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Cns Regeneration

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CNS Regeneration

CNS Regeneration Book
Author : Jeffrey Kordower,Mark H. Tuszynski
Publisher : Elsevier
Release : 2011-04-28
ISBN : 9780080556987
Language : En, Es, Fr & De

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Book Description :

This second edition of CNS Regeneration updates the burgeoning field of regeneration in the Central Nervous System (CNS) from molecular, systems, and disease-based perspective. While the book covers numerous areas in detail, special emphasis is given to discussions of movement disorders such as Parkinson’s disease, Alzheimer’s disease, and spinal cord injury. Incorporates information gained from cutting-edge photomicroscopy techniques Includes current information on clinical trials Presents chapters on stem cells and other novel treatments for diseases of the CNS

Opportunities and Challenges of the Therapies Targeting CNS Regeneration

Opportunities and Challenges of the Therapies Targeting CNS Regeneration Book
Author : H.D. Perez,B. Mitrovic,A. Baron Van Evercooren
Publisher : Springer Science & Business Media
Release : 2007-01-19
ISBN : 3540276262
Language : En, Es, Fr & De

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Book Description :

The therapeutic options for the treatment of Multiple Sclerosis (MS) and other neurodegenerative and traumatic diseases such as spinal cord injury, Alzheimer's, Parkinson's disease, etc. have experienced enormous progress over recent years. Despite these encouraging developments, available therapies are only partially effective, and the ultimate goal is still far from being attained. Improved understanding of the cellular and molecular mechanisms of the pathogenesis of neurodegeneration and demyelination has led to a variety of new therapeutic targets and approaches. In addition to modulation of the inflammatory process (MS) and classical neuroprotection (stroke, AD), therapeutic approaches focusing on active remyelinization and neuronal regeneration have become increasingly important. Based on current concepts, this book summarizes new therapeutic approaches.

Axonal Regeneration in the Mammalian Central Nervous System

Axonal Regeneration in the Mammalian Central Nervous System Book
Author : Dorothy E. Oorschot,David G. Jones
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642751083
Language : En, Es, Fr & De

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Book Description :

This state-of-the-art review links the experimental data into a cohesive and critical account of CNS regeneration. Research findings are discussed in terms of their relevance to one (or more) of thirteen hypotheses concerned with regeneration in the mammalian CNS. Research findings reviewed include: regeneration in developing mammals and in submammalian vertebrates, the use of transplants and/or pharmacological treatments, in vitro studies on neurotrophic and neurite promoting factors and their potential relevance to CNS regeneration in vivo, and in vitro studies on the types of glial cells that may be responsible for enhancing or suppressing axonal re-growth.

Identification of Novel Genes Critical for CNS Regeneration in Lymnaea Stagnalis

Identification of Novel Genes Critical for CNS Regeneration in Lymnaea Stagnalis Book
Author : Mila Aleksic
Publisher : Unknown
Release : 2011
ISBN : 9780494764077
Language : En, Es, Fr & De

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Book Description :

Neuronal regeneration in the mammalian central nervous system (CNS) is severely compromised due to the presence of extrinsic inhibitory signals and a reduced intrinsic regenerative capacity. Understanding the cellular and molecular processes underlying injury and regeneration in the CNS is necessary for the development of effective therapeutic strategies. Lymnaea stagnalis , a freshwater pond snail, has proven to be a powerful model for studying the fundamental mechanisms underlying neurite outgrowth and regeneration. In this study I designed the first custom L. stagnalis microarray gene chip and carried out microarray analysis to profile gene expression changes following CNS injury. From a pool of significantly regulated genes, I provided the first evidence that C/EBP, a transcription factor, plays an integral role in regeneration by maintaining the viability of the distal neurite. We also proposed a novel signaling network and demonstrated that BCL 7 regulates neurite regeneration, an effect that may be mediated through Ca2+-dependent growth cone formation.

Handbook of Innovations in Central Nervous System Regenerative Medicine

Handbook of Innovations in Central Nervous System Regenerative Medicine Book
Author : António Salgado
Publisher : Elsevier
Release : 2020-06-10
ISBN : 0128180854
Language : En, Es, Fr & De

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Book Description :

Handbook of Innovations in CNS Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials and the steps needed to follow this path. Areas such as cell transplantation approaches, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies are key in regenerative medicine are covered in the book, along with regulatory and ethical issues. Describes the basic biology and anatomy of the CNS and how injury and disease affect its balance Discusses the limitations of present therapies used in the clinics Introduces the recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies, and enabling technologies Presents successful cases of translation of basic research to first-in-human trials, along with the steps needed to follow this path

Neural Transplantation CNS Neuronal Injury and Regeneration

Neural Transplantation  CNS Neuronal Injury  and Regeneration Book
Author : Joe Marwah,Herman Teitelbaum,Kedar N. Prasad
Publisher : CRC Press
Release : 1994-02-23
ISBN : 9780849386831
Language : En, Es, Fr & De

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Book Description :

This unique reference presents studies from leading laboratories that are studying the effects of CNS transplants on neuronal plasticity and recovery of function after CNS injury. Topics covered include tropic influences, reinnervation patterns, and prevention of cell death that range from pre-clinical models of Parkinson's disease in primates to studies of restoration of circadian rhythms in rats. Techniques of neurotransplantation are presented, including current limitations and future projections of advancement.

Neural Regeneration

Neural Regeneration Book
Author : Kwok Fai So,Xiao-Ming Xu
Publisher : Academic Press
Release : 2015-02-03
ISBN : 0128018348
Language : En, Es, Fr & De

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Book Description :

Neural Regeneration provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration, including: Neural regeneration in lower vertebrates Neural regeneration in the peripheral nervous system Neural regeneration in the central nervous system Transplantation-mediated neural regeneration Clinical and translational research on neural regeneration The contributors to this book are experts in their fields and work at distinguished institutions in the United States, Canada, Australia, and China. Nervous system injuries, including peripheral nerve injuries, brain and spinal cord injuries, and stroke affect millions of people worldwide every year. As a result of this high incidence of neurological injuries, neural regeneration and repair is becoming a rapidly growing field dedicated to the new discoveries to promote structural and functional recoveries based on neural regeneration. The ultimate goal is to translate the most optimal regenerative strategies to treatments of human nervous system injuries. This valuable reference book is useful for students, postdoctors, and basic and clinical scientists who are interested in neural regeneration research. Provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration Highly translational and clinically-relevance International authors who are leaders in their respective fields Vivid art work making the chapters easily understood

Axonal Regeneration in the Central Nervous System

Axonal Regeneration in the Central Nervous System Book
Author : Nicholas A Ingoglia,Marion Murray
Publisher : CRC Press
Release : 2000-09-29
ISBN : 9780824704100
Language : En, Es, Fr & De

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Book Description :

Summarizing a review of research into factors that regulate, stimulate, and prevent regeneration in the central nervous system (CNS), this comprehensive reference progresses further into answering and resolving neuron capacity for axon regeneration in the mammalian CNS. Axonal Regeneration in the Central Nervous System analyzes axonal regeneration, reinnervation, and functional recovery in lower vertebrates examines the correlation between developmental age and the ability to regenerate considers mammalian neuron responses at the cell body, site of injury, and in the distal nerve, including apoptic cell death, and inflammatory and glial responses to injury reviews genomic responses to axotomy with a comparative description of transcribed genes from successfully regenerating neurons and neurons incapable of regrowth discusses how growing axons may induce the expression of genes in glia/Schwann cells following axotomy and regeneration describes the use of gene therapy to deliver trophic and survival factors to injured neurons explores the hospitable environments of the peripheral nerve, olfactory ensheathing cells, and fetal cell transplants for regeneration discusses results from applications of fetal CNS tissue to human spinal cord injuries and much more!

Neural Regeneration

Neural Regeneration Book
Author : Kwok-Fai So,Xiao-Ming Xu
Publisher : Academic Press
Release : 2015-02-06
ISBN : 9780128017326
Language : En, Es, Fr & De

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Book Description :

Annotation "Provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration; Highly translational and clinically-relevance; International authors who are leaders in their respective fields; Vivid art work making the chapters easily understood. Neural Regeneration provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration, including: Neural regeneration in lower vertebrates; Neural regeneration in the peripheral nervous system; Neural regeneration in the central nervous system; Transplantation-mediated neural regeneration; Clinical and translational research on neural regeneration. The contributors to this book are experts in their fields and work at distinguished institutions in the United States, Canada, Australia, and China. Nervous system injuries, including peripheral nerve injuries, brain and spinal cord injuries, and stroke affect millions of people worldwide every year. As a result of this high incidence of neurological injuries, neural regeneration and repair is becoming a rapidly growing field dedicated to the new discoveries to promote structural and functional recoveries based on neural regeneration. The ultimate goal is to translate the most optimal regenerative strategies to treatments of human nervous system injuries. This valuable reference book is useful for students, postdoctors, and basic and clinical scientists who are interested in neural regeneration research."--Publisher's description.

CNS Regeneration Bibliography

CNS Regeneration Bibliography Book
Author : National Spinal Cord Injury Association. Research Division,R. P. Veraa
Publisher : Unknown
Release : 1982
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download CNS Regeneration Bibliography book written by National Spinal Cord Injury Association. Research Division,R. P. Veraa, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Opportunities and Challenges of the Therapies Targeting CNS Regeneration

Opportunities and Challenges of the Therapies Targeting CNS Regeneration Book
Author : H.D. Perez,B. Mitrovic,A. Baron Van Evercooren
Publisher : Springer
Release : 2009-09-02
ISBN : 9783540806042
Language : En, Es, Fr & De

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Book Description :

Download Opportunities and Challenges of the Therapies Targeting CNS Regeneration book written by H.D. Perez,B. Mitrovic,A. Baron Van Evercooren, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Identification of Regulatory Factors that Control Nervous System Form Function and Regeneration in the Planarian Schmidtea Mediterranea

Identification of Regulatory Factors that Control Nervous System Form  Function  and Regeneration in the Planarian Schmidtea Mediterranea Book
Author : Martis William Cowles
Publisher : Unknown
Release : 2014
ISBN : 9781303791307
Language : En, Es, Fr & De

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Book Description :

Neurons are born from stem cells, migrate to their final location, form synaptic connections, and terminally differentiate by a process known as neurogenesis. Although this phenomenon is observed in adult organisms across metazoans, most animals lack the ability to repair catastrophic damages to the central nervous system (CNS) caused by injury, disease or aging. By contrast, planarians have the amazing ability to regenerate all tissue types (including the CNS) from a population of pluripotent adult stem cells they maintain throughout their life, making these animals a powerful system to research stem cell-based regeneration in vivo. To investigate how adult stem cells are directed to generate new neurons during CNS regeneration, we examined the basic helix-loop-helix (bHLH) transcription factor family in planarians. Many bHLH family members regulate neurogenesis during development and are associated with nervous system diseases, yet their functions in adult stem cells and mature neurons remain unclear. We identified 44 planarian bHLH homologs, determined their tissue-specific expression in the adult animal, and examined their function using RNA interference. These analyses identified nine bHLHs expressed in stem cells and neurons that were required for CNS regeneration, including homologs of Collier/Olfactory-1/Early B-cell factor (coe), Single-minded (sim), and Hairy enhancer of split (hesl-3). Furthermore, we demonstrated that coe, sim and hesl-3 mRNA were detected in lineage-committed progenitors. Our functional screen revealed that gene silencing of coe results in CNS regeneration defects. COE genes play conserved roles in nervous system development and are associated with CNS diseases; however, the genetic programs downstream of these genes remain largely unknown. By comparing the transcriptome profiles of control and coe-deficient animals, we identified over 900 differentially expressed genes, including 397 downregulated genes enriched for CNS functions. We examined downregulated genes and identified new targets of COE in mature neurons, some of which were required for CNS regeneration. Furthermore, we found novel genes expressed in stem cell progeny that function downstream of COE and were critical for stem cell homeostasis. These findings demonstrate that COE regulates genetic programs essential for CNS homeostasis and regeneration, providing insights into how COE proteins function in the adult nervous system.

Transcriptional Regulation of CNS Regeneration

Transcriptional Regulation of CNS Regeneration Book
Author : Yashashree Joshi
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Transcriptional Regulation of CNS Regeneration book written by Yashashree Joshi, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mesenchymal Stem Cells in CNS Regeneration

Mesenchymal Stem Cells in CNS Regeneration Book
Author : Arshak R. Alexanian
Publisher : Unknown
Release : 2012
ISBN : 9789535103875
Language : En, Es, Fr & De

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Book Description :

Download Mesenchymal Stem Cells in CNS Regeneration book written by Arshak R. Alexanian, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Axonal Regeneration in the Mammalian Central Nervous System

Axonal Regeneration in the Mammalian Central Nervous System Book
Author : Dorothy E. Oorschot,David G. Jones
Publisher : Springer
Release : 2012-12-06
ISBN : 9783642751080
Language : En, Es, Fr & De

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Book Description :

This state-of-the-art review links the experimental data into a cohesive and critical account of CNS regeneration. Research findings are discussed in terms of their relevance to one (or more) of thirteen hypotheses concerned with regeneration in the mammalian CNS. Research findings reviewed include: regeneration in developing mammals and in submammalian vertebrates, the use of transplants and/or pharmacological treatments, in vitro studies on neurotrophic and neurite promoting factors and their potential relevance to CNS regeneration in vivo, and in vitro studies on the types of glial cells that may be responsible for enhancing or suppressing axonal re-growth.

The Role of Microenvironment in Axonal Regeneration

The Role of Microenvironment in Axonal Regeneration Book
Author : Christine C. Stichel-Gunkel
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642607810
Language : En, Es, Fr & De

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Book Description :

Since the pioneering studies of Ramon y Cajal the inability of lesioned adult CNS axons to regenerate has been well established. During the past years advancements in molecular, cellular and biochemical knowledge have provided new insights into the extrinsic mechanims underlying regeneration failure. The rapid progress in this field has already led to the development of new concepts for therapeutic manipulations. This book provides a comprehensive overview of structural and molecular changes induced by an invasive CNS lesion and their involvements in regeneration processes. Moreover, it demonstrates the strong growth-promoting actitivies of implanted glial cells. The data is discussed in relation to current knowledge on the mechanisms of axonal degeneration and regeneration and in terms of their relevance for the development of novel therapeutic strategies.

CNS Regeneration Bibliography

CNS Regeneration Bibliography Book
Author : National Paraplegia Foundation
Publisher : Unknown
Release : 1975
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download CNS Regeneration Bibliography book written by National Paraplegia Foundation, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

CNS Regeneration Bibliography

CNS Regeneration Bibliography Book
Author : National Paraplegia Foundation. National Research Office
Publisher : Unknown
Release : 1975
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download CNS Regeneration Bibliography book written by National Paraplegia Foundation. National Research Office, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

MOLECULAR BASIS FOR REGENERATI

MOLECULAR BASIS FOR REGENERATI Book
Author : 吳達方,Tat-Fong Ng
Publisher : Open Dissertation Press
Release : 2017-01-27
ISBN : 9781374757127
Language : En, Es, Fr & De

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Book Description :

This dissertation, "Molecular Basis for Regeneration of CNS: a Possible Regulatory Role of Growth Associated Protein-43" by 吳達方, Tat-fong, Ng, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b3123521 Subjects: Central nervous system - Regeneration Nerves - Growth Nerve tissue protein

Neurotrophins Regulate the Functions of Microglia in CNS Regeneration

Neurotrophins Regulate the Functions of Microglia in CNS Regeneration Book
Author : Jianmin Zhang
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Neurotrophins Regulate the Functions of Microglia in CNS Regeneration book written by Jianmin Zhang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.