmatory and proficiency testing. Analytes discussed include amphetamines, cannabinoids, cocaine, opiates, phencyclidine, cannabimimetics, and miscellaneous drugs. This practical guide helps users turn knowledge into practice, moving logically from an outline of the problem, to the evaluation of the appropriateness of oral fluid as a test medium, and finally to a consideration of detection methods and their validation and employment. Compares different collection and testing systems to assist readers involved in clinical or forensic practice in selecting oral fluid as the matrix of choice Provides a sound basis for the detection of drugs and their metabolites in oral fluid and the interpretation of both positive and negative Places the need, or lack thereof, for specimen validity testing and confirmation testing in context with the purposes of oral fluid testing Describes drugs and drug classes that can be tested, along with useful information on a patient/donor’s drug status

Analysis of Cocaine Heroin and Their Metabolites in Saliva

Analysis of Cocaine  Heroin  and Their Metabolites in Saliva Book
Author : David A. Kidwell,NAVAL RESEARCH LAB WASHINGTON DC.
Publisher : Unknown
Release : 1990
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Methods have been developed to analyze for cocaine, heroin and their metabolites in human saliva and the results compared to urinalysis. Analysis of 26 samples showed that 14 positive by urinalysis and 16 positive by saliva analysis. Thus, saliva testing may be competitive to urine testing for detection of drug use. Only a small fraction of the saliva is necessary for the analysis so that further testing may be employed. Also, the metabolite profiles are shown for further analytical development. Keywords: Drugs of abuse, Cocaine, Heroin, Saliva, Urine, Metabolite profiles. (jes).

Drugs of Abuse

Drugs of Abuse Book
Author : Raphael C. Wong,Harley Y. Tse
Publisher : Springer Science & Business Media
Release : 2007-11-05
ISBN : 1592599516
Language : En, Es, Fr & De

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Book Description :

A comprehensive review of the science of drug testing in all its aspects, placing emphasis on technologies that use body fluids other than urine for determining the presence of drugs of abuse. The authors discuss the various body fluid specimens suitable for testing for illicit drugs-particularly saliva, sweat, and hair-describe the structural and manufacturing aspects of on-site testing devices based on lateral flow immunoassay, and detail the pitfalls of using these specimens. They also discuss in detail the problem of sample adulteration and its detection. Since oral fluid has the best potential of succeeding urine as the next matrix of choice for drug detection, four popular saliva testing devices are examined: Intercept®, the Drager Drug Test®, Oratect®, and Drugwipe. Political, social, and legal issues are also considered in articles on privacy, the use of drug testing in courts, and the problem of sample adulteration.

Principles of Forensic Toxicology

Principles of Forensic Toxicology Book
Author : Barry S. Levine,SARAH KERRIGAN
Publisher : Springer Nature
Release : 2020-08-13
ISBN : 3030429172
Language : En, Es, Fr & De

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Book Description :

The fifth edition of the best-selling Principles in Forensic Toxicology continues in the tradition of excellence in academic publishing. With over 10 years of classroom-tested and continually updated content, the new edition contains significant updates and 7 new chapters on new topics including drug-facilitated crimes, derivatization, quantitation, measurement uncertainty/traceability, statistics, oral fluid testing, and drugs in embalmed specimens. Part One covers the major sub-disciplines of forensic toxicology in addition to pharmacological concepts. Part Two addresses specimen preparation, laboratory testing and instrumental analysis, while Part Three discusses common analytes including cocaine, opioids, alcohol, and marijuana. Adopted for courses in many of the top universities for forensic science and used by respected medical examiner’s offices and crime laboratories worldwide, Principles of Forensic Toxicology prepares the next generation of forensic toxicologists and continues to be an important reference in professional practice.

LC MS in Drug Bioanalysis

LC MS in Drug Bioanalysis Book
Author : Q. Alan Xu,Timothy L. Madden
Publisher : Springer Science & Business Media
Release : 2012-07-15
ISBN : 1461438284
Language : En, Es, Fr & De

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Book Description :

Clinical pharmacology plays an important role in today’s medicine. Due to the high sensitivity, selectivity, and affordability of a mass spectrometer (MS), the high performance liquid chromatography – mass spectrometry (LC-MS) analytical technique is widely used in the determination of drugs in human biological matrixes for clinical pharmacology. Specifically, LC-MS is used to analyze: anticancer drugs antidementia drugs antidepressant drugs antiepileptic drugs antifundal drug antimicrobial drugs antipsychotic drugs antiretroviral drugs anxiolytic/hypnotic drugs cardiac drugs drugs for addiction immunosuppressant drugs mood stabilizer drugs This book will primarily cover the various methods of validation for LC-MS techniques and applications used in modern clinical pharmacology.

Liquid Chromatography

Liquid Chromatography Book
Author : C. Kostakis,P. Harpas,P. Stockham
Publisher : Elsevier Inc. Chapters
Release : 2013-01-08
ISBN : 012807115X
Language : En, Es, Fr & De

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Book Description :

Practitioners of forensic toxicology are expected to detect, confirm, and quantify a chemically diverse range of drugs and poisons covering a number of orders of magnitude in concentration in challenging biological matrices. Developments in LC–MS have enabled a wider range of compounds to be analyzed using fewer extraction processes, practically eliminating the requirement for derivatization steps and with fewer instrumental analysis stages. This chapter provides the reader with a broad overview of the current capabilities offered by LC in this branch of analytical chemistry—as well as its limitations.

Handbook of HPLC

Handbook of HPLC Book
Author : Danilo Corradini
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1420016946
Language : En, Es, Fr & De

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Book Description :

High performance liquid chromatography (HPLC) is one of the most widespread analytical and preparative scale separation techniques used for both scientific investigations and industrial and biomedical analysis. Now in its second edition, this revised and updated version of the Handbook of HPLC examines the new advances made in this field since the

Analgesics Advances in Research and Application 2012 Edition

Analgesics   Advances in Research and Application  2012 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-12-26
ISBN : 1481611046
Language : En, Es, Fr & De

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Book Description :

Analgesics—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Analgesics in a concise format. The editors have built Analgesics—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Analgesics in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Analgesics—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

NFL Draft

NFL Draft Book
Author : Anonim
Publisher : PediaPress
Release : 2021-09-26
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download NFL Draft book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Detection of Drug Misuse

Detection of Drug Misuse Book
Author : Kim Wolff
Publisher : Royal Society of Chemistry
Release : 2017-07-05
ISBN : 1788012313
Language : En, Es, Fr & De

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Book Description :

Drug misuse and dependence is an ever evolving field of study, which has exploded over recent years owing to the advent of the internet. Due to the ever-growing number of young people using drugs recreationally and the privatisation of drug screening and detection services, there is the need to disseminate evidence-based information concerning the technology and methods available for studying this expanding field. Detection of Drug Misuse describes the current state-of-the-art techniques used for identifying and confirming drug misuse as well as recent advances in biomarkers, instrumentation and analysis methodology. The title discusses both recreational and designer drugs, including non-addictive and addictive drugs. This book is a useful and fascinating resource for healthcare professionals working in the field of drug misuse as well as academics and postgraduates researching within analytical, chromatography, medicinal and pharmaceutical chemistry; drug metabolism; addiction science; and forensic toxicology, science and medicine.

On Site Drug Testing

On Site Drug Testing Book
Author : Amanda J. Jenkins,Bruce A. Goldberger
Publisher : Springer Science & Business Media
Release : 2002-01-28
ISBN : 1592592724
Language : En, Es, Fr & De

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Book Description :

It is at least a decade since scientists turned their imaginations to creating new compact, portable test instruments and self-contained test kits that could be used to analyze urine and saliva for alcohol, drugs, and their metabolites. Although the potential applications for such tests at the site of specimen collection, now called “on-site” or “point-of-care” testing, range far beyond hospital emergency rooms and law enforcement needs, it was catalyzed by the requirements of workplace drug testing and other drugs-of-abuse testing programs. These programs are now a minor national industry in the United States and in some western European countries, and cover populations as diverse as the military, incarcerated criminals, people suspected of driving under the influence of alcohol and other drugs, all athletes from college to professional ranks, and of course the general employed population, which is monitored for illegal drug use and numbers in the millions. It is not surprising, then, that the need for rapid and precise tests, conducted economically by trained professionals, has become a major goal. Current government approved and peer reviewed laboratory methods for urine analysis serve present needs very well and have become remarkably robust over the past twenty years, but the logistics of testing some moving populations, such as the military, the Coast Guard, workers on off-shore oil platforms, and athletes—perhaps the most mobile of these groups—are unacceptably cumbersome.

Forensic Toxicology

Forensic Toxicology Book
Author : Nicholas T Lappas,Courtney M Lappas
Publisher : Academic Press
Release : 2015-11-14
ISBN : 0128004649
Language : En, Es, Fr & De

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Book Description :

Forensic Toxicology: Principles and Concepts takes the reader back to the origins of forensic toxicology providing an overview of the largely unchanging principles of the discipline. The text focuses on the major tenets in forensic toxicology, including an introduction to the discipline, fundamentals of forensic toxicology analysis, types of interpretations based on analytical forensic toxicology results, and reporting from the laboratory to the courtroom. Forensic Toxicology also contains appendices covering the principles of pharmacokinetics and pharmacodynamics, immunology and immunological assays, toxicogenomics, and case studies. Significant emphasis on the fundamental principles and concepts of forensic toxicology Provides students with an introduction to the core tenets of the discipline, focusing on the concepts, strategies, and methodologies utilized by professionals in the field Coauthored by a forensic toxicologist with over 40 years of experience as a professor who has taught graduate courses in forensic and analytical toxicology and who has served as a consultant and expert witness in civil and criminal cases The book's companion website, http://textbooks.elsevier.com/web/Manuals.aspx?isbn=9780127999678 features exclusive web-based content

Forensic Science

Forensic Science Book
Author : Anonim
Publisher : Elsevier
Release : 2011-09-22
ISBN : 9780080554259
Language : En, Es, Fr & De

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Book Description :

The book presents the applications of separation methods, manly chromatography, in forensic practice. The first part, devoted to forensic toxicology, contains reviews on forensic relevant groups of compounds, like: Opiate agonists, cocaine, amphetamines, hallucinogens, cannabinoids, sedatives and hypnotics, antidepressive and antipsychotic drugs, analgesics, antidiabetics, muscle relaxants, and mushroom toxins. In these parts, the preliminary immunochemical tests were also included, together with separation methods. Screening procedures used in forensic toxicology were presented in separate chapters on forensic screening with GC, GC-MS, HPLC, LC-MS, CE, and LC-ICP-MS. In the part on actual and emerging problems of forensic toxicology, following chapters were included: Analytical markers of alcohol abuse, toxicological aspects of herbal remedies, drugs and driving, analysis in alternative matrices, doping analysis, pharmacogenomics in forensic toxicology, and quality assurance. The second part presents application of separation methods in forensic chemistry, and comprises chapters on: Explosives, chemical warfare agents, arson analysis, and writing media. Third part on forensic identification contains chapter on forensic genetics. All chapters are written up-to-date and present specific information up to 2006. The authors of each chapter are known not only from their scientific activity, but are also reputed experts, proven in everyday forensic casework. - Wide spectrum of topics presented - Up-to-date presentation of topics - Data are presented in comparative mode - Special stress put on screening procedures

Herbicides

Herbicides Book
Author : Anonim
Publisher : Elsevier
Release : 2021-06-25
ISBN : 0128236752
Language : En, Es, Fr & De

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Book Description :

Herbicides: Chemistry, Efficacy, Toxicology, and Environmental Impacts addresses contemporary debates on herbicide toxicology. The reader is offered a comprehensive overview of this complex topic, presented by internationally recognized experts. Information presented will inform discussions on the use of herbicides in modern agricultural and other systems, and their potential non-target effects on human populations and various ecosystems. The book covers these matters in concise language appropriate to engage both specialists in the research community and informed persons responsible for legislative, funding, and public health matters in the community at large. The use of herbicides is an essential pillar of modern agricultural production systems. Weeds, if uncontrolled, would reduce crop yield and result in massive economic damage. Recently, the heavy reliance on single herbicides has been linked to the development of weed resistance. To combat resistant weeds, farmers are advised to use a mix of several herbicides and to increase herbicide application rates. As a result, the toxicity of herbicides on human health and the environment has become a controversial topic. Offers a comprehensive overview of herbicide science in modern agricultural systems Addresses the complex problems that can arise from herbicide use and misuse, including weed resistance, pollution, and human health issues Uses recent examples to demonstrate the topical nature of this issue

Particulates Matter

Particulates Matter Book
Author : Vikram Rao,William Vizuete
Publisher : Elsevier
Release : 2020-11-28
ISBN : 0128169052
Language : En, Es, Fr & De

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Book Description :

A title in the Emerging Issues in Analytical Chemistry series, Particulates Matter: Impact, Measurement, and Remediation of Airborne Pollutants provides the latest technical findings in the study of particulate matter (PM). It links these findings to awareness-raising and actionable schemes for legislated remediation and engineered solutions. Written in an engaging and informative manner, the book begins with a multi-disciplinary overview of the major sources and unique classes of PM, detection techniques, and their impact, including molecular changes resulting in health effects. It then goes one step further by proposing and examining the means to curtail and contain PM generation and ameliorate their impacts. Particulates Matter: Impact, Measurement, and Remediation of Airborne Pollutants offers a high-quality reference guide to PM that will greatly benefit technology leaders in environmental compliance groups, epidemiologists and other public health professionals focused on pollution and health, and researchers and scholars working in pollution, climate change, and urbanization. It may also be useful to advanced undergraduate and early graduate students in environmental sciences. Includes a summary of the current knowledge on nanoparticles as pollutants and their negative health effects Provides a framework for the evolution and maturation of air pollution characterization and mitigation Describes an integrated set of engineered solutions that account for the concatenated relationships between technology, policy, and society necessary for long-term success

Analytical Methods for Biomass Characterization and Conversion

Analytical Methods for Biomass Characterization and Conversion Book
Author : David C. Dayton,Thomas D. Foust
Publisher : Elsevier
Release : 2019-11-05
ISBN : 0128156066
Language : En, Es, Fr & De

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Book Description :

Analytical Methods for Biomass Characterization and Conversion is a thorough resource for researchers, students and professors who investigate the use of biomass for fuels, chemicals and products. Advanced analytical chemistry methods and techniques can now provide detailed compositional and chemical measurements of biomass, biomass conversion process streams, intermediates and products. This volume from the Emerging Issues in Analytical Chemistry series brings together the current knowledge on each of these methods, including spectroscopic methods (Fourier Transform Infrared Spectroscopy, Near-infrared Spectroscopy, Solid State Nuclear Magnetic Resonance), pyrolysis (Gas Chromatography/Mass Spectrometry), Liquid Chromatography/High Performance Liquid Chromatography, Liquid Chromatography/Mass Spectrometry, and so on. Authors David C. Dayton and Thomas D. Foust show how these can be used for measuring biomass composition and for determining the composition of intermediates with regard to subsequent processing for biofuels, bio-chemicals and bio-based products. Covers the broad range of techniques and applications that have been developed and perfected in the last decade Highlights specific analyses required for understanding biomass conversion to select intermediates Provides references to seminal books, review articles and technical articles that go into greater depth, serving as a basis for further study

Mass Spectrometry for the Analysis of Pesticide Residues and Their Metabolites

Mass Spectrometry for the Analysis of Pesticide Residues and Their Metabolites Book
Author : Despina Tsipi,Helen Botitsi,Anastasios Economou
Publisher : John Wiley & Sons
Release : 2015-04-27
ISBN : 1118500172
Language : En, Es, Fr & De

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Book Description :

Provides an overview of the use of mass spectrometry (MS) for the analysis of pesticide residues and their metabolites. Presents state of the-art MS techniques for the identification of pesticides and their transformation products in food and environment Covers important advances in MS techniques including MS instrumentation and chromatographic separations (e.g. UPLC, HILIC, comprehensive GCxGC) and applications Illustrates the main sample preparation techniques (SPE, QuEChERS, microextraction) used in combination with MS for the analysis of pesticides Describes various established and new ionization techniques as well as the main MS platforms, software tools and mass spectral libraries

Technology in Forensic Science

Technology in Forensic Science Book
Author : Deepak Rawtani,Chaudhery Mustansar Hussain
Publisher : John Wiley & Sons
Release : 2020-11-02
ISBN : 3527347623
Language : En, Es, Fr & De

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Book Description :

The book "Technology in Forensic Science" provides an integrated approach by reviewing the usage of modern forensic tools as well as the methods for interpretation of the results. Starting with best practices on sample taking, the book then reviews analytical methods such as high-resolution microscopy and chromatography, biometric approaches, and advanced sensor technology as well as emerging technologies such as nanotechnology and taggant technology. It concludes with an outlook to emerging methods such as AI-based approaches to forensic investigations.