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Crispr Genome Surgery In Stem Cells And Disease Tissues

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CRISPR Genome Surgery in Stem Cells and Disease Tissues

CRISPR Genome Surgery in Stem Cells and Disease Tissues Book
Author : Stephen H. Tsang
Publisher : Academic Press
Release : 2021-05-01
ISBN : 0128178779
Language : En, Es, Fr & De

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Book Description :

CRISPR Genome Surgery in Stem Cells and Disease Tissues focuses uniquely on the clinical applications of CRISPR/Cas9 based technology. Topics include the latest advances in gene editing and its translational applications to various diseases, including retinal degenerative disease, recessively inherited diseases, and dominantly inherited diseases, to name a few. The book's target audience includes researchers, students, clinicians and the general public. This space that is not currently served by any existing resource, so this publication fills a gap in current literature. Provides a thorough review of CRISPR-Cas9, from discovery to therapy Covers the latest advances in gene editing and its translational applications to various diseases Written by global leaders in the fields of gene editing and stem cell therapy

Stem Cells for Cancer and Genetic Disease Treatment

Stem Cells for Cancer and Genetic Disease Treatment Book
Author : Phuc Van Pham,Ahmed El-Hashash
Publisher : Springer
Release : 2018-11-07
ISBN : 3319980653
Language : En, Es, Fr & De

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Book Description :

This invaluable resource discusses insights ranging from basic biological mechanisms of various types of stem cells through the potential applications in the treatment of human diseases, including cancer and genetic disorders. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in understanding different types of stem cell biology and their potential applications in tissue repair and regeneration and in the treatment different types of human cancer and genetic diseases or disorders. Stem Cells for Cancer and Genetic Disease Treatment and the other books in the Stem Cells in Clinical Applicationsseries will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering as well as cancer or genetics research.

Plastic Surgery Principles and Practice E Book

Plastic Surgery   Principles and Practice E Book Book
Author : Rostam Farhadieh,Neil Bulstrode,Babak J. Mehrara,Sabrina Cugno
Publisher : Elsevier Health Sciences
Release : 2021-04-22
ISBN : 0323653820
Language : En, Es, Fr & De

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Book Description :

With detailed, expert guidance on each essential topic, Plastic Surgery: Principles and Practice offers single-volume convenience without sacrificing complete coverage of this multi-faceted field. Written by global leading authorities, it provides concise, easy-to-follow instruction with the clinical details and supportive data needed to achieve optimal patient outcomes. Offers thorough coverage of facelift procedures, rhinoplasty, otoplasty and more, along with clinical pearls from masters in the field. Features hundreds of high-quality images including anatomical line art, case photos, and procedural operative photos. I Includes a superb selection of procedural videos of global experts performing key techniques within operating room and close-up clinical pearls. An ideal resource for residents, fellows, and practitioners in plastic surgery, as well as those in otolaryngology, vascular surgery, and cosmetic dermatology.

Corneal Regeneration

Corneal Regeneration Book
Author : Jorge L. Alió,Jorge L. Alió del Barrio,Francisco Arnalich-Montiel
Publisher : Springer
Release : 2019-02-20
ISBN : 3030013049
Language : En, Es, Fr & De

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Book Description :

This text provides expert instruction on the varying surgical techniques currently employed for the regeneration of the ocular surface. Corneal Regeneration: Therapy and Surgery begins with a thorough discussion of current research based on data obtained in clinical human studies, and discusses the potential clinical implications for this promising new stage of eye surgery. Sections devoted to the stem cell, regenerative surgery and therapy of the ocular surface epithelium, corneal stroma, and corneal endothelium follow, each section comprehensively covering applied anatomy, current therapy and regenerative techniques, with a look to future directions of the field including eventual cell therapy. Corneal Regeneration: Therapy and Surgery is the first book of its kind, systematically covering the developments the medical community has achieved in corneal regeneration from all angles. Written and edited by leading experts in the field, researchers and ophthalmologists alike will find this to be a unique source of information on corneal regeneration, as well as a thoughtful reflection on potential applications of regenerative surgery in ophthalmology as a whole.

The Columbia Guide to Basic Elements of Eye Care

The Columbia Guide to Basic Elements of Eye Care Book
Author : Daniel S. Casper,George A. Cioffi
Publisher : Springer
Release : 2019-07-01
ISBN : 3030108864
Language : En, Es, Fr & De

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Book Description :

This unique resource is a practical, easy-to-use guide for the non-ophthalmologist healthcare provider as they encounter patients with eye complaints and other concerning ophthalmic conditions. The Columbia Guide to Basic Elements of Eye Care is specifically designed with the non-ophthalmologist in mind, and provides a foundation of basic eye anatomy and physiology, functional analysis, pathology, and concepts in eye care. Each chapter delivers an accessible summary of various ophthalmic diseases and conditions, all of which are frequently encountered in everyday practice. These chapters provide in-depth discussions on a wide range of topics, from testing and examination procedures to management protocols, referral guidelines and expected frequency of follow-up for each disorder. Complete with hundreds of high-quality, descriptive illustrations and clinical photographs, The Columbia Guide to Basic Elements of Eye Care presents clear, understandable explanations of basic eye anatomy, physiology, disease and treatment for non-ophthalmic practitioners and students. In doing so, this guide provides a framework for determining the normal versus the abnormal, helping the reader recognize which patients require referral, and identify which conditions are developing, require urgent treatment, or can be routinely followed. Non-ophthalmologist healthcare providers and students alike will find this book, written by leaders in the field, a practical resource to consult as they encounter patients with treatable but potentially sight-threatening conditions.

Genome Editing and Engineering

Genome Editing and Engineering Book
Author : Krishnarao Appasani
Publisher : Cambridge University Press
Release : 2018-07-31
ISBN : 1107170370
Language : En, Es, Fr & De

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Book Description :

A complete guide to endonuclease-based genomic engineering, from basic science to application in disease biology and clinical treatment.

Crohn s Disease and Ulcerative Colitis

Crohn s Disease and Ulcerative Colitis Book
Author : Daniel C. Baumgart
Publisher : Springer
Release : 2017-03-01
ISBN : 3319337033
Language : En, Es, Fr & De

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Book Description :

This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field. Written by experts in their field, Crohn’s Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis, and related autoimmune disorders.

SCHWARTZ S PRINCIPLES OF SURGERY 2 volume set 11th edition

SCHWARTZ S PRINCIPLES OF SURGERY 2 volume set 11th edition Book
Author : F. Charles Brunicardi,Dana K. Andersen,Timothy R. Billiar,David L. Dunn,John G. Hunter,Lillian Kao,Jeffrey B. Matthews,Raphael E. Pollock
Publisher : McGraw Hill Professional
Release : 2019-05-29
ISBN : 1259835375
Language : En, Es, Fr & De

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Book Description :

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The BEST EDITION yet of the #1 text for surgical practice and education For half-a-century, no other text has provided such a solid grounding in basic science, anatomy, operative techniques, and more recently, professional development and leadership training, as Schwartz’s Principles of Surgery. Written by the world’s foremost surgeons, this landmark reference offers distinctly modern and all-encompassing coverage of every important topic in general surgery. Enhanced by a new two volume presentation, the Eleventh Edition has been completely updated and refreshed with an emphasis on state-of-the-art, evidence-based surgical care. You will find an exciting array of new contributors from around the world, new chapters on cutting-edge topics, plus the acclaimed learning aids that make the material easier to understand and memorize. This outstanding content is bolstered by more than 800 photographs and 1,300 line drawings, most in full color, as well as online videos demonstrating key operations. Here’s why the Eleventh Edition is the best edition yet: Six timely new chapters on important topics such as enhanced recovery after surgery (ERAS), ambulatory/outpatient surgery, evidence for surgery practice, skills and simulation, and web-based education and social media High-quality full-color design showcases an unsurpassed illustration program Emphasis on high-yield discussion of diagnosis and treatment of surgical disease, arranged by organ system and surgical specialty Acclaimed learning aids (many new to this edition), including an abundance of completely up-to-date tables that summarize the most current evidence, boxed key points, detailed anatomical figures, diagnostic and management algorithms, and an abundance of completely up-to-date tables, and key references More than the field’s cornerstone textbook, Schwartz’s Principles of Surgery is an international compendium of the knowledge and technique of the world’s leading surgeons.

Regulation of Intestinal Stem Cell Niche and Colon Cancer

Regulation of Intestinal Stem Cell Niche and Colon Cancer Book
Author : Kuei-Ling Tung
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The intestine is one of the fastest regenerative tissues in the body, and homeostasis of the tissue requires robust regulations of intra- and inter-cellular signaling. The stem cells reside at crypt bottom of intestinal epithelium serve as the workhorse of tissue regeneration and keep the tissue homeostasis. When dysregulated events occur to normal intestine cells, cancerous cells often emerge with unchecked cell growth and perturbed cell death, and escape from rigorous mechanisms of cellular signaling regulations. Colorectal cancer (CRC) is one of the most common cause of cancer deaths. Current treatments include surgery and chemotherapy, but disease recurrence occurs frequently. The continuous renewal of intestinal epithelium relies on the presence of intestinal stem cells that could be at the origin of CRC and contribute to therapy resistance and metastases. Several cell signaling pathways and regulatory elements involve in both intestinal cell homeostasis and tumorigenesis. My studies focus on understanding the regulation in intestinal stem cell niche and applying transcriptome and chromatin accessibility profiling to investigate drug resistance in colon cancer. Tissue homeostasis requires rigorous control mechanisms for stem cell division and maintenance of a stable stem cell niche. In the intestinal stem cell (ISC) niche, ISCs and Paneth cells form a stable pattern to control stem cell behavior. However, how is the stem cell niche pattern dynamically regulated and maintained in a rapid regenerative environment still remains unclear. We stimulated intestinal organoids with Notch ligands and inhibitors and discovered that intestinal stem cells employ a positive feedback mechanism via direct Notch binding to the second intron of the Notch1 gene. Inactivation of the positive feedback by CRISPR/Cas9 mutation of the binding sequence alters the mosaic stem cell niche pattern and hinders regeneration in organoids. This study highlights the importance of Notch 1 positive feedback mechanisms in spatiotemporal control of the stem cell niche. Patients with advanced colorectal cancer (CRC) develop chemoresistance to current standard-of-care therapies. We used patient-derived organoids (PDO) from metastatic CRC patients and integrated chromatin and transcriptomic profiling to show that resistant tumor cells remodel their chromatin in response to chemotherapy. Personalized therapy with pharmacological inhibitor of FGFR1 or OXTR, two novel targets for resistant CRC, circumvents oxaliplatin resistance. This study demonstrates the combination of PDO and integrated chromatin/transcriptomic analysis as a potential precision medicine platform to overcome chemoresistance.

Cells Are the New Cure

Cells Are the New Cure Book
Author : Robin L. Smith, MD,Max Gomez, PhD
Publisher : BenBella Books
Release : 2017-10-24
ISBN : 1944648844
Language : En, Es, Fr & De

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Book Description :

The future of medicine is happening now. Revolutionary new science is providing cures that were considered science fiction just a few years ago—and not with pills, surgery, or radiation, but with human cells. Promising treatments now in extensive clinical trials could have dramatic impacts on cancer, autoimmune diseases, organ replacement, heart disease, and even aging itself. The key to these breakthroughs is the use of living cells as medicine instead of traditional drugs. Discover the advances that are alleviating the effects of strokes, Alzheimer’s disease, and even allergies. Cells Are the New Cure takes you into the world of regenerative medicine, which enables doctors to repair injured and aging tissues and even create artificial body parts and organs in the lab. Cellular medicine experts Robin L. Smith, MD, and Max Gomez, PhD, outline the new technologies that make it possible to harness the immune system to fight cancer and reverse autoimmune diseases like multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. CRISPR, a new technology for targeted gene editing, promises to eradicate genetic diseases, allowing us to live longer lives—possibly even beyond age 100 in good health. Cells Are the New Cure takes you on a tour of the most exciting and cutting-edge developments in medicine. The content inside these pages could save your life or the life of someone you love.

Issues in Life Sciences Cellular Biology 2011 Edition

Issues in Life Sciences  Cellular Biology  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 146496386X
Language : En, Es, Fr & De

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Book Description :

Issues in Life Sciences: Cellular Biology / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Life Sciences—Cellular Biology. The editors have built Issues in Life Sciences: Cellular Biology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Life Sciences—Cellular Biology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Life Sciences: Cellular Biology: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Williams Hematology 10th Edition

Williams Hematology  10th Edition Book
Author : Kenneth Kaushansky,Marshall A. Lichtman,Josef T. Prchal,Marcel M. Levi,Linda J. Burns
Publisher : McGraw Hill Professional
Release : 2021-01-14
ISBN : 126046413X
Language : En, Es, Fr & De

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Book Description :

The landmark text that has guided generations of hematologists and related practitioners―updated with the latest research findings and improved format and presentation Long revered for its comprehensiveness and extraordinary depth of detail, Williams Hematology provides essential coverage of the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood and marrow cells and coagulation proteins. The text contains a wealth of basic science and translational pathophysiology for optimal, lifelong learning. Experts in research and clinical hematology, the editors are known worldwide for their contributions to the field. This new edition contains everything that has made Williams Hematology the go-to resource for decades and has been updated with new chapters and critical new research into the molecular mechanisms responsible for hematological disorders and the impact on diagnosis and treatment. And the new format enables you to access each chapter via content modules covering key topics, with summaries, infographics, and cases―all linked to review questions for self-assessment. The full-color presentation integrates images of blood and tissue findings where they are cited in the text. NEW TO THIS EDITION: Updated and revised content reflecting the latest research and developments Convenient format that streamlines the learning process and improves retention Additional chapters added on: Immune Checkpoint Inhibitors Immune Cell Therapy: Chimeric Antigen Receptor T Cell Therapy Immune Cell Therapy Dendritic Cell and Natural Killer Cell Therapy The processes of cell death and survival Application of Big Data and Deep Learning in Hematology Williams Hematology Cases with multiple-choice questions including detailed explanations—perfect preparation for the boards Continuously updated online content with comprehensive drug therapy database and other resources

Issues in Biological and Life Sciences Research 2011 Edition

Issues in Biological and Life Sciences Research  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464963355
Language : En, Es, Fr & De

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Book Description :

Issues in Biological and Life Sciences Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biological and Life Sciences Research. The editors have built Issues in Biological and Life Sciences Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biological and Life Sciences Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biological and Life Sciences Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.