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CNS Regeneration

CNS Regeneration Book
Author : Jeffrey Kordower,Mark H. Tuszynski
Publisher : Elsevier
Release : 2011-04-28
ISBN : 9780080556987
Language : En, Es, Fr & De

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Book Description :

This second edition of CNS Regeneration updates the burgeoning field of regeneration in the Central Nervous System (CNS) from molecular, systems, and disease-based perspective. While the book covers numerous areas in detail, special emphasis is given to discussions of movement disorders such as Parkinson’s disease, Alzheimer’s disease, and spinal cord injury. Incorporates information gained from cutting-edge photomicroscopy techniques Includes current information on clinical trials Presents chapters on stem cells and other novel treatments for diseases of the CNS

Opportunities and Challenges of the Therapies Targeting CNS Regeneration

Opportunities and Challenges of the Therapies Targeting CNS Regeneration Book
Author : H.D. Perez,B. Mitrovic,A. Baron Van Evercooren
Publisher : Springer Science & Business Media
Release : 2007-01-19
ISBN : 3540276262
Language : En, Es, Fr & De

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Book Description :

The therapeutic options for the treatment of Multiple Sclerosis (MS) and other neurodegenerative and traumatic diseases such as spinal cord injury, Alzheimer's, Parkinson's disease, etc. have experienced enormous progress over recent years. Despite these encouraging developments, available therapies are only partially effective, and the ultimate goal is still far from being attained. Improved understanding of the cellular and molecular mechanisms of the pathogenesis of neurodegeneration and demyelination has led to a variety of new therapeutic targets and approaches. In addition to modulation of the inflammatory process (MS) and classical neuroprotection (stroke, AD), therapeutic approaches focusing on active remyelinization and neuronal regeneration have become increasingly important. Based on current concepts, this book summarizes new therapeutic approaches.

Axonal Regeneration in the Mammalian Central Nervous System

Axonal Regeneration in the Mammalian Central Nervous System Book
Author : Dorothy E. Oorschot,David G. Jones
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642751083
Language : En, Es, Fr & De

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Book Description :

This state-of-the-art review links the experimental data into a cohesive and critical account of CNS regeneration. Research findings are discussed in terms of their relevance to one (or more) of thirteen hypotheses concerned with regeneration in the mammalian CNS. Research findings reviewed include: regeneration in developing mammals and in submammalian vertebrates, the use of transplants and/or pharmacological treatments, in vitro studies on neurotrophic and neurite promoting factors and their potential relevance to CNS regeneration in vivo, and in vitro studies on the types of glial cells that may be responsible for enhancing or suppressing axonal re-growth.

Fundamentals of Tissue Engineering and Regenerative Medicine

Fundamentals of Tissue Engineering and Regenerative Medicine Book
Author : Ulrich Meyer,Thomas Meyer,Jörg Handschel,Hans Peter Wiesmann
Publisher : Springer Science & Business Media
Release : 2009-02-11
ISBN : 3540777555
Language : En, Es, Fr & De

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Book Description :

"Fundamentals of Tissue Engineering and Regenerative Medicine" provides a complete overview of the state of the art in tissue engineering and regenerative medicine. Tissue engineering has grown tremendously during the past decade. Advances in genetic medicine and stem cell technology have significantly improved the potential to influence cell and tissue performance, and have recently expanded the field towards regenerative medicine. In recent years a number of approaches have been used routinely in daily clinical practice, others have been introduced in clinical studies, and multitudes are in the preclinical testing phase. Because of these developments, there is a need to provide comprehensive and detailed information for researchers and clinicians on this rapidly expanding field. This book offers, in a single volume, the prerequisites of a comprehensive understanding of tissue engineering and regenerative medicine. The book is conceptualized according to a didactic approach (general aspects: social, economic, and ethical considerations; basic biological aspects of regenerative medicine: stem cell medicine, biomolecules, genetic engineering; classic methods of tissue engineering: cell, tissue, organ culture; biotechnological issues: scaffolds; bioreactors, laboratory work; and an extended medical discipline oriented approach: review of clinical use in the various medical specialties). The content of the book, written in 68 chapters by the world’s leading research and clinical specialists in their discipline, represents therefore the recent intellect, experience, and state of this bio-medical field.

Neural Transplantation CNS Neuronal Injury and Regeneration

Neural Transplantation  CNS Neuronal Injury  and Regeneration Book
Author : Joe Marwah,Herman Teitelbaum,Kedar N. Prasad
Publisher : CRC Press
Release : 1994-02-23
ISBN : 9780849386831
Language : En, Es, Fr & De

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Book Description :

This unique reference presents studies from leading laboratories that are studying the effects of CNS transplants on neuronal plasticity and recovery of function after CNS injury. Topics covered include tropic influences, reinnervation patterns, and prevention of cell death that range from pre-clinical models of Parkinson's disease in primates to studies of restoration of circadian rhythms in rats. Techniques of neurotransplantation are presented, including current limitations and future projections of advancement.

Degeneration and Regeneration in the Nervous System

Degeneration and Regeneration in the Nervous System Book
Author : Norman Saunders,Katarzyna Dziegielewska
Publisher : CRC Press
Release : 2003-09-02
ISBN : 0203304489
Language : En, Es, Fr & De

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Book Description :

Degeneration and Regeneration in the Nervous System brings together an international team of contributors to produce a series of critical reviews appraising key papers in the field. The pace of research on brain and spinal cord injury quickened considerably in the last ten years and there is much that is new and important that is covered in this book. However, there is still a long way to go before our knowledge will explain fully why the central nervous system has such a limited capacity for regeneration, and before experimental solutions can be applied to the patient. With emphasis on actual and therapeutic importance of the work reviewed, Degeneration and Regeneration in the Nervous System is a useful overview for graduate students, their teachers and researchers working in this field.

Model Organisms in Spinal Cord Regeneration

Model Organisms in Spinal Cord Regeneration Book
Author : Catherina G. Becker,Thomas Becker
Publisher : John Wiley & Sons
Release : 2007-03-30
ISBN : 3527610359
Language : En, Es, Fr & De

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Book Description :

This handbook provides a comprehensive overview for students, clinicians and researchers planning to enter the field of neural regeneration, combining the latest knowledge with an understanding of all important model organisms in one handy volume. By covering the strengths and weaknesses as well as possible applications of different models it saves researchers both time and resources in their choice of the appropriate model organism. An equally valuable introduction for the novice planning to enter the field.

Immunosuppressant Analogs in Neuroprotection

Immunosuppressant Analogs in Neuroprotection Book
Author : Cesario V. Borlongan,Ole Isacson,Paul R. Sanberg
Publisher : Springer Science & Business Media
Release : 2002-11-20
ISBN : 1592593151
Language : En, Es, Fr & De

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Book Description :

An authoritative survey of the most recent scientific evidence showing how cyclosporin, FK-506, and their analogs-the neuroimmunophilins-evolved from being purely immunosuppressant "drugs" to neuroprotective "agents". The book focuses on recent preclinical evidence that demonstrates the neurotrophic/neuroprotective effects of immunosuppressants when administered alone or when combined with neural transplantation therapy in animal models of neurological disorders.

The Physiological Basis of Rehabilitation Medicine

The Physiological Basis of Rehabilitation Medicine Book
Author : John A. Downey,Stanley J. Myers,Erwin G. Gonzalez
Publisher : Butterworth-Heinemann
Release : 2013-10-22
ISBN : 1483193993
Language : En, Es, Fr & De

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Book Description :

The Physiological Basis of Rehabilitation Medicine: Second Edition presents a comprehensive examination of the management of patients with functional impairments due to disease or trauma. It discusses the distinction between disabilities and impairments per se. It addresses the method in which the human body adapts and compensates for the stress produced by physical injuries. Some of the topics covered in the book are the physiology of cerebellum and basal ganglia; description of upper and lower motor neurons; anatomy of the vascular supply to the brain; characteristics of the autonomic nervous system; structure, chemistry, and function of skeletal muscle; the receptors in muscle; and cardiopulmonary physiology. The role of muscle spindles in perception of limb position and movement is fully covered. An in-depth account of the physiology of synovial joints and articular cartilage are provided. The cellular and glandular components of the skin are completely presented. A chapter is devoted to the factors involve in wound healing. Another section focuses on the nerve conduction and neuromuscular transmission. The book can provide useful information to doctors, dermatologists, students, and researchers.

Stem Cell and Gene Based Therapy

Stem Cell and Gene Based Therapy Book
Author : Alexander Battler,Jonathan Leor
Publisher : Springer Science & Business Media
Release : 2007-06-26
ISBN : 9781846286766
Language : En, Es, Fr & De

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Book Description :

Regenerative medicine – stem cell and gene-based therapy – offers a new approach for restoring function of damaged organs and tissues. This is the first book to cover the major new aspects and field of regenerative medicine. This title is therefore a timely addition to the literature. It brings together the major approaches to regenerative medicine in one text, which ensures that techniques learnt in one discipline are disseminated across other areas of medicine.

Progress in Anatomy Vol 3

Progress in Anatomy Vol 3 Book
Author : R. J. Harrison,V. Navaratnam
Publisher : CUP Archive
Release : 1983-12-22
ISBN : 9780521249539
Language : En, Es, Fr & De

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Book Description :

Stem Cell Biology and Regenerative Medicine

Stem Cell Biology and Regenerative Medicine Book
Author : Charles Durand,Pierre Charbord
Publisher : River Publishers
Release : 2015-01-01
ISBN : 8793237073
Language : En, Es, Fr & De

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Book Description :

The study of stem cell biology is under intensive investigations. Because stem cells have the unique capability to self-renew and differentiate into one or several cell types, they play a critical role in development, tissue homeostasis and regeneration. Stem cells also constitute promising cell candidates for cell therapy. The aim of this book is to provide an accurate knowledge on stem cell biology and regenerative medicine. This book will cover many topics in the field and is based on seminars given by recognized scientists involved the international master program on stem cell biology at the University Pierre and Marie Curie (UPMC) in Paris. Content Preface. Pierre Charbord and Charles Durand. 1) General concepts 1.Stem cell concepts. Charles Durand and Pierre Charbord. 2.Transcriptional regulation in stem cells. Eric Soler and Frank Grosveld. 3.DNA repair in stem cells. Leyla Vahidi Ferdousi and Miria Ricchetti. 4. Stem cells and epigenetic regulation. Emma L. Walton and Claire Francastel. 5. Hydra and the evolution of stem cells. Alexander Klimovich, Anna Marei Böhm and Thomas C.G. Bosch. 6. Ontogeny of stem cells. Thierry Jaffredo. 7. Regeneration in anamniotic vertebrates. Dunja Knapp. 8. Computational models of spatio-temporal stem cell organization. Peter Buske and Joerg Galle. 2) Pluripotent stem cells 9. X chromosome inactivation in stem cells and development. Agnese Loda, Friedemann Loos and Joost Gribnau. 10. Molecular machinery of reprogramming. Romain Desprat, Ollivier Milhavet and Jean-Marc Lemaitre. 11. Modeling human genetic disorders using induced pluripotent stem cells. Franck Lebrin. 3) Adult stem cells 12. Developmental biology of hematopoietic stem cells : Cellular aspects. Laurent Yvernogeau, Jean-Charles Boisset and Catherine Robin. 13. Developmental biology of haematopoietic stem cells: Cell intrinsic and extrinsic regulators of their emergence. Katrin Ottersbach. 14. Biology of hematopoietic stem cells in the adult. Marie-Laure Arcangeli, Rima Haddad, Francoise Pflumio. 15. Epithelial stem cells in the skin. Romain Fontaine, Mathieu Castela and Selim Aractingi. 16. Skeletal muscle stem cells. Elisa Negroni, Maximilien Bencze, Stéphanie Duguez, Gillian Butler-Browne and Vincent Mouly. 17. Mammary stem cells. Marie-Ange Deugnier, Marisa M. Faraldo and Marina A. Glukhova. 18. Intestinal stem cells. Silvia Fre. 19. Neural stem cells. Nathalie Kubis and Martin Catala. 20. Dental stem cells. Anne Poliard. 21. Bone marrow Mesenchymal Stem Cells: from stemness to stromal property of hematopoietic support. Pierre Charbord and Bruno Delorme. 22. Retinal stem cells. Olivier Goureau, Angélique Terray, Katherine S. Matho, Sacha Reichman, and Gael Orieux. 4) Stem cell-related diseases and therapy using stem cells 23. Leukemic stem cells: what the concept brings to disease and patient management. Berent Lunden and Christine Chomienne. 24. Stem cells for cardiac repair. Philippe Menasché. 25. Stem cells for red blood cell production. Christelle Mazurier, Guillaume F Rousseau, Luc Douay and Hélène Lapillonne. 26. Prospectives for therapy with stem cells in skeletal muscular diseases. Maximilien Bencze, Elisa Negroni, Vincent Mouly and Gillian Butler-Browne. 5) Regulatory and philosophical aspects 27. Legal framework for research on Human Embryonic Stem Cells in France and in Europe. Arnaud de Guerra, Emmanuelle Prada-Bordenave 28. Stem cell epistemological issues. Lucie Laplane. 29. Future outlook. Pierre Charbord and Charles Durand.

Regeneration and Plasticity in the Mammalian Visual System

Regeneration and Plasticity in the Mammalian Visual System Book
Author : Dominic Man-Kit Lam,Garth M. Bray
Publisher : MIT Press
Release : 1992
ISBN : 9780262121699
Language : En, Es, Fr & De

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Book Description :

This fourth volume in the Retina Research Foundation Symposia Proceedings highlights several of the strategies and experimental paradigms that are currently used to exploit and amplify the regenerative capacity of the adult mammalian visual system, and reviews the exciting advances being made in understanding the molecular basis of central nervous system regeneration.Because loss of neurons or interruptions of their connective pathways in the mammalian visual system can, in contrast to certain amphibians and fish, lead to permanent loss of vision, studies of regeneration and plasticity in this system serve as valuable models for the reconstitution of other parts of the nervous system and as potential approaches to the diverse disorders that lead to visual loss.Dominic Man-Kit Lam is Director of the Center for Biotechnology and Professor of Biotechnology, Cell Biology, and Ophthalmology at Baylor College of Medicine. Garth M. Bray is Professor in the Centre for Research in Neuroscience at McGill University.Partial Contents and Contributors: I. Introduction. Harold J. Sheedo, James E. Turner. II. Cells and Molecules that Influence Neuronal Survival. Susan 0. Meakin, Eric M. Shooter, Garth M. Bray, Lamberto Maffei it al. III. Molecular Mechanisms of Axonal Regeneration. Louis F. Reichardt, Greg E. Lemke, Randall N. Pittman, Susan Spencer, Mark B. Willard, et al. IV. Retinal Responses to Injury and Transplantation. Kwok Fai So, Raymond D. Lund, Harold J. Sheedlo, Manuel P. delCerro et al. V. Plasticity of Connectivity in the Visual System. Edward G. Jones, Douglas 0. Frost, Torsten N. Wiesel, Albert J. Aquayo, et al.

Axon Growth and Regeneration

Axon Growth and Regeneration  Book
Author : N.A
Publisher : Academic Press
Release : 2012-12-31
ISBN : 0123983223
Language : En, Es, Fr & De

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Book Description :

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding Axon Growth and Regeneration. Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Glaucoma E Book

Glaucoma E Book Book
Author : Tarek M. Shaarawy,Mark B. Sherwood,Roger A. Hitchings,Jonathan G. Crowston
Publisher : Elsevier Health Sciences
Release : 2014-09-05
ISBN : 0702055417
Language : En, Es, Fr & De

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Book Description :

As the irreversible effects of glaucoma can lead to blindness, there is high demand for early diagnosis and an ongoing need for practitioners to adopt new and evolving medical and surgical treatment options to improve patient outcomes. Glaucoma, Second Edition is the most comprehensive resource in the field delivering expert guidance for the most timely and effective diagnosis and treatment of glaucoma – aimed at specialists, fellows and general ophthalmologists. More than 300 contributors from six continents provide a truly global perspective and explore new approaches in this user friendly reference which has been updated with enhanced images, more spotlights, new videos, and more. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Get all the accuracy, expertise, and dependability you could ask for from leading specialists across six continents, for expert guidance and a fresh understanding of the subject. Develop a thorough, clinically relevant understanding of all aspects of adult and pediatric glaucoma and the latest diagnostic imaging techniques including ultrasound biomicroscopy and optical coherence tomography. Broaden your surgical repertoire with the latest surgical techniques - such as trabeculectomy, gonio-surgery, combined surgeries, and implant procedures. Glean all essential, up-to-date, need-to-know information about stem cell research, gene transfer, and implants. Find answers fast thanks to a well-organized, user-friendly full-color layout. Stay at the forefront of your field with 10 brand new chapters on trending topics including: new surgical approaches such as trabectome and canoplasty; glaucoma implications in cataract and ocular surface disease; and, updates in the costs-effectiveness of medical management. Avoid pitfalls and achieve the best outcomes thanks to more than 40 brand new spotlight commentaries from key leaders providing added insight, tips and pearls of wisdom across varying hot topics and advances in the field. Refine and improve your surgical skills by watching over 50 video clips depicting the latest techniques and procedures including: new trabeculectomy methods, needling, implants, valve complications, and more. Prevent and plan for complications in advance by examining over 1,600 illustrations, photos and graphics (1,250 in color) capturing essential diagnostics techniques, imaging methods and surgical approaches. Grasp each procedure and review key steps quickly with chapter summary boxes that provide at-a-glance quick comprehension of the key take away points.

Molecular and Cellular Biology of Neuroprotection in the CNS

Molecular and Cellular Biology of Neuroprotection in the CNS Book
Author : Christian Alzheimer
Publisher : Springer Science & Business Media
Release : 2003-01-31
ISBN : 9780306474149
Language : En, Es, Fr & De

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Book Description :

Univ. of Kiel, Germany. Text provides an overview of the recent developments in neuroprotective signaling and experimental neuroprotection. Also offers a detailed look at many of the highly intertwined processes that determine the fate of CNS neurons in the face of acute or chronic insults.

Comprehensive Biomaterials

Comprehensive Biomaterials Book
Author : Paul Ducheyne,Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick
Publisher : Elsevier
Release : 2015-08-28
ISBN : 0080552943
Language : En, Es, Fr & De

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Book Description :

Comprehensive Biomaterials brings together the myriad facets of biomaterials into one, major series of six edited volumes that would cover the field of biomaterials in a major, extensive fashion: Volume 1: Metallic, Ceramic and Polymeric Biomaterials Volume 2: Biologically Inspired and Biomolecular Materials Volume 3: Methods of Analysis Volume 4: Biocompatibility, Surface Engineering, and Delivery Of Drugs, Genes and Other Molecules Volume 5: Tissue and Organ Engineering Volume 6: Biomaterials and Clinical Use Experts from around the world in hundreds of related biomaterials areas have contributed to this publication, resulting in a continuum of rich information appropriate for many audiences. The work addresses the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, and strategic insights for those entering and operational in diverse biomaterials applications, research and development, regulatory management, and commercial aspects. From the outset, the goal was to review materials in the context of medical devices and tissue properties, biocompatibility and surface analysis, tissue engineering and controlled release. It was also the intent both, to focus on material properties from the perspectives of therapeutic and diagnostic use, and to address questions relevant to state-of-the-art research endeavors. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance as well as future prospects Presents appropriate analytical methods and testing procedures in addition to potential device applications Provides strategic insights for those working on diverse application areas such as R&D, regulatory management, and commercial development

Regenerative Medicine II

Regenerative Medicine II Book
Author : Ioannis V. Yannas
Publisher : Springer Science & Business Media
Release : 2005-03-29
ISBN : 9783540228684
Language : En, Es, Fr & De

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Book Description :

Organ regeneration, once unknown in adult mammals, is at the threshold of maturity as a clinical method for restoration of organ function in humans. Several laboratories around the world are engaged in the development of new tools such as stem cells and biologically active scaffolds. Others are taking fresh looks at well-known clinical problems of replacement of a large variety of organs: Bone, skin, the spinal cord, peripheral nerves, articular cartilage, the conjunctiva, heart valves and urologic organs. Still other investigators are working out the mechanistic pathways of regeneration and the theoretical implications of growing back organs in an adult. The time has come to present a collection of these efforts from leading practitioners in the field of organ regeneration.

Neuroglia

Neuroglia Book
Author : Helmut Kettenmann,Bruce R. Ransom
Publisher : Oxford University Press
Release : 2005
ISBN : 9780195152227
Language : En, Es, Fr & De

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Book Description :

Graduate students in neuroanatomy, neurochemistry, neurophysiology, and molecular neurobiology will find the book indispensable. It is also a vital companion for researchers in these fields as well as clinicians in neurology, neurosurgery, neuropathology, neuro-oncology, physiatry, and psychiatry."--BOOK JACKET.