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Computer Aided Vaccine Design

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Computer Aided Vaccine Design

Computer Aided Vaccine Design Book
Author : Joo Chuan Tong,Shoba Ranganathan
Publisher : Elsevier
Release : 2013-07-31
ISBN : 1908818417
Language : En, Es, Fr & De

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Book Description :

Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates. Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics. Essential reading for any biologist who wants to understand methods of computer-aided vaccine design Description of available data sources and publicly available software, with detailed analysis of strengths and weaknesses Theoretical concepts and practical examples of database design and development for a virtual screening campaign

Scientific Modeling and Simulations

Scientific Modeling and Simulations Book
Author : Sidney Yip,Tomas Diaz Rubia
Publisher : Springer Science & Business Media
Release : 2010-04-07
ISBN : 1402097417
Language : En, Es, Fr & De

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Book Description :

Although computational modeling and simulation of material deformation was initiated with the study of structurally simple materials and inert environments, there is an increasing demand for predictive simulation of more realistic material structure and physical conditions. In particular, it is recognized that applied mechanical force can plausibly alter chemical reactions inside materials or at material interfaces, though the fundamental reasons for this chemomechanical coupling are studied in a material-speci c manner. Atomistic-level s- ulations can provide insight into the unit processes that facilitate kinetic reactions within complex materials, but the typical nanosecond timescales of such simulations are in contrast to the second-scale to hour-scale timescales of experimentally accessible or technologically relevant timescales. Further, in complex materials these key unit processes are “rare events” due to the high energy barriers associated with those processes. Examples of such rare events include unbinding between two proteins that tether biological cells to extracellular materials [1], unfolding of complex polymers, stiffness and bond breaking in amorphous glass bers and gels [2], and diffusive hops of point defects within crystalline alloys [3].

Computer Aided Drug Design

Computer Aided Drug Design Book
Author : Dev Bukhsh Singh
Publisher : Springer Nature
Release : 2020-10-09
ISBN : 9811568154
Language : En, Es, Fr & De

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Book Description :

This book provides up-to-date information on bioinformatics tools for the discovery and development of new drug molecules. It discusses a range of computational applications, including three-dimensional modeling of protein structures, protein-ligand docking, and molecular dynamics simulation of protein-ligand complexes for identifying desirable drug candidates. It also explores computational approaches for identifying potential drug targets and for pharmacophore modeling. Moreover, it presents structure- and ligand-based drug design tools to optimize known drugs and guide the design of new molecules. The book also describes methods for identifying small-molecule binding pockets in proteins, and summarizes the databases used to explore the essential properties of drugs, drug-like small molecules and their targets. In addition, the book highlights various tools to predict the absorption, distribution, metabolism, excretion (ADME) and toxicity (T) of potential drug candidates. Lastly, it reviews in silico tools that can facilitate vaccine design and discusses their limitations.

Molecular Docking for Computer Aided Drug Design

Molecular Docking for Computer Aided Drug Design Book
Author : Mohane S. Coumar
Publisher : Academic Press
Release : 2021-03-01
ISBN : 0128223138
Language : En, Es, Fr & De

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Book Description :

Molecular Docking for Computer-Aided Drug Design: Fundamentals, Techniques, Resources and Applications offers in-depth coverage on the use of molecular docking for drug design. The book is divided into three main sections that cover basic techniques, tools, web servers and applications. It is an essential reference for students and researchers involved in drug design and discovery. Covers the latest information and state-of-the-art trends in structure-based drug design methodologies Includes case studies that complement learning Consolidates fundamental concepts and current practice of molecular docking into one convenient resource

Computational Immunology

Computational Immunology Book
Author : Shyamasree Ghosh
Publisher : CRC Press
Release : 2020-01-31
ISBN : 1351023497
Language : En, Es, Fr & De

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Book Description :

Computational Immunology: Applications focuses on different mathematical models, statistical tools, techniques, and computational modelling that helps in understanding complex phenomena of the immune system and its biological functions. The book also focuses on the latest developments in computational biology in designing of drugs, targets, biomarkers for early detection and prognosis of a disease. It highlights the applications of computational methods in deciphering the complex processes of the immune system and its role in health and disease. This book discusses the most essential topics, including Next generation sequencing (NGS) and computational immunology Computational modelling and biology of diseases Drug designing Computation and identification of biomarkers Application in organ transplantation Application in disease detection and therapy Computational methods and applications in understanding of the invertebrate immune system S Ghosh is MSc, PhD, PGDHE, PGDBI, is PhD from IICB, CSIR, Kolkata, awarded the prestigious National Scholarship from the Government of India. She has worked and published extensively in glycobiology, sialic acids, immunology, stem cells and nanotechnology. She has authored several publications that include books and encyclopedia chapters in reputed journals and books.

Computer Aided Applications in Pharmaceutical Technology

Computer Aided Applications in Pharmaceutical Technology Book
Author : Jelena Djuris
Publisher : Elsevier
Release : 2013-04-10
ISBN : 1908818328
Language : En, Es, Fr & De

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Book Description :

Research and development in the pharmaceutical industry is a time-consuming and expensive process, making it difficult for newly developed drugs to be formulated into commercially available products. Both formulation and process development can be optimized by means of statistically organized experiments, artificial intelligence and other computational methods. Simultaneous development and investigation of pharmaceutical products and processes enables application of quality by design concept that is being promoted by the regulatory authorities worldwide. Computer-aided applications in pharmaceutical technology covers the fundamentals of experimental design application and interpretation in pharmaceutical technology, chemometric methods with emphasis of their application in process control, neural computing (artificial neural networks, fuzzy logic and decision trees, evolutionary computing and genetic algorithms, self-organizing maps), computer-aided biopharmaceutical characterization as well as application of computational fluid dynamics in pharmaceutical technology. All of these techniques are essential tools for successful building of quality into pharmaceutical products and processes from the early stage of their development to selection of the optimal ones. In addition to theoretical aspects of various methods, the book provides numerous examples of their application in the field of pharmaceutical technology. A comprehensive review of the current state of the art on various computer aided applications in pharmaceutical technology Case studies are presented in order to facilitate understanding of various concepts in computer-aided applications

Annual Report

Annual Report Book
Author : India. Department of Scientific & Industrial Research
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Annual Report book written by India. Department of Scientific & Industrial Research, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Immunoinformatics

Immunoinformatics Book
Author : Gregory R. Bock,Jamie A. Goode
Publisher : John Wiley & Sons
Release : 2004-03-05
ISBN : 0470090758
Language : En, Es, Fr & De

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Book Description :

The astounding diversity of the immune system and the complexity of its regulatory pathways makes immunology a combinatorial science. Computational analysis has therefore become an essential element of immunology research and this has led to the creation of the emerging field of immunoinformatics. This book is the first to feature thorough coverage of this new field. Immunoinformatics facilitates the understanding of immune function by modelling the interactions among immunological components. Biological research provides ever deeper insights into the complexity of living organisms while computer science provides an effective means to store and analyse large volumes of complex data. Combining the two fields increases the efficiency of biological research and offers the potential for major advances in the study of biological systems. This book encompasses key developments in immunoinformatics, including immunological databases, sequence analysis, structure modelling, mathematical modelling of the immune system, simulation of laboratory experiments, statistical support for immunological experimentation and immunogenomics. The difficulties in effective application of bioinformatic tools in immunology arise at both ends of the spectrum: most immunologists have only a limited comprehension of sophisticated data analysis and applicability and limitations, while the average computer scientist lacks knowledge of the depth and complexity of biological data. The purpose of this book, therefore, is to present contributions from a multidisciplinary team of biologists and computer scientists to explore the issues related to better understanding of immune function and, in particular, to help apply new computer science methods to immunological research. Related Novartis Foundation symposia: 247 In Silico Simulation of Biological Processes Chair: Denis Noble 252 Generation and effector functions of regulatory lymphocytes Chair: Jean-François Bach

Computer aided Molecular Design

Computer aided Molecular Design Book
Author : William Graham Richards
Publisher : Vch Pub
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Computer aided Molecular Design book written by William Graham Richards, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Annual Report Council of Scientific and Industrial Research

Annual Report   Council of Scientific and Industrial Research Book
Author : Council of Scientific & Industrial Research (India)
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Annual Report Council of Scientific and Industrial Research book written by Council of Scientific & Industrial Research (India), available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Science Culture

Science   Culture Book
Author : Anonim
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Proceedings

Proceedings Book
Author : Anonim
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Post Genomic Approaches in Drug and Vaccine Development

Post Genomic Approaches in Drug and Vaccine Development Book
Author : Kishore R. Sakharkar,Meena K. Sakharkar ,Ramesh Chandra
Publisher : River Publishers
Release : 2015-04-11
ISBN : 8793102844
Language : En, Es, Fr & De

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Book Description :

Over the past decade, genome sequencing projects and the associated efforts have facilitated the discovery of several novel disease targets and the approval of several innovative drugs. To further exploit this data for human health and disease, there is a need to understand the genome data itself in detail, discover novel targets, understand their role in physiological pathways and associated diseases, with the aim to translate these discoveries to clinical and preventive medicine. It is equally important to understand the labors and limitations in integrating clinical phenotypes with genomic, transcriptomic, proteomic and metabolomic approaches. This book focuses on some key advances in the field. Technical topics discussed in the book include: Drug discoveryTarget identification and prioritizationHypothesis driven multi-target drug designGenomics in vaccine developmentGene regulatory networks Vaccine design and developmentPrediction of drug side effects in silico

India a Reference Annual

India  a Reference Annual Book
Author : India. Ministry of Information and Broadcasting
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download India a Reference Annual book written by India. Ministry of Information and Broadcasting, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Computer Aided Design and Optimization of Probes for Hepatic Microwave Ablation

Computer Aided Design and Optimization of Probes for Hepatic Microwave Ablation Book
Author : Punit Prakash
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Computer Aided Design and Optimization of Probes for Hepatic Microwave Ablation book written by Punit Prakash, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Genetic Engineering and Biotechnology Monitor

Genetic Engineering and Biotechnology Monitor Book
Author : Anonim
Publisher : Unknown
Release : 1988
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Computer Aided Drug Design the Hcv Family Example

Computer Aided Drug Design  the Hcv Family Example  Book
Author : Dimitrios Vlachakis
Publisher : Lulu.com
Release : 2011-06-01
ISBN : 0557772435
Language : En, Es, Fr & De

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Book Description :

Hepatitis C and Dengue viruses belong to the family of Flaviviridae. Viruses in this family are enveloped, have positive-sense RNA and are responsible for a variety of life threatening diseases. Hepatitis C virus is the major etiological agent of post-transfusion hepatitis worldwide. An estimated 3 % of the world's population is infected with HCV according to the World Health Organization. Infection with HCV will most regularly result in chronic hepatitis, which leads to liver cirrhosis, hepatocellular carcinoma and liver failure. Dengue is currently the most important viral disease transmitted by mosquitoes afflicting humans the world context. Clinical symptoms range from mild fevers to a severe haemorrhagic disease. To date neither specific antiviral treatments exist nor are there any vaccines available for both infections. Thus there is an urgent need for new therapies.

The Trade Marks Journal

The Trade Marks Journal Book
Author : Anonim
Publisher : Unknown
Release : 2000-01-05
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Computer Aided Software Design

Computer Aided Software Design Book
Author : Max Schindler
Publisher : John Wiley & Sons Incorporated
Release : 1990
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Now with the advent of CASE tools, you can start to build your very own software--for your specific needs. This book presents a detailed guide to the use of these tools that puts the problems, solutions, and tradeoffs of personal software development into perspective--in plain English. Included is expert guidance on software methodologies, computer languages, and the management of software. You will also learn about architectural design, algorithms, descriptive languages, programming, and futuristic subjects such as artificial intelligence. Useful appendices cover computer history, software jargon, and supplier information.

Computer aided Molecular Design

Computer aided Molecular Design Book
Author : Anonim
Publisher : Unknown
Release : 1985
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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