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Computational Non coding RNA Biology

Computational Non coding RNA Biology Book
Author : Yun Zheng
Publisher : Academic Press
Release : 2018-09-14
ISBN : 0128143665
Language : En, Es, Fr & De

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Book Description :

Computational Non-coding RNA Biology is a resource for the computation of non-coding RNAs. The book covers computational methods for the identification and quantification of non-coding RNAs, including miRNAs, tasiRNAs, phasiRNAs, lariat originated circRNAs and back-spliced circRNAs, the identification of miRNA/siRNA targets, and the identification of mutations and editing sites in miRNAs. The book introduces basic ideas of computational methods, along with their detailed computational steps, a critical component in the development of high throughput sequencing technologies for identifying different classes of non-coding RNAs and predicting the possible functions of these molecules. Finding, quantifying, and visualizing non-coding RNAs from high throughput sequencing datasets at high volume is complex. Therefore, it is usually possible for biologists to complete all of the necessary steps for analysis. Presents a comprehensive resource of computational methods for the identification and quantification of non-coding RNAs Introduces 23 practical computational pipelines for various topics of non-coding RNAs Provides a guide to assist biologists and other researchers dealing with complex datasets Introduces basic computational methods and provides guidelines for their replication by researchers Offers a solution to researchers approaching large and complex sequencing datasets

Computational Biology of Non Coding RNA

Computational Biology of Non Coding RNA Book
Author : Xin Lai,Shailendra K. Gupta,Julio Vera
Publisher : Humana Press
Release : 2019-02-04
ISBN : 9781493989812
Language : En, Es, Fr & De

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Book Description :

This volume details a collection of state-of-art methods including identification of novel ncRNAs and their targets, functional annotation and disease association in different biological contexts. Chapters guide readers through an overview of disease-specific ncRNAs, computational methods and workflows for ncRNA discovery, annotation based on high-throughput sequencing data, bioinformatics tools and databases for ncRNA analyses, network-based methods, and kinetic modelling of ncRNA-mediated gene regulation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Biology of Non-Coding RNA: Methods and Protocols aims to provide a state-of-the-art collection of computational methods and approaches that will be of value to researchers interested in ncRNA field.

The Chemical Biology of Long Noncoding RNAs

The Chemical Biology of Long Noncoding RNAs Book
Author : Stefan Jurga,Jan Barciszewski
Publisher : Springer
Release : 2020-10-24
ISBN : 9783030447427
Language : En, Es, Fr & De

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Book Description :

This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.

Long Non Coding Rnas Methods and Protocols

Long Non Coding Rnas  Methods and Protocols Book
Author : Yi Feng,Lin Zhang
Publisher : Methods in Molecular Biology
Release : 2018-04-15
ISBN : 9781493980352
Language : En, Es, Fr & De

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Book Description :

This volume assembles a broad spectrum of methods used in long non-coding RNAs (lncRNA) research, ranging from computational annotation of lncRNA genes to molecular and cellular analyses of the function of individual lncRNA. Long Non-Coding RNAs: Methods and Protocols also discusses methods used to study circular RNAs and RNA splicing, as well as influential findings on lncRNA in human diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Long Non-Coding RNAs: Methods and Protocols is a must-have for molecular biologists, cell and developmental biologists, specialists who conduct disease-oriented research, and bioinformatics experts who seek a better understanding on lncRNA expression and function by computational analysis of the massive sequencing data that are rapidly accumulating in recent years.

Computational Methods for Genome wide Non coding RNA Discovery and Analysis

Computational Methods for Genome wide Non coding RNA Discovery and Analysis Book
Author : Shaojie Zhang
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The discovery of novel non-coding RNAs has been among the most exciting recent developments in Biology, yet, many more remain undiscovered. It has been hypothesized that there is in fact an abundance of functional non-coding RNAs (ncRNAs) with various catalytic and regulatory functions. Computational methods tailored specifically for ncRNA discovery are being actively developed. As the inherent signal for ncRNA is weaker than that for protein coding genes, comparative methods offer the most promising approach. In this dissertation, we address several open issues and problems on computational methods for genome wide non-coding RNA discovery and analysis: (1) We first consider the following problem: Given an RNA sequence with a known secondary structure, efficiently detect all structural homologs in a genomic database by computing the sequence and structure similarity to the query. Our approach, based on structural filters that eliminate a large portion of the database, while retaining the true homologs, allows us to search a typical bacterial genome in minutes on a standard PC. This results is two orders of magnitude better than currently available software for the problem. (2) We formalize the concept of a filter and provide figures of merit that allow comparison between filters. We design efficient sequence based filters that dominate the current state-of-the-art HMM filters. We provide a new formulation of the covariance model that allows speeding up RNA alignment. We demonstrate the power of our approach on both synthetic data and real bacterial genomes. We then apply our algorithm to the detection of novel riboswitch elements from the whole bacterial and archaeal genomes and environmental sequence data. Our results point to a number of novel riboswitch candidates, and include genomes that were not previously known to contain riboswitches. (3) We propose a novel framework to predict the common secondary structure for unaligned RNA sequences. By matching putative stacks in RNA sequences, we make use of both primary sequence information and thermodynamic stability for prediction at the same time. We show that our method can predict the correct common RNA secondary structures even when we are only given a limited number of unaligned RNA sequences, and it outperforms current algorithms in sensitivity and accuracy. Together these contributions made efforts toward genome wide ncRNA discovery for exploring the modern RNA world.

Bioinformatics of Non Coding RNAs with Applications to Biomedicine Recent Advances and Open Challenges

Bioinformatics of Non Coding RNAs with Applications to Biomedicine  Recent Advances and Open Challenges Book
Author : Carlo Maria Croce,Alfredo Ferro,Alessandro Laganà
Publisher : Frontiers Media SA
Release : 2017-01-27
ISBN : 2889450961
Language : En, Es, Fr & De

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Book Description :

The recent discovery of small and long non-coding RNAs (ncRNAs) has represented a major breakthrough in the life sciences. These molecules add a new layer of complexity to biological processes and pathways by revealing a sophisticated and dynamic interconnected system whose structure is just beginning to be uncovered. Genetic and epigenetic aberrations affecting ncRNA gene sequences and their expression have been linked to a variety of pathological conditions, including cancer, cardiovascular and neurological diseases. Latest advances in the development of high throughput analysis techniques may help to shed light on the complex regulatory mechanisms in which ncRNA molecules are involved. Bioinformatics tools constitute a unique and essential resource for non-coding RNA studies, providing a powerful technology to organize, integrate and analyze the huge amount of data produced daily by wet biology experiments in order to discover patterns, identify relationships among heterogeneous biological elements and formulate functional hypotheses. This Research Topic reviews current knowledge, introduces novel methods, and discusses open challenges of this exciting and innovative field in connection with the most important biomedical applications. It consists of four reviews and six original research and methods articles, spanning the full scope of the Research Topic.

Identification and Classification of Long Non Coding RNA in Zea Mays Using Computational and Bioinformatic Approaches

Identification and Classification of Long Non Coding RNA in Zea Mays Using Computational and Bioinformatic Approaches Book
Author : Susan Boerner
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

ABSTRACT: Computational analysis of cDNA sequences from multiple organisms suggests that a large portion of transcribed DNA does not code for a functional protein. As studies begin to delve into the possible functions of these noncoding transcripts, the results are revealing an ever more complex genome, where what was once dubbed "junk" is now seemingly necessary. The characterization of several long noncoding (lnc)RNAs in human and mouse has involved the analysis of raw genomic sequence data with a set of rules to computationally predict functional noncoding transcripts; other approaches involve expression datasets from microarray or RNAseq technology to achieve the same end. As these studies increase, the number of functions, classes and names, of noncoding transcripts increase as well. Many examples of lncRNAs appear to have an epigenetic role in humans, including HOTAIR and XIST. While epigenetic gene regulation is clearly an essential mechanism in plants, relatively little is known about the presence or function of lncRNAs in plants. To explore the connection between lncRNA and epigenetic regulation of gene expression in plants, a computational pipeline using the programming language Python that will identify, classify, and localize potential lncRNAs has been developed and applied to maize full length cDNA sequences. This analysis revealed that a large portion of transcribed sequences in maize are not predicted to be coding. In addition, over half of the predicted noncoding transcripts contain small RNA sequences. Also, approximately half of the predicted noncoding transcripts are associated with a gene model. Of these, roughly 20 percent are antisense to their host gene loci. Sequence analysis identified a GA rich motif that is similar to two known motifs in previously charatercterized lncRNAs, roX2 and HOTAIR. Overall these results suggest that lncRNAs may be a component of genome regulation in maize.

Regulatory RNAs

Regulatory RNAs Book
Author : Bibekanand Mallick,Zhumur Ghosh
Publisher : Springer
Release : 2012-02-05
ISBN : 9783642225185
Language : En, Es, Fr & De

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Book Description :

Recent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in the regulation of important cellular functions at the transcriptional and/or post-transcriptional levels rather than simply being an intermediated messenger between DNA and proteins. As the appreciation for the importance of ncRNAs continues to emerge, it is also increasingly clear that these play critical roles in gene regulatory processes during development and differentiation. Further, regulatory RNAs are useful biomarkers for diagnosis of diseases. Hence these RNA regulators are essential to the development of therapeutics. This book on “Regulatory RNAs” offers a comprehensive view on our current understanding of these regulatory RNAs viz. siRNA, miRNA, piRNA, snoRNA, long non-coding RNA, small RNA etc. It addresses both the biogenesis and mechanism of action of regulatory RNAs with a primary focus on their annotation, experimental methodologies (microarray, next-gen sequencing etc.) for their discovery, computational tools for their prediction, and above all, applications of these revolutionary regulatory molecules in understanding biological systems and diseases, including therapeutics. This comprehensive volume is intended for readers with research or teaching interests in ncRNA biology and will provide a major information resource on current research in the fast-moving fields of RNA and gene expression regulation. Cutting-edge and concise, “Regulatory RNAs: Basics, Methods and Applications” promises to support vital research in the field of regulatory RNAs, ever-continuing to grow rapidly and gain increasing importance in basic and translational biology.

Computational Biology and Bioinformatics

Computational Biology and Bioinformatics Book
Author : Ka-Chun Wong
Publisher : CRC Press
Release : 2016-04-27
ISBN : 1498725007
Language : En, Es, Fr & De

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Book Description :

The advances in biotechnology such as the next generation sequencing technologies are occurring at breathtaking speed. Advances and breakthroughs give competitive advantages to those who are prepared. However, the driving force behind the positive competition is not only limited to the technological advancement, but also to the companion data analytical skills and computational methods which are collectively called computational biology and bioinformatics. Without them, the biotechnology-output data by itself is raw and perhaps meaningless. To raise such awareness, we have collected the state-of-the-art research works in computational biology and bioinformatics with a thematic focus on gene regulation in this book. This book is designed to be self-contained and comprehensive, targeting senior undergraduates and junior graduate students in the related disciplines such as bioinformatics, computational biology, biostatistics, genome science, computer science, applied data mining, applied machine learning, life science, biomedical science, and genetics. In addition, we believe that this book will serve as a useful reference for both bioinformaticians and computational biologists in the post-genomic era.

Computational Systems Bioinformatics

Computational Systems Bioinformatics Book
Author : Peter Markstein,Ying Xu
Publisher : Imperial College Press
Release : 2006
ISBN : 1860947573
Language : En, Es, Fr & De

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Book Description :

This volume contains about 40 papers covering many of the latest developments in the fast-growing field of bioinformatics. The contributions span a wide range of topics, including computational genomics and genetics, protein function and computational proteomics, the transcriptome, structural bioinformatics, microarray data analysis, motif identification, biological pathways and systems, and biomedical applications. There are also abstracts from the keynote addresses and invited talks. The papers cover not only theoretical aspects of bioinformatics but also delve into the application of new methods, with input from computation, engineering and biology disciplines. This multidisciplinary approach to bioinformatics gives these proceedings a unique viewpoint of the field. Sample Chapter(s). Chapter 1: Exploring the Ocean''s Microbes: Sequencing the Seven Seas (122 KB). Contents: Exploring the Ocean''s Microbes: Sequencing the Seven Seas (M E Frazier et al.); Protein Network Comparative Genomics (T Ideker); Bioinformatics at Microsoft Research (S Mercer); Protein Fold Recognition Using Gradient Boost Algorithm (F Jiao et al.); Efficient Annotation of Non-Coding RNA Structures Including Pseudoknots via Automated Filters (C Liu et al.); Efficient Generalized Matrix Approximations for Biomarker Discovery and Visualization in Gene Expression Data (W Li et al.); Sorting Genomes by Translocations and Deletions (X Qi et al.); Detection of Cleavage Sites for HIV-1 Protease in Native Proteins (L You); Identifying Biological Pathways via Phase Decomposition and Profile Extraction (Y Zhang & Z Deng); Complexity and Scoring Function of MS/MS Peptide De Novo Sequencing (C Xu & B Ma); Simulating In Vitro Epithelial Morphogenesis in Multiple Environments (M R Grant et al.); and other papers. Readership: Research and application community in bioinformatics, systems biology, medicine, pharmacology and biotechnology. A useful reference for graduate researchers in bioinformatics and computational biology.

RNA Methodologies

RNA Methodologies Book
Author : Robert E. Farrell, Jr.
Publisher : Elsevier Health Sciences
Release : 2022-05
ISBN : 9780323902212
Language : En, Es, Fr & De

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Book Description :

RNA Methodologies: A Laboratory Guide for Isolation and Characterization, Sixth Edition continues its tradition of excellence in providing the most up-to-date ribonucleic acid lab techniques for seasoned scientists and graduate students alike. This edition features new material on RNA sequencing, RNA in Situ Hybridization, non-coding RNAs, computational RNA biology, transcriptomes and bioinformatics, with the latest advances in methods and protocols across the field of RNA investigation. As a leader in the field, Dr. Farrell provides a wealth of knowledge on the topic of RNA biology while also giving readers helpful hints and troubleshooting from his own personal experience in this subject area. RNA Methodologies, Sixth Edition, presents the essential knowledge and techniques to use when working with RNA for the experienced practitioner, while also aiding the beginner in fully understanding this important branch of molecular biology. This comprehensive updated edition equips the next generation of scientists with cutting-edge techniques the latest methodologies, and key information for their own laboratory work and study in this ever-changing and exciting field.

Molecular Biology of Long Non coding RNAs

Molecular Biology of Long Non coding RNAs Book
Author : Ahmad M. Khalil,Jeff Coller
Publisher : Springer Science & Business Media
Release : 2013-09-20
ISBN : 1461486211
Language : En, Es, Fr & De

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Book Description :

​Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. ​So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA research has had several critical developments during that time. This book will consolidate these ideas and models to better examine the most important issues in lncRNA biology. This will include critical studies that have led to the discovery and annotation of lncRNAs in numerous species, and the molecular mechanisms for a few lncRNA that have begun to emerge.

Recent Progresses of Non Coding RNAs in Biological and Medical Research 2nd Edition

Recent Progresses of Non Coding RNAs in Biological and Medical Research  2nd Edition Book
Author : Yun Zheng,Philipp Kapranov
Publisher : Frontiers Media SA
Release : 2020-11-04
ISBN : 2889660540
Language : En, Es, Fr & De

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Book Description :

Publisher’s note: In this 2nd edition, the following article has been updated: Xun Y, Tang Y, Hu L, Xiao H, Long S, Gong M, Wei C, Wei K and Xiang S (2019) Purification and Identification of miRNA Target Sites in Genome Using DNA Affinity Precipitation. Front. Genet. 10:778. doi: 10.3389/fgene.2019.00778

Regulatory RNAs

Regulatory RNAs Book
Author : Bibekanand Mallick,Zhumur Ghosh
Publisher : Springer Science & Business Media
Release : 2012-02-01
ISBN : 3642225179
Language : En, Es, Fr & De

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Book Description :

Recent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in the regulation of important cellular functions at the transcriptional and/or post-transcriptional levels rather than simply being an intermediated messenger between DNA and proteins. As the appreciation for the importance of ncRNAs continues to emerge, it is also increasingly clear that these play critical roles in gene regulatory processes during development and differentiation. Further, regulatory RNAs are useful biomarkers for diagnosis of diseases. Hence these RNA regulators are essential to the development of therapeutics. This book on “Regulatory RNAs” offers a comprehensive view on our current understanding of these regulatory RNAs viz. siRNA, miRNA, piRNA, snoRNA, long non-coding RNA, small RNA etc. It addresses both the biogenesis and mechanism of action of regulatory RNAs with a primary focus on their annotation, experimental methodologies (microarray, next-gen sequencing etc.) for their discovery, computational tools for their prediction, and above all, applications of these revolutionary regulatory molecules in understanding biological systems and diseases, including therapeutics. This comprehensive volume is intended for readers with research or teaching interests in ncRNA biology and will provide a major information resource on current research in the fast-moving fields of RNA and gene expression regulation. Cutting-edge and concise, “Regulatory RNAs: Basics, Methods and Applications” promises to support vital research in the field of regulatory RNAs, ever-continuing to grow rapidly and gain increasing importance in basic and translational biology.

Encyclopedia of Bioinformatics and Computational Biology

Encyclopedia of Bioinformatics and Computational Biology Book
Author : Anonim
Publisher : Elsevier
Release : 2018-08-21
ISBN : 0128114320
Language : En, Es, Fr & De

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Book Description :

Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases

Transactions on Computational Systems Biology X

Transactions on Computational Systems Biology X Book
Author : Corrado Priami,Falko Dressler,Ozgur B. Akan,Alioune Ngom
Publisher : Springer
Release : 2010-06-27
ISBN : 3540922733
Language : En, Es, Fr & De

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Book Description :

Technology is taking us to a world where myriads of heavily networked devices interact with the physical world in multiple ways, and at many levels, from the globalInternetdowntomicroandnanodevices. Manyofthesedevicesarehighly mobile and autonomous and must adapt to the surrounding environment in a totally unsupervised way. A fundamental research challenge is the design of robust decentralized c- puting systemsthat arecapableofoperating in changing environmentsandwith noisy input, and yet exhibit the desired behavior and response time, under c- straints such as energy consumption, size, and processing power. These systems should be able to adapt and learn how to react to unforeseen scenarios as well as to display properties comparable to social entities. The observation of nature has brought us many great and unforeseen concepts. Biological systems are able to handle many of these challenges with an elegance and e?ciency far beyond currenthumanartifacts. Basedonthisobservation,bio-inspiredapproacheshave been proposed as a means of handling the complexity of such systems. The goal is to obtain methods to engineer technical systems, which are of a stability and e?ciency comparable to those found in biological entities. This Special Issue on Biological and Biologically-inspired Communication contains the best papers from the Second International Conference on Bio- Inspired Models of Network, Information, and Computing Systems (BIONET- ICS 2007). The BIONETICS conference aims to bring together researchers and scientistsfromseveraldisciplines incomputerscienceandengineeringwhereb- inspired methods are investigated, as well as from bioinformatics, to deepen the information exchange and collaboration among the di?erent communities.

Computational Methods for Understanding Bacterial and Archaeal Genomes

Computational Methods for Understanding Bacterial and Archaeal Genomes Book
Author : Ying Xu
Publisher : Imperial College Press
Release : 2008
ISBN : 1860949835
Language : En, Es, Fr & De

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Book Description :

Over 500 prokaryotic genomes have been sequenced to date, and thousands more have been planned for the next few years. While these genomic sequence data provide unprecedented opportunities for biologists to study the world of prokaryotes, they also raise extremely challenging issues such as how to decode the rich information encoded in these genomes. This comprehensive volume includes a collection of cohesively written chapters on prokaryotic genomes, their organization and evolution, the information they encode, and the computational approaches needed to derive such information. A comparative view of bacterial and archaeal genomes, and how information is encoded differently in them, is also presented. Combining theoretical discussions and computational techniques, the book serves as a valuable introductory textbook for graduate-level microbial genomics and informatics courses.

Long Non Coding RNA Biology

Long Non Coding RNA Biology Book
Author : M.R.S. Rao
Publisher : Springer
Release : 2017-08-16
ISBN : 9811052034
Language : En, Es, Fr & De

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Book Description :

This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.

Advances in Bioinformatics and Computational Biology

Advances in Bioinformatics and Computational Biology Book
Author : Katia S. Guimarães,Anna Panchenko,Teresa M. Przytycka
Publisher : Springer Science & Business Media
Release : 2009-07-30
ISBN : 3642032230
Language : En, Es, Fr & De

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Book Description :

This volume contains the papers selected for presentation at the 4th Brazilian Sym- sium on Bioinformatics, BSB 2009, which was held in Porto Alegre, Brazil, during August 29–31, 2009. The BSB symposium had its origins in the Brazilian Workshop on Bioinformatics (WOB). WOB had three editions, in 2002 (Gramado, RS), in 2003 (Macaé, RJ), and in 2004 (Brasília, DF). The change in the designation from wo- shop to symposium reflects the increase in the quality of the contributions and also in the interest of the scientific community for the meeting. The previous editions of BSB took place in São Leopoldo, RS, in 2005, in Angra dos Reis, RJ, in 2007, and in Santo André, SP, in 2008. As evidence of the internationalization of the event, BSB 2009 had 55 submissions from seven countries. Of the 55 papers submitted, 36 were full papers, with up to 12 pages each, and 19 were extended abstracts, with up to 4 pages each. The articles submitted were carefully reviewed and selected by an international Program Comm- tee, comprising three chairs and 45 members from around the world, with the help of 21 additional reviewers. The Program Committee Chairs are very thankful to the - thors of all submitted papers, and especially to the Program Committee members and the additional reviewers, who helped select the 12 full papers and the six extended abstracts that make up this book.