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Computational Neuroscience In Epilepsy

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Computational Neuroscience in Epilepsy

Computational Neuroscience in Epilepsy Book
Author : Ivan Soltesz,Kevin Staley
Publisher : Academic Press
Release : 2011-09-02
ISBN : 9780080559537
Language : En, Es, Fr & De

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Book Description :

Epilepsy is a neurological disorder that affects millions of patients worldwide and arises from the concurrent action of multiple pathophysiological processes. The power of mathematical analysis and computational modeling is increasingly utilized in basic and clinical epilepsy research to better understand the relative importance of the multi-faceted, seizure-related changes taking place in the brain during an epileptic seizure. This groundbreaking book is designed to synthesize the current ideas and future directions of the emerging discipline of computational epilepsy research. Chapters address relevant basic questions (e.g., neuronal gain control) as well as long-standing, critically important clinical challenges (e.g., seizure prediction). Computational Neuroscience in Epilepsy should be of high interest to a wide range of readers, including undergraduate and graduate students, postdoctoral fellows and faculty working in the fields of basic or clinical neuroscience, epilepsy research, computational modeling and bioengineering. Covers a wide range of topics from molecular to seizure predictions and brain implants to control seizures Contributors are top experts at the forefront of computational epilepsy research Chapter contents are highly relevant to both basic and clinical epilepsy researchers

Bundle for Epilepsy Researchers

Bundle for Epilepsy Researchers Book
Author : Ruben Kuzniecky,Asla Pitknen,Ivan Soltesz
Publisher : Academic Press
Release : 2008-10-03
ISBN : 9780123748690
Language : En, Es, Fr & De

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Book Description :

Combining three essential Academic Press books, this bundle provides reference information for epilepsy researchers at a great price. Magnetic Resonance in Epilepsy is an in-depth look at the advances in imaging techology as applied to epilepsy research. Models of Seizures and Epilepsy speaks to the needs of both basic neuroscientists and clinical neurologists, in understanding the pathophysiology of seizures and the epilepsies and predicting the clinical effectiveness of antiepileptic treatments. Computational Neuroscience in Epilepsy is the first-ever book solely dedicated to the emerging discipline of computational epilepsy research.

Epilepsy

Epilepsy Book
Author : Susan Arthurs
Publisher : CRC Press
Release : 2017-03-29
ISBN : 9781138074163
Language : En, Es, Fr & De

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Book Description :

Epilepsy, one of the most prevalent neurological disorders, affects approximately 1% (greater than 60 million) of the world's population. In an estimated 20 million of these patients, seizures are not controlled even by multiple anti-seizure drugs, and are extremely difficult to predict. Epilepsy: The Intersection of Neurosciences, Biology, Mathematics, Engineering, and Physics seamlessly brings together the neurosciences, mathematics, computational sciences, engineering, physics, and clinical epileptology to present to readers a highly didactic, integrated, clear and practically useful knowledge base and research directions. Laying out the foundations of signal analysis, data conditioning, linear and non-linear analysis, introduction to dynamical systems and fundamental anatomical and neurophysiological concepts, this book: Introduces non-physicians to language and concepts necessary to establish a meaningful dialog with epileptologists Introduces physicians to dynamical theory and signal processing without which interdisciplinary collaborations would not be productive Mines knowledge from fields devoted to the investigation of aperiodic paroxysmal relaxation phenomena, such as earthquakes, which bear dynamical similarities with epilepsy, so as to lay the proper scientific foundations for epileptology and foster much needed therapeutic advances efficiently Reviews spatiotemporal behavior of seizures, mechanisms of epileptogenesis and ictogenesis as well as of seizure control and ancillary technology Calls attention to nocturnal frontal lobe epilepsy as a potentially fruitful paradigm for advancing seizure prediction. Of all neurological disorders, epilepsy demands of investigators the broadest and deepest knowledge of dynamical, control, and system theories, knowledge that cannot be amassed without possessing a certain level of sophistication in relevant areas of neurosciences, physics, mathematics, and engineering. Narrowing the inescapable cultural chasm that commonly fragments multidisciplinary efforts, this book captures and enriches the burgeoning interdisciplinary synergism in the nascent field of dynamical epileptology.

Biocomputing

Biocomputing Book
Author : Panos M. Pardalos,J.C. Principe
Publisher : Springer Science & Business Media
Release : 2013-12-01
ISBN : 1461302595
Language : En, Es, Fr & De

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Book Description :

In the quest to understand and model the healthy or sick human body, re searchers and medical doctors are utilizing more and more quantitative tools and techniques. This trend is pushing the envelope of a new field we call Biomedical Computing, as an exciting frontier among signal processing, pattern recognition, optimization, nonlinear dynamics, computer science and biology, chemistry and medicine. A conference on Biocomputing was held during February 25-27, 2001 at the University of Florida. The conference was sponsored by the Center for Applied Optimization, the Computational Neuroengineering Center, the Biomedical En gineering Program (through a Whitaker Foundation grant), the Brain Institute, the School of Engineering, and the University of Florida Research & Graduate Programs. The conference provided a forum for researchers to discuss and present new directions in Biocomputing. The well-attended three days event was highlighted by the presence of top researchers in the field who presented their work in Biocomputing. This volume contains a selective collection of ref ereed papers based on talks presented at this conference. You will find seminal contributions in genomics, global optimization, computational neuroscience, FMRI, brain dynamics, epileptic seizure prediction and cancer diagnostics. We would like to take the opportunity to thank the sponsors, the authors of the papers, the anonymous referees, and Kluwer Academic Publishers for making the conference successful and the publication of this volume possible. Panos M. Pardalos and Jose C.

Multiscale Models of Brain Disorders

Multiscale Models of Brain Disorders Book
Author : Vassilis Cutsuridis
Publisher : Springer Nature
Release : 2019-10-11
ISBN : 3030188302
Language : En, Es, Fr & De

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Book Description :

This book focuses on our current understanding of brain dynamics in various brain disorders (e.g. epilepsy, Alzheimer’s and Parkinson’s disease) and how the multi-scale, multi-level tools of computational neuroscience can enhance this understanding. In recent years, there have been significant advances in the study of the dynamics of the disordered brain at both the microscopic and the macroscopic levels. This understanding can be furthered by the application of multi-scale computational models as integrative principles that may link single neuron dynamics and the dynamics of local and distant brain regions observed using human EEG, ERPs, MEG, LFPs and fMRI. Focusing on the computational models that are used to study movement, memory and cognitive disorders as well as epilepsy and consciousness related diseases, the book brings together physiologists and anatomists investigating cortical circuits; cognitive neuroscientists studying brain dynamics and behavior by means of EEG and functional magnetic resonance imaging (fMRI); and computational neuroscientists using neural modeling techniques to explore local and large-scale disordered brain dynamics. Covering topics that have a significant impact on the field of medicine, neuroscience and computer science, the book appeals to a diverse group of investigators.

Computational Neuroscience

Computational Neuroscience Book
Author : Vinícius Rosa Cota,Dante Augusto Couto Barone,Diego Roberto Colombo Dias,Laila Cristina Moreira Damázio
Publisher : Springer Nature
Release : 2019-11-28
ISBN : 3030366367
Language : En, Es, Fr & De

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Book Description :

This book constitutes the thoroughly refereed proceedings of the Second International Workshop of Computational Neuroscience, held in São João Del-Rei, Brazil, in September 2019. The 17 full papers and 3 short papers presented have been thoroughly reviewed and selected from 45 submissions. The papers are organized in topical sections: artificial intelligence, machine learning, and related topics; complex systems and complex networks; computational neuroscience of learning and memory; neural signal processing; software and hardware implementations in neuroscience; brain-machine interfaces and neurostimulation; and seizure prediction.

Nonlinear Dynamics in Computational Neuroscience

Nonlinear Dynamics in Computational Neuroscience Book
Author : Fernando Corinto,Alessandro Torcini
Publisher : Springer
Release : 2018-07-22
ISBN : 3319710486
Language : En, Es, Fr & De

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Book Description :

This book provides an essential overview of computational neuroscience. It addresses a broad range of aspects, from physiology to nonlinear dynamical approaches to understanding neural computation, and from the simulation of brain circuits to the development of engineering devices and platforms for neuromorphic computation. Written by leading experts in such diverse fields as neuroscience, physics, psychology, neural engineering, cognitive science and applied mathematics, the book reflects the remarkable advances that have been made in the field of computational neuroscience, an emerging discipline devoted to the study of brain functions in terms of the information-processing properties of the structures forming the nervous system. The content builds on the workshop “Nonlinear Dynamics in Computational Neuroscience: from Physics and Biology to ICT,” which was held in Torino, Italy in September 2015.

Hippocampal Microcircuits

Hippocampal Microcircuits Book
Author : Vassilis Cutsuridis,Bruce P. Graham,Stuart Cobb,Imre Vida
Publisher : Springer
Release : 2019-02-04
ISBN : 3319991035
Language : En, Es, Fr & De

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Book Description :

This is the 2nd edition of a very well received and popular book that reflects the current state-of-the-art of the ongoing research avenues concerning the hippocampus and processing units bridging the gap between single cell activity, network activity and global brain function. It aims to provide a methodology to anyone interested in developing microcircuit level models of the hippocampus. The book is divided into two thematic areas: (I) Experimental background and (II) Computational analysis. In part I, leading experimental neuroscientists discuss the morphological, physiological and molecular characteristics as well as the connectivity and synaptic properties of the various cell types found in the hippocampus. Behaviour-related ensemble activity patterns of morphologically identified neurons in anesthetized and freely moving animals provide insights on the function of the hippocampal areas. In part II, computational neuroscientists present models of the hippocampal microcircuits at various levels of detail (e.g. single cell level, network level, etc.). Synaptomics and connectomics models of hippocampal structures are initially discussed. Then, network models of memory, rhythm generation and spatial navigation are presented, followed by abstract and biophysical models of synaptic plasticity. Network models of hippocampal implicated disorders (epilepsy and schizophrenia) are then detailed and how their network topologies, connectivities and activities change in these diseases. Finally, two chapters are dedicated to describing simulator environments of single neurons and networks currently used by computational neuroscientists in developing their models and modelling tools to parametrically constrain them. This engaging volume is invaluable to experimental and computational neuroscientists, electrical engineers, physicists, mathematicians and others interested in developing microcircuit models of the hippocampus. Graduate level students and trainees in all of these fields can find this book a significant source of information.

Computational Neurology and Psychiatry

Computational Neurology and Psychiatry Book
Author : Péter Érdi,Basabdatta Sen Bhattacharya,Amy L. Cochran
Publisher : Springer
Release : 2017-01-25
ISBN : 3319499599
Language : En, Es, Fr & De

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Book Description :

This book presents the latest research in computational methods for modeling and simulating brain disorders. In particular, it shows how mathematical models can be used to study the relationship between a given disorder and the specific brain structure associated with that disorder. It also describes the emerging field of computational psychiatry, including the study of pathological behavior due to impaired functional connectivity, pathophysiological activity, and/or aberrant decision-making. Further, it discusses the data analysis techniques that will be required to analyze the increasing amount of data being generated about the brain. Lastly, the book offers some tips on the application of computational models in the field of quantitative systems pharmacology. Mainly written for computational scientists eager to discover new application fields for their model, this book also benefits neurologists and psychiatrists wanting to learn about new methods.

Computational Neuroscience

Computational Neuroscience Book
Author : James M. Bower
Publisher : Springer Science & Business Media
Release : 2013-06-29
ISBN : 1475798008
Language : En, Es, Fr & De

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Book Description :

This volume includes papers presented at the Fifth Annual Computational Neurosci ence meeting (CNS*96) held in Boston, Massachusetts, July 14 - 17, 1996. This collection includes 148 of the 234 papers presented at the meeting. Acceptance for mceting presenta tion was based on the peer review of preliminary papers originally submitted in May of 1996. The papers in this volume represent final versions of this work submitted in January of 1997. As represented by this volume, computational neuroscience continues to expand in quality, size and breadth of focus as increasing numbers of neuroscientists are taking a computational approach to understanding nervous system function. Defining computa tional neuroscience as the exploration of how brains compute, it is clear that there is al most no subject or area of modern neuroscience research that is not appropriate for computational studies. The CNS meetings as well as this volume reflect this scope and di versity.

Computational Neuroscience

Computational Neuroscience Book
Author : Wanpracha Chaovalitwongse,Panos M. Pardalos,Petros Xanthopoulos
Publisher : Springer Science & Business Media
Release : 2010-07-03
ISBN : 9780387886305
Language : En, Es, Fr & De

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Book Description :

This volume includes contributions from diverse disciplines including electrical engineering, biomedical engineering, industrial engineering, and medicine, bridging a vital gap between the mathematical sciences and neuroscience research. Covering a wide range of research topics, this volume demonstrates how various methods from data mining, signal processing, optimization and cutting-edge medical techniques can be used to tackle the most challenging problems in modern neuroscience.

Computational Neurogenetic Modeling

Computational Neurogenetic Modeling Book
Author : Lubica Benuskova,Nikola K. Kasabov
Publisher : Springer Science & Business Media
Release : 2010-05-05
ISBN : 9780387483559
Language : En, Es, Fr & De

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Book Description :

This is a student text, introducing the scope and problems of a new scientific discipline - Computational Neurogenetic Modeling (CNGM). CNGM is concerned with the study and development of dynamic neuronal models for modeling brain functions with respect to genes and dynamic interactions between genes. These include neural network models and their integration with gene network models. This new area brings together knowledge from various scientific disciplines.

Computational Models of Brain and Behavior

Computational Models of Brain and Behavior Book
Author : Ahmed A. Moustafa
Publisher : John Wiley & Sons
Release : 2017-09-18
ISBN : 1119159180
Language : En, Es, Fr & De

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Book Description :

A comprehensive Introduction to the world of brain and behavior computational models This book provides a broad collection of articles covering different aspects of computational modeling efforts in psychology and neuroscience. Specifically, it discusses models that span different brain regions (hippocampus, amygdala, basal ganglia, visual cortex), different species (humans, rats, fruit flies), and different modeling methods (neural network, Bayesian, reinforcement learning, data fitting, and Hodgkin-Huxley models, among others). Computational Models of Brain and Behavior is divided into four sections: (a) Models of brain disorders; (b) Neural models of behavioral processes; (c) Models of neural processes, brain regions and neurotransmitters, and (d) Neural modeling approaches. It provides in-depth coverage of models of psychiatric disorders, including depression, posttraumatic stress disorder (PTSD), schizophrenia, and dyslexia; models of neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and epilepsy; early sensory and perceptual processes; models of olfaction; higher/systems level models and low-level models; Pavlovian and instrumental conditioning; linking information theory to neurobiology; and more. Covers computational approximations to intellectual disability in down syndrome Discusses computational models of pharmacological and immunological treatment in Alzheimer's disease Examines neural circuit models of serotonergic system (from microcircuits to cognition) Educates on information theory, memory, prediction, and timing in associative learning Computational Models of Brain and Behavior is written for advanced undergraduate, Master's and PhD-level students—as well as researchers involved in computational neuroscience modeling research.

Signal Processing for Neuroscientists A Companion Volume

Signal Processing for Neuroscientists  A Companion Volume Book
Author : Wim van Drongelen
Publisher : Elsevier
Release : 2010-08-26
ISBN : 0123849160
Language : En, Es, Fr & De

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Book Description :

The popularity of signal processing in neuroscience is increasing, and with the current availability and development of computer hardware and software, it is anticipated that the current growth will continue. Because electrode fabrication has improved and measurement equipment is getting less expensive, electrophysiological measurements with large numbers of channels are now very common. In addition, neuroscience has entered the age of light, and fluorescence measurements are fully integrated into the researcher’s toolkit. Because each image in a movie contains multiple pixels, these measurements are multi-channel by nature. Furthermore, the availability of both generic and specialized software packages for data analysis has altered the neuroscientist’s attitude toward some of the more complex analysis techniques. This book is a companion to the previously published Signal Processing for Neuroscientists: An Introduction to the Analysis of Physiological Signals, which introduced readers to the basic concepts. It discusses several advanced techniques, rediscovers methods to describe nonlinear systems, and examines the analysis of multi-channel recordings. Covers the more advanced topics of linear and nonlinear systems analysis and multi-channel analysis Includes practical examples implemented in MATLAB Provides multiple references to the basics to help the student

Computational Neuroscience

Computational Neuroscience Book
Author : Anonim
Publisher : Academic Press
Release : 2014-02-18
ISBN : 0123979080
Language : En, Es, Fr & De

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Book Description :

Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. This volume brings together different aspects of, and approaches to, molecular and multi-scale modeling, with applications to a diverse range of neurological diseases. Mathematical and computational modeling offers a powerful approach for examining the interaction between molecular pathways and ionic channels in producing neuron electrical activity. It is well accepted that non-linear interactions among diverse ionic channels can produce unexpected neuron behavior and hinder a deep understanding of how ion channel mutations bring about abnormal behavior and disease. Interactions with the diverse signaling pathways activated by G protein coupled receptors or calcium influx adds an additional level of complexity. Modeling is an approach to integrate myriad data sources into a cohesive and quantitative model in order to evaluate hypotheses about neuron function. In particular, a validated model developed using in vitro data allows simulations of the response to in vivo like spatio-temporal patterns of synaptic input. Incorporating molecular signaling pathways into an electrical model, allows a greater range of models to be developed, ones that can predict the response to pharmaceuticals, many of which target neuromodulator pathways. Contributions from leading authorities Informs and updates on all the latest developments in the field

Seizure Prediction in Epilepsy

Seizure Prediction in Epilepsy Book
Author : Björn Schelter,Jens Timmer,Andreas Schulze-Bonhage
Publisher : Wiley-VCH
Release : 2008-10-13
ISBN : 9783527407569
Language : En, Es, Fr & De

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Book Description :

Comprising some 30 contributions, experts from around the world present and discuss recent advances related to seizure prediction in epilepsy. The book covers an extraordinarily broad spectrum, starting from modeling epilepsy in single cells or networks of a few cells to precisely-tailored seizure prediction techniques as applied to human data. This unique overview of our current level of knowledge and future perspectives provides theoreticians as well as practitioners, newcomers and experts with an up-to-date survey of developments in this important field of research.

Signal Processing for Neuroscientists

Signal Processing for Neuroscientists Book
Author : Wim van Drongelen
Publisher : Academic Press
Release : 2018-04-20
ISBN : 012810483X
Language : En, Es, Fr & De

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Book Description :

Signal Processing for Neuroscientists, Second Edition provides an introduction to signal processing and modeling for those with a modest understanding of algebra, trigonometry and calculus. With a robust modeling component, this book describes modeling from the fundamental level of differential equations all the way up to practical applications in neuronal modeling. It features nine new chapters and an exercise section developed by the author. Since the modeling of systems and signal analysis are closely related, integrated presentation of these topics using identical or similar mathematics presents a didactic advantage and a significant resource for neuroscientists with quantitative interest. Although each of the topics introduced could fill several volumes, this book provides a fundamental and uncluttered background for the non-specialist scientist or engineer to not only get applications started, but also evaluate more advanced literature on signal processing and modeling. Includes an introduction to biomedical signals, noise characteristics, recording techniques, and the more advanced topics of linear, nonlinear and multi-channel systems analysis Features new chapters on the fundamentals of modeling, application to neuronal modeling, Kalman filter, multi-taper power spectrum estimation, and practice exercises Contains the basics and background for more advanced topics in extensive notes and appendices Includes practical examples of algorithm development and implementation in MATLAB Features a companion website with MATLAB scripts, data files, figures and video lectures

Jasper s Basic Mechanisms of the Epilepsies

Jasper s Basic Mechanisms of the Epilepsies Book
Author : Herbert Henri Jasper
Publisher : OUP USA
Release : 2012-06-29
ISBN : 0199746540
Language : En, Es, Fr & De

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Book Description :

Prev. ed.: Jasper's basic mechanisms of the epilepsies / editors, Antonio V. Delgado-Escueta ... [et. al.]. 3rd. ed. c1999.

Neurotechnology Electronics and Informatics

Neurotechnology  Electronics  and Informatics Book
Author : Ana Rita Londral,Pedro Encarnação,José Luis Pons Rovira
Publisher : Springer
Release : 2015-07-15
ISBN : 3319159976
Language : En, Es, Fr & De

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Book Description :

The International Congress on Neurotechnology, Electronics, and Informatics (NEUROTECHNIX) took place in Algarve, Portugal in September of 2013. The congress provided a meeting point of academics and clinical and engineering professionals, promoting translational discussions on how research and technology can meet the needs of clinical practitioners and patients. NEUROTECHNIX emphasized research and application of neurotechnologies to various neurological disorders, including neuromuscular diseases, Parkinson's disease, developmental disorders, dementia, epilepsy, sleep disorders, Multiple Sclerosis, neuroinfections, brain tumors, stroke, traumatic brain injuries, Cerebral Palsy, spinal cord injury and vision and hearing disorders. Authors were invited to submit innovative research work that highlighted new advancements of neurotechnology. Papers describing case studies, advanced prototypes, systems, tools and techniques and general survey papers indicating future directions were encouraged. This book contains a limited selection of extended and revised versions of the best papers presented at the congress, by regular and keynote speakers.

Modeling Phase Transitions in the Brain

Modeling Phase Transitions in the Brain Book
Author : D. Alistair Steyn-Ross,Moira Steyn-Ross
Publisher : Springer Science & Business Media
Release : 2010-03-14
ISBN : 9781441907967
Language : En, Es, Fr & De

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Book Description :

Foreword by Walter J. Freeman. The induction of unconsciousness using anesthetic agents demonstrates that the cerebral cortex can operate in two very different behavioral modes: alert and responsive vs. unaware and quiescent. But the states of wakefulness and sleep are not single-neuron properties---they emerge as bulk properties of cooperating populations of neurons, with the switchover between states being similar to the physical change of phase observed when water freezes or ice melts. Some brain-state transitions, such as sleep cycling, anesthetic induction, epileptic seizure, are obvious and detected readily with a few EEG electrodes; others, such as the emergence of gamma rhythms during cognition, or the ultra-slow BOLD rhythms of relaxed free-association, are much more subtle. The unifying theme of this book is the notion that all of these bulk changes in brain behavior can be treated as phase transitions between distinct brain states. Modeling Phase Transitions in the Brain contains chapter contributions from leading researchers who apply state-space methods, network models, and biophysically-motivated continuum approaches to investigate a range of neuroscientifically relevant problems that include analysis of nonstationary EEG time-series; network topologies that limit epileptic spreading; saddle--node bifurcations for anesthesia, sleep-cycling, and the wake--sleep switch; prediction of dynamical and noise-induced spatiotemporal instabilities underlying BOLD, alpha-, and gamma-band Hopf oscillations, gap-junction-moderated Turing structures, and Hopf-Turing interactions leading to cortical waves.