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Design And Development Of New Nanocarriers

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Design and Development of New Nanocarriers

Design and Development of New Nanocarriers Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2017-12-12
ISBN : 0128136286
Language : En, Es, Fr & De

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Book Description :

Design and Development of New Nanocarriers focuses on the design and development of new nanocarriers used in pharmaceutical applications that have emerged in recent years. In particular, the pharmaceutical uses of microfluidic techniques, supramolecular design of nanocapsules, smart hydrogels, polymeric micelles, exosomes and metal nanoparticles are discussed in detail. Written by a diverse group of international researchers, this book is a valuable reference resource for those working in both biomaterials science and the pharmaceutical industry. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

Medicinal Chemistry with Pharmaceutical Product Development

Medicinal Chemistry with Pharmaceutical Product Development Book
Author : Debarshi Kar Mahapatra,Sanjay Kumar Bharti
Publisher : CRC Press
Release : 2019-02-04
ISBN : 0429947151
Language : En, Es, Fr & De

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Book Description :

This volume focuses on novel therapeutics and strategies for the development of pharmaceutical products, keeping the drug molecule as the central component. It discusses current theoretical and practical aspects of pharmaceuticals for the discovery and development of novel therapeutics for health problems. Explaining the necessary features essential for pharmacological activity, it takes an interdisciplinary approach by including a unique combination of pharmacy, chemistry, and medicine along with clinical aspects. It takes into consideration the therapeutic regulations of the USP along with all the latest therapeutic guidelines put forward by WHO, and the US Food and Drug Administration.

Intracellular Delivery III

Intracellular Delivery III Book
Author : Aleš Prokop,Volkmar Weissig
Publisher : Springer
Release : 2016-10-31
ISBN : 3319435256
Language : En, Es, Fr & De

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Book Description :

A critical review is attempted to assess the status of nanomedicine entry onto the market. The emergence of new potential therapeutic entities such as DNA and RNA fragments requires that these new “drugs” will need to be delivered in a cell-and organelle-specific manner. Although efforts have been made over the last 50 years or so to develop such delivery technology, no effective and above all clinically approved protocol for cell-specific drug delivery in humans exists as yet. Various particles, macromolecules, liposomes and most recently “nanomaterials” have been said to “show promise” but none of these promises have so far been “reduced” to human clinical practice. The focus of this volume is on cancer indication since the majority of published research relates to this application; within that, we focus on solid tumors (solid malignancies). Our aim is critically to evaluate whether nanomaterials, both non-targeted and targeted to specific cells, could be of therapeutic benefit in clinical practice. The emphasis of this volume will be on pharmacokinetics (PK) and pharmacodynamics (PD) in animal and human studies. Apart from the case of exquisitely specific antibody-based drugs, the development of target-specific drug–carrier delivery systems has not yet been broadly successful at the clinical level. It can be argued that drugs generated using the conventional means of drug development (i.e., relying on facile biodistribution and activity after (preferably) oral administration) are not suitable for a target-specific delivery and would not benefit from such delivery even when a seemingly perfect delivery system is available. Therefore, successful development of site-selective drug delivery systems will need to include not only the development of suitable carriers, but also the development of drug entities that meet the required PK/PD profile.

Nanostructures for the Engineering of Cells Tissues and Organs

Nanostructures for the Engineering of Cells  Tissues and Organs Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-02-14
ISBN : 0128136669
Language : En, Es, Fr & De

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Book Description :

Nanostructures for the Engineering of Cells: Tissues and Organs showcases recent advances in pharmaceutical nanotechnology, with particular emphasis on tissue engineering, organ and cell applications. The book provides an up-to-date overview of organ targeting and cell targeting using nanotechnology. In addition, tissue engineering applications, such as skin regeneration are also discussed. Written by a diverse range of international academics, this book is a valuable research resource for researchers working in the biomaterials, medical and pharmaceutical industries. Explains how nanomaterials regulate different cell behavior and function as a carrier for different biomolecules Shows how nanobiomaterials and nanobiodevices are used in a range of treatment areas, such as skin tissue, wound healing and bone regeneration Discusses nanomaterial preparation strategies for pharmaceutical application and regenerative medicine

Fullerens Graphenes and Nanotubes

Fullerens  Graphenes and Nanotubes Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-05-28
ISBN : 0128136928
Language : En, Es, Fr & De

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Book Description :

Fullerens, Graphenes and Nanotubes: A Pharmaceutical Approach shows how carbon nanomaterials are used in the pharmaceutical industry. While there are various books on the carbonaceous nanomaterials available on the market, none approach the subject from a pharmaceutical point-of-view. In this context, the book covers different applications of carbonaceous nanomaterials. Chapters examine different types of carbon nanomaterials and explore how they are used in such areas as cancer treatments, pulse sensing and prosthetics. Readers will find this book to be a valuable reference resource for those working in the areas of carbon materials, nanomaterials and pharmaceutical science. Explains how the unique properties of carbon-based nanomaterials allow them to be used to create effective drug delivery systems Covers how carbon-based nanomaterials should be prepared for use in pharmaceutical applications Discusses the relative toxicity of a range of carbon-based nanomaterials Considers the safety of their use in different types of drugs

Drug Targeting and Stimuli Sensitive Drug Delivery Systems

Drug Targeting and Stimuli Sensitive Drug Delivery Systems Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-05-21
ISBN : 0128136901
Language : En, Es, Fr & De

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Book Description :

Drug Targeting and Stimuli Sensitive Drug Delivery Systems covers recent advances in the area of stimuli sensitive drug delivery systems, providing an up-to-date overview of the physical, chemical, biological and multistimuli-responsive nanosystems. In addition, the book presents an analysis of clinical status for different types of nanoplatforms. Written by an internationally diverse group of researchers, it is an important reference resource for both biomaterials scientists and those working in the pharmaceutical industry who are looking to help create more effective drug delivery systems. Shows how the use of nanomaterials can help target a drug to specific tissues and cells Explores the development of stimuli-responsive drug delivery systems Includes case studies to showcase how stimuli responsive nanosystems are used in a variety of therapies, including camptothecin delivery, diabetes and cancer therapy

Inorganic Frameworks as Smart Nanomedicines

Inorganic Frameworks as Smart Nanomedicines Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-04-09
ISBN : 0128136626
Language : En, Es, Fr & De

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Book Description :

Inorganic Frameworks as Smart Nanocarriers for Drug Delivery brings together recent research in the area of inorganic frameworks for drug delivery. Different types of nanocarriers are presented and discussed in detail, providing an up-to-date overview on inorganic nanoparticles with pharmaceutical applications. Written by a diverse range of international academics, this book is a valuable reference resource for researchers in biomaterials, the pharmaceutical industry, and those who want to learn more about the current applications of inorganic smart nanocarriers. Includes assembly methods for a variety of smart nanocarrier systems, also showing how they are applied Highlights how metal-oxide nanoparticles are effectively used in drug delivery Assesses the pros and cons of different metallic nanomaterials as drug carriers

Nanoscale Fabrication Optimization Scale up and Biological Aspects of Pharmaceutical Nanotechnology

Nanoscale Fabrication  Optimization  Scale up and Biological Aspects of Pharmaceutical Nanotechnology Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2017-12-11
ISBN : 0128136308
Language : En, Es, Fr & De

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Book Description :

Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology focuses on the fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology. In particular, the following aspects of nanoparticle preparation methods are discussed: the need for less toxic reagents, simplification of the procedure to allow economic scale-up, and optimization to improve yield and entrapment efficiency. Written by a diverse range of international researchers, the chapters examine characterization and manufacturing of nanomaterials for pharmaceutical applications. Regulatory and policy aspects are also discussed. This book is a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about how nanomaterials can best be utilized. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

Design and Development of Novel Nanocarriers for Targeted Drug Delivery

Design and Development of Novel Nanocarriers for Targeted Drug Delivery Book
Author : Mhd Anas Tomeh
Publisher : Unknown
Release : 2021
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Design and Development of Novel Nanocarriers for Targeted Drug Delivery book written by Mhd Anas Tomeh, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug Delivery Using Nanomaterials

Drug Delivery Using Nanomaterials Book
Author : Yasser Shahzad,Syed A.A. Rizvi,Abid Mehmood Yousaf,Talib Hussain
Publisher : CRC Press
Release : 2022-01-19
ISBN : 1000529495
Language : En, Es, Fr & De

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Book Description :

After the drug discovery and development process, designing suitable formulations to safely deliver the optimum dose, while avoiding side effects, has been a constant challenge, especially when drugs are very toxic and have poor solubility and undesirable clearance profiles. With recent advances in synthetic technologies, nanoparticles can be custom-made from a variety of advanced materials to mimic the bioenvironment and can be equipped with various targeting and imaging moieties for site-specific delivery and real-time imaging. Drug Delivery Using Nanomaterials covers advancements in the field of nanoparticle-based drug-delivery systems, along with all the aspects needed for a successful and marketable nanoformulation. FEATURES Offers a general overview of the entire process involved in the synthesis and characterization of pharmaceutical nanoparticles Covers a broad range of synthetic materials for developing nanoformulations customized for specific disease states, target organs, and drugs Every chapter sequentially builds, providing a progressive pathway from classical nanoparticles to the more advanced to be used as a full drug product by consumers Provides information in a bottom-up manner in that definitions and explanations of relevant background information serve as a framework for understanding advanced concepts This user-friendly reference is aimed at materials engineers, chemical engineers, biomedical engineers, pharmaceutical scientists, chemists, and others working on advanced drug delivery, from academia as well as industry.

Advances in Pharmaceutical Biotechnology

Advances in Pharmaceutical Biotechnology Book
Author : Jayanta Kumar Patra,Amritesh C. Shukla,Gitishree Das
Publisher : Springer Nature
Release : 2020-03-30
ISBN : 9811521956
Language : En, Es, Fr & De

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Book Description :

This book explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical uses. The foundations of pharmaceutical biotechnology lie mainly in the capability of plants, microorganism, and animals to produce low and high molecular weight compounds useful as therapeutics. Pharmaceutical biotechnology has flourished since the advent of recombinant DNA technology and metabolic engineering, supported by the well-developed bioprocess technology. A large number of monoclonal antibodies and therapeutic proteins have been approved, delivering meaningful contributions to patients’ lives, and the techniques of biotechnology are also a driving force in modern drug discovery. Due to this rapid growth in the importance of biopharmaceuticals and the techniques of biotechnologies to modern medicine and the life sciences, the field of pharmaceutical biotechnology has become an increasingly important component in the education of pharmacists and pharmaceutical scientists. This book will serve as a complete one-stop source on the subject for undergraduate and graduate pharmacists, pharmaceutical science students, and pharmaceutical scientists in industry and academia.

Advances in Sustainable Polymers

Advances in Sustainable Polymers Book
Author : Vimal Katiyar,Amit Kumar,Neha Mulchandani
Publisher : Springer Nature
Release : 2020-03-03
ISBN : 9811512515
Language : En, Es, Fr & De

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Book Description :

This book discusses synthesis and characterization of sustainable polymers. The book covers opportunities and challenges of using sustainable polymers to replace existing petroleum based feedstock. This volume provides insights into the chemistry of polymerization, and discusses tailoring the properties of the polymers at the source in order fit requirements of specific applications. The book also covers processing of these polymers and their critical assessment. The book will be of use to chemists and engineers in the industry and academia working on sustainable polymers and their commercialization to replace dependence on petroleum-based polymers.

Nano Hydrogels

Nano Hydrogels Book
Author : Jiya Jose,Sabu Thomas,Vijay Kumar Thakur
Publisher : Springer Nature
Release : 2021
ISBN : 9811571384
Language : En, Es, Fr & De

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Book Description :

This book introduces the reader to important aspects of the nano-hydrogels. It covers the development of hydrogels and their biology, chemistry and properties. Focus is also given to innovative characterization techniques and advances in structural design, with special emphasis on molecular structure, dynamic behavior and structural modifications of hydrogels. This book serves as a consolidated reference work for the diverse aspects of hydrogels, creating a valuable resource for students and researchers in academia and industry. .

Self Assembly of Nano and Micro structured Materials Using Colloidal Engineering

Self Assembly of Nano  and Micro structured Materials Using Colloidal Engineering Book
Author : Dwaipayan Chakrabarti,Stefano Sacanna
Publisher : Elsevier
Release : 2019-04-25
ISBN : 0081023030
Language : En, Es, Fr & De

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Book Description :

Self-assembly of Nano- and Micro-structured Materials Using Colloidal Engineering, Volume 12, covers the recent breakthroughs in the design and manufacture of functional colloids at the micro- and nanoscale level. In addition, it provides analyses on how these functionalities can be exploited to develop self-assembly pathways towards nano- and micro-structured materials. As we seek increasingly complex functions for colloidal superstructures, in silico design will play a critical role in guiding experimental fabrication by reducing the element of trial-and-error that would otherwise be involved. In addition to novel experimental approaches, recent developments in computational modelling are also presented, along with an overview of the arsenal of designing tools that are available to the modern materials scientist. Focuses on promoting feedback between experiment, theory and computation in this cross-disciplinary research area Shows how colloid science plays a crucial role in the bottom-up fabrication of nanostructured materials Presents recent developments in computational modelling

Surface Chemistry of Colloidal Nanocrystals

Surface Chemistry of Colloidal Nanocrystals Book
Author : Ana Luísa Daniel-da-Silva,Tito Trindade
Publisher : Royal Society of Chemistry
Release : 2021-02-08
ISBN : 1788019814
Language : En, Es, Fr & De

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Book Description :

The chemistry of nanomaterials has developed considerably in the past two decades, and concepts that have emerged from these developments are now well established. The surface modification of nanoparticles is a subject of intense research interest given its importance for many applications across a number of disciplines. This comprehensive guide is the first to be devoted to the surface chemistry of inorganic nanocrystals. Following an introduction to the physical chemistry of surfaces, chapters cover topics such as the surface modification of nanoparticles, water compatible, polymer-based, and inorganic nanocomposites, as well as relevant applications in catalysis, biotechnology and nanomedicine. Highlighting recent advances, Surface Chemistry of Colloidal Nanocrystals provides an integrated approach to chemical aspects related to the surface of nanocrystals. Written by prestigious scientists, this will be a useful resource for students and researchers working in surface science, nanoscience and materials science as well as those interested in the applications of the nanomaterials in areas such as health science, biology, and environmental engineering.

Smart External Stimulus Responsive Nanocarriers for Drug and Gene Delivery

Smart External Stimulus Responsive Nanocarriers for Drug and Gene Delivery Book
Author : Mahdi Karimi,Parham Sahandi Zangabad,Amir Ghasemi,Michael R Hamblin
Publisher : Morgan & Claypool Publishers
Release : 2015-12-01
ISBN : 1681742020
Language : En, Es, Fr & De

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Book Description :

The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo, this can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by enzymes in the body, to enhance the solubility of insoluble drugs, to extend the circulation half-life, and to enhance its penetration and accumulation at the target site. Importantly, smart nanocarriers can be designed to be responsive to a specific stimulus, so that the cargo is only released or activated when desired. In this volume we cover smart nanocarriers that respond to externally applied stimuli that usually involve application of physical energy. This physical energy can be applied from outside the body and can either cause cargo release, or can activate the nanostructure to be cytotoxic, or both. The stimuli covered include light of various wavelengths (ultraviolet, visible or infrared), temperature (increased or decreased), magnetic fields (used to externally manipulate nanostructures and to activate them), ultrasound, and electrical and mechanical forces. Finally we discuss the issue of nanotoxicology and the future scope of the field.

Single stranded RNA phages

Single stranded RNA phages Book
Author : Paul Pumpens
Publisher : CRC Press
Release : 2020-02-03
ISBN : 042967290X
Language : En, Es, Fr & De

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Book Description :

This is a comprehensive guide to single-stranded RNA phages (family Leviviridae), first discovered in 1961. These phages played a unique role in early studies of molecular biology, the genetic code, translation, replication, suppression of mutations. Special attention is devoted to modern applications of the RNA phages and their products in nanotechnology, vaccinology, gene discovery, evolutionary and environmental studies. Included is an overview of the generation of novel vaccines, gene therapy vectors, drug delivery, and diagnostic tools exploring the role of RNA phage-derived products in the revolutionary progress of the protein tethering and bioimaging protocols. Key Features Presents the first full guide to single-stranded RNA phages Reviews the history of molecular biology summarizing the role RNA phages in the development of the life sciences Demonstrates how RNA phage-derived products have resulted in nanotechnological applications Presents an up-to-date account of the role played by RNA phages in evolutionary and environmental studies

Applications of Encapsulation and Controlled Release

Applications of Encapsulation and Controlled Release Book
Author : Munmaya K. Mishra
Publisher : CRC Press
Release : 2019-09-18
ISBN : 1000576647
Language : En, Es, Fr & De

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Book Description :

The field of encapsulation, especially microencapsulation, is a rapidly growing area of research and product development. Applications of Encapsulation and Controlled Release offers a broad perspective on a variety of applications and processes, including, up-to-date research, figures, tables, illustrations, and references. Written at a level comprehensible to non-experts, it is a rich source of technical information and current practices in research and industry.

Thermosets

Thermosets Book
Author : Qipeng Guo
Publisher : Woodhead Publishing
Release : 2017-11-14
ISBN : 0081010281
Language : En, Es, Fr & De

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Book Description :

In this new edition, Thermosets: Structure, Properties, and Applications builds on and updates the existing review of mechanical and thermal properties, as well as rheology and curing processes of thermosets, and the role of nanostructures in thermoset toughening. All chapters have been updated or re-written, and new chapters have been added to reflect ongoing changes and developments in the field of thermosetting materials and the applications of these materials. Applications of thermosets are the focus of the second part of the book, including the use of thermosets in the building and construction industry, aerospace technology and as insulation materials. Thermoset adhesives and coatings, including epoxy resins, acrylates and polyurethanes are also discussed, followed by a review of thermosets for electrical applications. New chapters include coverage of thermoset nanocomposites, recycling issues, and applications such as consumer goods, transportation, energy and defence. With its distinguished editor and international team of expert contributors, the second edition of Thermosets: Structure, Properties, and Applications is an essential guide for engineers, chemists, physicists and polymer scientists involved in the development, production and application of thermosets, as well as providing a useful review for academic researchers in the field. Links structure, properties, and applications, making this book relevant to both academia and engineers in industry Includes entirely new chapters on the use of thermosets in aerospace, transport, defense, and a range of consumer applications Enables practitioners to stay current on the latest developments in recycling of thermosets and their composites

Nanoparticles for Biomedical Applications

Nanoparticles for Biomedical Applications Book
Author : Eun Ji Chung,Lorraine Leon,Carlos Rinaldi
Publisher : Elsevier
Release : 2019-11-19
ISBN : 0128166630
Language : En, Es, Fr & De

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Book Description :

Nanoparticles for Biomedical Applications: Fundamental Concepts, Biological Interactions and Clinical Applications brings into one place information on the design and biomedical applications of different classes of nanoparticles. While aspects are dealt with in individual journal articles, there is not one source that covers this area comprehensively. This book fills this gap in the literature. Outlines an in-depth review of biomedical applications of a variety of nanoparticle classes Discusses the major techniques for designing nanoparticles for use in biomedicine Explores safety and regulatory aspects for the use of nanoparticles in biomedicine