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Degradation Rate Of Bioresorbable Materials

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Degradation Rate of Bioresorbable Materials

Degradation Rate of Bioresorbable Materials Book
Author : F J Buchanan
Publisher : Elsevier
Release : 2008-09-26
ISBN : 1845695038
Language : En, Es, Fr & De

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Book Description :

Bioresorbable materials are extensively used for a wide range of biomedical applications from drug delivery to fracture fixation, and may remain in the body for weeks, months or even years. Accurately predicting and evaluating the degradation rate of these materials is critical to their performance and the controlled release of bioactive agents. Degradation rate of bioresorbable materials provides a comprehensive review of the most important techniques in safely predicting and evaluating the degradation rate of polymer, ceramic and composite based biomaterials. Part one provides an introductory review of bioresorbable materials and the biological environment of the body. Chapters in Part two address degradation mechanisms of commonly used materials such as polymers and ceramics. This is followed by chapters on bioresorption test methods and modelling techniques in Part three. Part four discusses factors influencing bioresorbability such as sterilisation, porosity and host response. The final section reviews current clinical applications of bioresorbable materials. With its distinguished editor and multidisciplinary team of international contributors, Degradation rate of bioresorbable materials: prediction and evaluation provides a unique and valuable reference for biomaterials scientists, engineers and students as well as the medical community. Comprehensively reviews the most pertinent techniques in safely predicting and evaluating the degradation rate of bioresorbable materials Addresses degradation mechanisms of commonly used materials Discusses factors influencing bioresorbability such as sterilisation and host response

Degradation of Poly lactide based Biodegradable Materials

Degradation of Poly  lactide   based Biodegradable Materials Book
Author : Hideto Tsuji
Publisher : Nova Science Pub Incorporated
Release : 2008-01-01
ISBN : 9781604565027
Language : En, Es, Fr & De

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Book Description :

Poly (lactide), i.e., poly (lactic acid) (PLA) is a biodegradable polyester produced from renewable resources. Due to its high mechanical performance and very low toxicity, PLA is utilised for biomedical, pharmaceutical, ecological, industrial, and commodity applications. PLA is susceptible to various types of degradation, such as hydrolytic degradation in the human body and the environment, biodegradation and photodegradation in the environment, and thermal degradation during processing. In biomedical and pharmaceutical applications, the hydrolytic degradation mechanism and rate are crucial factors for determining its performance. In contrast, in most of the environmental, industrial, and commodity applications, an accurate adjustment of the degradation rate as accurate as in biomedical and pharmaceutical applications is not required, or degradation during use can cause a reduction in material performance. However, for recycling PLA to its monomers, information on the mechanism and rate of hydrolytic degradation and thermal degradation at elevated temperatures is indispensable. This book deals with the hydrolytic degradation, biodegradation, thermal degradation, and photodegradation of PLA-based materials with different material factors and degradation conditions or environments.

Science and Principles of Biodegradable and Bioresorbable Medical Polymers

Science and Principles of Biodegradable and Bioresorbable Medical Polymers Book
Author : Xiang Cheng Zhang
Publisher : Woodhead Publishing
Release : 2016-09-22
ISBN : 0081003935
Language : En, Es, Fr & De

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Book Description :

Science and Principles of Biodegradable and Bioresorbable Medical Polymers: Materials and Properties provides a practical guide to the use of biodegradable and bioresorbable polymers for study, research, and applications within medicine. Fundamentals of the basic principles and science behind the use of biodegradable polymers in advanced research and in medical and pharmaceutical applications are presented, as are important new concepts and principles covering materials, properties, and computer modeling, providing the reader with useful tools that will aid their own research, product design, and development. Supported by practical application examples, the scope and contents of the book provide researchers with an important reference and knowledge-based educational and training aid on the basics and fundamentals of these important medical polymers. Provides a practical guide to the fundamentals, synthesis, and processing of bioresorbable polymers in medicine Contains comprehensive coverage of material properties, including unique insights into modeling degradation Written by an eclectic mix of international authors with experience in academia and industry

Modelling Degradation of Bioresorbable Polymeric Medical Devices

Modelling Degradation of Bioresorbable Polymeric Medical Devices Book
Author : J Pan
Publisher : Elsevier
Release : 2014-10-24
ISBN : 1782420258
Language : En, Es, Fr & De

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Book Description :

The use of bioresorbable polymers in stents, fixation devices and tissue engineering is revolutionising medicine. Both industry and academic researchers are interested in using computer modelling to replace some experiments which are costly and time consuming. This book provides readers with a comprehensive review of modelling polymers and polymeric medical devices as an alternative to practical experiments. Chapters in part one provide readers with an overview of the fundamentals of biodegradation. Part two looks at a wide range of degradation theories for bioresorbable polymers and devices. The final set of chapters look at advances in modelling biodegradation of bioresorbable polymers. This book is an essential guide to those concerned with replacing tests and experiments with modelling. Provides a comprehensive mathematical framework for computer modelling of polymers and polymeric medical devices that can significantly reduce the number of experiments needed. Reviews the fundamental methods of modelling degradation, and applies these to particular materials including amorphous bioresorbable polyesters, semicrystalline biodegradable polyesters, and composite materials made of biodegradable polyesters and triclcium phosphates

Handbook of Composites from Renewable Materials Biodegradable Materials

Handbook of Composites from Renewable Materials  Biodegradable Materials Book
Author : Vijay Kumar Thakur,Manju Kumari Thakur,Michael R. Kessler
Publisher : John Wiley & Sons
Release : 2017-02-17
ISBN : 1119224381
Language : En, Es, Fr & De

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Book Description :

The Handbook of Composites From Renewable Materials comprises a set of 8 individual volumes that brings an interdisciplinary perspective to accomplish a more detailed understanding of the interplay between the synthesis, structure, characterization, processing, applications and performance of these advanced materials. The handbook covers a multitude of natural polymers/ reinforcement/ fillers and biodegradable materials. Together, the 8 volumes total at least 5000 pages and offers a unique publication. This 5th volume Handbook is solely focused on Biodegradable Materials. Some of the important topics include but not limited to: Rice husk and its composites; biodegradable composites based on thermoplastic starch and talc nanoparticles; recent progress in biocomposites of biodegradable polymer; microbial polyesters: production and market; biodegradable and bio absorbable materials for osteosynthesis applications; biodegradable polymers in tissue engineering; composites based on hydroxyapatite and biodegradable polylactide; biodegradable composites; development of membranes from bio-based materials and their applications; green biodegradable composites based on natural fibers; fully biodegradable all-cellulose composites; natural fiber composites with bio-derivative and/or degradable polymers; synthetic biodegradable polymers for bone tissue engineering; polysaccharides as green biodegradable platforms for building-up electroactive composite materials; biodegradable polymer blends and composites from seaweeds; biocomposites scaffolds derived from renewable resources for bone tissue repair ; pectin-based composites; recent advances in conductive composites based on biodegradable polymers for regenerative medicine applications; biosynthesis of PHAs and their biomedical applications; biodegradable soy protein isolate/poly (vinyl alcohol) packaging films and biodegradability of bio-based polymeric materials in natural environment.

Bioresorbable Polymers and their Biomedical Applications

Bioresorbable Polymers and their Biomedical Applications Book
Author : Declan M Devine
Publisher : Smithers Rapra
Release : 2017-04-10
ISBN : 1911088092
Language : En, Es, Fr & De

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Book Description :

Bioresorbable or biodegradable polymers are commonly used in various biomedical applications. The application of bioresorbable polymers in the biomedical sector has been widely exploited by immobilising suturing thread with an analgesic or antibacterial drugs, and the development of bioresorbable vascular scaffolds, wound-healing and intravenous drug-delivery devices. Furthermore, biodegradable polymers have been investigated as a replacement for metallic orthopaedic devices due to their precise control of material composition and microstructure. These polymers are eliminated from the body via dissolution, assimilation and excretion through metabolic pathways. The hydrolysing process breaks down the polymer into smaller units and its degradation products are excreted by means of the citric acid cycle or by direct renal excretion with no residual side effects.Processing of bioresorbable implants can be achieved via conventional polymer processing methods such as extrusion, injection and compressing moulding, solvent spinning or casting. However, special consideration must be given when processing these materials because heat can cause a reduction in molecular weight due to the hydrolysing of bonds. In addition, overheating can depolymerise the polymer and, as a result, monomers can have a plasticising effect on the polymer. Recently, alternative approaches utilising rapid prototyping and micro-/nanofabrication processes have been employed.This book addresses these issues and highlights recent advances in the biomedical field that have being enabled by the use of biodegradable polymers. This book is designed as a reference guide for academic researchers utilising biodegradable polymers in a range of areas from tissue engineering to controlled release of active pharmaceuticals, through to industry-based processors of biodegradable polymers.

Durability and Reliability of Medical Polymers

Durability and Reliability of Medical Polymers Book
Author : Mike Jenkins,Artemis Stamboulis
Publisher : Elsevier
Release : 2012-08-13
ISBN : 0857096516
Language : En, Es, Fr & De

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Book Description :

Given the widespread use of polymers in medical devices, the durability and reliability of this material in use is an area of critical importance. Durability and reliability of medical polymers reviews the performance of both bioresorbable and non-bioresorbable medical polymers. Part one provides a review of the types and properties of bioresorbable medical polymers. The effect of molecular structure on properties is discussed, along with the processing of bioresorbable and other polymers for medical applications. Transport phenomena and the degradation of bioresorbable medical polymers are reviewed, before an exploration of synthetic bioresorbable polymers and their use in orthopaedic tissue regeneration. Part two goes on to explore the durability and reliability of non-bioresorbable medical polymers, and wear processes in polymer implants and ageing processes of biomedical polymers in the body are discussed in depth, before an investigation into manufacturing defects and the failure of synthetic polymeric medical devices. With its distinguished editors and international team of expert contributors, Durability and reliability of medical polymers is an essential tool for all materials scientists, researchers and engineers involved in the design, development and application of medical polymers, whilst also providing a helpful overview of the subject for biologists, chemist and clinicians. Comprehensively examines the performance of both bioresorbable and non-bioresorbable medical polymers Discusses the processing of bioresorbable and other polymers for medical applications, before reviewing the degradation of bioresorbable medical polymers Explores the durability and reliability of non-bioresorbable medical polymers and discusses wear processes in polymer implants and ageing processes of biomedical polymers in the body

Degradable Polymers

Degradable Polymers Book
Author : G. Scott,D. Gilead
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 9401105715
Language : En, Es, Fr & De

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Book Description :

Few scientific developments in recent years have captured the popular imagination like the subject of'biodegradable' plastics. The reasons for this are complex and lie deep in the human subconscious. Discarded plastics are an intrusion on the sea shore and in the countryside. The fact that nature's litter abounds in the sea and on land is acceptable because it is biodegradable - even though it may take many years to be bioassimilated into the ecosystem. Plastics litter is not seen to be biodegradable and is aesthetically unacceptable because it does not blend into the natural environment. To the environmentally aware but often scientifically naive, biodegradation is seen to be the ecologically acceptable solution to the problem of plastic packaging waste and litter and some packaging manufacturers have exploited the 'green' consumer with exaggerated claims to 'environmentally friendly' biodegradable packaging materials. The principles underlying environmental degradation are not understood even by some manufacturers of 'biodegradable' materials and the claims made for them have been categorized as 'deceptive' by USA legislative authorities. This has set back the acceptance of plastics with controlled biodegradability as part of the overall waste and litter control strategy. At the opposite end of the commercial spectrum, the polymer manufactur ing industries, through their trade associations, have been at pains to discount the role of degradable materials in waste and litter management. This negative campaign has concentrated on the supposed incompatibility of degradable plastics with aspects of waste management strategy, notably materials recycling.

Bioresorbable Polymers

Bioresorbable Polymers Book
Author : Declan Devine
Publisher : Walter de Gruyter GmbH & Co KG
Release : 2019-04-15
ISBN : 3110640570
Language : En, Es, Fr & De

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Book Description :

Bioresorbable implants can be processed via conventional polymer processing methods such as extrusion, injection and compressing moulding, solvent spinning or casting. This book addresses issues and highlights recent advances in the use of biodegradable polymers. It is intended for researchers utilizing biodegradable polymers in areas from tissue engineering to controlled release of active pharmaceuticals, as well as industrial processors.

A Phenomenological Mathematical Modelling Framework for the Degradation of Bioresorbable Composites

A Phenomenological Mathematical Modelling Framework for the Degradation of Bioresorbable Composites Book
Author : Ismael Moreno-Gomez
Publisher : Springer
Release : 2019-04-05
ISBN : 3030049906
Language : En, Es, Fr & De

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Book Description :

This book presents a generalised computational model for the degradation of resorbable composites, using analytic expressions to represent the interwoven phenomena present during degradation. It then combines this modelling framework with a comprehensive database of quantitative degradation data mined from existing literature and from novel experiments, to provide new insights into the interrelated factors controlling degradation. Resorbable composites made of biodegradable polyesters and calcium-based ceramics have significant therapeutic potential as tissue engineering scaffolds, as temporary implants and as drug-loaded matrices for controlled release. However, their degradation is complex and the rate of resorption depends on multiple connected factors such as the shape and size of the device, polymer chemistry and molecular weight, particle phase, size, volume fraction, distribution and pH-dependent dissolution properties. Understanding and ultimately predicting the degradation of resorbable composites is of central importance if we are to fully unlock the promise of these materials.

Biodegradable Polymers in Pharmacy and Medicine Classification Chemical Structure Principles of Biodegradation and Use

Biodegradable Polymers in Pharmacy and Medicine  Classification  Chemical Structure  Principles of Biodegradation and Use Book
Author : Jan Gajdziok,Roman Goněc,David Vetchý
Publisher : GRIN Verlag
Release : 2016-09-13
ISBN : 3668297754
Language : En, Es, Fr & De

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Book Description :

Document from the year 2016 in the subject Medicine - Pharmacology, , course: Pharmaceutical technology, language: English, abstract: The aim of this book is to provide a brief but comprehensive overview on the issue of biodegradable polymers. The introduction chapter is followed by a description of the general characteristics of biodegradable polymers and pathways of their degradation in the human body. Particular pitfalls and specifics of their various biomedical and pharmaceutical applications, especially in the field of pharmaceutical technology, are described in order to define the ideal carrier polymer system for specific types of therapy. Finally, the work presents the classification of these polymers based on the type of degradation mechanism. This section also includes the chemical structure of particular polymer molecules, their chemical or bio-synthesis and the description of their uses in specific biomedical and pharmaceutical applications. The book could be used as a textbook for students of medical and pharmaceutical sciences as well as by researchers in this field or industrial area. In the past few decades, biodegradable polymers have reached significant importance in fields of biomedical and pharmaceutical applications. They have become preferred candidates for the manufacture of therapeutic forms, for instance, orthopaedics devices, temporary bone screws and spins, three-dimensional scaffolds for tissue engineering or drug delivery systems for sustained and targeted release. Each of these applications requires material with specific physical, biological, and chemical properties, as well as specific degradation profile. These polymers (natural or synthetic) undergo hydrolytic or enzymatic degradation, which both have some advantages and disadvantages. Most widely used polymer materials in biomedical applications are listed, including their structure and degradation pathways.

Annual Review of Materials Research

Annual Review of Materials Research Book
Author : Anonim
Publisher : Unknown
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Annual Review of Materials Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Bioresorbable Materials and Their Application in Electronics

Bioresorbable Materials and Their Application in Electronics Book
Author : Xian Huang
Publisher : Cambridge University Press
Release : 2017-11-16
ISBN : 1108314007
Language : En, Es, Fr & De

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Book Description :

Bioresorbable electronics that can dissolve away in aqueous environments and generate biologically safe products offer a revolutionary solution to replace the built-to-last electronics predominantly used in implanted devices and electronic gadgets. Their use can reduce the risk of surgical complications by minimizing the number of necessary surgeries, and prevent production of electronic waste by allowing rapid device recycling. This Element presents bioresorbable materials such as metals, polymers, inorganic compounds, and semiconductors that have been used to construct electronic devices, and analyzes their unique dissolution behaviors and biological effects. These materials are combined to yield representative devices including passive and active components and functional systems.

Handbook of Biodegradable Polymeric Materials and Their Applications Applications

Handbook of Biodegradable Polymeric Materials and Their Applications  Applications Book
Author : Surya Mallapragada,Balaji Narasimhan
Publisher : Unknown
Release : 2006
ISBN : 9781588830555
Language : En, Es, Fr & De

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Book Description :

Download Handbook of Biodegradable Polymeric Materials and Their Applications Applications book written by Surya Mallapragada,Balaji Narasimhan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Handbook of Biodegradable Polymers

Handbook of Biodegradable Polymers Book
Author : Andreas Lendlein,Adam Sisson
Publisher : John Wiley & Sons
Release : 2011-09-19
ISBN : 3527635823
Language : En, Es, Fr & De

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Book Description :

A comprehensive overview of biodegradable polymers, covering everything from synthesis, characterization, and degradation mechanisms while also introducing useful applications, such as drug delivery systems and biomaterial-based regenerative therapies. An introductory section deals with such fundamentals as basic chemical reactions during degradation, the complexity of biological environments and experimental methods for monitoring degradation processes. The result is a reliable reference source for those wanting to learn more about this important class of polymer materials, as well as scientists in the field seeking a deeper insight.

Canadian Journal of Chemistry

Canadian Journal of Chemistry Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Canadian Journal of Chemistry book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Investigation of a HA PDLGA carbon Foam Material System for Orthopedic Fixation Plates Based on Time dependent Properties

Investigation of a HA PDLGA carbon Foam Material System for Orthopedic Fixation Plates Based on Time dependent Properties Book
Author : Douglas E. Rodriguez
Publisher : Unknown
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

While there is continuing interest in bioresorbable materials for orthopedic fixation devices, the major challenge in utilizing these materials in load-bearing applications is creating materials sufficiently stiff and strong to sustain loads throughout healing while maintaining fracture stability. The primary aim of this study is to quantify the degradation rate of a bioresorbable material system, then use this degradation rate to determine the material response of an orthopedic device made of the same material as healing progresses. The present research focuses on the development and characterization of a material system consisting of carbon foam infiltrated with hydroxyapatite (HA) reinforced poly(D, L-lactide)-co-poly(glycolide) (PDLGA). A processing technique is developed to infiltrate carbon foam with HA/PDLGA and material morphology is investigated. Additionally, short-term rat osteoblast cell studies are undertaken to establish a starting point for material biocompatibility. Degradation experiments are conducted to elicit the time-dependent properties of the material system at the material scale. These properties are then incorporated into computational models of an internal plate attached to a fractured human femur to design and predict the material response to applied physiological loads. Results from this work demonstrate the importance of material dissolution rate as well as material strength when designing internal fixation plates.

Progresses in Fracture and Strength of Materials and Structures

Progresses in Fracture and Strength of Materials and Structures Book
Author : Yu Zhou,Shan-Tung Tu,Xishan Xie
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Progresses in Fracture and Strength of Materials and Structures book written by Yu Zhou,Shan-Tung Tu,Xishan Xie, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Materials World

Materials World Book
Author : Anonim
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Materials World book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.