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Computational Modeling In Bioengineering And Bioinformatics

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Computational Bioengineering and Bioinformatics

Computational Bioengineering and Bioinformatics Book
Author : Nenad Filipovic
Publisher : Springer Nature
Release : 2020-03-11
ISBN : 3030436586
Language : En, Es, Fr & De

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Book Description :

This book explores the latest and most relevant topics in the field of computational bioengineering and bioinformatics, with a particular focus on patient-specific, disease-progression modeling. It covers computational methods for cardiovascular disease prediction, with an emphasis on biomechanics, biomedical decision support systems, data mining, personalized diagnostics, bio-signal processing, protein structure prediction, biomedical image processing, analysis and visualization, and high-performance computing. It also discusses state-of-the-art tools for disease characterization, and recent advances in areas such as biomechanics, cardiovascular engineering, patient-specific modeling, population-based modeling, multiscale modeling, image processing, data mining, biomedical decision-support systems, signal processing, biomaterials and dental biomechanics, tissue and cell engineering, computational chemistry and high-performance computing. As such, it is a valuable resource for researchers, medical and bioengineering students, and medical device and software experts

Computational Modeling in Bioengineering and Bioinformatics

Computational Modeling in Bioengineering and Bioinformatics Book
Author : Nenad Filipovic
Publisher : Academic Press
Release : 2019-10-09
ISBN : 0128195843
Language : En, Es, Fr & De

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Book Description :

Computational Modeling in Bioengineering and Bioinformatics promotes complementary disciplines that hold great promise for the advancement of research and development in complex medical and biological systems, and in the environment, public health, drug design, and so on. It provides a common platform by bridging these two very important and complementary disciplines into an interactive and attractive forum. Chapters cover biomechanics and bioimaging, biomedical decision support system, data mining, personalized diagnoses, bio-signal processing, protein structure prediction, tissue and cell engineering, biomedical image processing, analysis and visualization, high performance computing and sports bioengineering. The book's chapters are the result of many international projects in the area of bioengineering and bioinformatics done at the Research and Development Center for Bioengineering BioIRC and by the Faculty of Engineering at the University of Kragujevac, Serbia. Presents recent advances at the crossroads of biomedical engineering and bioinformatics, one of the hottest areas in biomedical and clinical research Discusses a wide range of leading-edge research topics, including biomechanics and bioimaging, biomedical decision support systems, data mining, personalized diagnoses, bio-signal processing, protein structure prediction, tissue and cell engineering, amongst others Includes coverage of biomechanical, bioengineering and computational methods of treatment and diagnosis

Computational Modeling and Simulation Examples in Bioengineering

Computational Modeling and Simulation Examples in Bioengineering Book
Author : Nenad Filipovic
Publisher : John Wiley & Sons
Release : 2021-11-30
ISBN : 1119563917
Language : En, Es, Fr & De

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Book Description :

A systematic overview of the quickly developing field of bioengineering—with state-of-the-art modeling software! Computational Modeling and Simulation Examples in Bioengineering provides a comprehensive introduction to the emerging field of bioengineering. It provides the theoretical background necessary to simulating pathological conditions in the bones, muscles, cardiovascular tissue, and cancers, as well as lung and vertigo disease. The methodological approaches used for simulations include the finite element, dissipative particle dynamics, and lattice Boltzman. The text includes access to a state-of-the-art software package for simulating the theoretical problems. In this way, the book enhances the reader's learning capabilities in the field of biomedical engineering. The aim of this book is to provide concrete examples of applied modeling in biomedical engineering. Examples in a wide range of areas equip the reader with a foundation of knowledge regarding which problems can be modeled with which numerical methods. With more practical examples and more online software support than any competing text, this book organizes the field of computational bioengineering into an accessible and thorough introduction. Computational Modeling and Simulation Examples in Bioengineering: Includes a state-of-the-art software package enabling readers to engage in hands-on modeling of the examples in the book Provides a background on continuum and discrete modeling, along with equations and derivations for three key numerical methods Considers examples in the modeling of bones, skeletal muscles, cartilage, tissue engineering, blood flow, plaque, and more Explores stent deployment modeling as well as stent design and optimization techniques Generates different examples of fracture fixation with respect to the advantages in medical practice applications Computational Modeling and Simulation Examples in Bioengineering is an excellent textbook for students of bioengineering, as well as a support for basic and clinical research. Medical doctors and other clinical professionals will also benefit from this resource and guide to the latest modeling techniques.

Bioinformatics and Computational Biology

Bioinformatics and Computational Biology Book
Author : Basant K. Tiwary
Publisher : Springer Nature
Release : 2021-11-23
ISBN : 9811642419
Language : En, Es, Fr & De

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Book Description :

This textbook introduces fundamental concepts of bioinformatics and computational biology to the students and researchers in biology, medicine, veterinary science, agriculture, and bioengineering . The respective chapters provide detailed information on biological databases, sequence alignment, molecular evolution, next-generation sequencing, systems biology, and statistical computing using R. The book also presents a case-based discussion on clinical, veterinary, agricultural bioinformatics, and computational bioengineering for application-based learning in the respective fields. Further, it offers readers guidance on reconstructing and analysing biological networks and highlights computational methods used in systems medicine and genome-wide association mapping of diseases. Given its scope, this textbook offers an essential introductory book on bioinformatics and computational biology for undergraduate and graduate students in the life sciences, botany, zoology, physiology, biotechnology, bioinformatics, and genomic science as well as systems biology, bioengineering and the agricultural, and veterinary sciences.

Uncertainty in Biology

Uncertainty in Biology Book
Author : Liesbet Geris,David Gomez-Cabrero
Publisher : Springer
Release : 2015-10-26
ISBN : 3319212966
Language : En, Es, Fr & De

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Book Description :

Computational modeling allows to reduce, refine and replace animal experimentation as well as to translate findings obtained in these experiments to the human background. However these biomedical problems are inherently complex with a myriad of influencing factors, which strongly complicates the model building and validation process. This book wants to address four main issues related to the building and validation of computational models of biomedical processes: 1. Modeling establishment under uncertainty 2. Model selection and parameter fitting 3. Sensitivity analysis and model adaptation 4. Model predictions under uncertainty In each of the abovementioned areas, the book discusses a number of key-techniques by means of a general theoretical description followed by one or more practical examples. This book is intended for graduate students and researchers active in the field of computational modeling of biomedical processes who seek to acquaint themselves with the different ways in which to study the parameter space of their model as well as its overall behavior.

Computational Models for Biomedical Reasoning and Problem Solving

Computational Models for Biomedical Reasoning and Problem Solving Book
Author : Chen, Chung-Hao,Cheung, Sen-Ching Samson
Publisher : IGI Global
Release : 2019-04-12
ISBN : 1522574689
Language : En, Es, Fr & De

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Book Description :

The results of computational model simulations allow researchers and clinicians to make predictions about what will happen in the biological systems that are being studied in response to changing conditions for a disease or disorder. With a well-developed computational model, researchers and clinicians can better understand the cause of a disease or a disorder and predict treatment results. Computational Models for Biomedical Reasoning and Problem Solving is a critical scholarly publication that provides insightful strategies to developing computational models that allow for the better understanding and treatment of various diseases and disorders. Featuring topics such as biomedicine, neuroscience, and artificial intelligence, this book is ideal for practitioners, clinicians, researchers, psychologists, and engineers.

Advances in Computational and Bio Engineering

Advances in Computational and Bio Engineering Book
Author : S. Jyothi,D. M. Mamatha,Suresh Chandra Satapathy,K. Srujan Raju,Margarita N. Favorskaya
Publisher : Springer Nature
Release : 2020-07-19
ISBN : 3030469395
Language : En, Es, Fr & De

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Book Description :

This book gathers state-of-the-art research in computational engineering and bioengineering to facilitate knowledge exchange between various scientific communities. Computational engineering (CE) is a relatively new discipline that addresses the development and application of computational models and simulations often coupled with high-performance computing to solve complex physical problems arising in engineering analysis and design in the context of natural phenomena. Bioengineering (BE) is an important aspect of computational biology, which aims to develop and use efficient algorithms, data structures, and visualization and communication tools to model biological systems. Today, engineering approaches are essential for biologists, enabling them to analyse complex physiological processes, as well as for the pharmaceutical industry to support drug discovery and development programmes.

Cardiovascular and Respiratory Bioengineering

Cardiovascular and Respiratory Bioengineering Book
Author : Nenad Filipovic
Publisher : Academic Press
Release : 2022-05-27
ISBN : 0128242299
Language : En, Es, Fr & De

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Book Description :

Cardiovascular and Respiratory Bioengineering focuses on computational tools and modeling techniques in cardiovascular and respiratory systems that help develop bioengineered solutions. The book demonstrates how these technologies can be utilized in order to tackle diseases and medical issues. It provides practical guidance on how a bioengineering or medical problem can be modeled, along with which computational models can be used. Topics include computer modeling of Purkinje fibers with different electrical potential applied, modeling of cardiomyopathies caused by sarcomeric gene mutations, altered sarcomere function, perturbations in intracellular ion homeostasis, impaired myocardial energetics at reduced costs, and more. The book also discusses blood flow through deformable blood vessels in human aorta, abdominal aortic aneurysm, carotid artery, coronary artery and plaque formation, along with content on stent deployment modeling and stent design and optimization techniques. Features practical applications of cardiovascular and respiratory technology to counteract diseases Includes detailed steps for the modeling of cardiovascular and respiratory systems Explores a range of different modeling methods, including computational modeling, predictive modeling and multi-scale modeling Covers biological processes and biomechanics relevant to cardiovascular and respiratory bioengineering

Computational Biomechanics

Computational Biomechanics Book
Author : Kozaburo Hayashi,Hiromasa Ishikawa
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 4431669515
Language : En, Es, Fr & De

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Book Description :

The combination of readily available computing power and progress in numerical techniques has made nonlinear systems - the kind that only a few years ago were ignored as too complex - open to analysis for the first time. Now realistic models of living systems incorporating the nonlinear variation and anisotropic nature of physical properties can be solved numerically on modern computers to give realistically usable results. This has opened up new and exciting possibilities for the fusing of ideas from physiology and engineering in the burgeoning new field that is biomechanics. Computational Biomechanics presents pioneering work focusing on the areas of orthopedic and circulatory mechanics, using experimental results to confirm or improve the relevant mathematical models and parameters. Together with two companion volumes, Biomechanics: Functional Adaptation and Remodeling and the Data Book on Mechanical Properties of Living Cells, Tissues, and Organs, this monograph will prove invaluable to those working in fields ranging from medical science and clinical medicine to biomedical engineering and applied mechanics.

Mathematical Models in Biology

Mathematical Models in Biology Book
Author : Valeria Zazzu,Maria Brigida Ferraro,Mario R. Guarracino
Publisher : Springer
Release : 2015-11-26
ISBN : 3319234978
Language : En, Es, Fr & De

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Book Description :

This book presents an exciting collection of contributions based on the workshop “Bringing Maths to Life” held October 27-29, 2014 in Naples, Italy. The state-of-the art research in biology and the statistical and analytical challenges facing huge masses of data collection are treated in this Work. Specific topics explored in depth surround the sessions and special invited sessions of the workshop and include genetic variability via differential expression, molecular dynamics and modeling, complex biological systems viewed from quantitative models, and microscopy images processing, to name several. In depth discussions of the mathematical analysis required to extract insights from complex bodies of biological datasets, to aid development in the field novel algorithms, methods and software tools for genetic variability, molecular dynamics, and complex biological systems are presented in this book. Researchers and graduate students in biology, life science, and mathematics/statistics will find the content useful as it addresses existing challenges in identifying the gaps between mathematical modeling and biological research. The shared solutions will aid and promote further collaboration between life sciences and mathematics.

Catalyzing Inquiry at the Interface of Computing and Biology

Catalyzing Inquiry at the Interface of Computing and Biology Book
Author : National Research Council,Division on Engineering and Physical Sciences,Computer Science and Telecommunications Board,Committee on Frontiers at the Interface of Computing and Biology
Publisher : National Academies Press
Release : 2006-01-01
ISBN : 030909612X
Language : En, Es, Fr & De

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Book Description :

Advances in computer science and technology and in biology over the last several years have opened up the possibility for computing to help answer fundamental questions in biology and for biology to help with new approaches to computing. Making the most of the research opportunities at the interface of computing and biology requires the active participation of people from both fields. While past attempts have been made in this direction, circumstances today appear to be much more favorable for progress. To help take advantage of these opportunities, this study was requested of the NRC by the National Science Foundation, the Department of Defense, the National Institutes of Health, and the Department of Energy. The report provides the basis for establishing cross-disciplinary collaboration between biology and computing including an analysis of potential impediments and strategies for overcoming them. The report also presents a wealth of examples that should encourage students in the biological sciences to look for ways to enable them to be more effective users of computing in their studies.

Issues in Bioengineering and Bioinformatics 2011 Edition

Issues in Bioengineering and Bioinformatics  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464964173
Language : En, Es, Fr & De

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Book Description :

Issues in Bioengineering and Bioinformatics: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Bioengineering and Bioinformatics. The editors have built Issues in Bioengineering and Bioinformatics: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bioengineering and Bioinformatics in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Bioengineering and Bioinformatics: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Computational Modeling of Gene Regulatory Networks

Computational Modeling of Gene Regulatory Networks Book
Author : Hamid Bolouri
Publisher : Imperial College Press
Release : 2008
ISBN : 1848162200
Language : En, Es, Fr & De

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Book Description :

This book serves as an introduction to the myriad computational approaches to gene regulatory modeling and analysis, and is written specifically with experimental biologists in mind. Mathematical jargon is avoided and explanations are given in intuitive terms. In cases where equations are unavoidable, they are derived from first principles or, at the very least, an intuitive description is provided. Extensive examples and a large number of model descriptions are provided for use in both classroom exercises as well as self-guided exploration and learning. As such, the book is ideal for self-learning and also as the basis of a semester-long course for undergraduate and graduate students in molecular biology, bioengineering, genome sciences, or systems biology.

Computational Systems Bioinformatics Methods And Biomedical Applications

Computational Systems Bioinformatics   Methods And Biomedical Applications Book
Author : Wong Stephen Tin Chi,Zhou Xiaobo
Publisher : World Scientific Publishing Company
Release : 2008-01-02
ISBN : 9813106999
Language : En, Es, Fr & De

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Book Description :

Computational systems biology is a new and rapidly developing field of research, concerned with understanding the structure and processes of biological systems at the molecular, cellular, tissue, and organ levels through computational modeling as well as novel information theoretic data and image analysis methods. By focusing on either information processing of biological data or on modeling physical and chemical processes of biosystems, and in combination with the recent breakthrough in deciphering the human genome, computational systems biology is guaranteed to play a central role in disease prediction and preventive medicine, gene technology and pharmaceuticals, and other biotechnology fields.This book begins by introducing the basic mathematical, statistical, and data mining principles of computational systems biology, and then presents bioinformatics technology in microarray and sequence analysis step-by-step. Offering an insightful look into the effectiveness of the systems approach in computational biology, it focuses on recurrent themes in bioinformatics, biomedical applications, and future directions for research.

Recent Advances in Cancer Diagnostics and Therapy

Recent Advances in Cancer Diagnostics and Therapy Book
Author : Anjana Pandey,Saumya Srivastava
Publisher : CRC Press
Release : 2022-01-19
ISBN : 1000528138
Language : En, Es, Fr & De

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Book Description :

The book provides information about different types and stages of cancers and their subtypes with their respective molecular mechanisms, etiology, histopathology and cellular origins of cancer. The book also provides detailed information about cancer incidence, mortality, different type of technologies both bio and nano employed in cancer diagnosis and screening and their applications in cancer therapies. The book will serve the purpose to impart knowledge to its readers about molecular mechanisms of cancer, diagnosis and therapies along with different computational techniques used on a single platform. The chapters include a broad and integrated perspective on cancer related topics. The book covers both conventional and emerging techniques employed in cancer screening and diagnosis including imaging, biomarker and electrochemical nanosensor based approaches with detailed information on sensor development. Similarly, the book also covers the mechanisms of different conventional and emerging herbal & nano therapies used in cancer treatment. The authors then discuss about applications of different computational and mathematical tools such as machine learning methods that can be employed in cancer diagnosis and therapy at the level of personalized medicine. The target readers for the book include university students, course lectures, researchers and industrialists working in the fields of cancer biology, medicine, and pharmacology. Features: An integrated approach to provide information about all aspects of cancer biology, diagnosis and therapy. Covers both conventional and emerging tools/ techniques applicable in cancer screening and diagnosis. Covers the mechanisms of conventional and emerging anticancer drugs and therapies. Provides insights about personalized medicine based approach in cancer diagnosis and therapy.

Computational Science ICCS 2018

Computational Science     ICCS 2018 Book
Author : Yong Shi,Haohuan Fu,Yingjie Tian,Valeria V. Krzhizhanovskaya,Michael Harold Lees,Jack Dongarra,Peter M. A. Sloot
Publisher : Springer
Release : 2018-06-11
ISBN : 3319937014
Language : En, Es, Fr & De

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Book Description :

The three-volume set LNCS 10860, 10861 and 10862 constitutes the proceedings of the 18th International Conference on Computational Science, ICCS 2018, held in Wuxi, China, in June 2018. The total of 155 full and 66 short papers presented in this book set was carefully reviewed and selected from 404 submissions. The papers were organized in topical sections named: Part I: ICCS Main Track Part II: Track of Advances in High-Performance Computational Earth Sciences: Applications and Frameworks; Track of Agent-Based Simulations, Adaptive Algorithms and Solvers; Track of Applications of Matrix Methods in Artificial Intelligence and Machine Learning; Track of Architecture, Languages, Compilation and Hardware Support for Emerging ManYcore Systems; Track of Biomedical and Bioinformatics Challenges for Computer Science; Track of Computational Finance and Business Intelligence; Track of Computational Optimization, Modelling and Simulation; Track of Data, Modeling, and Computation in IoT and Smart Systems; Track of Data-Driven Computational Sciences; Track of Mathematical-Methods-and-Algorithms for Extreme Scale; Track of Multiscale Modelling and Simulation Part III: Track of Simulations of Flow and Transport: Modeling, Algorithms and Computation; Track of Solving Problems with Uncertainties; Track of Teaching Computational Science; Poster Papers

Integrating Meta heuristics and Machine Learning for Real world Optimization Problems

Integrating Meta heuristics and Machine Learning for Real world Optimization Problems Book
Author : Essam H. Houssein,Mohamed Abd Elaziz,Diego Oliva,Laith Abualigah
Publisher : Springer Nature
Release : 2022
ISBN : 3030990796
Language : En, Es, Fr & De

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Book Description :

This book collects different methodologies that permit metaheuristics and machine learning to solve real-world problems. This book has exciting chapters that employ evolutionary and swarm optimization tools combined with machine learning techniques. The fields of applications are from distribution systems until medical diagnosis, and they are also included different surveys and literature reviews that will enrich the reader. Besides, cutting-edge methods such as neuroevolutionary and IoT implementations are presented in some chapters. In this sense, the book provides theory and practical content with novel machine learning and metaheuristic algorithms. The chapters were compiled using a scientific perspective. Accordingly, the book is primarily intended for undergraduate and postgraduate students of Science, Engineering, and Computational Mathematics and can be used in courses on Artificial Intelligence, Advanced Machine Learning, among others. Likewise, the material can be helpful for research from the evolutionary computation, artificial intelligence communities.

Computational Models in Biomedical Engineering

Computational Models in Biomedical Engineering Book
Author : Milos Kojic,Miljan Milosevic,Arturas Ziemys
Publisher : Academic Press
Release : 2022-09-11
ISBN : 0323906699
Language : En, Es, Fr & De

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Book Description :

Computational Models in Biomedical Engineering: Finite Element Models Based on Smeared Physical Fields: Theory, Solutions, and Software discusses novel computational methodologies developed by the authors that address a variety of topics in biomedicine, with concepts that rely on the so-called smeared physical field built into the finite element method. A new and straightforward methodology is represented by their Kojic Transport Model (KTM), where a composite smeared finite element (CSFE) as a FE formulation contains different fields (e.g., drug concentration, electrical potential) in a composite medium, such as tissue, which includes the capillary and lymphatic system, different cell groups and organelles. The continuum domains participate in the overall model according to their volumetric fractions. The governing laws and material parameters are assigned to each of the domains. Furthermore, the continuum fields are coupled at each FE node by connectivity elements which take into account biological barriers such as vessel walls and cells. Provides a methodology based on the smeared concept within the finite element method which is simple, straightforward and easy to use Enables the modeling of complex physical field problems and the mechanics of biological systems Includes features that are illustrated in chapters devoted to applications surrounding tissue, heart and lung Includes a methodology that can serve as a basis for further enhancements by including additional phenomena which can be described by relevant relationships, derived theoretically or experimentally observed in laboratories and clinics

Introduction to Computational Bioengineering

Introduction to Computational Bioengineering Book
Author : Guigen Zhang
Publisher : CRC Press
Release : 2016-01-15
ISBN : 9781466572287
Language : En, Es, Fr & De

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Book Description :

This textbook is designed for an introductory course at undergraduate and graduate levels for bioengineering students. It provides a systematic way of examining bioengineering problems in a multidisciplinary computational approach. The book introduces basic concepts of multidiscipline-based computational modeling methods, provides detailed step-by-step techniques to build a model with consideration of underlying multiphysics, and discusses many important aspects of a modeling approach including results interpretation, validation, and assessment.

Computer Modeling in Bioengineering

Computer Modeling in Bioengineering Book
Author : Miloš Kojić,Nenad Filipović,Boban Stojanović,Nikola Kojić
Publisher : John Wiley & Sons
Release : 2008-09-15
ISBN : 0470751754
Language : En, Es, Fr & De

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Book Description :

Bioengineering is a broad-based engineering discipline that appliesengineering principles and design to challenges in human health andmedicine, dealing with bio-molecular and molecular processes,product design, sustainability and analysis of biological systems.Applications that benefit from bioengineering include medicaldevices, diagnostic equipment and biocompatible materials, amongstothers. Computer Modeling in Bioengineering offers acomprehensive reference for a large number of bioengineeringtopics, presenting important computer modeling problems andsolutions for research and medical practice. Starting with basictheory and fundamentals, the book progresses to more advancedmethods and applications, allowing the reader to become familiarwith different topics to the desired extent. It includes unique andoriginal topics alongside classical computational modeling methods,and each application is structured to explain the physiologicalbackground, phenomena that are to be modeled, the computationalmethods used in the model, and solutions of typical cases. Theaccompanying software contains over 80 examples, enabling thereader to study a topic using the theory and examples, then run thesoftware to solve the same, or similar examples, varying the modelparameters within a given range in order to investigate the problemat greater depth. Tutorials also guide the user in furtherexploring the modeled problem; these features promote easierlearning and will help lecturers with presentations. Computer Modeling in Bioengineering includescomputational methods for modelling bones, tissues, muscles,cardiovascular components, cartilage, cells and cancernanotechnology as well as many other applications. It bridges thegap between engineering, biology and medicine, and will appeal notonly to bioengineering students, lecturers and researchers, butalso medical students and clinical researchers.