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Computational Epigenetics And Diseases

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Computational Epigenetics and Diseases

Computational Epigenetics and Diseases Book
Author : Anonim
Publisher : Academic Press
Release : 2019-02-06
ISBN : 0128145145
Language : En, Es, Fr & De

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Book Description :

Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases

Exam Prep for Computational Epigenetics and Diseases

Exam Prep for  Computational Epigenetics and Diseases Book
Author : Anonim
Publisher : Unknown
Release : 2021-05-14
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Exam Prep for Computational Epigenetics and Diseases book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Computational Epigenetics in Human Diseases Cell Differentiation and Cell Reprogramming Volume I

Computational Epigenetics in Human Diseases  Cell Differentiation  and Cell Reprogramming  Volume I Book
Author : Jianzhong Su,Meng Zhou,Yongchun Zuo,Xiaotian Zhang
Publisher : Frontiers Media SA
Release : 2021-02-24
ISBN : 2889665046
Language : En, Es, Fr & De

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Book Description :

Download Computational Epigenetics in Human Diseases Cell Differentiation and Cell Reprogramming Volume I book written by Jianzhong Su,Meng Zhou,Yongchun Zuo,Xiaotian Zhang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Computational Psychiatry

Computational Psychiatry Book
Author : Rodrick Wallace
Publisher : Springer
Release : 2017-04-20
ISBN : 3319539108
Language : En, Es, Fr & De

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Book Description :

This book explores mental disorders from a uniquely evolutionary perspective. Although there have been many attempts to mathematically model neural processes and, to some extent, their dysfunction, there is very little literature that models mental function within a sociocultural, socioeconomic, and environmental context. Addressing this gap in the extant literature, this book explores essential aspects of mental disorders, recognizing the ubiquitous role played by the exaptation of crosstalk between cognitive modules at many different scales and levels of organization, the missing heritability of complex diseases, and cultural epigenetics. Further, it introduces readers to valuable control theory tools that permit the exploration of the environmental induction of neurodevelopmental disorders, as well as the study of the synergism between culture, psychopathology and sleep disorders, offering a distinctively unique resource.

Epigenetics Methods

Epigenetics Methods Book
Author : Trygve Tollefsbol
Publisher : Academic Press
Release : 2020-07-08
ISBN : 0128194154
Language : En, Es, Fr & De

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Book Description :

In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used to study various epigenetic mechanisms, as employed in basic and translational research. Leading the reader from fundamental to more advanced methods, the book begins with thorough instruction in DNA methylation techniques and gene or locus-specific methylation analyses, followed by histone modification methods, chromatin evaluation, enzyme analyses of histone methylation, and studies of non-coding RNAs as epigenetic modulators. Recently developed techniques and technologies discussed include single-cell epigenomics, epigenetic editing, computational epigenetics, systems biology epigenetic methods, and forensic epigenetic approaches. Epigenetics methods currently in-development, and their implication for future research, are also considered in-depth. In addition, as with the wider life sciences, reproducibility across experiments, labs, and subdisciplines is a growing issue for epigenetics researchers. This volume provides consensus-driven methods instruction and overviews. Tollefsbol and contributing authors survey the range of existing methods; identify best practices, common themes, and challenges; and bring unity of approach to a diverse and ever-evolving field. Includes contributions by leading international investigators involved in epigenetic research and clinical and therapeutic application Integrates technology and translation with fundamental chapters on epigenetics methods, as well as chapters on more novel and advanced epigenetics methods Written at verbal and technical levels that can be understood by scientists and students alike Includes chapters on state-of-the-art techniques such as single-cell epigenomics, use of CRISPR/Cas9 for epigenetic editing, and epigenetics methods applied to forensics

Transcriptomics and Gene Regulation

Transcriptomics and Gene Regulation Book
Author : Jiaqian Wu
Publisher : Springer
Release : 2015-11-17
ISBN : 9401774501
Language : En, Es, Fr & De

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Book Description :

This volume focuses on modern computational and statistical tools for translational gene expression and regulation research to improve prognosis, diagnostics, prediction of severity, and therapies for human diseases. It introduces some of state of the art technologies as well as computational and statistical tools for translational bioinformatics in the areas of gene transcription and regulation, including the tools for next generation sequencing analyses, alternative spicing, the modeling of signaling pathways, network analyses in predicting disease genes, as well as protein and gene expression data integration in complex human diseases etc. The book is particularly useful for researchers and students in the field of molecular biology, clinical biology and bioinformatics, as well as physicians etc. Dr. Jiaqian Wu is assistant professor in the Vivian L. Smith Department of Neurosurgery and Center for Stem Cell and Regenerative Medicine, University of Texas Health Science Centre, Houston, TX, USA.‚Äč

Genetic Engineering Biotechnology News

Genetic Engineering   Biotechnology News Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Genetic Engineering Biotechnology News book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Computational Methods to Discern the Genetic Basis of Complex Disease

Computational Methods to Discern the Genetic Basis of Complex Disease Book
Author : Megan D Roytman
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Genome-wide association studies (GWAS) have identified thousands of regions in the genome containing risk variants for complex traits. Due to the correlation structure between ge- netic variants, there is a need for computational methods that can tease apart causal from non-causal variants in these implicated regions. This dissertation presents three statistical methods that aim to improve our detection of causal variants at risk regions and ultimately better our understanding of the genetic basis of complex disease. The first method aims to fine-map genetic regions impacting multiple correlated traits at once, employing the Multivariate Normal (MVN) distribution to jointly model association statistics at a risk region. The second method performs hierarchical fine-mapping on risk regions that show evidence for a SNP impacting gene expression through an epigenetic feature, such as histone modifi- cations. It uses both the MVN as well as the Matrix-variate Normal distribution to jointly model effects from SNP to epigenetic mark to gene expression. The third method builds on existing summary statistics imputation methods by integrating functional annotation data to improve prediction of associations at untyped SNPs.

Journal of Computational and Theoretical Nanoscience

Journal of Computational and Theoretical Nanoscience Book
Author : Anonim
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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The Staphylococci in Human Disease

The Staphylococci in Human Disease Book
Author : Kent B. Crossley,Gordon Archer
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This is the first new book on all Staphylococcal infections in many years. It is particularly timely, considering the growing problem of antibiotic resistant staph infections. It covers all Staph infections including hospital infections, toxic shock syndrome, infections in prosthetic devices, immunocompromised patients, and more.

Comprehensive Medicinal Chemistry II Vol 8

Comprehensive Medicinal Chemistry II  Vol 8 Book
Author : John B Taylor,David J Triggle
Publisher : Elsevier Science Limited
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Presents a different view of medicinal chemistry through personal accounts by eminent scientists describing their lifetime experiences in the field. Also illustrates 14 case studies of successful drug discovery and development. * valuable content available May 2009 as an individual volume * separate volumes will appeal to a wider chemistry, biochemistry and medicinal audience * priced for individual researcher as well as library purchase

Systems Biology in Toxicology and Environmental Health

Systems Biology in Toxicology and Environmental Health Book
Author : Rebecca Fry
Publisher : Academic Press
Release : 2015-06-11
ISBN : 0128015683
Language : En, Es, Fr & De

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Book Description :

Systems Biology in Toxicology and Environmental Health uses a systems biological perspective to detail the most recent findings that link environmental exposures to human disease, providing an overview of molecular pathways that are essential for cellular survival after exposure to environmental toxicants, recent findings on gene-environment interactions influencing environmental agent-induced diseases, and the development of computational methods to predict susceptibility to environmental agents. Introductory chapters on molecular and cellular biology, toxicology and computational biology are included as well as an assessment of systems-based tools used to evaluate environmental health risks. Further topics include research on environmental toxicants relevant to human health and disease, various high-throughput technologies and computational methods, along with descriptions of the biological pathways associated with disease and the developmental origins of disease as they relate to environmental contaminants. Systems Biology in Toxicology and Environmental Health is an essential reference for undergraduate students, graduate students, and researchers looking for an introduction in the use of systems biology approaches to assess environmental exposures and their impacts on human health. Provides the first reference of its kind, demonstrating the application of systems biology in environmental health and toxicology Includes introductions to the diverse fields of molecular and cellular biology, toxicology, and computational biology Presents a foundation that helps users understand the connections between the environment and health effects, and the biological mechanisms that link them

Bioinformatics in Aquaculture

Bioinformatics in Aquaculture Book
Author : Zhanjiang (John) Liu
Publisher : John Wiley & Sons
Release : 2017-04-17
ISBN : 1118782356
Language : En, Es, Fr & De

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Book Description :

Bioinformatics derives knowledge from computer analysis of biological data. In particular, genomic and transcriptomic datasets are processed, analysed and, whenever possible, associated with experimental results from various sources, to draw structural, organizational, and functional information relevant to biology. Research in bioinformatics includes method development for storage, retrieval, and analysis of the data. Bioinformatics in Aquaculture provides the most up to date reviews of next generation sequencing technologies, their applications in aquaculture, and principles and methodologies for the analysis of genomic and transcriptomic large datasets using bioinformatic methods, algorithm, and databases. The book is unique in providing guidance for the best software packages suitable for various analysis, providing detailed examples of using bioinformatic software and command lines in the context of real world experiments. This book is a vital tool for all those working in genomics, molecular biology, biochemistry and genetics related to aquaculture, and computational and biological sciences.

Epigenetics of the Immune System

Epigenetics of the Immune System Book
Author : Dieter Kabelitz,Jaydeep Bhat
Publisher : Academic Press
Release : 2020-06-04
ISBN : 0128179651
Language : En, Es, Fr & De

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Book Description :

Epigenetics of the Immune System focuses on different aspects of epigenetics and immunology, providing readers with the fundamental mechanisms relating to epigenetics and the immune system. This book provides in-depth information on immune cells as a toolbox in deciphering systematically regulated mechanisms using "omics" and computational biology approaches. In addition, the book presents the translational importance of epigenetics and the immune system in our understanding of pathophysiology in diseases and its therapeutic applications. Provides an overview of most important immune mechanisms, the current status of epigenetics, and how both of them are brought together Presents key principles of immune mechanisms in epigenetics, presenting current findings and key principles Features in-depth chapter contributions from a wide range of international researchers and specialists in immunology, translational medicine and epigenetics Merges two very large areas, covering the unique interrelatedness of epigenetics and immunology

Bioinformatics for Diagnosis Prognosis and Treatment of Complex Diseases

Bioinformatics for Diagnosis  Prognosis and Treatment of Complex Diseases Book
Author : Bairong Shen
Publisher : Springer Science & Business Media
Release : 2013-11-25
ISBN : 9400779755
Language : En, Es, Fr & De

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Book Description :

The book introduces the bioinformatics tools, databases and strategies for the translational research, focuses on the biomarker discovery based on integrative data analysis and systems biological network reconstruction. With the coming of personal genomics era, the biomedical data will be accumulated fast and then it will become reality for the personalized and accurate diagnosis, prognosis and treatment of complex diseases. The book covers both state of the art of bioinformatics methodologies and the examples for the identification of simple or network biomarkers. In addition, bioinformatics software tools and scripts are provided to the practical application in the study of complex diseases. The present state, the future challenges and perspectives were discussed. The book is written for biologists, biomedical informatics scientists and clinicians, etc. Dr. Bairong Shen is Professor and Director of Center for Systems Biology, Soochow University; he is also Director of Taicang Center for Translational Bioinformatics.

Genomic Imprinting

Genomic Imprinting Book
Author : Hiroyuki Sasaki,Fumitoshi Ishino
Publisher : S Karger Ag
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Genomic imprinting, a parent-of-origin-specific epigenetic modification of the genome, is observed in placental mammals and some plants (angiosperms). Since its discovery in the early 1980s, this intriguing phenomenon has been intensively investigated and has spawned an exciting new research area. Imprinting is relevant to a variety of biological events such as embryogenesis, growth and behavior, and its disruption can lead to congenital malformation syndromes and cancers. Furthermore, imprinting has been serving as an excellent model system to study epigenetic mechanisms of gene regulation and helping us to understand how gene clusters and genome domains are regulated. This special issue provides an overview of the current knowledge of genomic imprinting. Including both excellent reviews and original research articles by outstanding researchers in the field, many of which were participants of the genomic imprinting workshops in Montpellier (September 2004) and Oxford (April 2005), it represents the forefront of imprinting research.

RNA Based Regulation in Human Health and Disease

RNA Based Regulation in Human Health and Disease Book
Author : Anonim
Publisher : Academic Press
Release : 2020-08-15
ISBN : 0128171944
Language : En, Es, Fr & De

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Book Description :

RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field

New Scientist

New Scientist Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download New Scientist book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Science

Science Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Science book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.