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Combination Therapy Against Multidrug Resistance

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Combination Therapy Against Multidrug Resistance

Combination Therapy Against Multidrug Resistance Book
Author : Mohmmad Younus Wani,Aijaz Ahmad
Publisher : Academic Press
Release : 2020-04-30
ISBN : 0128205784
Language : En, Es, Fr & De

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Book Description :

Combination Therapy against Multidrug Resistance explores the potential of combination therapy as an efficient strategy to combat multi-drug resistance. Multidrug resistance (MDR) occurs when microorganisms such as bacteria, fungi, viruses, and parasites are excessively exposed to antimicrobial drugs such as antibiotics, antifungals, or antivirals, and in response the microorganism undergoes mutations or develops different resistance mechanisms to combat the drug for its survival. MDR is becoming an increasingly serious problem in both developed and developing nations. Bacterial resistance to antibiotics has developed faster than the production of new antibiotics, making bacterial infections increasingly difficult to treat, and the same is true for a variety of other diseases. Combination therapy proves to be a promising strategy as it offers potential benefits such as a broad spectrum of efficacy, greater potency than the drugs used in monotherapy, improved safety and tolerability, and reduction in the number of resistant organisms. This book considers how combination therapy can be applied in multiple situations, including cancer, HIV, tuberculosis, fungal infections, and more. Combination Therapy Against Multidrug Resistance gathers the most relevant information on the prospects of combination therapy as a strategy to combat multridrug resistance and helping to motivate the industrial sector and government agencies to invest more in research and development of this strategy as a weapon to tackle the multidrug resistance problem. It will be useful to academics and researchers involved in the development of new antimicrobial or antiinfective agents and treatment strtategies to combat multidrug resistance. Clinicians and medical nurses working in the field of infection prevention and control (IPC) will also find the book relevant Explores strategic methods with investigation of both short- and long-term goals to combat multidrug resistance Presents a broad scope to understand fully the ways to apply combined therapy to multidrug resistance Provides an overview of combination therapy, but also includes specific cases such as cancer, tuberculosis, HIV and malaria

Antibiotic Combination Therapy Against Multidrug resistant Staphylococcus Epidermidis Biofilms and Broadening Antibiotic Spectrum Using Polyethylenimine

Antibiotic Combination Therapy Against Multidrug resistant Staphylococcus Epidermidis Biofilms and Broadening Antibiotic Spectrum Using Polyethylenimine Book
Author : Anh Kim Lam
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Antibiotic Combination Therapy Against Multidrug resistant Staphylococcus Epidermidis Biofilms and Broadening Antibiotic Spectrum Using Polyethylenimine book written by Anh Kim Lam, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Exploiting Novel Combined Host and Pathogen Directed Therapies for Combating Bacterial Multidrug Resistance

Exploiting Novel Combined Host  and Pathogen Directed Therapies for Combating Bacterial Multidrug Resistance Book
Author : Maurizio Fraziano,Roberto Nisini,Gian Maria Rossolini,Marco Rinaldo Oggioni
Publisher : Frontiers Media SA
Release : 2020-12-30
ISBN : 2889663078
Language : En, Es, Fr & De

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Book Description :

Download Exploiting Novel Combined Host and Pathogen Directed Therapies for Combating Bacterial Multidrug Resistance book written by Maurizio Fraziano,Roberto Nisini,Gian Maria Rossolini,Marco Rinaldo Oggioni, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Fighting Multidrug Resistance with Herbal Extracts Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts  Essential Oils and Their Components Book
Author : Mahendra Rai,Kateryna Kon
Publisher : Academic Press
Release : 2013-05-24
ISBN : 0124017088
Language : En, Es, Fr & De

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Book Description :

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components offers scientists a single source aimed at fighting specific multidrug-resistant (MDR) microorganisms such as bacteria, protozoans, viruses and fungi using natural products. This essential reference discusses herbal extracts and essential oils used or under investigation to treat MDR infections, as well as those containing antimicrobial activity that could be of potential interest in future studies against MDR microorganisms. The need to combat multidrug-resistant microorganisms is an urgent one and this book provides important coverage of mechanism of action, the advantages and disadvantages of using herbal extracts, essential oils and their components and more to aid researchers in effective antimicrobial drug discovery Addresses the need to develop safe and effective approaches to coping with resistance to all classes of antimicrobial drugs Provides readers with current evidence-based content aimed at using herbal extracts and essential oils in antimicrobial drug development Includes chapters devoted to the activity of herbal products against herpes, AIDS, tuberculosis, drug-resistant cancer cells and more

Antimicrobials and Anticancers of Bacterial Origins

Antimicrobials and Anticancers of Bacterial Origins Book
Author : Bingyun Li
Publisher : Frontiers Media SA
Release : 2020-06-26
ISBN : 2889638065
Language : En, Es, Fr & De

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Book Description :

Download Antimicrobials and Anticancers of Bacterial Origins book written by Bingyun Li, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Antibiotic Materials in Healthcare

Antibiotic Materials in Healthcare Book
Author : Kokkarachedu Varaprasad,Vimala Kanikireddy,Rotimi Sadiku
Publisher : Academic Press
Release : 2020-05-22
ISBN : 012822536X
Language : En, Es, Fr & De

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Book Description :

Antibiotic Materials in Healthcare provides significant information on antibiotic related issues, accurate solutions, and recent investigative information for health-related applications. In addition, the book addresses the design and development of antibiotics with advanced (physical, chemical and biological) properties, an analysis of materials, in vivo and in vitro applications, and their biomedical applications for healthcare. Provides information on all aspects of antibiotic related issues Offers a balanced synthesis of basic and clinical science for each individual case, presenting clinical courses and detailed microbiological information for each infection Describes the prevalence and incidence of global issues and current therapeutic approaches

Antibiotics and Bacterial Resistance

Antibiotics and Bacterial Resistance Book
Author : Wiley
Publisher : John Wiley & Sons
Release : 2013-01-14
ISBN : 1118580915
Language : En, Es, Fr & De

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Book Description :

The need for novel antibiotics is greater now than perhaps anytime since the pre-antibiotic era. Indeed, the recent collapse ofmany pharmaceutical antibacterial groups, combined with theemergence of hypervirulent and pan-antibiotic-resistant bacteriahas severely compromised infection treatment options and led todramatic increases in the incidence and severity of bacterialinfections. This collection of reviews and laboratory protocols gives thereader an introduction to the causes of antibiotic resistance, thebacterial strains that pose the largest danger to humans (i.e.,streptococci, pneumococci and enterococci) and the antimicrobialagents used to combat infections with these organisms. Some newavenues that are being investigated for antibiotic development arealso discussed. Such developments include the discovery of agentsthat inhibit bacterial RNA degradation, the bacterial ribosome, andstructure-based approaches to antibiotic drug discovery. Two laboratory protocols are provided to illustrate differentstrategies for discovering new antibiotics. One is a bacterialgrowth inhibition assay to identify inhibitors of bacterial growththat specifically target conditionally essential enzymes in thepathway of interest. The other protocol is used to identifyinhibitors of bacterial cell-to-cell signaling. This e-book — a curated collection from eLS, WIREs, andCurrent Protocols — offers a fantastic introduction to thefield of antibiotics and antibiotic resistance for students orinterdisciplinary collaborators. Table of Contents: Introduction Antibiotics and the Evolution of Antibiotic Resistance eLS Jose L Martinez, Fernando Baquero Antimicrobials Against Streptococci, Pneumococci andEnterococci eLS Susan Donabedian, Adenike Shoyinka Techniques & Applications RNA decay: a novel therapeutic target in bacteria WIREs RNA Tess M. Eidem, Christelle M. Roux, Paul M. Dunman Antibiotics that target protein synthesis WIREs RNA Lisa S. McCoy, Yun Xie, Yitzhak Tor Methods High-Throughput Assessment of Bacterial Growth Inhibition byOptical Density Measurements Current Protocols Chemical Biology Jennifer Campbell Structure-Based Approaches to Antibiotic Drug Discovery Current Protocols Microbiology George Nicola, Ruben Abagyan Novel Approaches to Bacterial Infection Therapy by Interferingwith Cell-to-Cell Signaling Current Protocols Microbiology David A. Rasko, Vanessa Sperandio

Drug Discovery Targeting Drug Resistant Bacteria

Drug Discovery Targeting Drug Resistant Bacteria Book
Author : Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta
Publisher : Academic Press
Release : 2020-05
ISBN : 0128184809
Language : En, Es, Fr & De

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Book Description :

Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful.

Beyond Antimicrobials Non Traditional Approaches to Combating Multidrug Resistant Bacteria

Beyond Antimicrobials  Non Traditional Approaches to Combating Multidrug Resistant Bacteria Book
Author : Natalia V. Kirienko,Laurence Rahme,You-Hee Cho
Publisher : Frontiers Media SA
Release : 2019-12-24
ISBN : 2889632563
Language : En, Es, Fr & De

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Book Description :

Download Beyond Antimicrobials Non Traditional Approaches to Combating Multidrug Resistant Bacteria book written by Natalia V. Kirienko,Laurence Rahme,You-Hee Cho, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Antibiotic Resistance

Antibiotic Resistance Book
Author : Kateryna Kon,Mahendra Rai
Publisher : Academic Press
Release : 2016-06-14
ISBN : 0128036680
Language : En, Es, Fr & De

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Book Description :

Antibiotic Resistance: Mechanisms and New Antimicrobial Approaches discusses up-to-date knowledge in mechanisms of antibiotic resistance and all recent advances in fighting microbial resistance such as the applications of nanotechnology, plant products, bacteriophages, marine products, algae, insect-derived products, and other alternative methods that can be applied to fight bacterial infections. Understanding fundamental mechanisms of antibiotic resistance is a key step in the discovery of effective methods to cope with resistance. This book also discusses methods used to fight antibiotic-resistant infection based on a deep understanding of the mechanisms involved in the development of the resistance. Discusses methods used to fight antibiotic-resistant infection based on a deep understanding of mechanisms involved in the development of the resistance Provides information on modern methods used to fight antibiotic resistance Covers a wide range of alternative methods to fight bacterial resistance, offering the most complete information available Discusses both newly emerging trends and traditionally applied methods to fight antibiotic resistant infections in light of recent scientific developments Offers the most up-to-date information in fighting antibiotic resistance Includes involvement of contributors all across the world, presenting questions of interest to readers of both developed and developing countries

Optimizing Polymyxin Antibiotics Using Combination Therapy and Mechanism based Models

Optimizing Polymyxin Antibiotics Using Combination Therapy and Mechanism based Models Book
Author : Neang S. Ly
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The emergence of multidrug-resistant (MDR) Gram-negative 'superbugs' coupled with a rapid decline in the development of new antibiotics has led to a serious, global health crisis. Polymyxin antibiotics, which include polymyxin E (colistin) and polymyxin B, were introduced over 50 years ago and were seldom used due to nephrotoxicity. However, recently, the polymyxins have re-emerged in the clinic as an antibiotic of last-resort. There are increasing reports of polymyxin resistance and failure during polymyxin monotherapy. While polymyxin based combination therapies are a promising alternative, there are significant gaps regarding the optimal use of such combinations. The primary goal of this dissertation is to rationally optimize polymyxin combination therapy based on pharmacokinetic/pharmacodynamic (PK/PD) principles. Menchanism-based (PK/PD) models (MBMs) were employed to evaluate mechanisms of antibiotic synergy. A secondary goal is to define the mechanisms of polymyxin tolerance and resistance utilizing genetically modified knockout strains and to develop MBMs that quantify the impact of bacterial regulatory systems including quorum sensing mechanisms on antibiotic PD.

Challenges to Tackling Antimicrobial Resistance Economic and Policy Responses

Challenges to Tackling Antimicrobial Resistance Economic and Policy Responses Book
Author : OECD,World Health Organization
Publisher : OECD Publishing
Release : 2020-04-01
ISBN : 1108864120
Language : En, Es, Fr & De

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Book Description :

Antimicrobial resistance (AMR) is a biological mechanism whereby a microorganism evolves over time to develop the ability to become resistant to antimicrobial therapies such as antibiotics. The drivers of and potential solutions to AMR are complex, often spanning multiple sectors. The internationally recognized response to AMR advocates for a ‘One Health’ approach, which requires policies to be developed and implemented across human, animal, and environmental health.

Combination Therapy of Aids

Combination Therapy of Aids Book
Author : Erik De Clercq,Anne-Mieke Vandamme
Publisher : Springer Science & Business Media
Release : 2004
ISBN : 9783764366001
Language : En, Es, Fr & De

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Book Description :

An extensive assessment of combination therapy of AIDS. Main focus is put on the Highly Active Antiretroviral Therapy (HAART) but other therapies like salvage therapy are also discussed. The chapters cover efficacy, treatment, causes of treatment failure, clinical care, guidelines, pharmacology. The volume closes with an outlook on future perspectives.

Antibiotics in Laboratory Medicine

Antibiotics in Laboratory Medicine Book
Author : Daniel Amsterdam
Publisher : Lippincott Williams & Wilkins
Release : 2014-08-08
ISBN : 1469883635
Language : En, Es, Fr & De

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Book Description :

Antibiotics in Laboratory Medicine has been a mainstay resource for practitioners/providers, investigators, and pharmaceutical researchers of new anti-infective compounds for the past 30 years. This edition includes new chapters on the predictive value of in vitro laboratory testing and the improvement of patient care in the hospital environment through antimicrobial stewardship.

Drug Resistance in Bacteria Fungi Malaria and Cancer

Drug Resistance in Bacteria  Fungi  Malaria  and Cancer Book
Author : Gunjan Arora,Andaleeb Sajid,Vipin Chandra Kalia
Publisher : Springer
Release : 2017-03-21
ISBN : 3319486837
Language : En, Es, Fr & De

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Book Description :

This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer.Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased excessively in last century. The advances in chemistry and biology have helped researchers to identify the drugs that have improved treatment of many diseases. The primary factor for treatment of these diseases is dependent on the efficacy of drugs available. The development of resistance to these drugs is one of the major hindrances. Although there are number of books available on this topic, “drug resistance” biology across kingdoms has never been discussed in a coherent way.

Introduction to Basics of Pharmacology and Toxicology

Introduction to Basics of Pharmacology and Toxicology Book
Author : Abialbon Paul,Nishanthi Anandabaskar,Jayanthi Mathaiyan,Gerard Marshall Raj
Publisher : Springer Nature
Release : 2021-03-13
ISBN : 9813360097
Language : En, Es, Fr & De

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Book Description :

This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.

Fighting Multidrug Resistance with Herbal Extracts Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts  Essential Oils and Their Components Book
Author : Kalpna D. Rakholiya,Mital J. Kaneria,Sumitra V. Chanda
Publisher : Elsevier Inc. Chapters
Release : 2013-05-24
ISBN : 0128066822
Language : En, Es, Fr & De

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Book Description :

Antibiotics are antimicrobial agents that are used to treat infectious diseases. The outbreak of pathogenic antibiotic-resistant strains illustrates our urgent need to search for new alternative sources of treatment. Hence, an attempt has been made in this review to list some plant extracts, essential/volatile oils, and their antimicrobial activity against different microorganisms using different methods, as well as synergistic effects (plant extract-plant extract, plant extract-essential oils, plant extract-conventional antibiotics, phytochemical-antibiotics, and essential oil-essential oil). Plant products and their active constituents are useful in the treatment of infectious diseases caused by multidrug-resistant microbes, food borne diseases caused by food spoiling microbes, and oral pathogens. Products derived from plants have the potential to control microbial growth in diverse situations, and specifically in the treatment of disease. The various aspects of this review may be helpful for the food, cosmetic, and pharmaceutical industries.

Antibiofilm Agents

Antibiofilm Agents Book
Author : Kendra P. Rumbaugh,Iqbal Ahmad
Publisher : Springer Science & Business Media
Release : 2014-05-08
ISBN : 3642538339
Language : En, Es, Fr & De

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Book Description :

This book provides a survey of recent advances in the development of antibiofilm agents for clinical and environmental applications. The fact that microbes exist in structured communities called biofilms has slowly become accepted within the medical community. We now know that over 80% of all infectious diseases are biofilm-related; however, significant challenges still lie in our ability to diagnose and treat these extremely recalcitrant infections. Written by experts from around the globe, this book offers a valuable resource for medical professionals seeking to treat biofilm-related disease, academic and industry researchers interested in drug discovery and instructors who teach courses on microbial pathogenesis and medical microbiology.

Contemporary Topics of Pneumonia

Contemporary Topics of Pneumonia Book
Author : Zissis Chroneos
Publisher : BoD – Books on Demand
Release : 2017-12-20
ISBN : 9535137077
Language : En, Es, Fr & De

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Book Description :

Pneumonia is an inflammatory disease of the air sacs and surrounding interstitium caused by infectious agents or by endogenous inflammatory tissue disorder termed interstitial pneumonia. The present book covers contemporary topics of community, hospital, and health care-related bacterial and viral pneumonia in the setting of drug resistance, environmental exposures, climate change, hormonal influences, and gender. The topic of interstitial pneumonia is brought under the lens of an immune-related connective tissue disease.

Photodynamic Therapy

Photodynamic Therapy Book
Author : Natalia Mayumi Inada,Hilde Harb Buzzá,Kate Cristina Blanco,Lucas Danilo Dias,Giulia Kassab
Publisher : BoD – Books on Demand
Release : 2021-05-05
ISBN : 1839680601
Language : En, Es, Fr & De

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Book Description :

Today, in the face of resistant microorganisms, aggressive cancers unresponsive to conventional treatments, and the COVID-19 pandemic, the need for advanced and innovative protocols for combating and treating disease is paramount. This book presents basic concepts of photodynamic therapy along with data from clinical research on its use in treating oncologic and other diseases. It also presents innovative strategies in photodynamic therapy, including information on polymer nanoparticles. This book was prepared with great care and by many valuable hands so that we can expand the dissemination of Photodynamic Therapy, as well as motivate for new research.