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Clinical And Translational Science

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Clinical and Translational Science

Clinical and Translational Science Book
Author : David Robertson
Publisher : Academic Press
Release : 2016-10-17
ISBN : 9780128021019
Language : En, Es, Fr & De

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Book Description :

"Clinical and Translational Science: Principles of Human Research, Second Edition, " is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicineBrings insights from international leaders into the discipline of clinical and translational scienceAddresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Clinical and Translational Science

Clinical and Translational Science Book
Author : David Robertson,Gordon H. Williams
Publisher : Academic Press
Release : 2009-03-02
ISBN : 9780080920191
Language : En, Es, Fr & De

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Book Description :

Clinical or translational science is the field of study devoted to investigating human health and disease, interventions and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of human disease and the application of new therapeutics for enhanced health. Clinical and Translational Science is designed as the most authoritative and modern resource for the broad range of investigators in various medical specialties taking on the challenge of clinical research. Prepared with an international perspective, this resource begins with experimental design and investigative tools to set the scene for readers. It then moves on to human genetics and pharmacology with a focus on statistics, epidemiology, genomic information, drug discovery and development, and clinical trials. Finally, it turns to legal, social, and ethical issues of clinical research concluding with a discussion of future prospects to provide readers with a comprehensive view of the this developing area of science. Clinical research is one of the fastest growing fields in private practice and academic medicine with practical biological, physiological, cellular, and therapeutic applications Contributions from international leaders provide insight into background and future understanding for clinical and translational science Provides the structure for complete instruction and guidance on the subject from fundamental principles, approaches and infrastructure to human genetics, human pharmacology, research in special populations, the societal context of human research, and the future of human research

The CTSA Program at NIH

The CTSA Program at NIH Book
Author : Institute of Medicine,Board on Health Sciences Policy,Committee to Review the Clinical and Translational Science Awards Program at the National Center for Advancing Translational Sciences
Publisher : National Academies Press
Release : 2013-10-09
ISBN : 0309284740
Language : En, Es, Fr & De

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Book Description :

In 2006 the National Institutes of Health (NIH) established the Clinical and Translational Science Awards (CTSA) Program, recognizing the need for a new impetus to encourage clinical and translational research. At the time it was very difficult to translate basic and clinical research into clinical and community practice; making it difficult for individual patients and communities to receive its benefits. Since its creation the CTSA Program has expanded, with 61 sites spread across the nation's academic health centers and other institutions, hoping to provide catalysts and test beds for policies and practices that can benefit clinical and translation research organizations throughout the country. The NIH contracted with the Institute of Medicine (IOM) in 2012 to conduct a study to assess and provide recommendations on appropriateness of the CTSA Program's mission and strategic goals and whether changes were needed. The study was also address the implementation of the program by the National Center for Advancing Translational Sciences (NCATS) while exploring the CTSA's contributions in the acceleration of the development of new therapeutics. A 13-member committee was established to head this task; the committee had collective expertise in community outreach and engagement, public health and health policy, bioethics, education and training, pharmaceutical research and development, program evaluation, clinical and biomedical research, and child health research. The CTSA Program at NIH: Opportunities for Advancing Clinical and Translational Research is the result of investigations into previous program evaluations and assessments, open-session meetings and conference class, and the review of scientific literature. Overall, the committee believes that the CTSA Program is significant to the advancement of clinical and translational research through its contributions. The Program would benefit from a variety of revisions, however, to make it more efficient and effective.

Principles of Translational Science in Medicine

Principles of Translational Science in Medicine Book
Author : Martin Wehling
Publisher : Academic Press
Release : 2015-04-02
ISBN : 0128007214
Language : En, Es, Fr & De

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Book Description :

Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies Details IPR issues of translation, especially for public-private-partnerships Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions

Clinical and Translational Science in Sport Rehabilitation

Clinical and Translational Science in Sport Rehabilitation Book
Author : Mark A. Merrick,Michael G. Dolan
Publisher : Unknown
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Clinical and Translational Science in Sport Rehabilitation book written by Mark A. Merrick,Michael G. Dolan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Integrating Clinical and Translational Research Networks Building Team Medicine

Integrating Clinical and Translational Research Networks   Building Team Medicine Book
Author : Ravi Salgia,Prakash Kulkarni
Publisher : MDPI
Release : 2021-01-29
ISBN : 303650396X
Language : En, Es, Fr & De

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Book Description :

Medical centers are widely recognized as vital components of the healthcare system. However, academic medical centers are differentiated from their community counterparts by their mission, which typically focuses on clinical care, education, and research. Nonetheless, community clinics/hospitals fill a critical need and play a complementary role serving as the primary sites for health care in most communities. Furthermore, it is now increasingly recognized that in addition to physicians, physician-scientists, and other healthcare-related professionals, basic research scientists also contribute significantly to the emerging inter- and cross-disciplinary, team-oriented culture of translational science. Therefore, approaches that combine the knowledge, skills, experience, expertise, and visions of clinicians in academic medical centers and their affiliated community centers and hospitals, together with basic research scientists, are critical in shaping the emerging culture of translational research so that patients from the urban as well as suburban settings can avail the benefits of the latest developments in science and medicine. ‘Integrating Clinical and Translational Research Networks—Building Team Medicine’ is an embodiment of this ethos at the City of Hope National Medical Center in Duarte, California. It includes a series of papers authored by teams of leading clinicians, basic research scientists, and translational researchers. The authors discuss how engaging and collaborating with community-based practices, where the majority of older patients with cancer receive their care, can ensure that these patients receive the highest-quality, evidence-based care. Based on our collective experience at City of Hope, we would like to stress that the success of academic-community collaborative programs not only depends on the goodwill and vision of the participants but also on the medical administration, academic leadership, and policymakers who define the principles and rules by which cooperation within the health care industry occurs. We trust that our experience embodied in this singular compendium will serve as a ‘Rosetta Stone’ for other institutions and practitioners.

NIH Administration of the Clinical and Translational Science Awards Program

NIH Administration of the Clinical and Translational Science Awards Program Book
Author : United States. Department of Health and Human Services. Office of Inspector General
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download NIH Administration of the Clinical and Translational Science Awards Program book written by United States. Department of Health and Human Services. Office of Inspector General, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Translational Medicine

Translational Medicine Book
Author : James Mittra,Christopher-Paul Milne
Publisher : CRC Press
Release : 2016-04-19
ISBN : 9814364843
Language : En, Es, Fr & De

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Book Description :

This book brings together a range of academic, industry and practitioner perspectives on translational medicine (TM). It enhances conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure. In recognition of the various implications TM has for public health policy and commercial innovation, the book addresses the major systemic aspects of the field. The contributors explore the dynamic interactions and key challenges in translating new science into viable therapies for the clinic, which includes recognizing the importance of social, commercial, and regulatory environments in addition to good science.

Progress in Molecular Biology and Translational Science

Progress in Molecular Biology and Translational Science Book
Author : Anonim
Publisher : Academic Press
Release : 2019-03-22
ISBN : 012817739X
Language : En, Es, Fr & De

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Book Description :

Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part A, Volume 162 in the Progress in Molecular Biology and Translational Science series provides informative monographs on a variety of research topics related to Glycans and glycosaminoglycans as clinical biomarkers and therapeutics. Topics in this update include Glycan-based Biomarkers for Diagnosis of Cancers and Other Diseases: Past, Present and Future, Desialylation in Diseases and its Application in Diagnostic and Therapeutic Development, Proteoglycans as Miscommunication Biomarkers for Cancer Diagnosis, Fucosylation in Cancer Biology and Its Clinical Applications, Retrospective Analysis of Glycan-Related Biomarkers Based on Clinical Laboratory Data in Two Medical Centers, and many related topics. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

CTSA Program at NIH

CTSA Program at NIH Book
Author : Anonim
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download CTSA Program at NIH book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cures vs Profits

Cures vs  Profits Book
Author : James Lyons-Weiler
Publisher : World Scientific
Release : 2016-03-28
ISBN : 9814730165
Language : En, Es, Fr & De

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Book Description :

Did you ever wonder whether doctors want cures, or just treatments? Did you know ... Grapefruit can interact with over 100 drugs, but it may be useful for reducing blood pressure and for weight loss?ADHD over diagnosis is now recognized widely as a fact, and there are existing — and new ways — to avoid a misdiagnosis?Studies have been conducted demonstrating the utility of Omega 3 fatty acids, meditation, yoga, and melatonin for some important symptoms of ADHD, including executive functions?Vaccines have saved millions of lives in the last decade? But are they safe?Breast cancer rates are declining in the US, but have been steadily increasing in Japan?Doctors are getting better at predicting which chemotherapy will, and will not work, on certain cancers?There are vaccines against cancer? This book reviews recent key, hard-won successes and findings from recent biomedical research. Written by one of the most ardent defenders of the public trust in science, it provides an accessible, detailed look at successes in translational biomedical and clinical research. The author provides an optimistic, forward-looking view for the possibility of change for the public good, cutting through the controversy and gets to very core of each topic. The public can be optimistic about the future of medicine, but only if they learn the facts of these advances, and learn what their doctors should be expected to know. Highly referenced, and filled with interviews from experts and people directly involved in the research behind the new facts in each chapter, this book is a rich source of information on advances in biomedicine that you will want to share with your family & friends. Contents: PrefaceAbuses in MedicineOutrageous Acts of PseudoscienceWait ... Grapefruit is Bad for You?Hormone Receptor Status and Breast Cancer TreatmentFecal Microbiota TransplantationOverdiagnosis of ADHD: It's Their Mind, Not YoursVaccination Programs: Eradication of Infectious DiseasesChemosensitivity and Chemoresistance Assays in CancerA Very Special Kind of Brain Cancer SurgeryGenomics and Personalized MedicineRobot-Assisted SurgeryHallmarks and Principles of Translational Research SuccessFuture Medicine 1: Early Detection and Cures for Alzheimer's DiseaseFuture Medicine 2: Cancer VaccinesThe Future of Translational Research Readership: Lay public, scientists, doctors, politicians, policy makers, public health workers, health care worker, investors.

Studyguide for Clinical and Translational Science

Studyguide for Clinical and Translational Science Book
Author : Cram101 Textbook Reviews
Publisher : Cram101
Release : 2013-05
ISBN : 9781490239613
Language : En, Es, Fr & De

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Book Description :

Never HIGHLIGHT a Book Again Virtually all testable terms, concepts, persons, places, and events are included. Cram101 Textbook Outlines gives all of the outlines, highlights, notes for your textbook with optional online practice tests. Only Cram101 Outlines are Textbook Specific. Cram101 is NOT the Textbook. Accompanys: 9780521673761

Nanoparticles in Translational Science and Medicine

Nanoparticles in Translational Science and Medicine Book
Author : Antonio Villaverde
Publisher : Academic Press
Release : 2011
ISBN : 0124160204
Language : En, Es, Fr & De

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Book Description :

This volume explores some of the most exciting recent advances in basic research on nanoparticles in translational science and medicine and how this knowledge is leading to advances in the various fields. This series provides a forum for discussion of new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields

2017 Pathways to Cures Clinical and Translational Science Day at UCI

2017 Pathways to Cures  Clinical and Translational Science Day at UCI Book
Author : Institute for Clinical and Translational Science
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download 2017 Pathways to Cures Clinical and Translational Science Day at UCI book written by Institute for Clinical and Translational Science, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Translational Informatics

Translational Informatics Book
Author : Philip R.O. Payne,Peter J. Embi
Publisher : Springer
Release : 2014-08-23
ISBN : 1447146468
Language : En, Es, Fr & De

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Book Description :

Integrative and translational methodologies and frameworks have transformed modern biomedical research and the delivery of clinical care. This shift has been manifested in a number of ways, including the rapid growth and increasing availability of high-throughput bio-molecular instrumentation and analysis platforms, innovative clinical research programs intended to accelerate knowledge translation, and initial efforts to deliver personalized healthcare informed by the genomic profiles of patients. A common theme of reports and publications concerned with such transformative changes in the biomedical and healthcare domains is concerned with the challenges and opportunities related to the collection, management, integration, analysis, and dissemination of large-scale, heterogeneous biomedical data sets. In particular, the absence of well-established and adopted theoretical and practical frameworks intended to address such needs is a major impediment to the realization of translational and knowledge-driven healthcare, in which the best possible scientific evidence is used to inform the care of every patient. In this vacuum, the development of integrative clinical or translational research paradigms is significantly limited by the propagation of both data and expertise silos. This book details for the first time the current state of this extremely potent area of healthcare innovation and policy and defines the interaction between clinical/translational science and biomedical informatics.​

2016 Pathways to Cures Clinical and Translational Science Day at UCI

2016 Pathways to Cures  Clinical and Translational Science Day at UCI Book
Author : Institute for Clinical and Translational Science
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download 2016 Pathways to Cures Clinical and Translational Science Day at UCI book written by Institute for Clinical and Translational Science, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

2015 Pathways to Cures Clinical and Translational Science Day at UCI

2015 Pathways to Cures  Clinical and Translational Science Day at UCI Book
Author : Institute for Clinical and Translational Science
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download 2015 Pathways to Cures Clinical and Translational Science Day at UCI book written by Institute for Clinical and Translational Science, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

2014 Pathways to Cures Clinical and Translational Science Day at UCI

2014 Pathways to Cures  Clinical and Translational Science Day at UCI Book
Author : Institute for Clinical and Translational Science
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download 2014 Pathways to Cures Clinical and Translational Science Day at UCI book written by Institute for Clinical and Translational Science, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Designing Biomedical Informatics Infrastructure for Clinical and Translational Science

Designing Biomedical Informatics Infrastructure for Clinical and Translational Science Book
Author : Ariel Isaac La Paz Lillo
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Designing Biomedical Informatics Infrastructure for Clinical and Translational Science book written by Ariel Isaac La Paz Lillo, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.