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Conjugate Addition Reactions In Organic Synthesis

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Conjugate Addition Reactions in Organic Synthesis

Conjugate Addition Reactions in Organic Synthesis Book
Author : P. Perlmutter
Publisher : Elsevier
Release : 2013-10-22
ISBN : 1483293785
Language : En, Es, Fr & De

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Book Description :

This book provides an introduction to the chemistry of conjugate reactions, a group of reactions that constitute one of the most important classes of chemical reactions in organic synthesis. The book is organised in terms of the major classes of conjugate acceptors. Within each of these classes, the chemistry and applications of conjugate additions with several different categories of nucleophiles have been examined. Where several different nucleophiles achieve the same synthetic transformation, they are cross-referenced within the book and qualitative comparisons offered where appropriate. Examples of the use of conjugate additions in total synthesis of important molecules are included, with a special emphasis throughout the book on stereoselectivity. This will be a useful main text for graduate and postgraduate courses on conjugate addition reactions or the Michael reaction. It could also serve as a supplementary text for courses on topics such as the chemistry of organocopper reagents, enamines and carbanion chemistry.

Conjugate Addition Reactions in Organic Synthesis

Conjugate Addition Reactions in Organic Synthesis Book
Author : Patrick Perlmutter
Publisher : Elsevier
Release : 2020-12-29
ISBN : 9780128186282
Language : En, Es, Fr & De

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Book Description :

Conjugate Addition Reactions in Organic Synthesis, second edition, provides an introduction to the chemistry of conjugate reactions, a group of reactions that constitute one of the most important classes of chemical reactions in organic synthesis. The book is organized according to class of acceptor rather than the class of nucleophile, which makes for easier synthetic problem solving. All aspects of conjugate addition reactions are covered, including theory, mechanism, catalysis, and total synthesis. Asymmetric processes are featured heavily, and there is emphasis on catalysis, given its importance in all aspects of organic synthesis today. Extensive examples in total synthesis illustrate how particular synthetic challenges are addressed and resolved with conjugate addition chemistry. The second edition features new coverage of acceptors and nucleophiles, as well as organocatalysis, gold catalysis, peptide catalysis, arene additions, and emerging areas such as biocatalytic methods and advances in mechanism theory. This book is an ideal reference for advanced undergraduates, post-graduates, researchers, and academics working in medicinal, pharmaceutical, polymer and industrial chemistry. Features a unique structure for this subject which enables readers to readily access information based on specific classes of conjugate acceptor Provides a thorough account of the latest thinking of the mechanistic basis of conjugate addition reactions and all the latest - and best - methods for achieving the highest selectivity in conjugate addition reactions Includes over 200 examples of total synthesis illustrating how particular synthetic challenges are addressed and resolved with conjugate addition chemistry Covers an up to date treatment of the latest aspects of conjugate addition reactions including inter alia, cascade reactions, organocatalysis and flow chemistry

Organocatalytic Enantioselective Conjugate Addition Reactions

Organocatalytic Enantioselective Conjugate Addition Reactions Book
Author : Jose L. Vicario
Publisher : Royal Society of Chemistry
Release : 2010
ISBN : 1849730245
Language : En, Es, Fr & De

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Book Description :

This book, unique in its field, is a comprehensive description of all the methodologies reported for carrying out conjugate addition reactions in a stereoselective way, using small chiral organic molecules as catalysts (organocatalysts). In the last 3-4 years, this has been a rapidly growing field in organic chemistry, and many papers have appeared reporting excellent protocols for carrying out these highly efficient transformations that compete well with other classical approachse using transition metal catalysts. A particularly attractive feature of this transformation relies upon the fact that the conjugate addition (Michael and Hetero-Michael reactions) is an extraoridinarily effective means to initiate cascade processes which result in the formation of complex molecules from very small and simple starting blocks. The book, written by noted experts, covers all recent advances in this not topic, and provides a good state-of-the-art review for organic chemists working in this field and all those who wish to start projects in this area. The Series is intended to provide an accessible reference for postgraduates and industrialists working in the field of catalysis and its applications. Books will be produced either as monographs or reference handbooks. The Series will cover research developments and applications of catalysis, in both academia and industry.

Organic Mechanisms

Organic Mechanisms Book
Author : Reinhard Bruckner
Publisher : Springer Science & Business Media
Release : 2010-01-20
ISBN : 3642036503
Language : En, Es, Fr & De

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Book Description :

This English edition of a best-selling and award-winning German textbook Reaction Mechanisms: Organic Reactions · Stereochemistry · Modern Synthetic Methods is aimed at those who desire to learn organic chemistry through an approach that is facile to understand and easily committed to memory. Michael Harmata, Norman Rabjohn Distinguished Professor of Organic Chemistry (University of Missouri) surveyed the accuracy of the translation, made certain contributions, and above all adapted its rationalizations to those prevalent in the organic chemistry community in the English-speaking world. Throughout the book fundamental and advanced reaction mechanisms are presented with meticulous precision. The systematic use of red "electron-pushing arrows" allows students to follow each transformation elementary step by elementary step. Mechanisms are not only presented in the traditional contexts of rate laws and substituent effects but, whenever possible, are illustrated using practical, useful and state-of-the-art reactions. The abundance of stereoselective reactions included in the treatise makes the reader familiar with key concepts of stereochemistry. The fundamental topics of the book address the needs of upper-level undergraduate students, while its advanced sections are intended for graduate-level audiences. Accordingly, this book is an essential learning tool for students and a unique addition to the reference desk of practicing organic chemists, who as life-long learners desire to keep abreast of both fundamental and applied aspects of our science. In addition, it will well serve ambitious students in chemistry-related fields such as biochemistry, medicinal chemistry and pharmaceutical chemistry. From the reviews: "Professor Bruckner has further refined his already masterful synthetic organic chemistry classic; the additions are seamless and the text retains the magnificent clarity, rigour and precision which were the hallmark of previous editions. The strength of the book stems from Professor Bruckner’s ability to provide lucid explanations based on a deep understanding of physical organic chemistry and to limit discussion to very carefully selected reaction classes illuminated by exquisitely pertinent examples, often from the recent literature. The panoply of organic synthesis is analysed and dissected according to fundamental structural, orbital, kinetic and thermodynamic principles with an effortless coherence that yields great insight and never over-simplifies. The perfect source text for advanced Undergraduate and Masters/PhD students who want to understand, in depth, the art of synthesis ." Alan C. Spivey, Imperial College London "Bruckner’s ‘Organic Mechanisms’ accurately reflects the way practicing organic chemists think and speak about organic reactions. The figures are beautifully drawn and show the way organic chemists graphically depict reactions. It uses a combination of basic valence bond pictures with more sophisticated molecular orbital treatments. It handles mechanisms both from the "electron pushing perspective" and from a kinetic and energetic view. The book will be very useful to new US graduate students and will help bring them to the level of sophistication needed to be serious researchers in organic chemistry." Charles P. Casey, University of Wisconsin-Madison "This is an excellent advanced organic chemistry textbook that provides a key resource for students and teachers alike." Mark Rizzacasa, University of Melbourne, Australia.

Asymmetric Conjugate Addition Reactions

Asymmetric Conjugate Addition Reactions Book
Author : Scott Bentley
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This thesis is concerned with the asymmetric conjugate addition reactions of a range of chiral nucloeophiles. Chapter 1 introduces the conjugate addition reaction as a valuable carbon-carbon and carbon-heteroatom bond forming reaction in organic chemistry, and explores the asymmet- ric conjugate addition of a range of chiral and achiral carbon and nitrogen nucleophiles to a range of acceptors. Chapter 2 explores the use of the N-benzyl-N-([alpha]-methylbenzyl)amino group as a chi- ral auxiliary, by employing the attempted conjugate additions of both N-benzyl-N-([alpha]- methylbenzyl)hydrazine and N -benzyl-N -([alpha]-methylbenzyl)hydroxylamine as chiral ammo- nia and water equivalents respectively. Chapter 3 describes the asymmetric and stereoselective preparation of a range of 4,4- disubstituted isoxazolidin-5-ones from the conjugate addition of lithium (S)-N-tert-butyl- dimethylsilyloxy-N -([alpha]-methylbenzyl)amide. The isoxazolidin-5-ones are then globally de- protected via hydrogenolysis, giving rise to the corresponding [beta]2,2,3-amino acids. Chapter 4 focuses on the development of a protocol to effect the conjugate addition of a chiral aniline equivalent. The scope of the reaction is delineated by varying both the nu- cleophile and the [alpha],[beta]-unsaturated ester. Finally, cyclisation of the [beta]-N-arylamino esters to the corresponding tetrahydroquinolines is explored, and an application to the synthesis of the natural product (-)-angustureine is presented. Chapter 5 contains full experimental procedures and characterisation data for all com- pounds synthesised in Chapters 2, 3 and 4.

The Chemistry of Organocopper Compounds

The Chemistry of Organocopper Compounds Book
Author : Zvi Rappoport,Ilan Marek
Publisher : John Wiley & Sons
Release : 2010-01-07
ISBN : 0470772964
Language : En, Es, Fr & De

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Book Description :

Copper in organic synthesis has seen a tremendous development over the past ten years. This text represents the most comprehensive survey on the use of Copper and Cuprates in organic synthesis. The first time that the Patai Series touches on Copper compounds, it contains contributions by leading experts, and delivers the quality expected from the Patai Series.

Advanced Organic Chemistry

Advanced Organic Chemistry Book
Author : Reinhard Bruckner
Publisher : Elsevier
Release : 2001-08-03
ISBN : 0080498809
Language : En, Es, Fr & De

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Book Description :

A best-selling mechanistic organic chemistry text in Germany, this text's translation into English fills a long-existing need for a modern, thorough and accessible treatment of reaction mechanisms for students of organic chemistry at the advanced undergraduate and graduate level. Knowledge of reaction mechanisms is essential to all applied areas of organic chemistry; this text fulfills that need by presenting the right material at the right level.

Comprehensive Organic Functional Group Transformations

Comprehensive Organic Functional Group Transformations Book
Author : Alan R. Katritzky,Stanley M. Roberts,Otto Meth-Cohn,Charles Wayne Rees
Publisher : Elsevier
Release : 1995
ISBN : 9780080423227
Language : En, Es, Fr & De

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Book Description :

This Volume covers the formation of carbon-carbon single-, double- and triple bonds by substitution and addition reactions as well as by various rearrangements. The formation of carbon-carbon multiple bonds by elimination and condensation procedures is fully documented. In addition the synthesis of carbon-hydrogen bonds principally by substitution and addition reactions is featured as is the preparation of a wide variety of carbon-centred anions, cations and radicals.

Comprehensive Organic Synthesis Additions to and substitutions at C C pi Bonds

Comprehensive Organic Synthesis  Additions to and substitutions at C C pi  Bonds Book
Author : Barry M. Trost,M.F. Semmelhack,Ian Fleming
Publisher : Elsevier
Release : 1991
ISBN : 9780080405957
Language : En, Es, Fr & De

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Book Description :

Volume 4 focuses on additions and the resulting substitutions at carbon-carbon &pgr;-bonds. Part 1 includes processes generally considered as simple polar reactions, reactive electrophiles and nucleophiles adding to alkenes and alkynes. A major topic is Michael-type addition to electron deficient &pgr;-bonds, featured in the first six chapters. In part 2 are collected the four general processes leading to nucleophilic aromatic substitution, including radical chain processes and transition metal activation through to &pgr;-complexation. Metal-activated addition (generally by nucleophiles) to alkenes and polyenes is presented in part 3, including allylic alkylation catalyzed by palladium. The coverage of nonpolar additions in part 4 includes radical additions, organometal addition (Heck reaction), carbene addition, and 1,3-dipolar cycloadditions.

Comprehensive Organic Synthesis

Comprehensive Organic Synthesis Book
Author : Anonim
Publisher : Newnes
Release : 2014-02-14
ISBN : 008097743X
Language : En, Es, Fr & De

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Book Description :

The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Second Edition an invaluable source, providing an authoritative overview of core concepts. Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers Contains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reduction Includes more than10,000 schemes and images Fully revised and updated; important growth areas—including combinatorial chemistry, new technological, industrial, and green chemistry developments—are covered extensively

Science of Synthesis Water in Organic Synthesis

Science of Synthesis  Water in Organic Synthesis Book
Author : Anonim
Publisher : Georg Thieme Verlag
Release : 2014-05-14
ISBN : 3131790415
Language : En, Es, Fr & De

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Book Description :

"Science of Synthesis: Water in Organic Synthesis" provides a comprehensive overview of a rapidly progressing field and a critical review of aqueous reactions by 47 experts. It covers almost all types of organic reactions, including special techniques with water and industrial applications, and has an emphasis on environmental aspects. This resource helps the organic chemist in gaining a thorough appreciation of the latest and most reliable available methods for using water in organic synthesis. It illustrates how water can often be a viable and green solvent in the laboratory and provides a detailed introduction to the subject: background information, evaluated methods, practical applications, industrial applications, special techniques, and an overview of the latest trends. // The content of this e-book was originally published in February 2012.

Stereoselective Multiple Bond Forming Transformations in Organic Synthesis

Stereoselective Multiple Bond Forming Transformations in Organic Synthesis Book
Author : Jean Rodriguez,Damien Bonne
Publisher : John Wiley & Sons
Release : 2015-05-04
ISBN : 1118672712
Language : En, Es, Fr & De

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Book Description :

Download Stereoselective Multiple Bond Forming Transformations in Organic Synthesis book written by Jean Rodriguez,Damien Bonne, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Strategic Applications of Named Reactions in Organic Synthesis

Strategic Applications of Named Reactions in Organic Synthesis Book
Author : Laszlo Kurti,Barbara Czako
Publisher : Elsevier
Release : 2005-04-29
ISBN : 0080575412
Language : En, Es, Fr & De

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Book Description :

Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. * The first reference work on named reactions to present colored schemes for easier understanding * 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples * An opening list of abbreviations includes both structures and chemical names * Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works * Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools * Extensive index quickly locates information using words found in text and drawings

Green Techniques for Organic Synthesis and Medicinal Chemistry

Green Techniques for Organic Synthesis and Medicinal Chemistry Book
Author : Wei Zhang,Berkeley W. Cue
Publisher : John Wiley & Sons
Release : 2018-01-16
ISBN : 1119288177
Language : En, Es, Fr & De

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Book Description :

An updated overview of the rapidly developing field of green techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.

Current Trends in Organic Synthesis

Current Trends in Organic Synthesis Book
Author : Carlo Scolastico,Francesco Nicotra
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461548012
Language : En, Es, Fr & De

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Book Description :

The last two decades have seen a rapid growth in the synthetic processing of both simple and complex molecules, aimed at meeting the needs of society in all aspects of life. Many efforts have been devoted to the development of new biologically active compounds, new materials with innovative properties such as bio-compatibility, new catalysts that allow highly selective transformations, and technologies that facilitate the synthetic pro cesses. This book is a compendium of recent progress in all these aspects of synthetic chemistry. It collects the lectures of the XII International Conference on Organic Synthesis, held in Venice from June 28 to July 2, 1998, in which the present state of art of this discipline has been reported. The topics covered include: combinatorial chemistry, new synthetic methods, stereo selective synthesis, metal-mediated synthesis, and target oriented synthesis. The book collects the contributions, in the mentioned topics, of 43 scientists from 19 different countries. The contributions presented in the Conference as plenary lectures are reported in the first section of the book. Particular attention has been dedicated to combinatorial chemistry, a new and promising methodology for the synthesis of libraries of pharmaco logically interesting compounds in order to allow the automatic pharmacological screening of thousands of compounds. The Conference has dedicated to combinatorial chemistry a mini-symposium in which scientists from academy and companies have described the current trends of this very new technology.

Organic Synthesis

Organic Synthesis Book
Author : Michael B Smith
Publisher : Academic Press
Release : 2016-11-22
ISBN : 0128008075
Language : En, Es, Fr & De

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Book Description :

Organic Synthesis, Fourth Edition, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature. In the Fourth Edition, the organization of the book has been improved to better serve students and professors and accommodate important updates in the field. The first chapter reviews basic retrosynthesis, conformations and stereochemistry. The next three chapters provide an introduction to and a review of functional group exchange reactions; these are followed by chapters reviewing protecting groups, oxidation and reduction reactions and reagents, hydroboration, selectivity in reactions. A separate chapter discusses strategies of organic synthesis, and he book then delves deeper in teaching the reactions required to actually complete a synthesis. Carbon-carbon bond formation reactions using both nucleophilic carbon reactions are presented, and then electrophilic carbon reactions, followed by pericyclic reactions and radical and carbene reactions. The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry. Throughout the text, Organic Synthesis, Fourth Edition utilizes Spartan-generated molecular models, class tested content, and useful pedagogical features to aid student study and retention, including Chapter Review Questions, and Homework Problems. PowerPoint© presentations and answer keys are also available online to support instructors. Fully revised and updated throughout, and teorganized into 19 chapters for a more cogent and versatile presentation of concepts Includes reaction examples taken from literature research reported between 2010-2015 Features new full-color art and new chapter content on process chemistry and green organic chemistry Offers valuable study and teaching tools, including Chapter Review Questions and Homework Problems for students; Lecture presentations and other useful material for qualified course instructors

Chiral Lewis Acids in Organic Synthesis

Chiral Lewis Acids in Organic Synthesis Book
Author : Jacek Mlynarski
Publisher : John Wiley & Sons
Release : 2017-10-23
ISBN : 3527341293
Language : En, Es, Fr & De

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Book Description :

A complete overview covering the application of metal-based chiral Lewis acids from all parts of the periodic table, the Author emphasizes the most recent contributions to the field as well as prominent direction of development. The book discusses the design of chiral complexes as well as a wide spectrum of reactions promoted by various chiral Lewis acids, including water-compatible acids as well as the most important applications in the chemical and pharmaceutical industries. A must-have for catalytic and organic chemists working in the field, both in academia and industry, as well as pharmaceutical and medicinal chemists.

Catalytic Asymmetric Conjugate Reactions

Catalytic Asymmetric Conjugate Reactions Book
Author : Armando Cordova
Publisher : John Wiley & Sons
Release : 2010-12-01
ISBN : 9783527632091
Language : En, Es, Fr & De

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Book Description :

This unique and long-awaited handbook on this important topic in the hot field of stereoselective organic synthesis covers several types of nucleophiles. Top international authors deal with modern forms of achieving stereoselective conjugate additions based on the use of chiral auxiliaries or asymmetric catalysis, such as P-N ligands, organocatalysis, domino reactions, Lewis acid and base catalysis. There is also a discussion of the employment of enantioselective conjugate addition transformations in total synthesis of important molecules. With its reliable and previously unpublished experimental procedures, this is a true source of high quality information.