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Closed Loop Neuroscience

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Closed Loop Neuroscience

Closed Loop Neuroscience Book
Author : Ahmed El Hady
Publisher : Academic Press
Release : 2016-09-08
ISBN : 0128026413
Language : En, Es, Fr & De

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Book Description :

Closed Loop Neuroscience addresses the technical aspects of closed loop neurophysiology, presenting the implementation of these approaches spanning several domains of neuroscience, from cellular and network neurophysiology, through sensory and motor systems, and then clinical therapeutic devices. Although closed-loop approaches have long been a part of the neuroscientific toolbox, these techniques are only now gaining popularity in research and clinical applications. As there is not yet a comprehensive methods book addressing the topic as a whole, this volume fills that gap, presenting state-of-the-art approaches and the technical advancements that enable their application to different scientific problems in neuroscience. Presents the first volume to offer researchers a comprehensive overview of the technical realities of employing closed loop techniques in their work Offers application to in-vitro, in-vivo, and hybrid systems Contains an emphasis on the actual techniques used rather than on specific results obtained Includes exhaustive protocols and descriptions of software and hardware, making it easy for readers to implement the proposed methodologies Encompasses the clinical/neuroprosthetic aspect and how these systems can also be used to contribute to our understanding of basic neurophysiology Edited work with chapters authored by leaders in the field from around the globe – the broadest, most expert coverage available

Closed Loop Systems for Next Generation Neuroprostheses

Closed Loop Systems for Next Generation Neuroprostheses Book
Author : Timothée Levi,Paolo Bonifazi, Paolo Massobrio,Michela Chiappalone
Publisher : Frontiers Media SA
Release : 2018-04-26
ISBN : 2889454665
Language : En, Es, Fr & De

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Book Description :

Millions of people worldwide are affected by neurological disorders which disrupt the connections within the brain and between brain and body causing impairments of primary functions and paralysis. Such a number is likely to increase in the next years and current assistive technology is yet limited. A possible response to such disabilities, offered by the neuroscience community, is given by Brain-Machine Interfaces (BMIs) and neuroprostheses. The latter field of research is highly multidisciplinary, since it involves very different and disperse scientific communities, making it fundamental to create connections and to join research efforts. Indeed, the design and development of neuroprosthetic devices span/involve different research topics such as: interfacing of neural systems at different levels of architectural complexity (from in vitro neuronal ensembles to human brain), bio-artificial interfaces for stimulation (e.g. micro-stimulation, DBS: Deep Brain Stimulation) and recording (e.g. EMG: Electromyography, EEG: Electroencephalography, LFP: Local Field Potential), innovative signal processing tools for coding and decoding of neural activity, biomimetic artificial Spiking Neural Networks (SNN) and neural network modeling. In order to develop functional communication with the nervous system and to create a new generation of neuroprostheses, the study of closed-loop systems is mandatory. It has been widely recognized that closed-loop neuroprosthetic systems achieve more favorable outcomes for users then equivalent open-loop devices. Improvements in task performance, usability, and embodiment have all been reported in systems utilizing some form of feedback. The bi-directional communication between living neurons and artificial devices is the main final goal of those studies. However, closed-loop systems are still uncommon in the literature, mostly due to requirement of multidisciplinary effort. Therefore, through eBook on closed-loop systems for next-generation neuroprostheses, we encourage an active discussion among neurobiologists, electrophysiologists, bioengineers, computational neuroscientists and neuromorphic engineers. This eBook aims to facilitate this process by ordering the 25 contributions of this research in which we highlighted in three different parts: (A) Optimization of different blocks composing the closed-loop system, (B) Systems for neuromodulation based on DBS, EMG and SNN and (C) Closed-loop BMIs for rehabilitation.

Brain Machine Interface

Brain Machine Interface Book
Author : Xilin Liu,Jan Van der Spiegel
Publisher : Springer
Release : 2017-10-17
ISBN : 3319679406
Language : En, Es, Fr & De

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Book Description :

This book provides an introduction to the emerging area of “Brain-Machine Interfaces,” with emphasis on the operation and practical design aspects. The book will help both electrical & bioengineers as well as neuroscience investigators to learn about the next generation brain-machine interfaces. The comprehensive review and design analysis will be very helpful for researchers who are new to this area or interested in the study of the brain. The in-depth discussion of practical design issues especially in animal experiments will also be valuable for experienced researchers.

Towards Closed Loop Neuromodulation with Wireless Biomimetic Circuits and Systems

Towards Closed Loop Neuromodulation with Wireless Biomimetic Circuits and Systems Book
Author : Po-Min Wang
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Conventional functional electrical stimulation for neuromodulation delivers regular and periodic electrical pulses in an open-loop fashion. However, with advances in neuroscience, emerging applications require an electrical stimulation delivered in a non-conventional form. For example, electroceuticals and brain-machine interface (BMI) need a closed-loop modulation scheme such that the stimulation protocol can be dynamically adjusted in response to the subject's physiological state. Furthermore, it has been recently shown that a stimulation pattern that mimics the biological signal (i.e. biomimetic stimulation) outperforms periodic pulses in some applications including retina stimulation to regain eyesight and spinal cord stimulation to restore motor function. Despite increasing interests in closed-loop neuromodulation and biomimetic stimulation, existing implantable neuromodulation devices have limited capability in supporting those sophisticated stimulation schemes. We have developed two wireless biomimetic systems--an implantable stimulation and recording system and a biomimetic stimulation system, aiming to support closed-loop neuromodulation and biomimetic stimulation. In this dissertation, system design and circuit implementation of both systems are presented. Both systems were validated in bench-top tests and in-vivo experiments. The implantable system was used to conduct intestinal stimulation that facilitated the intestinal transit in chronic porcine experiments. The implant is an order lighter and 7.7 times smaller than commercialized GI stimulators, and the delivered electrical charge is smaller than most existing protocols, thus safer and more energy-efficient. The system was also used to conduct acute epidural stimulation in rat models and selectively activate desired muscles through targeting different motor neurons, laying the foundation for the future development of the control algorithms for closed-loop epidural stimulation. On the other hand, the biomimetic stimulation system was also validated in acute experiments using spinally transected rats. The system that delivered a protocol mimicking electromyography (EMG) signal lowered the excitation threshold of the spinal network, showing its potential of accelerating the rate of functional recovery after spinal cord injury. The development of these two biomimetic systems along with the future implementation of the closed-loop control algorithm using the in-vivo data acquired by both systems will make an implantable device that supports closed-loop biomimetic stimulation a reality.

Neuroengineering

Neuroengineering Book
Author : Daniel J. DiLorenzo,Joseph D. Bronzino
Publisher : CRC Press
Release : 2007-12-07
ISBN : 9780849381850
Language : En, Es, Fr & De

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Book Description :

Based on a foundation of science and empirical observation, engineering research and design has brought science fiction into science fact. The convergence of neuroscience and technology is facilitating the development of therapies that not long ago would have seemed unimaginable, if not impossible. With contributions from pioneers in industry, academia, and clinical medicine, Neuroengineering provides an understanding of the history, physiology and the most promising engineering technologies. The book presents clinical applications of neuromodulation and a detailed review of the science and mechanisms of action underlying deep brain stimulation. Contributions include discussions of seizure control, clinical, surgical, and technological aspects of responsive neurostimulation, and a thorough review of spinal cord stimulation for pain control. The book highlights promising technologies and applications for neural augmentation, brain and computer interfaces, and motor protheses. It concludes with coverage of the science underlying current neurostimulation techniques and new paradigm-shifting neuromodulation technologies. We are on the cusp of a technological revolution that promises to have more of an impact on human health, disease, and quality of life than any other in recent history. Its impact on medicine and society promises to be as dramatic as that of the development of antibiotics. The transition of neural engineering from basic research to intense commercialization and widespread clinical application and acceptance is just around the corner. Providing in-depth coverage of cutting-edge developments in technology and clinical practice, the book presents detailed descriptions of technologies, science, and clinical results that build a foundation for the future.

Brain Machine Interface

Brain Machine Interface Book
Author : Xilin Liu,Jan Van der Spiegel
Publisher : Springer
Release : 2018-09-01
ISBN : 9783319885148
Language : En, Es, Fr & De

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Book Description :

This book provides an introduction to the emerging area of “Brain-Machine Interfaces,” with emphasis on the operation and practical design aspects. The book will help both electrical & bioengineers as well as neuroscience investigators to learn about the next generation brain-machine interfaces. The comprehensive review and design analysis will be very helpful for researchers who are new to this area or interested in the study of the brain. The in-depth discussion of practical design issues especially in animal experiments will also be valuable for experienced researchers.

Computational Neurostimulation

Computational Neurostimulation Book
Author : Anonim
Publisher : Elsevier
Release : 2015-11-16
ISBN : 0444635475
Language : En, Es, Fr & De

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Book Description :

Computational Neurostimulation, the latest volume in the Progress in Brain Research series provides an introduction to a nascent field with contributions from leading researchers. In addition, it addresses a very timely and relevant issue which has long been known to require more treatment. Part of a well-established international series that examines major areas of basic and clinical research within neuroscience, as well as emerging subfields Provides an introduction to a nascent field with contributions from leading researchers

Recovery of Dynamics and Function in Spiking Neuralnetworks with Closed loop Control

Recovery of Dynamics and Function in Spiking Neuralnetworks with Closed loop Control Book
Author : Ioannis Vlachos,Taşkın Deniz,Ad Aertsen,Arvind Kumar
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Abstract: There is a growing interest in developing novel brain stimulation methods to control disease--related aberrant neural activity and to address basic neuroscience questions. Conventional methods for manipulating brain activity rely on open-loop approaches that usually lead to excessive stimulation and, crucially, do not restore the original computations performed by the network. Thus, they are often accompanied by undesired side-effects. Here, we introduce delayed feedback control (DFC), a conceptually simple but effective method, to control pathological oscillations in spiking neural networks (SNNs). Using mathematical analysis and numerical simulations we show that DFC can restore a wide range of aberrant network dynamics either by suppressing or enhancing synchronous irregular activity. Importantly,DFC, besides steering the system back to a healthy state, also recovers the computations performed by the underlying network. Finally, using our theory we identify the role of single neuron and synapse properties in determining the stability of the closed-loop system

Dynamic Neuroscience

Dynamic Neuroscience Book
Author : Zhe Chen,Sridevi V. Sarma
Publisher : Springer
Release : 2017-12-27
ISBN : 3319719769
Language : En, Es, Fr & De

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Book Description :

This book shows how to develop efficient quantitative methods to characterize neural data and extra information that reveals underlying dynamics and neurophysiological mechanisms. Written by active experts in the field, it contains an exchange of innovative ideas among researchers at both computational and experimental ends, as well as those at the interface. Authors discuss research challenges and new directions in emerging areas with two goals in mind: to collect recent advances in statistics, signal processing, modeling, and control methods in neuroscience; and to welcome and foster innovative or cross-disciplinary ideas along this line of research and discuss important research issues in neural data analysis. Making use of both tutorial and review materials, this book is written for neural, electrical, and biomedical engineers; computational neuroscientists; statisticians; computer scientists; and clinical engineers.

Side Effect Mitigation Methods for Closed loop Deep Brain Stimulation

Side Effect Mitigation Methods for Closed loop Deep Brain Stimulation Book
Author : Margaret C. Thompson
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Advances in deep brain stimulation, such as the development of closed-loop algorithms that sense and respond to patient symptoms in real time, promise to deliver therapy that is increasingly tailored to individual patients and their day-to-day variations in symptoms. However, while the potential for better side-effect management through closed-loop deep brain stimulation (CLDBS) has been recognized, the majority of CLDBS research to date has focused only on tradeoffs between power savings and symptom reduction with little consideration for side-effects. Given that side-effects, when present, can be inconvenient for some patients and have a severe impact on well-being for others, developing a better understanding of side-effects and creating CLDBS algorithms for side-effect mitigation could greatly improve outcomes for recipients of DBS therapy. This dissertation describes research investigating two novel approaches to side effect mitigation for individuals with neurological movement disorders: first, the identification and use of involuntary neural biomarkers of side-effects as triggers for changes in stimulation; and second, the use of voluntarily-controlled, brain-computer interface (BCI) methods to give patients the ability to consciously adjust stimulation parameters to balance trade-offs (such as those between symptom reduction and side effect mitigation). These approaches were designed and tested with two groups of human subjects: Parkinson’s disease patients at University of California, San Francisco and essential tremor patients at University of Washington. In addition to piloting new approaches to CLDBS therapy, this research demonstrates the importance of such systems as investigative tools to better understand the underlying neuroscience of these disorders. In addition to presenting contributions to side-effect mitigation in CLDBS, this dissertation explores certain neuroethical challenges that arose within the aforementioned neural engineering research. The concept of BCI illiteracy is critiqued as a framework that is commonly used in BCI research that is intellectually and ethically problematic. Lastly, the structure and function of an ongoing ethics collaboration conducted during this research is described and recommendations are compiled for future neural engineering research teams who are considering ways to apply ethics considerations to their research projects. This research in neuroethics provides new insight into existing neural engineering topics such as BCI illiteracy; it also has potential to enable future science and engineering researchers to better approach neuroethics in their own areas of expertise.

Neural Computation in Embodied Closed Loop Systems for the Generation of Complex Behavior From Biology to Technology

Neural Computation in Embodied Closed Loop Systems for the Generation of Complex Behavior  From Biology to Technology Book
Author : Poramate Manoonpong,Christian Tetzlaff
Publisher : Frontiers Media SA
Release : 2018-10-11
ISBN : 2889456056
Language : En, Es, Fr & De

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Book Description :

How can neural and morphological computations be effectively combined and realized in embodied closed-loop systems (e.g., robots) such that they can become more like living creatures in their level of performance? Understanding this will lead to new technologies and a variety of applications. To tackle this research question, here, we bring together experts from different fields (including Biology, Computational Neuroscience, Robotics, and Artificial Intelligence) to share their recent findings and ideas and to update our research community. This eBook collects 17 cutting edge research articles, covering neural and morphological computations as well as the transfer of results to real world applications, like prosthesis and orthosis control and neuromorphic hardware implementation.

Closing the Loop Around Neural Systems

Closing the Loop Around Neural Systems Book
Author : Steve M Potter,Eberhard E Fetz,Ahmed El Hady
Publisher : Frontiers Media SA
Release : 2014-12-03
ISBN : 288919356X
Language : En, Es, Fr & De

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Book Description :

Closed-loop neurophysiology has been accelerated by recent software and hardware developments and by the emergence of novel tools to control neuronal activity with spatial and temporal precision, in which stimuli are delivered in real time based on recordings or behavior. Real-time stimulation feedback enables a wide range of innovative studies of information processing and plasticity in neuronal networks. This Research Topic e-Book comprises 16 Original Research Articles, seven Methods Articles, and seven Reviews, Mini- Reviews, and Perspectives, all peer-reviewed and published in Frontiers in Neural Circuits. The contributions deal with closed loop neurophysiology experiments at a variety of levels of neural circuit complexity. Some include modeling and theoretical analyses. New enabling technologies and techniques are described. Novel work is presented from experiments in vitro, in vivo, and in humans, along with their clinical and technological implications for improving the human condition.

In Vitro Neuronal Networks

In Vitro Neuronal Networks Book
Author : Michela Chiappalone,Valentina Pasquale,Monica Frega
Publisher : Springer
Release : 2019-05-09
ISBN : 3030111350
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive overview of the incredible advances achieved in the study of in vitro neuronal networks for use in basic and applied research. These cultures of dissociated neurons offer a perfect trade-off between complex experimental models and theoretical modeling approaches giving new opportunities for experimental design but also providing new challenges in data management and interpretation. Topics include culturing methodologies, neuroengineering techniques, stem cell derived neuronal networks, techniques for measuring network activity, and recent improvements in large-scale data analysis. The book ends with a series of case studies examining potential applications of these technologies.

A Closed Loop Brain Computer Interface System

A Closed Loop Brain Computer Interface System Book
Author : Anonim
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Currently available closed-loop brain-computer interface (BCI) systems work as software tools for analysis and stimulation generator for the recorded neural activity in realtime, the main concerns with this software tools are the power consumption, area utilization, and the mobility of the system. The effective hardware implementation of the closed loop BCI system can be used in the many application in real-time neural activity analysis and feedback stimulation generation. The objective of the proposed design is to develop a feedback BCI system which enables the researchers to acquire the brain signal patterns from the 32 channels, record the action potentials. From the recorded action potentials, the system translates the data which gives information about the inter-spike samples and the channel number. This translated data then in-line with monitor screen to probe the visual cortex. The presented work uses various communication protocols such as AXI, TCP/IP, and SPI to interact with different blocks of the design. The prime focus of this thesis is to develop the ARM to FPGA interface and spike detection algorithm which is implemented on the programming logic using Verilog HDL. Along with, generation of the visual stimulation on host computer in real-time. The developed programming logic then incorporated with processing system to achieve the proposed system architecture. The functional performance of the closed loop BCI system is validated using two different set of input data samples. This work can find application in helping the neuroscience researchers to observe neuronal activity in the visual cortex by changing the visual stimulation patterns according to the detected action potential

Deep Brain Stimulation

Deep Brain Stimulation Book
Author : William S. Anderson,The Society for Innovative Neuroscience in Neurosurgery
Publisher : Thieme
Release : 2019-05-10
ISBN : 1626237980
Language : En, Es, Fr & De

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Book Description :

The one-stop resource on deep brain stimulation for functional neurosurgeons! Deep brain stimulation (DBS) is used to modulate dysfunctional circuits in the brain with stimulation pulses applied to specific target areas of the brain. Globally, DBS procedures have been most commonly performed for Parkinson's disease and essential tremor, but there are now new and growing research efforts studying DBS for psychiatric disorders and epilepsy. Deep Brain Stimulation: Techniques and Practices written by the Society for Innovative Neuroscience in Neurosurgery along with Dr. William S. Anderson and distinguished experts presents the latest DBS approaches. The book begins with a history of DBS, general frame-based techniques, patient selection primarily for movement disorders, multidisciplinary collaboration, and ethical considerations. Subsequent chapters detail diverse technologies and disease-specific treatment for Parkinson's disease, essential tremor, dystonia, OCD, epilepsy, major depression, Tourette syndrome, emerging psychiatric indications, and pediatric applications. Key highlights Lead placement techniques utilizing currently available customized platforms and robotics Microelectrode recording and image-based direct targeting with MRI and CT to enhance lead placement Lesioning methods including radiofrequency, and MR-guided focused ultrasound Discussion of recent innovations in tractography to delineate white matter tracts in the brain and closed loop stimulation DBS has helped thousands of patients with intractable conditions, allowing for a programmable therapy with durable treatment effect. This remarkable guide provides the essentials for functional neurosurgeons to pursue intraoperative research opportunities in this growing subspecialty and incorporate DBS into clinical practice.

A Modular Neural Interface for Massively Parallel Recording and Control

A Modular Neural Interface for Massively Parallel Recording and Control Book
Author : Christian T. Wentz
Publisher : Unknown
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The closed-loop Brain-Machine Interface (BMI) has long been a dream for clinicians and neuroscience researchers alike - that is, the ability to extract meaningful information from the brain, perform computation on this information, and selectively perturb neural dynamics in the brain for therapeutic benefit to the patient. Such systems have immediate application to treatment of paralysis, epilepsy and the amputated, and the potential for treatment of higher order cognitive dysfunction. Despite the promise of the BMI concept, the technology for bidirectional communication with the brain at sufficiently large scale to be truly therapeutically useful is lacking. Current state-of-the-art neuromodulation systems deliver open loop, 16-channel patterned electrical stimulation incapable of precisely targeting small numbers of neurons. Large-scale neural recording systems are limited to 16-128 electrodes, at the cost of several thousand dollars per channel. The ability to record from the awake behaving animal - let alone precisely modulate neural network dynamics in closed-loop fashion- presents a substantial challenge today. In this thesis, I present decoupled design solutions for three critical subcomponents of the closed-loop BMI - (i) a highly miniature, wirelessly powered and wirelessly controlled implantable optogenetic neuromodulation system capable of selective neural network control with single neural subtype- and millisecond-timescale precision, (ii) a prototype, highly parallel and scalable bio-potential recording system for simultaneous monitoring of many thousands of electrodes, and (iii) a space- and energy-efficient battery charger for biomedical applications. In aggregate, these systems overcome many of the fundamental architectural problems seen in the research and clinical environment today, potentially enabling a new class of neuromodulation system capable of treatment of higher-order cognitive dysfunction. In the research setting, these systems may be scaled to enable whole-brain recording, potentially yielding insights into large-scale neural network dynamics underlying disease and cognition.

Reviews of Neuroscience

Reviews of Neuroscience Book
Author : Seymour Ehrenpreis,Irwin J. Kopin
Publisher : Unknown
Release : 1978
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Reviews of Neuroscience book written by Seymour Ehrenpreis,Irwin J. Kopin, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Effects of Game and Game like Training on Neurocognitive Plasticity

Effects of Game and Game like Training on Neurocognitive Plasticity Book
Author : Guido P. H. Band,Chandramallika Basak,Heleen A. Slagter,Michelle W. Voss
Publisher : Frontiers Media SA
Release : 2016-05-17
ISBN : 2889198405
Language : En, Es, Fr & De

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Book Description :

Cognitive training is not always effective. This is also the case for the form of cognitive training that this Research Topic focuses on: prolonged performance on game-like cognitive tasks. The ultimate goal of this cognitive training is to improve ecologically-valid target functions. For example, cognitive training should help children with ADHD to stay focused at school, or help older adults to manage the complexity of daily life. However, so far this goal has proven too ambitious. Transfer from trained to non-trained tasks is not even guaranteed in a laboratory, so there is a strong need for understanding how, when and for how long cognitive training has effect. Which cognitive functions are amenable to game training, for whom, and how? Are there mediating factors for success, such as motivation, attention, or age? Are the improvements real, or can they be attributed to nonspecific factors, such as outcome expectancy or demand characteristics? Are there better strategies to improve cognitive functions through game training? This Research Topic of Frontiers in Human Neuroscience charts current insights in the determinants of success of game training.

International Journal of Neuroscience

International Journal of Neuroscience Book
Author : Anonim
Publisher : Unknown
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download International Journal of Neuroscience book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neural Computation Neural Devices and Neural Prosthesis

Neural Computation  Neural Devices  and Neural Prosthesis Book
Author : Zhi Yang
Publisher : Springer Science & Business Media
Release : 2014-04-15
ISBN : 1461481511
Language : En, Es, Fr & De

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Book Description :

In the past decades, interdisciplinary investigations overlapping biology, medicine, information science, and engineering have formed a very exciting and active field that attracts scientists, medical doctors, and engineers with knowledge in different domains. A few examples of such investigations include neural prosthetic implants that aim to improve the quality of life for patients suffering from neurologic disease and injury; brain machine interfaces that sense, analyze, and translate electrical signals from the brain to build closed-loop, biofeedback systems; and fundamental studies of intelligence, cognitive functions, and psychological behaviors correlated to their neurological basis. Although this interdisciplinary area is still in its infancy, it can potentially create some of the most significant impact: treating diseases that are considered untreatable, interpretation and communication of neuron ensembles, or even a revolutionary perception and understanding of life different from philosophical or immaterial approaches. Fortunately, several academic societies recognize the value and impact of this growing field, firmly supporting related research. Such support will drive a booming future in the next twenty or thirty years. Research in this area is frequently project-driven, and the generated knowledge has been scattered in different fields of neuroscience, computation, material and technology, circuits and system, clinical reports, and psychology—the scope considerably across the boundary of traditionally defined disciplines. Neural Computation, Neural Devices, and Neural Prosthesis is intended to assemble such knowledge, from there suggesting a systematic approach guiding future educational and research activities. The targeted audience includes both students and researchers.