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Colorectal Neoplasia And The Colorectal Microbiome

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Colorectal Neoplasia and the Colorectal Microbiome

Colorectal Neoplasia and the Colorectal Microbiome Book
Author : Martin H. Floch
Publisher : Academic Press
Release : 2020-08-15
ISBN : 0128225610
Language : En, Es, Fr & De

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Book Description :

Colorectal Neoplasia and the Microbiome: Dysplasia, Probiotics, and Fusobacteria provides foundational knowledge on the gut microbiome and evidence for an association with colorectal neoplasia. It covers the role of microbiota in causing adenomatous polyps and colorectal cancer as well as the modulatory effect of diet and probiotics. Chapters explain a foundational history of microbiology in the colon, the epidemiology of colon polyps and cancer, dysbiosis, the role of immunology and bacteria, and the diet. The book combines medical and scientific aspects to show mechanistic aspects between microbiota and hosts, clearly presenting the association between microbiota, colonic lesions and possible causal links. The book is essential reading for everyone working with human microbiota including basic scientists, physiologists of the intestine, experts in intestinal microbiota, gastroenterologists, oncologists and surgeon. Provides foundational background on the complete history of microbiology in the colon Offers thorough coverage of the connection between fusobacterium nucleatum, diet and bacteria on colon health Presents the connection between immunology and bacteria in the colon

Inflammation Infection and Microbiome in Cancers

Inflammation  Infection  and Microbiome in Cancers Book
Author : Jun Sun
Publisher : Springer Nature
Release : 2021-04-20
ISBN : 3030679519
Language : En, Es, Fr & De

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Book Description :

This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers. Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes. This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists.

Inflammation and Cancer

Inflammation and Cancer Book
Author : Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Publisher : Springer
Release : 2014-05-12
ISBN : 3034808372
Language : En, Es, Fr & De

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Book Description :

This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

The Gut Microbiome in Health and Disease

The Gut Microbiome in Health and Disease Book
Author : Dirk Haller
Publisher : Springer
Release : 2018-07-27
ISBN : 3319905457
Language : En, Es, Fr & De

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Book Description :

The book provides an overview on how the gut microbiome contributes to human health. The readers will get profound knowledge on the connection between intestinal microbiota and immune defense systems. The tools of choice to study the ecology of these highly-specialized microorganism communities such as high-throughput sequencing and metagenomic mining will be presented. In addition the most common diseases associated to the composition of the gut flora are discussed in detail. The book will address researchers, clinicians and advanced students working in biomedicine, microbiology and immunology.

Multidisciplinary Approach for Colorectal Cancer

Multidisciplinary Approach for Colorectal Cancer Book
Author : Keun-Yeong Jeong
Publisher : BoD – Books on Demand
Release : 2019-12-18
ISBN : 1789843995
Language : En, Es, Fr & De

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Book Description :

A multidisciplinary understanding of the various processes leading to colorectal cancer progression is important for creating promising methods of therapy. Therefore it is necessary to scrutinize the progression of cancer and the therapeutic process through various academic theories. This book examines colorectal cancer - its prevention, pathogenesis, and treatment - through a multidisciplinary lens in an effort to advance understanding of the disease and improve therapeutic efficacy.

Colonic Microbiota Nutrition and Health

Colonic Microbiota  Nutrition and Health Book
Author : G.R. Gibson,M.B. Roberfroid
Publisher : Springer Science & Business Media
Release : 2013-03-14
ISBN : 9401710791
Language : En, Es, Fr & De

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Book Description :

1 2 MARCEL B. ROBERFROID AND GLENN R. GIBSON 1 Universite Catholique de Louvain, Department of Pharmaceutical Sciences, Avenue Mounier 73, B-1200 Brussels, BELGIUM 2 Food Microbial Sciences Unit, Department of Food Science and Technology, The University of Reading, Reading, UK It is clear that diet fulfils a number of important human requirements. These include the provision of sufficient nutrients to meet the requirements of essential metabolic pathways, as well as the sensory (and social) values associated with eating. It is also evident that diet may control and modulate various body functions in a manner that can reduce the risk of certain diseases. This very broad view of nutrition has led to the development of foodstuffs with added "functionality". Many different definitions of functional foods have arisen. Most of these complicate the simple issue that a functional food is merely a dietary ingredient(s) that can have positive properties above its normal nutritional value. Other terms used to describe such foods include vitafoods, nutraceuticals, pharmafoods, foods for specified health use, health foods, designer foods, etc. Despite some trepidation, the concept has recently attracted much interest through a vast number of articles in both the popular and scientific media.

Gut Microbiome Related Diseases and Therapies

Gut Microbiome Related Diseases and Therapies Book
Author : Maria Gazouli,George Theodoropoulos
Publisher : Springer Nature
Release : 2021-04-24
ISBN : 3030596427
Language : En, Es, Fr & De

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Book Description :

This book reviews recent knowledge of the role of gut microbiome in health and disease. It covers extensive topics for several diseases, including metabolic-related diseases, allergies, gastrointestinal diseases, psychiatric diseases, and cancer, while also discussing therapeutic approaches by microbiota modification. Comprehensive and cutting-edge, Gut Microbiome-Related Diseases and Therapies deepens a reader’s theoretical expertise in gut microbiome. Graduate and postdoctoral students, medical doctors, and biomedical researchers will benefit from this book.

Microbiome and Cancer

Microbiome and Cancer Book
Author : Erle S. Robertson
Publisher : Springer
Release : 2019-02-20
ISBN : 3030041557
Language : En, Es, Fr & De

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Book Description :

This book ventures into a new and exciting area of discovery that directly ties our current knowledge of cancer to the discovery of microorganisms associated with different types of cancers. Recent studies demonstrate that microorganisms are directly linked to the establishment of cancers and that they can also contribute to the initiation, as well as persistence of, the cancers. Microbiome and Cancer covers the current knowledge of microbiome and its association with human cancers. It provides important reading for novices, senior undergraduates in cancer and microbiology, graduate students, junior investigators, residents, fellows and established investigators in the fields of cancer and microbiology. We cover areas related to known, broad concepts in microbiology and how they can relate to the ongoing discoveries of the micro-environment and the changes in the metabolic and physiologic states in that micro-environment, which are important for the ongoing nurturing and survival of the poly-microbial content that dictates activities in that micro-environment. We cover the interactions of microorganisms associated with gastric carcinomas, which are important for driving this particular cancer. Additional areas include oral cancers, skin cancers, ovarian cancers, breast cancers, nasopharyngeal cancers, lung cancers, mesotheliomas, Hodgkin’s and non-Hodgkin’s lymphomas, glioblastoma multiforme, hepatocellular carcinomas, as well as the inflammatory response related to the infectious agents in cancers. This book covers the metabolic changes that occur because of infection and their support for development of cancers, chronic infection and development of therapeutic strategies for detection and control of the infection. The field of microbiome research has exploded over the last five years, and we are now understanding more and more about the context in which microorganisms can contribute to the onset of cancers in humans. The field of microbiome research has demonstrated that the human body has specific biomes for tissues and that changes in these biomes at the specific organ sites can result in disease. These changes can result in dramatic differences in metabolic shifts that, together with genetic mutations, will produce the perfect niche for establishment of the particular infection programmes in that organ site. We are just beginning to understand what those changes are and how they influence the disease state. Overall, we hope to bring together the varying degrees of fluctuations in the microbiome at the major organ sites and how these changes affect the normal cellular processes because of dysregulation, leading to proliferation of the associated tissues.

Mechanisms Underlying Host Microbiome Interactions in Pathophysiology of Human Diseases

Mechanisms Underlying Host Microbiome Interactions in Pathophysiology of Human Diseases Book
Author : Jun Sun,Pradeep K. Dudeja
Publisher : Springer
Release : 2018-01-26
ISBN : 149397534X
Language : En, Es, Fr & De

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Book Description :

Only recently have we begun to appreciate the role of microbiome in health and disease. Environmental factors and change of life style including diet significantly shape human microbiome that in turn appears to modify gut barrier function affecting nutrient & electrolyte absorption and inflammation. Approaches that can reverse the gut dysbiosis represent as reasonable and novel strategies for restoring the balance between host and microbes. In the book, we offer summary and discussion on the advances in understanding of pathophysiological mechanisms of microbial host interactions in human diseases. We will not only discuss intestinal bacterial community, but also viruses, fungi and oral microbiome. Microbiome studies will facilitate diagnosis, functional studies, drug development and personalized medicine. Thus, this book will further highlight the microbiome in the context of health and disease, focusing on mechanistic concepts that underlie the complex relationships between host and microbes.

Novel Approaches to Colorectal Cancer

Novel Approaches to Colorectal Cancer Book
Author : Anonim
Publisher : Academic Press
Release : 2021-06-18
ISBN : 0128240792
Language : En, Es, Fr & De

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Book Description :

Novel Approaches to Colorectal Cancer, Volume 151 in the Advances in Cancer Research series, is composed of 11 reviews covering state-of-the-art research relating to the etiology, diagnosis, prevention and treatment of colorectal cancer. The book's chapters were written by recognized experts in the field, and include sections on molecular biomarkers in diagnosis and therapy, the interplay of diet, lifestyle, and the microbiome, early-age onset disease, mutational signature analysis, challenges in early detection, immunotherapy, organoid technology, the role of epigenetic alterations, disparities in minority populations, field carcinogenesis, and cancer as an evolutionary process. Each of these topics provides novel insights and concepts on various aspects of the nature of colorectal cancer, offering new opportunities for the management of a major source of cancer incidence and mortality. Provides information on the timely nature of the included topics, which represent the most current concepts and approaches in cancer research Offers outstanding and original reviews on colorectal cancer research Provides the authority and expertise of the authors, all of whom are highly recognized and conducting state-of-the-art investigations in cancer, with this release focusing on colorectal cancer

Probiotics and Bioactive Carbohydrates in Colon Cancer Management

Probiotics and Bioactive Carbohydrates in Colon Cancer Management Book
Author : Maya Raman,Padma Ambalam,Mukesh Doble
Publisher : Springer
Release : 2015-10-27
ISBN : 8132225864
Language : En, Es, Fr & De

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Book Description :

This book describes the dietary habits (such as use of probiotics, synbiotics, prebiotics and dietary fiber) that could modify and reduce the risk of developing colorectal cancer (CRC). The book will be of practical and scientific use to academicians, research scholars, students, health professionals, nutritionists, etc. and could support the cause of preventing CRC by adopting smarter food habits. CRC is the third leading cause of death, in terms of both incidence and mortality, among men and women. Excess consumption of red and processed meat, roasted coffee, etc. have shown an increase in CRC, indicating that compounds formed in food containing free amino acids and sugars interact at elevated temperatures to form mutagens or carcinogens. Standard treatment options for CRC include invasive surgery and chemotherapy or radiation. Several lifestyle and dietary factors could prevent this ailment. Probiotics, prebiotics and synbiotics that are found in functional foods, health supplements and nutraceuticals and short chain fatty acids that are formed in the colon as a result of microbial fermentation of undigested bioactive carbohydrates by Bifidobacterium and Lactobacillus inhibit colonic epithelial cells and minimize inflammation, thereby exhibiting immunomodulatory effects. This book tries to address the novel unexplored benefits and mechanism of action of these functional foods.

The Gut Microbiome and Its Relationship to Colorectal Cancer

The Gut Microbiome and Its Relationship to Colorectal Cancer Book
Author : Elizabeth Shultes
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Humans are "supraorganisms" composed of human and microbial components. The microbial community, living in and on humans, along with their genome, is called the microbiome. The microbiome is essential to human health because it can play a role in the development of many diseases, including cancer. The gut microbiome contains the highest density of bacteria in the body. Changes in the composition of the gut microbiome are related to colorectal cancer, specifically through the production of metabolites that affect transcription of cancer suppressor genes. `Manipulation of the microbiome through diet and probiotics may lead to new cancer therapies.

The Human Microbiota and Chronic Disease

The Human Microbiota and Chronic Disease Book
Author : Luigi Nibali,Brian Henderson
Publisher : John Wiley & Sons
Release : 2016-09-26
ISBN : 1118982878
Language : En, Es, Fr & De

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Book Description :

Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease. The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states. Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section. The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position. Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition Explores the relationship humans have with their microbiota, and its significance in human health and disease Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.

Theranostics Approaches to Gastric and Colon Cancer

Theranostics Approaches to Gastric and Colon Cancer Book
Author : Ganji Seeta Rama Raju,L.V.K.S. Bhaskar
Publisher : Springer Nature
Release : 2020-03-04
ISBN : 9811520178
Language : En, Es, Fr & De

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Book Description :

This book highlights the importance of understanding gastric and colon cancer metabolism in guiding diagnosis and drug discovery. It summarizes the correlation between adiponectin and matrix metalloproteinase with colorectal cancer. The book also evaluates the divergent role of hypoxia-inducible factor 1 in colorectal cancer growth and metastasis. After discussing the role of genetic polymorphisms in alcohol metabolizing enzymes and EPHX1 with the onset of colorectal cancer, it reviews the molecular mechanisms of chemoresistance in gastric cancer and novel therapeutic strategies to reverse the chemoresistance of tumors. In addition, the book explores the theranostic role of nanoparticles and therapeutic potential of phytochemicals with regard to colorectal cancer. Given its scope, the book offers a valuable guide for oncologists, academic researchers, pharmaceuticals practitioners, and students who are involved in research and treatment of cancer.

Netter s Gastroenterology

Netter s Gastroenterology Book
Author : Martin H. Floch
Publisher : ICON
Release : 2005
ISBN : 9781929007134
Language : En, Es, Fr & De

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Book Description :

This comprehensive volume covers major gastrointestinal diseases and conditions, presenting key information on etiology, clinical presentation, differential diagnosis, management and therapy using a consistent, quick-reference format and 300 classic Netter illustrations. Other top medical illustrators have contributed new illustrations--working in the Netter style--and have updated others where appropriate.

Advancing the Science of Cancer in Latinos

Advancing the Science of Cancer in Latinos Book
Author : Amelie G. Ramirez,Edward J. Trapido
Publisher : Springer Nature
Release : 2019-11-21
ISBN : 303029286X
Language : En, Es, Fr & De

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Book Description :

This open access book gives an overview of the sessions, panel discussions, and outcomes of the Advancing the Science of Cancer in Latinos conference, held in February 2018 in San Antonio, Texas, USA, and hosted by the Mays Cancer Center and the Institute for Health Promotion Research at UT Health San Antonio. Latinos – the largest, youngest, and fastest-growing minority group in the United States – are expected to face a 142% rise in cancer cases in coming years. Although there has been substantial advancement in cancer prevention, screening, diagnosis, and treatment over the past few decades, addressing Latino cancer health disparities has not nearly kept pace with progress. The diverse and dynamic group of speakers and panelists brought together at the Advancing the Science of Cancer in Latinos conference provided in-depth insights as well as progress and actionable goals for Latino-focused basic science research, clinical best practices, community interventions, and what can be done by way of prevention, screening, diagnosis, and treatment of cancer in Latinos. These insights have been translated into the chapters included in this compendium; the chapters summarize the presentations and include current knowledge in the specific topic areas, identified gaps, and top priority areas for future cancer research in Latinos. Topics included among the chapters: Colorectal cancer disparities in Latinos: Genes vs. EnvironmentBreast cancer risk and mortality in women of Latin American originDifferential cancer risk in Latinos: The role of dietOvercoming barriers for Latinos on cancer clinical trialsEs tiempo: Engaging Latinas in cervical cancer researchEmerging policies in U.S. health care Advancing the Science of Cancer in Latinos proves to be an indispensable resource offering key insights into actionable targets for basic science research, suggestions for clinical best practices and community interventions, and novel strategies and advocacy opportunities to reduce health disparities in Latino communities. It will find an engaged audience among researchers, academics, physicians and other healthcare professionals, patient advocates, students, and others with an interest in the broad field of Latino cancer.

Study of Gut Microbiome and Metabolomics Profiling in Colorectal Cancer Patients

Study of Gut Microbiome and Metabolomics Profiling in Colorectal Cancer Patients Book
Author : Lucky Poh Wah Goh
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Study of Gut Microbiome and Metabolomics Profiling in Colorectal Cancer Patients book written by Lucky Poh Wah Goh, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Colorectal Cancer Screening

Colorectal Cancer Screening Book
Author : Joseph Anderson, MD,Charles Kahi, MD
Publisher : Springer Science & Business Media
Release : 2011-04-23
ISBN : 1607613980
Language : En, Es, Fr & De

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Book Description :

Colorectal Cancer Screening provides a complete overview of colorectal cancer screening, from epidemiology and molecular abnormalities, to the latest screening techniques such as stool DNA and FIT, Computerized Tomography (CT) Colonography, High Definition Colonoscopes and Narrow Band Imaging. As the text is devoted entirely to CRC screening, it features many facts, principles, guidelines and figures related to screening in an easy access format. This volume provides a complete guide to colorectal cancer screening which will be informative to the subspecialist as well as the primary care practitioner. It represents the only text that provides this up to date information about a subject that is continually changing. For the primary practitioner, information on the guidelines for screening as well as increasing patient participation is presentedd. For the subspecialist, information regarding the latest imaging techniques as well as flat adenomas and chromoendoscopy are covered. The section on the molecular changes in CRC will appeal to both groups. The text includes up to date information about colorectal screening that encompasses the entire spectrum of the topic and features photographs of polyps as well as diagrams of the morphology of polyps as well as photographs of CT colonography images. Algorithms are presented for all the suggested guidelines. Chapters are devoted to patient participation in screening and risk factors as well as new imaging technology. This useful volume explains the rationale behind screening for CRC. In addition, it covers the different screening options as well as the performance characteristics, when available in the literature, for each test. This volume will be used by the sub specialists who perform screening tests as well as primary care practitioners who refer patients to be screened for colorectal cancer.

Probiotic Research in Therapeutics

Probiotic Research in Therapeutics Book
Author : Parneet Kaur Deol
Publisher : Springer Nature
Release : 2020-11-13
ISBN : 9811582149
Language : En, Es, Fr & De

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Book Description :

The volume sheds new light on role of gut dysbiosis in cancer and immunological diseases and their clinical manifestations. Contributions in the volume discuss about the gut microbiota as a therapeutic target and the role of probiotics in its management. The volume explores application of probiotics in the treatment of various cancers viz. colorectal, gastric, lung, and breast cancer and immunological diseases. The volume comprises of chapters from expert contributors organized into various important themes which include, introduction, relationship between gut microbiota and disease condition, mechanisms involved, clinical and in vivo status, conclusion and future directions. This is a highly informative and carefully presented book, providing recent and innovative insight for scholars and researchers with an interest in probiotics and its applications in cancer and immunological diseases.

Characterization and Manipulation of the Colonic Microbiome in a Mouse Model of Colon Cancer

Characterization and Manipulation of the Colonic Microbiome in a Mouse Model of Colon Cancer Book
Author : Anonim
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the United States. The development of CRC is thought to be influenced by microbial populations that normally colonize the local intestinal environment, known as the colonic microbiota. Several studies have identified taxonomic shifts associated with the development of CRC. These shifts are thought to induce or result from dysbiosis, an imbalance of the microbiota in the intestine. Studies of the genetic material of the microbiota, known as the microbiome, have yielded significant insights into these populations in humans but are limited by environmental variability and microbiome differences between individuals. Colon cancer mouse models were instrumental identifying the colonic polyp-microbiota association and have the potential to minimize microbiome variability. Despite this, the microbiome has yet to be fully described in these models. In the following thesis, I have described the colonic microbiomes of a Cre-lox mouse model in two experiments: first by identifying shifts in polyp-associated microbiomes, and second, describing the effect of the therapeutic VAX-IP minicells on the colonic microbiome in polyp bearing mice. Polyp-associated microbiomes displayed several taxonomic shifts from controls including the overrepresentation of the potentially pathogenic group Enterococcacae (p = 0.01) and a reduction in the phylum Actinobacteria (p