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Book Description :
Written by a world-class team of multidisciplinary experts, this is a reference on two highly challenging tumours occurring in the skull base and spine: chordomas and chondrosarcomas.
Book Description :
Chordomas and Chondrosarcomas of the Skull Base and Spine, Second Edition, is a major reference and guide for neurosurgeons, medical oncologists, neuroscientists, orthopedic surgeons, head and neck surgeons and radiation oncologists that treat patients and research chordomas and chondrosarcomas of the axial skeleton. This book is the unique result of the collaboration of multidisciplinary specialists from a wide variety of fields (neurological sciences, medical oncology, molecular biology, orthopedics and radiation oncology), offering the most relevant information about chordomas and chondrosarcomas of the axial skeleton from each of these fields condensed into one single volume. It contains new medical knowledge and scientific advances regarding the treatment of these types of tumors. Additionally, the book includes chapters written by the Chordoma Foundation and Sarcoma Foundation of America, providing the most valuable information and support for patients and their relatives. Presents an up-to-date, comprehensive resource that details chordomas and chondrosarcomas from a multidisciplinary approach Edited by the leading researchers in brain and skull base tumors Includes chapters written by the Chordoma Foundation and Sarcoma Foundation of America
Book Description :
A rare form of cancer, chordomas are among the most difficult tumors to treat, requiring highly specialized training and surgical expertise. Although generally slow-growing, chordomas present resection challenges due to their proximity to critical structures including the spinal cord, brainstem, nerves, and arteries. Written by an impressive cadre of internationally-renowned experts, this textbook is the most current, concise, and definitive resource on diagnosis and management of this complex pathology. Acclaimed surgeons from Brazil, Canada, Japan, Turkey, the USA, and the UK are contributors. The book starts with a historical overview, epidemiology, molecular pathogenesis, cytogenetics, local invasion and metastasis, and pathology. A thorough discussion covers diagnostic radiological and radionuclide imaging such as MRI, PET; SPECT, PET-CT, and PET-MRI, and clinical traits of skull base and spinal chordomas as defined by imaging modalities. Subsequent chapters explore decision making including selecting the most optimal techniques, surgical procedures, specialized topics, and new horizons in chordoma treatment. Key Highlights Anterior and anterolateral approaches to the clivus The use of endoscopy and intraoperative assistive technologies Midline subfrontal, middle fossa, extended petrosal, and transcondylar approaches Craniospinal fusion techniques following resection Surgery for spinal chordomas from the cervical to the sacral region Special topics such as radiation, proton beam therapy, Gamma-Knife radiosurgery, and pediatric chordomas and chondrosarcomas This is an essential text for neurosurgeons, orthopedic spine surgeons, otolaryngologists, and radiation oncologists. Read and learn from innovators who have mastered the latest state-of-the-art treatment methodologies for chordomas.
Book Description :
This book serves as a practical guide for the use of carbon ions in cancer radiotherapy. On the basis of clinical experience with more than 7,000 patients with various types of tumors treated over a period of nearly 20 years at the National Institute of Radiological Sciences, step-by-step procedures and technological development of this modality are highlighted. The book is divided into two sections, the first covering the underlying principles of physics and biology, and the second section is a systematic review by tumor site, concentrating on the role of therapeutic techniques and the pitfalls in treatment planning. Readers will learn of the superior outcomes obtained with carbon-ion therapy for various types of tumors in terms of local control and toxicities. It is essential to understand that the carbon-ion beam is like a two-edged sword: unless it is used properly, it can increase the risk of severe injury to critical organs. In early series of dose-escalation studies, some patients experienced serious adverse effects such as skin ulcers, pneumonitis, intestinal ulcers, and bone necrosis, for which salvage surgery or hospitalization was required. To preclude such detrimental results, the adequacy of therapeutic techniques and dose fractionations was carefully examined in each case. In this way, significant improvements in treatment results have been achieved and major toxicities are no longer observed. With that knowledge, experts in relevant fields expand upon techniques for treatment delivery at each anatomical site, covering indications and optimal treatment planning. With its practical focus, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists, and senior nurses whose work involves radiation therapy, as well as medical oncologists and others who are interested in radiation therapy.
Book Description :
This book contains the expert knowledge base of the field’s most experienced practitioners in the field of extradural bone and soft tissue malignancy. Chapters include modern classification, advanced anatomy, imaging, and the concepts around a multidisciplinary approach. Since treating primary tumors requires very different strategies than those used in metastatic tumors, the book devotes separate sections to each sub-discipline. For primary tumors, the text covers both benign and malignant entities and addresses unique anatomic zones such as the sacrum and skull base which require special technical expertise. For metastatic disease, the authors address the ever-important concept of prognosis, and discuss how to answer the eternal question: “How much should we do, and for whom?”. Chapters also explore the state of the art of treatment for the “big 5” histologies (renal cell, lung, breast, prostate, thyroid), with a special chapter emphasis on separation surgery and the now-standard combinatorial care between radiation and surgery. In addition, an entire section is dedicated to evolving surgical technology, which covers the use of minimally invasive techniques, navigation, robotics, 3D-printing, and other evolving technologies for spine tumor care. Infrequently-considered topics, such as how to evaluate a lesion which may be a tumor-mimic, and how to think about economic value in spine tumor surgery, are also presented. Surgical Spinal Oncology serves to help surgeons approach difficult clinical scenarios with a thoughtful, collaborative approach that leverages the best technology and thinking the field of spine oncology has to offer.
Book Description :
This book is a practical guide on image-guided robotic (CyberKnife®) radiosurgery of the brain and the spine. The volume introduces the radiosurgical community to the potential of image-guidance in the treatment of neurosurgical diseases including neuro-oncological, vascular and functional disorders. Principles of image-guided radiosurgery, including physics and radiobiology are considered. Each chapter provides a critical review of the literature and analyses of several aspects to offer an assessment of single and hypofractionated treatments. Based on the authors’ experience, tables or summaries presenting the treatment approaches and associated risks are included as well. Providing a practical guide to define the selection of dose, fractionation schemes, isodose line, margins, imaging, constraints to the structures at risk will support safe practice of neuroradiosurgery. This book aims to shed new light on the treatment of neoplastic and non-neoplastic diseases of the central nervous system using the CyberKnife® image-guided robotic radiosurgery system. It will be adopted by neurosurgery residents and neurosurgery consultants as well as residents in radiation oncology and radiation oncologists; medical physicists involved in radiosurgery procedures may also benefit from this book.
Book Description :
Since its introduction 52 years ago, Leksell radiosurgery has become a widely applied technique for the management of a diverse group of vascular, neoplastic, and functional disorders. This publication presents an update on state-of-the-art radiosurgery technology, including outcomes, by the pioneers in the field. Experts have contributed chapters on various topics. They provide a history of the development of Leksell Gamma Knife and its evolution from frame-based to the inclusion of mask-based radiosurgery in the latest Gamma Knife model. For beginners, there is valuable information related to imaging, quality assurance, patient care, anesthesia, and regulatory requirements. Advance users will appreciate the summary of the long-term outcome of important indications. Additional chapters on cavernous malformation, orbital, uveal, and ocular disorders clarify the role of radiosurgery. This book is a concise overview for physicians interested in radiosurgery. It will be of great value to neurosurgeons, radiation oncologists, and medical physicists concerned with learning about the indications of radiosurgery.
Book Description :
Chondrosarcoma, a rare cancer that develops from cartilage cells, occurs mainly in the bones but can also appear in the soft tissue of the pelvis, hip and shoulder. Unfortunately, these cancers are highly resistant to both chemotherapy and radiation, and no successful adjuvant therapies currently exist. As such, surgical treatment and resection remain the mainstays of management for patients with these tumors. This concise text is a comprehensive presentation of the current knowledge regarding the development, diagnosis and management of chondrosarcomas. Part I discusses pathology, molecular biology and imaging features of chondrosarcomas. The different types of skeletal and extraskeletal tumors are presented in detail in part II, including conventional and secondary tumors. Management approaches are outlined and described in part III - limb salvage surgery is the most common, and although less effective, radiation and chemotherapy are indicated in certain cases. Part IV examines the future of chondrosarcoma management and development of novel adjuvant therapies, as well as the relationship of this disease to similar types (e.g., chordoma). Bringing together the most up-to-date information on this rare cancer, Chondrosarcoma will be a valuable resource for orthopedic oncologists, researchers and all medical professionals treating these challenging tumors.
Book Description :
This book is a practical, up-to-date guide to the treatment of patients with brain and spinal tumors. Leading experts in the field explain treatment techniques in detail, highlighting key considerations in the use of external beam radiation therapy, intensity-modulated radiation therapy, particle therapy, radiosurgery, and stereotactic body radiation therapy. Specific recommendations are described for different tumor types, and helpful information provided on other important issues, such as the interaction of radiotherapy and systemic therapy and the avoidance of treatment complications. With the development of modern technology, highly conformal radiotherapy techniques have become more complicated, yet also more widely employed. This book will equip readers with the knowledge required to set up practices to deliver quality brain and spinal radiation therapy appropriate to each patient. It will be of benefit to radiation oncologists, clinical oncologists, medical physicists, medical dosimetrists, radiation therapists, and senior nurses as well as medical oncologists and surgical oncologists with an interest in radiotherapy.
Book Description :
The scope of this 15-20-volume set encompasses the entire field of pathology ranging from general pathological terms to specific diseases to diagnostic methods. Each volume contains homogenously structured entries and a team of international experts guarantee that the essays and definitions are scientifically sound. The A-Z format allows searching for a single word in case the reader does not know to which pathological speciality the term belongs. The major advantage of the encyclopedia is manner in which it makes relevant information available not only to pathologists, but to all clinicians and researchers of the neighbouring disciplines working with pathologists who might wish to look up terms online.
Book Description :
This book is a comprehensive guide to skull base imaging. Skull base is often a “no man’s land” that requires treatment using a team approach between neurosurgeons, head and neck surgeons, vascular interventionalists, radiotherapists, chemotherapists, and other professionals. Imaging of the skull base can be challenging because of its intricate anatomy and the broad breadth of presenting pathology. Although considerably complex, the anatomy is comparatively constant, while presenting pathologic entities may be encountered at myriad stages. Many of the pathologic processes that involve the skull base are rare, causing the average clinician to require help with their diagnosis and treatment. But, before any treatment can begin, these patients must come to imaging and receive the best test to establish the correct diagnosis and make important decisions regarding management and treatment. This book provides a guide to neuoradiologists performing that imaging and as a reference for related physicians and surgeons. The book is divided into nine sections: Pituitary Region, Cerebellopontine Angle, Anterior Cranial Fossa, Middle Cranial Fossa, Craniovertebral Junction, Posterior Cranial Fossa, Inflammatory, Sarcomas, and Anatomy. Within each section, either common findings in those skull areas or different types of sarcomas or inflammatory conditions and their imaging are detailed. The anatomy section gives examples of normal anatomy from which to compare findings against. All current imaging techniques are covered, including: CT, MRI, US, angiography, CT cisternography, nuclear medicine and plain film radiography. Each chapter additionally includes key points, classic clues, incidence, differential diagnosis, recommended treatment, and prognosis. Skull Base Imaging provides a clear and concise reference for all physicians who encounter patients with these complex and relatively rare maladies.
Book Description :
This text provides a comprehensive and contemporary overview of surgical approaches to lesions of the posterior fossa. It will serve as a resource for neurosurgeons and otologists who treat patients with tumors and vascular diseases of the posterior fossa. It provides a concise review of surgical strategies that address the most important pathologies affecting the posterior fossa. It is richly illustrated with photographs and illustrations of the surgical strategies covered. All chapters are written by experts with world-wide recognition for their contributions in their respective subspecialty. Skull Base Surgery of the Posterior Fossa will be of great utility to Neurosurgeons, Otolaryngologists, and Radiation Therapists with an interest in diseases that affect the posterior fossa, as well as Senior Residents in Neurosurgery and Otolaryngology, and Fellows of Skull Base Surgery and Otology.
Book Description :
Neurosurgery is a rapidly developing and technically demanding branch of surgery that requires a detailed knowledge of the basic neuro-sciences and a thorough clinical approach. The Oxford Textbook of Neurological Surgery is an up-to-date, objective and readable text that covers the full scope of neurosurgical practice. It is part of the Oxford Textbooks in Surgery series, edited by Professor Sir Peter Morris. The book is split into 20 overarching sections (Principles of Neurosurgery, Neuro-oncology of Intrinsic Tumours; Extra-axial Tumours and Skull Lesions; Cerebro-Pontine Angle Tumours; Sellar and Supra-Sellar Tumours; Posterior Fossa Tumours; Pineal tumours; Uncommon Tumours and Tumour Syndromes; Neurotrauma and Intensive Care; Vascular Neurosurgery; Principles of Spinal Surgery; Spinal Pathology; Spinal Trauma; Peripheral Nerve Surgery; Functional Neurosurgery; Epilepsy; Paediatric Neurosurgery; Neurosurgery for Cerebrospinal Fluid Disorders and Neurosurgical Infection). Each section takes a dual approach with, 'Generic Surgical Management' chapters that focus on specific clinical problems facing the neurosurgeon (e.g. sellar/supra-sellar tumour, Intradural Spina Tumours etc.) and 'Pathology-Specific' chapters (e.g. Glioma, Meningeal Tumours, Scoliosis and Spinal Deformity, Aneurysm etc.). Where appropriate, this division provides the reader with easily accessible information for both clinical problems which present in a regional fashion and specific pathologies. The generic chapters cover aspects such as operative approaches, neuroanatomy and nuances. Specifically each chapter in the book incorporates several strands. Firstly the fundamental neuroscience (anatomy, pathology, genetics etc.) that underlies the clinical practice. Secondly, a review of the requisite clinical investigations (e.g. angiography, electrodiagnostics, radiology). Thirdly, a thorough evidence based review of clinical practice. Following this a consideration of the key debates and controversies in the field with 'pro-' and 'con-' sections (e.g. minimally invasive spine surgery, microsurgical treatment of aneurysms) is provided. A summary of the key papers and clinical scales relevant to neurosurgery form the concluding part. The book is a 'one-stop' text for trainees and consultants in neurosurgery, residents, those preparing for sub-specialty exams and other professionals allied to surgery who need to gain an understanding of the field. It acts as both a point of reference to provide a focussed refresher for the experienced neurosurgeon as well as a trusted training resource.
Book Description :
Download Clinical Radiation Pathology book written by Philip Rubin,George W. Casarett, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.
Book Description :
Purpose: to evaluate the short-term outcomes in terms of tumor control and toxicity of patients with skull base or cervical spine chordoma and chondrosarcoma treated with intensity-modulated proton or carbon-ion radiation therapy. Methods: Between 6/2014 and 7/2018, a total of 91 patients were treated with proton and/or carbon ion radiotherapy at the Shanghai Proton and Heavy Ion Center. The median age was 38 (range, 4-70) years. Forty-six (50.5%) patients were treated definitively for their conditions as initial diagnosis, 45 (49.5%) patients had recurrent tumors including 14 had prior radiotherapy. The median gross tumor volume was 37.0 (range, 1.6-231.7) cc. Eight patients received proton therapy alone, 28 patients received combined proton and carbon ion therapy, 55 patients received carbon-ion therapy alone. Results: With a median follow-up time of 28 (range, 8-59) months, the 2-year local control (LC), progression free (PFS) and overall survival (OS) rates was 86.2%, 76.8%, and 87.2%, respectively. Those rates for patients received definitive proton or carbon-ion therapy were 86.7%, 82.8%, and 93.8%, respectively. On multivariate analyses, tumor volume of > 60cc was the only significant factor for predicting PFS (p=0.045), while re-irradiation (p=0.012) and tumor volume (> vs
Book Description :
This book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.
Book Description :
Intensity-modulated radiation therapy (IMRT), one of the most important developments in radiation oncology in the past 25 years, involves technology to deliver radiation to tumors in the right location, quantity and time. Unavoidable irradiation of surrounding normal tissues is distributed so as to preserve their function. The achievements and future directions in the field are grouped in the three sections of the book, each suitable for supporting a teaching course. Part 1 contains topical reviews of the basic principles of IMRT, part 2 describes advanced techniques such as image-guided and biologically based approaches, and part 3 focuses on investigation of IMRT to improve outcome at various cancer sites.
Book Description :
"The combined endoscopic endonasal, transethmoidal, transcribriform approach with endoscope-assisted supraorbital craniotomy is a minimally invasive approach that can be used as an alternative to the classic transcranial, transfacial, or combined craniofacial approaches to lesions of the anterior cranial fossa. This approach is best used for lesions that extend anteriorly to the frontal sinus, laterally beyond the lamina papyracea, and inferiorly into the ethmoid sinus. This chapter details the approach as well as closure of the combined endoscopic endonasal, transethmoidal, transcribriform approach with endoscope-assisted supraorbital craniotomy"--
Book Description :
Fully updated new edition covering all aspects of bone and joint diseases in one easily readable volume. Color illustrations throughout.
Book Description :
This edition of ICD-O, the standard tool for coding diagnoses of neoplasms in tumour and cancer registrars and in pathology laboratories, has been developed by a working party convened by the International Agency for Research on Cancer / WHO. ICD-O is a dual classification with coding systems for both topography and morphology. The book has five main sections. The first provides general instructions for using the coding systems and gives rules for their implementation in tumour registries and pathology laboratories. Section two includes the numerical list of topography codes, which remain unchanged from the previous edition. The numerical list of morphology codes is presented in the next section, which introduces several new terms and includes considerable revisions of the non-Hodgkin lymphoma and leukaemia sections, based on the WHO Classification of Hematopoietic and Lympoid Diseases. The five-digit morphology codes allow identification of a tumour or cell type by histology, behaviour, and grade. Revisions in the morphology section were made in consultation with a large number of experts and were finalised after field-testing in cancer registries around the world. The alphabetical index gives codes for both topography and morphology and includes selected tumour-like lesions and conditions. A guide to differences in morphology codes between the second and third editions is provided in the final section, which includes lists of all new code numbers, new terms and synonyms added to existing code definitions, terms that changed morphology code, terms for conditions now considered malignant, deleted terms, and terms that changed behaviour code.