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Conjugate Addition Reactions In Organic Synthesis

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Conjugate Addition Reactions in Organic Synthesis

Conjugate Addition Reactions in Organic Synthesis Book
Author : P. Perlmutter
Publisher : Elsevier
Release : 2013-10-22
ISBN : 1483293785
Language : En, Es, Fr & De

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Book Description :

This book provides an introduction to the chemistry of conjugate reactions, a group of reactions that constitute one of the most important classes of chemical reactions in organic synthesis. The book is organised in terms of the major classes of conjugate acceptors. Within each of these classes, the chemistry and applications of conjugate additions with several different categories of nucleophiles have been examined. Where several different nucleophiles achieve the same synthetic transformation, they are cross-referenced within the book and qualitative comparisons offered where appropriate. Examples of the use of conjugate additions in total synthesis of important molecules are included, with a special emphasis throughout the book on stereoselectivity. This will be a useful main text for graduate and postgraduate courses on conjugate addition reactions or the Michael reaction. It could also serve as a supplementary text for courses on topics such as the chemistry of organocopper reagents, enamines and carbanion chemistry.

Conjugate Addition Reactions in Organic Synthesis

Conjugate Addition Reactions in Organic Synthesis Book
Author : Patrick Perlmutter
Publisher : Elsevier
Release : 2020-12-29
ISBN : 9780128186282
Language : En, Es, Fr & De

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Book Description :

Conjugate Addition Reactions in Organic Synthesis, second edition, provides an introduction to the chemistry of conjugate reactions, a group of reactions that constitute one of the most important classes of chemical reactions in organic synthesis. The book is organized according to class of acceptor rather than the class of nucleophile, which makes for easier synthetic problem solving. All aspects of conjugate addition reactions are covered, including theory, mechanism, catalysis, and total synthesis. Asymmetric processes are featured heavily, and there is emphasis on catalysis, given its importance in all aspects of organic synthesis today. Extensive examples in total synthesis illustrate how particular synthetic challenges are addressed and resolved with conjugate addition chemistry. The second edition features new coverage of acceptors and nucleophiles, as well as organocatalysis, gold catalysis, peptide catalysis, arene additions, and emerging areas such as biocatalytic methods and advances in mechanism theory. This book is an ideal reference for advanced undergraduates, post-graduates, researchers, and academics working in medicinal, pharmaceutical, polymer and industrial chemistry. Features a unique structure for this subject which enables readers to readily access information based on specific classes of conjugate acceptor Provides a thorough account of the latest thinking of the mechanistic basis of conjugate addition reactions and all the latest - and best - methods for achieving the highest selectivity in conjugate addition reactions Includes over 200 examples of total synthesis illustrating how particular synthetic challenges are addressed and resolved with conjugate addition chemistry Covers an up to date treatment of the latest aspects of conjugate addition reactions including inter alia, cascade reactions, organocatalysis and flow chemistry

Modern Methods of Organic Synthesis

Modern Methods of Organic Synthesis Book
Author : W. Carruthers,Iain Coldham
Publisher : Cambridge University Press
Release : 2004-10-14
ISBN : 9780521778305
Language : En, Es, Fr & De

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Book Description :

Textbook on modern methods of organic synthesis.

Organocatalytic Enantioselective Conjugate Addition Reactions

Organocatalytic Enantioselective Conjugate Addition Reactions Book
Author : Jose L. Vicario
Publisher : Royal Society of Chemistry
Release : 2010
ISBN : 1849730245
Language : En, Es, Fr & De

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Book Description :

This book, unique in its field, is a comprehensive description of all the methodologies reported for carrying out conjugate addition reactions in a stereoselective way, using small chiral organic molecules as catalysts (organocatalysts). In the last 3-4 years, this has been a rapidly growing field in organic chemistry, and many papers have appeared reporting excellent protocols for carrying out these highly efficient transformations that compete well with other classical approachse using transition metal catalysts. A particularly attractive feature of this transformation relies upon the fact that the conjugate addition (Michael and Hetero-Michael reactions) is an extraoridinarily effective means to initiate cascade processes which result in the formation of complex molecules from very small and simple starting blocks. The book, written by noted experts, covers all recent advances in this not topic, and provides a good state-of-the-art review for organic chemists working in this field and all those who wish to start projects in this area. The Series is intended to provide an accessible reference for postgraduates and industrialists working in the field of catalysis and its applications. Books will be produced either as monographs or reference handbooks. The Series will cover research developments and applications of catalysis, in both academia and industry.

Comprehensive Organic Synthesis Additions to and substitutions at C C pi Bonds

Comprehensive Organic Synthesis  Additions to and substitutions at C C pi  Bonds Book
Author : Barry M. Trost,M.F. Semmelhack,Ian Fleming
Publisher : Elsevier
Release : 1991
ISBN : 9780080405957
Language : En, Es, Fr & De

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Book Description :

Volume 4 focuses on additions and the resulting substitutions at carbon-carbon &pgr;-bonds. Part 1 includes processes generally considered as simple polar reactions, reactive electrophiles and nucleophiles adding to alkenes and alkynes. A major topic is Michael-type addition to electron deficient &pgr;-bonds, featured in the first six chapters. In part 2 are collected the four general processes leading to nucleophilic aromatic substitution, including radical chain processes and transition metal activation through to &pgr;-complexation. Metal-activated addition (generally by nucleophiles) to alkenes and polyenes is presented in part 3, including allylic alkylation catalyzed by palladium. The coverage of nonpolar additions in part 4 includes radical additions, organometal addition (Heck reaction), carbene addition, and 1,3-dipolar cycloadditions.

Cycloaddition Reactions in Organic Synthesis

Cycloaddition Reactions in Organic Synthesis Book
Author : W. Carruthers
Publisher : Elsevier
Release : 2013-10-22
ISBN : 008091232X
Language : En, Es, Fr & De

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Book Description :

Demonstrates the wide scope of cycloaddition reactions, including the Diels-Alder reaction, the ene reaction, 1,3-dipolar cycloadditions and [2+2] cycloadditions in organic synthesis. The author, a leading exponent of the subject, illustrates the ways in which they can be employed in the synthesis of a wide range of carbocyclic and heterocyclic compounds, including a variety of natural products of various types. Special attention is given to intramolecular reactions, which often provide a rapid and efficient route to polycyclic compounds, and to the stereochemistry of the reactions, including recent and developing work on enantioselective synthesis.

Methods of Non Amino Acid Synthesis Second Edition

Methods of Non    Amino Acid Synthesis  Second Edition Book
Author : Michael Bryant Smith
Publisher : CRC Press
Release : 2013-10-23
ISBN : 1466577924
Language : En, Es, Fr & De

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Book Description :

Although less common than α-amino acids, non-α-amino acids—where the amino group is not on the carbon immediately adjacent to the carboxyl group but is attached to another carbon in the chain (for example, the β, γ, δ carbon)—are components of biologically important molecules, are significant in the pharmaceutical industry, and are useful starting materials for many areas of organic chemistry. Since the publication of the first edition of this book nearly 20 years ago, synthetic work devoted to the preparation of non- α-amino acids has expanded greatly. Methods of Non-α-Amino Acid Synthesis, Second Edition has been extensively rewritten and reorganized, providing an up-to-date review of strategies and methods for non-α-amino acid synthesis, particularly those amino acids that are key synthetic intermediates or important compounds in their own right. It focuses on acyclic amino acids of C3–C10, but also aminoalkanoic carboxylic acids, aminoalkenoic acids, and aminoalkynoic acids. The new edition contains many updated references and has a greater emphasis on the biological importance of non-α-amino acids. In addition to an array of synthetic methods, the book offers discussions on why non-α-amino acids are important. The book covers synthetic methods that rely on substituent refunctionalization, the conversion of cyclic precursors to acyclic amino acids, conjugate addition reactions, and enolate anion reactions and condensation reactions that lead to non-α-amino acids. It also examines reactions and strategies that lead to good diastereoselectivity and enantioselectivity during synthesis. A chapter devoted to biologically important amino acids includes separate sections on GABA, GABOB, carnitine, DAVA, statine, and other significant amino acids as well as a new section on peptides and proteins that contain non-α-amino acids. The final chapter addresses aminocyclic and heterocyclic amino acids.

Organozinc Reagents in Organic Synthesis

Organozinc Reagents in Organic Synthesis Book
Author : Ender Erdik
Publisher : CRC Press
Release : 1996-06-05
ISBN : 9780849391514
Language : En, Es, Fr & De

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Book Description :

Organozinc reagents are used extensively in organic synthesis to find useful pathways to organic products. Illustrated and tabulated with over 950 equations, schemes, tables, and figures, Organozinc Reagents in Organic Synthesis provides an overall picture of the chemistry of organozinc compounds. Written by a professor of organic chemistry, the book familiarizes the reader with the reactions involving organozinc reagents that have general usefulness in synthesis. Emphasis is placed on preparation methods and reactivity of organozinc reagents. Reactions are summarized in equations and schemes, making it easy for you to see the characteristics of each type of reaction.

Some Modern Methods of Organic Synthesis

Some Modern Methods of Organic Synthesis Book
Author : W. Carruthers
Publisher : CUP Archive
Release : 1971-10-31
ISBN : 9780521096430
Language : En, Es, Fr & De

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Book Description :

Download Some Modern Methods of Organic Synthesis book written by W. Carruthers, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Catalytic Asymmetric Conjugate Reactions

Catalytic Asymmetric Conjugate Reactions Book
Author : Armando Cordova
Publisher : John Wiley & Sons
Release : 2010-12-01
ISBN : 9783527632091
Language : En, Es, Fr & De

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Book Description :

This unique and long-awaited handbook on this important topic in the hot field of stereoselective organic synthesis covers several types of nucleophiles. Top international authors deal with modern forms of achieving stereoselective conjugate additions based on the use of chiral auxiliaries or asymmetric catalysis, such as P-N ligands, organocatalysis, domino reactions, Lewis acid and base catalysis. There is also a discussion of the employment of enantioselective conjugate addition transformations in total synthesis of important molecules. With its reliable and previously unpublished experimental procedures, this is a true source of high quality information.

The Nitro Group in Organic Synthesis

The Nitro Group in Organic Synthesis Book
Author : Noboru Ono
Publisher : John Wiley & Sons
Release : 2003-05-08
ISBN : 9780471458463
Language : En, Es, Fr & De

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Book Description :

The most useful reactions of organonitro compounds in organic synthesis Compounds containing nitro groups are useful intermediates for the synthesis of natural products and other complex organic molecules. The Nitro Group in Organic Synthesis focuses on reactions that proceed under mild conditions, important functional groups that can be synthesized by conversion of nitro groups, and the stereoselectivity of reactions of nitro compounds. These issues are of great importance to practicing researchers in today's pharmaceutical, agrochemical, and fine chemical industries. The Nitro Group in Organic Synthesis also emphasizes environmentally-friendly methods for nitration, the importance of aliphatic nitro compounds, and modern preparation of nitro compounds. Other topics discussed include: * Henry reaction * Asymmetric Michael addition * Alkylation, acylation, halogenation, and related reactions of RNO2 * Substitution and elimination of NO2 and RNO2 The Nitro Group in Organic Synthesis is a useful resource for researchers and students in organic and medicinal chemistry.

Enantioselective Organocatalyzed Reactions II

Enantioselective Organocatalyzed Reactions II Book
Author : Rainer Mahrwald
Publisher : Springer Science & Business Media
Release : 2011-08-03
ISBN : 9789048138678
Language : En, Es, Fr & De

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Book Description :

Organocatalyzed Reactions I and II presents a timely summary of organocatalysed reactions including: a) Enantioselective C-C bond formation processes e.g. Michael-addition, Mannich-reaction, Hydrocyanation (Strecker-reaction), aldol reaction, allylation, cycloadditions, aza-Diels-Alder reactions, benzoin condensation, Stetter reaction, conjugative Umpolung, asymmetric Friedel-Crafts reactions; b) Asymmetric enantioselective reduction processes e.g. Reductive amination of aldehydes or ketones, asymmetric transfer hydrogenation; c) Asymmetric enantioselective oxidation processes; d) Asymmetric epoxidation, Bayer-Villiger oxidation; e) Enantioselective a-functionalization; f) A-alkylation of ketones, a-halogenation and a-oxidation of carbonyl compounds.

Organolithiums in Enantioselective Synthesis

Organolithiums in Enantioselective Synthesis Book
Author : David M. Hodgson,Peter Andrew Beak
Publisher : Springer Science & Business Media
Release : 2003-04-30
ISBN : 3540001042
Language : En, Es, Fr & De

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Book Description :

with contributions by numerous experts

Science of Synthesis Houben Weyl Methods of Molecular Transformations Vol 33

Science of Synthesis  Houben Weyl Methods of Molecular Transformations Vol  33 Book
Author : Anonim
Publisher : Georg Thieme Verlag
Release : 2014-05-14
ISBN : 3131720913
Language : En, Es, Fr & De

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Book Description :

Science of Synthesis provides a critical review of the synthetic methodology developed from the early 1800s to date for the entire field of organic and organometallic chemistry. As the only resource providing full-text descriptions of organic transformations and synthetic methods as well as experimental procedures, Science of Synthesis is therefore a unique chemical information tool. Over 1000 world-renowned experts have chosen the most important molecular transformations for a class of organic compounds and elaborated on their scope and limitations. The systematic, logical and consistent organization of the synthetic methods for each functional group enables users to quickly find out which methods are useful for a particular synthesis and which are not. Effective and practical experimental procedures can be implemented quickly and easily in the lab.// The content of this e-book was originally published in December 2006.

Organic Synthesis

Organic Synthesis Book
Author : Paul Wyatt,Stuart Warren
Publisher : John Wiley & Sons
Release : 2013-05-20
ISBN : 1118681444
Language : En, Es, Fr & De

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Book Description :

Organic Synthesis: Strategy and Control is the long-awaited sequel to Stuart Warren’s bestseller Organic Synthesis: The Disconnection Approach, which looked at the planning behind the synthesis of compounds. This unique book now provides a comprehensive, practical account of the key concepts involved in synthesising compounds and focuses on putting the planning into practice. The two themes of the book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work. The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. A comprehensive, practical account of the key concepts involved in synthesising compounds Takes a mechanistic approach, which explains reactions and gives guidelines on how reactions might behave in different situations Focuses on reactions that really work rather than those with limited application Contains extensive, up-to-date references in each chapter Students and professional chemists familiar with Organic Synthesis: The Disconnection Approach will enjoy the leap into a book designed for chemists at the coalface of organic synthesis.

Modern Rhodium Catalyzed Organic Reactions

Modern Rhodium Catalyzed Organic Reactions Book
Author : P. Andrew Evans
Publisher : John Wiley & Sons
Release : 2006-03-06
ISBN : 352760409X
Language : En, Es, Fr & De

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Book Description :

Rhodium has proven to be an extremely useful metal due to its ability to catalyze an array of synthetic transformations, with quite often-unique selectivity. Hydrogenation, C-H activation, allylic substitution, and numerous other reactions are catalyzed by this metal, which presumably accounts for the dramatic increase in the number of articles that have recently emerged on the topic. P. Andrew Evans, the editor of this much-needed book, has assembled an internationally renowned team to present the first comprehensive coverage of this important area. The book features contributions from leaders in the field of rhodium-catalyzed reactions, and thereby provides a detailed account of the most current developments, including: Rhodium-Catalyzed Asymmetric Hydrogenation (Zhang) Rhodium-Catalyzed Hydroborations and Related Reactions (Brown) Rhodium-Catalyzed Asymmetric Addition of Organometallic Reagents to Electron Deficient Olefins (Hayashi) Recent Advances in Rhodium(I)-Catalyzed Asymmetric Olefin Isomerization and Hydroacylation Reactions (Fu) Stereoselective Rhodium(I)-Catalyzed Hydroformylation and Silylformylation Reactions and Their Application to Organic Synthesis (Leighton) Carbon-Carbon Bond-Forming Reactions Starting from Rh-H or Rh-Si Species (Matsuda) Rhodium(I)-Catalyzed Cycloisomerization and Cyclotrimerization Reactions (Ojima) The Rhodium(I)-Catalyzed Alder-ene Reaction (Brummond) Rhodium-Catalyzed Nucleophilic Ring Cleaving Reactions of Allylic Ethers and Amines (Fagnou) Rhodium(I)-Catalyzed Allylic Substitution Reactions and their Applications to Target Directed Synthesis (Evans) Rhodium(I)-Catalyzed [2+2+1] and [4+1] Carbocyclization Reactions (Jeong) Rhodium(I)-Catalyzed [4+2] and [4+2+2] Carbocyclizations (Robinson) Rhodium(I)-Catalyzed [5+2], [6+2], and [5+2+1] Cycloadditions: New Reactions for Organic Synthesis (Wender) Rhodium(II)-Stabilized Carbenoids Containing both Donor and Acceptor Substituents (Davies) Chiral Dirhodium(II)Carboxamidates for Asymmetric Cyclopropanation and Carbon-Hydrogen Insertion Reactions (Doyle) Cyclopentane Construction by Rhodium(II)-Mediated Intramolecular C-H Insertion (Taber) Rhodium(II)-Catalyzed Oxidative Amination (DuBois) Rearrangement Processes of Oxonium and Ammonium Ylides Formed by Rhodium(II)-Catalyzed Carbene-Transfer (West) Rhodium(II)-Catalyzed 1,3-Dipolar Cycloaddition Reactions (Austin) "Modern Rhodium-Catalyzed Organic Reactions" is an essential reference text for researchers at all levels in the general area of organic chemistry. This book provides an invaluable overview of the most significant developments in this important area of research, and will no doubt be an essential text for researchers at academic institutions and professionals at pharmaceutical/agrochemical companies.

The Chemistry of Organocopper Compounds

The Chemistry of Organocopper Compounds Book
Author : Zvi Rappoport,Ilan Marek
Publisher : John Wiley & Sons
Release : 2010-01-07
ISBN : 0470772964
Language : En, Es, Fr & De

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Book Description :

Copper in organic synthesis has seen a tremendous development over the past ten years. This text represents the most comprehensive survey on the use of Copper and Cuprates in organic synthesis. The first time that the Patai Series touches on Copper compounds, it contains contributions by leading experts, and delivers the quality expected from the Patai Series.

Asymmetric Synthesis II

Asymmetric Synthesis II Book
Author : Mathias Christmann,Stefan Bräse
Publisher : John Wiley & Sons
Release : 2013-04-12
ISBN : 3527652264
Language : En, Es, Fr & De

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Book Description :

Download Asymmetric Synthesis II book written by Mathias Christmann,Stefan Bräse, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cyclization Reactions

Cyclization Reactions Book
Author : C. Thebtaranonth,Yodhathai Thebtaranonth
Publisher : CRC Press
Release : 1993-05-01
ISBN : 9780849378614
Language : En, Es, Fr & De

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Book Description :

Cyclization Reactions provides a quick update of the latest advances in cyclization reactions. It covers the basic principles of cyclization chemistry, emphasizing practical applications. Chapters are organized according to the different cyclization intermediates-cationic, radical, anionic, and metal complex intermediates. The last chapter covers macrolactonization, vicinal tricarbonal, and Bergman (enediyne) reactions, which are of particular interest today. More than 2,600 structures illustrate key concepts throughout the book. Various cyclizations are organized into mechanistic groups to help researchers choose and change between methods when searching for maximum efficiency in synthesis. Critical coverage of the literature up to 1992 is provided. Cyclization Reactions is essential reading for anyone involved in the synthesis of ring compounds or who is seeking a rapid overview of the field. Newcomers as well as experienced researchers will benefit from this book. It also is excellent reference material for students at the advanced undergraduate and graduate levels.

Organic Reaction Mechanisms 2009

Organic Reaction Mechanisms 2009 Book
Author : A. C. Knipe
Publisher : John Wiley & Sons
Release : 2011-10-28
ISBN : 1119961041
Language : En, Es, Fr & De

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Book Description :

Organic Reaction Mechanisms 2009, the 45th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2009. The following classes of organic reaction mechanisms are comprehensively reviewed: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Polar Addition Reactions Cycloaddition Reactions Molecular Rearrangements An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation. This volume includes a 5-year cumulative index.