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Conn s Translational Neuroscience

Conn s Translational Neuroscience Book
Author : P. Michael Conn
Publisher : Academic Press
Release : 2016-09-28
ISBN : 0128025964
Language : En, Es, Fr & De

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Book Description :

Conn’s Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn’s Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance Features contributions from leading global basic and clinical investigators in the field Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes Relates and translates the current science to the understanding of neurological disorders and their treatment

Arachnoid Cysts

Arachnoid Cysts Book
Author : Knut Wester
Publisher : Academic Press
Release : 2017-10-20
ISBN : 9780128143780
Language : En, Es, Fr & De

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Book Description :

Arachnoid Cysts: Clinical and Surgical Management gives a broad and updated presentation of the condition, including symptomatology, diagnostics, management and treatment. The book covers the effects of surgical treatment on clinical symptoms and the effects cysts have on cognition, as well as cognitive improvement after surgical cyst decompression. This book is written for researchers, residents and clinical practitioners in clinical neuroscience, neurology, neurosurgery, neuroradiology and pediatrics. Covers the symptomology and treatment of arachnoid cysts Describes impaired cognition associated with arachnoid cysts Identifies the advantages, disadvantages and results of different surgical approaches Provides valuable information to researchers, residents and clinical practitioners in clinical neuroscience, neurology, neurosurgery, neuroradiology and pediatrics

Functional and Clinical Neuroanatomy

Functional and Clinical Neuroanatomy Book
Author : Jahangir Moini,Pirouz Piran
Publisher : Academic Press
Release : 2020-02-21
ISBN : 0128174250
Language : En, Es, Fr & De

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Book Description :

Functional and Clinical Neuroanatomy: A Guide for Health Care Professionals is a comprehensive, yet easy-to read, introduction to neuroanatomy that covers the structures and functions of the central, peripheral and autonomic nervous systems. The book also focuses on the clinical presentation of disease processes involving specific structures. It is the first review of clinical neuroanatomy that is written specifically for nurses, physician assistants, nurse practitioners, medical students and medical assistants who work in the field of neurology. It will also be an invaluable resource for graduate and postgraduate students in neuroscience. With 22 chapters, including two that provide complete neurological examinations and diagnostic evaluations, this book is an ideal resource for health care professionals across a wide variety of disciplines. Written specifically for "mid-level" providers in the field of neurology Provides an up-to-date review of clinical neuroanatomy based on the latest guidelines Provides a logical, step-by-step introduction to neuroanatomy Offers hundreds of full-color figures to illustrate important concepts Highlights key subjects in "Focus On" boxes Includes Section Reviews at critical points in the text of each chapter

Harrison s Principles of Internal Medicine 20 E Vol 1 Vol 2 ebook

Harrison s Principles of Internal Medicine 20 E  Vol 1   Vol 2   ebook  Book
Author : Dennis L. Kasper,Anthony S. Fauci,Stephen L. Hauser,Dan L. Longo,J. Larry Jameson,Joseph Loscalzo
Publisher : McGraw Hill Professional
Release : 2018-02-06
ISBN : 1259644049
Language : En, Es, Fr & De

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Book Description :

MASTER MODERN MEDICINE! Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible. Essential for practice and education, the landmark 20th Edition features: Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care. State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals. All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine— Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine. Important and timely new chapters—such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more—offer the very latest, definitive perspectives on must-know topics in medical education and practice. Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes. End-of-chapter suggested readings reinforce the text material and provide a robust platform for further study and research.

Neuroimmunology

Neuroimmunology Book
Author : Anonim
Publisher : Academic Press
Release : 1995-03-01
ISBN : 9780080536439
Language : En, Es, Fr & De

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Book Description :

The volumes in this series include contemporary techniques significant to a particular branch of neuroscience. They are an invaluable aid to the student as well as the experienced researcher not only in developing protocols in neuroscience but in disciplines where research is becoming closely related to neuroscience. Each volume of Methods in Neurosciences contains an index, and each chapter includes references. Dr. Conn became Editor-in-Chief of the series beginning with Volume 15, so each subsequent volume could be guest-edited by an expert in that specific field. This further strengthens the depth of coverage in Methods in Neurosciences for students and researchers alike. Comprehensive protocols included for the study of: The brain-immune system The neuroimmune system: Effects of the brain on the peripheral immune system Neuroimmune effects from substances of abuse (e.g. cocaine) to hypnosis Measurement of interferons, cytokines, natural killer cells, and major histocompatibility complex molecules Immunohistochemistry methods in the brain Neuropeptides as immunomodulators

Conn s Handbook of Models for Human Aging

Conn s Handbook of Models for Human Aging Book
Author : Jeffrey L. Ram,P. Michael Conn
Publisher : Academic Press
Release : 2018-04-05
ISBN : 0128113545
Language : En, Es, Fr & De

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Book Description :

Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students. Combines both the methods of study for human aging and animal models Provides a historical overview and discussion of model availability, key methods and ethical issues Contains over 200 full color illustrations

Electrophysiology and Microinjection

Electrophysiology and Microinjection Book
Author : P. Michael Conn
Publisher : Elsevier
Release : 2016-07-02
ISBN : 1483284891
Language : En, Es, Fr & De

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Book Description :

Electrical activity is central to the functioning and nature of neural cells. Every effort has been made in this volume to provide representative examples of useful techniques that have made this area a productive component of the neurosciences. Convenient bench-top format**Methods presented for easy adaptation to new systems**Comprehensive protocols included for**Cell recording: from conscious and freely behaving animals, measurement of calcium currents, and multiple electrodes**Voltage clamping and voltammetry: apparatus and applications**Specific ion channels and receptors: expression in oocytes, single-cell secretion, purification of calcium channel drug receptors**Special electrodes and other equipment: movable electrodes, microelectrodes, multiple electrodes, en passant recording, microincubators for optical studies**Special preparations: multicompartment cell cultures, grease-gap methods, perforated path techniques, giant proteoliposomes for reconstitution studies, microinjection**Data analysis and reduction: digital filtering on a personal computer, filtering on a personal computer, fitting of single-channel dwell time distributions, discrimination of kinetic models, voltage noise analysis, list-oriented analysis of single-channel systems

Neurobiology of Cytokines

Neurobiology of Cytokines Book
Author : Errol B. DeSouza
Publisher : Academic Press
Release : 2013-10-22
ISBN : 1483288315
Language : En, Es, Fr & De

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Book Description :

Recent data suggest a critical role for cytokines in the regulation of brain and endocrine function under normal physiological conditions. The aim of this volume and its companion Volume 16 is to provide an overview of the effects of cytokines in the brain and in the endocrine system. Methods presented for easy adaptation to new systems Comprehensive protocols included for: The synthesis and release of cytokines; The study of their central nervous system actions; Studying the role of cytokines in human neuropathological conditions

Neurobiology of Steroids

Neurobiology of Steroids Book
Author : E. Ronald de Kloet
Publisher : Academic Press
Release : 2013-10-22
ISBN : 1483288366
Language : En, Es, Fr & De

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Book Description :

Steroid hormones are unique compounds in that they are active at the interface of peripheral endocrine events and neural mechanisms. Thus their effects present an important peripheral signaling system to alter brain function. This volume presents state-of-the-art and classical techniques for the study of steroid hormones and their receptors and their effects and actions. Comprehensive protocols included for the study of Steroid kinetics and metabolism Steroid receptors Molecular and cellular effects of steroids Steroid effects on integrated systems

Providing Pharmacological Access to the Brain

Providing Pharmacological Access to the Brain Book
Author : Thomas R. Flanagan
Publisher : Academic Press
Release : 2013-10-22
ISBN : 1483288358
Language : En, Es, Fr & De

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Book Description :

This volume focuses on contemporary approaches for delivering experimental and therapeutic agents into the brain. The contributions provide methodological details that are typically not available in the literature. Subtleties and shortcuts critical to each procedure are included to facilitate their use by both the experienced researcher and novice. Highlights * Polymeric, cellular, and molecular drug delivery * Neuropharmacology * Blood-brain barrier * Central nervous system

Measurement and Manipulation of Intracellular Ions

Measurement and Manipulation of Intracellular Ions Book
Author : Anonim
Publisher : Academic Press
Release : 1995-10-10
ISBN : 0080536468
Language : En, Es, Fr & De

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Book Description :

This practical book provides the detailed methodology and expert guidance required for measuring and manipulating cytosolic ion concentrations. In addition, the strengths, weaknesses, and pitfalls of various techniques are presented. It is an invaluable source for those needing an objective evaluation of current methodologies and for those contemplating setting up such procedures. Key Features * A one-source reference for measuring and manipulating intracellular ions and for comparing and evaluating current methodologies * Includes overviews of * Optical probes and reagents * Fabrication and use of ion-selective microelectrodes * Use of NMR spectroscopy * Ionophores

Lipid Metabolism in Signaling Systems

Lipid Metabolism in Signaling Systems Book
Author : John N. Fain
Publisher : Academic Press
Release : 2013-10-22
ISBN : 1483288323
Language : En, Es, Fr & De

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Book Description :

Many of the phospholipases and even the receptor for inositol 1,4,5-trisphosphate have recently been cloned and sequenced and play an important role in neurotransmission. Methods developed in recent years for the study of the enzymes and intermediates involved in the regulation of neuronal signal transduction involving phospholipid turnover are presented in this volume. Techniques for examining the role of phosphoinositides in signal transduction Techniques related to protein kinase C Analysis of inositol phosphates Techniques to analyze phospholipid turnover in the brain

Ion Channels of Excitable Cells

Ion Channels of Excitable Cells Book
Author : Toshio Narahashi
Publisher : Academic Press
Release : 2013-10-22
ISBN : 1483288331
Language : En, Es, Fr & De

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Book Description :

Because of the highly significant and widely recognized roles of ion channels in physiology, pathophysiology, pharmacology, and toxicology, the term ion channel has now become a household word in the biomedical sciences. This volume covers preparations and techniques for the study of various ion channels. Both voltage-gated and ligand-gated ion channels of neurons, axons, and cardiac and smooth muscles are covered. It includes not only patch clamp techniques but molecular biology and imaging techniques as well. Comprehensive protocols included for the study of: Ion channels using patch-clamp, molecular biology, and imaging techniques Role of ion channels in physiology, pathophysiology, pharmacology, and toxicology Specific ion channels of specific tissues

The Receptors

The Receptors Book
Author : P. Michael Conn
Publisher : Academic Press
Release : 2014-05-10
ISBN : 1483273687
Language : En, Es, Fr & De

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Book Description :

The Receptors, Volume II deals with receptors for somatostatin, vitamin D, insulin, and animal viruses, as well as for the ?2-adrenergic and Ah systems. The significance of translational modifications of receptor ligands is discussed, along with the mechanisms of receptor-ligand interactions. The role of receptors in development and their regulation by tumors are also considered. Comprised of 12 chapters, this volume begins with a detailed account of the vitamin D receptor, paying particular attention to its biochemical and physical properties as well as its mechanism of action. The discussion then turns to experimental discrimination between alternative mechanistic models for the receptor-mediated stimulation of adenylate cyclase; the role of microaggregation in hormone-receptor-effector interactions; and the biology and biochemistry of the Ah receptor. Subsequent chapters explore the interactions of animal viruses with cell surface receptors; insulin receptors; determination of the size of neurotransmitter receptors by radiation inactivation-target size analysis; and protein glycosylation and receptor-ligand interactions. This book will be a valuable resource for students and practitioners in fields ranging from cell biology and biochemistry to physiology, endocrinology, and pharmacology.

Pulsatility in Neuroendocrine Systems

Pulsatility in Neuroendocrine Systems Book
Author : Jon E. Levine
Publisher : Academic Press
Release : 2013-10-22
ISBN : 148328834X
Language : En, Es, Fr & De

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Book Description :

Pulsatility is now recognized as a nearly ubiquitous functional feature of neuroendocrine systems. This volume presents a comprehensive guide to the established and emerging technologies being used to study the perplexing phenomenon of pulsatility. Molecular, cellular, physiological, and mathematical approaches are described in detail. In vitro methods for studying neuroendocrine pulsatility In vivo sampling and recording procedures for monitoring pulsatility in several species Improved quantitative and analytical methods for the study of hormone pulsatility

G Protein Coupled Receptors

G Protein Coupled Receptors Book
Author : Anonim
Publisher : Academic Press
Release : 2013-01-17
ISBN : 0123918723
Language : En, Es, Fr & De

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Book Description :

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers G protein coupled receptors Contains chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain

Essential Bioimaging Methods

Essential Bioimaging Methods Book
Author : P. Michael Conn
Publisher : Academic Press
Release : 2009-10-05
ISBN : 9780080963426
Language : En, Es, Fr & De

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Book Description :

Need a tested, reliable method that works? Put Essential Bioimaging Methods to work for you. Editor Michael Conn has hand-picked the most robust methods from his previously-published volumes in the Methods in Enzymology series. Many of these methods have been briefly updated by the authors that created them and use them in their research, and this book further refines and organizes existing content and focuses on methods that work, including MRI, fMRI, PET, Microscopic optical imaging and other. Part of the Reliable Lab Solution series, this volume provides clear advice and explicit protocols, providing updates to classic, tried-and-true methods and an essential addition to the bookshelf or workbench of any researcher in the field. * Highlights usefulness of techniques in basic research detailing MRI imaging of small animals, fMRI of Macaque monkeys, and baboon model of reperfused stroke * Built from volumes in the flagship brand, Methods in Enzymology * Provides tricks, tips and different approaches

G Protein Coupled Receptors

G Protein Coupled Receptors Book
Author : Anonim
Publisher : Academic Press
Release : 2013-01-28
ISBN : 012407944X
Language : En, Es, Fr & De

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Book Description :

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers G protein coupled receptors, and includes chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers G protein coupled receptors Contains chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation

Neuropeptide Analogs Conjugates and Fragments

Neuropeptide Analogs  Conjugates  and Fragments Book
Author : P. Michael Conn
Publisher : Academic Press
Release : 2013-10-22
ISBN : 1483217531
Language : En, Es, Fr & De

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Book Description :

Methods in Neurosciences, Volume 13: Neuropeptide Analogs, Conjugates, and Fragments covers the synthesis and characterization of peptide analogs, conjugates, and fragments, their use as ligands for receptors, and their role in the development and use of antisera. The book discusses techniques such as novel synthetic approaches; biotinylation; purification and characterization; radioligand techniques and assay development; use of agonists and antagonists; distinguishing receptor subtypes; conjugation to carrier proteins; antiidiotypic antibody development; and radiolabeling. Neuroscientists, biochemists, neurochemists, and pharmacologists will find the book useful.

Intermediary Nitrogen Metabolism

Intermediary Nitrogen Metabolism Book
Author : Anonim
Publisher : Academic Press
Release : 2012-12-02
ISBN : 0080926169
Language : En, Es, Fr & De

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Book Description :

This volume covers the most significant advances of the last ten years in understanding intermediary nitrogen metabolism in plants. The eight chapters comprise aspects of nitrate and nitrogen assimilation, symbiotic nitrogen fixation, glutamine and glutamate enzymology, amino acid biosynthesis, ureides, and polyamine and sulfur metabolism. The volume emphasizes molecular and genetic advances as well as biochemistry and physiology. Intermediary Nitrogen Metabolism will be of interest to all plant biochemists and molecular geneticists who study nitrogen metabolism, enzymology, and amino acids.