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Clinical Perspectives And Targeted Therapies In Apoptosis

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Clinical Perspectives and Targeted Therapies in Apoptosis

Clinical Perspectives and Targeted Therapies in Apoptosis Book
Author : Rupinder K. Sodhi,Jitender Madan
Publisher : Academic Press
Release : 2020-10-30
ISBN : 0128157631
Language : En, Es, Fr & De

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Book Description :

Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention provides comprehensive coverage, from basic cell biology, to modern assessment techniques for apoptosis in all major disease areas. Chapters provide an introduction to the fundamentals of cell biology, biochemical mechanisms, and the pathophysiological consequences of apoptosis. In addition, the book covers the tools and techniques used to quantify apoptosis and the significance of apoptosis in drug discovery, drug delivery, and its applications in disease prevention. Finally, the book provides a comprehensive compilation of the apoptosis targeting drugs that recently underwent clinical trials. This combination of fundamentals, along with applications in drug discovery, drug delivery, and clinical research make this book a useful resource for those in both academia and industry who are engaged in pharmaceutical, biomedical and biotechnology research. Offers standard and innovative therapeutic approaches to modulate apoptosis in clinical interventions, such as cardiovascular diseases, immune disorders, cancer chemotherapy and neurological ailments Covers cutting-edge laboratory techniques and traditional protocols to determine apoptosis, both in vitro and in vivo Examines clinical study reports of new drug moieties that are explored for various pathological conditions associated with apoptosis

Cumulated Index Medicus

Cumulated Index Medicus Book
Author : Anonim
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Index Medicus

Index Medicus Book
Author : Anonim
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Index Medicus book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Targeted Therapy in Translational Cancer Research

Targeted Therapy in Translational Cancer Research Book
Author : Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson,Maurie Markman
Publisher : John Wiley & Sons
Release : 2015-12-21
ISBN : 1118468570
Language : En, Es, Fr & De

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Book Description :

Translational medicine has opened the gateway to the era of personalized medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. Translational Oncology: Targeted Therapy in Translational Cancer Research provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains the clinical ramifications and utility of these on targeted cancer therapies. Beginning with a chapter introducing the “Bench to Bedside and Back” paradigm, an overview is presented of the exponential growth in the field of translational medicine, including historical perspectives and recent progress. Following the introduction, subsequent chapters review the progress of targeted therapy within three major categories: hematological malignancies, solid tumors, and hereditary cancers. Each of these categories comprises a single a chapter with subsections that discuss specific cancer types. Following this is a chapter on targeted and functional imaging that reviews progress in the different modalities of anatomical and molecular imaging used to complement targeted therapy. The next chapter discusses the need to combine individual agents with existing therapies or in novel combinations in order to overcome drug resistance. Following this is a chapter presenting the challenges in drug development and the selection of targets for cancer therapeutics. The final chapter offers perspectives on personalized medicine and presents future challenges in the investigation of optimal combinations and the identification of biomarkers that can provide both predictive and prognostic information for tailoring targeted therapies to individual patients.

Head Neck Cancer Current Perspectives Advances and Challenges

Head   Neck Cancer  Current Perspectives  Advances  and Challenges Book
Author : James A. Radosevich
Publisher : Springer Science & Business Media
Release : 2013-05-24
ISBN : 9400758278
Language : En, Es, Fr & De

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Book Description :

This is a nearly complete collection of Chapters that provide an up to date overview of all aspects of Head and Neck cancer. It is written by professionals but is not only intended for other professionals, but students, patients, policy makers, etc. There are so many aspects to this group of diseases that even the most seasoned professional will learn something from having read this book.

Pharmaceutical Perspectives of Cancer Therapeutics

Pharmaceutical Perspectives of Cancer Therapeutics Book
Author : Yi Lu,Ram I. Mahato
Publisher : Springer Science & Business Media
Release : 2009-06-23
ISBN : 9781441901316
Language : En, Es, Fr & De

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Book Description :

Pharmaceutical Perspectives of Cancer Therapeutics covers a wide variety of therapeutic approaches including gene therapy, immunological therapy; cancer vaccines; strategy for solid tumors as well as for hematological cancers; methods to suppress tumor angiogenesis and metastasis; development and utilization of relevant animal models; introduction of new concepts such as cancer stem cells and new technologies, such as DNA and tissue microarrays; and RNA interference. In addition, clinical application, the development of DNA diagnosis biomarkers and cancer prevention, as well as the utilization of imaging in cancer therapy are also discussed. The use of synthetic carriers, such as lipids, polymers, and peptides for delivery and targeting of small molecules, proteins, and nucleic acids to cancer cells in vivo are discussed. Pharmaceutical Perspectives of Cancer Therapeutics also includes cancer therapy modality in surgery, chemotherapy, and radiotherapy, as well as in combination or multi-modality, giving our book a more focused view of cancer therapy.

Oral and Maxillofacial Surgery

Oral and Maxillofacial Surgery Book
Author : Raymond J. Fonseca
Publisher : Saunders
Release : 2009
ISBN : 9781416066552
Language : En, Es, Fr & De

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Book Description :

This comprehensive resource provides in-depth information to help you perfect your oral and maxillofacial surgical technique and provide state-of-the-art care for your patients. The full scope of the field is represented with up-to-date, evidence-based coverage of every surgical procedure performed today. Volume I: Anesthesia and Pain Control, Dentoalveolar Surgery, Practice Management, Implant Surgery brings you authoritative coverage of office-based procedures, including extractions, implants, and biopsies. [editor].

BMJ

BMJ Book
Author : Anonim
Publisher : Unknown
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download BMJ book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Molecular Targeting in Oncology

Molecular Targeting in Oncology Book
Author : Howard L. Kaufman,Scott Wadler,Karen Antman
Publisher : Springer Science & Business Media
Release : 2007-12-26
ISBN : 9781597453370
Language : En, Es, Fr & De

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Book Description :

This book presents an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer. It is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice.

Clinical Ophthalmology Contemporary Perspectives E Book

Clinical Ophthalmology  Contemporary Perspectives   E Book Book
Author : A.K. Gupta
Publisher : Elsevier Health Sciences
Release : 2012-05-14
ISBN : 8131231658
Language : En, Es, Fr & De

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Book Description :

Many new developments have taken place in ophthalmology since the publication of the last edition. It therefore became mandatory to revise and update the present edition. To accomplish this many new chapters have been added and the existing ones revised. Thoroughly revised and updated chapters Recent Advances in Lamellar Keratoplasty Principles of Molecular Genetics Intraocular Tumours Recent Advances in Oculoplastic Surgery Ophthalmic Electrodiagnostic Techniques Ultrasonography in Ophthalmology Ocular Coherence Tomography Anterior Segment Trauma Corneal Topography and Wavefront Sensing

Topics in Arrhythmias and Ischemic Heart Disease

Topics in Arrhythmias and Ischemic Heart Disease Book
Author : Dr. Craig T. Basson, MD, PhD,Dr. Bruce B. Lerman, MD
Publisher : Demos Medical Publishing
Release : 2009-12-15
ISBN : 9781935281740
Language : En, Es, Fr & De

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Book Description :

In order to provide the latest and most sophisticated treatment the cardiology clinician must have current knowledge of a vast amount of translational research in the pathophysiology of these disorders as well as be aware of recent advances and issues in pharmacogenic and interventional therapies. Topics in Arrhythmias and Ischemic Heart Disease provides expert reviews and assessment of the most recent clinical research and on current trends in evaluation, diagnosis, and clinical management. Reviews include assessment of emerging data and indications of likely key advances with signifiacnt impact on clinical research in the near future. This volume is a must-have for every cardiologist needing to be fully current on recent advances in ischemic heart disease and arrhythmic disorders. About the Series Developed by expert faculty at the Cornell Division of Cardiology, the Emerging Concepts in Cardiology series edited by Craig T. Basson and Bruce B. Lerman, provides "state of the art reviews" of each topic from a clinical perspective, with expert perspectives in current clinical research and emerging basic and traditional research issues all in a concise, attractive and well-illustrated texts.

Perspectives in Gene Expression

Perspectives in Gene Expression Book
Author : Krishnarao Appasani
Publisher : Eaton Publishing Company
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Perspectives in Gene Expression book written by Krishnarao Appasani, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

American Journal of Respiratory and Critical Care Medicine

American Journal of Respiratory and Critical Care Medicine Book
Author : Anonim
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download American Journal of Respiratory and Critical Care Medicine book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cancer Drug Design and Discovery

Cancer Drug Design and Discovery Book
Author : Stephen Neidle
Publisher : Academic Press
Release : 2013-09-30
ISBN : 0123972280
Language : En, Es, Fr & De

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Book Description :

Cancer Drug Design and Discovery, Second Edition is an important reference on the underlying principles for the design and subsequent development of new anticancer small molecule agents. New chapters have been added to this edition on areas of particular interest and therapeutic promise, including cancer genomics and personalized medicine, DNA-targeted agents and more. This book includes several sections on the basic and applied science of cancer drug discovery and features those drugs that are now approved for human use and are in the marketplace, as well as those that are still under development. By highlighting some of the general principles involved in taking molecules through basic science to clinical development, this book offers a complete and authoritative reference on the design and discovery of anticancer drugs for translational scientists and clinicians involved in cancer research. Provides a clinical perspective on the development of new molecularly targeted anticancer agents with the latest and most promising chemotherapeutic approaches Offers a broad view of where the field is going, what tools drug discovery is using to produce new agents and how they are evaluated in the laboratory and clinic Features 6 new chapters devoted to advances in technology and successful anticancer therapies, such as cancer genomics and personalized medicine, DNA-targeted agents, B-Raf inhibitors and more Each chapter includes extensive references to the primary and review literature, as well as to relevant web-based sources

Seminars in Diagnostic Pathology

Seminars in Diagnostic Pathology Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Alternative and Complementary Therapies for Cancer

Alternative and Complementary Therapies for Cancer Book
Author : Moulay Alaoui-Jamali
Publisher : Springer Science & Business Media
Release : 2010-09-02
ISBN : 9781441900203
Language : En, Es, Fr & De

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Book Description :

Cancer is a common disease with a devastating impact on the physical and psychological well being of patients. The diagnosis of cancer brings upon many clinical challenges and questions for which clear and simple answers are not always provided by modern medicine. To date, only limited therapeutic options are available for patients with advanced cancer. The recent shift toward targeted therapies has improved substantially patient’s survival, however, relapses are frequent and cure remains rare. This led patients and many health care managers to shift attention to the holistic approach of traditional medicine particularly preparations from herbal products to manage and alleviate the disease. Typically, herbal preparations contain single or multiple plant ingredients, including a number of potential active components. Yet, they remain classified as food supplements and thus are exempt from regulations on quality control and proof of efficacy that govern standard pharmaceuticals. Clinical evidence for many preparations is often based on non-documented or anecdotal evidence. In consequence, several preparations with unproven efficacy are circulating in the market with the fear of interference with standard cancer therapies and/or severe toxicity that some can generate, in addition to the unjustified economical burden to patients. Despite inconsistent and conflicting clinical results single molecules have been isolated from herbal preparations and many are exploited to develop potential novel agents. This has fostered the need to organize a set of timely, in-depth and up-to-date review covering the latest developments in alternative cancer management from a scientific and clinical perspective dedicated to the medical community and health care providers, as well as to patients and their families. This book brings the latest comprehensive cancer information and practical recommendations on the best documented practice of alternative therapies for cancer management put together by recognized experts in the fields of medical oncology, traditional medicine, and cancer pharmacology. It goes hand-in-hand with the patient’s medical treatment options, quality of life issues, and more. The book is organized into four major sections: The first is an overview of the cancer syndrome by renowned medical oncologists from the USA and Europe. The second is a comprehensive description of traditional medicine by renowned experts from China and Germany. The third is an overview on the pharmacological impact of herb-based formulations on standard chemotherapy agents used in clinical practice. The fourth is a survey of cases reports from several hospitals with approved practice of alternative medicine. The book will feature simple definitions and essential information grouped in both medical and lay-term terminology, and straightforward illustrations related to human physiology, disease definition, scientific data on know and potential mechanisms of action, and preventive approaches. Finally, the book will feature collaboration of experts from China, India, USA, Canada, Germany, France, and other centres with recognized expertise in alternative/traditional medicine. This international cooperation is crucial to cover the complex topic of alternative therapies for cancer.

Mastocytosis An Issue of Immunology and Allergy Clinics

Mastocytosis  An Issue of Immunology and Allergy Clinics  Book
Author : Cem Akin
Publisher : Elsevier Health Sciences
Release : 2014-04-25
ISBN : 0323297102
Language : En, Es, Fr & De

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Book Description :

This issue of Immunology and Allergy Clinics, edited by Dr. Cem Akin, is devoted to Mastocytosis. Articles in this issue include Human Mast Cell Signal Transduction; Mast cell tryptase role in homeostasis and coagulation; Mastocytosis: Current Classification and Diagnostic criteria; Epidemiology, risk factors and prognosis of mastocytosis; Mast cell sarcoma: Clinical management; Molecular defects in mastocytosis: c-kit mutations and beyond; Flow cytometry in mastocytosis: Utility as a diagnostic and prognostic tool; Morphology of mastocytosis with special reference to immunophenotypical aberrancies; CD30 expression in mastocytosis; Extramedullary mastocytosis: Pathologic aspects; Bone involvement and osteoporosis in mastocytosis; Drug allergy in mastocytosis; Eosinophilia in mastocytosis; Venom allergy and mastocytosis; Skin disease in mastocytosis; Treatment of advanced mastocytosis; Treatment strategies of mediator related symptoms in mastocytosis; and Neuro and psychological involvement in Mastocytosis.

Cell Death Signaling in Cancer Biology and Treatment

Cell Death Signaling in Cancer Biology and Treatment Book
Author : Daniel Johnson
Publisher : Springer Science & Business Media
Release : 2012-11-19
ISBN : 1461458471
Language : En, Es, Fr & De

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Book Description :

A key goal in the treatment of cancer is to achieve selective and efficient killing of tumor cells. The aim of Cell Death Signaling in Cancer Biology and Treatment is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described. The potential for targeting microRNAs will be discussed. Multiple chapters will describe preclinical and clinical approaches that are currently being used to target epigenetic modifications, DNA repair pathways, and protein chaperones, as a means of provoking tumor cell death. Finally, the development and application of novel agents and approaches for targeting specific components of cell death signaling pathways and machinery will be reviewed.

Anticancer Research

Anticancer Research Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Anticancer Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.