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Combination Therapy Against Multidrug Resistance

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Combination Therapy Against Multidrug Resistance

Combination Therapy Against Multidrug Resistance Book
Author : Mohmmad Younus Wani,Aijaz Ahmad
Publisher : Academic Press
Release : 2020-04-30
ISBN : 0128205784
Language : En, Es, Fr & De

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Book Description :

Combination Therapy against Multidrug Resistance explores the potential of combination therapy as an efficient strategy to combat multi-drug resistance. Multidrug resistance (MDR) occurs when microorganisms such as bacteria, fungi, viruses, and parasites are excessively exposed to antimicrobial drugs such as antibiotics, antifungals, or antivirals, and in response the microorganism undergoes mutations or develops different resistance mechanisms to combat the drug for its survival. MDR is becoming an increasingly serious problem in both developed and developing nations. Bacterial resistance to antibiotics has developed faster than the production of new antibiotics, making bacterial infections increasingly difficult to treat, and the same is true for a variety of other diseases. Combination therapy proves to be a promising strategy as it offers potential benefits such as a broad spectrum of efficacy, greater potency than the drugs used in monotherapy, improved safety and tolerability, and reduction in the number of resistant organisms. This book considers how combination therapy can be applied in multiple situations, including cancer, HIV, tuberculosis, fungal infections, and more. Combination Therapy Against Multidrug Resistance gathers the most relevant information on the prospects of combination therapy as a strategy to combat multridrug resistance and helping to motivate the industrial sector and government agencies to invest more in research and development of this strategy as a weapon to tackle the multidrug resistance problem. It will be useful to academics and researchers involved in the development of new antimicrobial or antiinfective agents and treatment strtategies to combat multidrug resistance. Clinicians and medical nurses working in the field of infection prevention and control (IPC) will also find the book relevant Explores strategic methods with investigation of both short- and long-term goals to combat multidrug resistance Presents a broad scope to understand fully the ways to apply combined therapy to multidrug resistance Provides an overview of combination therapy, but also includes specific cases such as cancer, tuberculosis, HIV and malaria

Combination Therapy Against Multidrug Resistance

Combination Therapy Against Multidrug Resistance Book
Author : Mohmmad Younus Wani,Aijaz Ahmad
Publisher : Academic Press
Release : 2020-06
ISBN : 9780128205761
Language : En, Es, Fr & De

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Book Description :

Combination Therapy Against Multidrug Resistance explores the potential of combination therapy as an efficient strategy to combat multi-drug resistance. The book considers how combination therapy can apply in multiple situations, including cancer, HIV, tuberculosis, fungal infections, and more. Sections cover the most relevant information on prospects of combination therapy as a strategy to combat multidrug resistance and help motivate the industrial sector and government agencies to invest more in research and development. This comprehensive resource is useful to academics and researchers involved in the development of new antimicrobial or anti-infective agents and treatment strategies to combat multidrug resistance. Explores strategic methods with investigation of both short- and long-term goals to combat multidrug resistance Presents a broad scope to help users fully understand how to apply combined therapy to multidrug resistance Provides an overview of combination therapy, but also includes specific cases such as cancer, tuberculosis, HIV and malaria

Antibiotic Combination Therapy Against Multidrug resistant Staphylococcus Epidermidis Biofilms and Broadening Antibiotic Spectrum Using Polyethylenimine

Antibiotic Combination Therapy Against Multidrug resistant Staphylococcus Epidermidis Biofilms and Broadening Antibiotic Spectrum Using Polyethylenimine Book
Author : Anh Kim Lam
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Antibiotic Combination Therapy Against Multidrug resistant Staphylococcus Epidermidis Biofilms and Broadening Antibiotic Spectrum Using Polyethylenimine book written by Anh Kim Lam, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Annals of the Academy of Medicine Singapore

Annals of the Academy of Medicine  Singapore Book
Author : Academy of Medicine (Singapore)
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Annals of the Academy of Medicine Singapore book written by Academy of Medicine (Singapore), available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Fighting Multidrug Resistance with Herbal Extracts Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts  Essential Oils and Their Components Book
Author : Kalpna D. Rakholiya,Mital J. Kaneria,Sumitra V. Chanda
Publisher : Elsevier Inc. Chapters
Release : 2013-05-24
ISBN : 0128066822
Language : En, Es, Fr & De

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Book Description :

Antibiotics are antimicrobial agents that are used to treat infectious diseases. The outbreak of pathogenic antibiotic-resistant strains illustrates our urgent need to search for new alternative sources of treatment. Hence, an attempt has been made in this review to list some plant extracts, essential/volatile oils, and their antimicrobial activity against different microorganisms using different methods, as well as synergistic effects (plant extract-plant extract, plant extract-essential oils, plant extract-conventional antibiotics, phytochemical-antibiotics, and essential oil-essential oil). Plant products and their active constituents are useful in the treatment of infectious diseases caused by multidrug-resistant microbes, food borne diseases caused by food spoiling microbes, and oral pathogens. Products derived from plants have the potential to control microbial growth in diverse situations, and specifically in the treatment of disease. The various aspects of this review may be helpful for the food, cosmetic, and pharmaceutical industries.

Towards Optimal Utilization of Drugs

Towards Optimal Utilization of Drugs Book
Author : Cyprian O. Onyeji
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Towards Optimal Utilization of Drugs book written by Cyprian O. Onyeji, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Exploiting Novel Combined Host and Pathogen Directed Therapies for Combating Bacterial Multidrug Resistance

Exploiting Novel Combined Host  and Pathogen Directed Therapies for Combating Bacterial Multidrug Resistance Book
Author : Maurizio Fraziano,Roberto Nisini,Gian Maria Rossolini,Marco Rinaldo Oggioni
Publisher : Frontiers Media SA
Release : 2020-12-30
ISBN : 2889663078
Language : En, Es, Fr & De

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Book Description :

Download Exploiting Novel Combined Host and Pathogen Directed Therapies for Combating Bacterial Multidrug Resistance book written by Maurizio Fraziano,Roberto Nisini,Gian Maria Rossolini,Marco Rinaldo Oggioni, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Optimizing Polymyxin Antibiotics Using Combination Therapy and Mechanism based Models

Optimizing Polymyxin Antibiotics Using Combination Therapy and Mechanism based Models Book
Author : Neang S. Ly
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The emergence of multidrug-resistant (MDR) Gram-negative 'superbugs' coupled with a rapid decline in the development of new antibiotics has led to a serious, global health crisis. Polymyxin antibiotics, which include polymyxin E (colistin) and polymyxin B, were introduced over 50 years ago and were seldom used due to nephrotoxicity. However, recently, the polymyxins have re-emerged in the clinic as an antibiotic of last-resort. There are increasing reports of polymyxin resistance and failure during polymyxin monotherapy. While polymyxin based combination therapies are a promising alternative, there are significant gaps regarding the optimal use of such combinations. The primary goal of this dissertation is to rationally optimize polymyxin combination therapy based on pharmacokinetic/pharmacodynamic (PK/PD) principles. Menchanism-based (PK/PD) models (MBMs) were employed to evaluate mechanisms of antibiotic synergy. A secondary goal is to define the mechanisms of polymyxin tolerance and resistance utilizing genetically modified knockout strains and to develop MBMs that quantify the impact of bacterial regulatory systems including quorum sensing mechanisms on antibiotic PD.

Fighting Multidrug Resistance with Herbal Extracts Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts  Essential Oils and Their Components Book
Author : Kateryna Volodymyrivna Kon,Mahendra Kumar Rai
Publisher : Elsevier Inc. Chapters
Release : 2013-05-24
ISBN : 0128066814
Language : En, Es, Fr & De

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Book Description :

High prevalence of multidrug-resistant microorganisms in the etiologic structure of different infectious processes significantly decreases the effectiveness of the treatment and enhances the probability of an unfavorable outcome from the infection. Combinations between antibiotics and other antimicrobial agents represent one of the most promising approaches for combating multidrug-resistant bacteria. A high therapeutic potential exists for combinations of antibiotics and natural antimicrobial substances with complex mechanisms of action and multiple healing properties, such as plant essential oils. The purpose of the present chapter is to review published studies on antibiotic-essential oil combinations and discuss the prospects for future studies. In general, many studies have shown the potential for essential oils to act synergistically with antibiotics in vitro. The main proposed mechanism of this beneficial effect is through inhibition of efflux pumps by some essential oils, which restores the activity of the antibiotic. Future efforts should be directed into further studies of antibiotic-essential oil combinations against multidrug-resistant bacteria, with an emphasis on understanding the mechanisms of the produced effect. Combinations of essential oils with different types of antimicrobial agents, such as bacteriophages, nanoparticles, and quorum-sensing inhibitors, require greater attention and are worthy of future investigations.

Japan s Official Development Assistance White Paper

Japan s Official Development Assistance White Paper Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Japan s Official Development Assistance White Paper book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Journal of the National Cancer Institute

Journal of the National Cancer Institute Book
Author : Anonim
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Journal of the National Cancer Institute book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Ochsner Clinic Reports on Serious Hospital Infections

Ochsner Clinic Reports on Serious Hospital Infections Book
Author : George A. Pankey
Publisher : Handbooks in Health Care Company
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Ochsner Clinic Reports on Serious Hospital Infections book written by George A. Pankey, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Chemical Abstracts

Chemical Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Chemical Abstracts book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Changing Care

Changing Care Book
Author : Donald Jeffries
Publisher : Unknown
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Changing Care book written by Donald Jeffries, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Fighting Multidrug Resistance with Herbal Extracts Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts  Essential Oils and Their Components Book
Author : Román Yesid Ramírez Rueda
Publisher : Elsevier Inc. Chapters
Release : 2013-05-24
ISBN : 0128066733
Language : En, Es, Fr & De

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Book Description :

Methicillin-resistant Staphylococcus aureus (MRSA) is currently one of the most common causes of serious infections, in both hospital and community environments. This type of resistance was discovered in the 1960s, and now (50 years later) it has not been possible to develop an effective therapy to fight against it. This chapter compiles the results of several studies demonstrating the activity (mainly in vitro) of various extracts, essential oils, and plant-derived molecules that can act alone or in combination against MRSA. In addition, natural alternatives (other than from plants) being studied for the same purpose are described. Finally, the important role of phytotherapy in the development of new therapies against multidrug-resistant bacteria such as MRSA is emphasized.

The Journal of Infectious Diseases

The Journal of Infectious Diseases Book
Author : Anonim
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Journal of Infectious Diseases book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Antibiotic Essentials 2007

Antibiotic Essentials  2007 Book
Author : Burke A. Cunha
Publisher : Unknown
Release : 2007-06
ISBN : 9781890114688
Language : En, Es, Fr & De

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Book Description :

Download Antibiotic Essentials 2007 book written by Burke A. Cunha, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pharmacotherapy

Pharmacotherapy Book
Author : Anonim
Publisher : Unknown
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Pharmacotherapy book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Fighting Multidrug Resistance with Herbal Extracts Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts  Essential Oils and Their Components Book
Author : T.O. Lawal,K.K. Soni,B.A. Adeniyi,B.J. Doyle,G.B. Mahady
Publisher : Elsevier Inc. Chapters
Release : 2013-05-24
ISBN : 0128066806
Language : En, Es, Fr & De

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Book Description :

High prevalence of multidrug-resistant microorganisms in the etiologic structure of different infectious processes significantly decreases the effectiveness of the treatment and enhances the probability of an unfavorable outcome from the infection. Combinations between antibiotics and other antimicrobial agents represent one of the most promising approaches for combating multidrug-resistant bacteria. A high therapeutic potential exists for combinations of antibiotics and natural antimicrobial substances with complex mechanisms of action and multiple healing properties, such as plant essential oils. The purpose of the present chapter is to review published studies on antibiotic-essential oil combinations and discuss the prospects for future studies. In general, many studies have shown the potential for essential oils to act synergistically with antibiotics in vitro. The main proposed mechanism of this beneficial effect is through inhibition of efflux pumps by some essential oils, which restores the activity of the antibiotic. Future efforts should be directed into further studies of antibiotic-essential oil combinations against multidrug-resistant bacteria, with an emphasis on understanding the mechanisms of the produced effect. Combinations of essential oils with different types of antimicrobial agents, such as bacteriophages, nanoparticles, and quorum-sensing inhibitors, require greater attention and are worthy of future investigations.

Pharmacology

Pharmacology Book
Author : H. P. Rang,M. Maureen Dale,J. M. Ritter
Publisher : Unknown
Release : 1999
ISBN : 9780443059742
Language : En, Es, Fr & De

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Book Description :

This textbook for medical and science students emphasises the mechanisms by which drugs act and relates these to pharmacological effects and clinical uses. It sets out for the reader a route from a molecular understanding of receptors and drug actions, to the uses of groups of drugs.