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Clinical Trial Design Challenges In Mood Disorders

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Clinical Trial Design Challenges in Mood Disorders

Clinical Trial Design Challenges in Mood Disorders Book
Author : Mauricio Tohen,Charles Bowden,Andrew A. Nierenberg,John Geddes
Publisher : Academic Press
Release : 2015-01-24
ISBN : 0124051766
Language : En, Es, Fr & De

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Book Description :

Poor clinical trial designs result in failed studies wasting research funds and limiting the advancement of cures for disorders. Clinical Trial Design Challenges in Mood Disorders outlines classic problems researchers face in designing clinical trials and discusses how best to address them for the most definitive and generalizable results. Traditional trial designs are included as well as novel analytic techniques. The book examines information on high placebo response, the generalizability of studies conducted in the developing world, the duration of maintenance studies, and the application of findings into clinical practice. With representation from contributors throughout the world and from academia, industry, regulatory agencies, and advocacy groups, this book will contribute toward improved clinical trial design and valid, precise, and reliable answers about what works better and faster for patients. Summarizes common trial design problems and their solutions Encompasses funding, subject selection, regulatory issues and more Identifies best practices for definitive and generalizable results Includes traditional trial designs and novel analytic techniques Represents academia, industry, regulatory agencies, and advocacy groups

Behavioral Clinical Trials for Chronic Diseases

Behavioral Clinical Trials for Chronic Diseases Book
Author : Lynda H. Powell
Publisher : Springer Nature
Release : 2021-10-21
ISBN : 3030393305
Language : En, Es, Fr & De

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Book Description :

Download Behavioral Clinical Trials for Chronic Diseases book written by Lynda H. Powell, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Medical Basis of Psychiatry

The Medical Basis of Psychiatry Book
Author : S. Hossein Fatemi,Paula J. Clayton
Publisher : Springer
Release : 2016-03-17
ISBN : 1493925288
Language : En, Es, Fr & De

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Book Description :

Four years have passed since the last edition (3rd) of this book was published. In the intervening years, several reviews of this book have provided highly encouraging remarks about the value of this book in transmitting information on classification and treatment of psychiatric disorders to the audience. We are proposing to revise all chapters with an eye on accuracy and ease of use, and this is an especially timely endeavor with the upcoming publication of the Diagnostic and Statistical Manual V. All the appropriate new information on biology, etiology, diagnosis and treatment of psychiatric disorders will be added to the current proposed edition. It is our goal to recruit the same authors (if possible) who contributed to the previous edition. While all chapters will be updated (see TOC), those marked by asterisks will be the most likely to undergo more revision. Psychiatry has emerged as a burgeoning scientific field with major advances in etiology and treatment of several disorders. Just as there was excitement in the anatomic advances that took place a hundred years ago when Emil Kraepelin and his collaborators took on the enormous task of classification of psychiatric disorders based on rational scientific thinking, new advances in genetics, biochemistry, neuroanatomy and pharmacotherapy of mental disorders have brought us even closer to a better understanding of complex disorders like schizophrenia, bipolar disorder, depression and even autism. The major goal of the previous edition of this classic book was to update the busy clinician, psychiatric resident and medical student with the most up-to-date information on etiology, diagnosis and treatment of psychiatric disorders. This goal remains the focus of the fourth edition of this book. In this updated and expanded edition, the reader will be provided with the most contemporary information and literature supported by a close survey of the field. This new edition of this classic title, with its focus on biologic and medical aspects of psychiatry, will continue to be of significant help to all interested in the scientific practice of psychiatry.

Understanding Research for Nursing Students

Understanding Research for Nursing Students Book
Author : Peter Ellis
Publisher : Learning Matters
Release : 2018-10-29
ISBN : 1526459698
Language : En, Es, Fr & De

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Book Description :

If you’re learning about research for the first time, or grappling with an essay or final year project, this is the nursing research book you’re looking for. Using plain language and case studies that relate research directly to every-day nursing situations, the author guides you through the central concepts you need to know to truly understand research in nursing. Key features Each chapter is linked to the new NMC standards of proficiency for registered nurses Seven concise chapters that quickly answer the most common questions about research Activities, scenarios and case studies bring the theory to life and show why research is so important to nursing Nine podcasts to bring topics from the book to life

Clinical Trials in Older Adults

Clinical Trials in Older Adults Book
Author : Antonio Cherubini,Roberto Bernabei,Luigi Ferrucci,Niccolò Marchionni,Stephanie Studenski,Bruno Vellas
Publisher : John Wiley & Sons
Release : 2016-01-13
ISBN : 1118323475
Language : En, Es, Fr & De

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Book Description :

Clinical Trials in Older Adults is the first book to consider the methodological issues underlying the evaluation of new treatments in older people. Provides information on the methodology, monitoring and regulations for those planning to conduct a clinical trials involving older adults Contains examples of ongoing trials involving older adults, and presents the main characteristics of many recently published Depicts how the issues regarding older adults in clinical trials could be properly addressed with the appropriate study design and conduct Identifies key issues in performing clinical trials in older patients with common geriatric conditions, i.e. Alzheimer’s dementia, depression, low muscle mass, cancer

Healthy Aging

Healthy Aging Book
Author : Patrick P. Coll
Publisher : Springer
Release : 2019-03-29
ISBN : 3030062007
Language : En, Es, Fr & De

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Book Description :

This book weaves all of these factors together to engage in and promote medical, biomedical and psychosocial interventions, including lifestyle changes, for healthier aging outcomes. The text begins with an introduction to age-related changes that increase in disease and disability commonly associated with old age. Written by experts in healthy aging, the text approaches the principles of disease and disability prevention via specific health issues. Each chapter highlights the challenge of not just increasing life expectancy but also deceasing disease burden and disability in old age. The text then shifts into the whole-person implications for clinicians working with older patients, including the social and cultural considerations that are necessary for improved outcomes as Baby Boomers age and healthcare systems worldwide adjust. Healthy Aging is an important resource for those working with older patients, including geriatricians, family medicine physicians, nurses, gerontologists, students, public health administrators, and all other medical professionals.

The Ethical Challenges of Emerging Medical Technologies

The Ethical Challenges of Emerging Medical Technologies Book
Author : Arthur L. Caplan,Brendan Parent
Publisher : Routledge
Release : 2020-09-10
ISBN : 1000151999
Language : En, Es, Fr & De

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Book Description :

This collection of essays emphasizes society’s increasingly responsible engagement with ethical challenges in emerging medical technology. Expansion of technological capacity and attention to patient safety have long been integral to improving healthcare delivery but only relatively recently have concepts like respect, distributive justice, privacy, and autonomy gained some power to shape the development, use, and refinement of medical tools and techniques. Medical ethics goes beyond making better medicine to thinking about how to make the field of medicine better. These essays showcase several ways in which modern ethical thinking is improving safety, efficacy and efficiency of medical technology, increasing access to medical care, and empowering patients to choose care that comports with their desires and beliefs. Included are complimentary ethical approaches as well as compelling counter-arguments. Together, the articles demonstrate how improving the quality of medical technology relies on every stakeholder -- not just medical researchers and scientists -- to assess each given technology’s strengths and pitfalls. This collection also portends one of the next major issues in the ethics of medical technology: developing the requisite moral framework to accompany shifts toward patient-centred personalized healthcare.

Posttraumatic Stress and Substance Use Disorders

Posttraumatic Stress and Substance Use Disorders Book
Author : Anka A. Vujanovic,Sudie E. Back
Publisher : Routledge
Release : 2019-04-23
ISBN : 1315442620
Language : En, Es, Fr & De

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Book Description :

Posttraumatic Stress and Substance Use Disorders summarizes the state of the field from a biopsychosocial perspective, addressing key domains of interest to clinicians, students, instructors, and researchers. This book is a valuable resource and reference guide for multidisciplinary practitioners and scientists interested in the evidence-based assessment and treatment of posttraumatic stress and substance use disorders. Chapters written by leaders in the field cover the latest research on assessment, diagnosis, evidence-based treatments, future directions, and much more.

Cognitive Enhancement in CNS Disorders and Beyond

Cognitive Enhancement in CNS Disorders and Beyond Book
Author : Richard S. E. Keefe,Avi (Abraham) Reichenberg,Jeffrey Cummings
Publisher : Oxford University Press
Release : 2017
ISBN : 0190214406
Language : En, Es, Fr & De

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Book Description :

Cognitive Enhancement in CNS Disorders and Beyond compiles a series of educational and thought-provoking chapters from the world's leading cognitive and clinical scientists to describe the latest research on cognitive impairments in a host of pathological conditions that affect CNS functioning, what treatments are available for these impairments, and how new treatments are being tested. This volume will benefit any investigators in cognitive science and clinical research, but is also accessible to non-experts. It advances the field toward the availability of cognitive enhancing drugs and devices that will benefit those who need them most and others who may feel that these techniques can help them to thrive. There has never been a time that we knew more about cognition and never a time when cognition was more important to the functioning of human beings than right now. Psychological science and cognitive neuroscience have become the most popular endeavor of students world wide, is the focus of attention of our greatest scientific accomplishments and the emphasis of many publications in the mainstream media. Since humans depend on cognitive abilities for survival, quality of life, and productivity, improving it has never been more important. Those with impairments in key aspects of cognition suffer dearly, as they are unable to obtain and retain information, unable to make sound decisions based upon the information at hand, and unable to plan future activities. The availability of pharmacological and behavioral interventions that can improve cognitive abilities and provide impaired individuals with the social, occupational and functional quality of life that the rest of us enjoy has potential far-reaching implications. Such interventions can also benefit those who want to boost current cognitive abilities to higher levels, perhaps as a means to hone skills in providing products for others or to gain an edge on competition. There has never been a book devoted solely to describing the latest cognitive science and neuroscience on the methods for enhancing cognition in healthy and unhealthy humans. Cognitive Enhancement in CNS Disorders and Beyond accomplishes exactly that in a straightforward and accessible manner.

Bipolar Disorders

Bipolar Disorders Book
Author : Andreas Marneros,Frederick Goodwin
Publisher : Cambridge University Press
Release : 2005-10-06
ISBN : 9780521835176
Language : En, Es, Fr & De

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Book Description :

This book examines the full range of atypical, rapid cycling and transient forms of bipolar disorder.

Overcoming Avoidance Workbook

Overcoming Avoidance Workbook Book
Author : Daniel F. Gros
Publisher : New Harbinger Publications
Release : 2021-03-01
ISBN : 1684035686
Language : En, Es, Fr & De

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Book Description :

Stop avoiding and start living! Do you cope with anxiety by avoiding people, places, and situations that make you feel anxious? Do you deal with depression by isolating yourself from the people and activities that used to bring you joy? Do you avoid talking or thinking about the events that caused your post-traumatic stress disorder (PTSD)? If so, you’re not alone. Changing behavior in an attempt to avoid thinking or confronting things that are uncomfortable is a common symptom of anxiety, depression, PTSD, and related conditions. With this guide, you’ll develop skills based in transdiagnostic behavior therapy (TBT), an evidence-based protocol designed to help you identify and overcome the avoidance and isolation issues associated with depression, anxiety, and PTSD. You’ll also learn how to safely and gradually implement therapeutic techniques that will result in reduced symptoms and improved confidence. If you’re tired of hiding from difficult thoughts, emotions, and situations, this book will help you break the avoidance cycle at the heart of your disorder. It’s time to stop running from the life you want and start developing the effective coping skills you need to face life’s challenges with courage and confidence.

The American Psychiatric Publishing Textbook of Mood Disorders

The American Psychiatric Publishing Textbook of Mood Disorders Book
Author : Dan J. Stein,David J. Kupfer,Alan F. Schatzberg
Publisher : American Psychiatric Pub
Release : 2007-05-03
ISBN : 158562716X
Language : En, Es, Fr & De

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Book Description :

Psychiatrists and other mental health care and medical professionals can now turn to a truly authoritative, up-to-date reference for current information about mood disorders. The American Psychiatric Publishing Textbook of Mood Disorders -- including a wealth of illustrations, tables and references -- presents the state of the art in diagnosis, psychobiology, pharmacotherapy, and psychotherapy across the vast spectrum of mood disorders: Symptomatology and Epidemiology: historical aspects and social underpinnings of mood disorders, classification and rating scales, and global burden Pathogenesis: neurochemistry and psychoneuroendocrinology, cognitive processing models (experimental cognitive research), and evolutionary explanations Methods of Investigation:anatomical pathology, molecular and cellular neurobiology of severe mood disorders, and genetics of bipolar and unipolar disorders Types of Mood Disorder: psychotic depression, seasonal affective disorder, secondary depression with medical illness, major depression seen in primary care, and substance abuse, and sleep disorders Treatments: pharmacotherapy, brain stimulation techniques, and psychotherapies Pertinent Factors: personality, culture, and gender Offering a fascinating synthesis of the multifaceted field of mood disorders, the richly informative American Psychiatric Publishing Textbook of Mood Disorders will prove invaluable for psychiatric and medical practitioners, educators, students, and residents interested in the latest breakthroughs in the diagnosis, treatment, and management of mood disorders.

Science and Practice in Cognitive Therapy

Science and Practice in Cognitive Therapy Book
Author : Robert L. Leahy
Publisher : Guilford Publications
Release : 2018-01-05
ISBN : 1462533396
Language : En, Es, Fr & De

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Book Description :

From leading experts in cognitive-behavioral therapy (CBT)--including CBT originator Aaron T. Beck and many who have worked closely with him--this book provides an overview of where the field is today and presents cutting-edge research and clinical applications. Contributors explain how Beck's cognitive model has been refined and tested over the last 45 years and describe innovative CBT approaches that integrate mindfulness, imagery, emotion-focused interventions, and other strategies. Chapters on specific clinical problems cover the conceptualization and treatment of depression, anxiety disorders, posttraumatic stress disorder, obsessive–compulsive disorder, insomnia, suicidality, substance abuse, couple and family problems, bipolar disorder, psychosis, and personality disorders.

The Bipolar Book

The Bipolar Book Book
Author : Aysegul Yildiz,Pedro Ruiz,Charles Nemeroff
Publisher : Oxford University Press
Release : 2015-05-22
ISBN : 0199300542
Language : En, Es, Fr & De

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Book Description :

As a major mainstay of clinical focus and research today, bipolar disorder affects millions of individuals across the globe with its extreme and erratic shifts of mood, thinking and behavior. Edited by a team of experts in the field, The Bipolar Book: History, Neurobiology, and Treatment is a testament and guide to diagnosing and treating this exceedingly complex, highly prevalent disease. Featuring 45 chapters from an expert team of contributors from around the world, The Bipolar Book delves deep into the origins of the disorder and how it informs clinical practice today by focusing on such topics as bipolar disorder occurring in special populations, stigmatization of the disease, the role genetics play, postmortem studies, psychotherapy, treatments and more. Designed to be the definitive reference volume for clinicians, students and researchers, Aysegül Yildiz, Pedro Ruiz and Charles Nemeroff present The Bipolar Book as a "must have" for those caregivers who routinely deal with this devastating disease.

Neurobiology of Bipolar Disorder

Neurobiology of Bipolar Disorder Book
Author : Joao Quevedo,Andre Ferrer Carvalho,Eduard Vieta
Publisher : Academic Press
Release : 2020-11-25
ISBN : 012819183X
Language : En, Es, Fr & De

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Book Description :

The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches. Aids readers in understanding bipolar disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to novel therapeutics Synthesizes a discussion of the cellular and molecular mechanisms underlying symptoms with clinical aspects of bipolar disorder

Ketamine for Treatment Resistant Depression

Ketamine for Treatment Resistant Depression Book
Author : Gustavo H. Vazquez,Carlos A. Zarate,Elisa Brietzke
Publisher : Academic Press
Release : 2020-10-01
ISBN : 0128210346
Language : En, Es, Fr & De

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Book Description :

Ketamine for Treatment-Resistant Depression: Neurobiology and Applications provides a simple, evidence-based overview for neuropsychiatrists and translational researchers on this medication, its mechanisms of actions, eligibility of patients for treatment, and the preparation and implementation of ketamine clinics. Provides efficacy research on ketamine as a treatment for depression Identifies best practices for clinical use, both long-term and acute Discusses the molecular mechanisms and neurobiology of action

Committee Staff Report to the Chairman and Ranking Member

Committee Staff Report to the Chairman and Ranking Member Book
Author : Anonim
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Committee Staff Report to the Chairman and Ranking Member book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Clinical Guide to Depression and Bipolar Disorder

Clinical Guide to Depression and Bipolar Disorder Book
Author : Martin B. Keller,William H. Coryell,Jean Endicott,Jack D. Maser,Pamela J. Schettler
Publisher : American Psychiatric Pub
Release : 2013-04-10
ISBN : 1585629944
Language : En, Es, Fr & De

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Book Description :

Conceived in the early 1970s to study the phenomenology, diagnosis, genetics, and clinical course of depression, the NIMH Collaborative Depression Study (CDS) has influenced research and practice since its inception. Clinical Guide to Depression and Bipolar Disorder: Findings From the Collaborative Depression Study summarizes key findings from the study and the related literature to provide comprehensive and up-to-date knowledge on the course and outcome of illness in mood disorders. Nowhere else can clinicians find such detailed longitudinal data, combined with astute clinical analysis of the current research. The volume offers: Historical background on how psychodynamic psychiatry was overtaken by psychobiological perspectives, and the challenges and controversies that gave rise to the CDS, providing the context necessary to understand the profession's development to the present day. A wealth of information on nosology, natural history, phenomenology, and treatment response in depressive and bipolar disorders. Detailed descriptions of the study methods employed, providing information and insights that will assist researchers in the longitudinal design of prospective cohort studies. Comprehensive review of outcomes in mood disorder, including delineation of the long-term course of bipolar I, bipolar II, and unipolar major depressive disorders, the implications of which will continue to be instrumental in the development of psychiatric nosology and indispensable to clinicians engaged in assessment and treatment. Critical information clinicians need in order to read the clinical signs in their patients and predict the "switch" from unipolar to bipolar disorder. A fascinating review of the evolution of diagnostic thinking about the role of anxiety in mood disorders, and the contributions of the CDS to the newly published DSM-5®. Each chapter is accompanied by a time-saving summary, as well as a section on clinical implications that translates the findings into practical points and key recommendations clinicians need to know to provide optimal care. Psychiatrists, clinical psychologists, residents, and fellows will turn to Clinical Guide to Depression and Bipolar Disorder: Findings From the Collaborative Depression Study to better understand the course and outcome of their patients' mood disorders and, ultimately, to improve their clinical skills.

Polypharmacology in Drug Discovery

Polypharmacology in Drug Discovery Book
Author : Jens-Uwe Peters
Publisher : John Wiley & Sons
Release : 2012-03-13
ISBN : 0470590904
Language : En, Es, Fr & De

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Book Description :

"Covers the two-sided nature of polypharmacology--its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes. Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology"--Provided by publisher.

Cognitive Dimensions of Major Depressive Disorder

Cognitive Dimensions of Major Depressive Disorder Book
Author : Bernhard T. Baune,Catherine Harmer
Publisher : Oxford University Press, USA
Release : 2019-08
ISBN : 0198810946
Language : En, Es, Fr & De

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Book Description :

Major depressive disorder (MDD) is one of the most prevalent mental disorders worldwide, and is estimated to affect 300 million people. Most research defines MDD as a categorical disorder and investigations on clinical, functional, and biological correlates are assessed by established diagnostic instruments. However, given the phenotypic and biological heterogeneity of depression, a re-focus on the clinical phenotype of MDD is required. Bridging psychiatric and psychological traditions Cognitive Dimensions of Major Depressive Disorder, discusses the characteristics of the dimensional approach of MDD. Focusing on the cognitive and emotional processes of depression, this guide offers extended and novel diagnostic and treatment approaches ranging from pharmacological to psychological interventions targeting dimensions of depression. Edited by pioneers in this field, this resource discusses hot topics such as how to define the dimensional approach to depression, the neurobiological underpinnings of cognitive dysfunction in depression, and the impairment of emotional processing deficits in depression. Cognitive Dimensions of Major Depressive Disorder is suitable for students, trainees, clinicians and scientists in the fields of psychology, neuropsychology, psychiatry, cognitive neuroscience, neurology, general practice and also for various other health care professionals.