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Chromatin Readers In Health And Disease

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Environmental Epigenomics in Health and Disease

Environmental Epigenomics in Health and Disease Book
Author : Randy L Jirtle,Frederick L. Tyson
Publisher : Springer Science & Business Media
Release : 2013-05-16
ISBN : 3642233805
Language : En, Es, Fr & De

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Book Description :

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.

Epigenomics in Health and Disease

Epigenomics in Health and Disease Book
Author : Mario Fraga,Agustin Fernandez Fernandez
Publisher : Academic Press
Release : 2015-10-12
ISBN : 0128004967
Language : En, Es, Fr & De

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Book Description :

Epigenomics in Health and Disease discusses the next generation sequencing technologies shaping our current knowledge with regards to the role of epigenetics in normal development, aging, and disease. It includes the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells. With coverage pertinent to both basic biology and translational research, the book will be of particular interest for medical and bioscience researchers and students seeking current translational knowledge in epigenesis and epigenomics. Coverage includes the latest findings on epigenome-wide research in disease-based profiling, epidemiological implications, epigenome-wide epigenetic studies, the cancer epigenome, and other pervasive disease categories. Presents critical reviews that provide the means for reviewing and analyzing the epigenome as a whole, also discussing its translational potential Combines basic epigenomic knowledge with methodological and biostatistical topics related to technology and data analysis Includes coverage of relatively new topics, including DNA methylation dynamics during development and differentiation, genome-wide histone post-translational modifications during development and differentiation, and genome-wide DNA methylation changes during aging

Myeloid Cells in Health and Disease

Myeloid Cells in Health and Disease Book
Author : Siamon Gordon
Publisher : John Wiley & Sons
Release : 2020-07-10
ISBN : 1555819192
Language : En, Es, Fr & De

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Book Description :

The structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells. In Myeloid Cells in Health and Disease: A Synthesis, Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich, Elie Metchnikoff, and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells, including macrophage differentiation; and antigen processing and presentation. The rest of the book is organized by broad topics in immunology, including the recruitment of myeloid and other immune cells following microbial infection the role of myeloid cells in the inflammation process and the repair of damaged tissue the vast arsenal of myeloid cell secretory molecules, including metalloproteinases, tumor necrosis factor, histamine, and perforin receptors and downstream signaling pathways that are activated following ligand-receptor binding roles of myeloid cells during microbial and parasite infections contributions of myeloid cells in atherosclerosis myeloid-derived suppressor cells in tumor development and cancer Myeloid Cells in Health and Disease: A Synthesis will benefit graduate students and researchers in immunology, hematology, microbial pathogenesis, infectious disease, pathology, and pharmacology. Established scientists and physicians in these and related fields will enjoy the book's rich history of myeloid cell research and suggestions for future research directions and potential therapies.

Transcriptional Gene Regulation in Health and Disease

Transcriptional Gene Regulation in Health and Disease Book
Author : Anonim
Publisher : Academic Press
Release : 2018-01-15
ISBN : 0128123400
Language : En, Es, Fr & De

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Book Description :

Transcriptional Gene Regulation in Health and Disease, Volume 335, the latest release in the International Review of Cell and Molecular Biology reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of nine years. This great resource ranks high amongst scientific journals dealing with cell biology. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists drawn from international sources Offers a wide range of perspectives on specific subjects

Cellular Signaling in Health and Disease

Cellular Signaling in Health and Disease Book
Author : Martin Beckerman
Publisher : Springer Science & Business Media
Release : 2009-05-28
ISBN : 9780387981734
Language : En, Es, Fr & De

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Book Description :

In today’s world, three great classes of non-infectious diseases – the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders – have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling web operates properly in health and improperly in disease. The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional details integrated into the chapters dealing directly with the diseases. The connections responsible for maintaining stability are explored in depth.

Epigenetics in Health and Disease

Epigenetics in Health and Disease Book
Author : Igor Kovalchuk,Olga Kovalchuk
Publisher : FT Press
Release : 2012
ISBN : 013259708X
Language : En, Es, Fr & De

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Book Description :

"After reviewing the field's history and context, the authors introduce and explain each key epigenetic mechanism. Next, they extensively discuss the roles these mechanisms may play in inheritance, development, health and disease, behavior, evolution, ecology, and the interactions of individual organisms with their environments"--Cover, p. [4].

Individual and Community Health

Individual and Community Health Book
Author : William Whitfield Stiles
Publisher : Unknown
Release : 1953
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Individual and Community Health book written by William Whitfield Stiles, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Cell in Health and Disease

The Cell in Health and Disease Book
Author : John Kingsbury Frost
Publisher : S Karger Ag
Release : 1986
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A Karger 'Publishing Highlights 1890-2015' title Written by one of the founders of the field and eminent teachers of cytopathology, this timely monograph became an instant classic after its first edition in 1969.

Readers Guide to Periodical Literature

Readers  Guide to Periodical Literature Book
Author : Anna Lorraine Guthrie,Bertha Tannehill,Neltje Marie Tannehill Shimer
Publisher : Unknown
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

An author subject index to selected general interest periodicals of reference value in libraries.

Epigenetics in Cardiac Disease

Epigenetics in Cardiac Disease Book
Author : Johannes Backs,Timothy A. McKinsey
Publisher : Springer
Release : 2016-11-21
ISBN : 3319414577
Language : En, Es, Fr & De

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Book Description :

This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics.

The Human Body in Health Disease

The Human Body in Health   Disease Book
Author : Gary A. Thibodeau,Kevin T. Patton
Publisher : Mosby Incorporated
Release : 2002
ISBN : 9780323013383
Language : En, Es, Fr & De

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Book Description :

This updated third edition includes outstanding coverage of basic anatomy and physiology, plus the mechanisms of disease and pathologic conditions associated with each body system. Two unifying themes are integrated in this comprehensive text: the complementary nature of structure and function, and homeostasis. Homeostasis is used to show how normal structure and function are maintained, whereas failures of homeostasis are shown as basic mechanisms of disease. The reader is drawn into the subject by a clear, straightforward style, superior illustrations, and student-friendly features. Included FREE with the softcover text is Body Spectrum: Mosby's Electronic Anatomy Coloring Book CD-ROM. Clinical Applications (answers in back of book) at the end of each chapter are short case studies with questions that tie theory to practice A Chemistry Appendix discusses basic chemistry concepts needed for understanding basic anatomy and physiology Cadaver photos go one step beyond illustrations by providing a true visualization of the human body Detailed Outline Summaries at the end of each chapter provide the student with an excellent recap of important chapter content. Pathologic Conditionsappendix provides student with a series of tables that summarize specific pathological conditions by characteristic Medical Terminologyappendix provides a list of word parts commonly used in terms related to medicine and pathology along with tips on dissecting complex terms to determine their meanings Clinical Laboratory Values appendix provides commonly observed values for human body content and physiological conditions along with their normal ranges Boxed essays highlighting clinical examples to reinforce the concepts of how disease affects normal function and how therapies can restore normal function; health and wellness issues to reinforce the basic concepts of human structure and function by applying them in practical ways to current problems in health Study Tipswith collaborative learning activities are now listed at the end of each chapter to assist the student in how best to study the chapter materials, making this text even more student friendly than ever before. A new design and updated art program makes this edition even more attractive and motivating for the beginning anatomy and physiology student

Medical and Health Care Books and Serials in Print 1993

Medical and Health Care Books and Serials in Print  1993 Book
Author : R R Bowker Publishing
Publisher : Reed Reference Publishing
Release : 1993-03
ISBN : 9780835233378
Language : En, Es, Fr & De

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Book Description :

Download Medical and Health Care Books and Serials in Print 1993 book written by R R Bowker Publishing, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Endocrinology and Metabolism

Endocrinology and Metabolism Book
Author : Paul W. Ladenson, M.D.
Publisher : Unknown
Release : 2001
ISBN : 9780970052513
Language : En, Es, Fr & De

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Book Description :

Download Endocrinology and Metabolism book written by Paul W. Ladenson, M.D., available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Chromatin Signaling and Diseases

Chromatin Signaling and Diseases Book
Author : Olivier Binda,Martin Ernesto Fernandez-Zapico
Publisher : Academic Press
Release : 2016-08-06
ISBN : 012802609X
Language : En, Es, Fr & De

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Book Description :

Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling. After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling. Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored. Explains molecular mechanisms that regulate gene expression, which governs everything from embryonic development, growth, and human pathologies associated with aging Educates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathology Explores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signaling Helps researchers learn about the quickly expanding field of chromatin signaling

National Institutes of Health Research Grants

National Institutes of Health Research Grants Book
Author : National Institutes of Health (U.S.). Division of Research Grants
Publisher : Unknown
Release : 1983
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download National Institutes of Health Research Grants book written by National Institutes of Health (U.S.). Division of Research Grants, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Chromatin Folding in Health and Disease

Chromatin Folding in Health and Disease Book
Author : Rieke Kempfer
Publisher : Unknown
Release : 2020*
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Chromatin Folding in Health and Disease book written by Rieke Kempfer, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Human Epigenomics

Human Epigenomics Book
Author : Carsten Carlberg,Ferdinand Molnár
Publisher : Springer
Release : 2018-02-01
ISBN : 9811076146
Language : En, Es, Fr & De

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Book Description :

The term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of epigenomics, the relation of which to human health and disease is discussed in this textbook. This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin). Moreover, this book discusses the principles of gene regulation, chromatin stability, genomic imprinting and the reversibility of DNA methylation and histone modifications. This information should enable a better understanding of cell type identities and will provide new directions for studies of, for example, cellular reprograming, the response of chromatin to environmental signals and epigenetic therapies that can improve or restore human health. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule “a picture tells more than thousand words”. The content of the book is based on the lecture course “Molecular Medicine and Genetics” that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. Thematically, this book is located between our textbooks “Mechanisms of Gene Regulation” (ISBN 978-94-017-7741-4) and “Nutrigenomics” (ISBN 978-3-319-30415-1), studying of which may also be interesting to our readers. The book is sub-divided into three sections and 13 chapters. Following the Introduction (section A), section B will explain the molecular basis of epigenomics, while section C will provide examples for the impact of epigenomics in human health and disease. The lecture course is primarily designed for Master level students of biomedicine, but is also frequented by PhD students as well as by students of other bioscience disciplines. Besides its value as a textbook, Human Epigenomics will be a useful reference for individuals working in biomedicine.

Four H Veterinary Science Unit 2 Animal Disease

Four H Veterinary Science  Unit 2  Animal Disease Book
Author : Duane Rice
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Four H Veterinary Science Unit 2 Animal Disease book written by Duane Rice, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Autoantibodies and Autoimmunity

Autoantibodies and Autoimmunity Book
Author : Kenneth Michael Pollard
Publisher : Wiley-VCH Verlag GmbH
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology. The editor has assembled a team of authors to report on the latest research, technologies, and applications. Following an introductory chapter, the book goes on to cover such topics as cellular mechanisms of autoantibody production, clinical and diagnostic usefulness in human disease, and animal models used to study the elicitation of autoantibodies. The whole is rounded off with a look at future perspectives.

Research grants National Institutes of Health U S 1983 publ 1984

Research grants  National Institutes of Health  U S     1983  publ 1984 Book
Author : Anonim
Publisher : Unknown
Release : 1975*
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Research grants National Institutes of Health U S 1983 publ 1984 book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.