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Computational Epigenetics and Diseases

Computational Epigenetics and Diseases Book
Author : Anonim
Publisher : Academic Press
Release : 2019-02-06
ISBN : 0128145145
Language : En, Es, Fr & De

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Book Description :

Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases

Computational Epigenetics in Human Diseases Cell Differentiation and Cell Reprogramming Volume I

Computational Epigenetics in Human Diseases  Cell Differentiation  and Cell Reprogramming  Volume I Book
Author : Jianzhong Su,Meng Zhou,Yongchun Zuo,Xiaotian Zhang
Publisher : Frontiers Media SA
Release : 2021-02-24
ISBN : 2889665046
Language : En, Es, Fr & De

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Book Description :

Download Computational Epigenetics in Human Diseases Cell Differentiation and Cell Reprogramming Volume I book written by Jianzhong Su,Meng Zhou,Yongchun Zuo,Xiaotian Zhang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Computational Epigenomics and Disease

Computational Epigenomics and Disease Book
Author : Misook Ha
Publisher : Academic Press
Release : 2017-01-01
ISBN : 9780128041048
Language : En, Es, Fr & De

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Book Description :

Computational Epigenomics and Diseases: Epigenomic Data Analytics for Human Health Application explains the current computational approaches inferring epigenetic mechanisms from epigenetic data. Epigenetic research leads to a considerable amount of data that can be more efficiently organized and analyzed using computer-based systems. All applicable computational approaches are explained in detail within this volume. Computational Epigenetics discusses topics such as statistical analysis and management of big epigenetics datasets; relationships among epigenetic factors and diseases; computational inference of spatial organization of genome; differential regulations and inference of variations of chromatin modifications; and systems biology approaches for identifying chromatin regulators. Additionally, strategies for applying epigenetics data analysis results to disease diagnosis, prognosis, and case studies are included in order to provide thorough and translational comprehension and applicability. The book is a valuable resource for computer scientists, mathematicians, and statisticians interested in bioinformatics and computational biology approaches to epigenetic data analysis, as well as geneticists who are looking to improve their knowledge of computational analytics for their research. Explains the computational methods inferring features of epigenetic marks; Describes the basic computational methods for understanding and deciphering chromatin signatures at the primary organization level; Offers example publications and case studies to show the range of possible applications of the computational analyses of epigenetics data.

Non coding RNAs in Complex Diseases

Non coding RNAs in Complex Diseases Book
Author : Xia Li,Juan Xu,Yun Xiao,Shangwei Ning,Yunpeng Zhang
Publisher : Springer
Release : 2018-09-06
ISBN : 9811307199
Language : En, Es, Fr & De

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Book Description :

This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across ncRNAs, ncRNAs acted as competing regulators to mediate the expression of protein-coding genes, non-coding RNAs mediated risk pathways,and their contributions to drug target predictions. The generally used data resources of ncRNAs are also listed in the end. This book provides important information on the current progress in the fast-moving fields of bioinformatics for regulatory ncRNAs. It provides a timely and useful reference for computational biologists, specifically with RNA interests, and other related areas. Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.

Toxicology and Epigenetics

Toxicology and Epigenetics Book
Author : Saura C. Sahu
Publisher : John Wiley & Sons
Release : 2012-08-23
ISBN : 1118349067
Language : En, Es, Fr & De

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Book Description :

Epigenetics is the study of both heritable and non-heritablechanges in the regulation of gene activity and expression thatoccur without an alteration in the DNA sequence. Thisdynamic and rapidly developing discipline is making its impactacross the biomedical sciences, in particular in toxicology whereepigenetic differences can mean that different individuals responddifferently to the same drug or chemical. Toxicology and Epigenetics reflects the multidimensionalcharacter of this emerging area of toxicology, describingcutting-edge molecular technologies to unravel epigenetic changes,the use of in vivo and in vitro models, as well asthe potential use of toxicological epigenetics in regulatoryenvironments. An international team of experts consider theinterplay between epigenetics and toxicology in a number of areas,including environmental, nutritional, pharmacological, andcomputational toxicology, nanomaterials, proteomics andmetabolomics, and cancer research. Topics covered include: environment, epigenetics and diseases DNA methylation and toxicogenomics chromatin at the intersection of disease and therapy epigenomic actions of environmental arsenicals environment, epigenetics and cardiovascular health toxicology, epigenetics and autoimmunity ocular epigenomics: potential sites of environmental impact indevelopment and disease nuclear RNA silencing and related phenomena in animals epigenomics – impact for drug safety sciences methods of global epigenomic profiling transcriptomics: applications in epigenetic toxicology Toxicology and Epigenetics is an essential insight intothe current trends and future directions of research in thisrapidly expanding field for investigators, toxicologists, riskassessors and regulators in academia, industry and government.

Computational Studies of Plant Bioactives in Epigenetic Modulation

Computational Studies of Plant Bioactives in Epigenetic Modulation Book
Author : Ravi Kapopara,Yogesh Jasrai,Himanshu Pandya
Publisher : LAP Lambert Academic Publishing
Release : 2012-04
ISBN : 9783848480562
Language : En, Es, Fr & De

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Book Description :

Cancer is a term that encompasses a complex group of more than 100 different types of diseases associated with uncontrolled cell division. Epigenetic events are alterations in gene expression without changes in DNA sequence and characteristic of heritability via cell division. Certainly, it is anticipated that aberrant changes bring about epigenetic control through chromatin modifying enzymes. This has an important bearing on future therapies for human diseases including cancer.

Computational Epigenomics

Computational Epigenomics Book
Author : Angela Yen
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

One of the fundamental aims of biology is to determine what lies at the root of differences across individuals, species, diseases, and cell types. Furthermore, the sequencing of genomes has revolutionized the ways in which scientists can investigate biological processes and disease pathways; new genome-wide, high-throughput experiments require computer scientists with a biological understanding to analyze and interpret the data to improve our understanding about life science. This provides us with a key opportunity to use computational techniques for new biological discoveries. While genetic variation plays an important role in influence phenotype, sequence alone cannot account for all differences: for example, different types of cells in an individual have varying function and attributes, but identical genetic makeup. This highlights the importance of studying epigenetic changes, which are dynamic chemical changes to and around the DNA. While the DNA of every cell in an individual is the same, the epigenetic context for that DNA varies from cell to cell. In this way, these epigenetic differences play a crucial role in gene regulation, with epigenetic changes both causing and recording regulatory mechanisms. In this thesis, we combine the power of computational, statistical, and data science approaches with the new wave of epigenetic data at a genome-wide level in a number of ways. First, in chapter 2, we demonstrate the importance of computational analysis at an epigenomic level by identifying an epigenomic signature of the olfactory receptor gene family that gives insight into the mechanism behind monogenic gene regulation. Next, in chapter 3, we explain our development of ChromDiff, a novel statistical and information theoretic computational methodology to identify chromatin state differences in groups of samples. In our methodology, we use correction for external covariates to isolate the relevant signal, and as a result, we find that our method outperforms existing computational methods, with further validation through randomized simulations. In chapter 4, we apply our methodology to characteristics including sex, developmental age, and tissue type, we unveil relevant chromatin states and genes that distinguish the groups of epigenomes, with further validation of our results through differential expression analysis and gene set enrichment. In chapter 5, we show the power of integrative analysis through the combination of DNA methylation data with chromatin state profiles, cell types, sample groups, experimental technologies, and histone mark data to reveal insightful epigenetic patterns and relationships. Finally, in chapter 6, we identify "hidden" or "unknown" covariates in epigenomic data by using agnostic principal component analysis on our samples to discover similarities between our known covariates and the identified components. In summation, our research highlights the importance of both algorithm development and method application for epigenomic questions, reaffirming the importance of interdisciplinary research that brings together cutting-edge techniques in computer science with appropriate biological hypotheses and data. While questions and analysis must be carefully paired in an informed manner to produce meaningful, interpretable, and believable results in computational biology, our work here provides a sampling of the vast potential for scientific discovery at the intersection of the fields of computer science and biology.

Epigenetics in Cardiovascular Disease

Epigenetics in Cardiovascular Disease Book
Author : Yvan Devaux,Emma Louise Robinson
Publisher : Academic Press
Release : 2021-03-06
ISBN : 012822259X
Language : En, Es, Fr & De

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Book Description :

Epigenetics in Cardiovascular Disease, a new volume in the Translational Epigenetics series, offers a comprehensive overview of the epigenetics mechanisms governing cardiovascular disease development, as well as instructions in research methods and guidance in pursing new studies. More than thirty international experts provide an (i) overview of the epigenetics mechanisms and their contribution to cardiovascular disease development, (i) high-throughput methods for RNA profiling including single-cell RNA-seq, (iii) the role of nucleic acid methylation in cardiovascular disease development, (iv) epigenetic actors as biomarkers and drug targets, (v) and the potential of epigenetics to advance personalized medicine. Here, readers will discover strategies to combat research challenges, improve quality of their epigenetic research and reproducibility of their findings. Additionally, discussion of assay and drug development for personalized healthcare pave the way for a new era of understanding in cardiovascular disease. Offers a thorough overview of role of epigenetics mechanisms in cardiovascular disease Includes guidance to improve research plans, experimental protocols design, quality and reproducibility of results in new epigenetics research Explores biomarkers and drug targets of therapeutic potential to advance personalized healthcare Features chapter contributions from a wide range of international researchers in the field

Computational Psychiatry

Computational Psychiatry Book
Author : Rodrick Wallace
Publisher : Springer
Release : 2017-04-20
ISBN : 3319539108
Language : En, Es, Fr & De

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Book Description :

This book explores mental disorders from a uniquely evolutionary perspective. Although there have been many attempts to mathematically model neural processes and, to some extent, their dysfunction, there is very little literature that models mental function within a sociocultural, socioeconomic, and environmental context. Addressing this gap in the extant literature, this book explores essential aspects of mental disorders, recognizing the ubiquitous role played by the exaptation of crosstalk between cognitive modules at many different scales and levels of organization, the missing heritability of complex diseases, and cultural epigenetics. Further, it introduces readers to valuable control theory tools that permit the exploration of the environmental induction of neurodevelopmental disorders, as well as the study of the synergism between culture, psychopathology and sleep disorders, offering a distinctively unique resource.

Epigenetics Methods

Epigenetics Methods Book
Author : Trygve Tollefsbol
Publisher : Academic Press
Release : 2020-07-08
ISBN : 0128194154
Language : En, Es, Fr & De

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Book Description :

In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used to study various epigenetic mechanisms, as employed in basic and translational research. Leading the reader from fundamental to more advanced methods, the book begins with thorough instruction in DNA methylation techniques and gene or locus-specific methylation analyses, followed by histone modification methods, chromatin evaluation, enzyme analyses of histone methylation, and studies of non-coding RNAs as epigenetic modulators. Recently developed techniques and technologies discussed include single-cell epigenomics, epigenetic editing, computational epigenetics, systems biology epigenetic methods, and forensic epigenetic approaches. Epigenetics methods currently in-development, and their implication for future research, are also considered in-depth. In addition, as with the wider life sciences, reproducibility across experiments, labs, and subdisciplines is a growing issue for epigenetics researchers. This volume provides consensus-driven methods instruction and overviews. Tollefsbol and contributing authors survey the range of existing methods; identify best practices, common themes, and challenges; and bring unity of approach to a diverse and ever-evolving field. Includes contributions by leading international investigators involved in epigenetic research and clinical and therapeutic application Integrates technology and translation with fundamental chapters on epigenetics methods, as well as chapters on more novel and advanced epigenetics methods Written at verbal and technical levels that can be understood by scientists and students alike Includes chapters on state-of-the-art techniques such as single-cell epigenomics, use of CRISPR/Cas9 for epigenetic editing, and epigenetics methods applied to forensics

Transcriptomics and Gene Regulation

Transcriptomics and Gene Regulation Book
Author : Jiaqian Wu
Publisher : Springer
Release : 2015-11-17
ISBN : 9401774501
Language : En, Es, Fr & De

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Book Description :

This volume focuses on modern computational and statistical tools for translational gene expression and regulation research to improve prognosis, diagnostics, prediction of severity, and therapies for human diseases. It introduces some of state of the art technologies as well as computational and statistical tools for translational bioinformatics in the areas of gene transcription and regulation, including the tools for next generation sequencing analyses, alternative spicing, the modeling of signaling pathways, network analyses in predicting disease genes, as well as protein and gene expression data integration in complex human diseases etc. The book is particularly useful for researchers and students in the field of molecular biology, clinical biology and bioinformatics, as well as physicians etc. Dr. Jiaqian Wu is assistant professor in the Vivian L. Smith Department of Neurosurgery and Center for Stem Cell and Regenerative Medicine, University of Texas Health Science Centre, Houston, TX, USA.​

Computational and Statistical Epigenomics

Computational and Statistical Epigenomics Book
Author : Andrew E. Teschendorff
Publisher : Springer
Release : 2015-05-12
ISBN : 940179927X
Language : En, Es, Fr & De

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Book Description :

This book introduces the reader to modern computational and statistical tools for translational epigenomics research. Over the last decade, epigenomics has emerged as a key area of molecular biology, epidemiology and genome medicine. Epigenomics not only offers us a deeper understanding of fundamental cellular biology, but also provides us with the basis for an improved understanding and management of complex diseases. From novel biomarkers for risk prediction, early detection, diagnosis and prognosis of common diseases, to novel therapeutic strategies, epigenomics is set to play a key role in the personalized medicine of the future. In this book we introduce the reader to some of the most important computational and statistical methods for analyzing epigenomic data, with a special focus on DNA methylation. Topics include normalization, correction for cellular heterogeneity, batch effects, clustering, supervised analysis and integrative methods for systems epigenomics. This book will be of interest to students and researchers in bioinformatics, biostatistics, biologists and clinicians alike. Dr. Andrew E. Teschendorff is Head of the Computational Systems Genomics Lab at the CAS-MPG Partner Institute for Computational Biology, Shanghai, China, as well as an Honorary Research Fellow at the UCL Cancer Institute, University College London, UK.

Twin and Family Studies of Epigenetics

Twin and Family Studies of Epigenetics Book
Author : Shuai Li,John Hopper
Publisher : Academic Press
Release : 2021-08-31
ISBN : 0128209526
Language : En, Es, Fr & De

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Book Description :

Twin and Family Studies of Epigenetics, Volume 29, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more. Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects. Offers a practical, interdisciplinary approach across epigenetics, epidemiology and various disease specialties Applies epigenetic twin and family studies to determine the relationship between epigenetics and mental illness, cancers, cardiovascular disease, diabetes, obesity and high blood pressure, among other diseases and disorders Features chapter contributions from a wide range of international researchers in the field

Epigenetics of the Immune System

Epigenetics of the Immune System Book
Author : Dieter Kabelitz,Jaydeep Bhat
Publisher : Academic Press
Release : 2020-07-03
ISBN : 0128179643
Language : En, Es, Fr & De

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Book Description :

Epigenetics of the Immune System focuses on different aspects of epigenetics and immunology, providing readers with the fundamental mechanisms relating to epigenetics and the immune system. This book provides in-depth information on immune cells as a toolbox in deciphering systematically regulated mechanisms using "omics" and computational biology approaches. In addition, the book presents the translational importance of epigenetics and the immune system in our understanding of pathophysiology in diseases and its therapeutic applications. Provides an overview of most important immune mechanisms, the current status of epigenetics, and how both of them are brought together Presents key principles of immune mechanisms in epigenetics, presenting current findings and key principles Features in-depth chapter contributions from a wide range of international researchers and specialists in immunology, translational medicine and epigenetics Merges two very large areas, covering the unique interrelatedness of epigenetics and immunology

Gene Environment Interaction Analysis

Gene Environment Interaction Analysis Book
Author : Sumiko Anno
Publisher : CRC Press
Release : 2016-03-30
ISBN : 9814669644
Language : En, Es, Fr & De

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Book Description :

Gene–environment (G × E) interaction analysis is a statistical method for clarifying G × E interactions applicable to a phenotype or a disease that is the result of interactions between genes and the environment. This book is the first to deal with the theme of G × E interaction analysis. It compiles and details cutting-edge research in bioinformatics and computational biology and will appeal to anyone involved in bioinformatics and computational biology.

11th International Conference on Practical Applications of Computational Biology Bioinformatics

11th International Conference on Practical Applications of Computational Biology   Bioinformatics Book
Author : Florentino Fdez-Riverola,Mohd Saberi Mohamad,Miguel Rocha,Juan F. De Paz,Tiago Pinto
Publisher : Springer
Release : 2017-06-19
ISBN : 3319608169
Language : En, Es, Fr & De

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Book Description :

Biological and biomedical research are increasingly driven by experimental techniques that challenge our ability to analyse, process and extract meaningful knowledge from the underlying data. The impressive capabilities of next-generation sequencing technologies, together with novel and constantly evolving, distinct types of omics data technologies, have created an increasingly complex set of challenges for the growing fields of Bioinformatics and Computational Biology. The analysis of the datasets produced and their integration call for new algorithms and approaches from fields such as Databases, Statistics, Data Mining, Machine Learning, Optimization, Computer Science and Artificial Intelligence. Clearly, Biology is more and more a science of information and requires tools from the computational sciences. In the last few years, we have seen the rise of a new generation of interdisciplinary scientists with a strong background in the biological and computational sciences. In this context, the interaction of researchers from different scientific fields is, more than ever, of foremost importance in boosting the research efforts in the field and contributing to the education of a new generation of Bioinformatics scientists. The PACBB’17 conference was intended to contribute to this effort and promote this fruitful interaction, with a technical program that included 39 papers spanning many different sub-fields in Bioinformatics and Computational Biology. Further, the conference promoted the interaction of scientists from diverse research groups and with a distinct background (computer scientists, mathematicians, biologists).

RNA Based Regulation in Human Health and Disease

RNA Based Regulation in Human Health and Disease Book
Author : Anonim
Publisher : Academic Press
Release : 2020-08-15
ISBN : 0128171944
Language : En, Es, Fr & De

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Book Description :

RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field

Computational Methods to Discern the Genetic Basis of Complex Disease

Computational Methods to Discern the Genetic Basis of Complex Disease Book
Author : Megan D Roytman
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Genome-wide association studies (GWAS) have identified thousands of regions in the genome containing risk variants for complex traits. Due to the correlation structure between ge- netic variants, there is a need for computational methods that can tease apart causal from non-causal variants in these implicated regions. This dissertation presents three statistical methods that aim to improve our detection of causal variants at risk regions and ultimately better our understanding of the genetic basis of complex disease. The first method aims to fine-map genetic regions impacting multiple correlated traits at once, employing the Multivariate Normal (MVN) distribution to jointly model association statistics at a risk region. The second method performs hierarchical fine-mapping on risk regions that show evidence for a SNP impacting gene expression through an epigenetic feature, such as histone modifi- cations. It uses both the MVN as well as the Matrix-variate Normal distribution to jointly model effects from SNP to epigenetic mark to gene expression. The third method builds on existing summary statistics imputation methods by integrating functional annotation data to improve prediction of associations at untyped SNPs.

Epigenetics of Aging

Epigenetics of Aging Book
Author : Trygve O. Tollefsbol
Publisher : Springer Science & Business Media
Release : 2009-11-11
ISBN : 9781441906397
Language : En, Es, Fr & De

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Book Description :

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Cancer and Noncoding RNAs

Cancer and Noncoding RNAs Book
Author : Jayprokas Chakrabarti,Sanga Mitra
Publisher : Academic Press
Release : 2017-10-13
ISBN : 0128134372
Language : En, Es, Fr & De

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Book Description :

Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies. Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies Features contributions by leading experts in the field