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Clinical Studies And Therapies In Parkinsons Disease

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Clinical Studies and Therapies in Parkinson s Disease

Clinical Studies and Therapies in Parkinson s Disease Book
Author : Juan Segura-Aguilar
Publisher : Academic Press
Release : 2021-06-12
ISBN : 0128221585
Language : En, Es, Fr & De

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Book Description :

More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson’s disease, but it remains the most common treatment despite inducing severe side effects such as dyskinesia after 4–6 years of use. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies for Parkinson’s disease, but these efforts have failed when attempting to transfer these successful results to preclinical studies. Although several publications have warned of these failures, the scientific community remains mostly unaware, and there is a need to focus their efforts on potential therapeutics that can slow or halt development of the disease. Clinical Studies and Therapies in Parkinson’s Disease: Translations from Preclinical Models analyzes preclinical models based on exogenous neurotoxins and why they have failed. Neuroscientists, neurologists, and neuropharmacologists will benefit greatly from the book’s discussion of these newer models, their benefits, and the need for their implementation. This book also provides the basic concepts of dopamine metabolism for students taking courses in neurochemistry, neuroscience, neuropharmacology, biochemistry, and medicine. Reviews Parkinson's disease classification, pharmacological therapies, and nonmotor and motor symptoms Analyzes preclinical models of Parkinson’s disease therapies based on exogenous neurotoxins and why they have failed Reviews genetic preclinical models based on genetic mutations and endogenous neurotoxins Proposes a more physiological model directly related to the metabolism of dopaminergic neurons Provides the basic concepts and mechanisms of dopamine metabolism

Selegiline in the Treatment of Parkinson s Disease

Selegiline in the Treatment of Parkinson s Disease Book
Author : Esa Heinonen
Publisher : Unknown
Release : 1995
ISBN : 9789512904419
Language : En, Es, Fr & De

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Book Description :

Download Selegiline in the Treatment of Parkinson s Disease book written by Esa Heinonen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Early Diagnosis and Preventive Therapy in Parkinson s Disease

Early Diagnosis and Preventive Therapy in Parkinson   s Disease Book
Author : Horst Przuntek,Peter Riederer
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3709189942
Language : En, Es, Fr & De

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Book Description :

At the time when "Parkinson's Disease" is diagnosed in a patient, roughly two thirds of dopaminergic neurons of substantia nigra are already degenerated. The onset of the disease must, therefore, be much earlier. This book deals with early diagnosis and early preventive treatment which may sustain the process underlying the disease. By use of psychometric, kinesiologic, physiologic, histologic, biochemical, endocrinologic, pharmacologic and imaging techniques, including positron-emission tomography and brain mapping, specialists tried to focus on new diagnostic criteria. New methods including psychometric evaluation, apparative measurement of movement, analysis of peripheral blood and urinary constituents have supplemented this approach. It has been agreed that early preventive therapy consists of low dosis of L-DOPA plus benserazide, L-deprenyl and dopaminergic agonists.

Restorative Therapies in Parkinson s Disease

Restorative Therapies in Parkinson s Disease Book
Author : Patrik Brundin,C. Warren Olanow
Publisher : Springer Science & Business Media
Release : 2006-08-31
ISBN : 0387328238
Language : En, Es, Fr & De

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Book Description :

In this exciting and timely book new approaches to repairing the parkinsonian brain are described by leading experts. Never in history has there been greater hope that novel experimental therapies can support significant restoration of brain function. This book gives an overview of the current state-of-the-art research for brain repair, what the challenges are and an indication of what research can provide for the next generation of people with Parkinson’s disease. The comprehensive chapters are geared to an audience of neuroscientists, neurologists, neurosurgeons and anyone interested in how findings in the research laboratory can effectively be transferred to the clinic.

Recent Advances in Parkinson s Disease

Recent Advances in Parkinson s Disease Book
Author : Anonim
Publisher : Academic Press
Release : 2020-04-02
ISBN : 0444642617
Language : En, Es, Fr & De

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Book Description :

Recent Advances in Parkinson ́s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?, Molecular basis of selective neuronal vulnerability in PD, Role of innate and adaptive immunity in Parkinson ́s disease, and much more. Covers all key aspects of current research on Parkinson ́s disease Includes topics that range from basic studies on disease models and pathogenic pathways (e.g., protein misfolding, immune and glial mechanisms) to clinical studies on disease features, microbiome, pathophysiology and therapeutic approaches Presents articles authored by world leaders in their respective fields

Therapeutics of Parkinson s Disease and Other Movement Disorders

Therapeutics of Parkinson s Disease and Other Movement Disorders Book
Author : Mark Hallett,Werner Poewe
Publisher : John Wiley & Sons
Release : 2008-10-13
ISBN : 047071400X
Language : En, Es, Fr & De

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Book Description :

Provides a comprehensive update on therapies for Parkinson’s disease and other movement disorders Describes the basic mechanisms of neurodegeneration, pharmacologic interventions for motor and non-motor symptoms, and surgical management Features summary tables and algorithms that serve as a quick reference guide for practical treatment decisions The expert guidance of recognised authorities will enable readers of this book to plan their patients’ care with greater confidence

Recent Advances in Parkinsons Disease

Recent Advances in Parkinsons Disease Book
Author : Anonim
Publisher : Elsevier
Release : 2010-08-20
ISBN : 0444536248
Language : En, Es, Fr & De

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Book Description :

This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods. Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications. Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research. All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist.

Towards New Therapies for Parkinson s Disease

Towards New Therapies for Parkinson s Disease Book
Author : David Finkelstein
Publisher : BoD – Books on Demand
Release : 2011-11-02
ISBN : 9533074639
Language : En, Es, Fr & De

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Book Description :

Parkinson's disease (PD) is characterised clinically by various non-motor and progressive motor symptoms, pathologically by loss of dopamine producing cells and intraneuronal cytoplasmic inclusions composed primarily of ?-synuclein. By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a significant proportion of the cells in the substantia nigra have already been destroyed. This degeneration progresses despite the current therapies until the cell loss is so great that the quality of normal life is compromised. The dopamine precursor levodopa is the most valuable drug currently available for the treatment of PD. However for most PD patients, the optimal clinical benefit from levodopa decreases around five to six years of treatment. The aim of the chapters of this book is to work towards an understanding in the mechanisms of degeneration and to develop disease modifying therapies.

Neurotherapeutics in the Era of Translational Medicine

Neurotherapeutics in the Era of Translational Medicine Book
Author : Richard A. Smith,Brian K. Kaspar,Clive N. Svendsen
Publisher : Academic Press
Release : 2020-11-28
ISBN : 0128172746
Language : En, Es, Fr & De

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Book Description :

For the first time in history, there is now hope for treating neurological disorders that had previously been considered untreatable. The remarkable confluence of events that has heralded this is the focus of Neurotherapeutics in the Era of Translational Medicine. This anthology, written by many of the prominent scientists and researchers in the field of biotechnology, recounts the breathtaking advances that are revolutionizing treatment for disorders such as amyotrophic lateral sclerosis‎, spinal muscular atrophy, multiple sclerosis, Parkinson’s disease, myasthenia gravis, migraine, and glioblastoma. The "story behind the story" of these translational efforts is told, with authors depicting the ups and downs encountered on the path of their drug discovery and development effort. In parallel with this path, advances in identifying novel biomarkers and disease models are summarized, as are contemporary issues focusing on clinical trial design, bioethics, innovative funding strategies, and collaborations between government and academia in an effort to facilitate breakthrough treatments. The book is written by members of the biotech and pharmaceutical ecosystem for those who belong to it and aspire to become part of it. Comprehensive review on the progress of translational research in neurotherapeutics for neurologic disorders Discusses important issues in clinical trials such as design and ethical issues Written for neuroscientists, neurologists and pharmacologists

Parkinson s Disease

Parkinson s Disease Book
Author : Hirotaro Narabayashi,Toshiharu Nagatsu,Nobuo Yanagisawa,Yoshikuni Mizuno
Publisher : Lippincott Williams & Wilkins
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This volume contains the edited proceedings of the Tenth International Symposium on Parkinson's Disease, and provides a comprehensive account of the latest advances worldwide in the study and treatment of parkinsonian syndromes. With contributions from more than 400 leading international authorities, the book presents an overview of the wide spectrum of current basic and clinical research and therapy - from studies using the most advanced neurochemical and molecular biological techniques, to new insights into the clinical picture of the parkinsonian patient and recent breakthroughs in drug therapy and tissue transplant surgery. Coverage includes neuroanatomical, neurophysiological, neurochemical, neuropharmacological, and molecular biological studies on the dynamics of the basal ganglia in movement disorders and on the neuronal degenerative process in Parkinson's disease. Close attention is given to the role of monoamine oxidase-B (MAO-B), hydroxyl and superoxide radicals, iron, and MPTP-like neurotoxins in the etiology of Parkinson's disease, as well as to new findings on the genetics of the disease. Noted experts describe the clinical physiology of motor disorders and discuss cognitive dysfunction and dementia in Parkinson's disease. Conditions such as juvenile parkinsonism, heredity progressive dystonia, and dopa-responsive dystonia are also intensively discussed as purely dopaminergic disorders. Other contributors describe applications of MRI, PET, and SPECT in clinical research on parkinsonism and dystonic disorders and analyze neuropathological findings in Parkinson's disease and symptomatic parkinsonism. The section on drug therapy includes extensive clinical data on new Sinemet formulations, apomorphine and lisuride infusion, MAO-B inhibitors, and L-threo-DOPS, as well as promising suggestions for future treatment strategies. Full consideration is given to the factors affecting response to drug treatment and management of side effects such as drug induced dyskinesia or psychosis. The book also includes detailed reports on the techniques and clinical outcome of fetal mesencephalic tissue transplantation. This volume is an indispensable reference for all neurologists, neurosurgeons, and neuroscientists, as well as for pharmacologists developing new therapeutic agents for parkinsonism and other neurodegenerative diseases.

Clinical Trials In Parkinson s Disease

Clinical Trials In Parkinson s Disease Book
Author : Santiago Perez-Lloret
Publisher : Humana
Release : 2021-09-02
ISBN : 9781071609149
Language : En, Es, Fr & De

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Book Description :

This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson’s Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection. Chapters in this book discuss topics such as toxin-based rodent or genetic models of PD; clinical trials for motor symptoms, L-DOPA related motor complications, and gait disorders; clinical trials for mood disorders, troubled sleep, autonomic dysfunction; and clinical trials for disease modifying therapies. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory or research center. Cutting-edge and authoritative, Clinical Trials in Parkinson’s Disease is a valuable resource for clinicians and researchers who want to enhance their interpretation of results from clinical trials and to design their own high-quality trials.

Balance Dysfunction in Parkinson s Disease

Balance Dysfunction in Parkinson   s Disease Book
Author : Martina Mancini,John G. Nutt,Fay B. Horak
Publisher : Academic Press
Release : 2019-09-14
ISBN : 0128138750
Language : En, Es, Fr & De

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Book Description :

Balance Dysfunction in Parkinson’s Disease: Basic Mechanisms to Clinical Management presents the most updated information on a variety of topics. Sections help clinicians evaluate the types of balance control issues, dynamic balance dysfunction during turning, and the effects of medication, deep brain stimulation, and rehabilitation intervention on balance control. This book is the first to review the four main postural control systems and how they are affected, including balance during quiet stance, reactive postural adjustments to external perturbations, anticipatory postural adjustments in preparation for voluntary movements, and dynamic balance control during walking and turning. In addition, the book's authors summarize the effects of levodopa, deep brain stimulation, and rehabilitation intervention for each balance domain. This book is recommended for anyone interested in how and why balance control is affected by PD. Provides the first comprehensive review of research to date on balance dysfunctions in Parkinson's disease Discusses how to translate current neuroscience research into practice regarding neural control of balance Provides evidence on the effects of current interventions on balance control

Catechol O methyltransferase Inhibition in the Treatment of Parkinson s Disease

Catechol O methyltransferase Inhibition in the Treatment of Parkinson s Disease Book
Author : Hanna Ruottinen,Turun yliopisto
Publisher : Unknown
Release : 1998
ISBN : 9789512912612
Language : En, Es, Fr & De

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Book Description :

Download Catechol O methyltransferase Inhibition in the Treatment of Parkinson s Disease book written by Hanna Ruottinen,Turun yliopisto, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Parkinson s Disease

Parkinson s Disease Book
Author : Chiyo Yoshida,Ami Ito
Publisher : Nova Biomedical
Release : 2012
ISBN : 9781619428300
Language : En, Es, Fr & De

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Book Description :

Parkinson's disease (PD) is the second most common neurodegenerative disorder and is caused by degeneration and dysfunction of dopaminergic neurons in substantia nigra. The disease usually clinically starts at age 54-60 and the mean duration from diagnosis to death is about 15 years. In this book, the authors study the diagnosis, treatment and prognosis of Parkinson's disease. Topics include palliative care in Parkinson's disease; therapeutic interventions based on the modulation of cellular degradative systems in Parkinson's physiopathology; Parkinson's disease related changes of oscillatory activity in discrimination tasks; Deep Brain Stimulation (DBS) and Parkinson's disease; and the genetic aspects for diagnosis of Parkinson's disease in different populations.

Novel Therapeutic Approaches to the Treatment of Parkinson s Disease

Novel Therapeutic Approaches to the Treatment of Parkinson   s Disease Book
Author : Corey R. Hopkins
Publisher : Springer
Release : 2016-06-23
ISBN : 3319399268
Language : En, Es, Fr & De

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Book Description :

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Gene Therapy of the Central Nervous System From Bench to Bedside

Gene Therapy of the Central Nervous System  From Bench to Bedside Book
Author : Michael G. Kaplitt,Matthew During
Publisher : Gulf Professional Publishing
Release : 2006
ISBN : 9780123976321
Language : En, Es, Fr & De

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Book Description :

Few areas of biomedical research provide greater opportunities for radically new therapies for devastating diseases that have evaded treatment so far than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy of the Central Nervous System: From Bench to Bedside represents the first definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped create this field and are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects of interest to anyone exploring or using gene therapy for neurobiological applications in research and clinical praxis. * Presents gene transfer technologies with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells * Discusses preclinical areas that are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis * Includes "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use

10 Breakthrough Therapies for Parkinson s Disease

10 Breakthrough Therapies for Parkinson s Disease Book
Author : Michael Okun
Publisher : Books4patients
Release : 2015-08-21
ISBN : 9780692497418
Language : En, Es, Fr & De

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Book Description :

Michael S. Okun, M.D. is internationally celebrated as both a neurologist and a leading researcher. He has often been referred to as, "the voice of the Parkinson's disease patient." He was honored at the White House in 2015 as a Champion of Change for Parkinson's disease. He has an international following on the National Parkinson Foundation's Ask the Doctor web-forum and he is a Professor of Neurology at the University of Florida Health Center for Movement Disorders and Neurorestoration. His many books and internet blog posts are brimming with up-to date and extremely practical information. This book is the sequel to his runaway bestseller, Parkinson's Treatment: 10 Secrets to a Happier Life, which was translated into over 20 languages. Dr. Okun is well known for infusing his readers with positivity and optimism. In his latest book he reveals the breakthroughs in Parkinson's disease that will pave the road to meaningful progress. In this book he reviews all of the recent breakthrough ideas and therapies in Parkinson's disease, and he reviews the knowledge gained which is extending far beyond a single drug or stem cell. He paints the broader and more exciting picture and reviews the portfolio of breakthroughs spanning drug, cell, vaccine, device, genetics, care, and behavior. He believes that patients and families with personal investments in Parkinson's disease should be informed and updated about all of these potential breakthrough therapies. This book informs, educates, and will inspire Parkinson's disease patients, family members, as well as health care professionals and scientists. As Dr. Okun points out, we will journey toward better treatments -- and one day a cure.

The Molecular and Cellular Basis for Parkinson s Disease

The Molecular and Cellular Basis for Parkinson s Disease Book
Author : Thomas Müller
Publisher : MDPI
Release : 2019-10-14
ISBN : 3039215485
Language : En, Es, Fr & De

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Book Description :

The focus on dopamine-sensitive motor symptoms, in association with the improvement of motor complications in the heterogeneous disease entity Parkinson's disease, has led to a certain standstill in research.This Special Issue provides new concepts and new ideas on the pathogenesis, genetics, and clinical maintenance of Parkinson's disease and related disorders. Not only new experimental findings, but also clinical outcomes, case series, and research on alternative, non-pharmacological therapies are included.The objective is to bridge the currently increasing gap between experimental and clinical research on Parkinson's disease and related disorders.

Rethinking Parkinson s Disease

Rethinking Parkinson s Disease Book
Author : John C Coleman
Publisher : Hybrid Publishers
Release : 2020-10-08
ISBN : 1925736474
Language : En, Es, Fr & De

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Book Description :

John Coleman was diagnosed with Parkinson's disease while studying to be a naturopath, and banished all the frustrating symptoms of this cruel condition from his body ... naturally! His new book equips those diagnosed with the knowledge needed to reverse their Parkinson's disease symptoms and even recover, using completely natural means. Rethinking Parkinson's Disease traces known pathways leading to a diagnosis of Parkinson's disease, together with strategies to reverse each pathway. It includes the best evidence from Western allopathic medicine and complementary/alternative medicine in discovering how and why people with Parkinson's develop symptoms, the diagnostic process, standard treatments and prognoses offered by expert practitioners, and ongoing research. The book presents strategies that have been shown, clinically or in research, to improve the health of people with Parkinson's, with the possibility of reversing symptoms. A major section of this work details strategies to create wellness, many available to patients at little or no cost. There are sections on symptom control, complementary medical treatments and therapies to avoid. The book is aimed primarily at people with Parkinson's, families and supporters, and may be used as a self-help book, including advice on building a team of supportive practitioners. There are also suggestions and advice for both Western allopathic medicine and complementary/alternative medicine practitioners to enhance their care of patients with a Parkinson's disease diagnosis, so it may be used as a handbook for practitioners wishing to move away from the standard conservative view of Parkinson's disease as an "incurable" disease.

Levodopa Induced Dyskinesia in Parkinson s Disease

Levodopa Induced Dyskinesia in Parkinson s Disease Book
Author : Susan H. Fox,Jonathan M. Brotchie
Publisher : Springer
Release : 2014-10-08
ISBN : 1447165039
Language : En, Es, Fr & De

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Book Description :

This book aims to provide a single reference source on levodopa-induced dyskinesias (LID) from ‘bench to bedside’. Initial chapters review the clinical features and phenomenology of LID with video examples; epidemiology and genetic risk factors for LID are covered as a background to understanding risk factors for developing LID. The following chapters cover the latest preclinical studies aiming to understand the pathophysiology of LID at the cellular, neurochemical, neurophysiological and circuitry level with detailed discussion of mechanisms and future directions to take the field forward; clinical studies from phase II to phase IV; on going RCTs in LID and evidence-based medicine reviews of treatment options. Levodopa-Induced Dyskinesia in Parkinson’s Disease is aimed at an international audience of movement disorder neurologists; neuroscientists; trainees and graduate and post-graduate students.