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Designing And Conducting Translational Research Gastroenterology

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Journal of the National Cancer Institute

Journal of the National Cancer Institute Book
Author : Anonim
Publisher : Unknown
Release : 1999-11
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download Journal of the National Cancer Institute book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Evidence based Gastroenterology and Hepatology

Evidence based Gastroenterology and Hepatology Book
Author : John W. D. McDonald,Brian G. Feagan,Rajiv Jalan,Peter J. Kahrilas
Publisher : John Wiley & Sons
Release : 2019-04-29
ISBN : 1119211387
Language : En, Es, Fr & De

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Book Description :

The revised fourth edition of Evidence-Based Gastroenterology and Hepatology continues to provide the most current, evidence-based information for determining the appropriate medical and surgical options for screening for, diagnosing, and treating gastrointestinal conditions. With contributions from an international team of leading experts in the field, the 4th edition includes practical recommendations for the care of individual patients based on the latest scientific evidence.

Translational Research and Discovery in Gastroenterology

Translational Research and Discovery in Gastroenterology Book
Author : Deborah L. Gumucio,Linda C. Samuelson,Jason R. Spence
Publisher : John Wiley & Sons
Release : 2014-08-11
ISBN : 1118492870
Language : En, Es, Fr & De

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Book Description :

Translational Gastroenterology: Organogenesis to Disease bridges the gap between basic and clinical research by providing information on GI (gastrointestinal) organ development discovered through scientific inquiry, alongside clinical observations of acquired and congenital abnormalities. Paired chapters, written from basic science and clinical viewpoints, review the major biological pathways and molecules at work in organ ontogeny and disease. In addition to a comprehensive survey of GI organ development and pathologies, the book also highlights model organisms and new areas of research, with chapters devoted to recent advances in the field of GI stem cell biology, and the potential for tissue engineering of GI organs. The topics covered provide a unique window onto current activity in the field of gastroenterology, fostering enhanced knowledge for developmental biologists as well as for clinical practitioners. Notable features include the following: • Basic science chapters review the molecular and cellular pathways of GI organ development alongside clinical chapters examining organ-based diseases, closing the gap between the bench and the clinic. • Derivative organs – esophagus, stomach, pylorus, small intestine, colon, liver, and pancreas –as well as tissues such as serosa and enteric nervous system that are common to multiple GI organs. • Chapters detailing the use of model organisms – Drosophila, sea urchin, zebrafish, C. elegans, Xenopus – for basic discovery studies are included. • Chapters on GI stem cells and the potential for tissue engineering of the GI organs provide a view to the future of research and therapy in these organs.

Global Clinical Trials Playbook

Global Clinical Trials Playbook Book
Author : Menghis Bairu,Richard Chin
Publisher : Academic Press
Release : 2012
ISBN : 0124157874
Language : En, Es, Fr & De

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Book Description :

Pharmaceuticals companies, biotech companies, and CROs, regardless of size, all face the same challenge of managing costs and operational execution associated with bringing a valuable drugs and devices to market. Because of timeline pressures and cost as well as the growing interest in "neglected diseases" and diseases affecting the emerging nations, clinical trials are increasingly conducted in emerging markets and developing countries where infrastructure, leadership, skilled personnel and a governance are at a premium. Working with academics, regulatory professionals, safety officers, experts from the pharma industry and CROs, the editors have put together this up-to-date, step-by-step guide book to building and enhancing global clinical trial capacity in emerging markets and developing countries. This book covers the design, conduct, and tools to build and/or enhance human capacity to execute such trials, appealing to individuals in health ministries, pharmaceutical companies, world health organizations, academia, industry, and non-governmental organizations (NGOs) who are managing global clinical trials. * Gives medical professionals the business tools needed to effectively execute clinical trials throughout the world * Provides real world international examples which illustrate the practical translation of principles * Includes forms, templates, and additional references for standardization in a number of global scenarios

Prostate Cancer

Prostate Cancer Book
Author : Anonim
Publisher : Unknown
Release : 2022-08-10
ISBN : 1783261196
Language : En, Es, Fr & De

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Download Prostate Cancer book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Malaysia Bengali Doctors 1907 2012 a Personal Perspective

Malaysia   Bengali Doctors 1907 2012 a Personal Perspective Book
Author : Dr. P. R. Sengupta
Publisher : Xlibris Corporation
Release : 2013-03-23
ISBN : 1479757675
Language : En, Es, Fr & De

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Book Description :

The past century has been an exciting era for the Bengalis in Malaysia attempting to preserve our identity and cultural heritage. However with the dilution of the community the radar for the coming years is misty. In the course of our efforts to uphold our identity and provide services to the public and be counted, we have not lost sight of our primary professional responsibility as doctors. Many have contributed towards the advancement of the profession by actively participating in research as well as providing financial grants. It is an opportune time to write this book. Our identity might be totally lost in the next 100 years except for the imposing edifice of Bengal House in Port Dickson, Negri Sembilan to bear testimony to the once thriving, vibrant proud Bengali community. The publication would be collecting dust and cobwebs and would be useful only to historians possibly excavating into our possible extinct past. Since commencing this book, two very prominent senior members have passed away, and it is most unfortunate that they have not seen this humble effort. We live in a global world transcending geographical boundaries and preservation of the last vestiges of our heritage should be the responsibility of each and every one of us. The objectives of undertaking this Herculean task which hopefully have been fulfilled were an attempt to: Compile a list of Bengali doctors since their first arrival more than 100 years ago in what was then Malaya together with the subsequent 2nd & 3rd generation doctors born here. Some names might have been left out inadvertently for which sincere apologies are extended while a handful had not responded to repeated efforts to contact them or their next of kin. Explore the reasons for their migration. Many who were from the same district of East Bengal as Rai Bahadur Dr Sarojininath Bardhans and were related to him through his marriages were probably influenced by his success. Some arrived to avoid political persecutions. Global conditions such as World Wars I &II and the Great Depression of the 1930s obviously played an important part in the decision making process. The Post World War II years witnessed the return of local doctors whose studies were interrupted and a couple had harrowing experiences to narrate. Some contract doctors were also recruited directly by private local clinics. Highlight the decades of the 50&60s which could be rightly considered as the golden era for the Bengali doctors. There were insufficient numbers of local graduates to fill the posts as most of the Chinese doctors went into the vast lucrative private sector while very few Malays had taken up Medicine. Although a large number had applied from Bengal, only about 35-40 doctors including a few with post graduate qualifications were recruited. Some climbed up the ranks and became senior administrative officers, appointed not on the basis of availability but because of their capability and proven track records. In the1960s, the Medical Faculty of University of Malaya was established in Kuala Lumpur and some Calcutta graduates with post graduate qualifications from the United Kingdom were offered key posts to help jump start certain disciplines. This was an excellent testimony of the academic standards of Calcutta University graduates. These two decades also witnessed the successes of the 2nd generation Bengalis with a couple completing their post graduate medical studies in double-quick time. The first Malaysian Radiologist to start Angiographic studies and to be awarded a neuro-vascular fellowship in Sweden in 1968/69 was a Bengali. In view of the limited number of super scale posts, many however were given glorified titles of State Physicians or Surgeons despite being only Clinical Specialists! Reiterate the contributions of Bengali doctors towards the Malayanisation of the medical and health services in the two states of Sabah & Sarawak in early 1970s. The efforts of Dr. Rabindranath Roy in unifying

Contested Cells Global Perspectives On The Stem Cell Debate

Contested Cells  Global Perspectives On The Stem Cell Debate Book
Author : Benjamin J Capps,Alastair V Campbell
Publisher : World Scientific
Release : 2010-08-19
ISBN : 1908978295
Language : En, Es, Fr & De

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Book Description :

This book represents the coming together of a number of internationally renowned scholars from science, philosophy, law and social science. Each author presents a distinctive and critical account of the current ethical, social and jurisprudential issues concerning stem cell science: together covering both its research beginnings, and the future translation into the clinical setting. Original to this volume is an emphasis on the inter-state implications of developments in stem cell science from the perspective of a truly global collaboration of leading authors. Academics and policy-makers will find it an invaluable contribution to the socio-political and ethical discourse of stem cell science./a

Translational Side of Emerging Invasive and Non Invasive Stimulation Therapies

Translational Side of Emerging Invasive and Non Invasive Stimulation Therapies Book
Author : Jiande Chen,Bruno Bonaz,Leo Cheng,Luming Li
Publisher : Frontiers Media SA
Release : 2022-02-25
ISBN : 288974535X
Language : En, Es, Fr & De

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Book Description :

Download Translational Side of Emerging Invasive and Non Invasive Stimulation Therapies book written by Jiande Chen,Bruno Bonaz,Leo Cheng,Luming Li, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Future of the U S Department of Veterans Affairs Healthcare in South Louisiana

The Future of the U S  Department of Veterans Affairs Healthcare in South Louisiana Book
Author : United States. Congress. House. Committee on Veterans' Affairs
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Future of the U S Department of Veterans Affairs Healthcare in South Louisiana book written by United States. Congress. House. Committee on Veterans' Affairs, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Resistance to Molecular Therapies for Hepatocellular Carcinoma

Resistance to Molecular Therapies for Hepatocellular Carcinoma Book
Author : Augusto Villanueva
Publisher : Springer
Release : 2017-07-14
ISBN : 3319561979
Language : En, Es, Fr & De

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Book Description :

This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies.

Smith s Anesthesia for Infants and Children E Book

Smith s Anesthesia for Infants and Children E Book Book
Author : Peter J. Davis,Franklyn P. Cladis
Publisher : Elsevier Health Sciences
Release : 2021-11-30
ISBN : 0323698263
Language : En, Es, Fr & De

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Book Description :

Written and edited by renowned experts in pediatric anesthesia, Smith's Anesthesia for Infants and Children provides clear, concise guidance on effective perioperative care for any type of pediatric surgery. The 10th Edition contains significantly revised content throughout, bringing you fully up to date with recent advances in clinical and basic science that have led to changes in today’s clinical practice. Offers comprehensive coverage of physiology, pharmacology, and clinical anesthetic management of infants and children of all ages. Contains new chapters on Airway Physiology and Development, Normal and Difficult Airway Management, Ultrasound, Acute Pain Management, Chronic Pain Management, Palliative Pain Management, Infectious Diseases, and Education; plus extensively revised content on cardiovascular physiology; induction, maintenance, and recovery; organ transplantation, and more. Features more than 100 video demonstrations, including regional anesthesia videos, echocardiograms of congenital heart lesions, anatomic dissections of various congenital heart specimens with audio explanations, various pediatric surgical operative procedures, airway management, and much more. Provides outstanding visual guidance throughout, including full-color photographs, drawings, graphs and charts, and radiographic images. Includes quick-reference appendices online: drug dosages, growth curves, normal values for pulmonary function tests, and a listing of common and uncommon syndromes. Provides an interactive question bank online for review and self-assessment.

Drug Induced Liver Injury

Drug Induced Liver Injury Book
Author : Anonim
Publisher : Academic Press
Release : 2019-07-13
ISBN : 0128173173
Language : En, Es, Fr & De

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Book Description :

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2013

Departments of Labor  Health and Human Services  Education  and Related Agencies Appropriations for 2013 Book
Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2013 book written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Inflammatory Immune Disease Molecular Mechanisms Translational Approaches and Therapeutics

Inflammatory Immune Disease  Molecular Mechanisms  Translational Approaches and Therapeutics Book
Author : Tao Xu,Jian Gao,Sung Hwan Ki,Emanuela Ricciotti
Publisher : Frontiers Media SA
Release : 2022-07-05
ISBN : 2889747956
Language : En, Es, Fr & De

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Book Description :

Download Inflammatory Immune Disease Molecular Mechanisms Translational Approaches and Therapeutics book written by Tao Xu,Jian Gao,Sung Hwan Ki,Emanuela Ricciotti, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Stem Cell Dependent Therapies

Stem Cell Dependent Therapies Book
Author : Gerhard Gross,Thomas Häupl
Publisher : Walter de Gruyter
Release : 2013-10-29
ISBN : 3110298309
Language : En, Es, Fr & De

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Book Description :

Multipotent mesenchymal stem cells (MSCs) are a heterogeneous population of cells which reside in a variety of tissues. They differentiate into several mesodermal lineages, secrete a multitude of trophic factors and contribute to tissue homeostasis. MSCs are able to exert immunosuppressive activities by interfering with inflammatory cytokine production and with T- and B-cell proliferation. These immunomodulating properties make MSCs promising candidates for the treatment of chronic inflammatory and autoimmune disorders. There are, however, certain caveats involved including inappropriate migration of cells in the body, immune rejection, tumor formation, or graft versus host disease (GvHD). This book investigates the current state of the MSC-dependent therapy of chronic inflammatory disorders and autoimmune diseases. Among the covered topics are GvHD, chronic kidney, liver and lung disease, ischemic heart and inflammatory bowel disease, diabetes, osteoarthritis, various rheumatic and neurological disorders and, lastly, tumors and solid organ transplantations. This book also questions the immunoprivileged status of MSCs, discusses the therapeutic role of MSCs in experimental animal disease models and their translation to the corresponding human disorders, envisions a role for MSCs in tumor interventions and, lastly, describes a systems biology approach for stem cells and inflammation.

Translational Research Methods in Diabetes Obesity and Nonalcoholic Fatty Liver Disease

Translational Research Methods in Diabetes  Obesity  and Nonalcoholic Fatty Liver Disease Book
Author : Andrew J. Krentz,Christian Weyer,Marcus Hompesch
Publisher : Springer
Release : 2019-04-02
ISBN : 3030117480
Language : En, Es, Fr & De

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Book Description :

This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders. Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs. This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Evaluating and Conducting Research in Audiology

Evaluating and Conducting Research in Audiology Book
Author : Vinaya Manchaiah, Eldré Beukes, Ross J. Roeser
Publisher : Plural Publishing
Release : 2021-02-04
ISBN : 1635502012
Language : En, Es, Fr & De

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Book Description :

Evaluating and Conducting Research in Audiology is the first research methods textbook that is specific to the field of audiology and designed to serve as an academic textbook for audiology graduate students. This text can also be accessible for audiology practitioners who are interested in clinical and applied research. The comprehensive coverage includes materials for multiple courses within audiology degree programs, including research methods, analysis of professional literature, evidence-based practice, and capstone research projects. Classroom tested, and written by authors who have extensive backgrounds in publishing and editing, this text provides knowledge that is required in evaluating, conducting, and disseminating research. The book is separated into three sections: (a) research methods; (b) evidence-based practice; and (c) conducting and disseminating research. Together, these sections provide a detailed coverage of the research methods that are relevant to conducting research, particularly in the field of Audiology. Key Features: * Learning outcomes at the beginning of each chapter * End of chapter reviews including key points and study questions * Audiology-specific examples, research methods, and study designs * “Golden Nugget” boxes throughout the book containing valuable information related to the critical concepts * In-depth discussion of qualitative research methods, survey research methods, and systematic reviews to motivate students and early career researchers to consider these methodologies in their research

Pediatric Obesity From the Spectrum of Clinical Physiology Social Psychology and Translational Research

Pediatric Obesity  From the Spectrum of Clinical Physiology  Social Psychology  and Translational Research Book
Author : Ching-Feng Cheng,Yen-Hsuan Ni
Publisher : Frontiers Media SA
Release : 2021-11-23
ISBN : 2889716562
Language : En, Es, Fr & De

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Book Description :

Download Pediatric Obesity From the Spectrum of Clinical Physiology Social Psychology and Translational Research book written by Ching-Feng Cheng,Yen-Hsuan Ni, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Microbiota in Gastrointestinal Pathophysiology

The Microbiota in Gastrointestinal Pathophysiology Book
Author : Martin H. Floch,Yehuda Ringel,W. Allen Walker
Publisher : Academic Press
Release : 2016-12-16
ISBN : 9780128040249
Language : En, Es, Fr & De

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Book Description :

The Microbiota in Gastrointestinal Pathophysiology: Implications for Human Health, Prebiotics, Probiotics and Dysbiosis is a one-stop reference on the state of the art research on gut microbial ecology in relation to human disease. This important resource starts with an overview of the normal microbiota of the gastrointestinal tract including the esophagus, stomach, Ileum and colon. It goes on to identify what a healthy vs. unhealthy microbial community looks like including methods of identification. Also included is insight into which features and contributions the microbiota make that are essential and useful to host physiology. Also included is information on how to promote appropriate mutualisms and prevent undesirable dysbioses. Through the power of synthesizing what is known by experienced researchers in the field, current gaps are closed, raising understanding of the role of the microbiome and allowing for further research. Explains how to modify the gut microbiota and how the current strategies used to do this produce their effects Explores the gut microbiota as a therapeutic target Provides the synthesis of existing data from both mainstream and non-mainstream sources through experienced researchers in the field Serves as a 'one-stop' shop for a topic that's currently spread across a number of various journals

Modern Management of Benign and Malignant Pancreatic Disease An Issue of Gastroenterology Clinics E Book

Modern Management of Benign and Malignant Pancreatic Disease  An Issue of Gastroenterology Clinics   E Book Book
Author : Jacques Van Dam
Publisher : Elsevier Health Sciences
Release : 2012-03-26
ISBN : 1455742805
Language : En, Es, Fr & De

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Book Description :

Dr. Van Dam is an internationally recognized leader in gastroenterology and has been a leader in advances in intervedntional endoscopy. He brings this expertise to the topic of management of benign and malignant pancreatic disease and has selected top experts in the field to provide state-of-the-art clinical information to gastroenterologists. The modern management treatise of each article addresses current diagnostics as well as medical management. Seven articles are devoted to pancreatic cancer and span medical management, surgial mangament, radiologic imaging, endoscopic diagnosis, palliation, and screening. Other important topics addressed are pancreatic transplantation, pancreatic cystic neoplasms, acute and chronic pancreatitis, and autoimmune pancreatitis.