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Crispr Genome Surgery In Stem Cells And Disease Tissues

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CRISPR Genome Surgery in Stem Cells and Disease Tissues

CRISPR Genome Surgery in Stem Cells and Disease Tissues Book
Author : Stephen H. Tsang
Publisher : Elsevier
Release : 2021-10-29
ISBN : 0128178760
Language : En, Es, Fr & De

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Book Description :

CRISPR Genome Surgery in Stem Cells and Disease Tissues focuses uniquely on the clinical applications of CRISPR/Cas9 based technology. Topics include the latest advances in gene editing and its translational applications to various diseases, including retinal degenerative disease, recessively inherited diseases, and dominantly inherited diseases, to name a few. The book's target audience includes researchers, students, clinicians and the general public. This space that is not currently served by any existing resource, so this publication fills a gap in current literature. Provides a thorough review of CRISPR-Cas9, from discovery to therapy Covers the latest advances in gene editing and its translational applications to various diseases Written by global leaders in the fields of gene editing and stem cell therapy

CRISPR Genome Surgery in Stem Cells and Disease Tissues

CRISPR Genome Surgery in Stem Cells and Disease Tissues Book
Author : Stephen H. Tsang
Publisher : Academic Press
Release : 2021-10-20
ISBN : 0128178779
Language : En, Es, Fr & De

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Book Description :

CRISPR Genome Surgery in Stem Cells and Disease Tissues focuses uniquely on the clinical applications of CRISPR/Cas9 based technology. Topics include the latest advances in gene editing and its translational applications to various diseases, including retinal degenerative disease, recessively inherited diseases, and dominantly inherited diseases, to name a few. The book's target audience includes researchers, students, clinicians and the general public. This space that is not currently served by any existing resource, so this publication fills a gap in current literature. Provides a thorough review of CRISPR-Cas9, from discovery to therapy Covers the latest advances in gene editing and its translational applications to various diseases Written by global leaders in the fields of gene editing and stem cell therapy

Success in Academic Surgery Basic Science

Success in Academic Surgery  Basic Science Book
Author : Gregory Kennedy,Ankush Gosain,Melina Kibbe,Scott A. LeMaire
Publisher : Springer
Release : 2019-04-29
ISBN : 3030146448
Language : En, Es, Fr & De

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Book Description :

This updated volume provides the foundation for starting a basic science research career as an academic surgeon. Taking a practical approach, the book covers the suggested timeline for the initial academic appointment, including how to setup and fund the laboratory and identifying appropriate scientific mentors and lab personnel. It also describes the application of basic and advanced research techniques, including animal models, flow cytometry, gene editing, tissue engineering, and microbiome analysis. Success in Academic Surgery: Basic Science aims to give guidance on the application of basic and advanced techniques in surgical research. This book is relevant to senior residents and fellows approaching their first academic appointment, as well as more senior investigators interested in expanding their research horizons.

Proceedings of 7th International Conference and Exhibition on Cell and Gene Therapy 2018

Proceedings of 7th International Conference and Exhibition on Cell and Gene Therapy 2018 Book
Author : ConferenceSeries
Publisher : ConferenceSeries
Release : 2022-08-13
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

March 15-16, 2018 London,UK Key Topics : Stem Cell Therapies, Cell Culture and Bioprocessing, Viral Gene Therapy, Gene and Cell Therapy for Rare & Common Diseases, Tissue Science & Regenerative Medicine, Molecular Basis of Epigenetics, Clinical Trials on Cell & Gene Therapy, Cell Science and Stem Cell Research, Bioengineering Therapeutics, Nano Therapy, Gene Editing Technology, Advanced Gene Therapeutics, Genetics & Genomic Medicine, Ethical Issues in Cell and Gene Therapy, Markets & Future Prospects for Cell & Gene Therapy, Cell Therapy, Gene Therapy, Cell Therapy of Cardiovascular Disorders, Cell Therapy for Neurological Disorders, Regulatory and Safety Aspects of Cell and Gene Therapy, Commercialization,

CRISPR Cas Systems

CRISPR Cas Systems Book
Author : Rodolphe Barrangou,John van der Oost
Publisher : Springer Science & Business Media
Release : 2012-12-13
ISBN : 364234657X
Language : En, Es, Fr & De

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Book Description :

CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

Plastic Surgery Principles and Practice E Book

Plastic Surgery   Principles and Practice E Book Book
Author : Rostam Farhadieh,Neil Bulstrode,Babak J. Mehrara,Sabrina Cugno
Publisher : Elsevier Health Sciences
Release : 2021-04-22
ISBN : 0323653820
Language : En, Es, Fr & De

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Book Description :

With detailed, expert guidance on each essential topic, Plastic Surgery: Principles and Practice offers single-volume convenience without sacrificing complete coverage of this multi-faceted field. Written by global leading authorities, it provides concise, easy-to-follow instruction with the clinical details and supportive data needed to achieve optimal patient outcomes. Offers thorough coverage of facelift procedures, rhinoplasty, otoplasty and more, along with clinical pearls from masters in the field. Features hundreds of high-quality images including anatomical line art, case photos, and procedural operative photos. I Includes a superb selection of procedural videos of global experts performing key techniques within operating room and close-up clinical pearls. An ideal resource for residents, fellows, and practitioners in plastic surgery, as well as those in otolaryngology, vascular surgery, and cosmetic dermatology.

Precision Medicine CRISPR and Genome Engineering

Precision Medicine  CRISPR  and Genome Engineering Book
Author : Stephen H. Tsang
Publisher : Springer
Release : 2017-11-11
ISBN : 3319639048
Language : En, Es, Fr & De

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Book Description :

This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine. Chapters feature contributions from leaders in stem cell therapy and biology, providing a comprehensive view of the application of gene therapy in numerous fields with an emphasis on ophthalmology, stem cells, and agriculture. The book also highlights recent major technological advances, including ZFN, TALEN, and CRISPR. Precision Medicine, CRISPR, and Genome Engineering is part of the highly successful Advances in Experimental Medicine and Biology series. It is an indispensable resource for researchers and students in genetics as well as clinicians.

Genome Engineering via CRISPR Cas9 System

Genome Engineering via CRISPR Cas9 System Book
Author : Vijai Singh,Pawan K. Dhar
Publisher : Academic Press
Release : 2020-02-18
ISBN : 0128181419
Language : En, Es, Fr & De

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Book Description :

Genome Engineering via CRISPR-Cas9 Systems presents a compilation of chapters from eminent scientists from across the globe who have established expertise in working with CRISPR-Cas9 systems. Currently, targeted genome engineering is a key technology for basic science, biomedical and industrial applications due to the relative simplicity to which they can be designed, used and applied. However, it is not easy to find relevant information gathered in a single source. The book contains a wide range of applications of CRISPR in research of bacteria, virus, algae, plant and mammalian and also discusses the modeling of drosophila, zebra fish and protozoan, among others. Other topics covered include diagnosis, sensor and therapeutic applications, as well as ethical and regulatory issues. This book is a valuable source not only for beginners in genome engineering, but also researchers, clinicians, stakeholders, policy makers, and practitioners interested in the potential of CRISPR-Cas9 in several fields. Provides basic understanding and a clear picture on how to design, use and implement the CRISPR-Cas9 system in different organisms Explains how to create an animal model for disease research and screening purposes using CRISPR Discusses the application of CRISPR-Cas9 systems in basic sciences, biomedicine, virology, bacteriology, molecular biology, neurology, cancer, industry, and many more

Human Genome Editing

Human Genome Editing Book
Author : National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Publisher : National Academies Press
Release : 2017-08-13
ISBN : 0309452880
Language : En, Es, Fr & De

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Book Description :

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Retinal Degenerative Diseases

Retinal Degenerative Diseases Book
Author : Matthew M. LaVail,John Ash,Robert E. Anderson,Joe G. Hollyfield,Christian Grimm
Publisher : Springer Science & Business Media
Release : 2011-12-21
ISBN : 1461406315
Language : En, Es, Fr & De

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Book Description :

This book will contain the proceedings of the XIV International Symposium on Retinal Degeneration (RD2010), held July 13-17, 2010, in Mont-Tremblant, Quebec, Canada. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.

Cells Are the New Cure

Cells Are the New Cure Book
Author : Robin L. Smith
Publisher : BenBella Books
Release : 2017-10-24
ISBN : 1944648844
Language : En, Es, Fr & De

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Book Description :

The future of medicine is happening now. Revolutionary new science is providing cures that were considered science fiction just a few years ago—and not with pills, surgery, or radiation, but with human cells. Promising treatments now in extensive clinical trials could have dramatic impacts on cancer, autoimmune diseases, organ replacement, heart disease, and even aging itself. The key to these breakthroughs is the use of living cells as medicine instead of traditional drugs. Discover the advances that are alleviating the effects of strokes, Alzheimer's disease, and even allergies. Cells Are the New Cure takes you into the world of regenerative medicine, which enables doctors to repair injured and aging tissues and even create artificial body parts and organs in the lab. Cellular medicine experts Robin L. Smith, MD, and Max Gomez, PhD, outline the new technologies that make it possible to harness the immune system to fight cancer and reverse autoimmune diseases like multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. CRISPR, a new technology for targeted gene editing, promises to eradicate genetic diseases, allowing us to live longer lives—possibly even beyond age 100 in good health. Cells Are the New Cure takes you on a tour of the most exciting and cutting-edge developments in medicine. The content inside these pages could save your life or the life of someone you love.

Gene Therapy for Cancer

Gene Therapy for Cancer Book
Author : Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher
Publisher : Springer Science & Business Media
Release : 2007-10-26
ISBN : 159745222X
Language : En, Es, Fr & De

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Book Description :

The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

CRISPR Cas Enzymes

CRISPR Cas Enzymes Book
Author : Anonim
Publisher : Academic Press
Release : 2019-01-25
ISBN : 0128167610
Language : En, Es, Fr & De

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Book Description :

CRISPR-Cas Enzymes, Volume 616, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Topics covered in this release include CRISPR bioinformatics, A method for one-step assembly of Class 2 CRISPR arrays, Biochemical reconstitution and structural analysis of ribonucleoprotein complexes in Type I-E CRISPR-Cas systems, Mechanistic dissection of the CRISPR interference pathway in Type I-E CRISPR-Cas system, Site-specific fluorescent labeling of individual proteins within CRISPR complexes, Fluorescence-based methods for measuring target interference by CRISPR-Cas systems, Native State Structural Characterization of CRISRP Associated Complexes using Mass Spectrometry, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Updated release includes the latest information on the CRISPR-Cas Enzymes

Stem Cells for Cancer and Genetic Disease Treatment

Stem Cells for Cancer and Genetic Disease Treatment Book
Author : Phuc Van Pham,Ahmed El-Hashash
Publisher : Springer
Release : 2018-11-07
ISBN : 3319980653
Language : En, Es, Fr & De

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Book Description :

This invaluable resource discusses insights ranging from basic biological mechanisms of various types of stem cells through the potential applications in the treatment of human diseases, including cancer and genetic disorders. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in understanding different types of stem cell biology and their potential applications in tissue repair and regeneration and in the treatment different types of human cancer and genetic diseases or disorders. Stem Cells for Cancer and Genetic Disease Treatment and the other books in the Stem Cells in Clinical Applicationsseries will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering as well as cancer or genetics research.

Heritable Human Genome Editing

Heritable Human Genome Editing Book
Author : The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Publisher : National Academies Press
Release : 2021-01-16
ISBN : 0309671132
Language : En, Es, Fr & De

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Book Description :

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

A Guide to Human Gene Therapy

A Guide to Human Gene Therapy Book
Author : Roland W. Herzog,Sergei Zolotukhin
Publisher : World Scientific
Release : 2010
ISBN : 9814280917
Language : En, Es, Fr & De

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Book Description :

Ever since the birth of molecular biology, the tantalizing possibility of treating disease at its genetic roots has become increasingly feasible. Gene therapy - though still in its infancy - remains one of the hottest areas of research in medicine. Its approach utilizes a gene transfer vehicle ( vector) to deliver therapeutic DNA or RNA to cells of the body in order to rectify the defect that is causing the disease. Successful therapies have been reported in humans in recent years such as cures in boys with severe immune deficiencies. Moreover, gene therapy strategies are being adapted in numerous biomedical laboratories to obtain novel treatments for a variety of diseases and to study basic biological aspects of disease. Correction of disease in animal studies, is steadily gaining ground, highlighting the immense potential of gene therapy in the medical profession. This book will cover topics that are at the forefront of biomedical research such as RNA interference, viral and non-viral gene transfer systems, treatment of hematological diseases and disorders of the central nervous system.Leading experts on the respective vector or disease will contribute the individual chapters and explain cutting-edge technologies. It also gives a broad overview of the most important gene transfer vectors and most extensively studied target diseases. This comprehensive guide is therefore a must-read for anyone in the biotechnology, biomedical or medical industries seeking to further their knowledge in the area of human gene therapy.

Genome Editing and Engineering

Genome Editing and Engineering Book
Author : Krishnarao Appasani
Publisher : Cambridge University Press
Release : 2018-07-31
ISBN : 1107170370
Language : En, Es, Fr & De

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Book Description :

A complete guide to endonuclease-based genomic engineering, from basic science to application in disease biology and clinical treatment.

Gene Therapy in Reconstructive and Regenerative Surgery

Gene Therapy in Reconstructive and Regenerative Surgery Book
Author : Giorgio Giatsidis
Publisher : Springer
Release : 2018-08-02
ISBN : 3319789570
Language : En, Es, Fr & De

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Book Description :

This book offers an updated overview of the most recent research advances in the field, a comparison of established techniques and methods, a discussion on current experimental and translational challenges, and a commentary on potential opportunities and future directions. Dedicated chapters address and review the preclinical and clinical state-of-the-art of gene therapies for the reconstructive and regenerative surgery of skin and wounds, pathological scars, cartilage, tendons, skeletal muscles, and bio-engineered flaps. A brief guide to developing gene therapy clinical trials in the context of reconstructive and regenerative surgery is also provided. Biomedical and technological innovations are transforming our capacity to use gene therapies to safely and effectively repair, reconstruct, and regenerate tissues that are deficient or have been damaged by trauma and diseases. The targeted and controlled modulation of gene expression in tissues represents a game-changing, next-generation therapeutic tool for the modern reconstructive surgeon, expanding the horizon of regenerative surgery and tissue engineering. Through gene therapies, surgeons can direct (stem) cell differentiation and cell function, modulate the release of growth/transcriptional factors, affect the biological properties of regenerative scaffolds, control tissue inflammation, or induce immune-suppression in composite tissue allotransplants and xenotransplants. Written by renowned reconstructive surgeons and leading experts in each of these fields - from top academic institutions around the globe, the book provides an initial practical guide for veteran and newcomer surgeons alike, as well as for researchers interested in exploring the latest gene-based therapeutic strategies for reconstructive and regenerative surgery.

Stem Cells and Regenerative Medicine

Stem Cells and Regenerative Medicine Book
Author : Walter C. Low,Catherine M. Verfaillie
Publisher : World Scientific
Release : 2008
ISBN : 9812775773
Language : En, Es, Fr & De

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Book Description :

The commercialization of biotechnology has resulted in an intensive search for new biological resources for the purposes of increasing food productivity, medicinal applications, energy production, and various other applications. Although biotechnology has produced many benefits for humanity, the exploitation of the planet's natural resources has also resulted in some undesirable consequences such as diminished species biodiversity, climate change, environmental contamination, and intellectual property right and patent concerns.This book discusses the role of biological, ecological, environmental, ethical, and economic issues in the interaction between biotechnology and biodiversity, using different contexts. No other book has discussed all of these issues in a comprehensive manner. Of special interest is their impact when biotechnology is shared between developed and developing countries, and the lack of recognition of the rights of indigenous populations and traditional farmers in developing countries by large multinational corporations.

Regulation of Intestinal Stem Cell Niche and Colon Cancer

Regulation of Intestinal Stem Cell Niche and Colon Cancer Book
Author : Kuei-Ling Tung
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The intestine is one of the fastest regenerative tissues in the body, and homeostasis of the tissue requires robust regulations of intra- and inter-cellular signaling. The stem cells reside at crypt bottom of intestinal epithelium serve as the workhorse of tissue regeneration and keep the tissue homeostasis. When dysregulated events occur to normal intestine cells, cancerous cells often emerge with unchecked cell growth and perturbed cell death, and escape from rigorous mechanisms of cellular signaling regulations. Colorectal cancer (CRC) is one of the most common cause of cancer deaths. Current treatments include surgery and chemotherapy, but disease recurrence occurs frequently. The continuous renewal of intestinal epithelium relies on the presence of intestinal stem cells that could be at the origin of CRC and contribute to therapy resistance and metastases. Several cell signaling pathways and regulatory elements involve in both intestinal cell homeostasis and tumorigenesis. My studies focus on understanding the regulation in intestinal stem cell niche and applying transcriptome and chromatin accessibility profiling to investigate drug resistance in colon cancer. Tissue homeostasis requires rigorous control mechanisms for stem cell division and maintenance of a stable stem cell niche. In the intestinal stem cell (ISC) niche, ISCs and Paneth cells form a stable pattern to control stem cell behavior. However, how is the stem cell niche pattern dynamically regulated and maintained in a rapid regenerative environment still remains unclear. We stimulated intestinal organoids with Notch ligands and inhibitors and discovered that intestinal stem cells employ a positive feedback mechanism via direct Notch binding to the second intron of the Notch1 gene. Inactivation of the positive feedback by CRISPR/Cas9 mutation of the binding sequence alters the mosaic stem cell niche pattern and hinders regeneration in organoids. This study highlights the importance of Notch 1 positive feedback mechanisms in spatiotemporal control of the stem cell niche. Patients with advanced colorectal cancer (CRC) develop chemoresistance to current standard-of-care therapies. We used patient-derived organoids (PDO) from metastatic CRC patients and integrated chromatin and transcriptomic profiling to show that resistant tumor cells remodel their chromatin in response to chemotherapy. Personalized therapy with pharmacological inhibitor of FGFR1 or OXTR, two novel targets for resistant CRC, circumvents oxaliplatin resistance. This study demonstrates the combination of PDO and integrated chromatin/transcriptomic analysis as a potential precision medicine platform to overcome chemoresistance.