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Conn s Translational Neuroscience

Conn s Translational Neuroscience Book
Author : P. Michael Conn
Publisher : Academic Press
Release : 2016-09-28
ISBN : 0128025964
Language : En, Es, Fr & De

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Book Description :

Conn’s Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn’s Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance Features contributions from leading global basic and clinical investigators in the field Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes Relates and translates the current science to the understanding of neurological disorders and their treatment

Functional and Clinical Neuroanatomy

Functional and Clinical Neuroanatomy Book
Author : Jahangir Moini,Pirouz Piran
Publisher : Academic Press
Release : 2020-02-21
ISBN : 0128174250
Language : En, Es, Fr & De

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Book Description :

Functional and Clinical Neuroanatomy: A Guide for Health Care Professionals is a comprehensive, yet easy-to read, introduction to neuroanatomy that covers the structures and functions of the central, peripheral and autonomic nervous systems. The book also focuses on the clinical presentation of disease processes involving specific structures. It is the first review of clinical neuroanatomy that is written specifically for nurses, physician assistants, nurse practitioners, medical students and medical assistants who work in the field of neurology. It will also be an invaluable resource for graduate and postgraduate students in neuroscience. With 22 chapters, including two that provide complete neurological examinations and diagnostic evaluations, this book is an ideal resource for health care professionals across a wide variety of disciplines. Written specifically for "mid-level" providers in the field of neurology Provides an up-to-date review of clinical neuroanatomy based on the latest guidelines Provides a logical, step-by-step introduction to neuroanatomy Offers hundreds of full-color figures to illustrate important concepts Highlights key subjects in "Focus On" boxes Includes Section Reviews at critical points in the text of each chapter

The American Society of Addiction Medicine Handbook on Pain and Addiction

The American Society of Addiction Medicine Handbook on Pain and Addiction Book
Author : Ilene Robeck,Melvin Pohl,Michael Weaver,Mark Weiner,Herbert Malinoff,Cory Waller,William Haning
Publisher : Oxford University Press
Release : 2018-03-15
ISBN : 0190265388
Language : En, Es, Fr & De

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Book Description :

The American Society of Addiction Medicine Handbook on Pain and Addiction provides clinical considerations and guidelines for the clinician treating patients with pain and addiction. Produced by the largest medical society dedicated to the improvement of addiction care, the book takes an evidence-based approach and uses articles from both the literature and well-regarded organizations and government agencies including NIDA, CDC, SAMHSA, PCSS-O, and ASAM itself. The ASAM Handbook is structured in five sections that cover the core concepts of addressing pain and addiction; diagnosis and treatment; treating pain in patients with, or at risk for, co-occuring addiction; treating substance use disorders (SUD) and addiction in patients with co-occuring pain; and adapting treatment to the needs of specific populations. Each chapter ends with suggestions for further reading on the topics discussed. This book is ideal for primary care providers, mental health clinicians, SUD clinicians, and pain clinicians who wish to bridge the knowledge gaps related to treating patients with pain and addiction. To learn more about the American Society of Addiction Medicine, and its commitment to providing the best resources for addiction clinicians, please visit http://www.asam.org.

PCR in Neuroscience

PCR in Neuroscience Book
Author : Anonim
Publisher : Elsevier
Release : 1995-04-13
ISBN : 9780080536453
Language : En, Es, Fr & De

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Book Description :

The volumes in this series include contemporary techniques significant to a particular branch of neuroscience. They are an invaluable aid to the student as well as the experienced researcher not only in developing protocols in neuroscience but in disciplines where research is becoming closely related to neuroscience. Each volume of Methods in Neurosciences contains an index, and each chapter includes references. Dr. Conn became Editor-in-Chief of the series beginning with Volume 15, so each subsequent volume could be guest-edited by an expert in that specific field. This further strengthens the depth of coverage in Methods in Neurosciences for students and researchers alike. Direct application of PCR to fresh or frozen clinical specimens (e.g., blood and solid tissue) Complete retrieval of novel expressed genes by PCR without screening a library Quantitation by PCR Mutagenesis by PCR PCR in AIDS research Simple and effective protocols for PCR on archival specimens

Neuroimmunology

Neuroimmunology Book
Author : Anonim
Publisher : Academic Press
Release : 1995-03-01
ISBN : 9780080536439
Language : En, Es, Fr & De

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Book Description :

The volumes in this series include contemporary techniques significant to a particular branch of neuroscience. They are an invaluable aid to the student as well as the experienced researcher not only in developing protocols in neuroscience but in disciplines where research is becoming closely related to neuroscience. Each volume of Methods in Neurosciences contains an index, and each chapter includes references. Dr. Conn became Editor-in-Chief of the series beginning with Volume 15, so each subsequent volume could be guest-edited by an expert in that specific field. This further strengthens the depth of coverage in Methods in Neurosciences for students and researchers alike. Comprehensive protocols included for the study of: The brain-immune system The neuroimmune system: Effects of the brain on the peripheral immune system Neuroimmune effects from substances of abuse (e.g. cocaine) to hypnosis Measurement of interferons, cytokines, natural killer cells, and major histocompatibility complex molecules Immunohistochemistry methods in the brain Neuropeptides as immunomodulators

Receptor Molecular Biology

Receptor Molecular Biology Book
Author : Anonim
Publisher : Elsevier
Release : 1995-03-22
ISBN : 9780080536446
Language : En, Es, Fr & De

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Book Description :

The volumes in this series include contemporary techniques significant to a particular branch of neuroscience. They are an invaluable aid to the student as well as the experienced researcher not only in developing protocols in neuroscience but in disciplines where research is becoming closely related to neuroscience. Each volume of Methods in Neurosciences contains an index, and each chapter includes references. Dr. Conn became Editor-in-Chief of the series beginning with Volume 15, so each subsequent volume could be guest-edited by an expert in that specific field. This further strengthens the depth of coverage in Methods in Neurosciences for students and researchers alike. Cloning Expression systems Signal transduction Structure-function techniques Antireceptor antibodies Regulation 3-D receptor modeling and computational probing

Harrison s Principles of Internal Medicine 20 E Vol 1 Vol 2 ebook

Harrison s Principles of Internal Medicine 20 E  Vol 1   Vol 2   ebook  Book
Author : Dennis L. Kasper,Anthony S. Fauci,Stephen L. Hauser,Dan L. Longo,J. Larry Jameson,Joseph Loscalzo
Publisher : McGraw Hill Professional
Release : 2018-02-06
ISBN : 1259644049
Language : En, Es, Fr & De

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Book Description :

MASTER MODERN MEDICINE! Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible. Essential for practice and education, the landmark 20th Edition features: Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care. State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals. All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine— Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine. Important and timely new chapters—such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more—offer the very latest, definitive perspectives on must-know topics in medical education and practice. Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes. End-of-chapter suggested readings reinforce the text material and provide a robust platform for further study and research.

Computers and Computations in the Neurosciences

Computers and Computations in the Neurosciences Book
Author : P. Michael Conn
Publisher : Academic Press
Release : 2013-10-22
ISBN : 148325951X
Language : En, Es, Fr & De

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Book Description :

Methods in Neurosciences, Volume 10: Computers and Computations in the Neurosciences discusses the use of computers in the neurosciences. The book deals with data collection, analysis, and modeling, with emphasis on the use of computers. Section I involves data collection using a personal microcomputer system. One paper presents a tutorial on using a PC-based motor control composed of an electronic circuit to adjust the motion of a light microscope stage through a software program. Other papers discuss computer methods in nuclei cartography and a computer-assisted quantitative receptor autoradiography in studying receptor density distribution. Section II deals with data analysis and some computer programs for kinetic modeling of gene expression in neurons. The book also discusses a computerized analysis of opioid receptor heterogeneity by ligand binding in test animals using computerized programs instead of employing manual or graphical methods. Computerized curve-fitting allows the researcher to utilize a more precise mathematical model to describe the binding of one ligand to one class of sites. Section III evaluates data modeling and simulations and describes the practicality of using computers to design model ion channels. Another paper discusses a graphical interaction program called MEMPOT to simulate an electrophysiological investigation of the properties of the membrane potential in stimulated cells. The book also presents a quantitative data gathered from computer simulation of the factors that affect neuronal density per measured sections. The book is suitable for microbiologists, biochemists, neuroscientists, and researchers in the field of medical research, as well as for advanced computer programmers in medical research work.

Methods in Neurosciences

Methods in Neurosciences Book
Author : P. Michael Conn
Publisher : Elsevier
Release : 2016-07-02
ISBN : 1483284921
Language : En, Es, Fr & De

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Book Description :

Because of the significance of morphology and cellular communication unique to the functioning and interdependence of neural systems, many of the advances in the neurosciences rely on classic as well as new microscopy techniques. A convenient bench-top format**Methods presented for easy adaptation to new systems**Comprehensive protocols included for**Autoradiography: measurement of hormone receptors, high-resolution techniques, double labeling and combined techniques**Statistical and computational methods: video imaging, three-dimensional reconstructions, means of structural quantitation, unbiased sampling methods, measurement of analysis of neuronal connections, staining, and individual axon arbors**Tracing neuronal connections: tracer, toxin, and dye methods**Staining techniques: fluoro-gold, SITS, and silver impregnation**Freezing techniques: freeze fracture and cryoprotection**Combined and high-resolution techniques: double-label tracer techniques, incident light polarization, light and electron microscopic techniques

Neurotoxins

Neurotoxins Book
Author : P. Michael Conn
Publisher : Academic Press
Release : 2013-10-22
ISBN : 1483284883
Language : En, Es, Fr & De

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Book Description :

The exquisite simplicity and potency of toxins have made them valuable probes of neural systems. This book presents a comprehensive compilation of techniques used for the preparation, handling, and, particularly, for the use of neurotoxins. Model systems are described in which these neurotoxins have been extremely valuable in developing an understanding of the cellular and molecular basis of secretion and electrophysiological events leading to altered cell function. Convenient benchtop format Methods presented for easy adaptation to new systems A virtual "A-B-C" of commonly used and available toxins Comprehensive protocols included for the use of alpha toxin, apamin, batrachotoxin; botulina toxin, bungarotoxin; channel ligands: agonists and antagonists; capsaicin; charybdotoxin, ciguatoxin; Clostridium botulinum neurotoxin; cholera toxin (choleragen); conotoxin; dendrotoxin; endothelin; fasciculin; geographutoxin; latrotoxin; natural toxins; neosurgatoxin; palytoxin; pertussis toxin; resiniferatoxin; sarafotoxin; scorpion toxin; snake venom toxins

Molecular Biology of Protein Folding

Molecular Biology of Protein Folding Book
Author : P. Michael Conn
Publisher : Academic Press
Release : 2008-12-19
ISBN : 9780080923383
Language : En, Es, Fr & De

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Book Description :

The importance of protein folding has been recognized for many years. It is the underlying etiology in a large number of human diseases and it appears to be a novel method for cellular regulation of the expression of newly translated proteins. These volumes (Parts A & B) address this important topic. As a volume in Progress in Nucleic Acid Research and Molecular Biology, this book provides the latest information on the expanding research being conducted on protein folding. *Follow the new editor-in-chief, P. Michael Conn, as he introduces this first thematic volume in the series – an in-depth aid to researchers who are looking for the best techniques and tools for understanding the complexities of protein folding *Understand the advantages of protein folding over other therapeutic approaches and see how protein folding plays a critical role in the development of diseases such as Alzheimer’s and diabetes *Decipher the rules of protein folding through compelling and timely reviews combined with chapters written by international authors in engineering, biochemistry, physics and computer science

Neurobiology of Cytokines

Neurobiology of Cytokines Book
Author : Errol B. DeSouza
Publisher : Academic Press
Release : 2013-10-22
ISBN : 1483288315
Language : En, Es, Fr & De

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Book Description :

Recent data suggest a critical role for cytokines in the regulation of brain and endocrine function under normal physiological conditions. The aim of this volume and its companion Volume 16 is to provide an overview of the effects of cytokines in the brain and in the endocrine system. Methods presented for easy adaptation to new systems Comprehensive protocols included for: The synthesis and release of cytokines; The study of their central nervous system actions; Studying the role of cytokines in human neuropathological conditions

Conn s Handbook of Models for Human Aging

Conn s Handbook of Models for Human Aging Book
Author : Jeffrey L. Ram,P. Michael Conn
Publisher : Academic Press
Release : 2018-04-05
ISBN : 0128113545
Language : En, Es, Fr & De

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Book Description :

Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students. Combines both the methods of study for human aging and animal models Provides a historical overview and discussion of model availability, key methods and ethical issues Contains over 200 full color illustrations

Quantitative Neuroendocrinology

Quantitative Neuroendocrinology Book
Author : Anonim
Publisher : Elsevier
Release : 1995-10-16
ISBN : 9780080536477
Language : En, Es, Fr & De

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Book Description :

In this volume contemporary methods designed to provide insights into, mathematical structure for, and predictive inferences about neuroendocrine control mechanisms are presented. Collates an array of contemporary techniques for analysis of neuroendocrine data Discusses current problems in and solutions to neurohormone pulse analysis Identifies relevant software available

Laser Capture in Microscopy and Microdissection

Laser Capture in Microscopy and Microdissection Book
Author : Anonim
Publisher : Elsevier
Release : 2002-11-01
ISBN : 0080497012
Language : En, Es, Fr & De

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Book Description :

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today—truly an essential publication for researchers in all fields of life sciences. Basic Principles, Specialized Uses, and Genetic Applications LCM and its application in genomics and proteomics Fluorescence in situ hybridization of LCM isolated nuclei from paraffin sections Noncontact laser catapulting for the functional genomics and proteomics Use of LCM for clonal analysis, in carcinoma analysis, to assess development, in complex tissue, in pathology, gene discovery, and more

Ion Channels Part B

Ion Channels  Part B Book
Author : John N. Abelson,Bernardo Rudy,P. Michael Conn,Linda E. Iverson,Melvin I. Simon
Publisher : Academic Press
Release : 1998-08-14
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This volume plus its companion, Volume 294, presents cutting edge techniques for the study of ion channels, ranging from the molecular to the physiological level. These volumes supplement Volume 207 of Methods inEnzymology Key Features * Assembly * Genetics * Electrophysiology * Expression Systems * Model Simulations

Gene Probes

Gene Probes Book
Author : P. Michael Conn
Publisher : Academic Press
Release : 2014-04-24
ISBN : 1483267857
Language : En, Es, Fr & De

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Book Description :

Methods in Neurosciences, Volume 1: Gene Probes is a compendium of papers that deals with the developments in molecular biology, cell biology, and electrophysiology. Section I deals with gene expression using the Xenopus Oocyte system for expression and cloning of neuroreceptors and channels. One paper presents a method in studying the molecules in the brain related to neurotransmitter receptors and to the voltage channels in the brain by ""transplanting"" functional neurotransmitter receptors into the membrane of frog oocytes. Section II describes in situ and solution hybridization and the continuation of in situ hybridization with immunohistochemistry. One paper discusses the benefits of using alkaline phosphatase-Dig-dUTP-labeled oligonucleotide probes in high-resolution in situ in terms of ease of performance, safety, and fast detection rendering. Section III addresses the screening, sequencing, and cloning, the process of which includes the rapid identification of DNA clones. One paper outlines the methods and materials that are used in such identification. Section IV explains lineage analysis and Section V discusses molecular pathology, including the molecular pathology of Alzheimer's disease. This collection can prove useful for geneticists, molecular scientists, and academicians involved in neuroscience and pharmacological sciences, as well as researchers in geriatrics.

Imaging in Biological Research

Imaging in Biological Research Book
Author : P. Michael Conn
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Imaging in Biological Research book written by P. Michael Conn, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Hormone Action Part K Neuroendocrine Peptides

Hormone Action  Part K  Neuroendocrine Peptides Book
Author : P. Michael Conn
Publisher : Academic Press
Release : 1989-04-11
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Volume 168 of Methods in Enzymology will prove invaluable not only to those in the field but also to those in related disciplines who find their studies becoming closely linked to the neurosciences. Methodologies are presented to allow easy adaptation to new systems and to stress their general applicability and potential limitations.

Hormone Action Part K Neuroendocrine Peptides

Hormone Action  Part K  Neuroendocrine Peptides Book
Author : P. Michael Conn
Publisher : Academic Press
Release : 1989-04-11
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Volume 168 of Methods in Enzymology will prove invaluable not only to those in the field but also to those in related disciplines who find their studies becoming closely linked to the neurosciences. Methodologies are presented to allow easy adaptation to new systems and to stress their general applicability and potential limitations.