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Computational Neuroscience In Epilepsy

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Computational Neuroscience in Epilepsy

Computational Neuroscience in Epilepsy Book
Author : Ivan Soltesz,Kevin Staley
Publisher : Academic Press
Release : 2011-09-02
ISBN : 9780080559537
Language : En, Es, Fr & De

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Book Description :

Epilepsy is a neurological disorder that affects millions of patients worldwide and arises from the concurrent action of multiple pathophysiological processes. The power of mathematical analysis and computational modeling is increasingly utilized in basic and clinical epilepsy research to better understand the relative importance of the multi-faceted, seizure-related changes taking place in the brain during an epileptic seizure. This groundbreaking book is designed to synthesize the current ideas and future directions of the emerging discipline of computational epilepsy research. Chapters address relevant basic questions (e.g., neuronal gain control) as well as long-standing, critically important clinical challenges (e.g., seizure prediction). Computational Neuroscience in Epilepsy should be of high interest to a wide range of readers, including undergraduate and graduate students, postdoctoral fellows and faculty working in the fields of basic or clinical neuroscience, epilepsy research, computational modeling and bioengineering. Covers a wide range of topics from molecular to seizure predictions and brain implants to control seizures Contributors are top experts at the forefront of computational epilepsy research Chapter contents are highly relevant to both basic and clinical epilepsy researchers

From Computer to Brain

From Computer to Brain Book
Author : William W. Lytton
Publisher : Springer Science & Business Media
Release : 2002-10-01
ISBN : 9780387955261
Language : En, Es, Fr & De

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Book Description :

Biology undergraduates, medical students and life-science graduate students often have limited mathematical skills. Similarly, physics, math and engineering students have little patience for the detailed facts that make up much of biological knowledge. Teaching computational neuroscience as an integrated discipline requires that both groups be brought forward onto common ground. This book does this by making ancillary material available in an appendix and providing basic explanations without becoming bogged down in unnecessary details. The book will be suitable for undergraduates and beginning graduate students taking a computational neuroscience course and also to anyone with an interest in the uses of the computer in modeling the nervous system.

Neuronal Substrates of Sleep and Epilepsy

Neuronal Substrates of Sleep and Epilepsy Book
Author : Mircea Steriade
Publisher : Cambridge University Press
Release : 2003-05-08
ISBN : 9780521817073
Language : En, Es, Fr & De

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Book Description :

Different states of vigilance and various paroxysmal disorders that occur during slow-wave sleep can have the same neural bases. Conventional wisdom holds that sleep is a resting state of the brain, with negligible activity of cortical neurons. Here, the author brings new evidence favoring the idea that during this behavioral state memory traces acquired during waking are consolidated. The author focuses on the coalescence of different sleep rhythms in interacting corticothalamic networks and on three types of paroxysmal disorders, namely spike-wave seizures as in absence epilepsy, Lennox-Gastaut seizures, and temporal-lobe epilepsy. Many physiological correlates of waking and sleep states as well as diverse types of epileptic seizures are also discussed. The book has copious illustrations with examples from in vivo, in vitro and 'in computo' studies, the majority coming from the author's own laboratory. Neuronal Substrates of Sleep and Epilepsy is essential reading for neuroscientists and clinical researchers.

Computational Neurology and Psychiatry

Computational Neurology and Psychiatry Book
Author : Péter Érdi,Basabdatta Sen Bhattacharya,Amy L. Cochran
Publisher : Springer
Release : 2017-01-25
ISBN : 3319499599
Language : En, Es, Fr & De

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Book Description :

This book presents the latest research in computational methods for modeling and simulating brain disorders. In particular, it shows how mathematical models can be used to study the relationship between a given disorder and the specific brain structure associated with that disorder. It also describes the emerging field of computational psychiatry, including the study of pathological behavior due to impaired functional connectivity, pathophysiological activity, and/or aberrant decision-making. Further, it discusses the data analysis techniques that will be required to analyze the increasing amount of data being generated about the brain. Lastly, the book offers some tips on the application of computational models in the field of quantitative systems pharmacology. Mainly written for computational scientists eager to discover new application fields for their model, this book also benefits neurologists and psychiatrists wanting to learn about new methods.

Computational Neuroscience

Computational Neuroscience Book
Author : James M. Bower
Publisher : Springer Science & Business Media
Release : 2013-06-29
ISBN : 1475798008
Language : En, Es, Fr & De

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Book Description :

This volume includes papers presented at the Fifth Annual Computational Neurosci ence meeting (CNS*96) held in Boston, Massachusetts, July 14 - 17, 1996. This collection includes 148 of the 234 papers presented at the meeting. Acceptance for mceting presenta tion was based on the peer review of preliminary papers originally submitted in May of 1996. The papers in this volume represent final versions of this work submitted in January of 1997. As represented by this volume, computational neuroscience continues to expand in quality, size and breadth of focus as increasing numbers of neuroscientists are taking a computational approach to understanding nervous system function. Defining computa tional neuroscience as the exploration of how brains compute, it is clear that there is al most no subject or area of modern neuroscience research that is not appropriate for computational studies. The CNS meetings as well as this volume reflect this scope and di versity.

Computational Neuroscience

Computational Neuroscience Book
Author : Vinícius Rosa Cota,Dante Augusto Couto Barone,Diego Roberto Colombo Dias,Laila Cristina Moreira Damázio
Publisher : Springer Nature
Release : 2019-11-28
ISBN : 3030366367
Language : En, Es, Fr & De

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Book Description :

This book constitutes the thoroughly refereed proceedings of the Second International Workshop of Computational Neuroscience, held in São João Del-Rei, Brazil, in September 2019. The 17 full papers and 3 short papers presented have been thoroughly reviewed and selected from 45 submissions. The papers are organized in topical sections: artificial intelligence, machine learning, and related topics; complex systems and complex networks; computational neuroscience of learning and memory; neural signal processing; software and hardware implementations in neuroscience; brain-machine interfaces and neurostimulation; and seizure prediction.

Bundle for Epilepsy Researchers

Bundle for Epilepsy Researchers Book
Author : Ruben Kuzniecky,Asla Pitknen,Ivan Soltesz
Publisher : Academic Press
Release : 2008-10-03
ISBN : 9780123748690
Language : En, Es, Fr & De

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Book Description :

Combining three essential Academic Press books, this bundle provides reference information for epilepsy researchers at a great price. Magnetic Resonance in Epilepsy is an in-depth look at the advances in imaging techology as applied to epilepsy research. Models of Seizures and Epilepsy speaks to the needs of both basic neuroscientists and clinical neurologists, in understanding the pathophysiology of seizures and the epilepsies and predicting the clinical effectiveness of antiepileptic treatments. Computational Neuroscience in Epilepsy is the first-ever book solely dedicated to the emerging discipline of computational epilepsy research.

Epilepsy

Epilepsy Book
Author : Ivan Osorio,Hitten P. Zaveri,Mark G. Frei,Susan Arthurs
Publisher : CRC Press
Release : 2016-04-19
ISBN : 9781439838860
Language : En, Es, Fr & De

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Book Description :

Epilepsy, one of the most prevalent neurological disorders, affects approximately 1% (greater than 60 million) of the world's population. In an estimated 20 million of these patients, seizures are not controlled even by multiple anti-seizure drugs, and are extremely difficult to predict. Epilepsy: The Intersection of Neurosciences, Biology, Mathematics, Engineering, and Physics seamlessly brings together the neurosciences, mathematics, computational sciences, engineering, physics, and clinical epileptology to present to readers a highly didactic, integrated, clear and practically useful knowledge base and research directions. Laying out the foundations of signal analysis, data conditioning, linear and non-linear analysis, introduction to dynamical systems and fundamental anatomical and neurophysiological concepts, this book: Introduces non-physicians to language and concepts necessary to establish a meaningful dialog with epileptologists Introduces physicians to dynamical theory and signal processing without which interdisciplinary collaborations would not be productive Mines knowledge from fields devoted to the investigation of aperiodic paroxysmal relaxation phenomena, such as earthquakes, which bear dynamical similarities with epilepsy, so as to lay the proper scientific foundations for epileptology and foster much needed therapeutic advances efficiently Reviews spatiotemporal behavior of seizures, mechanisms of epileptogenesis and ictogenesis as well as of seizure control and ancillary technology Calls attention to nocturnal frontal lobe epilepsy as a potentially fruitful paradigm for advancing seizure prediction. Of all neurological disorders, epilepsy demands of investigators the broadest and deepest knowledge of dynamical, control, and system theories, knowledge that cannot be amassed without possessing a certain level of sophistication in relevant areas of neurosciences, physics, mathematics, and engineering. Narrowing the inescapable cultural chasm that commonly fragments multidisciplinary efforts, this book captures and enriches the burgeoning interdisciplinary synergism in the nascent field of dynamical epileptology.

From Neuron to Cognition via Computational Neuroscience

From Neuron to Cognition via Computational Neuroscience Book
Author : Michael A. Arbib,James J. Bonaiuto
Publisher : MIT Press
Release : 2016-11-04
ISBN : 0262335271
Language : En, Es, Fr & De

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Book Description :

A comprehensive, integrated, and accessible textbook presenting core neuroscientific topics from a computational perspective, tracing a path from cells and circuits to behavior and cognition. This textbook presents a wide range of subjects in neuroscience from a computational perspective. It offers a comprehensive, integrated introduction to core topics, using computational tools to trace a path from neurons and circuits to behavior and cognition. Moreover, the chapters show how computational neuroscience—methods for modeling the causal interactions underlying neural systems—complements empirical research in advancing the understanding of brain and behavior. The chapters—all by leaders in the field, and carefully integrated by the editors—cover such subjects as action and motor control; neuroplasticity, neuromodulation, and reinforcement learning; vision; and language—the core of human cognition. The book can be used for advanced undergraduate or graduate level courses. It presents all necessary background in neuroscience beyond basic facts about neurons and synapses and general ideas about the structure and function of the human brain. Students should be familiar with differential equations and probability theory, and be able to pick up the basics of programming in MATLAB and/or Python. Slides, exercises, and other ancillary materials are freely available online, and many of the models described in the chapters are documented in the brain operation database, BODB (which is also described in a book chapter). Contributors Michael A. Arbib, Joseph Ayers, James Bednar, Andrej Bicanski, James J. Bonaiuto, Nicolas Brunel, Jean-Marie Cabelguen, Carmen Canavier, Angelo Cangelosi, Richard P. Cooper, Carlos R. Cortes, Nathaniel Daw, Paul Dean, Peter Ford Dominey, Pierre Enel, Jean-Marc Fellous, Stefano Fusi, Wulfram Gerstner, Frank Grasso, Jacqueline A. Griego, Ziad M. Hafed, Michael E. Hasselmo, Auke Ijspeert, Stephanie Jones, Daniel Kersten, Jeremie Knuesel, Owen Lewis, William W. Lytton, Tomaso Poggio, John Porrill, Tony J. Prescott, John Rinzel, Edmund Rolls, Jonathan Rubin, Nicolas Schweighofer, Mohamed A. Sherif, Malle A. Tagamets, Paul F. M. J. Verschure, Nathan Vierling-Claasen, Xiao-Jing Wang, Christopher Williams, Ransom Winder, Alan L. Yuille

Computational Neuroscience

Computational Neuroscience Book
Author : Wanpracha Chaovalitwongse,Panos M. Pardalos,Petros Xanthopoulos
Publisher : Springer Science & Business Media
Release : 2010-07-03
ISBN : 9780387886305
Language : En, Es, Fr & De

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Book Description :

This volume includes contributions from diverse disciplines including electrical engineering, biomedical engineering, industrial engineering, and medicine, bridging a vital gap between the mathematical sciences and neuroscience research. Covering a wide range of research topics, this volume demonstrates how various methods from data mining, signal processing, optimization and cutting-edge medical techniques can be used to tackle the most challenging problems in modern neuroscience.

Oxford Textbook of Epilepsy and Epileptic Seizures

Oxford Textbook of Epilepsy and Epileptic Seizures Book
Author : Simon Shorvon,Renzo Guerrini,Mark Cook,Samden Lhatoo
Publisher : OUP Oxford
Release : 2012-12-20
ISBN : 0191640964
Language : En, Es, Fr & De

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Book Description :

Epilepsy is the most common serious neurological condition, affecting children and adults, and can occur in a variety of medical settings. It has many causes and many forms, and a variable prognosis. Mortality and morbidity are high, social and legal consequences can stretch well beyond the purely medical, and its management is often poor. Part of the Oxford Textbooks in Clinical Neurology (OTCN) series, this volume covers the scientific basis, clinical diagnosis, and treatment of epilepsy and epileptic seizures. Written by internationally-renowned specialists, each chapter comprehensively covers the current knowledge and evidence base related to each aspect of the disorder, with an emphasis on the personal experience of the authors. The print edition of the Oxford Textbook of Epilepsy and Epileptic Seizures is complemented by an online version, which allows access to the full content of the textbook, contains links from the references to primary research journal articles, enables full text searches, and provides access to figures and tables that can be downloaded to PowerPoint®. This textbook will prove a useful clinical reference for neurologists and senior trainees in neurology, an educational manual for trainees, and will offer practical assistance to all physicians advising people with epilepsy.

Seizure Prediction in Epilepsy

Seizure Prediction in Epilepsy Book
Author : Björn Schelter,Jens Timmer,Andreas Schulze-Bonhage
Publisher : John Wiley & Sons
Release : 2008-11-21
ISBN : 3527625208
Language : En, Es, Fr & De

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Book Description :

Comprising some 30 contributions, experts from around the world present and discuss recent advances related to seizure prediction in epilepsy. The book covers an extraordinarily broad spectrum, starting from modeling epilepsy in single cells or networks of a few cells to precisely-tailored seizure prediction techniques as applied to human data. This unique overview of our current level of knowledge and future perspectives provides theoreticians as well as practitioners, newcomers and experts with an up-to-date survey of developments in this important field of research.

Computational Models of Brain and Behavior

Computational Models of Brain and Behavior Book
Author : Ahmed A. Moustafa
Publisher : John Wiley & Sons
Release : 2017-11-13
ISBN : 1119159067
Language : En, Es, Fr & De

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Book Description :

A comprehensive Introduction to the world of brain and behavior computational models This book provides a broad collection of articles covering different aspects of computational modeling efforts in psychology and neuroscience. Specifically, it discusses models that span different brain regions (hippocampus, amygdala, basal ganglia, visual cortex), different species (humans, rats, fruit flies), and different modeling methods (neural network, Bayesian, reinforcement learning, data fitting, and Hodgkin-Huxley models, among others). Computational Models of Brain and Behavior is divided into four sections: (a) Models of brain disorders; (b) Neural models of behavioral processes; (c) Models of neural processes, brain regions and neurotransmitters, and (d) Neural modeling approaches. It provides in-depth coverage of models of psychiatric disorders, including depression, posttraumatic stress disorder (PTSD), schizophrenia, and dyslexia; models of neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and epilepsy; early sensory and perceptual processes; models of olfaction; higher/systems level models and low-level models; Pavlovian and instrumental conditioning; linking information theory to neurobiology; and more. Covers computational approximations to intellectual disability in down syndrome Discusses computational models of pharmacological and immunological treatment in Alzheimer's disease Examines neural circuit models of serotonergic system (from microcircuits to cognition) Educates on information theory, memory, prediction, and timing in associative learning Computational Models of Brain and Behavior is written for advanced undergraduate, Master's and PhD-level students—as well as researchers involved in computational neuroscience modeling research.

Epilepsy An Issue of Neurosurgery Clinics E Book

Epilepsy  An Issue of Neurosurgery Clinics   E Book Book
Author : Edward F. Chang,Nicholas Barbaro
Publisher : Elsevier Health Sciences
Release : 2011-10-18
ISBN : 1455712140
Language : En, Es, Fr & De

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Book Description :

In this issue of Neurosurgery Clinics, Drs. Chang and Barbaro provide a thorough look at epilepsy, with sections focusing on devices in epilepsy surgery, open loop systems, closed loop systems, and non-stimulation. Topics in this issue include history and overview of stimulation for epilepsy, trigeminal nerve stimulation, anterior thalamus DBS, hippocampal stimulation, neuropace RNS, seizure detection/prediction algorithms, cooling, seizure prediction and its applications, stimulation paradigms, and experimental stimulation.

Behavioral Aspects of Epilepsy

Behavioral Aspects of Epilepsy Book
Author : Gregory L. Holmes, MD,Steven C. Schachter,Dr. Dorothee GA Kasteleijn-Nolst Trenite, "MD,MPH"
Publisher : Demos Medical Publishing
Release : 2007-10-15
ISBN : 9781934559888
Language : En, Es, Fr & De

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Book Description :

The field of epilepsy and behavior has grown considerably in the past number of years, reflecting advances in the laboratory and clinic. Behavioral Aspects of Epilepsy: Principles and Practice is the definitive text on epilepsy behavioral issues, from basic science to clinical applications, for all neurologists, psychosocial specialists, and researchers in the fields of epilepsy, neuroscience, and psychology/psychiatry. Behavioral aspects of epilepsy include a patient's experiences during seizures, his or her reaction during and between seizures, the frequency of episodes and what can be determined from the number of seizures. With contributions by dozens of leading international experts, this is the only book to cover all aspects of this critical emerging science. Adult and pediatric patients, animal models, and epilepsy surgery and its effects are all covered in detail. Behavioral Aspects of Epilepsy is the only source for up-to-date information on a topic that has significant and growing interest in the medical community. This comprehensive, authoritative text has a bench to bedside, approach that covers: The mechanisms underlying epilepsy and behavior Neurophysiologic function Neuropsychiatric and behavioral disorders in patients with epilepsy The effects of treatments and surgery on behavior Pediatric and adolescent epilepsy Disorders associated with epilepsy that impact behavior And much more

Biophysically based Computational Models of Astrocyte Neuron Coupling and their Functional Significance

Biophysically based Computational Models of Astrocyte   Neuron Coupling and their Functional Significance Book
Author : John Wade,Scott Kelso,Vincenzo Crunelli, Liam J. McDaid, Jim Harkin
Publisher : Frontiers E-books
Release : 2014-03-21
ISBN : 2889191788
Language : En, Es, Fr & De

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Book Description :

Neuroscientists are increasingly becoming more interested in modelling brain functions where capturing the biophysical mechanisms underpinning these functions requires plausible models at the level of neuron cells. However, cell level models are still very much in the embryo stage and therefore there is a need to advance the level of biological realism at the level of neurons/synapses. Recent publications have highlighted that astrocytes continually exchange information with multiple synapses; if we are to fully appreciate this dynamic and coordinated interplay between these cells then more research on bidirectional signalling between astrocytes and neurons is required. A better understanding of astrocyte-neuron cell coupling would provide the building block for studying the regulatory capability of astrocytes networks on a large scale. For example, it is believed that local and global signalling via astrocytes underpins brain functions like synchrony, learning, memory and self repair. This Research Topic aims to report on current research work which focuses on understanding and modelling the interaction between astrocytes and neurons at the cellular level (Bottom up) and at network level (Top down). Understanding astrocytic regulation of neural activity is crucial if we are to capture how information is represented and processed across large neuronal ensembles in humans.

Computational Neuroscience

Computational Neuroscience Book
Author : Jianfeng Feng
Publisher : CRC Press
Release : 2003-10-20
ISBN : 1135440468
Language : En, Es, Fr & De

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Book Description :

How does the brain work? After a century of research, we still lack a coherent view of how neurons process signals and control our activities. But as the field of computational neuroscience continues to evolve, we find that it provides a theoretical foundation and a set of technological approaches that can significantly enhance our understanding.

Computational Neuroscience Trends in Research 1999

Computational Neuroscience  Trends in Research 1999 Book
Author : J.M. Bower
Publisher : Elsevier
Release : 1999-07-22
ISBN : 9780444503077
Language : En, Es, Fr & De

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Book Description :

This volume includes papers originally presented at the 7th annual Computational Neuroscience Meeting (CNS'98) held in July of 1998 at the Fess Parker Doubletree Inn in Santa Barbara, California. The CNS meetings bring together computational neuroscientists representing many different fields and backgrounds as well as many different experimental preparations and theoretical approaches. The papers published here range from pure experimental neurobiology, to neuro-ethology, mathematics, physics, and engineering. In all cases the research described is focused on understanding how nervous systems compute. The actual subjects of the research include a highly diverse number of preparations, modeling approaches, and analysis techniques. Accordingly, this volume reflects the breadth and depth of current research in computational neuroscience taking place throughout the world.

Multiscale Models of Brain Disorders

Multiscale Models of Brain Disorders Book
Author : Vassilis Cutsuridis
Publisher : Springer Nature
Release : 2019-10-11
ISBN : 3030188302
Language : En, Es, Fr & De

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Book Description :

This book focuses on our current understanding of brain dynamics in various brain disorders (e.g. epilepsy, Alzheimer’s and Parkinson’s disease) and how the multi-scale, multi-level tools of computational neuroscience can enhance this understanding. In recent years, there have been significant advances in the study of the dynamics of the disordered brain at both the microscopic and the macroscopic levels. This understanding can be furthered by the application of multi-scale computational models as integrative principles that may link single neuron dynamics and the dynamics of local and distant brain regions observed using human EEG, ERPs, MEG, LFPs and fMRI. Focusing on the computational models that are used to study movement, memory and cognitive disorders as well as epilepsy and consciousness related diseases, the book brings together physiologists and anatomists investigating cortical circuits; cognitive neuroscientists studying brain dynamics and behavior by means of EEG and functional magnetic resonance imaging (fMRI); and computational neuroscientists using neural modeling techniques to explore local and large-scale disordered brain dynamics. Covering topics that have a significant impact on the field of medicine, neuroscience and computer science, the book appeals to a diverse group of investigators.