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Coronavirus Drug Discovery

Coronavirus Drug Discovery Book
Author : Chukwuebuka Egbuna
Publisher : Elsevier
Release : 2021-02-15
ISBN : 9780323851565
Language : En, Es, Fr & De

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Book Description :

Coronavirus Drug Discovery: SARS-CoV-2 (Covid 19) Prevention, Diagnosis, and Treatment presents comprehensive information on antiviral drug discovery from medicinal plants, animals, marine organisms and microorganisms. This book present special chapters on the COVID-19 disease outbreak and detailed information on drug discovery for the COVID-19 virus, including its diagnosis and prevention strategies. Subsequent chapters present drug discovery opportunities for the treatment and management of respiratory viral diseases, gastrointestinal viral diseases, exanthematous viral diseases, hepatic viral diseases, cutaneous viral diseases, hemorrhagic viral diseases and neurologic viral diseases. The book's contributors are specialists from key institutions around the world, making this a key resource for drug developers, medicinal chemists, public health scientists, molecular biologists, biochemists, and toxicologists, among others. Details the various natural bioactive compounds for antiviral drug discoveries surrounding treatments for the coronavirus Discuses recent drug discovery for covid-19 treatment and drug discovery from natural sources Focuses on the discovery of drugs against acute viral diseases of world importance Reviews recent advances in research tools for the discovery of new antiviral drugs

Novel Coronavirus 2019

Novel Coronavirus 2019 Book
Author : Amit Kumar
Publisher : Springer Nature
Release : 2021-04-10
ISBN : 9811579180
Language : En, Es, Fr & De

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Book Description :

Download Novel Coronavirus 2019 book written by Amit Kumar, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Influenza Virus Sialidase A Drug Discovery Target

Influenza Virus Sialidase   A Drug Discovery Target Book
Author : Mark Itzstein
Publisher : Springer Science & Business Media
Release : 2011-09-01
ISBN : 9783764389277
Language : En, Es, Fr & De

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Book Description :

Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge. This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented. These include a full coverage of the design, synthesis and evaluation of carbohydrate as well as non-carbohydrate influenza virus sialidase inhibitors. Further reviews of the clinical experience with influenza virus sialidase inhibitors and of the development of resistance to these inhibitor drugs complement the topic.

Delving Into Dengue Virus Drug Discovery

Delving Into Dengue Virus Drug Discovery Book
Author : Nomagugu Belinda Ncube
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Delving Into Dengue Virus Drug Discovery book written by Nomagugu Belinda Ncube, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats

Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats Book
Author : Paul F. Torrence
Publisher : John Wiley & Sons
Release : 2005-08-05
ISBN : 0471716707
Language : En, Es, Fr & De

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Book Description :

Antiviral Drug Discovery gives readers a cutting-edge view of how chemical concepts are being mobilized to develop novel approaches that will effectively confront emerging diseases and biowarfare. Among the many topics discussed are smallpox, the Ebola virus, influenza, SARS, arenaviruses and flaviviruses. Each chapter discusses hypothetical strategies for the discovery of relevant antiviral agents, recent findings related to biochemistry or drug discovery, and advances in the further development of established leads in the area. Timely and informative, this book clearly delineates the efforts being made to develop new and effective broad-spectrum antiviral agents.

Biomedical Index to PHS supported Research

Biomedical Index to PHS supported Research Book
Author : Anonim
Publisher : Unknown
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Protein Interactions As Targets in Drug Discovery

Protein Interactions As Targets in Drug Discovery Book
Author : Rossen Donev
Publisher : Academic Press
Release : 2020-05
ISBN : 0128168463
Language : En, Es, Fr & De

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Book Description :

Protein Interactions as Targets in Drug Discovery, Volume 121, is dedicated to the design of therapeutics, both experimental and computational, that target protein interactions. Chapters in this new release include Trends in structure based drug design with protein targets, From fragment- to peptide-protein interaction: addressing the structural basis of binding using Supervised Molecular Dynamics (SuMD), Protein-protein and protein-ligand interactions: identification of potential inhibitors through computational analysis, Aromatic-aromatic interactions in protein-drug and protein-protein interactions, Role of protein-protein interaction in allosteric drug design within the human methyltransferome, and much more.

Neglected Tropical Diseases

Neglected Tropical Diseases Book
Author : David C. Swinney,Michael P. Pollastri
Publisher : John Wiley & Sons
Release : 2019-09-30
ISBN : 3527343040
Language : En, Es, Fr & De

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Book Description :

A drug discovery reference to the crippling tropical diseases that affect more than 1 billion people. Neglected Tropical Diseases is the first book of its kind to offer a guide that follows the World Health Organization?s list of neglected tropical diseases. The authors?all are experts on the topic?address the development of effective treatments for 12 crippling infectious diseases that affect almost 20% of the world?s popluation. The book includes information on the common approaches and the most important factors that lead to the development of new drugs for treating tropical diseases. Individual chapters review 12 neglected tropical diseases that are grouped by infectious agent, from viruses to bacteria to eukaryotic parasites. For each of these diseases, the book explains the unmet medical need and explores the current and potential drug discovery strategies. The book also includes information on potential drug compounds derived from natural products. This important book: -Ties together information from different sources for developing novel treatsments forneglected tropical diseases -Is aligned with WHO?s initiative to eradicate tropical diseases -Outlines current and potential drugs for treating tropical diseases -Provides a standard reference for the entire field Written for medicinal chemists, pharmaceutical chemists, pharmaceutical industry, virologists, parasitologists, and specialists on tropics medicine, Neglected Tropical Diseases offers an essential guide and a systematic reference for the development of successful treatments for 12 crippling infectious diseases.

Drug Discovery Handbook

Drug Discovery Handbook Book
Author : Shayne C. Gad
Publisher : Wiley-Interscience
Release : 2005-07-11
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

THE FIRST COMPREHENSIVE GUIDE TO THE METHODS AND TECHNIQUES OF DRUG DISCOVERY The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs. This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systems biology Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more Specific approaches to drug discovery, including problems that are encountered, solutions to these problems, and limitations of various methods and techniques The thorough coverage and practical, scientifically valid problem-solving approach of Drug Discovery Handbook will serve as an invaluable aid in the complex task of developing new drugs.

Burger s Medicinal Chemistry and Drug Discovery Therapeutic agents

Burger s Medicinal Chemistry and Drug Discovery  Therapeutic agents Book
Author : Alfred Burger
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Burger s Medicinal Chemistry and Drug Discovery Therapeutic agents book written by Alfred Burger, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Zika Virus Surveillance Vaccinology and Anti Zika Drug Discovery

Zika Virus Surveillance  Vaccinology  and Anti Zika Drug Discovery Book
Author : Subhash C. Basak,Ashesh Nandy
Publisher : Unknown
Release : 2019-03-15
ISBN : 9781536149708
Language : En, Es, Fr & De

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Book Description :

The bubonic plague, smallpox, HIV/AIDS, malaria, and influenza are some of the worst epidemics/pandemics that afflicted human beings from antiquity to modern times, killing millions of people. The mosquito-borne human-infecting viruses, rotavirus, and the seasonal influenza regularly affect lives across continents in the millions. Currently, we are facing various disease-inducing organisms of the Flavivirus family the Yellow fever virus (YFV), West Nile virus (WNV), Japanese encephalitis virus (JEV), Tick-borne encephalitis virus (TBEV), Dengue virus (DENV) and Zika virus (ZIKV). Zika virus was first isolated from a febrile rhesus monkey in the Zika forest of Uganda in 1947. It drew out heightened attention following the large number of microcephaly in newborn babies in Latin America in 2015. On 1 February 2016, WHO declared that the association of Zika infection with clusters of microcephaly and other neurological disorders constituted a Public Health Emergency of International Concern. Although the severity and number of ZIKV afflicted cases have gone down lately, the public health community worldwide is keeping a watchful eye on it. ZIKV is an enveloped virus with a positive-sense RNA genome that translates into a single polypeptide, which then gets cleaved into three structural and seven nonstructural viral proteins. As compared to the earlier centuries, we have an expanding repertoire of diverse and fast acting technologies available at our hand to manage and mitigate emerging diseases. Completion of the Human Genome Project has given rise to sequencing methods which can quickly determine the genetic sequence of an alarming pathogen. Following Moores law, the power of computers, essential for data analysis and visualization, has grown substantially with time. The combination of genomic data of pathogens, computational modeling methods, and data driven methodologies can lead to a generic approach of surveillance, mitigation, vaccine design as well as new drug discovery for emerging pathogens. The four pillars of this may consist of: a) Epidemiological approaches for the characterization of carriers of next possible emerging pathogens; b) Fast computational sequence comparison methods for the characterization of emerging pathogens to understand how novel or severe they could be; c) Once the sequences of the pathogen have been determined, computer-aided vaccine design (CAVD) methods can be used to suggest a set of probable vaccine candidates for quick synthesis and testing in the laboratory; and d) Computer-assisted design of novel therapeutics and their laboratory testing as well as repurposing of already existing FDA-approved drugs. A combination of different classes of methods in vivo, in vitro and in silico will be needed to tackle suddenly emerging viruses like the Zika virus. As in many other fields of biomedical research, high throughput and low cost in silico technologies may provide the first line of defense against such emerging pathogens providing decision support systems for the judicious applications of medium throughput in vitro methods and low throughput as well as costly in vivo techniques. An emerging trend in many scientific disciplines is a strong tendency of being transformed into some form of information science. The editors of this book sincerely hope that the four-pronged computer-assisted approach described in this book will help in managing and mitigating emerging infectious diseases like Zika.

Medicinal Chemistry and Drug Discovery Chemotherapeutic agents

Medicinal Chemistry and Drug Discovery  Chemotherapeutic agents Book
Author : Alfred Burger
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Medicinal Chemistry and Drug Discovery Chemotherapeutic agents book written by Alfred Burger, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Medicinal Chemistry and Drug Discovery Nervous system agents

Medicinal Chemistry and Drug Discovery  Nervous system agents Book
Author : Alfred Burger
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Medicinal Chemistry and Drug Discovery Nervous system agents book written by Alfred Burger, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Successful Strategies for the Discovery of Antiviral Drugs

Successful Strategies for the Discovery of Antiviral Drugs Book
Author : Manoj C. Desai,Nicholas A. Meanwell,David E. Thurston
Publisher : Royal Society of Chemistry
Release : 2013
ISBN : 184973657X
Language : En, Es, Fr & De

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Book Description :

A volume that will be aimed at medicinal chemistry and emerging drug discovery scientists. The book will be organized according to the various strategies deployed for the discovery and optimization of initial lead compounds. It will be broken down into four main sections: phenotypic and biochemical screening, structure and physical property-based drug design and delivery of antiviral agents. Each chapter will provide an in depth view of the development of leads and drug candidates in specific areas of contemporary antiviral drug discovery, capturing molecules that have been in advanced phases of clinical investigation. The focus of the book will be on capturing tactical aspects of problem solving in antiviral drug design, an approach that will hold special appeal for those engaged in antiviral drug development but will also appeal to the broader chemistry community based on its focus on tactical aspects of drug design.

Innovative Approaches in Drug Research

Innovative Approaches in Drug Research Book
Author : A. F. Harms
Publisher : Elsevier Publishing Company
Release : 1986
ISBN : 9780444426062
Language : En, Es, Fr & De

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Book Description :

Download Innovative Approaches in Drug Research book written by A. F. Harms, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Burger s Medicinal Chemistry and Drug Discovery Drug Discovery

Burger s Medicinal Chemistry and Drug Discovery  Drug Discovery Book
Author : Donald J. Abraham
Publisher : Wiley-Interscience
Release : 2003
ISBN : 9780471270904
Language : En, Es, Fr & De

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Book Description :

This is Volume 1: Drug Discovery, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Virtual Screening, Bioinformatics and Chemical Information Computing Systems in Drug Discovery. To purchase the entire 6 volume set, please refer to ISBN 0-471-37032-0. For a complete list of articles and contributors as well as FREE sample chapters from this new 6th Edition please visit: www.mrw.interscience.wiley.com/bmcdd

Carbohydrate based Drug Discovery 2 Volume Set

Carbohydrate based Drug Discovery  2 Volume Set Book
Author : Chi-Huey Wong
Publisher : Wiley-VCH
Release : 2003-10-17
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.

Human Immunodeficiency Virus Epidemic

Human Immunodeficiency Virus Epidemic Book
Author : Presidential Commission
Publisher : Unknown
Release : 1988
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Drug Screening Methods

Drug Screening Methods Book
Author : S. K. Gupta
Publisher : Anshan Pub
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Drug discovery and development is a challenging, expensive and time consuming field of research, requiring contributions from chemists, pharmacologists, toxicologists, clinicians, and practitioners. The ultimate goal is to generate a safe and biologically active drug which can stall, or even reverse, the pathological events that cause the disease condition. But in the search for the drug a host of tests and trials must be applied to evaluate the efficiency and safety of the newly developed molecule in the biological system. These trials or "screening methods" are critical. On their basis, the new molecule either becomes accepted for usage, or is discarded forever. Advances in drug research have forced the need for quicker, more automated screening methods, using molecular techniques applied in vitro, in vivo and in clinical systems. Researchers need to know the latest developments outside their own speciality. With this book, Professor Gupta has brought together in one coherent volume the most up to date developments of consolidated screening methods for biological systems. By paying attention to the practical techniques used in academia and the commercial pharmaceutical industry, "Drug Screening Methods" will enjoy a broad readership, serving both the professional community and the student of pharmacology.

Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America Book
Author : National Academy of Sciences (U.S.)
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Proceedings of the National Academy of Sciences of the United States of America book written by National Academy of Sciences (U.S.), available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.