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Clinical Bioenergetics

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Clinical Bioenergetics

Clinical Bioenergetics Book
Author : Sergej M. Ostojic
Publisher : Academic Press
Release : 2020-11-12
ISBN : 0128227729
Language : En, Es, Fr & De

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Book Description :

Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics, as well as the safety and efficacy of emerging management strategies to address poor cellular bioenergetics. Topics discussed include the omics landscape of impaired mitochondrial bioenergetics, hormones, tissue bioenergetics and metabolism in humans. Disease-specific case studies, modes of analysis in clinical bioenergetics, and therapeutic opportunities for impaired bioenergetics, addressing both known treatment pathways and future directions for research, are discussed in-depth. Diseases and Disorders examined include brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among others. Provides a thorough discussion of foundational aspects of bioenergetics and disease, modes of analysis, and treatments for impaired bioenergetics Discusses the role of bioenergetics and treatment pathways in brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among other diseases and disorders Features chapter contributions from international leaders in translational bioenergetics research and clinical practice

Clinical Bioenergetics

Clinical Bioenergetics Book
Author : Michael Galitzer
Publisher : Unknown
Release : 1994-06-01
ISBN : 9781885325006
Language : En, Es, Fr & De

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Book Description :

Download Clinical Bioenergetics book written by Michael Galitzer, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Bioenergetics

Bioenergetics Book
Author : David G. Nicholls
Publisher : Academic Press
Release : 2013-05-20
ISBN : 0123884314
Language : En, Es, Fr & De

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Book Description :

Extensively revised, the fourth edition of this highly successful book takes into account the many newly determined protein structures that provide molecular insight into chemiosmotic energy transduction, as well as reviewing the explosive advances in 'mitochondrial physiology'-the role of the mitochondria in the life and death of the cell. Covering mitochondria, bacteria and chloroplasts, the fourth edition of Bioenergetics provides a clear and comprehensive account of the chemiosmotic theory and its many applications. The figures have been carefully designed to be memorable and to convey the key functional and mechanistic information. Written for students and researchers alike, Bioenergetics is the most well-known, current and respected text on chemiosmotic theory and membrane bioenergetics available. BMA Medical Book Awards 2014-Highly Commended, Basic and Clinical Sciences,2014,British Medical Association Chapters are now divided between three interlocking sections: basic principles, structures and mechanisms, and mitochondrial physiology. Covers new advances in the structure and mechanism of key bioenergetic proteins, including complex I of the respiratory chain and transport proteins. Details cellular bioenergetics, mitochondrial cell biology and signal transduction, and the roles of mitochondria in physiology, disease and aging. Offers readers clear, visual representation of structural concepts through full colour figures throughout the book.

Lean on Me

Lean on Me Book
Author : Nancy Sue Davis
Publisher : Simon and Schuster
Release : 2006
ISBN : 9780743276405
Language : En, Es, Fr & De

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Book Description :

Outlines a ten-step program for taking charge of one's life after a life-altering or life-threatening health diagnosis, describing the author's experiences with helping sick and injured family members while revealing her own struggles with multiple sclerosis. 50,000 first printing.

Which Degree in Britain

Which Degree in Britain Book
Author : Anonim
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A comprehensive guide to full-time degree courses, institutions and towns in Britain.

Biomedical and Clinical Aspects of Coenzyme Q

Biomedical and Clinical Aspects of Coenzyme Q Book
Author : Yūichi Yamamura
Publisher : Elsevier Science & Technology
Release : 1981
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biomedical and Clinical Aspects of Coenzyme Q book written by Yūichi Yamamura, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Coenzyme Q

Coenzyme Q Book
Author : Giorgio Lenaz
Publisher : John Wiley & Sons Incorporated
Release : 1985
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

It is becoming increasingly apparent that Coenzyme Q (Ubiquinone) is a major component of the electron transfer chains within aerobic micro-oganisms, photo-synthetic micro-organisms and mitochondria of eukaryotes. In particular, the proposal by Nobel laureate, Peter Mitchell, that Coenzyme Q possibly acts as a proton translocator within a proton motive Q-cycle, thus establishing an electrochemical membrane potential which in turn drives ATP synthesis, has received wide attention. This exhaustive, inter-disciplinary study discusses Ubiquinone's chemical and physical properties, metabolism, and function in different organisms.

Biomedical and Clinical Aspects of Coenzyme Q

Biomedical and Clinical Aspects of Coenzyme Q Book
Author : Karl August Folkers,Yūichi Yamamura
Publisher : Elsevier Science & Technology
Release : 1986
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biomedical and Clinical Aspects of Coenzyme Q book written by Karl August Folkers,Yūichi Yamamura, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Which Degree

Which Degree  Book
Author : Anonim
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Which Degree book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Miracle Nutrient

The Miracle Nutrient Book
Author : Emile G. Bliznakov
Publisher : Bantam
Release : 1987
ISBN : 9780553262339
Language : En, Es, Fr & De

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Book Description :

Discusses the latest information on a scientific breakthrough that can strengthen the heart, boost the immune system, and extend life and includes a reference section on sources of this nutrient for consumers

The Dictionary of Physiological and Clinical Psychology

The Dictionary of Physiological and Clinical Psychology Book
Author : Rom Harré,Roger Lamb
Publisher : Mit Press
Release : 1986
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"The editors have selected, updated and supplemented material from the original dictionary to provide in this and similar volumes a compact but compendious coverage of the most widely studied of these specialities." Contains over 250 entries covering abnormal behavior and the chemistry and neurophysiology of the nervous system. Lengthy entries. Index.

Introduction to Clinical Psychology

Introduction to Clinical Psychology Book
Author : Norman D. Sundberg,Julian R. Taplin,Leona Elizabeth Tyler
Publisher : Prentice Hall
Release : 1983
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Introduction to Clinical Psychology book written by Norman D. Sundberg,Julian R. Taplin,Leona Elizabeth Tyler, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Modulation of Multidrug Transporters a Potential Pharmacokinetic Mechanism of Clinical Drug drug Interactions

Modulation of Multidrug Transporters  a Potential Pharmacokinetic Mechanism of Clinical Drug drug Interactions Book
Author : Lingling Guan
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Modulation of Multidrug Transporters a Potential Pharmacokinetic Mechanism of Clinical Drug drug Interactions book written by Lingling Guan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Research Communications in Chemical Pathology and Pharmacology

Research Communications in Chemical Pathology and Pharmacology Book
Author : Anonim
Publisher : Unknown
Release : 1991-07
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Research Communications in Chemical Pathology and Pharmacology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Clinical Chemistry

Clinical Chemistry Book
Author : Lawrence A. Kaplan,Amadeo J. Pesce
Publisher : CRC Press
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Clinical Chemistry book written by Lawrence A. Kaplan,Amadeo J. Pesce, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Integrative Modeling of Mitochondrial Bioenergetics and Application to Clinical Diagnostics of Mitochondrial Disorders

Integrative Modeling of Mitochondrial Bioenergetics and Application to Clinical Diagnostics of Mitochondrial Disorders Book
Author : Ivan Chang
Publisher : Unknown
Release : 2011
ISBN : 9781267132031
Language : En, Es, Fr & De

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Book Description :

Mitochondrial bioenergetic processes are central to the production of cellular energy, and a decrease in the expression or activity of enzyme complexes responsible for these processes can result in energetic deficit that correlates with many metabolic diseases and aging. Unfortunately, existing computational models of mitochondrial bioenergetics either lack relevant kinetic descriptions of the enzyme complexes, or incorporate mechanisms too specific to a particular mitochondrial system and are thus incapable of capturing the heterogeneity associated with these complexes across different systems and system states. To this end, we introduce a new unifying modeling framework to describe the various energy transduction complexes in the mitochondrial oxidation-phosphorylation (OXPHOS) pathway. This modeling framework is based on an expanded set of conserved properties of a prototypical oxidoreductase complex, which can be used to produce either a macro kinetics model of the complex in the form of a general steady-state chemiosmotic rate law, or a micro kinetic model of the complex that consists of a system of elementary reactions within the complex. The steady-state chemiosmotic rate law is a function of: the saturation kinetics of the electron donor and acceptor substrates; the redox transfer potential between the complex and the substrates; and the steady-state thermodynamic force-to-flux relationship of the overall electro-chemical reaction. Modeling of bioenergetics with this rate law has several advantages over existing rate equations: (1) it minimizes the use of arbitrary free parameters while featuring biochemically relevant parameters that can be obtained through progress curves of common enzyme kinetics protocols; (2) it is modular and can adapt to various enzyme complex arrangements for both in vivo and in vitro systems via transformation of its rate and equilibrium constants; (3) it provides a clear association between the sensitivity of the parameters of the individual complexes and the sensitivity of the system's steady-state. The micro model produces a more complete deterministic description of the complex's kinetics such as the transient phase of the reaction by avoiding various steady-state approximations through explicitly accounting of the elementary reactions within the enzyme. In addition, it has the ability to regress, through a general-to-specific reduction of its elementary reactions, to many sub-models, some of which are equivalent with existing micro/macro models of oxidoreductase. Furthermore, it's elementary reactions can also be used in conjunction with Monte-Carlo probability density sampling technique such as Gillespie's stochastic simulation algorithm (SSA) to produce stochastic time-series, which would include the intrinsic variability of the catalyzed reaction. Since the two models are derived from the same framework, their results are shown to overlap exactly in the domain range shared by them. This has a dual benefit of allowing one to directly estimate the difficult to obtain unitary rate constants of the micro model from the readily obtained steady-state kinetic parameters of the macro model, and in reverse allowing one to ascribe stochastic variability to the steady-state chemiosmotic equation. Thus, by combing the two complementary modeling regimes, the usefulness of each one is greatly enhanced.

Annual Report

Annual Report Book
Author : Robert A. Welch Foundation
Publisher : Unknown
Release : 1970
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Annual Report book written by Robert A. Welch Foundation, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Medical Research Council Handbook

Medical Research Council Handbook Book
Author : Medical Research Council (Great Britain)
Publisher : Unknown
Release : 1991
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Continues the Reference section included in previous annual reports, and gives details of the activities of Council establishments and of the other forms of research sponsored by the Council.

Directory of Pathology Training Programs

Directory of Pathology Training Programs Book
Author : Anonim
Publisher : Unknown
Release : 1984
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Describes training facilities, residencies, remuneration, application requirements, and faculty at approved programs for anatomic and clinical pathology in the U.S. and Canada. Also includes coverage of fellowships and postgraduate opportunities for training.

New Serial Titles

New Serial Titles Book
Author : Anonim
Publisher : Unknown
Release : 1991
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A union list of serials commencing publication after Dec. 31, 1949.