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Delivery Of Drugs

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Focal Controlled Drug Delivery

Focal Controlled Drug Delivery Book
Author : Abraham J. Domb,Wahid Khan
Publisher : Springer Science & Business Media
Release : 2014-02-17
ISBN : 1461494346
Language : En, Es, Fr & De

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Book Description :

The concept of focal controlled drug delivery has been applied for treating illnesses that are localized to a certain tissue or organ. These delivery systems are applied directly to the diseased site and deliver a desired dose for an extended time period while minimizing systemic distribution of toxic drug. Controlled drug delivery systems have been focused on oral extended release formulations and on systemic delivery of small drugs and peptides. Despite the upsurge of interest in focal targeted drug delivery, there is currently no single reference text on the subject. By comparison, there are numerous authored and edited books on oral, systemic and transdermal drug delivery or books on biodegradable polymers as drug carriers. Thus, the aim of Focal Drug Delivery is to bring together leading experts and researchers in the field to provide an authoritative account of the essential pharmaceutical, technological, physiological and biological sciences underpinning the topic. In addition, the book will review advances in treatment options for diseases localized at a certain tissue or organ.

Delivery of Drugs

Delivery of Drugs Book
Author : Ranjita Shegokar
Publisher : Elsevier
Release : 2020-02-01
ISBN : 0128177772
Language : En, Es, Fr & De

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Book Description :

Delivery of Drugs: Expectations and Realities of Multifunctional Drug Delivery Systems, Volume Two examines the formulation of micro-nanosized drug delivery systems and recaps opportunities for using physical methods to improve efficacy via mechano-, electroporation. The book highlights innovative delivery methods like PIPAC, including discussions on the regulatory aspects of complex injectables. Written by a diverse range of international researchers from industry and academia, the chapters examine specific aspects of characterization and manufacturing for pharmaceutical applications as well as regulatory and policy aspects. This book connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stakeholders. This level of discussion makes it a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about the status of drug delivery systems. Delivery of Drugs examines the fabrication, optimization, scale-up, biological aspects, regulatory and clinical success of various micro and nano drug delivery systems. The volume covers site and organ specific targeting approaches, technologies used in preparation of micro - nanoparticles, challenges of complex type of drug delivery forms and role of physical methods in achieving targeted drug effect. Written by a diverse range of international researchers the chapters examine the specific aspects of characterization and manufacturing of drug delivery system for pharmaceutical application and its regulatory aspects. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems.

Mucosal Delivery of Drugs and Biologics in Nanoparticles

Mucosal Delivery of Drugs and Biologics in Nanoparticles Book
Author : Pavan Muttil,Nitesh K. Kunda
Publisher : Springer Nature
Release : 2020-03-18
ISBN : 3030359107
Language : En, Es, Fr & De

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Book Description :

Nanotechnology has revolutionized the approach to designing and developing novel drug delivery systems. The last two decades have seen a great interest in the use of nanotechnology to offer efficient ways of delivering new and existing drugs and macromolecules. The focus of this book is the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes. It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. The emphasis is on the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs and acknowledges the concerns around the potential toxicity of nanoparticles to the host; several chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host’s immune cells is discussed. Moreover, it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book is the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.

Drug Delivery

Drug Delivery Book
Author : Binghe Wang,Longqin Hu,Teruna J. Siahaan
Publisher : John Wiley & Sons
Release : 2016-03-09
ISBN : 1118833309
Language : En, Es, Fr & De

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Book Description :

Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference. • Helps readers understand progress in drug delivery research and applications • Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics • Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics • Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery

Advances in Controlled Delivery of Drugs

Advances in Controlled Delivery of Drugs Book
Author : Melvyn Kohudic
Publisher : Routledge
Release : 2022-01-27
ISBN : 1351468413
Language : En, Es, Fr & De

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Book Description :

The development of improved methods of drug delivery has received significant attention over the last two decades. Most important is a non-toxic level of the drug at a particular body organ or body locale. To reach this goal, many variations of controlled release have been researched worldwide. This edited volume of papers from the Journal of Biomaterials Applications details many exciting technical advances in controlled release drug delivery systems. Some of the important developments described in the book include implantable delivery systems, delivery of topical drugs, and ultrasonic drug delivery.

Current Technologies To Increase The Transdermal Delivery Of Drugs

Current Technologies To Increase The Transdermal Delivery Of Drugs Book
Author : José Juan Escobar-Chávez
Publisher : Bentham Science Publishers
Release : 2010
ISBN : 1608051919
Language : En, Es, Fr & De

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Book Description :

This e-book provides an overview of current technologies used to increase the topical/transdermal delivery of drugs, its protocols, advantages and limitations. It includes exclusive chapters on chemical enhancers, Iontophoresis, Sonophoresis, Electroporation, Microneedles and the more recent use of micro/nanoparticles to deliver drugs throughout the skin. The e-book's generalized approach on the topic is aimed to be helpful in drug discovery, drug delivery and toxicological research and to provide a broader perspective on the topic to readers with respect to current literature available on the.

Fundamentals of Drug Delivery

Fundamentals of Drug Delivery Book
Author : Heather A. E. Benson,Michael S. Roberts,Adrian C. Williams,Xiaowen Liang
Publisher : John Wiley & Sons
Release : 2021-10-26
ISBN : 1119769604
Language : En, Es, Fr & De

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Book Description :

A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.

Drug Delivery and Targeting

Drug Delivery and Targeting Book
Author : Anya M. Hillery,Andrew W. Lloyd,James Swarbrick
Publisher : CRC Press
Release : 2002-01-24
ISBN : 9780415271974
Language : En, Es, Fr & De

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Book Description :

The advances in biotechnology and molecular biology over recent years have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of disease. However, such potential is severely compromised by significant obstacles to delivery of these drugs in vivo. These obstacles are often so great that effective drug delivery and targeting is now recognized as the key to effective development of many therapeutics. Advanced drug delivery and targeting can offer significant advantages to conventional drugs, such as increased efficiency, convenience, and the potential for line extensions and market expansion. An accessible and easy-to-read textbook, Drug Delivery and Targeting for Pharmacists and Pharmaceutical Scientists is the first book to provide a comprehensive introduction to the principles of advanced drug delivery and targeting, their current applications and potential future developments, including: *Methods to optimize therapeutic efficacy, and the related commercial implications *Difficulties with drug absorption, unwanted distribution and premature inactivation / elimination *Attempts to minimize toxicity or alter immunogenicity *Methods to achieve rate-controlled drug release and effective drug targeting *Novel and established routes of delivery *Use of new generation technologies such as biosensors, microchips, stimuli-sensitive hydrogels and plasmid-based gene therapy This volume is indispensable for pharmaceutical students, scientists and researchers.

Delivery Systems for Peptide Drugs

Delivery Systems for Peptide Drugs Book
Author : S.S. Davis,Lisbeth Illum,E. Tomlinson
Publisher : Springer Science & Business Media
Release : 2013-11-11
ISBN : 1475799608
Language : En, Es, Fr & De

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Book Description :

Recent years have seen enormous advances in the field of protein and peptide engineering and a greater understanding in the way in which biological response modifiers function in the body. It is now possible through the use of recombinant DNA techniques, or by solid phase protein synthesis, to produce significant quantities of a wide variety of regulatory agents that are therapeutically applicable. The list of these response modifiers expands almost daily to include interferons, macrophage activation factors, neuropeptides and agents that may have potential in cardiovascular disease, inflammation, contraception etc. Prospects to use some of these materials in medicine have reached the stage where products have either been approved by regulatory authorities or are the subject of applications as investigatory drugs or as new therapeutic agents. In some uses the pertinent agent will be administered on an acute basis in the form of a simple injection, as, for example, the use of a tissue plasminogen activator for the treatment of coronary infarct. In other cases regulatory proteins and peptides are indicated for chronic therapy and here they will need to be administered by an appropriate delivery system. Unfortunately, the research on delivery systems for peptides and proteins has not kept pace with the rapid progress in biotechnology and, consequently, there are presently few systems that are entirely appropriate for the administration of macromolecular drugs according to complex dosage regimens, (eg intermittent and pulsed therapy). Furthermore essential pharmacokinetic and pharmacodynamic data may be missing.

Drug Delivery Systems

Drug Delivery Systems Book
Author : Kewal K. Jain
Publisher : Humana Press
Release : 2010-10-28
ISBN : 9781617378287
Language : En, Es, Fr & De

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Book Description :

In this concise and systematic book, a team of experts select the most important, cutting-edge technologies used in drug delivery systems. They take into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular BiologyTM series format, offering readily reproducible results vital for pharmaceutical physicians and scientists.

Macromolecular Drug Delivery

Macromolecular Drug Delivery Book
Author : Mattias Belting
Publisher : Humana Press
Release : 2014-10-30
ISBN : 9781627039666
Language : En, Es, Fr & De

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Book Description :

Macromolecular drugs hold the promise of becoming new therapeutics for several major disorders, including cancer and cardiovascular disease. This incredible potential is explored in Macromolecular Drug Delivery, a volume which gives a wide-ranging overview of contemporary methods used in the field, and which addresses the limitations presented by a lack of safe and efficient drug delivery strategies. Chapters offer information on both in vitro and in vivo methods of macromolecular delivery, thus appealing to a broad scientific audience. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Macromolecular Drug Delivery offers a platform for interdisciplinary collaboration, which should provide opportunities for new discoveries at the interface between disciplines. Ultimately, this cooperation will lead to the use of macromolecular drugs as novel diagnostic tools and, even more importantly, as a means to revolutionize the way we view and treat diseases.

FASTtrack Pharmaceutics

FASTtrack Pharmaceutics Book
Author : Yvonne Perrie,Thomas Rades
Publisher : Pharmaceutical Press
Release : 2012
ISBN : 0857110594
Language : En, Es, Fr & De

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Book Description :

Pharmaceutics: Drug Delivery and Targeting focuses on what pharmacy students really need to know in order to pass exams, providing concise, bulleted information, chapter overviews, hints, key points, mind maps and an all-important self-assessment section which includes MCQs. This FASTtrack book systematically reviews important concepts and facts relating to the delivery and targeting of drugs. Relevant examples of delivery systems are given throughout the book with a focus on delivery systems that have actually reached clinical reality. Information is presented concisely with self assessment questions/answers and mindmaps to aid learning. The text has been updated for the new edition based on student feedback.

Drug Delivery Strategies for Poorly Water Soluble Drugs

Drug Delivery Strategies for Poorly Water Soluble Drugs Book
Author : Dionysios Douroumis,Alfred Fahr
Publisher : John Wiley & Sons
Release : 2012-12-19
ISBN : 1118444671
Language : En, Es, Fr & De

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Book Description :

Many newly proposed drugs suffer from poor water solubility,thus presenting major hurdles in the design of suitableformulations for administration to patients. Consequently, thedevelopment of techniques and materials to overcome these hurdles is a major areaof research in pharmaceutical companies. Drug Delivery Strategies for Poorly Water-Soluble Drugs providesa comprehensive overview of currently used formulation strategiesfor hydrophobic drugs, including liposome formulation, cyclodextrindrug carriers, solid lipid nanoparticles, polymeric drugencapsulation delivery systems, self–microemulsifying drugdelivery systems, nanocrystals, hydrosol colloidal dispersions,microemulsions, solid dispersions, cosolvent use, dendrimers,polymer- drug conjugates, polymeric micelles, and mesoporous silicananoparticles. For each approach the book discusses the maininstrumentation, operation principles and theoretical background,with a focus on critical formulation features and clinical studies. Finally, the bookincludes some recent and novel applications, scale-upconsiderations and regulatory issues. Drug Delivery Strategies for Poorly Water-Soluble Drugs is anessential multidisciplinary guide to this important area of drugformulation for researchers in industry and academia working indrug delivery, polymers and biomaterials.

Gibaldi s Drug Delivery Systems in Pharmaceutical Care

Gibaldi s Drug Delivery Systems in Pharmaceutical Care Book
Author : Mary Lee,Archana Desai
Publisher : ASHP
Release : 2007
ISBN : 1585281360
Language : En, Es, Fr & De

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Book Description :

It is important to make therapeutics a critical component of teaching about dosage forms and to make dosage forms and drug delivery systems an integral part of therapeutics. This book will be the first to focus on the therapeutic impact of drug dosage forms.Tying together concepts of traditional pharmaceutics with therapeutics, Drug Delivery Systemsin Pharmaceutical Care demonstrates how the modern clinical pharmacist can integrate knowledge in pharmaceutical sciences and therapeutics with appreciation of patient needs and nuances to advise on preferable and optimal product choices.Each chapter represents a collaboration of a clinical pharmacist practitioner and a pharmaceutical scientist. This unique perspective takes the science of dosage form design and helps translate the theory into the pragmatic.Special Features: Case studies and problems to help students get a better understanding of concepts Well-organized chapters with outlines and objectives Summary tables and helpful figures, along with reasonable compilations of original references Final sections with 'Learning Points' that reinforce essential material. Foreword by William J. Jusko, PhD, Professor and Chair, University of Buffalo, Department of Pharmaceutical Sciences

Spinal Drug Delivery

Spinal Drug Delivery Book
Author : Tony L. Yaksh
Publisher : Elsevier Science Health Science Division
Release : 1999
ISBN : 9780444829016
Language : En, Es, Fr & De

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Book Description :

This book provides a unified and comprehensive compendium of issues related to the spinal delivery of drugs. The text, consisting of 34 chapters, begins with an extensive review of the early history, reflecting the development of the spinal cord as a route of spinal drug delivery. It then presents 4 principal divisions. In the first, the embryology, anatomy of the spinal canal, the spinal canal meninges and vasculature are reviewed in humans and non-human species. The second division considers the factors that define the redistribution of spinally delivered drugs and the movements of such drugs into the spinal parenchyma are considered in detail. The third section considers issues that relate to the preclinical development of drugs for spinal delivery. This division includes issues that pertain to preclinical models for drug safety evaluation, the nature of vehicles for spinal drugs and properties of materials for chronic spinal implantation. In addition, the nature of the inflammatory reactions that are observed with foreign bodies and toxicity are presented. The fourth division considers the several therapeutic targets towards which spinally delivered drugs are aimed. These include analgesics, anesthetics, antispasticity, antimetastatic and growth factors. In each case, the site and mechanisms of action and the several drug classes that are relevant are presented. The book seeks to address the broad categories of interest that are represented by the scientists who focus on the biology of spinal cord function, the toxicologist and chemist who develop and formulate drugs for human spinal therapeutic use and the clinicians who seek an in-depth review of spinal drug delivery.

Nanocarriers for the Delivery of Combination Drugs

Nanocarriers for the Delivery of Combination Drugs Book
Author : Sanjula Baboota,Javed Ali
Publisher : Elsevier
Release : 2021-05-18
ISBN : 0128209402
Language : En, Es, Fr & De

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Book Description :

Nanocarriers for the Delivery of Combination Drugs focuses on the role of nanocarriers in the delivery of combination drugs for the management and treatment of various diseases. Nanocarriers belonging to the category of polymeric nanoparticles, dendrimers, lipidic nanocarriers (like nanoemulsions), liposomes, solid lipid nanoparticles, nanostructured lipid carriers are now being used in the drug delivery of combination drugs. This book helps readers assimilate all the information available surrounding the application of various nanocarrier technologies for the delivery of combination drugs of synthetic and natural origin, including small and large molecules. This is an important reference source for pharmaceutical scientists and biomaterials scientists who are looking to gain an increased understanding on how nanotechnology is improving the efficiency of combination drug delivery. Outlines how nanocarriers are used to enhance combination drug delivery systems Assesses the major challenges of delivering combination drugs successfully, and explains how nanocarriers can help meet these challenges Explores the characteristics of a variety of nanocarrier material types

Handbook of Lung Targeted Drug Delivery Systems

Handbook of Lung Targeted Drug Delivery Systems Book
Author : Yashwant Pathak,Nazrul Islam
Publisher : CRC Press
Release : 2021-10-17
ISBN : 1000450767
Language : En, Es, Fr & De

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Book Description :

Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals. Key Features: Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research. Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases Explores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications Examines specific formulations targeted to pulmonary systems

Mucosal Delivery of Drugs and Biologics in Nanoparticles

Mucosal Delivery of Drugs and Biologics in Nanoparticles Book
Author : Anonim
Publisher : Unknown
Release : 2020
ISBN : 9783030359119
Language : En, Es, Fr & De

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Book Description :

This book focuses on the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes.It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. Mucosal Delivery of Drugs and Biologics in Nanoparticles emphasize the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs. It acknowledges the concerns around the potential toxicity of nanoparticles to the host; few chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host's immune cells is discussed. Moreover,it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book will be the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.

Controlled Drug Delivery Systems

Controlled Drug Delivery Systems Book
Author : Emmanuel C. Opara
Publisher : CRC Press
Release : 2020-02-28
ISBN : 0429582757
Language : En, Es, Fr & De

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Book Description :

This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book: Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projections Examines the advantages and disadvantages of each drug delivery system Examines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomes Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.

Drug Delivery Systems

Drug Delivery Systems Book
Author : Peter Johnson,John Gareth Lloyd-Jones
Publisher : John Wiley & Sons
Release : 1987
ISBN : 9783527265589
Language : En, Es, Fr & De

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Book Description :

New drug delivery systems have been the focus of attention for the past 20 years. With a range of international contributions, this book summarizes current knowledge of site-specific, implantable, oral and other noninvasive (i.e. transdermal, nasal and ocular) systems, providing a comprehensive overview of the latest approaches to controlled release technology from both academic and industrial viewpoints. The authors not only present clear and concise accounts of current thinking, but additionally offer the reader some appropriate glimpses into the future, where the combination of drug delivery technology and advancing techniques in molecular biology and genetic engineering holds particular promise.