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Crispr Genome Surgery In Stem Cells And Disease Tissues

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Crispr Genome Surgery in Stem Cells and Disease Tissues

Crispr Genome Surgery in Stem Cells and Disease Tissues Book
Author : Stephen H. Tsang
Publisher : Academic Press
Release : 2020-08-03
ISBN : 9780128178768
Language : En, Es, Fr & De

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Book Description :

CRISPR Genome Surgery in Stem Cells and Disease Tissues focuses uniquely on the clinical applications of CRISPR/Cas9 based technology. Topics include the latest advances in gene editing and its translational applications to various diseases, including retinal degenerative disease, recessively inherited diseases, and dominantly inherited diseases, to name a few. The book's target audience includes researchers, students, clinicians and the general public. This space that is not currently served by any existing resource, so this publication fills a gap in current literature.

Proceedings of 7th International Conference and Exhibition on Cell and Gene Therapy 2018

Proceedings of 7th International Conference and Exhibition on Cell and Gene Therapy 2018 Book
Author : ConferenceSeries
Publisher : ConferenceSeries
Release : 2021-10-19
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

March 15-16, 2018 London,UK Key Topics : Stem Cell Therapies, Cell Culture and Bioprocessing, Viral Gene Therapy, Gene and Cell Therapy for Rare & Common Diseases, Tissue Science & Regenerative Medicine, Molecular Basis of Epigenetics, Clinical Trials on Cell & Gene Therapy, Cell Science and Stem Cell Research, Bioengineering Therapeutics, Nano Therapy, Gene Editing Technology, Advanced Gene Therapeutics, Genetics & Genomic Medicine, Ethical Issues in Cell and Gene Therapy, Markets & Future Prospects for Cell & Gene Therapy, Cell Therapy, Gene Therapy, Cell Therapy of Cardiovascular Disorders, Cell Therapy for Neurological Disorders, Regulatory and Safety Aspects of Cell and Gene Therapy, Commercialization,

Success in Academic Surgery Basic Science

Success in Academic Surgery  Basic Science Book
Author : Gregory Kennedy,Ankush Gosain,Melina Kibbe,Scott A. LeMaire
Publisher : Springer
Release : 2019-04-29
ISBN : 3030146448
Language : En, Es, Fr & De

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Book Description :

This updated volume provides the foundation for starting a basic science research career as an academic surgeon. Taking a practical approach, the book covers the suggested timeline for the initial academic appointment, including how to setup and fund the laboratory and identifying appropriate scientific mentors and lab personnel. It also describes the application of basic and advanced research techniques, including animal models, flow cytometry, gene editing, tissue engineering, and microbiome analysis. Success in Academic Surgery: Basic Science aims to give guidance on the application of basic and advanced techniques in surgical research. This book is relevant to senior residents and fellows approaching their first academic appointment, as well as more senior investigators interested in expanding their research horizons.

Cells Are the New Cure

Cells Are the New Cure Book
Author : Robin L. Smith
Publisher : BenBella Books
Release : 2017-10-24
ISBN : 1944648844
Language : En, Es, Fr & De

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Book Description :

The future of medicine is happening now. Revolutionary new science is providing cures that were considered science fiction just a few years ago—and not with pills, surgery, or radiation, but with human cells. Promising treatments now in extensive clinical trials could have dramatic impacts on cancer, autoimmune diseases, organ replacement, heart disease, and even aging itself. The key to these breakthroughs is the use of living cells as medicine instead of traditional drugs. Discover the advances that are alleviating the effects of strokes, Alzheimer's disease, and even allergies. Cells Are the New Cure takes you into the world of regenerative medicine, which enables doctors to repair injured and aging tissues and even create artificial body parts and organs in the lab. Cellular medicine experts Robin L. Smith, MD, and Max Gomez, PhD, outline the new technologies that make it possible to harness the immune system to fight cancer and reverse autoimmune diseases like multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. CRISPR, a new technology for targeted gene editing, promises to eradicate genetic diseases, allowing us to live longer lives—possibly even beyond age 100 in good health. Cells Are the New Cure takes you on a tour of the most exciting and cutting-edge developments in medicine. The content inside these pages could save your life or the life of someone you love.

Stem Cells for Cancer and Genetic Disease Treatment

Stem Cells for Cancer and Genetic Disease Treatment Book
Author : Phuc Van Pham,Ahmed El-Hashash
Publisher : Springer
Release : 2018-11-07
ISBN : 3319980653
Language : En, Es, Fr & De

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Book Description :

This invaluable resource discusses insights ranging from basic biological mechanisms of various types of stem cells through the potential applications in the treatment of human diseases, including cancer and genetic disorders. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in understanding different types of stem cell biology and their potential applications in tissue repair and regeneration and in the treatment different types of human cancer and genetic diseases or disorders. Stem Cells for Cancer and Genetic Disease Treatment and the other books in the Stem Cells in Clinical Applicationsseries will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering as well as cancer or genetics research.

Genome Editing and Engineering

Genome Editing and Engineering Book
Author : Krishnarao Appasani
Publisher : Cambridge University Press
Release : 2018-07-31
ISBN : 1107170370
Language : En, Es, Fr & De

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Book Description :

A complete guide to endonuclease-based genomic engineering, from basic science to application in disease biology and clinical treatment.

Plastic Surgery Principles and Practice E Book

Plastic Surgery   Principles and Practice E Book Book
Author : Rostam Farhadieh,Neil Bulstrode,Babak J. Mehrara,Sabrina Cugno
Publisher : Elsevier Health Sciences
Release : 2021-04-22
ISBN : 0323653820
Language : En, Es, Fr & De

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Book Description :

With detailed, expert guidance on each essential topic, Plastic Surgery: Principles and Practice offers single-volume convenience without sacrificing complete coverage of this multi-faceted field. Written by global leading authorities, it provides concise, easy-to-follow instruction with the clinical details and supportive data needed to achieve optimal patient outcomes. Offers thorough coverage of facelift procedures, rhinoplasty, otoplasty and more, along with clinical pearls from masters in the field. Features hundreds of high-quality images including anatomical line art, case photos, and procedural operative photos. I Includes a superb selection of procedural videos of global experts performing key techniques within operating room and close-up clinical pearls. An ideal resource for residents, fellows, and practitioners in plastic surgery, as well as those in otolaryngology, vascular surgery, and cosmetic dermatology.

Regulation of Intestinal Stem Cell Niche and Colon Cancer

Regulation of Intestinal Stem Cell Niche and Colon Cancer Book
Author : Kuei-Ling Tung
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The intestine is one of the fastest regenerative tissues in the body, and homeostasis of the tissue requires robust regulations of intra- and inter-cellular signaling. The stem cells reside at crypt bottom of intestinal epithelium serve as the workhorse of tissue regeneration and keep the tissue homeostasis. When dysregulated events occur to normal intestine cells, cancerous cells often emerge with unchecked cell growth and perturbed cell death, and escape from rigorous mechanisms of cellular signaling regulations. Colorectal cancer (CRC) is one of the most common cause of cancer deaths. Current treatments include surgery and chemotherapy, but disease recurrence occurs frequently. The continuous renewal of intestinal epithelium relies on the presence of intestinal stem cells that could be at the origin of CRC and contribute to therapy resistance and metastases. Several cell signaling pathways and regulatory elements involve in both intestinal cell homeostasis and tumorigenesis. My studies focus on understanding the regulation in intestinal stem cell niche and applying transcriptome and chromatin accessibility profiling to investigate drug resistance in colon cancer. Tissue homeostasis requires rigorous control mechanisms for stem cell division and maintenance of a stable stem cell niche. In the intestinal stem cell (ISC) niche, ISCs and Paneth cells form a stable pattern to control stem cell behavior. However, how is the stem cell niche pattern dynamically regulated and maintained in a rapid regenerative environment still remains unclear. We stimulated intestinal organoids with Notch ligands and inhibitors and discovered that intestinal stem cells employ a positive feedback mechanism via direct Notch binding to the second intron of the Notch1 gene. Inactivation of the positive feedback by CRISPR/Cas9 mutation of the binding sequence alters the mosaic stem cell niche pattern and hinders regeneration in organoids. This study highlights the importance of Notch 1 positive feedback mechanisms in spatiotemporal control of the stem cell niche. Patients with advanced colorectal cancer (CRC) develop chemoresistance to current standard-of-care therapies. We used patient-derived organoids (PDO) from metastatic CRC patients and integrated chromatin and transcriptomic profiling to show that resistant tumor cells remodel their chromatin in response to chemotherapy. Personalized therapy with pharmacological inhibitor of FGFR1 or OXTR, two novel targets for resistant CRC, circumvents oxaliplatin resistance. This study demonstrates the combination of PDO and integrated chromatin/transcriptomic analysis as a potential precision medicine platform to overcome chemoresistance.

Gene Therapy in Reconstructive and Regenerative Surgery

Gene Therapy in Reconstructive and Regenerative Surgery Book
Author : Giorgio Giatsidis
Publisher : Springer
Release : 2018-08-02
ISBN : 3319789570
Language : En, Es, Fr & De

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Book Description :

This book offers an updated overview of the most recent research advances in the field, a comparison of established techniques and methods, a discussion on current experimental and translational challenges, and a commentary on potential opportunities and future directions. Dedicated chapters address and review the preclinical and clinical state-of-the-art of gene therapies for the reconstructive and regenerative surgery of skin and wounds, pathological scars, cartilage, tendons, skeletal muscles, and bio-engineered flaps. A brief guide to developing gene therapy clinical trials in the context of reconstructive and regenerative surgery is also provided. Biomedical and technological innovations are transforming our capacity to use gene therapies to safely and effectively repair, reconstruct, and regenerate tissues that are deficient or have been damaged by trauma and diseases. The targeted and controlled modulation of gene expression in tissues represents a game-changing, next-generation therapeutic tool for the modern reconstructive surgeon, expanding the horizon of regenerative surgery and tissue engineering. Through gene therapies, surgeons can direct (stem) cell differentiation and cell function, modulate the release of growth/transcriptional factors, affect the biological properties of regenerative scaffolds, control tissue inflammation, or induce immune-suppression in composite tissue allotransplants and xenotransplants. Written by renowned reconstructive surgeons and leading experts in each of these fields - from top academic institutions around the globe, the book provides an initial practical guide for veteran and newcomer surgeons alike, as well as for researchers interested in exploring the latest gene-based therapeutic strategies for reconstructive and regenerative surgery.

Corneal Regeneration

Corneal Regeneration Book
Author : Jorge L. Alió,Jorge L. Alió del Barrio,Francisco Arnalich-Montiel
Publisher : Springer
Release : 2019-02-20
ISBN : 3030013049
Language : En, Es, Fr & De

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Book Description :

This text provides expert instruction on the varying surgical techniques currently employed for the regeneration of the ocular surface. Corneal Regeneration: Therapy and Surgery begins with a thorough discussion of current research based on data obtained in clinical human studies, and discusses the potential clinical implications for this promising new stage of eye surgery. Sections devoted to the stem cell, regenerative surgery and therapy of the ocular surface epithelium, corneal stroma, and corneal endothelium follow, each section comprehensively covering applied anatomy, current therapy and regenerative techniques, with a look to future directions of the field including eventual cell therapy. Corneal Regeneration: Therapy and Surgery is the first book of its kind, systematically covering the developments the medical community has achieved in corneal regeneration from all angles. Written and edited by leading experts in the field, researchers and ophthalmologists alike will find this to be a unique source of information on corneal regeneration, as well as a thoughtful reflection on potential applications of regenerative surgery in ophthalmology as a whole.

Cellular Therapies for Retinal Disease

Cellular Therapies for Retinal Disease Book
Author : Steven D. Schwartz,Aaron Nagiel,Robert Lanza
Publisher : Springer
Release : 2017-06-20
ISBN : 3319494791
Language : En, Es, Fr & De

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Book Description :

This book familiarizes the reader with the current landscape of cell-based therapies for the treatment of retinal disease, including diseases that affect the choriocapillaris, retinal pigment epithelium, photoreceptors, and retinal ganglion cells. Instead of utilizing a disease-centric approach to the topic, this book—edited by two world-renowned stem cell scientists—focuses on strategies for developing and transplanting the cells. This includes the creation of replacement cells, cell-based neuroprotection, and in vitro disease modeling and testing. The final chapters briefly review parallel approaches that do not directly utilize cellular transplantation. The use of cellular transplantation to treat retinal disease has recently become a viable and exciting therapeutic approach. The visibility of the retina and its laminar cellular architecture render it an ideal organ for the development of surgically delivered cellular therapies. Having an in-depth understanding of the current state of cell therapy for the eye is an essential first step toward utilizing similar approaches in other organs. Ophthalmologists, translational clinician-scientists, stem cell scientists, and researchers interested in eye disease will find Cellular Therapies for Retinal Disease: A Strategic Approach essential reading and it is also suitable for workshops or courses at the undergraduate or Ph.D. level.

Cancerland

Cancerland Book
Author : David Scadden,Michael D'Antonio
Publisher : Thomas Dunne Books
Release : 2018-07-10
ISBN : 1250092779
Language : En, Es, Fr & De

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Book Description :

An Amazon Best of the Month Book "For all the insight he offers into the hard science and thorny logistics of studying cancer, Dr. Scadden’s most moving passages consider the effect of the disease on the people who suffer from it and those who care for them." —The Wall Street Journal A doctor’s riveting story of loss and hope in the world of cancer. What is it like to encounter cancer? How does it feel to face the unknown, to enter a world of hope, loss, and dread? From the diagnosis of his childhood friend’s mother to his poignant memories in the lab, David Scadden’s seen the unknown world of cancer from the lens of a young boy, a classmate, a researcher, a friend, a doctor, and a neighbor. Scadden chronicles his personal memories of cancer – his visits to his sick neighbor and his classmate who left school and never came back. Now Dr. David Scadden, co-founder of the Harvard Stem Cell Institute and one of the world's leading experts on immunology and oncology, writes his memoir, Cancerland, with Pulitzer Prize-winning journalist Michael D'Antonio. With riveting stories and moving compassion, Scadden and D’Antonio paint a still rapidly changing landscape in the context of all too common stories of loss. Ranging from Scadden’s personal childhood memories to his triumphs and regrets as a doctor, Scadden illuminates a light at the end of a dark tunnel. Through opening a window into the science of medicine in the world of the unknown, Scadden and D’Antonio humanize cancer while inspiring action that we all so desperately need.

Single Cell Biomedicine

Single Cell Biomedicine Book
Author : Jianqin Gu,Xiangdong Wang
Publisher : Springer
Release : 2018-06-25
ISBN : 9811305021
Language : En, Es, Fr & De

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Book Description :

The book focuses on various detection targets applied in single cell studies, including tumor tissue cells, circulating tumor cells (CTCs), disseminated tumor cells (DTCs), circulating tumor DNA (ctDNA), cell-free DNA (cfDNA) and cancer stem cells (CSCs). It also discusses and compares detection methods using these detection targets in different fields to reveal single cell biomedical functions. The volume focuses not only on the methods already been established and validated, and also the methods newly developed. The book also highlights the importance and potential of single cell biomedicine in the development and validation of precision medicine strategies. It is useful for researchers and students in the field of cell biology, molecular medicine and precision medicine etc.

Crohn s Disease and Ulcerative Colitis

Crohn s Disease and Ulcerative Colitis Book
Author : Daniel C. Baumgart
Publisher : Springer
Release : 2017-03-01
ISBN : 3319337033
Language : En, Es, Fr & De

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Book Description :

This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field. Written by experts in their field, Crohn’s Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis, and related autoimmune disorders.

The Columbia Guide to Basic Elements of Eye Care

The Columbia Guide to Basic Elements of Eye Care Book
Author : Daniel S. Casper,George A. Cioffi
Publisher : Springer
Release : 2019-07-01
ISBN : 3030108864
Language : En, Es, Fr & De

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Book Description :

This unique resource is a practical, easy-to-use guide for the non-ophthalmologist healthcare provider as they encounter patients with eye complaints and other concerning ophthalmic conditions. The Columbia Guide to Basic Elements of Eye Care is specifically designed with the non-ophthalmologist in mind, and provides a foundation of basic eye anatomy and physiology, functional analysis, pathology, and concepts in eye care. Each chapter delivers an accessible summary of various ophthalmic diseases and conditions, all of which are frequently encountered in everyday practice. These chapters provide in-depth discussions on a wide range of topics, from testing and examination procedures to management protocols, referral guidelines and expected frequency of follow-up for each disorder. Complete with hundreds of high-quality, descriptive illustrations and clinical photographs, The Columbia Guide to Basic Elements of Eye Care presents clear, understandable explanations of basic eye anatomy, physiology, disease and treatment for non-ophthalmic practitioners and students. In doing so, this guide provides a framework for determining the normal versus the abnormal, helping the reader recognize which patients require referral, and identify which conditions are developing, require urgent treatment, or can be routinely followed. Non-ophthalmologist healthcare providers and students alike will find this book, written by leaders in the field, a practical resource to consult as they encounter patients with treatable but potentially sight-threatening conditions.

Bioentrepreneurship and Transferring Technology Into Product Development

Bioentrepreneurship and Transferring Technology Into Product Development Book
Author : Agarwal, Swati,Kumari, Sonu,Khan, Suphiya
Publisher : IGI Global
Release : 2021-06-25
ISBN : 1799874133
Language : En, Es, Fr & De

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Book Description :

In terms of becoming a successful bioentrepreneur, there is still much more to learn. There are many ways to learn the essential fundamentals of entrepreneurship, including through the mistakes of previous businesses and models. Increased knowledge and a better understanding of what works can be derived from these previous failures and mistakes. Additionally, learning from other bioentrepreneurs can help businesses run successfully. By looking deeper into business models, product development, the fundamental concepts of bioentrepreneurship, and the essential characteristics of bioentrepreneurs, one can become better equipped to understand the role of biological sciences in entrepreneurship, specifically the role of product development. Bioentrepreneurship and Transferring Technology Into Product Development provides a comprehensive understanding of the role of biological sciences, specifically in transforming technology into commercial product. This book compiles the theoretical and practical aspects of bioentrepreneurship and discusses the various factors, including creating business plans, acquiring funding, and successful business models. The chapters also cover areas such as small-scale product development, intellectual property rights, funding schemes for start-ups, and new prospective biotechnology product development. This book is essential for bioentrepreneurs, entrepreneurs, product developers, scientists, practitioners, researchers, academicians, and students interested in product development from a biological science perspective.

Encyclopedia of Tissue Engineering and Regenerative Medicine

Encyclopedia of Tissue Engineering and Regenerative Medicine Book
Author : Anonim
Publisher : Academic Press
Release : 2019-06-03
ISBN : 0128137002
Language : En, Es, Fr & De

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Book Description :

Encyclopedia of Tissue Engineering and Regenerative Medicine provides a comprehensive collection of personal overviews on the latest developments and likely future directions in the field. By providing concise expositions on a broad range of topics, this encyclopedia is an excellent resource. Tissue engineering and regenerative medicine are relatively new fields still in their early stages of development, yet they already show great promise. This encyclopedia brings together foundational content and hot topics in both disciplines into a comprehensive resource, allowing deeper interdisciplinary research and conclusions to be drawn from two increasingly connected areas of biomedicine. Provides a ‘one-stop’ resource for access to information written by world-leading scholars in the fields of tissue engineering and regenerative medicine Contains multimedia features, including hyperlinked references and further readings, cross-references and diagrams/images Represents the most comprehensive and exhaustive product on the market on the topic

Sabiston Textbook of Surgery E Book

Sabiston Textbook of Surgery E Book Book
Author : Courtney M. Townsend
Publisher : Elsevier Health Sciences
Release : 2021-01-08
ISBN : 0323640648
Language : En, Es, Fr & De

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Book Description :

For more than 80 years, Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice has been the go-to text for trainees and surgeons at all levels of experience for definitive guidance on every aspect of general surgery. As the oldest continuously published textbook of surgery in North America, this fully revised 21st Edition continues to provide the key information, essential teaching pearls, and completely updated content needed to make the most informed surgical decisions and achieve optimal outcomes for patients. Concisely written and evidence based throughout, it covers the breadth of material required for certification and practice of general surgery, highlighted by detailed, full-color intraoperative illustrations and high-quality video clips. Follows a clear, consistent progression beginning with principles common to surgical specialties including fluid and electrolyte management, metabolic support, and wound healing. Subsequent sections review the management of injury, transplantation, oncology, breast, endocrine, and abdominal procedures. Covers key topics such as emerging surgical technologies and devices, regenerative medicine, the latest concepts in cancer biology and treatments, and evidence-based management and treatment. Emphasizes the most up-to-date minimally invasive techniques and the use of robotics when indicated. Features more than 2,000 superb illustrations and intraoperative photographs and 25 procedural videos that facilitate quick comprehension of surgical techniques. Includes more schematic diagrams, summary tables, boxes, and algorithms that provide a rich resource for reviewing surgical techniques and preparing for in-training and board exams. Shares the expertise of dozens of new authors and includes two new chapters on robotic surgery and fetal surgery. Contains fully updated content on topics encountered by general surgery residents in training as well as in-depth coverage of subspecialty areas including head and neck, thoracic, vascular, urology, neurosurgery, pediatrics, and gynecology.

Cardiac Bioelectric Therapy

Cardiac Bioelectric Therapy Book
Author : Igor R. Efimov,Fu Siong Ng,Jacob I. Laughner
Publisher : Springer Nature
Release : 2021-01-28
ISBN : 3030633551
Language : En, Es, Fr & De

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Book Description :

The updated and expanded second edition of this book presents a contemporary review of the basic science, engineering technology, and clinical practice of cardiac bioelectric therapy. It covers the rapidly expanding technological development of pacemakers and defibrillators as well as ablative therapy, electrophysiological mapping, and other clinical diagnostic and therapeutic breakthroughs. The book highlights many different aspects of bioelectric therapy, including history, biophysical and computational concepts, basic electrophysiology studies, engineering technology advances, and clinical perspectives. In this revised edition, leading clinical and basic electrophysiologists share their perspectives on the science behind the mechanisms of cardiac arrhythmias; breakthrough technologies for scientific and clinical investigation of heart rhythm disorders; theoretical conceptualization of arrhythmias and treatment using state-of-the-art computational approaches; and novel approaches to treatment of cardiac arrhythmias using implantable devices, percutaneous ablation therapies, machine learning, and other approaches. The Second Edition of Cardiac Bioelectric Therapy is an essential resource for physicians, residents, fellows, and graduate students in clinical cardiac electrophysiology, cardiology, and cardiac surgery as well as researchers, professionals, and students in biomedical, mechanical, and electrical engineering.

Pharmacology and Physiology for Anesthesia E Book

Pharmacology and Physiology for Anesthesia E Book Book
Author : Hugh C. Hemmings,Talmage D. Egan
Publisher : Elsevier Health Sciences
Release : 2018-10-19
ISBN : 0323568866
Language : En, Es, Fr & De

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Book Description :

Pharmacology and physiology are the foundation of every anesthesia provider’s training and clinical competency. Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application, 2nd Edition, delivers the information you need in pharmacology, physiology, and molecular-cellular biology, keeping you current with contemporary training and practice. This thoroughly updated edition is your one-stop, comprehensive overview of physiology, and rational anesthetic drug selection and administration, perfect for study, review, and successful practice. Contains new chapters on Special Populations (anesthetic pharmacology in obesity, geriatrics, and pediatrics), Oral and Non-IV Opioids, Thermoregulation, Physiology and Pharmacology of Obstetric Anesthesia, Chemotherapeutic and Immunosuppresive Drugs, and Surgical Infection and Antimicrobial Drugs. Incorporates entirely new sections on Physics, Anatomy, and Imaging. Includes new information on consciousness and cognition, pharmacodynamics, the immune system, and anti-inflammatory drugs. Features user-friendly tables, figures, and algorithms (including 100 new illustrations), all presented in full color and designed to help explain complex concepts. Helps you understand the molecular mechanism of drug actions and identify key drug interactions that may complicate anesthesia with dedicated sections on these areas.