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Clinical And Translational Perspectives On Wilson Disease

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Clinical and Translational Perspectives on WILSON DISEASE

Clinical and Translational Perspectives on WILSON DISEASE Book
Author : Nanda Kerkar,Eve A Roberts
Publisher : Academic Press
Release : 2018-09-18
ISBN : 012810533X
Language : En, Es, Fr & De

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Book Description :

Clinical and Translational Perspectives on Wilson Disease brings together the genetics, cell and structural biology of Wilson Disease into one contemporary, easy to navigate handbook. Created to meet the diverse needs of the clinical and research communities surrounding Wilson Disease, this reference provides a worldwide approach that is concise and translational. Specifically, it provides a basis for clinicians to appreciate ‘basic science’ aspects of Wilson disease, presenting a guide for researchers to understand the clinical disorder on which their research is focused and fostering constructive dialogue and progress for this puzzling disorder. Delivers numerous, succinct, expert chapters with summaries designed for quick reference Includes a 'How-to appendix' for diagnosis and management tips Contains access to a companion website with a self-help teaching module, links to key resources, and an extended reference list

Cu RE Your Fatigue The Root Cause and How To Fix It On Your Own

Cu RE Your Fatigue  The Root Cause and How To Fix It On Your Own Book
Author : Morley Robbins
Publisher : Gatekeeper Press
Release : 2021-11-01
ISBN : 1662910290
Language : En, Es, Fr & De

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Book Description :

The leading cause of death on Planet Earth is Metabolic Syndrome. Some 40% of all Earthlings now suffer from this condition which covers the gamut of Heart Disease, Cancer, Neurodegeneration, Liver disease, and PCOS. What is worth knowing is that ALL of these and related conditions start with Fatigue, known in scientific circles as "energy deficiency." 40% of the Earth's population has a formal clinical diagnosis that their mitochondria cannot make adequate levels of energy. [Cu]re Fatigue is a book devoted to educating the masses and their doctors exactly how and why this is happening. Our mitochondria make energy by a series of enzymes to work synergistically to create ATP, the cellular currency of energy. These mitochondrial enzyme reactions rely on minerals that are easily lost to stress. This book explains these concepts, how these challenges can be overcome and introduces the reader to a simple, proven Root Cause Protocol that is designed to generate more energy and end fatigue. This book is designed for those seeking the truth in human metabolism and those wanting to take back control of their health. It is one part textbook and one part user's guide based on a decade of research and client experience.

Chemistry and Biochemistry of Food

Chemistry and Biochemistry of Food Book
Author : Jose Perez-Castineira
Publisher : Walter de Gruyter GmbH & Co KG
Release : 2020-09-07
ISBN : 3110595486
Language : En, Es, Fr & De

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Book Description :

This book provides an excellent platform for understanding the chemical processes involved in food transformation. Starting with the examination of major food components, such as water, carbohydrates, lipids, proteins and minerals, the author further introduces the biochemistry of digestion and energy metabolism of food ingredients. The last section of the book is devoted to modern food technologies and their future perspectives.

Liver Disease in Children

Liver Disease in Children Book
Author : Frederick J. Suchy,Ronald J. Sokol,William F. Balistreri,Jorge A. Bezerra,Cara L. Mack,Benjamin L. Shneider
Publisher : Cambridge University Press
Release : 2021-03-18
ISBN : 1108911374
Language : En, Es, Fr & De

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Book Description :

Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.

Toxicology

Toxicology Book
Author : Vinood B. Patel,Victor R. Preedy
Publisher : Academic Press
Release : 2020-11-20
ISBN : 0128190930
Language : En, Es, Fr & De

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Book Description :

Toxicology: Oxidative Stress and Dietary Antioxidants examines the nature of oxidative stress as a consequence of exposure to toxins and how antioxidant approaches can mitigate the impact of toxicant exposures. Sections covers the basic biology of oxidative stress, from molecular biology, to physiological pathology, mechanisms of action of specific toxicants, metals and other chemicals/drugs, and antioxidant approaches and therapies for toxic exposures. With contributions from an international group of experts, useful summary sections, a dictionary of terms, and applications to other areas of toxicology, this book is an informative, consolidated reference that helps bridge the interrelationship between toxicology, oxidative stress and antioxidants. Provides a novel collection of information linking both sides of redox biology (oxidants and antioxidants) and toxicology Explores the role of free radical mediated damage and toxicology Contains contributions from experts on toxicological science surrounding oxidative stress and on antioxidant approaches for reducing the impact of toxicant exposures

Wilson Disease

Wilson Disease Book
Author : Karl Heinz Weiss,Michael Schilsky
Publisher : Academic Press
Release : 2019-05-21
ISBN : 0128110783
Language : En, Es, Fr & De

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Book Description :

Wilson Disease: Pathogenesis, Molecular Mechanisms, Diagnosis, Treatment and Monitoring translates both clinical and experimental findings into a comprehensive approach for anyone involved in research and patient care. While the clinical variability of Wilson Disease poses a challenge from a diagnostic approach, the book uses the translational impact of new research findings to relate to new treatment concepts. Comprehensive chapters include common knowledge, guideline consensus statements, and discussions of clinical evidence. This is a must-have reference for researchers and clinicians in translational research. Delivers a substantial overview of evidence driven diagnostic pathways and treatment concepts for Wilson disease Provides an understanding of the translational impact of new research findings in Wilson Disease Reveals the current controversies in treatment decisions for Wilson disease, providing the best decisions for optimal patient care

Applied Nuclear Physics at Accelerators

Applied Nuclear Physics at Accelerators Book
Author : Marco Durante,Vincenzo Patera,Yolanda Prezado
Publisher : Frontiers Media SA
Release : 2021-07-14
ISBN : 2889710394
Language : En, Es, Fr & De

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Book Description :

Download Applied Nuclear Physics at Accelerators book written by Marco Durante,Vincenzo Patera,Yolanda Prezado, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Bioremediation for Environmental Sustainability

Bioremediation for Environmental Sustainability Book
Author : Vineet Kumar,Gaurav Saxena,Maulin P. Shah
Publisher : Elsevier
Release : 2020-08-28
ISBN : 012820317X
Language : En, Es, Fr & De

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Book Description :

Bioremediation for Environmental Sustainability: Approaches to Tackle Pollution for Cleaner and Greener Society discusses many recently developed and successfully applied bio/phytoremediation technologies for pollution control and minimization, which are lacking more comprehensive coverage in previous books. This book describes the scope and applications of bio/phytoremediation technologies and especially focuses on the associated eco-environmental concerns, field studies, sustainability issues, and future prospects. The book also examines the feasibility of environmentally friendly and sustainable bio/phytoremediation technologies to remediate contaminated sites, as well as future directions in the field of bioremediation for environmental sustainability. Illustrates the importance of microbes and plants in bio/phytoremediation and wastewater treatment Includes chapters on original research outcomes pertaining to pollution, pollution abatement, and associated bioremediation technologies Covers emerging bioremediation technologies, including electro-bioremediation, microbial fuel cell, nano-bioremediation, constructed wetlands, and more Highlights key developments and challenges in bioremediation and phytoremediation technologies Describes the roles of relatively new approaches in bio/phytoremediation, including molecular engineering and omics technologies, microbial enzymes, biosurfactants, plant-microbe interactions, genetically engineered organisms, and more

Water Chemistry

Water Chemistry Book
Author : Murat Eyvaz,Ebubekir Yüksel
Publisher : BoD – Books on Demand
Release : 2020-02-05
ISBN : 1789855578
Language : En, Es, Fr & De

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Book Description :

Water, which plays an important role in every aspect of our daily lives, is the most valuable natural resource we have on this planet. Drinking, bathing, cooking, regeneration, cleaning, production, energy, and many other uses of water originate from some of its versatile, useful, basic, and unique features. The access, purification, and reuse of water on our planet, which is of course not endless and not available for direct use, is directly related to the water chemistry that explores its inimitable properties. This book includes research on water chemistry-related applications in environmental management and sustainable environmental issues such as water and wastewater treatment, water quality management, and other similar topics. The book consists of three sections, namely, water treatment, wastewater treatment, and water splitting, respectively, and includes 11 chapters. In these chapters, water-wastewater remediation methods, nanomaterials in water treatment, and water splitting processes are comprehensively reviewed in terms of water chemistry.The editors would like to record their sincere thanks to the authors for their contributions.

Platelets in Thrombotic and Non Thrombotic Disorders

Platelets in Thrombotic and Non Thrombotic Disorders Book
Author : Paolo Gresele,Neal S. Kleiman,José A. Lopez,Clive P. Page
Publisher : Springer
Release : 2017-03-08
ISBN : 3319474626
Language : En, Es, Fr & De

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Book Description :

This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.

Liver Immunology

Liver Immunology Book
Author : M. Eric Gershwin,John M. Vierling,Atsushi Tanaka,Michael P. Manns
Publisher : Springer Nature
Release : 2020-11-03
ISBN : 3030517098
Language : En, Es, Fr & De

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Book Description :

The third edition of this acclaimed work provides clinicians and investigators with a wealth of state-of-the-art information that will lead to fresh approaches in thinking about liver physiology and liver diseases. Developed by a panel of renowned international authors, this edition outlines a range of important advances in our understanding of the liver’s role as an immune organ and the functions of innate and adaptive immunity in the pathogenesis of all liver diseases. Indeed, the liver is a vitally important immune organ producing liver-derived products that can trigger the innate and adaptive immune system to initiate, mediate, regulate, and resolve systemic inflammation. The book begins with an analysis of the core concepts of immunology, including the definition of autoimmunity and its unique application to the liver, a tolerogenic organ. Subsequent chapters then explore the biological elements of liver diseases caused by epigenetics, genetics, and innate and adaptive immunity. Specific clinical presentations and aspects of liver diseases are also examined, such as Hepatitis C, non-alcoholic fatty liver disease and parasitic infections. Closing chapters then discuss liver diseases among specific populations, including pediatrics, those with comorbidities and preexisting conditions, pregnant women, and finally patients with transplanted organs. A timely and invaluable update to the clinical literature, Liver Immunology: Principles and Practice, Third Edition, is once again a comprehensive work that will not only enhance the understanding of liver diseases but also provide the kind of novel insights that greatly accelerates the evidence-based care of children and adults afflicted with these diseases. This volume is again a must-read for clinicians at all levels, for investigators and for students.

Translational Perspectives in Auditory Neuroscience

Translational Perspectives in Auditory Neuroscience Book
Author : Kelly L.Tremblay,Robert F. Burkard
Publisher : Plural Publishing
Release : 2012-06-29
ISBN : 1597566888
Language : En, Es, Fr & De

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Book Description :

Download Translational Perspectives in Auditory Neuroscience book written by Kelly L.Tremblay,Robert F. Burkard, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Clinical and Translational Science

Clinical and Translational Science Book
Author : David Robertson,Gordon H. Williams
Publisher : Academic Press
Release : 2016-11-25
ISBN : 012802111X
Language : En, Es, Fr & De

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Book Description :

Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Balancing Act Structural Functional Circuit Disruptions and Compensations in Developing and Aging Brain Disorders

Balancing Act  Structural Functional Circuit Disruptions and Compensations in Developing and Aging Brain Disorders Book
Author : Lijun Bai,Tuo Zhang,Xi-Nian Zuo,Mingzhou Ding
Publisher : Frontiers Media SA
Release : 2020-02-20
ISBN : 2889634868
Language : En, Es, Fr & De

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Book Description :

Download Balancing Act Structural Functional Circuit Disruptions and Compensations in Developing and Aging Brain Disorders book written by Lijun Bai,Tuo Zhang,Xi-Nian Zuo,Mingzhou Ding, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Translational Neurosonology

Translational Neurosonology Book
Author : A. Alonso,M.G. Hennerici,S. Meairs
Publisher : Karger Medical and Scientific Publishers
Release : 2014-12-16
ISBN : 331802791X
Language : En, Es, Fr & De

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Book Description :

Diagnostic ultrasound has become an elementary tool for evaluating cerebrovascular diseases and plays a prominent role in routine clinical practice. Many publications attempt to cover the continuous progress of its diagnostic and even therapeutic applications. However, the impact ultrasound has made in recent years in the fields of animal studies and human research is less well known. This publication provides an overview on exciting current attempts in neurological diseases, ranging from experimental approaches to established imaging modes ready to be incorporated into the routine of daily practice. The first part of the book concentrates on basic principles of neurosonology and focuses on contrast imaging, specific ultrasound contrast agents and safety aspects. The following chapters deal with different vascular ultrasound applications, allowing an optimized characterization of atherosclerotic disease and monitoring of cerebral autoregulation. In addition, the role of parenchymal ultrasound imaging in cerebrovascular diseases and movement disorders is illustrated. The final chapters look at promising new therapeutic approaches implementing ultrasound although they are still no more than experimental. The book can be highly recommended to clinical neurologists with good knowledge in clinical ultrasound who wish to gain a compact and updated insight into the plethora of capabilities of neurosonology in the future.

Bradley s Neurology in Clinical Practice E Book

Bradley s Neurology in Clinical Practice E Book Book
Author : Joseph Jankovic,John C. Mazziotta,Scott L Pomeroy
Publisher : Elsevier Health Sciences
Release : 2021-03-23
ISBN : 0323642624
Language : En, Es, Fr & De

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Book Description :

A practical, dynamic resource for practicing neurologists, clinicians and trainees, Bradley and Daroff's Neurology in Clinical Practice, Eighth Edition, offers a straightforward style, evidence-based information, and robust interactive content supplemented by treatment algorithms and images to keep you up to date with all that’s current in this fast-changing field. This two-volume set is ideal for daily reference, featuring a unique organization by presenting symptom/sign and by specific disease entities—allowing you to access content in ways that mirror how you practice. More than 150 expert contributors, led by Drs. Joseph Jankovic, John C. Mazziotta, Scott L. Pomeroy, and Nancy J. Newman, provide up-to-date guidance that equips you to effectively diagnose and manage the full range of neurological disorders. Covers all aspects of today’s neurology in an easy-to-read, clinically relevant manner. Allows for easy searches through an intuitive organization by both symptom and grouping of diseases. Features new and expanded content on movement disorders, genetic and immunologic disorders, tropical neurology, neuro-ophthalmology and neuro-otology, palliative care, pediatric neurology, and new and emerging therapies. Offers even more detailed videos that depict how neurological disorders manifest, including EEG and seizures, deep brain stimulation for PD and tremor, sleep disorders, movement disorders, ocular oscillations, EMG evaluation, cranial neuropathies, and disorders of upper and lower motor neurons, as well as other neurologic signs.

The Alzheimer s Disease Challenge

The Alzheimer s Disease Challenge Book
Author : Athanasios Alexiou,Mohammad A. Kamal,Ghulam Md Ashraf
Publisher : Frontiers Media SA
Release : 2019-12-04
ISBN : 2889631281
Language : En, Es, Fr & De

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Book Description :

Alzheimer’s disease is undoubtedly the major health challenge of our Century with significant social and economic consequences. This Frontiers eBook offers a contribution of 39 innovative papers on the multidimensional and crucial problem of Alzheimer’s disease management and treatment. Several perspectives, research updates, and trials describing methods on potential diagnosis and treatment are presented including biological mechanisms, biomarkers and risk factors for an early and efficient prognosis, diagnosis and prevention. Additionally, while the rapidly increasing Alzheimer’s disease population demands holistic solutions and clinical studies with new therapeutic target approaches, several of the contributive papers present promising drugs targeting Alzheimer’s disease treatment. We give our deepest acknowledgment to all the authors for their important and innovative contributions, to the reviewers for their valuable recommendations on improving the submitting studies and all the Frontiers Editorial team for continuous support.

Translational Neuroimaging

Translational Neuroimaging Book
Author : Robert A. McArthur
Publisher : Academic Press
Release : 2012-10-05
ISBN : 0123869978
Language : En, Es, Fr & De

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Book Description :

Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. The focus of this book is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field. Provides a background to translational research and the use of brain imaging in neuropsychiatric disorders Critical discussion of the potential and limitations of neuroimaging as a translational tool for identifying and validating biomarkers Identifies cross species neurosystems and common endpoints necessary to help accelerate CNS drug discovery and development for the treatment of neuropsychiatric disorders Features an accompanying website with additional images and text

Family Resilience and Chronic Illness

Family Resilience and Chronic Illness Book
Author : Ginger L. Welch,Amanda W. Harrist
Publisher : Springer
Release : 2016-07-29
ISBN : 3319260332
Language : En, Es, Fr & De

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Book Description :

This interdisciplinary volume offers theoretical, empirical, and practical insights into the strengths of families beset by chronic health issues. Featuring topics that run the lifespan from infancy to late adulthood, its coverage reflects both the diversity of family challenges in long-term illness and the wealth of effective approaches to intervention. The component skills of resilience in life-changing circumstances, from coping and meaning making to balancing care and self-care, are on rich display in a framework for their enhancement in therapy. The book’s expert contributors include tools to aid readers in the learning and teaching of concepts as they model respectful, meaningful research methods and ethical, non-judgmental practice. Among the topics covered: Helping families survive and thrive through the premature birth of an infant. Enhancing coping and resiliency among families of individuals with sickle cell disease. A family science approach to pediatric obesity treatment. Risk and resilience of children and families involved with the foster care system. Strengthening families facing breast cancer: emerging trends and clinical recommendations. The unfolding of unique problems in later life families. With its mix of practical and empirical expertise, Family Resilience and Chronic Illness: Interdisciplinary and Translational Perspectives has much to offer both researchers in the family resilience field and mental health practitioners working with clients with chronic illness.

Sperling Pediatric Endocrinology E Book

Sperling Pediatric Endocrinology E Book Book
Author : Mark A. Sperling
Publisher : Elsevier Health Sciences
Release : 2020-07-22
ISBN : 0323625215
Language : En, Es, Fr & De

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Book Description :

An ideal resource for both pediatricians and endocrinologists, Sperling’s Pediatric Endocrinology, 5th Edition, brings you fully up to date with accelerating research; new discoveries in metabolic, biochemical and molecular mechanisms; and the resulting advances in today’s clinical care. The editorial team of world-renowned pediatric endocrinologists led by Dr. Mark Sperling, as well as expert contributing authors, cover comprehensive and current aspects of both basic science and clinical practice. Whether you’re preparing for certification or have extensive clinical experience, this detailed, authoritative reference helps you increase your knowledge and determine the best possible course for every patient. Delivers trusted guidance in every area of the field: including Endocrine Disorders of the Newborn, Endocrine Disorders of Childhood and Adolescence, and Laboratory Tests. Features new topics such as transgender issues in children and adolescents and endocrinology of pregnancy, the fetus and the placenta. Offers expert coverage of hot topics such as disorders of sexual development, molecular basis of endocrine disorders, hypoglycemia in newborns and infants; neonatal and other monogenic forms of diabetes; Type I and Type II diabetes and their treatment with new insulins together with the progress in an artificial pancreas and new medications for T2DM in adolescents; the obesity epidemic and role of bariatric surgery; and advances toward personalized medicine. Includes easy-to-follow algorithms and numerous quick-reference tables and boxes in every clinical chapter, plus interactive questions online for self-assessment. Offers state-of-the-art information and fresh perspectives from new and award-winning authors in such areas as disorders of growth, multiple endocrine tumors, and puberty and its disorders in girls and boys.